%PDF-1.3 1 0 obj << /Type /Catalog /Outlines 2 0 R /Pages 3 0 R >> endobj 2 0 obj << /Type /Outlines /Count 0 >> endobj 3 0 obj << /Type /Pages /Kids [6 0 R 188 0 R 233 0 R 295 0 R 316 0 R 332 0 R 395 0 R 529 0 R 531 0 R 533 0 R ] /Count 10 /Resources << /ProcSet 4 0 R /Font << /F1 8 0 R /F2 9 0 R /F3 10 0 R /F4 11 0 R >> /XObject << /I1 12 0 R /I2 13 0 R /I3 204 0 R /I4 303 0 R /I5 320 0 R /I6 323 0 R /I7 336 0 R >> >> /MediaBox [0.000 0.000 612.000 792.000] >> endobj 4 0 obj [/PDF /Text /ImageC ] endobj 5 0 obj << /Creator (DOMPDF) /CreationDate (D:20180723022202+00'00') /ModDate (D:20180723022202+00'00') /Title (Social Cognition, Executive Functions and Self-Report of Psychological Distress in Huntingtons Disease PLOS Currents Huntington Disease) >> endobj 6 0 obj << /Type /Page /Parent 3 0 R /Annots [ 14 0 R 16 0 R 18 0 R 20 0 R 22 0 R 24 0 R 26 0 R 28 0 R 30 0 R 32 0 R 34 0 R 36 0 R 38 0 R 40 0 R 42 0 R 44 0 R 46 0 R 48 0 R 50 0 R 52 0 R 54 0 R 56 0 R 58 0 R 60 0 R 62 0 R 64 0 R 66 0 R 68 0 R 70 0 R 72 0 R 74 0 R 76 0 R 78 0 R 80 0 R 82 0 R 84 0 R 86 0 R 88 0 R 90 0 R 92 0 R 94 0 R 96 0 R 98 0 R 100 0 R 102 0 R 104 0 R 106 0 R 108 0 R 110 0 R 112 0 R 114 0 R 116 0 R 118 0 R 120 0 R 122 0 R 124 0 R 126 0 R 128 0 R 130 0 R 132 0 R 134 0 R 136 0 R 138 0 R 140 0 R 142 0 R 144 0 R 146 0 R 148 0 R 150 0 R 152 0 R 154 0 R 156 0 R 158 0 R 160 0 R 162 0 R 164 0 R 166 0 R 168 0 R 170 0 R 172 0 R 174 0 R 176 0 R 178 0 R 180 0 R 182 0 R 184 0 R 186 0 R ] /Contents 7 0 R >> endobj 7 0 obj << /Length 30488 >> stream q 375.000 0 0 39.000 222.000 738.000 cm /I2 Do Q q 15.000 684.354 577.500 53.646 re W n 0.267 0.267 0.267 rg BT 15.000 718.042 Td /F2 21.0 Tf [(Social Cognition, Executive Functions and Self-Report of )] TJ ET BT 15.000 693.094 Td /F2 21.0 Tf [(Psychological Distress in Huntingtons Disease)] TJ ET Q 0.271 0.267 0.267 rg BT 15.000 675.088 Td /F3 9.8 Tf [(December 28, 2016)] TJ ET BT 96.500 675.088 Td /F3 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg BT 101.375 675.088 Td /F3 9.8 Tf [(Research Article)] TJ ET BT 26.250 663.247 Td /F1 9.8 Tf [(Ida Unmack Larsen)] TJ ET 0.271 0.267 0.267 rg BT 110.782 663.247 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 116.204 663.247 Td /F1 9.8 Tf [(Tua Vinther-Jensen)] TJ ET 0.271 0.267 0.267 rg BT 201.282 663.247 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 206.703 663.247 Td /F1 9.8 Tf [(Jrgen Erik Nielsen)] TJ ET 0.271 0.267 0.267 rg BT 291.762 663.247 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 297.183 663.247 Td /F1 9.8 Tf [(Anders Gade)] TJ ET 0.271 0.267 0.267 rg BT 354.630 663.247 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 360.051 663.247 Td /F1 9.8 Tf [(Asmus Vogel)] TJ ET 0.271 0.267 0.267 rg BT 26.250 651.342 Td /F1 9.8 Tf [(Larsen IU, Vinther-Jensen T, Nielsen JE, Gade A, Vogel A. Social Cognition, Executive Functions and Self-Report of )] TJ ET BT 26.250 639.438 Td /F1 9.8 Tf [(Psychological Distress in Huntingtons Disease. PLOS Currents Huntington Disease. 2016 Dec 28 . Edition 1. doi: )] TJ ET BT 26.250 627.533 Td /F1 9.8 Tf [(10.1371/currents.hd.bba3a680813122013e6d3e8a144c1da8.)] TJ ET q 15.000 28.220 577.500 596.932 re W n 0.271 0.267 0.267 rg BT 26.250 598.430 Td /F4 12.0 Tf [(Abstract)] TJ ET BT 26.250 578.476 Td /F1 9.8 Tf [(Objective: Huntingtons disease \(HD\) is characterized by motor symptoms, psychiatric symptoms and cognitive impairment in, )] TJ ET BT 26.250 566.571 Td /F1 9.8 Tf [(inter alia, executive functions and social cognition. The aim of this study was to investigate the relationship between subjective )] TJ ET BT 26.250 554.667 Td /F1 9.8 Tf [(feeling of psychological distress using a self-report questionnaire and performances on tests of executive functions and social )] TJ ET BT 26.250 542.762 Td /F1 9.8 Tf [(cognition in a large consecutive cohort of HD patients.)] TJ ET BT 26.250 523.357 Td /F1 9.8 Tf [(Method: 50 manifest HD patients were tested in social cognition and executive functions and each answered a self-report )] TJ ET BT 26.250 511.452 Td /F1 9.8 Tf [(questionnaire about current status of perceived psychological distress \(the Symptom Checklist-90-Revised \(SCL-90-R\)\). )] TJ ET BT 26.250 499.548 Td /F1 9.8 Tf [(Correlation analyses of test performance and SCL-90-R scores were made as well as stepwise linear regression analyses with )] TJ ET BT 26.250 487.643 Td /F1 9.8 Tf [(the SCL-90-R GSI score and test performances as dependent variables.)] TJ ET BT 26.250 468.238 Td /F1 9.8 Tf [(Results: We found that less psychological distress was significantly associated with worse performances on social cognitive )] TJ ET BT 26.250 456.333 Td /F1 9.8 Tf [(tests \(mean absolute correlation .34\) and that there were no significant correlations between perceived psychological distress )] TJ ET BT 26.250 444.429 Td /F1 9.8 Tf [(and performance on tests of executive functions. The correlations between perceived psychological distress and performance )] TJ ET BT 26.250 432.524 Td /F1 9.8 Tf [(on social cognitive tests remained significant after controlling for age, Unified Huntingtons Disease Rating Scale-99 total motor )] TJ ET BT 26.250 420.619 Td /F1 9.8 Tf [(score and performance on tests of executive functions.)] TJ ET BT 26.250 401.214 Td /F1 9.8 Tf [(Conclusions: Based on previous findings that insight and apathy are closely connected and may be mediated by overlapping )] TJ ET BT 26.250 389.310 Td /F1 9.8 Tf [(neuroanatomical networks involving the prefrontal cortex and frontostriatal circuits, we speculate that apathy/and or impaired )] TJ ET BT 26.250 377.405 Td /F1 9.8 Tf [(insight may offer an explanation for the correlation between self-report of psychological distress and performance on social )] TJ ET BT 26.250 365.500 Td /F1 9.8 Tf [(cognitive tests in this study.)] TJ ET BT 26.250 328.898 Td /F4 12.0 Tf [(Funding Statement)] TJ ET BT 26.250 308.943 Td /F1 9.8 Tf [(Ida Unmack Larsen and Tua Vinther-Jensen are both supported by grants from Copenhagen University. Jrgen Erik Nielsen is )] TJ ET BT 26.250 297.039 Td /F1 9.8 Tf [(supported by a research grant from the Novo Nordisk Foundation. The funders had no role in study design, data collection and )] TJ ET BT 26.250 285.134 Td /F1 9.8 Tf [(analysis, decision to publish, or preparation of the manuscript.)] TJ ET BT 26.250 256.031 Td /F4 12.0 Tf [(Introduction)] TJ ET BT 26.250 236.077 Td /F1 9.8 Tf [(Huntingtons disease \(HD\) is an autosomal dominantly inherited neurodegenerative disorder caused by an expanded CAG )] TJ ET BT 26.250 224.172 Td /F1 9.8 Tf [(repeat on chromosome 4)] TJ ET 0.267 0.267 0.267 rg BT 134.631 225.680 Td /F4 8.7 Tf [(1)] TJ ET 0.271 0.267 0.267 rg BT 139.450 224.172 Td /F1 9.8 Tf [( and characterized by motor symptoms, psychiatric symptoms and cognitive decline. Once onset of )] TJ ET BT 26.250 212.268 Td /F1 9.8 Tf [(motor symptoms has occurred, cognitive and/or psychiatric symptoms also tend to be present )] TJ ET 0.267 0.267 0.267 rg BT 432.113 213.775 Td /F4 8.7 Tf [(2)] TJ ET 0.271 0.267 0.267 rg BT 436.932 216.156 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 439.341 213.775 Td /F4 8.7 Tf [(3)] TJ ET 0.271 0.267 0.267 rg BT 444.160 216.156 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 446.569 213.775 Td /F4 8.7 Tf [(4)] TJ ET 0.271 0.267 0.267 rg BT 451.388 216.156 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 453.797 213.775 Td /F4 8.7 Tf [(5)] TJ ET 0.271 0.267 0.267 rg BT 458.616 212.268 Td /F1 9.8 Tf [(. The cognitive )] TJ ET BT 26.250 200.363 Td /F1 9.8 Tf [(deterioration in HD is thought to be related to dysfunction of the frontostriatal circuits due to gradual degeneration of the striatum)] TJ ET 0.267 0.267 0.267 rg BT 26.250 189.965 Td /F4 8.7 Tf [(6)] TJ ET 0.271 0.267 0.267 rg BT 31.069 192.346 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 33.478 189.965 Td /F4 8.7 Tf [(7)] TJ ET 0.271 0.267 0.267 rg BT 38.297 188.458 Td /F1 9.8 Tf [(. Accordingly, the first signs of cognitive impairment are observed in cognitive functions associated with the prefrontal cortex )] TJ ET BT 26.250 176.553 Td /F1 9.8 Tf [(such as executive functions and social cognitive functions)] TJ ET 0.267 0.267 0.267 rg BT 274.992 178.061 Td /F4 8.7 Tf [(4)] TJ ET 0.271 0.267 0.267 rg BT 279.811 180.442 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 282.220 178.061 Td /F4 8.7 Tf [(8)] TJ ET 0.271 0.267 0.267 rg BT 287.039 180.442 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 289.448 178.061 Td /F4 8.7 Tf [(9)] TJ ET 0.271 0.267 0.267 rg BT 294.267 180.442 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 296.676 178.061 Td /F4 8.7 Tf [(10)] TJ ET 0.271 0.267 0.267 rg BT 306.313 176.553 Td /F1 9.8 Tf [(. Psychiatric symptoms are also commonly found even in the )] TJ ET BT 26.250 164.649 Td /F1 9.8 Tf [(presymptomatic and earliest stages in HD, and a wide variety of psychiatric symptoms such as apathy, depression, irritability, )] TJ ET BT 26.250 152.744 Td /F1 9.8 Tf [(anxiety, mania and obsessive compulsive symptoms can be seen)] TJ ET 0.267 0.267 0.267 rg BT 308.571 154.251 Td /F4 8.7 Tf [(11)] TJ ET 0.271 0.267 0.267 rg BT 318.208 152.744 Td /F1 9.8 Tf [(.)] TJ ET BT 26.250 133.339 Td /F1 9.8 Tf [(Performance on tests of social cognition and executive functions are often affected by psychopathology. Associations between )] TJ ET BT 26.250 121.434 Td /F1 9.8 Tf [(social cognitive functions, executive functions and psychiatric symptoms have been investigated in both psychiatric and )] TJ ET BT 26.250 109.530 Td /F1 9.8 Tf [(neurological disorders such as schizophrenia, depression, bipolar disorder, Parkinsons disease \(PD\) and frontotemporal )] TJ ET BT 26.250 97.625 Td /F1 9.8 Tf [(dementia \(FTD\))] TJ ET 0.267 0.267 0.267 rg BT 94.510 99.132 Td /F4 8.7 Tf [(12)] TJ ET 0.271 0.267 0.267 rg BT 104.147 101.513 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 106.556 99.132 Td /F4 8.7 Tf [(13)] TJ ET 0.271 0.267 0.267 rg BT 116.194 101.513 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 118.603 99.132 Td /F4 8.7 Tf [(14)] TJ ET 0.271 0.267 0.267 rg BT 128.240 101.513 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 130.650 99.132 Td /F4 8.7 Tf [(15)] TJ ET 0.271 0.267 0.267 rg BT 140.287 101.513 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 142.696 99.132 Td /F4 8.7 Tf [(16)] TJ ET 0.271 0.267 0.267 rg BT 152.334 101.513 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 154.743 99.132 Td /F4 8.7 Tf [(17)] TJ ET 0.271 0.267 0.267 rg BT 164.380 101.513 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 166.790 99.132 Td /F4 8.7 Tf [(18)] TJ ET 0.271 0.267 0.267 rg BT 176.427 97.625 Td /F1 9.8 Tf [(. The most common finding being that greater degree of psychiatric symptoms are )] TJ ET BT 26.250 85.720 Td /F1 9.8 Tf [(associated to worse performance on tests of executive functions and social cognition.)] TJ ET BT 26.250 66.315 Td /F1 9.8 Tf [(In two previous studies we have investigated performance on tests of executive functions and social cognition in a large cohort )] TJ ET BT 26.250 54.411 Td /F1 9.8 Tf [(of HD patients in early-moderate disease stage and found a high frequency of impaired performances on tests of executive )] TJ ET BT 26.250 42.506 Td /F1 9.8 Tf [(functions and social cognition)] TJ ET 0.267 0.267 0.267 rg BT 153.605 44.013 Td /F4 8.7 Tf [(2)] TJ ET 0.271 0.267 0.267 rg BT 158.423 46.394 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 160.833 44.013 Td /F4 8.7 Tf [(4)] TJ ET 0.271 0.267 0.267 rg BT 165.651 42.506 Td /F1 9.8 Tf [(. Based on the associations between the presence of psychiatric symptoms and impairments in )] TJ ET Q q 15.000 684.354 577.500 53.646 re W n 0.267 0.267 0.267 rg BT 15.000 718.042 Td /F2 21.0 Tf [(Social Cognition, Executive Functions and Self-Report of )] TJ ET BT 15.000 693.094 Td /F2 21.0 Tf [(Psychological Distress in Huntingtons Disease)] TJ ET Q 0.271 0.267 0.267 rg BT 15.000 675.088 Td /F3 9.8 Tf [(December 28, 2016)] TJ ET BT 96.500 675.088 Td /F3 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg BT 101.375 675.088 Td /F3 9.8 Tf [(Research Article)] TJ ET BT 26.250 663.247 Td /F1 9.8 Tf [(Ida Unmack Larsen)] TJ ET 0.271 0.267 0.267 rg BT 110.782 663.247 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 116.204 663.247 Td /F1 9.8 Tf [(Tua Vinther-Jensen)] TJ ET 0.271 0.267 0.267 rg BT 201.282 663.247 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 206.703 663.247 Td /F1 9.8 Tf [(Jrgen Erik Nielsen)] TJ ET 0.271 0.267 0.267 rg BT 291.762 663.247 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 297.183 663.247 Td /F1 9.8 Tf [(Anders Gade)] TJ ET 0.271 0.267 0.267 rg BT 354.630 663.247 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 360.051 663.247 Td /F1 9.8 Tf [(Asmus Vogel)] TJ ET 0.271 0.267 0.267 rg BT 26.250 651.342 Td /F1 9.8 Tf [(Larsen IU, Vinther-Jensen T, Nielsen JE, Gade A, Vogel A. Social Cognition, Executive Functions and Self-Report of )] TJ ET BT 26.250 639.438 Td /F1 9.8 Tf [(Psychological Distress in Huntingtons Disease. PLOS Currents Huntington Disease. 2016 Dec 28 . Edition 1. doi: )] TJ ET BT 26.250 627.533 Td /F1 9.8 Tf [(10.1371/currents.hd.bba3a680813122013e6d3e8a144c1da8.)] TJ ET q 15.000 28.220 577.500 596.932 re W n 0.271 0.267 0.267 rg BT 26.250 598.430 Td /F4 12.0 Tf [(Abstract)] TJ ET BT 26.250 578.476 Td /F1 9.8 Tf [(Objective: Huntingtons disease \(HD\) is characterized by motor symptoms, psychiatric symptoms and cognitive impairment in, )] TJ ET BT 26.250 566.571 Td /F1 9.8 Tf [(inter alia, executive functions and social cognition. The aim of this study was to investigate the relationship between subjective )] TJ ET BT 26.250 554.667 Td /F1 9.8 Tf [(feeling of psychological distress using a self-report questionnaire and performances on tests of executive functions and social )] TJ ET BT 26.250 542.762 Td /F1 9.8 Tf [(cognition in a large consecutive cohort of HD patients.)] TJ ET BT 26.250 523.357 Td /F1 9.8 Tf [(Method: 50 manifest HD patients were tested in social cognition and executive functions and each answered a self-report )] TJ ET BT 26.250 511.452 Td /F1 9.8 Tf [(questionnaire about current status of perceived psychological distress \(the Symptom Checklist-90-Revised \(SCL-90-R\)\). )] TJ ET BT 26.250 499.548 Td /F1 9.8 Tf [(Correlation analyses of test performance and SCL-90-R scores were made as well as stepwise linear regression analyses with )] TJ ET BT 26.250 487.643 Td /F1 9.8 Tf [(the SCL-90-R GSI score and test performances as dependent variables.)] TJ ET BT 26.250 468.238 Td /F1 9.8 Tf [(Results: We found that less psychological distress was significantly associated with worse performances on social cognitive )] TJ ET BT 26.250 456.333 Td /F1 9.8 Tf [(tests \(mean absolute correlation .34\) and that there were no significant correlations between perceived psychological distress )] TJ ET BT 26.250 444.429 Td /F1 9.8 Tf [(and performance on tests of executive functions. The correlations between perceived psychological distress and performance )] TJ ET BT 26.250 432.524 Td /F1 9.8 Tf [(on social cognitive tests remained significant after controlling for age, Unified Huntingtons Disease Rating Scale-99 total motor )] TJ ET BT 26.250 420.619 Td /F1 9.8 Tf [(score and performance on tests of executive functions.)] TJ ET BT 26.250 401.214 Td /F1 9.8 Tf [(Conclusions: Based on previous findings that insight and apathy are closely connected and may be mediated by overlapping )] TJ ET BT 26.250 389.310 Td /F1 9.8 Tf [(neuroanatomical networks involving the prefrontal cortex and frontostriatal circuits, we speculate that apathy/and or impaired )] TJ ET BT 26.250 377.405 Td /F1 9.8 Tf [(insight may offer an explanation for the correlation between self-report of psychological distress and performance on social )] TJ ET BT 26.250 365.500 Td /F1 9.8 Tf [(cognitive tests in this study.)] TJ ET BT 26.250 328.898 Td /F4 12.0 Tf [(Funding Statement)] TJ ET BT 26.250 308.943 Td /F1 9.8 Tf [(Ida Unmack Larsen and Tua Vinther-Jensen are both supported by grants from Copenhagen University. Jrgen Erik Nielsen is )] TJ ET BT 26.250 297.039 Td /F1 9.8 Tf [(supported by a research grant from the Novo Nordisk Foundation. The funders had no role in study design, data collection and )] TJ ET BT 26.250 285.134 Td /F1 9.8 Tf [(analysis, decision to publish, or preparation of the manuscript.)] TJ ET BT 26.250 256.031 Td /F4 12.0 Tf [(Introduction)] TJ ET BT 26.250 236.077 Td /F1 9.8 Tf [(Huntingtons disease \(HD\) is an autosomal dominantly inherited neurodegenerative disorder caused by an expanded CAG )] TJ ET BT 26.250 224.172 Td /F1 9.8 Tf [(repeat on chromosome 4)] TJ ET 0.267 0.267 0.267 rg BT 134.631 225.680 Td /F4 8.7 Tf [(1)] TJ ET 0.271 0.267 0.267 rg BT 139.450 224.172 Td /F1 9.8 Tf [( and characterized by motor symptoms, psychiatric symptoms and cognitive decline. Once onset of )] TJ ET BT 26.250 212.268 Td /F1 9.8 Tf [(motor symptoms has occurred, cognitive and/or psychiatric symptoms also tend to be present )] TJ ET 0.267 0.267 0.267 rg BT 432.113 213.775 Td /F4 8.7 Tf [(2)] TJ ET 0.271 0.267 0.267 rg BT 436.932 216.156 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 439.341 213.775 Td /F4 8.7 Tf [(3)] TJ ET 0.271 0.267 0.267 rg BT 444.160 216.156 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 446.569 213.775 Td /F4 8.7 Tf [(4)] TJ ET 0.271 0.267 0.267 rg BT 451.388 216.156 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 453.797 213.775 Td /F4 8.7 Tf [(5)] TJ ET 0.271 0.267 0.267 rg BT 458.616 212.268 Td /F1 9.8 Tf [(. The cognitive )] TJ ET BT 26.250 200.363 Td /F1 9.8 Tf [(deterioration in HD is thought to be related to dysfunction of the frontostriatal circuits due to gradual degeneration of the striatum)] TJ ET 0.267 0.267 0.267 rg BT 26.250 189.965 Td /F4 8.7 Tf [(6)] TJ ET 0.271 0.267 0.267 rg BT 31.069 192.346 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 33.478 189.965 Td /F4 8.7 Tf [(7)] TJ ET 0.271 0.267 0.267 rg BT 38.297 188.458 Td /F1 9.8 Tf [(. Accordingly, the first signs of cognitive impairment are observed in cognitive functions associated with the prefrontal cortex )] TJ ET BT 26.250 176.553 Td /F1 9.8 Tf [(such as executive functions and social cognitive functions)] TJ ET 0.267 0.267 0.267 rg BT 274.992 178.061 Td /F4 8.7 Tf [(4)] TJ ET 0.271 0.267 0.267 rg BT 279.811 180.442 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 282.220 178.061 Td /F4 8.7 Tf [(8)] TJ ET 0.271 0.267 0.267 rg BT 287.039 180.442 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 289.448 178.061 Td /F4 8.7 Tf [(9)] TJ ET 0.271 0.267 0.267 rg BT 294.267 180.442 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 296.676 178.061 Td /F4 8.7 Tf [(10)] TJ ET 0.271 0.267 0.267 rg BT 306.313 176.553 Td /F1 9.8 Tf [(. Psychiatric symptoms are also commonly found even in the )] TJ ET BT 26.250 164.649 Td /F1 9.8 Tf [(presymptomatic and earliest stages in HD, and a wide variety of psychiatric symptoms such as apathy, depression, irritability, )] TJ ET BT 26.250 152.744 Td /F1 9.8 Tf [(anxiety, mania and obsessive compulsive symptoms can be seen)] TJ ET 0.267 0.267 0.267 rg BT 308.571 154.251 Td /F4 8.7 Tf [(11)] TJ ET 0.271 0.267 0.267 rg BT 318.208 152.744 Td /F1 9.8 Tf [(.)] TJ ET BT 26.250 133.339 Td /F1 9.8 Tf [(Performance on tests of social cognition and executive functions are often affected by psychopathology. Associations between )] TJ ET BT 26.250 121.434 Td /F1 9.8 Tf [(social cognitive functions, executive functions and psychiatric symptoms have been investigated in both psychiatric and )] TJ ET BT 26.250 109.530 Td /F1 9.8 Tf [(neurological disorders such as schizophrenia, depression, bipolar disorder, Parkinsons disease \(PD\) and frontotemporal )] TJ ET BT 26.250 97.625 Td /F1 9.8 Tf [(dementia \(FTD\))] TJ ET 0.267 0.267 0.267 rg BT 94.510 99.132 Td /F4 8.7 Tf [(12)] TJ ET 0.271 0.267 0.267 rg BT 104.147 101.513 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 106.556 99.132 Td /F4 8.7 Tf [(13)] TJ ET 0.271 0.267 0.267 rg BT 116.194 101.513 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 118.603 99.132 Td /F4 8.7 Tf [(14)] TJ ET 0.271 0.267 0.267 rg BT 128.240 101.513 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 130.650 99.132 Td /F4 8.7 Tf [(15)] TJ ET 0.271 0.267 0.267 rg BT 140.287 101.513 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 142.696 99.132 Td /F4 8.7 Tf [(16)] TJ ET 0.271 0.267 0.267 rg BT 152.334 101.513 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 154.743 99.132 Td /F4 8.7 Tf [(17)] TJ ET 0.271 0.267 0.267 rg BT 164.380 101.513 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 166.790 99.132 Td /F4 8.7 Tf [(18)] TJ ET 0.271 0.267 0.267 rg BT 176.427 97.625 Td /F1 9.8 Tf [(. The most common finding being that greater degree of psychiatric symptoms are )] TJ ET BT 26.250 85.720 Td /F1 9.8 Tf [(associated to worse performance on tests of executive functions and social cognition.)] TJ ET BT 26.250 66.315 Td /F1 9.8 Tf [(In two previous studies we have investigated performance on tests of executive functions and social cognition in a large cohort )] TJ ET BT 26.250 54.411 Td /F1 9.8 Tf [(of HD patients in early-moderate disease stage and found a high frequency of impaired performances on tests of executive )] TJ ET BT 26.250 42.506 Td /F1 9.8 Tf [(functions and social cognition)] TJ ET 0.267 0.267 0.267 rg BT 153.605 44.013 Td /F4 8.7 Tf [(2)] TJ ET 0.271 0.267 0.267 rg BT 158.423 46.394 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 160.833 44.013 Td /F4 8.7 Tf [(4)] TJ ET 0.271 0.267 0.267 rg BT 165.651 42.506 Td /F1 9.8 Tf [(. Based on the associations between the presence of psychiatric symptoms and impairments in )] TJ ET Q q 15.000 684.354 577.500 53.646 re W n 0.267 0.267 0.267 rg BT 15.000 718.042 Td /F2 21.0 Tf [(Social Cognition, Executive Functions and Self-Report of )] TJ ET BT 15.000 693.094 Td /F2 21.0 Tf [(Psychological Distress in Huntingtons Disease)] TJ ET Q 0.271 0.267 0.267 rg BT 15.000 675.088 Td /F3 9.8 Tf [(December 28, 2016)] TJ ET BT 96.500 675.088 Td /F3 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg BT 101.375 675.088 Td /F3 9.8 Tf [(Research Article)] TJ ET BT 26.250 663.247 Td /F1 9.8 Tf [(Ida Unmack Larsen)] TJ ET 0.271 0.267 0.267 rg BT 110.782 663.247 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 116.204 663.247 Td /F1 9.8 Tf [(Tua Vinther-Jensen)] TJ ET 0.271 0.267 0.267 rg BT 201.282 663.247 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 206.703 663.247 Td /F1 9.8 Tf [(Jrgen Erik Nielsen)] TJ ET 0.271 0.267 0.267 rg BT 291.762 663.247 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 297.183 663.247 Td /F1 9.8 Tf [(Anders Gade)] TJ ET 0.271 0.267 0.267 rg BT 354.630 663.247 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 360.051 663.247 Td /F1 9.8 Tf [(Asmus Vogel)] TJ ET 0.271 0.267 0.267 rg BT 26.250 651.342 Td /F1 9.8 Tf [(Larsen IU, Vinther-Jensen T, Nielsen JE, Gade A, Vogel A. Social Cognition, Executive Functions and Self-Report of )] TJ ET BT 26.250 639.438 Td /F1 9.8 Tf [(Psychological Distress in Huntingtons Disease. PLOS Currents Huntington Disease. 2016 Dec 28 . Edition 1. doi: )] TJ ET BT 26.250 627.533 Td /F1 9.8 Tf [(10.1371/currents.hd.bba3a680813122013e6d3e8a144c1da8.)] TJ ET q 15.000 28.220 577.500 596.932 re W n 0.271 0.267 0.267 rg BT 26.250 598.430 Td /F4 12.0 Tf [(Abstract)] TJ ET BT 26.250 578.476 Td /F1 9.8 Tf [(Objective: Huntingtons disease \(HD\) is characterized by motor symptoms, psychiatric symptoms and cognitive impairment in, )] TJ ET BT 26.250 566.571 Td /F1 9.8 Tf [(inter alia, executive functions and social cognition. The aim of this study was to investigate the relationship between subjective )] TJ ET BT 26.250 554.667 Td /F1 9.8 Tf [(feeling of psychological distress using a self-report questionnaire and performances on tests of executive functions and social )] TJ ET BT 26.250 542.762 Td /F1 9.8 Tf [(cognition in a large consecutive cohort of HD patients.)] TJ ET BT 26.250 523.357 Td /F1 9.8 Tf [(Method: 50 manifest HD patients were tested in social cognition and executive functions and each answered a self-report )] TJ ET BT 26.250 511.452 Td /F1 9.8 Tf [(questionnaire about current status of perceived psychological distress \(the Symptom Checklist-90-Revised \(SCL-90-R\)\). )] TJ ET BT 26.250 499.548 Td /F1 9.8 Tf [(Correlation analyses of test performance and SCL-90-R scores were made as well as stepwise linear regression analyses with )] TJ ET BT 26.250 487.643 Td /F1 9.8 Tf [(the SCL-90-R GSI score and test performances as dependent variables.)] TJ ET BT 26.250 468.238 Td /F1 9.8 Tf [(Results: We found that less psychological distress was significantly associated with worse performances on social cognitive )] TJ ET BT 26.250 456.333 Td /F1 9.8 Tf [(tests \(mean absolute correlation .34\) and that there were no significant correlations between perceived psychological distress )] TJ ET BT 26.250 444.429 Td /F1 9.8 Tf [(and performance on tests of executive functions. The correlations between perceived psychological distress and performance )] TJ ET BT 26.250 432.524 Td /F1 9.8 Tf [(on social cognitive tests remained significant after controlling for age, Unified Huntingtons Disease Rating Scale-99 total motor )] TJ ET BT 26.250 420.619 Td /F1 9.8 Tf [(score and performance on tests of executive functions.)] TJ ET BT 26.250 401.214 Td /F1 9.8 Tf [(Conclusions: Based on previous findings that insight and apathy are closely connected and may be mediated by overlapping )] TJ ET BT 26.250 389.310 Td /F1 9.8 Tf [(neuroanatomical networks involving the prefrontal cortex and frontostriatal circuits, we speculate that apathy/and or impaired )] TJ ET BT 26.250 377.405 Td /F1 9.8 Tf [(insight may offer an explanation for the correlation between self-report of psychological distress and performance on social )] TJ ET BT 26.250 365.500 Td /F1 9.8 Tf [(cognitive tests in this study.)] TJ ET BT 26.250 328.898 Td /F4 12.0 Tf [(Funding Statement)] TJ ET BT 26.250 308.943 Td /F1 9.8 Tf [(Ida Unmack Larsen and Tua Vinther-Jensen are both supported by grants from Copenhagen University. Jrgen Erik Nielsen is )] TJ ET BT 26.250 297.039 Td /F1 9.8 Tf [(supported by a research grant from the Novo Nordisk Foundation. The funders had no role in study design, data collection and )] TJ ET BT 26.250 285.134 Td /F1 9.8 Tf [(analysis, decision to publish, or preparation of the manuscript.)] TJ ET BT 26.250 256.031 Td /F4 12.0 Tf [(Introduction)] TJ ET BT 26.250 236.077 Td /F1 9.8 Tf [(Huntingtons disease \(HD\) is an autosomal dominantly inherited neurodegenerative disorder caused by an expanded CAG )] TJ ET BT 26.250 224.172 Td /F1 9.8 Tf [(repeat on chromosome 4)] TJ ET 0.267 0.267 0.267 rg BT 134.631 225.680 Td /F4 8.7 Tf [(1)] TJ ET 0.271 0.267 0.267 rg BT 139.450 224.172 Td /F1 9.8 Tf [( and characterized by motor symptoms, psychiatric symptoms and cognitive decline. Once onset of )] TJ ET BT 26.250 212.268 Td /F1 9.8 Tf [(motor symptoms has occurred, cognitive and/or psychiatric symptoms also tend to be present )] TJ ET 0.267 0.267 0.267 rg BT 432.113 213.775 Td /F4 8.7 Tf [(2)] TJ ET 0.271 0.267 0.267 rg BT 436.932 216.156 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 439.341 213.775 Td /F4 8.7 Tf [(3)] TJ ET 0.271 0.267 0.267 rg BT 444.160 216.156 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 446.569 213.775 Td /F4 8.7 Tf [(4)] TJ ET 0.271 0.267 0.267 rg BT 451.388 216.156 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 453.797 213.775 Td /F4 8.7 Tf [(5)] TJ ET 0.271 0.267 0.267 rg BT 458.616 212.268 Td /F1 9.8 Tf [(. The cognitive )] TJ ET BT 26.250 200.363 Td /F1 9.8 Tf [(deterioration in HD is thought to be related to dysfunction of the frontostriatal circuits due to gradual degeneration of the striatum)] TJ ET 0.267 0.267 0.267 rg BT 26.250 189.965 Td /F4 8.7 Tf [(6)] TJ ET 0.271 0.267 0.267 rg BT 31.069 192.346 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 33.478 189.965 Td /F4 8.7 Tf [(7)] TJ ET 0.271 0.267 0.267 rg BT 38.297 188.458 Td /F1 9.8 Tf [(. Accordingly, the first signs of cognitive impairment are observed in cognitive functions associated with the prefrontal cortex )] TJ ET BT 26.250 176.553 Td /F1 9.8 Tf [(such as executive functions and social cognitive functions)] TJ ET 0.267 0.267 0.267 rg BT 274.992 178.061 Td /F4 8.7 Tf [(4)] TJ ET 0.271 0.267 0.267 rg BT 279.811 180.442 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 282.220 178.061 Td /F4 8.7 Tf [(8)] TJ ET 0.271 0.267 0.267 rg BT 287.039 180.442 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 289.448 178.061 Td /F4 8.7 Tf [(9)] TJ ET 0.271 0.267 0.267 rg BT 294.267 180.442 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 296.676 178.061 Td /F4 8.7 Tf [(10)] TJ ET 0.271 0.267 0.267 rg BT 306.313 176.553 Td /F1 9.8 Tf [(. Psychiatric symptoms are also commonly found even in the )] TJ ET BT 26.250 164.649 Td /F1 9.8 Tf [(presymptomatic and earliest stages in HD, and a wide variety of psychiatric symptoms such as apathy, depression, irritability, )] TJ ET BT 26.250 152.744 Td /F1 9.8 Tf [(anxiety, mania and obsessive compulsive symptoms can be seen)] TJ ET 0.267 0.267 0.267 rg BT 308.571 154.251 Td /F4 8.7 Tf [(11)] TJ ET 0.271 0.267 0.267 rg BT 318.208 152.744 Td /F1 9.8 Tf [(.)] TJ ET BT 26.250 133.339 Td /F1 9.8 Tf [(Performance on tests of social cognition and executive functions are often affected by psychopathology. Associations between )] TJ ET BT 26.250 121.434 Td /F1 9.8 Tf [(social cognitive functions, executive functions and psychiatric symptoms have been investigated in both psychiatric and )] TJ ET BT 26.250 109.530 Td /F1 9.8 Tf [(neurological disorders such as schizophrenia, depression, bipolar disorder, Parkinsons disease \(PD\) and frontotemporal )] TJ ET BT 26.250 97.625 Td /F1 9.8 Tf [(dementia \(FTD\))] TJ ET 0.267 0.267 0.267 rg BT 94.510 99.132 Td /F4 8.7 Tf [(12)] TJ ET 0.271 0.267 0.267 rg BT 104.147 101.513 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 106.556 99.132 Td /F4 8.7 Tf [(13)] TJ ET 0.271 0.267 0.267 rg BT 116.194 101.513 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 118.603 99.132 Td /F4 8.7 Tf [(14)] TJ ET 0.271 0.267 0.267 rg BT 128.240 101.513 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 130.650 99.132 Td /F4 8.7 Tf [(15)] TJ ET 0.271 0.267 0.267 rg BT 140.287 101.513 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 142.696 99.132 Td /F4 8.7 Tf [(16)] TJ ET 0.271 0.267 0.267 rg BT 152.334 101.513 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 154.743 99.132 Td /F4 8.7 Tf [(17)] TJ ET 0.271 0.267 0.267 rg BT 164.380 101.513 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 166.790 99.132 Td /F4 8.7 Tf [(18)] TJ ET 0.271 0.267 0.267 rg BT 176.427 97.625 Td /F1 9.8 Tf [(. The most common finding being that greater degree of psychiatric symptoms are )] TJ ET BT 26.250 85.720 Td /F1 9.8 Tf [(associated to worse performance on tests of executive functions and social cognition.)] TJ ET BT 26.250 66.315 Td /F1 9.8 Tf [(In two previous studies we have investigated performance on tests of executive functions and social cognition in a large cohort )] TJ ET BT 26.250 54.411 Td /F1 9.8 Tf [(of HD patients in early-moderate disease stage and found a high frequency of impaired performances on tests of executive )] TJ ET BT 26.250 42.506 Td /F1 9.8 Tf [(functions and social cognition)] TJ ET 0.267 0.267 0.267 rg BT 153.605 44.013 Td /F4 8.7 Tf [(2)] TJ ET 0.271 0.267 0.267 rg BT 158.423 46.394 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 160.833 44.013 Td /F4 8.7 Tf [(4)] TJ ET 0.271 0.267 0.267 rg BT 165.651 42.506 Td /F1 9.8 Tf [(. Based on the associations between the presence of psychiatric symptoms and impairments in )] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(1)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Huntington Disease)] TJ ET Q endstream endobj 8 0 obj << /Type /Font /Subtype /Type1 /Name /F1 /BaseFont /Helvetica /Encoding /WinAnsiEncoding >> endobj 9 0 obj << /Type /Font /Subtype /Type1 /Name /F2 /BaseFont /Times-Bold /Encoding /WinAnsiEncoding >> endobj 10 0 obj << /Type /Font /Subtype /Type1 /Name /F3 /BaseFont /Times-Italic /Encoding /WinAnsiEncoding >> endobj 11 0 obj << /Type /Font /Subtype /Type1 /Name /F4 /BaseFont /Helvetica-Bold /Encoding /WinAnsiEncoding >> endobj 12 0 obj << /Type /XObject /Subtype /Image /Width 500 /Height 52 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 500 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 144>> stream x1 0 'ݲ؎"e{dzAdzAdzAdzAdzAdzAdzAdzAdzAdzAdzAdzAtlM0\ endstream endobj 13 0 obj << /Type /XObject /Subtype /Image /Width 500 /Height 52 /SMask 12 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 500 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 4223>> stream xە8=,8C#h!hGv#0=j$q1uaNĥT*J&a_Zaa0 a0 a0 H^UUUUX!0 3SY|^G0 ÌÔ{]wa_>"OeYaG!8e}a6̖{4M&d:"qʲ\QUUMS<ϛNld2l6Z a<=2B(2vK7M\.GW0 rrWWavߖe9C?Eq8Gqy~~}_qdϽ(neYʒGjK4EQNjͷm{X?|7m۶mqP:Ȳp8Kmu]lNzuZ,NTeY"jlUUQW\,aRiVbȗLkHkEsjd.L6=Iו P]1t7Sc2uIuMM; K5>A$Ǒ$I׋nY 0_Hat;aq䃰U$nR ,zO7bT mhhԫܻu1F*qm'P}ܙ<ϕALO6Lw3nB.T4co{߽.lV $laԀIu!gwChxJ]Ne (+M"d-Eqc=P ! "nf(7>ce,Řm[!ʝD!m)Bs@)ta3}g˲}ZbշONKFp倫Rg(,I2 C%5y B v o9϶m+ІXcTwV5;8dHF{7Qm6'N۠%$HSMk!D4i:ŕS*bS̹"2=ԓH51$UfZVtli<0]nDZlcWv;LQrxhk+},CVeD8]ې/.m[nc)2XAOMo&}"&ڨv宇EqX$tcGc,|`5)yO(U\͠&ԭC&~1ynKoC~kqqltV\4M8NTre#sT|>+GJ W]$Ii EMHdD70_ rEЀa:c4u U0.RH=SN4/z2pȤfx$]1 wt<]׭U$%=wi~ܮ{=×w\Բ!s^__=Axa1|=(l´i4MEUUm6y)~E5UU~gѥJ'+WTN'!H>{=nytH{{xzo<8aOw0lN]? gNR2Ɍ6Z摤Ww(eYv̲ b\aHɟ,J6 ܺ= ^'ҵ4^.˲rIaJ'RC]Qѯr洱lf?>ȩ_Ye=3ʆ:Fy0D&y%0zU^5ἧԯgFeYqƈhz#ms[o$+0Qz2-Z\"#f29:WGVzlBPD;CW+Dye$ 6HQ"\&_$Tp]Ah eHyR1' p'sD)ZDpB/Y_SVGӌ;Oo[Am+(Uܮ+UʽN=PJ/>^;?9ogmYѲ=k@._ (V{#z/,@Y,1e`& i$<=EQl6|A4b%'X[ѶaSh/QM&$NgSٲ,奭ֻDH>EeSFo['ķriVa߶ ї5,lj* QÈ=TqEMD 4N6MCL(PƯ%n^ w~oSrDfe0^F]G$IY?v+rEQ-WUmpP^ :vz֝2q#3Dƾt: ~Gv(,$j:NpCˏS)=ϛL&xlۆ+i8}CH,t%z\MD 0 ^tC>(4;ن]螞Pt:5f[@oqg{L̷gYD"maI4coKE殂 'ٲt2_,m[|QafLuDZ( W 5oOiy{0oqNF;rj%zwuo10)BwܮC!}Έ3H(.E' h]jDA 6.M T8zqy~oeO#]PWp0<;F܆b+ɽnKQy\8nڶd/خ^^o|N.[vOz`'Ef̈+""/cL<" Ƅ_~W|¿Tt"fiY_uWx<ŠM(0L891a>ao\|[C~mX3 3;o6|>ϻ#ChR0 Ì`r뚢#~#N*0 Fk%ʪrOd6u͊Akdfwܧ),Y0 ܡܛ4ۈa 0 -0 )rgrgrgrgzm endstream endobj 14 0 obj << /Type /Annot /Subtype /Link /A 15 0 R /Border [0 0 0] /H /I /Rect [ 15.0000 716.1516 530.6760 736.9416 ] >> endobj 15 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/article/comfortably-numb-social-cognition-executive-functions-and-self-report-of-psychological-distress-in-huntingtons-disease/) >> endobj 16 0 obj << /Type /Annot /Subtype /Link /A 17 0 R /Border [0 0 0] /H /I /Rect [ 15.0000 691.2036 431.5140 711.9936 ] >> endobj 17 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/article/comfortably-numb-social-cognition-executive-functions-and-self-report-of-psychological-distress-in-huntingtons-disease/) >> endobj 18 0 obj << /Type /Annot /Subtype /Link /A 19 0 R /Border [0 0 0] /H /I /Rect [ 101.3752 674.2101 166.6320 683.8626 ] >> endobj 19 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/article_category/research-article/) >> endobj 20 0 obj << /Type /Annot /Subtype /Link /A 21 0 R /Border [0 0 0] /H /I /Rect [ 26.2500 662.3453 110.7825 672.2659 ] >> endobj 21 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/author/idaunmack/) >> endobj 22 0 obj << /Type /Annot /Subtype /Link /A 23 0 R /Border [0 0 0] /H /I /Rect [ 116.2035 662.3453 201.2820 672.2659 ] >> endobj 23 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/author/tuavinthergmail-com/) >> endobj 24 0 obj << /Type /Annot /Subtype /Link /A 25 0 R /Border [0 0 0] /H /I /Rect [ 206.7030 662.3453 291.7620 672.2659 ] >> endobj 25 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/author/jorgenenielsen/) >> endobj 26 0 obj << /Type /Annot /Subtype /Link /A 27 0 R /Border [0 0 0] /H /I /Rect [ 297.1830 662.3453 354.6300 672.2659 ] >> endobj 27 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/author/anders-gadepsy-ku-dk/) >> endobj 28 0 obj << /Type /Annot /Subtype /Link /A 29 0 R /Border [0 0 0] /H /I /Rect [ 360.0510 662.3453 417.4882 672.2659 ] >> endobj 29 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/author/asmus-vogel-01regionh-dk/) >> endobj 30 0 obj << /Type /Annot /Subtype /Link /A 31 0 R /Border [0 0 0] /H /I /Rect [ 134.6310 224.8779 139.4497 233.6963 ] >> endobj 31 0 obj << /Type /Action >> endobj 32 0 obj << /Type /Annot /Subtype /Link /A 33 0 R /Border [0 0 0] /H /I /Rect [ 432.1132 212.9732 436.9319 221.7915 ] >> endobj 33 0 obj << /Type /Action >> endobj 34 0 obj << /Type /Annot /Subtype /Link /A 35 0 R /Border [0 0 0] /H /I /Rect [ 439.3413 212.9732 444.1599 221.7915 ] >> endobj 35 0 obj << /Type /Action >> endobj 36 0 obj << /Type /Annot /Subtype /Link /A 37 0 R /Border [0 0 0] /H /I /Rect [ 446.5693 212.9732 451.3879 221.7915 ] >> endobj 37 0 obj << /Type /Action >> endobj 38 0 obj << /Type /Annot /Subtype /Link /A 39 0 R /Border [0 0 0] /H /I /Rect [ 453.7973 212.9732 458.6159 221.7915 ] >> endobj 39 0 obj << /Type /Action >> endobj 40 0 obj << /Type /Annot /Subtype /Link /A 41 0 R /Border [0 0 0] /H /I /Rect [ 26.2500 189.1637 31.0687 197.9820 ] >> endobj 41 0 obj << /Type /Action >> endobj 42 0 obj << /Type /Annot /Subtype /Link /A 43 0 R /Border [0 0 0] /H /I /Rect [ 33.4780 189.1637 38.2967 197.9820 ] >> endobj 43 0 obj << /Type /Action >> endobj 44 0 obj << /Type /Annot /Subtype /Link /A 45 0 R /Border [0 0 0] /H /I /Rect [ 274.9920 177.2589 279.8107 186.0772 ] >> endobj 45 0 obj << /Type /Action >> endobj 46 0 obj << /Type /Annot /Subtype /Link /A 47 0 R /Border [0 0 0] /H /I /Rect [ 282.2200 177.2589 287.0387 186.0772 ] >> endobj 47 0 obj << /Type /Action >> endobj 48 0 obj << /Type /Annot /Subtype /Link /A 49 0 R /Border [0 0 0] /H /I /Rect [ 289.4480 177.2589 294.2667 186.0772 ] >> endobj 49 0 obj << /Type /Action >> endobj 50 0 obj << /Type /Annot /Subtype /Link /A 51 0 R /Border [0 0 0] /H /I /Rect [ 296.6760 177.2589 306.3133 186.0772 ] >> endobj 51 0 obj << /Type /Action >> endobj 52 0 obj << /Type /Annot /Subtype /Link /A 53 0 R /Border [0 0 0] /H /I /Rect [ 308.5710 153.4494 318.2083 162.2677 ] >> endobj 53 0 obj << /Type /Action >> endobj 54 0 obj << /Type /Annot /Subtype /Link /A 55 0 R /Border [0 0 0] /H /I /Rect [ 94.5097 98.3304 104.1471 107.1487 ] >> endobj 55 0 obj << /Type /Action >> endobj 56 0 obj << /Type /Annot /Subtype /Link /A 57 0 R /Border [0 0 0] /H /I /Rect [ 106.5564 98.3304 116.1938 107.1487 ] >> endobj 57 0 obj << /Type /Action >> endobj 58 0 obj << /Type /Annot /Subtype /Link /A 59 0 R /Border [0 0 0] /H /I /Rect [ 118.6031 98.3304 128.2404 107.1487 ] >> endobj 59 0 obj << /Type /Action >> endobj 60 0 obj << /Type /Annot /Subtype /Link /A 61 0 R /Border [0 0 0] /H /I /Rect [ 130.6498 98.3304 140.2871 107.1487 ] >> endobj 61 0 obj << /Type /Action >> endobj 62 0 obj << /Type /Annot /Subtype /Link /A 63 0 R /Border [0 0 0] /H /I /Rect [ 142.6964 98.3304 152.3338 107.1487 ] >> endobj 63 0 obj << /Type /Action >> endobj 64 0 obj << /Type /Annot /Subtype /Link /A 65 0 R /Border [0 0 0] /H /I /Rect [ 154.7431 98.3304 164.3804 107.1487 ] >> endobj 65 0 obj << /Type /Action >> endobj 66 0 obj << /Type /Annot /Subtype /Link /A 67 0 R /Border [0 0 0] /H /I /Rect [ 166.7898 98.3304 176.4271 107.1487 ] >> endobj 67 0 obj << /Type /Action >> endobj 68 0 obj << /Type /Annot /Subtype /Link /A 69 0 R /Border [0 0 0] /H /I /Rect [ 153.6045 43.2114 158.4232 52.0297 ] >> endobj 69 0 obj << /Type /Action >> endobj 70 0 obj << /Type /Annot /Subtype /Link /A 71 0 R /Border [0 0 0] /H /I /Rect [ 160.8325 43.2114 165.6512 52.0297 ] >> endobj 71 0 obj << /Type /Action >> endobj 72 0 obj << /Type /Annot /Subtype /Link /A 73 0 R /Border [0 0 0] /H /I /Rect [ 15.0000 716.1516 530.6760 736.9416 ] >> endobj 73 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/article/comfortably-numb-social-cognition-executive-functions-and-self-report-of-psychological-distress-in-huntingtons-disease/) >> endobj 74 0 obj << /Type /Annot /Subtype /Link /A 75 0 R /Border [0 0 0] /H /I /Rect [ 15.0000 691.2036 431.5140 711.9936 ] >> endobj 75 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/article/comfortably-numb-social-cognition-executive-functions-and-self-report-of-psychological-distress-in-huntingtons-disease/) >> endobj 76 0 obj << /Type /Annot /Subtype /Link /A 77 0 R /Border [0 0 0] /H /I /Rect [ 101.3752 674.2101 166.6320 683.8626 ] >> endobj 77 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/article_category/research-article/) >> endobj 78 0 obj << /Type /Annot /Subtype /Link /A 79 0 R /Border [0 0 0] /H /I /Rect [ 26.2500 662.3453 110.7825 672.2659 ] >> endobj 79 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/author/idaunmack/) >> endobj 80 0 obj << /Type /Annot /Subtype /Link /A 81 0 R /Border [0 0 0] /H /I /Rect [ 116.2035 662.3453 201.2820 672.2659 ] >> endobj 81 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/author/tuavinthergmail-com/) >> endobj 82 0 obj << /Type /Annot /Subtype /Link /A 83 0 R /Border [0 0 0] /H /I /Rect [ 206.7030 662.3453 291.7620 672.2659 ] >> endobj 83 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/author/jorgenenielsen/) >> endobj 84 0 obj << /Type /Annot /Subtype /Link /A 85 0 R /Border [0 0 0] /H /I /Rect [ 297.1830 662.3453 354.6300 672.2659 ] >> endobj 85 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/author/anders-gadepsy-ku-dk/) >> endobj 86 0 obj << /Type /Annot /Subtype /Link /A 87 0 R /Border [0 0 0] /H /I /Rect [ 360.0510 662.3453 417.4882 672.2659 ] >> endobj 87 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/author/asmus-vogel-01regionh-dk/) >> endobj 88 0 obj << /Type /Annot /Subtype /Link /A 89 0 R /Border [0 0 0] /H /I /Rect [ 134.6310 224.8779 139.4497 233.6963 ] >> endobj 89 0 obj << /Type /Action >> endobj 90 0 obj << /Type /Annot /Subtype /Link /A 91 0 R /Border [0 0 0] /H /I /Rect [ 432.1132 212.9732 436.9319 221.7915 ] >> endobj 91 0 obj << /Type /Action >> endobj 92 0 obj << /Type /Annot /Subtype /Link /A 93 0 R /Border [0 0 0] /H /I /Rect [ 439.3413 212.9732 444.1599 221.7915 ] >> endobj 93 0 obj << /Type /Action >> endobj 94 0 obj << /Type /Annot /Subtype /Link /A 95 0 R /Border [0 0 0] /H /I /Rect [ 446.5693 212.9732 451.3879 221.7915 ] >> endobj 95 0 obj << /Type /Action >> endobj 96 0 obj << /Type /Annot /Subtype /Link /A 97 0 R /Border [0 0 0] /H /I /Rect [ 453.7973 212.9732 458.6159 221.7915 ] >> endobj 97 0 obj << /Type /Action >> endobj 98 0 obj << /Type /Annot /Subtype /Link /A 99 0 R /Border [0 0 0] /H /I /Rect [ 26.2500 189.1637 31.0687 197.9820 ] >> endobj 99 0 obj << /Type /Action >> endobj 100 0 obj << /Type /Annot /Subtype /Link /A 101 0 R /Border [0 0 0] /H /I /Rect [ 33.4780 189.1637 38.2967 197.9820 ] >> endobj 101 0 obj << /Type /Action >> endobj 102 0 obj << /Type /Annot /Subtype /Link /A 103 0 R /Border [0 0 0] /H /I /Rect [ 274.9920 177.2589 279.8107 186.0772 ] >> endobj 103 0 obj << /Type /Action >> endobj 104 0 obj << /Type /Annot /Subtype /Link /A 105 0 R /Border [0 0 0] /H /I /Rect [ 282.2200 177.2589 287.0387 186.0772 ] >> endobj 105 0 obj << /Type /Action >> endobj 106 0 obj << /Type /Annot /Subtype /Link /A 107 0 R /Border [0 0 0] /H /I /Rect [ 289.4480 177.2589 294.2667 186.0772 ] >> endobj 107 0 obj << /Type /Action >> endobj 108 0 obj << /Type /Annot /Subtype /Link /A 109 0 R /Border [0 0 0] /H /I /Rect [ 296.6760 177.2589 306.3133 186.0772 ] >> endobj 109 0 obj << /Type /Action >> endobj 110 0 obj << /Type /Annot /Subtype /Link /A 111 0 R /Border [0 0 0] /H /I /Rect [ 308.5710 153.4494 318.2083 162.2677 ] >> endobj 111 0 obj << /Type /Action >> endobj 112 0 obj << /Type /Annot /Subtype /Link /A 113 0 R /Border [0 0 0] /H /I /Rect [ 94.5097 98.3304 104.1471 107.1487 ] >> endobj 113 0 obj << /Type /Action >> endobj 114 0 obj << /Type /Annot /Subtype /Link /A 115 0 R /Border [0 0 0] /H /I /Rect [ 106.5564 98.3304 116.1938 107.1487 ] >> endobj 115 0 obj << /Type /Action >> endobj 116 0 obj << /Type /Annot /Subtype /Link /A 117 0 R /Border [0 0 0] /H /I /Rect [ 118.6031 98.3304 128.2404 107.1487 ] >> endobj 117 0 obj << /Type /Action >> endobj 118 0 obj << /Type /Annot /Subtype /Link /A 119 0 R /Border [0 0 0] /H /I /Rect [ 130.6498 98.3304 140.2871 107.1487 ] >> endobj 119 0 obj << /Type /Action >> endobj 120 0 obj << /Type /Annot /Subtype /Link /A 121 0 R /Border [0 0 0] /H /I /Rect [ 142.6964 98.3304 152.3338 107.1487 ] >> endobj 121 0 obj << /Type /Action >> endobj 122 0 obj << /Type /Annot /Subtype /Link /A 123 0 R /Border [0 0 0] /H /I /Rect [ 154.7431 98.3304 164.3804 107.1487 ] >> endobj 123 0 obj << /Type /Action >> endobj 124 0 obj << /Type /Annot /Subtype /Link /A 125 0 R /Border [0 0 0] /H /I /Rect [ 166.7898 98.3304 176.4271 107.1487 ] >> endobj 125 0 obj << /Type /Action >> endobj 126 0 obj << /Type /Annot /Subtype /Link /A 127 0 R /Border [0 0 0] /H /I /Rect [ 153.6045 43.2114 158.4232 52.0297 ] >> endobj 127 0 obj << /Type /Action >> endobj 128 0 obj << /Type /Annot /Subtype /Link /A 129 0 R /Border [0 0 0] /H /I /Rect [ 160.8325 43.2114 165.6512 52.0297 ] >> endobj 129 0 obj << /Type /Action >> endobj 130 0 obj << /Type /Annot /Subtype /Link /A 131 0 R /Border [0 0 0] /H /I /Rect [ 15.0000 716.1516 530.6760 736.9416 ] >> endobj 131 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/article/comfortably-numb-social-cognition-executive-functions-and-self-report-of-psychological-distress-in-huntingtons-disease/) >> endobj 132 0 obj << /Type /Annot /Subtype /Link /A 133 0 R /Border [0 0 0] /H /I /Rect [ 15.0000 691.2036 431.5140 711.9936 ] >> endobj 133 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/article/comfortably-numb-social-cognition-executive-functions-and-self-report-of-psychological-distress-in-huntingtons-disease/) >> endobj 134 0 obj << /Type /Annot /Subtype /Link /A 135 0 R /Border [0 0 0] /H /I /Rect [ 101.3752 674.2101 166.6320 683.8626 ] >> endobj 135 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/article_category/research-article/) >> endobj 136 0 obj << /Type /Annot /Subtype /Link /A 137 0 R /Border [0 0 0] /H /I /Rect [ 26.2500 662.3453 110.7825 672.2659 ] >> endobj 137 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/author/idaunmack/) >> endobj 138 0 obj << /Type /Annot /Subtype /Link /A 139 0 R /Border [0 0 0] /H /I /Rect [ 116.2035 662.3453 201.2820 672.2659 ] >> endobj 139 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/author/tuavinthergmail-com/) >> endobj 140 0 obj << /Type /Annot /Subtype /Link /A 141 0 R /Border [0 0 0] /H /I /Rect [ 206.7030 662.3453 291.7620 672.2659 ] >> endobj 141 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/author/jorgenenielsen/) >> endobj 142 0 obj << /Type /Annot /Subtype /Link /A 143 0 R /Border [0 0 0] /H /I /Rect [ 297.1830 662.3453 354.6300 672.2659 ] >> endobj 143 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/author/anders-gadepsy-ku-dk/) >> endobj 144 0 obj << /Type /Annot /Subtype /Link /A 145 0 R /Border [0 0 0] /H /I /Rect [ 360.0510 662.3453 417.4882 672.2659 ] >> endobj 145 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/author/asmus-vogel-01regionh-dk/) >> endobj 146 0 obj << /Type /Annot /Subtype /Link /A 147 0 R /Border [0 0 0] /H /I /Rect [ 134.6310 224.8779 139.4497 233.6963 ] >> endobj 147 0 obj << /Type /Action >> endobj 148 0 obj << /Type /Annot /Subtype /Link /A 149 0 R /Border [0 0 0] /H /I /Rect [ 432.1132 212.9732 436.9319 221.7915 ] >> endobj 149 0 obj << /Type /Action >> endobj 150 0 obj << /Type /Annot /Subtype /Link /A 151 0 R /Border [0 0 0] /H /I /Rect [ 439.3413 212.9732 444.1599 221.7915 ] >> endobj 151 0 obj << /Type /Action >> endobj 152 0 obj << /Type /Annot /Subtype /Link /A 153 0 R /Border [0 0 0] /H /I /Rect [ 446.5693 212.9732 451.3879 221.7915 ] >> endobj 153 0 obj << /Type /Action >> endobj 154 0 obj << /Type /Annot /Subtype /Link /A 155 0 R /Border [0 0 0] /H /I /Rect [ 453.7973 212.9732 458.6159 221.7915 ] >> endobj 155 0 obj << /Type /Action >> endobj 156 0 obj << /Type /Annot /Subtype /Link /A 157 0 R /Border [0 0 0] /H /I /Rect [ 26.2500 189.1637 31.0687 197.9820 ] >> endobj 157 0 obj << /Type /Action >> endobj 158 0 obj << /Type /Annot /Subtype /Link /A 159 0 R /Border [0 0 0] /H /I /Rect [ 33.4780 189.1637 38.2967 197.9820 ] >> endobj 159 0 obj << /Type /Action >> endobj 160 0 obj << /Type /Annot /Subtype /Link /A 161 0 R /Border [0 0 0] /H /I /Rect [ 274.9920 177.2589 279.8107 186.0772 ] >> endobj 161 0 obj << /Type /Action >> endobj 162 0 obj << /Type /Annot /Subtype /Link /A 163 0 R /Border [0 0 0] /H /I /Rect [ 282.2200 177.2589 287.0387 186.0772 ] >> endobj 163 0 obj << /Type /Action >> endobj 164 0 obj << /Type /Annot /Subtype /Link /A 165 0 R /Border [0 0 0] /H /I /Rect [ 289.4480 177.2589 294.2667 186.0772 ] >> endobj 165 0 obj << /Type /Action >> endobj 166 0 obj << /Type /Annot /Subtype /Link /A 167 0 R /Border [0 0 0] /H /I /Rect [ 296.6760 177.2589 306.3133 186.0772 ] >> endobj 167 0 obj << /Type /Action >> endobj 168 0 obj << /Type /Annot /Subtype /Link /A 169 0 R /Border [0 0 0] /H /I /Rect [ 308.5710 153.4494 318.2083 162.2677 ] >> endobj 169 0 obj << /Type /Action >> endobj 170 0 obj << /Type /Annot /Subtype /Link /A 171 0 R /Border [0 0 0] /H /I /Rect [ 94.5097 98.3304 104.1471 107.1487 ] >> endobj 171 0 obj << /Type /Action >> endobj 172 0 obj << /Type /Annot /Subtype /Link /A 173 0 R /Border [0 0 0] /H /I /Rect [ 106.5564 98.3304 116.1938 107.1487 ] >> endobj 173 0 obj << /Type /Action >> endobj 174 0 obj << /Type /Annot /Subtype /Link /A 175 0 R /Border [0 0 0] /H /I /Rect [ 118.6031 98.3304 128.2404 107.1487 ] >> endobj 175 0 obj << /Type /Action >> endobj 176 0 obj << /Type /Annot /Subtype /Link /A 177 0 R /Border [0 0 0] /H /I /Rect [ 130.6498 98.3304 140.2871 107.1487 ] >> endobj 177 0 obj << /Type /Action >> endobj 178 0 obj << /Type /Annot /Subtype /Link /A 179 0 R /Border [0 0 0] /H /I /Rect [ 142.6964 98.3304 152.3338 107.1487 ] >> endobj 179 0 obj << /Type /Action >> endobj 180 0 obj << /Type /Annot /Subtype /Link /A 181 0 R /Border [0 0 0] /H /I /Rect [ 154.7431 98.3304 164.3804 107.1487 ] >> endobj 181 0 obj << /Type /Action >> endobj 182 0 obj << /Type /Annot /Subtype /Link /A 183 0 R /Border [0 0 0] /H /I /Rect [ 166.7898 98.3304 176.4271 107.1487 ] >> endobj 183 0 obj << /Type /Action >> endobj 184 0 obj << /Type /Annot /Subtype /Link /A 185 0 R /Border [0 0 0] /H /I /Rect [ 153.6045 43.2114 158.4232 52.0297 ] >> endobj 185 0 obj << /Type /Action >> endobj 186 0 obj << /Type /Annot /Subtype /Link /A 187 0 R /Border [0 0 0] /H /I /Rect [ 160.8325 43.2114 165.6512 52.0297 ] >> endobj 187 0 obj << /Type /Action >> endobj 188 0 obj << /Type /Page /Parent 3 0 R /Annots [ 190 0 R 192 0 R 194 0 R 196 0 R 198 0 R 200 0 R 202 0 R 205 0 R 207 0 R 209 0 R 211 0 R 213 0 R 215 0 R 217 0 R 219 0 R 221 0 R 223 0 R 225 0 R 227 0 R 229 0 R 231 0 R ] /Contents 189 0 R >> endobj 189 0 obj << /Length 17202 >> stream 0.271 0.267 0.267 rg q 15.000 26.969 577.500 750.031 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(executive functions and social cognition found in other patient groups we wanted to investigate how subjective experience of )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(psychological distress as reported by patients with Huntingtons disease is related to performance on tests of social cognition )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(and executive functions.)] TJ ET BT 26.250 724.262 Td /F1 9.8 Tf [(Therefore the aim of this study was to investigate the relationship between self-report of perceived psychological distress and )] TJ ET BT 26.250 712.357 Td /F1 9.8 Tf [(performances on a battery of tests of executive functions and social cognition in a large consecutive cohort of HD patients. We )] TJ ET BT 26.250 700.452 Td /F1 9.8 Tf [(wanted to investigate: 1\) whether performances on tests of social cognition and executive functions are correlated, and 2\) )] TJ ET BT 26.250 688.548 Td /F1 9.8 Tf [(whether performances on tests of social cognition and executive functions are associated with degree of self-reported )] TJ ET BT 26.250 676.643 Td /F1 9.8 Tf [(psychological distress. To our knowledge, this is the first study to compare performance on a large battery of tests of social )] TJ ET BT 26.250 664.738 Td /F1 9.8 Tf [(cognition and executive functions to self-report of psychological distress in HD.)] TJ ET BT 26.250 628.136 Td /F4 12.0 Tf [(Methods)] TJ ET BT 26.250 608.181 Td /F4 9.8 Tf [(Participants)] TJ ET BT 26.250 588.777 Td /F1 9.8 Tf [(Participants were recruited from January 2012 to March 2013 from the Neurogenetics Clinic, Danish Dementia Research )] TJ ET BT 26.250 576.872 Td /F1 9.8 Tf [(Centre, Rigshospitalet. Fifty HD patients with a CAG repeat ?39, a Unified Huntingtons Disease Rating Scale-99 total motor )] TJ ET BT 26.250 564.967 Td /F1 9.8 Tf [(score \(UHDRS-TMS\) of >5)] TJ ET 0.267 0.267 0.267 rg BT 142.451 566.474 Td /F4 8.7 Tf [(19)] TJ ET 0.271 0.267 0.267 rg BT 152.088 564.967 Td /F1 9.8 Tf [(, a Mini-Mental State Examination \(MMSE\) score ? 24, and a Montreal Cognitive Assessment )] TJ ET BT 26.250 553.062 Td /F1 9.8 Tf [(\(MoCA\))] TJ ET 0.267 0.267 0.267 rg BT 59.829 554.570 Td /F4 8.7 Tf [(20)] TJ ET 0.271 0.267 0.267 rg BT 69.466 553.062 Td /F1 9.8 Tf [( score ? 20 were included in the study. Exclusion criteria were other neurological illness, ongoing alcohol or drug )] TJ ET BT 26.250 541.158 Td /F1 9.8 Tf [(abuse and having a native language other than Danish. Table 1 shows the background information for the HD patients. All )] TJ ET BT 26.250 529.253 Td /F1 9.8 Tf [(patients had gone through genetic counseling and had been informed of their genetic status prior to \(and independently from\) )] TJ ET BT 26.250 517.348 Td /F1 9.8 Tf [(study enrolment. We have previously published results from the same cohort)] TJ ET 0.267 0.267 0.267 rg BT 356.795 518.855 Td /F4 8.7 Tf [(2)] TJ ET 0.271 0.267 0.267 rg BT 361.613 521.236 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 364.023 518.855 Td /F4 8.7 Tf [(4)] TJ ET 0.271 0.267 0.267 rg BT 368.841 521.236 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 371.251 518.855 Td /F4 8.7 Tf [(5)] TJ ET 0.271 0.267 0.267 rg BT 376.069 521.236 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 378.479 518.855 Td /F4 8.7 Tf [(21)] TJ ET 0.271 0.267 0.267 rg BT 388.116 517.348 Td /F1 9.8 Tf [( also including premanifest HD carriers, but )] TJ ET BT 26.250 505.443 Td /F1 9.8 Tf [(since we found no impairments in social cognitive functions in our premanifest subjects we did not include them in the present )] TJ ET BT 26.250 493.539 Td /F1 9.8 Tf [(study.)] TJ ET 0.965 0.965 0.965 rg 26.250 187.921 555.000 295.736 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 483.658 m 581.250 483.658 l 581.250 482.908 l 26.250 482.908 l f 26.250 187.921 m 581.250 187.921 l 581.250 188.671 l 26.250 188.671 l f q 450.000 0 0 247.500 35.250 226.408 cm /I3 Do Q q 35.250 199.171 537.000 21.236 re W n 0.271 0.267 0.267 rg BT 35.250 209.419 Td /F4 9.8 Tf [(Table 1.)] TJ ET BT 71.559 209.419 Td /F1 9.8 Tf [( Background information. Results shown as median \(range\))] TJ ET Q BT 26.250 170.898 Td /F4 9.8 Tf [(Procedure)] TJ ET BT 26.250 151.493 Td /F1 9.8 Tf [(The study was approved by the Ethics Committee of the Capital Region of Denmark\(H2-2011-085\), and written informed )] TJ ET BT 26.250 139.588 Td /F1 9.8 Tf [(consent was obtained from each participant before enrollment. All participants had a minimum of two planned visits. At one visit )] TJ ET BT 26.250 127.683 Td /F1 9.8 Tf [(psychiatric screening and neurological examinations were performed. At the other visit neuropsychological testing was )] TJ ET BT 26.250 115.779 Td /F1 9.8 Tf [(performed. The same physician and the same neuropsychologist performed all examinations. The examination by the physician )] TJ ET BT 26.250 103.874 Td /F1 9.8 Tf [(and the examination by the neuropsychologist were performed blinded to one another.)] TJ ET BT 26.250 84.469 Td /F4 9.8 Tf [(Neuropsychological Testing)] TJ ET BT 26.250 65.064 Td /F1 9.8 Tf [(All participants were tested with an extensive three-hour battery of neuropsychological tests, including tests of attention, )] TJ ET BT 26.250 53.160 Td /F1 9.8 Tf [(memory, visuospatial functions, executive functions and social cognition. For this study only tests of executive functions and )] TJ ET BT 26.250 41.255 Td /F1 9.8 Tf [(tests of social cognition are included. The tests were administered in a fixed order. The education index score \(range 8-17\) was )] TJ ET Q q 15.000 26.969 577.500 750.031 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(executive functions and social cognition found in other patient groups we wanted to investigate how subjective experience of )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(psychological distress as reported by patients with Huntingtons disease is related to performance on tests of social cognition )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(and executive functions.)] TJ ET BT 26.250 724.262 Td /F1 9.8 Tf [(Therefore the aim of this study was to investigate the relationship between self-report of perceived psychological distress and )] TJ ET BT 26.250 712.357 Td /F1 9.8 Tf [(performances on a battery of tests of executive functions and social cognition in a large consecutive cohort of HD patients. We )] TJ ET BT 26.250 700.452 Td /F1 9.8 Tf [(wanted to investigate: 1\) whether performances on tests of social cognition and executive functions are correlated, and 2\) )] TJ ET BT 26.250 688.548 Td /F1 9.8 Tf [(whether performances on tests of social cognition and executive functions are associated with degree of self-reported )] TJ ET BT 26.250 676.643 Td /F1 9.8 Tf [(psychological distress. To our knowledge, this is the first study to compare performance on a large battery of tests of social )] TJ ET BT 26.250 664.738 Td /F1 9.8 Tf [(cognition and executive functions to self-report of psychological distress in HD.)] TJ ET BT 26.250 628.136 Td /F4 12.0 Tf [(Methods)] TJ ET BT 26.250 608.181 Td /F4 9.8 Tf [(Participants)] TJ ET BT 26.250 588.777 Td /F1 9.8 Tf [(Participants were recruited from January 2012 to March 2013 from the Neurogenetics Clinic, Danish Dementia Research )] TJ ET BT 26.250 576.872 Td /F1 9.8 Tf [(Centre, Rigshospitalet. Fifty HD patients with a CAG repeat ?39, a Unified Huntingtons Disease Rating Scale-99 total motor )] TJ ET BT 26.250 564.967 Td /F1 9.8 Tf [(score \(UHDRS-TMS\) of >5)] TJ ET 0.267 0.267 0.267 rg BT 142.451 566.474 Td /F4 8.7 Tf [(19)] TJ ET 0.271 0.267 0.267 rg BT 152.088 564.967 Td /F1 9.8 Tf [(, a Mini-Mental State Examination \(MMSE\) score ? 24, and a Montreal Cognitive Assessment )] TJ ET BT 26.250 553.062 Td /F1 9.8 Tf [(\(MoCA\))] TJ ET 0.267 0.267 0.267 rg BT 59.829 554.570 Td /F4 8.7 Tf [(20)] TJ ET 0.271 0.267 0.267 rg BT 69.466 553.062 Td /F1 9.8 Tf [( score ? 20 were included in the study. Exclusion criteria were other neurological illness, ongoing alcohol or drug )] TJ ET BT 26.250 541.158 Td /F1 9.8 Tf [(abuse and having a native language other than Danish. Table 1 shows the background information for the HD patients. All )] TJ ET BT 26.250 529.253 Td /F1 9.8 Tf [(patients had gone through genetic counseling and had been informed of their genetic status prior to \(and independently from\) )] TJ ET BT 26.250 517.348 Td /F1 9.8 Tf [(study enrolment. We have previously published results from the same cohort)] TJ ET 0.267 0.267 0.267 rg BT 356.795 518.855 Td /F4 8.7 Tf [(2)] TJ ET 0.271 0.267 0.267 rg BT 361.613 521.236 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 364.023 518.855 Td /F4 8.7 Tf [(4)] TJ ET 0.271 0.267 0.267 rg BT 368.841 521.236 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 371.251 518.855 Td /F4 8.7 Tf [(5)] TJ ET 0.271 0.267 0.267 rg BT 376.069 521.236 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 378.479 518.855 Td /F4 8.7 Tf [(21)] TJ ET 0.271 0.267 0.267 rg BT 388.116 517.348 Td /F1 9.8 Tf [( also including premanifest HD carriers, but )] TJ ET BT 26.250 505.443 Td /F1 9.8 Tf [(since we found no impairments in social cognitive functions in our premanifest subjects we did not include them in the present )] TJ ET BT 26.250 493.539 Td /F1 9.8 Tf [(study.)] TJ ET 0.965 0.965 0.965 rg 26.250 187.921 555.000 295.736 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 483.658 m 581.250 483.658 l 581.250 482.908 l 26.250 482.908 l f 26.250 187.921 m 581.250 187.921 l 581.250 188.671 l 26.250 188.671 l f q 450.000 0 0 247.500 35.250 226.408 cm /I3 Do Q q 35.250 199.171 537.000 21.236 re W n 0.271 0.267 0.267 rg BT 35.250 209.419 Td /F4 9.8 Tf [(Table 1.)] TJ ET BT 71.559 209.419 Td /F1 9.8 Tf [( Background information. Results shown as median \(range\))] TJ ET Q BT 26.250 170.898 Td /F4 9.8 Tf [(Procedure)] TJ ET BT 26.250 151.493 Td /F1 9.8 Tf [(The study was approved by the Ethics Committee of the Capital Region of Denmark\(H2-2011-085\), and written informed )] TJ ET BT 26.250 139.588 Td /F1 9.8 Tf [(consent was obtained from each participant before enrollment. All participants had a minimum of two planned visits. At one visit )] TJ ET BT 26.250 127.683 Td /F1 9.8 Tf [(psychiatric screening and neurological examinations were performed. At the other visit neuropsychological testing was )] TJ ET BT 26.250 115.779 Td /F1 9.8 Tf [(performed. The same physician and the same neuropsychologist performed all examinations. The examination by the physician )] TJ ET BT 26.250 103.874 Td /F1 9.8 Tf [(and the examination by the neuropsychologist were performed blinded to one another.)] TJ ET BT 26.250 84.469 Td /F4 9.8 Tf [(Neuropsychological Testing)] TJ ET BT 26.250 65.064 Td /F1 9.8 Tf [(All participants were tested with an extensive three-hour battery of neuropsychological tests, including tests of attention, )] TJ ET BT 26.250 53.160 Td /F1 9.8 Tf [(memory, visuospatial functions, executive functions and social cognition. For this study only tests of executive functions and )] TJ ET BT 26.250 41.255 Td /F1 9.8 Tf [(tests of social cognition are included. The tests were administered in a fixed order. The education index score \(range 8-17\) was )] TJ ET Q q 15.000 26.969 577.500 750.031 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(executive functions and social cognition found in other patient groups we wanted to investigate how subjective experience of )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(psychological distress as reported by patients with Huntingtons disease is related to performance on tests of social cognition )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(and executive functions.)] TJ ET BT 26.250 724.262 Td /F1 9.8 Tf [(Therefore the aim of this study was to investigate the relationship between self-report of perceived psychological distress and )] TJ ET BT 26.250 712.357 Td /F1 9.8 Tf [(performances on a battery of tests of executive functions and social cognition in a large consecutive cohort of HD patients. We )] TJ ET BT 26.250 700.452 Td /F1 9.8 Tf [(wanted to investigate: 1\) whether performances on tests of social cognition and executive functions are correlated, and 2\) )] TJ ET BT 26.250 688.548 Td /F1 9.8 Tf [(whether performances on tests of social cognition and executive functions are associated with degree of self-reported )] TJ ET BT 26.250 676.643 Td /F1 9.8 Tf [(psychological distress. To our knowledge, this is the first study to compare performance on a large battery of tests of social )] TJ ET BT 26.250 664.738 Td /F1 9.8 Tf [(cognition and executive functions to self-report of psychological distress in HD.)] TJ ET BT 26.250 628.136 Td /F4 12.0 Tf [(Methods)] TJ ET BT 26.250 608.181 Td /F4 9.8 Tf [(Participants)] TJ ET BT 26.250 588.777 Td /F1 9.8 Tf [(Participants were recruited from January 2012 to March 2013 from the Neurogenetics Clinic, Danish Dementia Research )] TJ ET BT 26.250 576.872 Td /F1 9.8 Tf [(Centre, Rigshospitalet. Fifty HD patients with a CAG repeat ?39, a Unified Huntingtons Disease Rating Scale-99 total motor )] TJ ET BT 26.250 564.967 Td /F1 9.8 Tf [(score \(UHDRS-TMS\) of >5)] TJ ET 0.267 0.267 0.267 rg BT 142.451 566.474 Td /F4 8.7 Tf [(19)] TJ ET 0.271 0.267 0.267 rg BT 152.088 564.967 Td /F1 9.8 Tf [(, a Mini-Mental State Examination \(MMSE\) score ? 24, and a Montreal Cognitive Assessment )] TJ ET BT 26.250 553.062 Td /F1 9.8 Tf [(\(MoCA\))] TJ ET 0.267 0.267 0.267 rg BT 59.829 554.570 Td /F4 8.7 Tf [(20)] TJ ET 0.271 0.267 0.267 rg BT 69.466 553.062 Td /F1 9.8 Tf [( score ? 20 were included in the study. Exclusion criteria were other neurological illness, ongoing alcohol or drug )] TJ ET BT 26.250 541.158 Td /F1 9.8 Tf [(abuse and having a native language other than Danish. Table 1 shows the background information for the HD patients. All )] TJ ET BT 26.250 529.253 Td /F1 9.8 Tf [(patients had gone through genetic counseling and had been informed of their genetic status prior to \(and independently from\) )] TJ ET BT 26.250 517.348 Td /F1 9.8 Tf [(study enrolment. We have previously published results from the same cohort)] TJ ET 0.267 0.267 0.267 rg BT 356.795 518.855 Td /F4 8.7 Tf [(2)] TJ ET 0.271 0.267 0.267 rg BT 361.613 521.236 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 364.023 518.855 Td /F4 8.7 Tf [(4)] TJ ET 0.271 0.267 0.267 rg BT 368.841 521.236 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 371.251 518.855 Td /F4 8.7 Tf [(5)] TJ ET 0.271 0.267 0.267 rg BT 376.069 521.236 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 378.479 518.855 Td /F4 8.7 Tf [(21)] TJ ET 0.271 0.267 0.267 rg BT 388.116 517.348 Td /F1 9.8 Tf [( also including premanifest HD carriers, but )] TJ ET BT 26.250 505.443 Td /F1 9.8 Tf [(since we found no impairments in social cognitive functions in our premanifest subjects we did not include them in the present )] TJ ET BT 26.250 493.539 Td /F1 9.8 Tf [(study.)] TJ ET 0.965 0.965 0.965 rg 26.250 187.921 555.000 295.736 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 483.658 m 581.250 483.658 l 581.250 482.908 l 26.250 482.908 l f 26.250 187.921 m 581.250 187.921 l 581.250 188.671 l 26.250 188.671 l f q 450.000 0 0 247.500 35.250 226.408 cm /I3 Do Q q 35.250 199.171 537.000 21.236 re W n 0.271 0.267 0.267 rg BT 35.250 209.419 Td /F4 9.8 Tf [(Table 1.)] TJ ET BT 71.559 209.419 Td /F1 9.8 Tf [( Background information. Results shown as median \(range\))] TJ ET Q BT 26.250 170.898 Td /F4 9.8 Tf [(Procedure)] TJ ET BT 26.250 151.493 Td /F1 9.8 Tf [(The study was approved by the Ethics Committee of the Capital Region of Denmark\(H2-2011-085\), and written informed )] TJ ET BT 26.250 139.588 Td /F1 9.8 Tf [(consent was obtained from each participant before enrollment. All participants had a minimum of two planned visits. At one visit )] TJ ET BT 26.250 127.683 Td /F1 9.8 Tf [(psychiatric screening and neurological examinations were performed. At the other visit neuropsychological testing was )] TJ ET BT 26.250 115.779 Td /F1 9.8 Tf [(performed. The same physician and the same neuropsychologist performed all examinations. The examination by the physician )] TJ ET BT 26.250 103.874 Td /F1 9.8 Tf [(and the examination by the neuropsychologist were performed blinded to one another.)] TJ ET BT 26.250 84.469 Td /F4 9.8 Tf [(Neuropsychological Testing)] TJ ET BT 26.250 65.064 Td /F1 9.8 Tf [(All participants were tested with an extensive three-hour battery of neuropsychological tests, including tests of attention, )] TJ ET BT 26.250 53.160 Td /F1 9.8 Tf [(memory, visuospatial functions, executive functions and social cognition. For this study only tests of executive functions and )] TJ ET BT 26.250 41.255 Td /F1 9.8 Tf [(tests of social cognition are included. The tests were administered in a fixed order. The education index score \(range 8-17\) was )] TJ ET Q q 450.000 0 0 247.500 35.250 226.408 cm /I3 Do Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(2)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Huntington Disease)] TJ ET Q endstream endobj 190 0 obj << /Type /Annot /Subtype /Link /A 191 0 R /Border [0 0 0] /H /I /Rect [ 142.4505 565.6727 152.0878 574.4910 ] >> endobj 191 0 obj << /Type /Action >> endobj 192 0 obj << /Type /Annot /Subtype /Link /A 193 0 R /Border [0 0 0] /H /I /Rect [ 59.8290 553.7679 69.4663 562.5862 ] >> endobj 193 0 obj << /Type /Action >> endobj 194 0 obj << /Type /Annot /Subtype /Link /A 195 0 R /Border [0 0 0] /H /I /Rect [ 356.7945 518.0537 361.6132 526.8720 ] >> endobj 195 0 obj << /Type /Action >> endobj 196 0 obj << /Type /Annot /Subtype /Link /A 197 0 R /Border [0 0 0] /H /I /Rect [ 364.0225 518.0537 368.8412 526.8720 ] >> endobj 197 0 obj << /Type /Action >> endobj 198 0 obj << /Type /Annot /Subtype /Link /A 199 0 R /Border [0 0 0] /H /I /Rect [ 371.2505 518.0537 376.0692 526.8720 ] >> endobj 199 0 obj << /Type /Action >> endobj 200 0 obj << /Type /Annot /Subtype /Link /A 201 0 R /Border [0 0 0] /H /I /Rect [ 378.4785 518.0537 388.1158 526.8720 ] >> endobj 201 0 obj << /Type /Action >> endobj 202 0 obj << /Type /Annot /Subtype /Link /A 203 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 226.4078 485.2500 473.9078 ] >> endobj 203 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/files/2016/11/Table-1-HD-0003.jpg) >> endobj 204 0 obj << /Type /XObject /Subtype /Image /Width 600 /Height 330 /ColorSpace /DeviceRGB /Filter /DCTDecode /BitsPerComponent 8 /Length 35811>> stream JFIF``;CREATOR: gd-jpeg v1.0 (using IJG JPEG v80), quality = 82 C    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$JX" }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?#ZmA=yu<?;=k5sXlB* K0=HjlSfVwϞPٜ܌0I 3S\? ^O"w-znmsPC⺹ۛeX`33Ս7 ϨA Q )ֲMcs!\d$U ]? ^O#?.xYGAx-tۍ=.t|…+xڲcjo5ׯmXDnbIgrhl\? ^Ns-zⴻKvmwGԙy#y⻯>PeDeyvvP>LW"?3M>Oqs2}lwdr {WEhjOP}BKZy 92˵4Bk s5{sF4ۋCN)-11w!Rdڣ_IE ͣE%O H%N29K-%Y,XI99U .o$qQb#!SV /SIEH7[2w$[b B@8}=ׇuC6RHiUY7v>Mc @nG ; -~U>s7<-߅4FQF6CDz@b^Mm@\h !LңcnUE9iio]Wlk!ebN JiᛄI,Z[ slp=YAgAopHPtq\{x]kWW~۵V>DbFPQ~Y}iOĸׯrof IR`}H9=Ar K*$PGB#?c N >4-?JQ\&EZ((((((((((((((((((c`KuN%((((((((((4Phts]Er??׎k@o:Lj5/mS y|rp~R{/&w#K S%~q$Wa1Ih#7}2u5,$<-VSssZfADi-BJLIb޹ڴo/YX` HT }~?$^@8SW~Mv1:X ׿ J[z[|ܰp6: zVi4-?JQ\&EZ((((((((((((((((((c`[uN%((((((((((4Phts]Er??׎k(( Ώ^i[^ppֹ]_Ǧ^M7H"UH Uq9w5^L|/p*ɵQ3>, Z_4+OK Zj[NibD*#}ROTK[V@3T +c`KtQERf (&@ih(((((4(~%;Q\%Ŀ;(((/hZsC5q\Y-&*#ҷM7`q7ø;u7}f\qG?Ixg\O]/Jb6r,W?q2zW]Rc΀8 >LB ]MH6w L5һ_8 a8w1&(iǎZ)- ( N[$Ÿ+]Er xS%k(((((((((((((((((Z6wKs-e+C "sOҝ'-fŖO%fZ ڴnc.|PT,Ž <Jiۯnx5 I4XA[kZ,RYfH Wo$jQuq"ľ4M~UA]Z'!m ԣH2 [bxY x_3MtP/Ok)h'75@<}A I>߅S?$QG@<}A I>߅S?$Qj8_>ׅS?$o3xcgqH@4-l:pO;1L6>#sd/&JNw5`P/Oo)h'75`Q _3Md/&J('55k>&mu*[qa,m1eH]yID4d&o%X4PE/4}@?ھ(9g?ycv]i=Onxfg3ic#za4krxDB o)|c`*:ϋo-Z9.RM'WFd.ۀ%./ !ڗg m=zՎLɭ]JzqP>\K3~R`\#+i "] 3Z:\er#B<}A I'55bP/Oo)h'75cڏ€9x^LM6=~϶?$Ui,ᧅ3@OW/I?iV(((((((((((((((((A-/}J)4W"8?Y5hIq%6?> > x3Ž!!Đ8Ucלސ,ףR ?q?TvekzdZNX d.WÚgzb., [ g88&#S\wRGHR6###5F?+цx?ƫk>(׮"Olw0ϒp1 Z]A,#v73V|%dI`>֤I$NsNj:ԯu(Q5,߇!W8E;TNсOz↉}jV( n|x[֣٭c*[Nn< X0z_?kѿ)?Ɨ?lѿ)?ƫMմ)Jnnm!o"0bsk }+N!\hx#h4o O񮢊c9ZF?hx#k9oZF_ZF(_?lѿ)?ƏZF(_?lѿ)?ƏZF(_?lѿ)?ƐOQ+яZu4UQ +mɭie{d<OIV~>Mj7^L-$-AdS|cig ףR;Scլf:V>es aI&~S Ŷ/溼ޤur<CfI4<CfI5Q@_?lѿ)?Ƙ~'+vGb??ƺN|-ᧅ1"E-u-iOZ蕮 ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( (9[)_UCë6Z-#t[0\Wm[pa_o#iګiEip Ӛ K3Zé$,!X419r$78٤up魫j#ZM"yM:ycv23һ=B٧{0-w;9;YFrZOI;͍C e HlgѵѼKu SiLruoypzSB-ZW|Msi; - <-ޕj'0XrXFqcA_-mCUf.A'͑;pI/L!'WVMKe⩭J(yaK#`p$s+bcO1uy8Q̇ 8|njL?pc58~tqXW\CBk2Y5XzIc%݌euɅ0[U$/5ou=(d(Ep"du954$wc8,UGeeR\ pDx#vB]'Vqb@NW_ h #OP~?4/i)bށWkj杚-"E&h-ȠLё@ E&G4dzIA`:4(~%;Q\s ćts]F}hϽ.hZi-s%20i`:A\oZMey sN%WSk+PQ"[[)u ~4[Y q{4~yn.&3ĦW#b!}q'>bxlfD[I^Hp̽ZVz-6+{@(s+i]&[T!7w(R *H5={^Э5x֍b.o&;Iv8$2X{YcM67^K-^ 'oUc{dZx[G4tfdkxJ})ѕޝwM:żK#v$"J8q|T4;_T]7$[e*#î>WwzKXo- :ZsZZYϤImdsoF6}xb?~mVuYh ~@Dsl94~'\]d(",I;0րE&is@'z3HXs? xS%k_oO "DuQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQExkKN]=ȹ/p|zm5bmWV0/b Oq2 Jq+m;[IaWWN#@3F4 (?Kw%rxEcP L]T%q :P񭝻7-nyeeT\M#oeiquyݙRsjVW:߆~/3R(e6Mȗ  &@v6 ԰A:]і1 g$ q|`5$ k oϼR,k^M,Kmd_@DoF+.9{ }.[^M,#2UO, b.x }<1'h?]:J(s}^4nxyx_Oѻ&(?H=#/ h3[^  c7Vfq:CcL(9l55ōσRA ]AF@IixP[7q3}Q5 "Lmm-JfH`B?t!wFO ߃.<y,[,iXrmP@ `A7Km Ox&ʑ伕B?I#֭Cƪa |&~"og9⹴4 z0M2;BH 壸̒9=qOqmow;,"Iv: 5/sy'Lnk'$j |C-q!% )=6`ڦ65ĺzs%j6X#,l P KpsvҒƤq 6F(Zv.(R *%c=p O&/C4YkZ]_W~@qK~k_q|O~vS'"$ۚj =o@|HGi3)$~Ҵ}FLuٴd)YdH'0ֺ_iJo|N6I5f1 GG?]h(?@Ο4fWZ? =C GGFks??tGz4fWZ? =C GGEstGzΏ?'P摛n2:3 GG?]h?&s Ąώ+ti/ۛŔ|K#N8MtGz4c֏?(PºQ~:zi\ku??E'4hՙPI'ĚN*@ bO=:Mot֋ xZV^wv ~c7<;z$ZW-̊cWᑑNAS$=m$Bb;Ss9Z釆1}I4dx⡾/v -=9SÚoLV8RX|E}'mϛNH<('IjAAϽy-|7fO]XR8Ox$\zXiZ$ZoVFh=}k`ROi;?kZ滹Et`"$KѼ=j|am9[L"$rsAr+s֏?'P3Fks??tGzgOMgcºQ~WZ>QzM<)`OW/cៅ?iV(((((((((((((((((?GQH[\u{R{ymn&1 c/!dSӑT4Z{+h*i:ַ' OQ^OZes K(&~f> =K?|fV}j8&+¯cp6ߓv/z?(sR5,Lo~ S`A4_]h)\֡XxW-Kd?kiDmxc| I?)?Ɛcz_'xsosCME%w_+XZ=3IؒY%hp;Iʅ s^ Ğ֮4 G>O)92edcG#ҥ?Ml#\y O=&J?sO26^0deÌ.3Oj]zd.U{|YflFI}íVFđE65,~!0|=☙$H$Ҽ4ue6H+nOO|TN%΃m}GW,jYrL]Hu ZM<lx;TSh~'XB-f#jn.Pn5&K|9;:}OvIw*[ I#bGd׼.'LxVCiFw#m8XSl1]z_C/x溊[@?J(/]z_Gh?ZJ,u 3-,uRE_nՇRCբqowOm4PGf O&0R#{տxNEsVK.m&HyLE4-rX_xVח]z,r\&09L,^ңֲ4 ͻ&2c05$ti!:׉u\-H.$GpֆK<.r3GWJ-MaA( b=0FO]ǃo iN-(dh۵rz׵.l .mh:x IfĴoPUcVԮOxui+$fT /w'|;k귗̖.V31Tө&bG//w'>x_Uu4P3;T} (_^?O?%SZg]^G7>:Y,|m*b3q >lNr8;ThPK^:w󹮢9x<GؼA J卟;U x ..|EXaK@IW9oV魄e-)\sIx^{'^ &LN3:{:oji}xWvdS:> ҸI=CFk7Q y5G6o~xNS7]KusKeqsɥ3yl L ˟60uuDIc Xbn>ա,/($>HYRm.`3}Ч\ְ{kOTQ\qsi$i}nQXf3Đ~[ >tGcq!A Ђ_>(.vn#YntcRǐ2nQG]#f/x%HX1dXZi7wvVwm]=-QVle#hZ=އ ڔ0[YNsgo洗䃸\Ƞ]źeKTKy#?w''I7gZתRm_1%ni15 ,9<GؼA Jrb|/y*^>:?O?%WUIހ9iLȴK]Er xS%k(((((((((((((((((JeO|НcM?5'Y(ږa|!I6Jii ]}/]c\"!saR￶4Z?4ZחJ4zw,PG%f,Ł' X zf+ocN% H&)=_}7Ɣkh_#6Z| wj2.>A:֧Ν{/4Q6n?xA,Uz li4li5#m:_K>K*i^DF1UtSrx A%XxCO죸1BzR?o-?oO O\I᭭Z}E~RCL~o/I8ڦtO fxkb`"6 o 8k4o-?x/#6 o icݬʉTO7o5ݧM;PM5wH `wc@4Z?4Zoltֺ{On`2JUe^*xt Ŭ6XnI@c3ҐƛA OIBƹ'>ЭKbK\Vxb;5M[{KOӼe$9!!AҚֿ4Z?4Z]G᎛oz@gݮ IrC>^ 0*O8榷[bvdr  ۱p;7Ə}7ƼxVþ./Iu DHV,;t=m.xY&YfK-3|2€83I1\/}7?4cM-?qg>8 $̪t|py|>vjX RP1ow V>jgto-?p| ϫ6r;Tìw'8>,.KMMZ:4ÖA ݈qvi_cM_6 .6cm]A|IX ![s<+dGu94f2RʻC{Y4ZO7ƹ-&4}1/b*N2 : G_zu 3f+}=6aB/_M 3mk-n5xByokt.0A<Ү? nl-[)tA*۔f@w`nRG#֘f$X^CRd1tBz e4Z-;oa^j +$ ifC/\4Bo i0O+<EkGV8Rom_uA77D~<rp: ~U%O9#9%*$U'+TxBmY4z~ y2lf7ϛTW5 ǩ4*ҳ99E q֦}K +!! M7c8 +~@-'*p @^LJ[kIKYc TbҀ7I4\/ Ž]5 pI>^3nhͶèY)W KӚO9dzs u,KpŻ~DBQ=+*ͱ{jE.^y$fwgЮzG;&seKi7B.<'i)MbŗzDQ oskhl):\ ߭Yx["iʗ4l5c0 Ԑj][SwA}i<+zHi3 =EƏCqmioZR23=i|DkFhd8h'oB=E4UFz7-2qI}g "U1aq)ӬχT֎-NL ~fwg"=zPN:_hB5L('z=MK{teRvU/^FFF:HKָO_{y]GmaC!e|V@Tv?Z/o [i2j.m6ym"e x%f[+hoYZj7vKK$ lw>2G-5*NIVZBnoP­ӆ,*2FEuXXY[w3u gyЩQ$ 7Ù#S]7Qͣ?ٖ6v [6Fnx9A|kNAhGRX!nS3!g\ÿ:zdW&ά!T< <v[X&Vģ!8ǽmhl5KYu'k۩cu(" ݂zs+_2˨ZgZ$OXVXZ=s(SOąu-[Q} ?0+ @>x|1Yavv\"ш`HG x1‹yY\0j\|JẴ 3UK O F#]ʭo'tjmi-)wi{t p| #8P u -6mkjPA1d#9Fj Q՛Q!YVK)v"a勁N@37S eQ/6ƗdvMv#+U [SO$QX[i{n{42Q@;{p( >]i^>؏q\[T 2~7íbY>N˘4.3s$~i.'ˎ´tߊ|]/mnGi#t 8'}-%fEX #cGx#? 5kVůx&d$NBR(hA$zr|I̡K>R!R8tk]&Nh [X%١kYUxM#s[^5iumvV;'V5\,xZw>0Q{;͙I6 TH汵Z4k}2]X`/4bM0s xyI OH%Otm?Ok{NfX=[c1 [݁z<۝^ aO[qhOT9yPcӚIs7ߋHAcb$Qt.5XēQpG}!cC9YQQabJ[2"W_3jpSox] iq%TY\z/" flp!G rH2T[kqetճD\YK--T㏘<6eE&oKh> YO+<рGQ#M|j&w2FڄI8VhѡhfVpO9#FԮ4{d&4md Ib t8,5dQkLK !.q|͜S]'n_#]<9A"Zj;A575Ю4Ğ+;HZ<$m~T& Nܠ!9C=3NMBˈ R#'d$RLKEŭ&;1g#{=_[h,tH̄>ݠ2=}w:Ljum)[xldE[ >['wt뎕ʼni.`lNB ; n3GPEOx?V)伸{ >Ÿ"uWj0sGI.[ .[alO3wm\Ӽ3C-QKtu2; B6?%jOux|E=K|,];|mPq, NABUDW\=NmB)E(&s_3 gYt;-2X-5Ab}#qb Ѐ0) ^!î6,۴D7—Xro8sFqI>kڶY>"D%F_3`41t _u׀IMyS$F??uEhHm Wx$1iw:֦5]JtY( |O$s5.5k]BY&cWc$1! ڝMj8okL^6G oT) 8$3RY@u?6m\j_͠MX꺃JҠ"ơ$+;d :ٟmGS70& 1<(@'ީ{w}Zɣwysi G4B?4iػL "KWo JGu1>gA/_jmǧ5OW>(y╵)"QU[ L<m=L Ʒk5jK]?ؘE&؄Khe%P9, 5㴖FYl.l4yͻoAwNj}$>T|Ru `8$ dp 'խn-5 Z m4tD.3vN~ꯦ-^Jt:!"IMb7 , 1f80i#ΛIvoclhy~`EڤN?s15KM>,zt7xN>qwPE&i! ,REř}zYfL {=2r>/cuo=.et4L `.Jf4NhϠw 7VnدbX{Y[.zËajV"-3ؒ%3 1#滰0(Uu__j>4E46 EŁX2Z7M'N}3M{.^*y=M^REzW9/ .롬jzl y\)RXI@C\՜%oK;yaE/'H< aiBW,$R28;V*I$~] mGqw7GOBwDU%Ow OC1T_ S-kugkSsD%7͌>giь1wa-?tX`j].=/fZs%$ȑ|DFF&±g]GP'{=/hgUYX#qlcd瑇FsE1f,.ekx5MG*9n$gn?ʼnoo`k\ra,4a@dYx`:tƩvQt2#(c{vlm5XZ [ TIӒ8`AuX Ȫrұ_s]kIy-1%eV"m[d_ݾIYx A.JN;Q :wq3 =ִZ4jA̶nlUճa* zuՇM-ݖxǘ#"_ך\j$dqn:$P3d\\GOxM֟C䗆ݯdɂ=xr)!iEm;P--e,s:Ր` rt>#IkjE<?5$`NOSNyz_k˽B;}CA\M%@J;H&j2xz}6cI5)^cyeUN0p`h~[+ }k\2H-nK! $p kz$qEZc Mdt`؊OŻ4m|9ŷ`$uڑ*1*G J^}0JM5IeAܑ7#6 -30>m@]ڼ^mҳ tlAUR7`T-^'YI2öRq9Y#>jsϨEyA0r#:V~cAХ%u}GԲ-`~XwG$FhLm=<={0°$"GtoC$:.iqH,HP9[QZɪ=EݦI8UJ]yp:sԇDԥB4a|崑#*60ݜ`7s&iS$7\e!d<)?*EKBA2Vw18a|W5 Z 6m>1/͍ ȪFN{V.C؏'[.>F:r4CTKha !,wr)4O 꺎#%w 1<$SdwCmFI?rA%oHd8 w:`nl->ZjQ.KSUxVS/ݻݴzT);Hm[bn)#,u 8b}G[Bym5O7~C)\2Ed½2^xKFgx0i\m` &Ԙ`8:yk}gZ[L4jn YQ@F 666^YƱӳKrϽ9lv2qqHE1|_ m!x^8mƣh Ȏ7VK(q$/,p3L>z J-%dTai5s#3Z2>9۸] ~Nl b&ic'% >SBiŋHۧ3oP0}$?ѼOVk%đ#|ʧ~r4f*msV6KWI0 h\k&.{=b.HDv}H_#3鎵NĚjH* 3 嶙3KgZQ)BVcs.GS$V ét.ĞZF2jVuݵ a< U6=tB-&j8)3x"߉\at-=RInahC5'ŀf8a"a&M#It=;hlj4Yð WIivneUf!nHP@K橪jq!E |8J/kl;[jIc q YB l*ʒ J8en;Ynk(lr1x#l`Jo-ς!"؈yyُ|f\[gwO1m(VUR-3h?u9j&oMT.\T#δ|6[uDVތ UU? !yZm2{cKV)^ 1 6R4|OƯd@Х,ltkʐh~3[ĶKw}bbRQgJ w]Q(+bcy$HWs%XNKll>> % ޞ^|:6ӋYp2@ו]nF7xim? k{vw%)gm+߫noV yd;KAiqVDlG.;LgUCDVPie#mȋ"HWU`rOj'ͨ\_9L T[Kyy7wCuM[#5vzBߋY I$gkqב漾4m-<!bUXb͜39<ԁ֏1ƏTYpy~?J0*{?3dJs;FK`ajtWC=&63_G eR0 $85cῊQx=^Mɚѕ@^Ggvz5ψ\7W?'!cR&]At( W gpb0Nw_ o-mRo$w[clpnWIP1KUnuӲjv>(F17}To/I3ַ&GgT]:qҼq$0xKvaco|Id xRMO'u5TV$Θ#<,ư\2xUW`? HғevLQ0<ϔn V>rNft.Wl (viBxd;Q4v&ݥ:uepGp) |4ªl~tky +b`(LpLњ.I4QEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQE!k[%h'#/[==j\Nj<-/ӱumo\7kɔu`b}np~ : VvA-ۘIMFr# !QVQeq8c]6ӚaJy` 9$%#ī~؛@,vb 07HD}HI3K=W Ā@iMjX}7K͸^p#yG)cׁ :nk9o\\j6+`F&C|zNXFo&̢sr;ռk4~HVx]m`L'P6]$Mil* ӓӱu^=5)Eo^AkֳFk28yEQ#p?7$S/u"xD'7vtFY腣8)ifӁU5mZCkL0! HFcPIx-ky @)o{vv%m_,kkm{ ykI8 ;7}d9IuFvzҼYd]k3E\]Xl@!t!nNEWҵYxji2lyV+PJIU#y_jVu:r`8G5 r_^PKln7 %gpis}B{mF8ehbH0p(-E1u=_Pֆi2|:]6vF0 s\,|]3vx _IY8_κ. 8;S?tukkɰE\ĒLb RyM %y -RXe?ֳ5R9G=j/hMh\8f$d&)ky%ts,]th7"LF 8/'Ė- 0P]lRF]'& K RTI,Y)^e"0kp;W-ulXo# v0{X|u͠kGc%+#yv%A F2N;\iC0Khox<̑1]ٴhgh 1R}O|U/P-aoj]ުM۔e˝\%go9Uuk]&7X0?y~$Q +[{gkKtU`1" ыڒ1Z[jiw[2?1c܀9{~hIy|I.o_F)vd#7@큚_Aί^_nCٽl>IIZcB6I^]ak-̩ y$sEOs|9eomsqqe}Rbr@ nɏ0^ry٬BO R.tKP;w{FB;Ԃp8HN7]&co*9"ڀ7av Wv;g5ƻux [sh7;cLygZ J%ķ2I #8% Gr1ҝ+Y֬< J0$A$>ƸOŦD-\tǿ,5_N5톫☥mEIjĮ7۰zRa=1Jxlj.:2Kj-cV7COh>cÍǎ!>}}{%dggc#D|7n爌S)UyY @}I56ƥ\gՖhbI/o*VewaH'k5׌V]HOݹQmч"AqK@Š((((((((((((((((Tu4A@qS0J AKKړW.HhGQ4-;_ UBH _2kg۬)$($ORI'ڔQ@ zz6u%&[Pm5[9l"`aq=G#ڭP6ְYooJG TAiPmGQ@ݣҔ;R@f=8QL_Jud^> endobj 206 0 obj << /Type /Action >> endobj 207 0 obj << /Type /Annot /Subtype /Link /A 208 0 R /Border [0 0 0] /H /I /Rect [ 59.8290 553.7679 69.4663 562.5862 ] >> endobj 208 0 obj << /Type /Action >> endobj 209 0 obj << /Type /Annot /Subtype /Link /A 210 0 R /Border [0 0 0] /H /I /Rect [ 356.7945 518.0537 361.6132 526.8720 ] >> endobj 210 0 obj << /Type /Action >> endobj 211 0 obj << /Type /Annot /Subtype /Link /A 212 0 R /Border [0 0 0] /H /I /Rect [ 364.0225 518.0537 368.8412 526.8720 ] >> endobj 212 0 obj << /Type /Action >> endobj 213 0 obj << /Type /Annot /Subtype /Link /A 214 0 R /Border [0 0 0] /H /I /Rect [ 371.2505 518.0537 376.0692 526.8720 ] >> endobj 214 0 obj << /Type /Action >> endobj 215 0 obj << /Type /Annot /Subtype /Link /A 216 0 R /Border [0 0 0] /H /I /Rect [ 378.4785 518.0537 388.1158 526.8720 ] >> endobj 216 0 obj << /Type /Action >> endobj 217 0 obj << /Type /Annot /Subtype /Link /A 218 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 226.4078 485.2500 473.9078 ] >> endobj 218 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/files/2016/11/Table-1-HD-0003.jpg) >> endobj 219 0 obj << /Type /Annot /Subtype /Link /A 220 0 R /Border [0 0 0] /H /I /Rect [ 142.4505 565.6727 152.0878 574.4910 ] >> endobj 220 0 obj << /Type /Action >> endobj 221 0 obj << /Type /Annot /Subtype /Link /A 222 0 R /Border [0 0 0] /H /I /Rect [ 59.8290 553.7679 69.4663 562.5862 ] >> endobj 222 0 obj << /Type /Action >> endobj 223 0 obj << /Type /Annot /Subtype /Link /A 224 0 R /Border [0 0 0] /H /I /Rect [ 356.7945 518.0537 361.6132 526.8720 ] >> endobj 224 0 obj << /Type /Action >> endobj 225 0 obj << /Type /Annot /Subtype /Link /A 226 0 R /Border [0 0 0] /H /I /Rect [ 364.0225 518.0537 368.8412 526.8720 ] >> endobj 226 0 obj << /Type /Action >> endobj 227 0 obj << /Type /Annot /Subtype /Link /A 228 0 R /Border [0 0 0] /H /I /Rect [ 371.2505 518.0537 376.0692 526.8720 ] >> endobj 228 0 obj << /Type /Action >> endobj 229 0 obj << /Type /Annot /Subtype /Link /A 230 0 R /Border [0 0 0] /H /I /Rect [ 378.4785 518.0537 388.1158 526.8720 ] >> endobj 230 0 obj << /Type /Action >> endobj 231 0 obj << /Type /Annot /Subtype /Link /A 232 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 226.4078 485.2500 473.9078 ] >> endobj 232 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/files/2016/11/Table-1-HD-0003.jpg) >> endobj 233 0 obj << /Type /Page /Parent 3 0 R /Annots [ 235 0 R 237 0 R 239 0 R 241 0 R 243 0 R 245 0 R 247 0 R 249 0 R 251 0 R 253 0 R 255 0 R 257 0 R 259 0 R 261 0 R 263 0 R 265 0 R 267 0 R 269 0 R 271 0 R 273 0 R 275 0 R 277 0 R 279 0 R 281 0 R 283 0 R 285 0 R 287 0 R 289 0 R 291 0 R 293 0 R ] /Contents 234 0 R >> endobj 234 0 obj << /Length 30649 >> stream 0.271 0.267 0.267 rg q 15.000 23.429 577.500 753.571 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(calculated as the sum of years of schooling \(range 7-12\) and the level of post-secondary education stratified into groups \(range )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(1-5\) based on the method previously used by Mortensen and Gad.)] TJ ET 0.267 0.267 0.267 rg BT 312.939 757.079 Td /F4 8.7 Tf [(22)] TJ ET 0.271 0.267 0.267 rg BT 26.250 736.167 Td /F4 9.8 Tf [(Emotion Hexagon \(EH\))] TJ ET 0.267 0.267 0.267 rg BT 131.882 737.674 Td /F4 8.7 Tf [(23)] TJ ET 0.271 0.267 0.267 rg BT 141.519 736.167 Td /F1 9.8 Tf [(: This test consists of 30 cards with pictures of morphed facial expressions of the six basic emotions: )] TJ ET BT 26.250 724.262 Td /F1 9.8 Tf [(happiness, surprise, fear, sadness, anger and disgust. Each of the six emotions was represented with four pictures; each )] TJ ET BT 26.250 712.357 Td /F1 9.8 Tf [(picture was morphed with either 10% or 30% of the neighboring emotions \(e.g. happiness is morphed with either 10% or 30% )] TJ ET BT 26.250 700.452 Td /F1 9.8 Tf [(anger or surprise\). Between two neighboring emotions was a picture morphed with 50% of each emotion; these were not )] TJ ET BT 26.250 688.548 Td /F1 9.8 Tf [(counted in the total raw score. A card with the six emotion words was presented, and each of the six emotions was explained )] TJ ET BT 26.250 676.643 Td /F1 9.8 Tf [(before the pictures were shown to the participants and remained visible for them during the test. The pictures were shown in )] TJ ET BT 26.250 664.738 Td /F1 9.8 Tf [(random order, and the participants were asked to choose which of the six emotions best described the facial expression. The )] TJ ET BT 26.250 652.833 Td /F1 9.8 Tf [(pictures were shown only once, and no feedback was given. The test was scored as the total number of correct responses \(0-)] TJ ET BT 26.250 640.929 Td /F1 9.8 Tf [(24\).)] TJ ET BT 26.250 621.524 Td /F4 9.8 Tf [(Emotion Evaluation Task \(EET\))] TJ ET 0.267 0.267 0.267 rg BT 170.365 623.031 Td /F4 8.7 Tf [(24)] TJ ET 0.271 0.267 0.267 rg BT 180.002 621.524 Td /F1 9.8 Tf [(: The EET consists of 28 short videotaped vignettes \(15-60 seconds\) of actors interacting in )] TJ ET BT 26.250 609.619 Td /F1 9.8 Tf [(everyday situations. In some of the scenes there is one actor only, and in other scenes there are two \(the participant was then )] TJ ET BT 26.250 597.714 Td /F1 9.8 Tf [(told on whom to focus\). The participants were asked to choose whether the actor was displaying one of the six basic emotions: )] TJ ET BT 26.250 585.810 Td /F1 9.8 Tf [(happiness, surprise, sadness, anger, fear or disgust or no particular emotion \(neutral\). The EET does not exist in a Danish )] TJ ET BT 26.250 573.905 Td /F1 9.8 Tf [(version and therefore the video clips were shown without sound in order to exclude any influence of differences in English )] TJ ET BT 26.250 562.000 Td /F1 9.8 Tf [(language abilities. Each video was shown once, and no feedback was given. The test was scored as the total number of correct )] TJ ET BT 26.250 550.095 Td /F1 9.8 Tf [(responses \(0-28\).)] TJ ET BT 26.250 530.691 Td /F4 9.8 Tf [(Social Inference Minimal \(SI-M\))] TJ ET 0.267 0.267 0.267 rg BT 177.960 532.198 Td /F4 8.7 Tf [(24)] TJ ET 0.271 0.267 0.267 rg BT 187.597 534.579 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 190.007 532.198 Td /F4 8.7 Tf [(51)] TJ ET 0.271 0.267 0.267 rg BT 199.644 530.691 Td /F1 9.8 Tf [(: The SI-M \(Danish version: \(Bliksted, Fagerlund, Weed, Frith, & Videbech, 2014\) )] TJ ET BT 26.250 518.786 Td /F1 9.8 Tf [(consists of short \(15-53 seconds\) videotaped vignettes with professional actors interacting in everyday situations. The )] TJ ET BT 26.250 506.881 Td /F1 9.8 Tf [(exchanges are either sincere or sarcastic. The sarcastic vignettes are either with simple sarcasm, meaning that they are acted )] TJ ET BT 26.250 494.976 Td /F1 9.8 Tf [(in such a way as to imply the opposite meaning to what is actually being said, or with paradoxical sarcasm meaning that the )] TJ ET BT 26.250 483.072 Td /F1 9.8 Tf [(exchange of words is meaningless unless one understands that one of the actors is being sarcastic. After each video, the )] TJ ET BT 26.250 471.167 Td /F1 9.8 Tf [(participant was asked four yes/no questions about the interaction. Correct answers to the questions for the sarcastic videos )] TJ ET BT 26.250 459.262 Td /F1 9.8 Tf [(required interpretation of paralinguistic cues such as tone of voice and non-verbal cues such as posture and facial expressions. )] TJ ET BT 26.250 447.357 Td /F1 9.8 Tf [(The test comprises part A2 and part B2. Part A2 consists of five videos of paradoxical sarcasm and ten vignettes that are either )] TJ ET BT 26.250 435.453 Td /F1 9.8 Tf [(sincere or with simple sarcasm. Part B2 consists of exactly the same dialogue as the ten sincere or simple sarcastic videos from )] TJ ET BT 26.250 423.548 Td /F1 9.8 Tf [(part A2 but with sincerity and sarcasm switched. For this study the participants were shown all 25 videos. Each video was )] TJ ET BT 26.250 411.643 Td /F1 9.8 Tf [(shown once, and no feedback was given. Total number of correct yes/no answers \(0-100\) was used in the present study.)] TJ ET BT 26.250 392.238 Td /F4 9.8 Tf [(Reading the Mind in the Eyes Test \(RME\))] TJ ET 0.267 0.267 0.267 rg BT 215.322 393.746 Td /F4 8.7 Tf [(25)] TJ ET 0.271 0.267 0.267 rg BT 224.959 392.238 Td /F1 9.8 Tf [(: The RME revised version consists of 36 photos of eyes expressing different )] TJ ET BT 26.250 380.334 Td /F1 9.8 Tf [(emotional states. The participants were given four choices of words and were asked to pick the word that best described what )] TJ ET BT 26.250 368.429 Td /F1 9.8 Tf [(the eyes expressed \(e.g., serious, ashamed, alarmed or bewildered\). In order to pick the correct emotion the participant needed )] TJ ET BT 26.250 356.524 Td /F1 9.8 Tf [(to be able to attribute mental states to others thereby using Theory of Mind \(ToM\). The participants were also given a list of )] TJ ET BT 26.250 344.619 Td /F1 9.8 Tf [(explanations of all the words in the test and were encouraged to look up the words if they felt uncertain of the meaning of a )] TJ ET BT 26.250 332.715 Td /F1 9.8 Tf [(word. The number of correct responses was recorded \(0-36\).)] TJ ET BT 26.250 313.310 Td /F4 9.8 Tf [(Semantic fluency)] TJ ET 0.267 0.267 0.267 rg BT 106.444 314.817 Td /F4 8.7 Tf [(26)] TJ ET 0.271 0.267 0.267 rg BT 116.081 313.310 Td /F1 9.8 Tf [(: The participants were asked to name as many different animals as they could think of within one minute. )] TJ ET BT 26.250 301.405 Td /F1 9.8 Tf [(It was emphasized that all types/categories of animals would be correct. Categories \(e.g., birds\) as well as specific animals )] TJ ET BT 26.250 289.500 Td /F1 9.8 Tf [(\(e.g., eagle\) were accepted. The number of different animals named was recorded.)] TJ ET BT 26.250 270.096 Td /F4 9.8 Tf [(Lexical fluency)] TJ ET 0.267 0.267 0.267 rg BT 96.157 271.603 Td /F4 8.7 Tf [(26)] TJ ET 0.271 0.267 0.267 rg BT 105.795 270.096 Td /F1 9.8 Tf [(: The participants were asked to produce as many words as possible within one minute beginning with each )] TJ ET BT 26.250 258.191 Td /F1 9.8 Tf [(of the letters F, A or S. It was emphasized that it could be all words in Danish except proper nouns. The number of different )] TJ ET BT 26.250 246.286 Td /F1 9.8 Tf [(words produced with F, A and S were recorded and added together for a total score.)] TJ ET BT 26.250 226.881 Td /F4 9.8 Tf [(Lexical alternating fluency)] TJ ET BT 148.710 226.881 Td /F1 9.8 Tf [(. This fluency test was developed by the researchers based on the most common first-letters in )] TJ ET BT 26.250 214.977 Td /F1 9.8 Tf [(Danish apart from S and F. The participants were asked to produce as many different words as possible within one minute, )] TJ ET BT 26.250 203.072 Td /F1 9.8 Tf [(alternating between words beginning with the letter K and words beginning with the letter B. It was emphasized that it could be )] TJ ET BT 26.250 191.167 Td /F1 9.8 Tf [(all types of words except proper nouns. The number of correct responses was recorded, and improper alternations were )] TJ ET BT 26.250 179.262 Td /F1 9.8 Tf [(counted as incorrect.)] TJ ET BT 26.250 159.858 Td /F4 9.8 Tf [(Semantic/lexical alternating fluency. )] TJ ET BT 196.943 159.858 Td /F1 9.8 Tf [(This fluency test was developed by the researchers based on a category that was )] TJ ET BT 26.250 147.953 Td /F1 9.8 Tf [(thought to be very broad and one of the most common first-letters in Danish apart from S, F, K and B. The participants were )] TJ ET BT 26.250 136.048 Td /F1 9.8 Tf [(asked to produce as many different words as possible within one minute alternating between types of food and words beginning )] TJ ET BT 26.250 124.143 Td /F1 9.8 Tf [(with the letter D. They were told that the former could be anything you can eat, and that the latter covered all words beginning )] TJ ET BT 26.250 112.239 Td /F1 9.8 Tf [(with the letter D except proper nouns. The number of correct responses was recorded; improper alternations were counted as )] TJ ET BT 26.250 100.334 Td /F1 9.8 Tf [(incorrect.)] TJ ET BT 26.250 80.929 Td /F4 9.8 Tf [(Trail Making Test B \(TMT B\))] TJ ET 0.267 0.267 0.267 rg BT 154.638 82.436 Td /F4 8.7 Tf [(27)] TJ ET 0.271 0.267 0.267 rg BT 164.275 80.929 Td /F1 9.8 Tf [(:The participants were asked to connect circles alternating between numbers in numeric order )] TJ ET BT 26.250 69.024 Td /F1 9.8 Tf [(and letters in alphabetical order. The time to completion was recorded.)] TJ ET BT 26.250 49.620 Td /F4 9.8 Tf [(Stroop interference test)] TJ ET 0.267 0.267 0.267 rg BT 136.230 51.127 Td /F4 8.7 Tf [(28)] TJ ET 0.271 0.267 0.267 rg BT 145.867 49.620 Td /F1 9.8 Tf [(: This 100-word version of the Stroop test consisted of a simple reading task and an interference )] TJ ET BT 26.250 37.715 Td /F1 9.8 Tf [(test. In the interference test the name of the color and the color of the ink did not correspond, for example the word blue could )] TJ ET Q q 15.000 23.429 577.500 753.571 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(calculated as the sum of years of schooling \(range 7-12\) and the level of post-secondary education stratified into groups \(range )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(1-5\) based on the method previously used by Mortensen and Gad.)] TJ ET 0.267 0.267 0.267 rg BT 312.939 757.079 Td /F4 8.7 Tf [(22)] TJ ET 0.271 0.267 0.267 rg BT 26.250 736.167 Td /F4 9.8 Tf [(Emotion Hexagon \(EH\))] TJ ET 0.267 0.267 0.267 rg BT 131.882 737.674 Td /F4 8.7 Tf [(23)] TJ ET 0.271 0.267 0.267 rg BT 141.519 736.167 Td /F1 9.8 Tf [(: This test consists of 30 cards with pictures of morphed facial expressions of the six basic emotions: )] TJ ET BT 26.250 724.262 Td /F1 9.8 Tf [(happiness, surprise, fear, sadness, anger and disgust. Each of the six emotions was represented with four pictures; each )] TJ ET BT 26.250 712.357 Td /F1 9.8 Tf [(picture was morphed with either 10% or 30% of the neighboring emotions \(e.g. happiness is morphed with either 10% or 30% )] TJ ET BT 26.250 700.452 Td /F1 9.8 Tf [(anger or surprise\). Between two neighboring emotions was a picture morphed with 50% of each emotion; these were not )] TJ ET BT 26.250 688.548 Td /F1 9.8 Tf [(counted in the total raw score. A card with the six emotion words was presented, and each of the six emotions was explained )] TJ ET BT 26.250 676.643 Td /F1 9.8 Tf [(before the pictures were shown to the participants and remained visible for them during the test. The pictures were shown in )] TJ ET BT 26.250 664.738 Td /F1 9.8 Tf [(random order, and the participants were asked to choose which of the six emotions best described the facial expression. The )] TJ ET BT 26.250 652.833 Td /F1 9.8 Tf [(pictures were shown only once, and no feedback was given. The test was scored as the total number of correct responses \(0-)] TJ ET BT 26.250 640.929 Td /F1 9.8 Tf [(24\).)] TJ ET BT 26.250 621.524 Td /F4 9.8 Tf [(Emotion Evaluation Task \(EET\))] TJ ET 0.267 0.267 0.267 rg BT 170.365 623.031 Td /F4 8.7 Tf [(24)] TJ ET 0.271 0.267 0.267 rg BT 180.002 621.524 Td /F1 9.8 Tf [(: The EET consists of 28 short videotaped vignettes \(15-60 seconds\) of actors interacting in )] TJ ET BT 26.250 609.619 Td /F1 9.8 Tf [(everyday situations. In some of the scenes there is one actor only, and in other scenes there are two \(the participant was then )] TJ ET BT 26.250 597.714 Td /F1 9.8 Tf [(told on whom to focus\). The participants were asked to choose whether the actor was displaying one of the six basic emotions: )] TJ ET BT 26.250 585.810 Td /F1 9.8 Tf [(happiness, surprise, sadness, anger, fear or disgust or no particular emotion \(neutral\). The EET does not exist in a Danish )] TJ ET BT 26.250 573.905 Td /F1 9.8 Tf [(version and therefore the video clips were shown without sound in order to exclude any influence of differences in English )] TJ ET BT 26.250 562.000 Td /F1 9.8 Tf [(language abilities. Each video was shown once, and no feedback was given. The test was scored as the total number of correct )] TJ ET BT 26.250 550.095 Td /F1 9.8 Tf [(responses \(0-28\).)] TJ ET BT 26.250 530.691 Td /F4 9.8 Tf [(Social Inference Minimal \(SI-M\))] TJ ET 0.267 0.267 0.267 rg BT 177.960 532.198 Td /F4 8.7 Tf [(24)] TJ ET 0.271 0.267 0.267 rg BT 187.597 534.579 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 190.007 532.198 Td /F4 8.7 Tf [(51)] TJ ET 0.271 0.267 0.267 rg BT 199.644 530.691 Td /F1 9.8 Tf [(: The SI-M \(Danish version: \(Bliksted, Fagerlund, Weed, Frith, & Videbech, 2014\) )] TJ ET BT 26.250 518.786 Td /F1 9.8 Tf [(consists of short \(15-53 seconds\) videotaped vignettes with professional actors interacting in everyday situations. The )] TJ ET BT 26.250 506.881 Td /F1 9.8 Tf [(exchanges are either sincere or sarcastic. The sarcastic vignettes are either with simple sarcasm, meaning that they are acted )] TJ ET BT 26.250 494.976 Td /F1 9.8 Tf [(in such a way as to imply the opposite meaning to what is actually being said, or with paradoxical sarcasm meaning that the )] TJ ET BT 26.250 483.072 Td /F1 9.8 Tf [(exchange of words is meaningless unless one understands that one of the actors is being sarcastic. After each video, the )] TJ ET BT 26.250 471.167 Td /F1 9.8 Tf [(participant was asked four yes/no questions about the interaction. Correct answers to the questions for the sarcastic videos )] TJ ET BT 26.250 459.262 Td /F1 9.8 Tf [(required interpretation of paralinguistic cues such as tone of voice and non-verbal cues such as posture and facial expressions. )] TJ ET BT 26.250 447.357 Td /F1 9.8 Tf [(The test comprises part A2 and part B2. Part A2 consists of five videos of paradoxical sarcasm and ten vignettes that are either )] TJ ET BT 26.250 435.453 Td /F1 9.8 Tf [(sincere or with simple sarcasm. Part B2 consists of exactly the same dialogue as the ten sincere or simple sarcastic videos from )] TJ ET BT 26.250 423.548 Td /F1 9.8 Tf [(part A2 but with sincerity and sarcasm switched. For this study the participants were shown all 25 videos. Each video was )] TJ ET BT 26.250 411.643 Td /F1 9.8 Tf [(shown once, and no feedback was given. Total number of correct yes/no answers \(0-100\) was used in the present study.)] TJ ET BT 26.250 392.238 Td /F4 9.8 Tf [(Reading the Mind in the Eyes Test \(RME\))] TJ ET 0.267 0.267 0.267 rg BT 215.322 393.746 Td /F4 8.7 Tf [(25)] TJ ET 0.271 0.267 0.267 rg BT 224.959 392.238 Td /F1 9.8 Tf [(: The RME revised version consists of 36 photos of eyes expressing different )] TJ ET BT 26.250 380.334 Td /F1 9.8 Tf [(emotional states. The participants were given four choices of words and were asked to pick the word that best described what )] TJ ET BT 26.250 368.429 Td /F1 9.8 Tf [(the eyes expressed \(e.g., serious, ashamed, alarmed or bewildered\). In order to pick the correct emotion the participant needed )] TJ ET BT 26.250 356.524 Td /F1 9.8 Tf [(to be able to attribute mental states to others thereby using Theory of Mind \(ToM\). The participants were also given a list of )] TJ ET BT 26.250 344.619 Td /F1 9.8 Tf [(explanations of all the words in the test and were encouraged to look up the words if they felt uncertain of the meaning of a )] TJ ET BT 26.250 332.715 Td /F1 9.8 Tf [(word. The number of correct responses was recorded \(0-36\).)] TJ ET BT 26.250 313.310 Td /F4 9.8 Tf [(Semantic fluency)] TJ ET 0.267 0.267 0.267 rg BT 106.444 314.817 Td /F4 8.7 Tf [(26)] TJ ET 0.271 0.267 0.267 rg BT 116.081 313.310 Td /F1 9.8 Tf [(: The participants were asked to name as many different animals as they could think of within one minute. )] TJ ET BT 26.250 301.405 Td /F1 9.8 Tf [(It was emphasized that all types/categories of animals would be correct. Categories \(e.g., birds\) as well as specific animals )] TJ ET BT 26.250 289.500 Td /F1 9.8 Tf [(\(e.g., eagle\) were accepted. The number of different animals named was recorded.)] TJ ET BT 26.250 270.096 Td /F4 9.8 Tf [(Lexical fluency)] TJ ET 0.267 0.267 0.267 rg BT 96.157 271.603 Td /F4 8.7 Tf [(26)] TJ ET 0.271 0.267 0.267 rg BT 105.795 270.096 Td /F1 9.8 Tf [(: The participants were asked to produce as many words as possible within one minute beginning with each )] TJ ET BT 26.250 258.191 Td /F1 9.8 Tf [(of the letters F, A or S. It was emphasized that it could be all words in Danish except proper nouns. The number of different )] TJ ET BT 26.250 246.286 Td /F1 9.8 Tf [(words produced with F, A and S were recorded and added together for a total score.)] TJ ET BT 26.250 226.881 Td /F4 9.8 Tf [(Lexical alternating fluency)] TJ ET BT 148.710 226.881 Td /F1 9.8 Tf [(. This fluency test was developed by the researchers based on the most common first-letters in )] TJ ET BT 26.250 214.977 Td /F1 9.8 Tf [(Danish apart from S and F. The participants were asked to produce as many different words as possible within one minute, )] TJ ET BT 26.250 203.072 Td /F1 9.8 Tf [(alternating between words beginning with the letter K and words beginning with the letter B. It was emphasized that it could be )] TJ ET BT 26.250 191.167 Td /F1 9.8 Tf [(all types of words except proper nouns. The number of correct responses was recorded, and improper alternations were )] TJ ET BT 26.250 179.262 Td /F1 9.8 Tf [(counted as incorrect.)] TJ ET BT 26.250 159.858 Td /F4 9.8 Tf [(Semantic/lexical alternating fluency. )] TJ ET BT 196.943 159.858 Td /F1 9.8 Tf [(This fluency test was developed by the researchers based on a category that was )] TJ ET BT 26.250 147.953 Td /F1 9.8 Tf [(thought to be very broad and one of the most common first-letters in Danish apart from S, F, K and B. The participants were )] TJ ET BT 26.250 136.048 Td /F1 9.8 Tf [(asked to produce as many different words as possible within one minute alternating between types of food and words beginning )] TJ ET BT 26.250 124.143 Td /F1 9.8 Tf [(with the letter D. They were told that the former could be anything you can eat, and that the latter covered all words beginning )] TJ ET BT 26.250 112.239 Td /F1 9.8 Tf [(with the letter D except proper nouns. The number of correct responses was recorded; improper alternations were counted as )] TJ ET BT 26.250 100.334 Td /F1 9.8 Tf [(incorrect.)] TJ ET BT 26.250 80.929 Td /F4 9.8 Tf [(Trail Making Test B \(TMT B\))] TJ ET 0.267 0.267 0.267 rg BT 154.638 82.436 Td /F4 8.7 Tf [(27)] TJ ET 0.271 0.267 0.267 rg BT 164.275 80.929 Td /F1 9.8 Tf [(:The participants were asked to connect circles alternating between numbers in numeric order )] TJ ET BT 26.250 69.024 Td /F1 9.8 Tf [(and letters in alphabetical order. The time to completion was recorded.)] TJ ET BT 26.250 49.620 Td /F4 9.8 Tf [(Stroop interference test)] TJ ET 0.267 0.267 0.267 rg BT 136.230 51.127 Td /F4 8.7 Tf [(28)] TJ ET 0.271 0.267 0.267 rg BT 145.867 49.620 Td /F1 9.8 Tf [(: This 100-word version of the Stroop test consisted of a simple reading task and an interference )] TJ ET BT 26.250 37.715 Td /F1 9.8 Tf [(test. In the interference test the name of the color and the color of the ink did not correspond, for example the word blue could )] TJ ET Q q 15.000 23.429 577.500 753.571 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(calculated as the sum of years of schooling \(range 7-12\) and the level of post-secondary education stratified into groups \(range )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(1-5\) based on the method previously used by Mortensen and Gad.)] TJ ET 0.267 0.267 0.267 rg BT 312.939 757.079 Td /F4 8.7 Tf [(22)] TJ ET 0.271 0.267 0.267 rg BT 26.250 736.167 Td /F4 9.8 Tf [(Emotion Hexagon \(EH\))] TJ ET 0.267 0.267 0.267 rg BT 131.882 737.674 Td /F4 8.7 Tf [(23)] TJ ET 0.271 0.267 0.267 rg BT 141.519 736.167 Td /F1 9.8 Tf [(: This test consists of 30 cards with pictures of morphed facial expressions of the six basic emotions: )] TJ ET BT 26.250 724.262 Td /F1 9.8 Tf [(happiness, surprise, fear, sadness, anger and disgust. Each of the six emotions was represented with four pictures; each )] TJ ET BT 26.250 712.357 Td /F1 9.8 Tf [(picture was morphed with either 10% or 30% of the neighboring emotions \(e.g. happiness is morphed with either 10% or 30% )] TJ ET BT 26.250 700.452 Td /F1 9.8 Tf [(anger or surprise\). Between two neighboring emotions was a picture morphed with 50% of each emotion; these were not )] TJ ET BT 26.250 688.548 Td /F1 9.8 Tf [(counted in the total raw score. A card with the six emotion words was presented, and each of the six emotions was explained )] TJ ET BT 26.250 676.643 Td /F1 9.8 Tf [(before the pictures were shown to the participants and remained visible for them during the test. The pictures were shown in )] TJ ET BT 26.250 664.738 Td /F1 9.8 Tf [(random order, and the participants were asked to choose which of the six emotions best described the facial expression. The )] TJ ET BT 26.250 652.833 Td /F1 9.8 Tf [(pictures were shown only once, and no feedback was given. The test was scored as the total number of correct responses \(0-)] TJ ET BT 26.250 640.929 Td /F1 9.8 Tf [(24\).)] TJ ET BT 26.250 621.524 Td /F4 9.8 Tf [(Emotion Evaluation Task \(EET\))] TJ ET 0.267 0.267 0.267 rg BT 170.365 623.031 Td /F4 8.7 Tf [(24)] TJ ET 0.271 0.267 0.267 rg BT 180.002 621.524 Td /F1 9.8 Tf [(: The EET consists of 28 short videotaped vignettes \(15-60 seconds\) of actors interacting in )] TJ ET BT 26.250 609.619 Td /F1 9.8 Tf [(everyday situations. In some of the scenes there is one actor only, and in other scenes there are two \(the participant was then )] TJ ET BT 26.250 597.714 Td /F1 9.8 Tf [(told on whom to focus\). The participants were asked to choose whether the actor was displaying one of the six basic emotions: )] TJ ET BT 26.250 585.810 Td /F1 9.8 Tf [(happiness, surprise, sadness, anger, fear or disgust or no particular emotion \(neutral\). The EET does not exist in a Danish )] TJ ET BT 26.250 573.905 Td /F1 9.8 Tf [(version and therefore the video clips were shown without sound in order to exclude any influence of differences in English )] TJ ET BT 26.250 562.000 Td /F1 9.8 Tf [(language abilities. Each video was shown once, and no feedback was given. The test was scored as the total number of correct )] TJ ET BT 26.250 550.095 Td /F1 9.8 Tf [(responses \(0-28\).)] TJ ET BT 26.250 530.691 Td /F4 9.8 Tf [(Social Inference Minimal \(SI-M\))] TJ ET 0.267 0.267 0.267 rg BT 177.960 532.198 Td /F4 8.7 Tf [(24)] TJ ET 0.271 0.267 0.267 rg BT 187.597 534.579 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 190.007 532.198 Td /F4 8.7 Tf [(51)] TJ ET 0.271 0.267 0.267 rg BT 199.644 530.691 Td /F1 9.8 Tf [(: The SI-M \(Danish version: \(Bliksted, Fagerlund, Weed, Frith, & Videbech, 2014\) )] TJ ET BT 26.250 518.786 Td /F1 9.8 Tf [(consists of short \(15-53 seconds\) videotaped vignettes with professional actors interacting in everyday situations. The )] TJ ET BT 26.250 506.881 Td /F1 9.8 Tf [(exchanges are either sincere or sarcastic. The sarcastic vignettes are either with simple sarcasm, meaning that they are acted )] TJ ET BT 26.250 494.976 Td /F1 9.8 Tf [(in such a way as to imply the opposite meaning to what is actually being said, or with paradoxical sarcasm meaning that the )] TJ ET BT 26.250 483.072 Td /F1 9.8 Tf [(exchange of words is meaningless unless one understands that one of the actors is being sarcastic. After each video, the )] TJ ET BT 26.250 471.167 Td /F1 9.8 Tf [(participant was asked four yes/no questions about the interaction. Correct answers to the questions for the sarcastic videos )] TJ ET BT 26.250 459.262 Td /F1 9.8 Tf [(required interpretation of paralinguistic cues such as tone of voice and non-verbal cues such as posture and facial expressions. )] TJ ET BT 26.250 447.357 Td /F1 9.8 Tf [(The test comprises part A2 and part B2. Part A2 consists of five videos of paradoxical sarcasm and ten vignettes that are either )] TJ ET BT 26.250 435.453 Td /F1 9.8 Tf [(sincere or with simple sarcasm. Part B2 consists of exactly the same dialogue as the ten sincere or simple sarcastic videos from )] TJ ET BT 26.250 423.548 Td /F1 9.8 Tf [(part A2 but with sincerity and sarcasm switched. For this study the participants were shown all 25 videos. Each video was )] TJ ET BT 26.250 411.643 Td /F1 9.8 Tf [(shown once, and no feedback was given. Total number of correct yes/no answers \(0-100\) was used in the present study.)] TJ ET BT 26.250 392.238 Td /F4 9.8 Tf [(Reading the Mind in the Eyes Test \(RME\))] TJ ET 0.267 0.267 0.267 rg BT 215.322 393.746 Td /F4 8.7 Tf [(25)] TJ ET 0.271 0.267 0.267 rg BT 224.959 392.238 Td /F1 9.8 Tf [(: The RME revised version consists of 36 photos of eyes expressing different )] TJ ET BT 26.250 380.334 Td /F1 9.8 Tf [(emotional states. The participants were given four choices of words and were asked to pick the word that best described what )] TJ ET BT 26.250 368.429 Td /F1 9.8 Tf [(the eyes expressed \(e.g., serious, ashamed, alarmed or bewildered\). In order to pick the correct emotion the participant needed )] TJ ET BT 26.250 356.524 Td /F1 9.8 Tf [(to be able to attribute mental states to others thereby using Theory of Mind \(ToM\). The participants were also given a list of )] TJ ET BT 26.250 344.619 Td /F1 9.8 Tf [(explanations of all the words in the test and were encouraged to look up the words if they felt uncertain of the meaning of a )] TJ ET BT 26.250 332.715 Td /F1 9.8 Tf [(word. The number of correct responses was recorded \(0-36\).)] TJ ET BT 26.250 313.310 Td /F4 9.8 Tf [(Semantic fluency)] TJ ET 0.267 0.267 0.267 rg BT 106.444 314.817 Td /F4 8.7 Tf [(26)] TJ ET 0.271 0.267 0.267 rg BT 116.081 313.310 Td /F1 9.8 Tf [(: The participants were asked to name as many different animals as they could think of within one minute. )] TJ ET BT 26.250 301.405 Td /F1 9.8 Tf [(It was emphasized that all types/categories of animals would be correct. Categories \(e.g., birds\) as well as specific animals )] TJ ET BT 26.250 289.500 Td /F1 9.8 Tf [(\(e.g., eagle\) were accepted. The number of different animals named was recorded.)] TJ ET BT 26.250 270.096 Td /F4 9.8 Tf [(Lexical fluency)] TJ ET 0.267 0.267 0.267 rg BT 96.157 271.603 Td /F4 8.7 Tf [(26)] TJ ET 0.271 0.267 0.267 rg BT 105.795 270.096 Td /F1 9.8 Tf [(: The participants were asked to produce as many words as possible within one minute beginning with each )] TJ ET BT 26.250 258.191 Td /F1 9.8 Tf [(of the letters F, A or S. It was emphasized that it could be all words in Danish except proper nouns. The number of different )] TJ ET BT 26.250 246.286 Td /F1 9.8 Tf [(words produced with F, A and S were recorded and added together for a total score.)] TJ ET BT 26.250 226.881 Td /F4 9.8 Tf [(Lexical alternating fluency)] TJ ET BT 148.710 226.881 Td /F1 9.8 Tf [(. This fluency test was developed by the researchers based on the most common first-letters in )] TJ ET BT 26.250 214.977 Td /F1 9.8 Tf [(Danish apart from S and F. The participants were asked to produce as many different words as possible within one minute, )] TJ ET BT 26.250 203.072 Td /F1 9.8 Tf [(alternating between words beginning with the letter K and words beginning with the letter B. It was emphasized that it could be )] TJ ET BT 26.250 191.167 Td /F1 9.8 Tf [(all types of words except proper nouns. The number of correct responses was recorded, and improper alternations were )] TJ ET BT 26.250 179.262 Td /F1 9.8 Tf [(counted as incorrect.)] TJ ET BT 26.250 159.858 Td /F4 9.8 Tf [(Semantic/lexical alternating fluency. )] TJ ET BT 196.943 159.858 Td /F1 9.8 Tf [(This fluency test was developed by the researchers based on a category that was )] TJ ET BT 26.250 147.953 Td /F1 9.8 Tf [(thought to be very broad and one of the most common first-letters in Danish apart from S, F, K and B. The participants were )] TJ ET BT 26.250 136.048 Td /F1 9.8 Tf [(asked to produce as many different words as possible within one minute alternating between types of food and words beginning )] TJ ET BT 26.250 124.143 Td /F1 9.8 Tf [(with the letter D. They were told that the former could be anything you can eat, and that the latter covered all words beginning )] TJ ET BT 26.250 112.239 Td /F1 9.8 Tf [(with the letter D except proper nouns. The number of correct responses was recorded; improper alternations were counted as )] TJ ET BT 26.250 100.334 Td /F1 9.8 Tf [(incorrect.)] TJ ET BT 26.250 80.929 Td /F4 9.8 Tf [(Trail Making Test B \(TMT B\))] TJ ET 0.267 0.267 0.267 rg BT 154.638 82.436 Td /F4 8.7 Tf [(27)] TJ ET 0.271 0.267 0.267 rg BT 164.275 80.929 Td /F1 9.8 Tf [(:The participants were asked to connect circles alternating between numbers in numeric order )] TJ ET BT 26.250 69.024 Td /F1 9.8 Tf [(and letters in alphabetical order. The time to completion was recorded.)] TJ ET BT 26.250 49.620 Td /F4 9.8 Tf [(Stroop interference test)] TJ ET 0.267 0.267 0.267 rg BT 136.230 51.127 Td /F4 8.7 Tf [(28)] TJ ET 0.271 0.267 0.267 rg BT 145.867 49.620 Td /F1 9.8 Tf [(: This 100-word version of the Stroop test consisted of a simple reading task and an interference )] TJ ET BT 26.250 37.715 Td /F1 9.8 Tf [(test. In the interference test the name of the color and the color of the ink did not correspond, for example the word blue could )] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(3)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Huntington Disease)] TJ ET Q endstream endobj 235 0 obj << /Type /Annot /Subtype /Link /A 236 0 R /Border [0 0 0] /H /I /Rect [ 312.9390 756.2769 322.5763 765.0952 ] >> endobj 236 0 obj << /Type /Action >> endobj 237 0 obj << /Type /Annot /Subtype /Link /A 238 0 R /Border [0 0 0] /H /I /Rect [ 131.8815 736.8722 141.5188 745.6905 ] >> endobj 238 0 obj << /Type /Action >> endobj 239 0 obj << /Type /Annot /Subtype /Link /A 240 0 R /Border [0 0 0] /H /I /Rect [ 170.3647 622.2294 180.0021 631.0477 ] >> endobj 240 0 obj << /Type /Action >> endobj 241 0 obj << /Type /Annot /Subtype /Link /A 242 0 R /Border [0 0 0] /H /I /Rect [ 177.9600 531.3962 187.5973 540.2145 ] >> endobj 242 0 obj << /Type /Action >> endobj 243 0 obj << /Type /Annot /Subtype /Link /A 244 0 R /Border [0 0 0] /H /I /Rect [ 190.0067 531.3962 199.6440 540.2145 ] >> endobj 244 0 obj << /Type /Action >> endobj 245 0 obj << /Type /Annot /Subtype /Link /A 246 0 R /Border [0 0 0] /H /I /Rect [ 215.3220 392.9439 224.9593 401.7623 ] >> endobj 246 0 obj << /Type /Action >> endobj 247 0 obj << /Type /Annot /Subtype /Link /A 248 0 R /Border [0 0 0] /H /I /Rect [ 106.4437 314.0154 116.0811 322.8338 ] >> endobj 248 0 obj << /Type /Action >> endobj 249 0 obj << /Type /Annot /Subtype /Link /A 250 0 R /Border [0 0 0] /H /I /Rect [ 96.1575 270.8012 105.7948 279.6195 ] >> endobj 250 0 obj << /Type /Action >> endobj 251 0 obj << /Type /Annot /Subtype /Link /A 252 0 R /Border [0 0 0] /H /I /Rect [ 154.6380 81.6347 164.2753 90.4530 ] >> endobj 252 0 obj << /Type /Action >> endobj 253 0 obj << /Type /Annot /Subtype /Link /A 254 0 R /Border [0 0 0] /H /I /Rect [ 136.2300 50.3252 145.8673 59.1435 ] >> endobj 254 0 obj << /Type /Action >> endobj 255 0 obj << /Type /Annot /Subtype /Link /A 256 0 R /Border [0 0 0] /H /I /Rect [ 312.9390 756.2769 322.5763 765.0952 ] >> endobj 256 0 obj << /Type /Action >> endobj 257 0 obj << /Type /Annot /Subtype /Link /A 258 0 R /Border [0 0 0] /H /I /Rect [ 131.8815 736.8722 141.5188 745.6905 ] >> endobj 258 0 obj << /Type /Action >> endobj 259 0 obj << /Type /Annot /Subtype /Link /A 260 0 R /Border [0 0 0] /H /I /Rect [ 170.3647 622.2294 180.0021 631.0477 ] >> endobj 260 0 obj << /Type /Action >> endobj 261 0 obj << /Type /Annot /Subtype /Link /A 262 0 R /Border [0 0 0] /H /I /Rect [ 177.9600 531.3962 187.5973 540.2145 ] >> endobj 262 0 obj << /Type /Action >> endobj 263 0 obj << /Type /Annot /Subtype /Link /A 264 0 R /Border [0 0 0] /H /I /Rect [ 190.0067 531.3962 199.6440 540.2145 ] >> endobj 264 0 obj << /Type /Action >> endobj 265 0 obj << /Type /Annot /Subtype /Link /A 266 0 R /Border [0 0 0] /H /I /Rect [ 215.3220 392.9439 224.9593 401.7623 ] >> endobj 266 0 obj << /Type /Action >> endobj 267 0 obj << /Type /Annot /Subtype /Link /A 268 0 R /Border [0 0 0] /H /I /Rect [ 106.4437 314.0154 116.0811 322.8338 ] >> endobj 268 0 obj << /Type /Action >> endobj 269 0 obj << /Type /Annot /Subtype /Link /A 270 0 R /Border [0 0 0] /H /I /Rect [ 96.1575 270.8012 105.7948 279.6195 ] >> endobj 270 0 obj << /Type /Action >> endobj 271 0 obj << /Type /Annot /Subtype /Link /A 272 0 R /Border [0 0 0] /H /I /Rect [ 154.6380 81.6347 164.2753 90.4530 ] >> endobj 272 0 obj << /Type /Action >> endobj 273 0 obj << /Type /Annot /Subtype /Link /A 274 0 R /Border [0 0 0] /H /I /Rect [ 136.2300 50.3252 145.8673 59.1435 ] >> endobj 274 0 obj << /Type /Action >> endobj 275 0 obj << /Type /Annot /Subtype /Link /A 276 0 R /Border [0 0 0] /H /I /Rect [ 312.9390 756.2769 322.5763 765.0952 ] >> endobj 276 0 obj << /Type /Action >> endobj 277 0 obj << /Type /Annot /Subtype /Link /A 278 0 R /Border [0 0 0] /H /I /Rect [ 131.8815 736.8722 141.5188 745.6905 ] >> endobj 278 0 obj << /Type /Action >> endobj 279 0 obj << /Type /Annot /Subtype /Link /A 280 0 R /Border [0 0 0] /H /I /Rect [ 170.3647 622.2294 180.0021 631.0477 ] >> endobj 280 0 obj << /Type /Action >> endobj 281 0 obj << /Type /Annot /Subtype /Link /A 282 0 R /Border [0 0 0] /H /I /Rect [ 177.9600 531.3962 187.5973 540.2145 ] >> endobj 282 0 obj << /Type /Action >> endobj 283 0 obj << /Type /Annot /Subtype /Link /A 284 0 R /Border [0 0 0] /H /I /Rect [ 190.0067 531.3962 199.6440 540.2145 ] >> endobj 284 0 obj << /Type /Action >> endobj 285 0 obj << /Type /Annot /Subtype /Link /A 286 0 R /Border [0 0 0] /H /I /Rect [ 215.3220 392.9439 224.9593 401.7623 ] >> endobj 286 0 obj << /Type /Action >> endobj 287 0 obj << /Type /Annot /Subtype /Link /A 288 0 R /Border [0 0 0] /H /I /Rect [ 106.4437 314.0154 116.0811 322.8338 ] >> endobj 288 0 obj << /Type /Action >> endobj 289 0 obj << /Type /Annot /Subtype /Link /A 290 0 R /Border [0 0 0] /H /I /Rect [ 96.1575 270.8012 105.7948 279.6195 ] >> endobj 290 0 obj << /Type /Action >> endobj 291 0 obj << /Type /Annot /Subtype /Link /A 292 0 R /Border [0 0 0] /H /I /Rect [ 154.6380 81.6347 164.2753 90.4530 ] >> endobj 292 0 obj << /Type /Action >> endobj 293 0 obj << /Type /Annot /Subtype /Link /A 294 0 R /Border [0 0 0] /H /I /Rect [ 136.2300 50.3252 145.8673 59.1435 ] >> endobj 294 0 obj << /Type /Action >> endobj 295 0 obj << /Type /Page /Parent 3 0 R /Annots [ 297 0 R 299 0 R 301 0 R 304 0 R 306 0 R 308 0 R 310 0 R 312 0 R 314 0 R ] /Contents 296 0 R >> endobj 296 0 obj << /Length 13372 >> stream 0.271 0.267 0.267 rg q 15.000 -207.176 577.500 984.176 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(be written in green ink, and the participants were asked to name the colors instead of reading the words. Participants were )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(instructed to complete the test as quickly as possible and to correct their mistakes. Only the time to completion for the )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(interference test was used for analysis.)] TJ ET BT 26.250 724.262 Td /F4 9.8 Tf [(Self-report of psychological distress)] TJ ET BT 26.250 704.857 Td /F4 9.8 Tf [(Symptom Checklist -90-Revised \(SCL-90-R\))] TJ ET 0.267 0.267 0.267 rg BT 227.246 706.364 Td /F4 8.7 Tf [(29)] TJ ET 0.271 0.267 0.267 rg BT 236.884 704.857 Td /F1 9.8 Tf [(: The SCL-90-R is a 90 item self-report inventory designed to reflect the current )] TJ ET BT 26.250 692.952 Td /F1 9.8 Tf [(status of perceived psychological distress. The participant is asked to rate each of the 90 items on a five-point Likert scale )] TJ ET BT 26.250 681.048 Td /F1 9.8 Tf [(ranging from not at all to very often according to how much they experienced each symptom in the preceding week. The )] TJ ET BT 26.250 669.143 Td /F1 9.8 Tf [(scoring is based on nine primary symptom dimensions: somatization, obsessive-compulsive, interpersonal sensitivity, )] TJ ET BT 26.250 657.238 Td /F1 9.8 Tf [(depression, anxiety, hostility, phobic anxiety, paranoid ideation and psychoticism. Added together these yield three global )] TJ ET BT 26.250 645.333 Td /F1 9.8 Tf [(indices of distress: Global Severity Index \(GSI\), Positive Symptoms Distress Index and Positive Symptom Total. For the current )] TJ ET BT 26.250 633.429 Td /F1 9.8 Tf [(study raw scores were converted into T-scores standardized to a normative Danish sample stratified by gender)] TJ ET 0.267 0.267 0.267 rg BT 503.639 634.936 Td /F4 8.7 Tf [(50)] TJ ET 0.271 0.267 0.267 rg BT 513.277 633.429 Td /F1 9.8 Tf [(. Higher T-)] TJ ET BT 26.250 621.524 Td /F1 9.8 Tf [(scores indicate greater degree of psychological distress. Only the GSI score was used for the association analyses in current )] TJ ET BT 26.250 609.619 Td /F1 9.8 Tf [(study.)] TJ ET BT 26.250 590.214 Td /F4 9.8 Tf [(Statistical analysis)] TJ ET BT 26.250 570.810 Td /F1 9.8 Tf [(Results for the background variables are presented as medians and ranges. Pearsons r and Spearmans Rho \(rs used for )] TJ ET BT 26.250 558.905 Td /F1 9.8 Tf [(skewed distributions\) were used to assess the level of significance of correlations between the cognitive tests and the SCL-90-R )] TJ ET BT 26.250 547.000 Td /F1 9.8 Tf [(GSI scores and also to investigate the level of significance of associations between performances on tests of social cognition )] TJ ET BT 26.250 535.095 Td /F1 9.8 Tf [(and executive functions. Lastly stepwise linear regression analyses were used with SCL-90-R GSI score as the dependent )] TJ ET BT 26.250 523.191 Td /F1 9.8 Tf [(variable and scores on each of the social cognitive tests that were significantly associated with SCL-90-R GSI score as )] TJ ET BT 26.250 511.286 Td /F1 9.8 Tf [(independent variables. For each regression analysis performances on all of the executive tests \(Lexical fluency, Semantic )] TJ ET BT 26.250 499.381 Td /F1 9.8 Tf [(fluency, Lexical alternating fluency, Semantic/lexical alternating fluency, Stroop test and TMT B\), age and UHDRS-TMS were )] TJ ET BT 26.250 487.476 Td /F1 9.8 Tf [(also included as independent variables. Plots of residuals were used as model control and the alpha level was set to .05 \(two-)] TJ ET BT 26.250 475.572 Td /F1 9.8 Tf [(tailed\).)] TJ ET BT 26.250 438.969 Td /F4 12.0 Tf [(Results)] TJ ET BT 26.250 419.015 Td /F1 9.8 Tf [(Table 2 shows the median and interquartile range for performance on all tests of executive functions and social cognition, as )] TJ ET BT 26.250 407.110 Td /F1 9.8 Tf [(well as the median and interquartile range for the standardized T-scores on the GSI and the nine symptom dimensions of the )] TJ ET BT 26.250 395.205 Td /F1 9.8 Tf [(SCL-90-R.)] TJ ET 0.965 0.965 0.965 rg 26.250 -207.176 555.000 592.500 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 385.324 m 581.250 385.324 l 581.250 384.574 l 26.250 384.574 l f q 348.000 0 0 576.750 35.250 -201.176 cm /I4 Do Q q 35.250 -207.176 537.000 0.000 re W n Q Q q 15.000 -207.176 577.500 984.176 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(be written in green ink, and the participants were asked to name the colors instead of reading the words. Participants were )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(instructed to complete the test as quickly as possible and to correct their mistakes. Only the time to completion for the )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(interference test was used for analysis.)] TJ ET BT 26.250 724.262 Td /F4 9.8 Tf [(Self-report of psychological distress)] TJ ET BT 26.250 704.857 Td /F4 9.8 Tf [(Symptom Checklist -90-Revised \(SCL-90-R\))] TJ ET 0.267 0.267 0.267 rg BT 227.246 706.364 Td /F4 8.7 Tf [(29)] TJ ET 0.271 0.267 0.267 rg BT 236.884 704.857 Td /F1 9.8 Tf [(: The SCL-90-R is a 90 item self-report inventory designed to reflect the current )] TJ ET BT 26.250 692.952 Td /F1 9.8 Tf [(status of perceived psychological distress. The participant is asked to rate each of the 90 items on a five-point Likert scale )] TJ ET BT 26.250 681.048 Td /F1 9.8 Tf [(ranging from not at all to very often according to how much they experienced each symptom in the preceding week. The )] TJ ET BT 26.250 669.143 Td /F1 9.8 Tf [(scoring is based on nine primary symptom dimensions: somatization, obsessive-compulsive, interpersonal sensitivity, )] TJ ET BT 26.250 657.238 Td /F1 9.8 Tf [(depression, anxiety, hostility, phobic anxiety, paranoid ideation and psychoticism. Added together these yield three global )] TJ ET BT 26.250 645.333 Td /F1 9.8 Tf [(indices of distress: Global Severity Index \(GSI\), Positive Symptoms Distress Index and Positive Symptom Total. For the current )] TJ ET BT 26.250 633.429 Td /F1 9.8 Tf [(study raw scores were converted into T-scores standardized to a normative Danish sample stratified by gender)] TJ ET 0.267 0.267 0.267 rg BT 503.639 634.936 Td /F4 8.7 Tf [(50)] TJ ET 0.271 0.267 0.267 rg BT 513.277 633.429 Td /F1 9.8 Tf [(. Higher T-)] TJ ET BT 26.250 621.524 Td /F1 9.8 Tf [(scores indicate greater degree of psychological distress. Only the GSI score was used for the association analyses in current )] TJ ET BT 26.250 609.619 Td /F1 9.8 Tf [(study.)] TJ ET BT 26.250 590.214 Td /F4 9.8 Tf [(Statistical analysis)] TJ ET BT 26.250 570.810 Td /F1 9.8 Tf [(Results for the background variables are presented as medians and ranges. Pearsons r and Spearmans Rho \(rs used for )] TJ ET BT 26.250 558.905 Td /F1 9.8 Tf [(skewed distributions\) were used to assess the level of significance of correlations between the cognitive tests and the SCL-90-R )] TJ ET BT 26.250 547.000 Td /F1 9.8 Tf [(GSI scores and also to investigate the level of significance of associations between performances on tests of social cognition )] TJ ET BT 26.250 535.095 Td /F1 9.8 Tf [(and executive functions. Lastly stepwise linear regression analyses were used with SCL-90-R GSI score as the dependent )] TJ ET BT 26.250 523.191 Td /F1 9.8 Tf [(variable and scores on each of the social cognitive tests that were significantly associated with SCL-90-R GSI score as )] TJ ET BT 26.250 511.286 Td /F1 9.8 Tf [(independent variables. For each regression analysis performances on all of the executive tests \(Lexical fluency, Semantic )] TJ ET BT 26.250 499.381 Td /F1 9.8 Tf [(fluency, Lexical alternating fluency, Semantic/lexical alternating fluency, Stroop test and TMT B\), age and UHDRS-TMS were )] TJ ET BT 26.250 487.476 Td /F1 9.8 Tf [(also included as independent variables. Plots of residuals were used as model control and the alpha level was set to .05 \(two-)] TJ ET BT 26.250 475.572 Td /F1 9.8 Tf [(tailed\).)] TJ ET BT 26.250 438.969 Td /F4 12.0 Tf [(Results)] TJ ET BT 26.250 419.015 Td /F1 9.8 Tf [(Table 2 shows the median and interquartile range for performance on all tests of executive functions and social cognition, as )] TJ ET BT 26.250 407.110 Td /F1 9.8 Tf [(well as the median and interquartile range for the standardized T-scores on the GSI and the nine symptom dimensions of the )] TJ ET BT 26.250 395.205 Td /F1 9.8 Tf [(SCL-90-R.)] TJ ET 0.965 0.965 0.965 rg 26.250 -207.176 555.000 592.500 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 385.324 m 581.250 385.324 l 581.250 384.574 l 26.250 384.574 l f q 348.000 0 0 576.750 35.250 -201.176 cm /I4 Do Q q 35.250 -207.176 537.000 0.000 re W n Q Q q 15.000 -207.176 577.500 984.176 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(be written in green ink, and the participants were asked to name the colors instead of reading the words. Participants were )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(instructed to complete the test as quickly as possible and to correct their mistakes. Only the time to completion for the )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(interference test was used for analysis.)] TJ ET BT 26.250 724.262 Td /F4 9.8 Tf [(Self-report of psychological distress)] TJ ET BT 26.250 704.857 Td /F4 9.8 Tf [(Symptom Checklist -90-Revised \(SCL-90-R\))] TJ ET 0.267 0.267 0.267 rg BT 227.246 706.364 Td /F4 8.7 Tf [(29)] TJ ET 0.271 0.267 0.267 rg BT 236.884 704.857 Td /F1 9.8 Tf [(: The SCL-90-R is a 90 item self-report inventory designed to reflect the current )] TJ ET BT 26.250 692.952 Td /F1 9.8 Tf [(status of perceived psychological distress. The participant is asked to rate each of the 90 items on a five-point Likert scale )] TJ ET BT 26.250 681.048 Td /F1 9.8 Tf [(ranging from not at all to very often according to how much they experienced each symptom in the preceding week. The )] TJ ET BT 26.250 669.143 Td /F1 9.8 Tf [(scoring is based on nine primary symptom dimensions: somatization, obsessive-compulsive, interpersonal sensitivity, )] TJ ET BT 26.250 657.238 Td /F1 9.8 Tf [(depression, anxiety, hostility, phobic anxiety, paranoid ideation and psychoticism. Added together these yield three global )] TJ ET BT 26.250 645.333 Td /F1 9.8 Tf [(indices of distress: Global Severity Index \(GSI\), Positive Symptoms Distress Index and Positive Symptom Total. For the current )] TJ ET BT 26.250 633.429 Td /F1 9.8 Tf [(study raw scores were converted into T-scores standardized to a normative Danish sample stratified by gender)] TJ ET 0.267 0.267 0.267 rg BT 503.639 634.936 Td /F4 8.7 Tf [(50)] TJ ET 0.271 0.267 0.267 rg BT 513.277 633.429 Td /F1 9.8 Tf [(. Higher T-)] TJ ET BT 26.250 621.524 Td /F1 9.8 Tf [(scores indicate greater degree of psychological distress. Only the GSI score was used for the association analyses in current )] TJ ET BT 26.250 609.619 Td /F1 9.8 Tf [(study.)] TJ ET BT 26.250 590.214 Td /F4 9.8 Tf [(Statistical analysis)] TJ ET BT 26.250 570.810 Td /F1 9.8 Tf [(Results for the background variables are presented as medians and ranges. Pearsons r and Spearmans Rho \(rs used for )] TJ ET BT 26.250 558.905 Td /F1 9.8 Tf [(skewed distributions\) were used to assess the level of significance of correlations between the cognitive tests and the SCL-90-R )] TJ ET BT 26.250 547.000 Td /F1 9.8 Tf [(GSI scores and also to investigate the level of significance of associations between performances on tests of social cognition )] TJ ET BT 26.250 535.095 Td /F1 9.8 Tf [(and executive functions. Lastly stepwise linear regression analyses were used with SCL-90-R GSI score as the dependent )] TJ ET BT 26.250 523.191 Td /F1 9.8 Tf [(variable and scores on each of the social cognitive tests that were significantly associated with SCL-90-R GSI score as )] TJ ET BT 26.250 511.286 Td /F1 9.8 Tf [(independent variables. For each regression analysis performances on all of the executive tests \(Lexical fluency, Semantic )] TJ ET BT 26.250 499.381 Td /F1 9.8 Tf [(fluency, Lexical alternating fluency, Semantic/lexical alternating fluency, Stroop test and TMT B\), age and UHDRS-TMS were )] TJ ET BT 26.250 487.476 Td /F1 9.8 Tf [(also included as independent variables. Plots of residuals were used as model control and the alpha level was set to .05 \(two-)] TJ ET BT 26.250 475.572 Td /F1 9.8 Tf [(tailed\).)] TJ ET BT 26.250 438.969 Td /F4 12.0 Tf [(Results)] TJ ET BT 26.250 419.015 Td /F1 9.8 Tf [(Table 2 shows the median and interquartile range for performance on all tests of executive functions and social cognition, as )] TJ ET BT 26.250 407.110 Td /F1 9.8 Tf [(well as the median and interquartile range for the standardized T-scores on the GSI and the nine symptom dimensions of the )] TJ ET BT 26.250 395.205 Td /F1 9.8 Tf [(SCL-90-R.)] TJ ET 0.965 0.965 0.965 rg 26.250 -207.176 555.000 592.500 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 385.324 m 581.250 385.324 l 581.250 384.574 l 26.250 384.574 l f q 348.000 0 0 576.750 35.250 -201.176 cm /I4 Do Q q 35.250 -207.176 537.000 0.000 re W n Q Q q 348.000 0 0 576.750 35.250 -201.176 cm /I4 Do Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(4)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Huntington Disease)] TJ ET Q endstream endobj 297 0 obj << /Type /Annot /Subtype /Link /A 298 0 R /Border [0 0 0] /H /I /Rect [ 227.2463 705.5627 236.8836 714.3810 ] >> endobj 298 0 obj << /Type /Action >> endobj 299 0 obj << /Type /Annot /Subtype /Link /A 300 0 R /Border [0 0 0] /H /I /Rect [ 503.6393 634.1342 513.2766 642.9525 ] >> endobj 300 0 obj << /Type /Action >> endobj 301 0 obj << /Type /Annot /Subtype /Link /A 302 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 -201.1755 383.2500 375.5745 ] >> endobj 302 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/files/2016/11/table-2-HD-0003.jpg) >> endobj 303 0 obj << /Type /XObject /Subtype /Image /Width 464 /Height 769 /ColorSpace /DeviceRGB /Filter /DCTDecode /BitsPerComponent 8 /Length 62212>> stream JFIF``C   %# , #&')*)-0-(0%()(C   ((((((((((((((((((((((((((((((((((((((((((((((((((("L  !1V"7uAQT#26aq3B$Rb%C&5F4D)!A1Qaq"2ѱB ?v<=y:.e6Yî."7!wl~5FSDRZJ T6@#@>,oތ~}29nXq m1,<\C+i:ZRBTI'GG|՚ʕj#Hb3aAuhJIBO #[,oތ~̹V{mjd]V K%CZc~cUU(%~c~cS7F?uURW7F?u>c~cUU(%~c~cS7F?uURW7F?u>c~cUU(%~c~cS7F?uURW7F?u>c~cUU(%~c~cS7F?uURW7F?u>c~cUU(%~c~cS7F?uURW7F?u>c~cUU(%~c~cS7F?uUTҞC[gǟ@GeяO|X߽UJ _|X߽GeяUTGeя^}2W7F?u>Ѱc~cV#7b\nq`rJ޸$[Э,,r؍*lD6qL!֭H#C`xGVO!-Ϡ)@)@)AruYzW`ߣ\ {u7mcnj$5e)%Ɯ_X.,: !-;$J:ɔ|d\LKDZ [zBF8LȹKF[V#Lq,r:\U_>/ZeʗtVl}s.$? XNwּh)J)JRR%nCէz^!=O--1=$q99i8 9D^G5g::/;ϠJ̗Ӱvd?>+;G2_wN?9 T`Q~};hK,z,̽K7.mjV@Vͦ[8C+# xC{"N hy~ W5`b6y.%n7ZAuť {;G jvd?>^Z?9յO1)'O"4%t5|-Is$$Fdi_R; hIKG2OwAWJvM')[EXy']Ki<[X}e\1 'Ǝڝu}N:TBvo{uҥOh._ HQ?r l{hIꑕU*Wvd?>%';ϠJ̓ם~s$GqtwiSӭϱ@~(JKR^mJRB[Py+nhK*R~s%Gq/;ϠJ̗Ӱvd?>+;G2_wN?9 T`Q~};hK*R~s%Gq/;ϠJ̗Ӱvd?>mR>~s%GqT^?9v̗UW-;G2_wZuٱ4d X"7GS\BR): H$st*򹵺)qm34vCN.WV'+5YzK܇O/;ϩ[-vq^wV&2CgsmꐮACrzUUJܽ)ޥxUAYEpu١.4’A ',g2K'po;ֹ-ҁrHQ9i)JG8)C5`3'̈ #uXA|J^' _P)A+ǢԳ~cfeiuSIV嫢ݙOe.*m6vuKPi'G$ZK gFQO, 4H<>h%:7#1rABihV<;ƴkU+ʑjneNv5 ۅc~dZcT@@W-FO[vN~b;ku >6)J-I+{Jrˏf;y}]qJ"HALKqTYHNL|{ì+no0rRmO5sGvrR8 J@9ipƠ^ c 䶅ܮJt{Fl0KK 2$pA+dltX-Z/F%6dI+R^Jx0O-<N%*r%SMsP BTtv4cgsYK~Sg~9ćPme "2նHp}\NkTyR(j ul])=$+`hvhQX CB[iƒZH=:$.3KnRXOܤ4@T{QJR R R R R R S}KlꪥmR>< R R n4#z^y\ZAq b[( WIɈͷB8\#{,KLP$8z8[RK\[򔎑B.q6ueI—?5]Xg=L ޽l; wi7hK*%7m:.hhPo}ۯ"@d\m>&BRRB[+;LisS*ܨ9.Kȕ&%R8BHRRNj5 4qXEeM #pCjߺAksmgm6љM%}rå68ۑ^Fοyb!Xy$S%Koed[ ߌ*6v*crS)u҄pt6pHq75l97%qԲFP6}Z+oIju21jpy) IBBv#y'įk jPYV=?5t>aڷY6["2且AG@i\ҝ|}Y61p2-cþwXC:oVjzjrKKLu3-#KP}RH̑x﬩="H[vG؍W:p€)Pdq Z4\B5UΜF(* $ +I<n<Ͻ-q)ӅG|{Z ~p<>WzT? ʷ#BS4R kDcyw-+Ђ#PC@q jO*oo]]V#@p'\ւGyGnJ,]vp'6ml{kɲ;5ԆRie IRvtM£]V21bh}) $/i!GxI:'n"o]+?O[Gw~V!m [-o.S @zڄ :\Di#Dk﫯,Uq_H2ؾEDZu1d3:睲iz>o4O&Hmr%-DaC@W O5=f;rvtNr:"٫lR[B<{5b/$)6w{H?R"̺uuq )*J{ F~I'4h ֩>VKX+e. F}U h;G()J)JJ})>|yURJym}U)J)JH%bc. 59,DkhU/x\dp\2z"1i!@9,jjE6Won&.oBvlimI (ġ’ [1c2e䘰,); 8%kH Z :=}LJq_*D:i! R2JBI'$=N'6[)>PQmn866NכTUMJRR%nCէz^!=O-zSǽKs*srכF/m(%̗Ë*y*IRGҝ-ACGH'1s-sɝulYnĤ :TN*q͓:&z) >BRJxR! %qfiJ)J ^=f^^̓׽,z,̽K7.Oq=k2'xmRWP\Ko,2Jw̎@`?Q~}sr]̧Ydt:e(4瓣@dۥS%(z C P3SO&nsuk}~s$GqkƞbSOʞDiJjtZI!H4:Ե䛍leov[aB;a $JTF7&mǕGʣT+ei)p$%iH $xy Gqi׽~s$Gqy';Ϩx,ޜ~UP֔Z(mJ $4pFذ=Jgvm/7txK%)yDo`@jۜы^n`qZuZ5xZqD9uYeEfCR\Xlq!O$ G+YRo&eMv%-c* I]e?wxnWo: li-yDf#\r:,)N% q8`sJF!R&Ud>7aX]Qc)}O P o&lqҬ9~Q5n7i|+ Ю))H<Ԃ47gŃ2,w_,ۘiN8!wnhiԝ|5It?9~5O1)'O"4%t5|-Is$$Fdj&tKĨsa I>ch Pm9hS (RN7&mǕGT+ei)p$%iH $xy U^̓Ӱd?>Zr6zqWUCZB E< lPQ z5ŅT{Ciyŕ%j^)K#{Tqڱlb(x7 coRR6Tӊ=̲ ?*#0C\E:wF^]JϿZIK.!smV@d Z*e䘬Ju6W)QZU * hIN-'.9s$]6 Ğ. Fn\lV$XwQ*Jʔk [gf 8P`!rBۈ<@$6AebK< Ji/%.dw7?k;vd?>ثJzZO y+_! JGe!+;G2_wN?9+;G2_wN?9`Q~};hKꪔ~s%Gq/;ϪPJ̗ .֮o̬MđJqHTҞC[gǟ@/;ϧ`Q~}URWvd?>~s%GqUJ ^?9Ӯ͉ jn8(2BIA#@7VOD^/<ͮK 1-wy}0De޿v B\q:Vҕ8Ug m+px[nB$}hcT s~t% C!e.;A+Z@$A;Hs`[T<)sHAjFg/ Cr ^ Ru9$G{`7dm6z׮v[pMuFU4 l@ \lͺq"6+/b}za0rF% >)PFu "rOVʙoa^ɹHd+ز6wJ#I*'1Ey_-+ݐӪG)ԝ*$i[ݟ7hWA I1<6@!M!+JJT 'dq3x;-NE!-RB$>PP_VTj:vxi>4 KnW B|AD~s%Gq$Y*H)awiho?WXUT`Q~};hKꪔ~s%Gq=bVe.4njdަHl|qͷR9kԯIېuicrzU)ydԇכŮz޷zۗ<{Է?jḢKZU5/T2 #'c$_ zRW-Dz~V>[\.\yV%É&HB!j)Pj\cHvUŐmT7uh m[_?SHkRcfeYuUR,z,̽K7.((((((((((((((+mUJ})>|yT(((:sݔ[V(_ *PqiA{AJ)J Kdֻ|x0[ꢰh* ĒI?OYtzK܇OUR%nCէzҞ=[ǁT6Z[n$,lzSǽKs*/{gnaav]*c\GZR 4eDƁ[1#e .v Ju*)ѫRRcfeYuf׽,z,̽K7. (PAVoU'_˳c~LJ?u hܱFM싊s A9rRKFS^vД rPN NG1лےmS.:T:Ү!ԭ<=fҭ[7Mf˳c~Gpͻ,b eO:ҢTO HBG#DjR%b(9Bb>VҀ ݽꑒqصfƽ˳c~J~4]1u 4uNkl defn&.iOV^ umP З}䟾~]{GO.<=a.x7rULk_:qV8OX$$E[Y-v9ʎ꤅-nM$#”6>ōϗf˳c~"MEmPzƕgscvy - -tpA!@$=" 6f.!U!KŢ4]ѫRyvoo<77&S[,; W !ɱl&6[A@HQZ .sQYHʀNM/\Rw^^;(G_T!*rwrqm87]{GPo7>MW)f T_5# a]`n,p˟ ʴk).9"Aie`+[> -H]voo<77ExMobUH! ǁsh)Ik2ҷ˳c~ٿ?uu6kXUthڑhrru0hV^R4Sl$˳c~ٿ?u'dwG7;'_SQULt Kn)—M^*L5[Ch x^^A[yvqo{LJ?u kvԤK(KeJ*! ikBQ"@THJvqk<85EJvqk<85A+LJ?u3na}RlXm6BdWgdRJym}˳c^LJ?uUJ _.<={gƽU(%|85߿:uۑYbfX%SWyhmKX =[z}67^]{GO.=,CglkT<+\xh\HiNRՠ9m2zhpRB:Rgno.=f2sDvjd;sw  nƂaDpI$.rd.bxV װ))R xh^f˳c~tW.|y7tf|&ܗُomA8Ԡ(V<# s8Hr}r[q-%kmP $I*$߿:˳c^ѣc p[ʄֻM?%|85]x{GUT׿:ͥeN-٬ͫv5O>F@<9hyGԯIېuicrzUMK\)ޥxR i4Vś.**v)YjB́JO'B- \Yeb̩"p :TOZ'G)h ;}OAj+nyTהyiW@Xr;ܥg3iD{%47#'Brʞ{UJR,z,̽M3.mHZ T x"zXYzo]UPJcG¡}ZK*2fBUĔP :)IX5VDTi* }29+/8݄OʩA4`v:T74Yc2]K-8WXZ0x;$߇-D= rK e┥RH;'d￝PהsnD\DxHdXmvQIfjb>V纕ܜ21N*Z +F G(i@(&nDjrUkq(D\{'`5<ѭöYj}. lK-kZ xHR*${T *1:.(/%qy>;8l!$urn;c)U}r*UwqS?E(L_TZ #Z=|oV~Iq"1gi\IyG3˿**BGGXĈ0;1ۈnkBA% ZR$V q(vؐΕ8d+5% @:'CBG-w~5J{k.X7g1uНqeI:B)#'i?x5dbnszHTTP!N.$(+3Ts*f$[]MCjaTHRO3ʳ-Xm>miŞ.+ps'{RRyZ݊UR R R S}KlꪥmR>< R R Mo+u? bQ:l( s;: CYk t9I\ R̝pNI83/U4m:Bd) Wpl~!:8 弴ۇkK)RdCa=ϰcz$d)Ni ꔮIކ·3[PM\0 qSi2C8p8SI'O+Di*Ly֚RM6NJ,&I-c;&Il) )d to+RTIېuicW~A/VIܛ 27&:¶?h?z1rzUU>,oތ~}2PJ2>,oތ~ꪥ>,oތ~}2Prs>gF\hf>2i,n-L![$c~cSEfQGڊ|FeяOl#X߽3:>VAfr_ޱiukB8[࢝'(y#8ǵ{ n[! NԤ8xhGz1"\Mzm2{%eռފtH3RW. dHVИGq2rv}Z@JҊ$ n Ra27F?ul-N!^}aHϻ1Z;%9HK[-[)I[S|C hGz1ϴl#X߽bN6uW*C6 B!%AG@lYVܮqs%:[jLwcBTT O"Ғ{$0Ѱc~cWh?z1b̺ Ù mBzn2r6ZBT8IGeяO|X߽UJ _|X߽GeяUTGeяO|X߽UJ _|X߽GeяUTGeяO|X߽UJ _|X߽GeяUTGeяO|X߽UJ _|X߽GeяUTGeяS03==$_e+,g-6鸳I -~"J})>|y|X߽GeяUTGeяO|X߽UJ _|X߽6,oތ~ꫩl"ٮqC+)fWi7TId $VG z|#X߽F,oތ~^MILv4!֜SkR $UT>,oތ~}2PJ25Ůֻ|VKd5ͫ{NONtpەgAzyyJ STBIW$ GWEs霨0og.ڦ:S RRT7žh_y괧 &9 JU E*=C'Z<6,O>il#q+&7JGa6Zl l7JY]-AGbkh $}{_anZ+{_anZv^㼗[zK܇Oy/}-Of+eDpiWi-CKkn:ȝP6Pܽ)ޥxUR/JxnUP)Q9_HvZpy~4v[EkZm<}ǽIt2'¿c.ꊹH˼\ H[X)#cCd-)AJ)J ^=f^TJCOJI$k?S],z,̽K7.jH~r"ՏfŮ/1XHFWP)zOP$6qV˔K4V&Jlֆ-)KjOHPNe*ߑKofR)jgZOu\ iJ5yʧTr'CN2f':+!1~smui5 ^o?y ̭u&Bd\QK))R4Uɮ.{v̳`MֵJjsuq^}.(9@v*5I1[]n-ņ;)R%\H;*Vhs+=0)yǞNYZ29['Be)YT7$[%LpV\D!G=@ ĸVKQ7$v%- Zˎ*l-\iO!ޫڻ-?]f'^qqv,LOmp҃%JG>1\;^.2b˷lwk(ۃ^M9i$lu2?o}knv N?oxʐ@P)'47nu_4+p+hC7ĐI}ܦL,زI7w,%Nҗq>r'|]R,r;36}pfT[K<*iTRU4+%ؙp\dl&K2,RTihNu^F#њ\PT.')s`!}͚eIcIR@Iɭ_JRTIېuicW~@zSǽKs*n^R< =-#9|=2ciGGJTPT˾^7;Ō[$LwzX/Z$VkI҂.G`bV@}ri=KJBR' P o47X/bs";aHǝuP_yu8tZҟu*JRWEfUJ2,߀v|yy/ˏȩ=$d{i<4$yIIu To-N\~E;yhKr(*R~O%9qy/ˏȠJ `p*|MZ[ge-,ҶR@'$jz)A+Ǣ~R7S,z,̽K7.Jҕ PRuGb94~*gޛE16mq,ɶ88KR련`(lBJNŘyBTMTV>Siۋpti̕|~>CP.q:Ąr-űCy77[?*j \;:yYu5D@y[E$:[^-$h.q-W旋ZCa_uȍlVzhČ۳V1[Kͥo||3m\l\i0nlEv\Tw|m-4($UT}Cە|r~u6 NRU[;}ܒ+RRRRRRRRRTҞC[gǟUU+mURWAu,:C-e RT o_ZIShm)VA#v?^qp᷻w E ct$'TD<%[;K߲ [wx͊#NhZ'{ [AGUp*4XԵ[HJ9 g$I(= <ƖTNH̊酱u"քI&;ZZJP"oc'$ړiUrkr{ ڼy+z$7Ǿb7dž'%)TؒJu2@N^Pƺ|O!Náwp[nr;gyIp1lm/ @~V?k dEyEZc 䬪ב`y@AIQY6Rί)Z[jh-P8qIzo`;LJURzK܇OUR%nCէzҞ=[ǁU5-rzUM=P])2o+uܻIꟕ5Nur:7YNN-ٷ]#ʏ%ۋJR /\(V$u- ?I/ֱ\z͋\ QprF @Dksѕ(@~M"MeE|I^ u8ukZj)J ^=f^UU+ǢԳ~ꪁJRJRJRJRJRJRJRJRJRJRJRJRJRJRRJym}UTҞC[gǟAUJRJRJRJRJRJRJRJRR%nCէz^!=O-zSǽKs+{ydz&ܦ&,6W!ґ5#v$6qbBTږڗnR6y|'lRܥc9vSZ={SCj\S#g:wee,\ L6(7(봥 y<'{ŒùoAC-#-ygDH5J)JRWEfX-)$>],z,̽K7._:e՗| m\ɩ=}`wE9ž4դ덥-G$'owKG2Ow\|+ʬSlأwqfenŻ۞#!q rC]WX !)Y ~,,ї̳vV6ѐ":äJ)*JZ ۡv̓Ӱvd?>lXIηjsY xʒAl(1|)F l-91rY S(yi1 ַI2jηU5nuqL&.9#Q_hnJx+:ȩ%eAԶ$߮|$yDPYFרq+YZA+{kP?~fd9.{{l]vؑ"" 8 ?P.)MVxN zSmeymuׅy(9,+K)I:-.kCq[4=~s$Gqciœ,z"JqMHGN m iIA/s/H6'Aۢkbd6R'$wK.qҁVFO_w s{Ǥ;%V;yuCR뒀S(H)Pf-e; hIKG2Ow\7Wb]K켹%eHTWFib~/I9.U3 J6Юh[IH@ J\`d?>8;n17/&;_܏އ'wgH]'rݏ v)usPqo}a Z7ıDZXob P }{qcq DE3~,G%eAl(%ewIH#E4y<';Ϩ6T2/iw#ꐦ[ pmCZ-"|ߪ-*ab] dŒ"O4m2˪A_ J@Q ZwgMU:۠I2~HhW+JA$=uOo1xgILVqp8$sNHjlhtK"5\UO&oAԖHO>Z}:WH]t׫RCR">Ihm@m[硾|\:տ%';ϧ`?Q~}s_cvK=wwاAq#-"ABBPJV_ّÈ!j8e8qaKA $:ˈ0xz @#Dܭ6%L;6Unuَ +P(<N $%)ւ3(6 TsfP$)!h-V(<~]~s%Gq㊲θI1q&]SRƐRJIJ ^?9M9p7i/SA"<ѠI S}Kl~s%Gq/;ϪPJ̗Ӱvd?>A+;G2_w^v̓](9Q&űY2|h6N8y%GaZ VXm-]-ņPCp<(?@I@9.!d"!q)vCn8PJP>7$HX 9{i;HeI;K6ڭ;t5݄u\A夨~lNsowț1a wUh5F6K}-ǺL%%C*#P$썦sҡǹ692=kJ[At iY'Z4Ui y&&P[mI]TK^jVӤ@$btLNPHr3s"%I=Dꜽ-2y˓W&d|Dwۊ{VD+i`8o)\l2ˑXj[KG2Ow^̗U(^?9v̗U(%{hK{6ĭ]\iդɽLn:+GDsK^!=O-I,5&;ImJ$ Ȃ>꛹zSǽKs*FqlneO密v g-m0S/P\;+Z=ڭ~w̏j=P $J,%Ri +Z&e7{*nAf<C`r a'{E)JPJ2,߀^=f^UT R R R%RC- @l8A$$I5((((((bֻeNDJi2~"A(RZJ=淴1Eb 6"Ce Fali(HYP)@'ĸTȭ++Vy'<.YRTҞC[gǟUU+mURRRVtYCvS!nDwa[ |*NƿC]ͥ(nƷqKEEKZvI=绸 P)JP)JP*W~UU+_?]ZǠ\)ޥxUR/JxnSS12Df] {{wSdU!l|&2nr#F$Hᴧ;Dx2ۏ>ġ4B6Q Pi8N3b]$盛j.=o%fkʯ f<(Z$J^ˬZ*P JNM4H[2 r!Zke*[Dr4bv\۾$窱,nEݶTdʸ!:„)`Ă{A@Z/7_#®7 =߄ĆVliLӞLhXZmHe**J5TqڸÏ oqڐd%R-4 N4"-T뚖"Fԅ:";qZJ!#i&_ 4wf1>˥%mpyJMZRY1vyɊ셸|{h(ղVRy3ݠ+UqwziqsZLǛ[YNk;JQ?D{$EƐs[XMP-!AQk,o\qJaLZRT%)IRw<ꖔTұ l/JRyHxu5o_~=>ɛ R-#J-,0YC:('{"iPICbBdf˖u[K_)Wx\;'&׈@]Ҕ+%;]szH<@ }IJN%}nV,R mW[q*pA|uJZ^uKKZr[D$z<ηϥJV?H| x>ƈ[ZW.cK';KKiK2g]&Aj3ya6\RPWU^W+~ Ax] *l\N)H<\GCyu¡ϟ&{Sn[rc)60- Iw-UWlAr9rش$L}:8@JKz]Ҕ R R R R S}KlꪥmR>< R R օ_m[e+R X Vڕ&/ilC9 홶0yLm(u=Yb<@fƢ p #OyJ̗Ӱvd?>+;G2_wN?9 T`Q~};hK*R~s%Gq/;ϠJ̗Ӱvd?>+;G2_wN?9 S}Kl;G2_wS00ZI26ExY*zh;_]G4 s ^?9v̗UR{hKÂZ?9~ W=Y;]m#DًKlw$Fͷ0MJqIJfYKKjx;եdxHsVlNuM%"z|dqd".8A)cb!a)ؕ~FB\mc#iI#` Sʕ);G2Ow^̗UTIېuic~s%Gq=bVe.4njdަHl|qͷR9h(n^R< k<{Է?tjLG.͞]7e$JZP ӖV!A%gi!:/prcztv6BQiH>@q-/8$'CkCgS\<^s snln."V@ڇ=txez'V>48Kv}iqOKťE*) Nl̑kTI+(%zXYzo]TԷK3/R gt^9ҫH%NMSL҉p@S|KnƢ_uK]2JP-𺭓\*]& qyֻĖYq7_UV'[H<[o<ԶϏ>IG!d20$ Tcdr6iV6o1-rie<[HJJPpjQNGFڑN\kiZw꼃kCDu kƳrUH8.4JvSeIR?ugXsg=L޽l; wjDb&6;ÒCv4oGbҒK5 ҒØ2_eL$rd(!?JTl]F93UQr]*LKDG qIxdM-zx!($$hkC:*W˳c^LJ?tT_.<={gƽUR|85]x{GAUJ׿:yvqkU*W˳c^LJ?tT_.<={gƽUR|85]x{GAUJ׿:yvqkUJV1LJ?u=Jʝ[uY#B7WXk|}i ysP$ֈPܽ)ޥxUR/JxnUP)JP)JP)JPJ24߀♎AZBGy#=f^U5'1Ȭsjr;,Fuِ0q%!FS<#a+^q<~u}K\TcД706Kyo5pLl*LtM}1Coy/ iTi ޒb~;[*wN6%D|<.CT|ݲk*$LJdo6"Z ¤i*RTB:U[5)͐TeV2SEҭX(Zxz )SO"*!Rxxմr:=Xn y!Y$%Τ(7R8v@H'btc{n?6HN3wgfzg)3JKlJBS[bu-uM8+YOzNV&Ǥ* .]y% E l;>Fs~fƆcC|aELX-qTź4T{ P4 /6gc5F<ԣ|qk|j|x;<>o:laL[t1^u4QHQR'kQ*;'|ɬHX ֧auh\R_/GΧjf ˥d![mr^'DJY@hI-=A?}UuJXyk1R]jTH#F}np P$\OMXeDJ:Ox@$wq)Z\\z͈`>z6ȍZ}ԑCrK[aSh~{ri4ʤYsk%q-V܎\WyT{l "pFmJqGH V\k5>'C gZOVDRRBQct|uϦR|>oV$A4BJcNmd.s[R,;!!haA$$'clo[t\Z5Lmդh[Q}[)yìGC"5 0fvJH.'(soc2e5@hmDO$U))E)JP)JP)JP)JP)JP*VO!-ϪS}Kl*JP)JP+ \,Yk 2%XW.#muL/C\OXs=ǧVN'hzMC2\RmS,u%e>hi\;i^.no1vԛ\gX>[@\0GTmA]eY2ĵDa' :NB :ձc1}Uݸ >KO K%]ZVFPH'g3M%{.6BA~Μ e/%D.V>!zJR^Q($V[GxLFM3*~mK[d]%%h 6Ȇn]QǓjŭo]Y,k=LF8dI$I$I;4N߮2{LY/X-"07v֒2)QR;tT9'$VL)Kew z/;zJ ";ɭB>.|M`Iu-:Ч I墤455F!io#7ԛj-xzxt=SY7]un*Z 68G*x}-Kjɒ)._ 6(+_?]ZǪ/r?c.^R< [<{Է?(((%zXYzo]UTK3/R )J)J)J)J)J)J)J)J)J)J)J)J)J)JJ})>|yURJym}U)J)J)J)J)J)J)J)JJV1ꪥzK܇O <{Է?VO-)J)J)J ^=f^^}azXYzo]TW|_ 3XJQC +E581Ejfe)c!豒eLAH$ mͼ"-W[pZBXRKK+5^ov_l`}8RJ$H; 8TDź1rnbEqT#Z{}|"غ(ksk].3_c^m6-mW-w@}2z=g nF!8Ku"~ u6 o{#\=~fqf@cLhI$'j=h5Qqk*E>_4.VRsv%>:o Ju0*{\RL{=YWo)>*'14a6XT!FH,\Nlvϝh2+V jxm)SDB eG"4JR?Pj<͗Z]9-Җ8:RV':pk2ߗ(kC7r/NFXP x)+ҲRBUVEH ,THYr%0p)Y=Vc*P*' kށ +;`yݮpiHi֨kiD[+N$(67ʻqUgK㾃L R V҂yZsuG{r)l1b( $[䄍G:O-ԟLgp::\aHDZᥨ`\)$@1Nci¬nNy<\E9iBVu yhloQveX>6dIQrE:KIXQ.)D®Go[hO37;lI.LEm:Āg% !:HH"70{啉݉ƙqEmȷ0,qp IPކ[oߺ 69uԻ  P wUM~0~cn7?mURWn7?mOfV-iZ$^m]\in|ptH].zK܇O <{Է?VO-)J)J)J ^=f^UU+ǢԳ~ꪁJRJRJRJRJR*,y2iP$)'G@5(((((((((+mUJ})>|yT(((~;2 e[t|iC`(o<}@)@})AَBi A @WڔRTIېuicW~@zSǽKs*n^R< RRRcfeiu!W,z,̽K7.$$1FadL6 dfh>mxС6'# eLp%YdM ]Xm%)޹'+I<H'j;=Ձk.fsz=q"LE4[x )(>jy+' 77C YRVp]>;H`ayiJ^HO5&/B0|BZ) J`:˅_p՛א!Ss~*Z}.bOUc* SN uupn4[Pc*+gHsi)q[#{Rp!C!T1yN#vkGKo-JBZOT aWݯi2Ym]/_ŝvԦؘ)/NjRJVRAʆfcLڳL6kDkK)l<'`?!ƽW[f@ m\U(m'#h%;$5#i_!/MEV᲼Pux@OBvwh*VO!-Ϡyqk/e<85A+9Ljqp8׸_ʪ!ƽWE YUu+l컨& yVKm~js<&ҷs~+9r'.6ƣ$ng31-@łr% մ&|r8\hOA)W-LBb8J \B@H$Ck}%@ 2ۄY얹$IBFӣh57W&Kb/!::j#G!VM*-2mp^ЦBRAH#@\[aS#%Q֣"[|ϖ5kMٍB^prR#?p(4q{Lב"6ZWww³\@tHA!iq&zէA*W/8 ̥mR><[o<ԶϏ>KǬ&EW&q<:k뿻miAY`ݟB[\d!A %;?p.K<,nyn78)"A1#FJd@(w߭{,x1Y i! @ҨH$غɵ@zfcЧ%dq21'܈! MVPI=Ѱc~cVB3W6$3եe :Z[!op!JTROyyz{ esR`To(rH\;x=>Ѱc~cWh?z1%g15ؔ"Lnq $g毽 ѫj*W7F?u>c~cUU(%~c~cS7F?uURW7F?u>c~cUU(%~c~cS7F?uURW7F?u>c~cUU(%~c~cS7F?uURW7F?u>c~cUU(%~c~cS7F?uURW7F?uLp}C$+D>!+m>c~cS7F?uURW7F?u>c~cUU(%~c~cWhGz1\>Gh\P O#TR'$ghGz1x#cZZMtJyDŽ4>u~-mθTR66xiDhGz1x6|7LgjL89NyI_'\m<[RZ]8'uNq-,8t8A`lyoAw| eяO|#X߽Ճ7>pC.Ԅκ)K@0B  yfϣ{kU5cn3JQDPJVN՜vGVO!-Ϡ)@)@w}2eễ"0\5>C+Lb#%J#ﮉ^T=Sd pܝD/1!1T2KJ REg̭9/(Yycmn B; FȫJPe_!G5VeZM'*]c}db6\ D[wKl[}1Zuh]$M_҈,&Wk|A]*,dʐG-%ZB3rn IufJueNkoF(FN:͕9wyjl'5[JU R /r?cUJV1/JxnS$MexH+ c$:*Ws^)9LjqpT_!_o!IXy9o`(n^R< k<{Է?O.Nues'3iIhzR֞oJPAJsJ##ﮋg/3YC%,E}ͥ|-hJ\2hs~LVhǔ%Ӱ%\@sj'}·2ql(*<6r%-9pp6 jSnJ򽢔(%zXYzo]TԷK3/R o]} K,Eao)EīzJ8N|_=.ޥ\m$ʊ1ԕ$J<`p](~x 0qEKT[zrw|~5R!/88;*GY'}ӗ8πCr".OuHRZˋԒ/fr KW=1 QHAPP$sWf0* RK\J +KD r#jsp\eʶA~[Wr:{*#eOuIģ {_?öJf-z^Jx”\<<*H)Uz,Nvk¦K~T[ Qb!(Z)y GPzk5`wbޫژc4G W 44\"fjnlTDFÌP6F&b)ۺeDu9+̷?!h ,0ِRGTRNA': [RWoɎ.:fQJTͷ^m,Ԗ[ p۾zЎ"APH.q%RHS}Qpo|;뺱;M:رXZ8e*V 9DU$Wge߲+;ߵgelw;JWu*^i$$s\p-FB.-64;꺔8S\]\Hż5hcJzSKa.H.$,x#)yFf {qM;΄@oe)PO:K|x^qdŸ-Lq!ĸ Y)G-'*3sHWwmz@y_{2d%HJPzĖIpdr:}9qvd;Qnm%#) k=aeyPjF=݆ҹS|]KKmKwEEmBB͕HTW-(i❞ĐRRA羷%6%m(L uqV(ӎ%AJ򽪥)J)J)J)J)J)J)J)J)J)JJ})>|yURJym}U)J)JsSun&=a~)')e +%yh5'w;m7ğda-+JfxВlopiu@-&.ͷ\BTSd,FζSy6=kZH%L[[k]io Wtƥ,jnu)'ڏ3k[]+&_z/ [y,&ˋ!7nIȋofUɰW['QAY T'| +ef*^'/jb;RS.Ͱ *Imiҁ@;5t{})b5ŒĹrߚJV489[u jc Y_KM) mg|JRRI#Zv5 ;v2L{uHa~)JvB@z$걭Vv2o$}b3:J%)Ҳ6H!DMzPyE2R6C)Gu[D`sWw\+VL J.\$)t% {G"ar˓b7) .-T 󪊥=l}OmƟ*D4 u- RO0BJA E_)JP*W~UU+_?]ZǠ\)ޥxTjVO-i= ZdAq%=%(VXI/|ɐgSY $uIJңuƸK]z@RwUl@22gq &PBj7ǭrF6cPu*iHk%)BV!cu85)@)A+ǢԳ~ꪥzXYzo]UP)JP)JP)JP)JP)JP)JP)JP)JP)JP)JP)JP)JP)JP)JP*VO!-ϪS}Kl*JP)JP)JP)JP)JP)JP)JP)JP*W~UU+_?]ZǠ\)ޥxG1G+mqtw˗<{Է?d2ԖbKhuPHRT4A}'1y[uL.2p;U k\\"_r7۾sKacRF'[ֿZLͅw߾XhܑkiF4Tx]?5;%˔^#mƬCb'U Jŷ]BRxO{_anZv^㼗[A+{_anZv^㼗[A+{_anZ1^iҵԔZ򊿤Dr]^O>=/}w$qy#%upu+plTA4tɼ=i҅M֧[*@1>Y` ] dhr[C x+CQ?G} ] lZ 2RE%P[_ZEI* O4 u'k:.BOHIDY'*` ]*syMAj,O\n'x&bv֡ 침gqqՓθՏkրSyBcftr+E2-N4mu)lijơݲuJlYˍśYldj r䩆&Kd)-"\ty}`ʪ?W(:,+JXs%&;lmlj 4b0xzIWnH6>M@sGM\-9DjIF$2'2[i**l<_I) nt jS5 ShC{)kR9ZThftǝ>!H?1/J qBISOK$|́*e;}i{_anZe;}j{6a[-$嗻HڸIj[^qоD07z]JV1/JxnPΈOĔﶦHQI)P#zO-WC]TQD4[|.tS UZ{1!e|yURJym}U)J)J)Jknv N?ox@P)'4eJ)J)J }͚e8uV%KQI'@s&zK܇OUR%nCէzҞ=[ǁU5-rzU$A3WR$#^oz޹ꤎEӲ1A2xr:G y\G[c3h2'卑&_NրlwMNoFC*vZ< ^!hQXƸհyjlnfR1WBlN<ҵ%4?xBr̬JQJR,z,̽K7.E'}U{ǢԳ~ꪂSdTE'}Uk憢?;ɢZ"m+\Kg(P@qLHs~ K6۵dTE'}Uh=$a.C[.KLp\BT6 FXVOlGJ3aÜÎ 1m )q(Qq T En{Qw&IUN] {{wV6~2YcCj%.ZW;$ $Acsۼ㬦ñpP\} 8VI 4#3dTE'}Uk]&CMpKn3Uw mĬSaCa\: ŮZ%CÔ9dt['[ v;o)m6XZ H] {{wSdUβc[ CP~@`:QGB HHR67SI񱛇M/1 &M1ʒ/20R6r<yPdT9E'}Ujfg k#oYJDMp iIR<\=h*O 4I$̉3?XUճ?s¸TVKaAiD S}Kl%盛j.}ꪪ%盛j.}ꪪ%絛;Qw&IUUu/+ݫ4zMU.4dj3Q< Uô9շ$盛j.=Ch93w54re-ER>RT֓peս\aLCHJBT<uOj.=ڋ2Oon/K&OW 도JG#Y+\2d*%Y r*<~ *B[AvYh"n-.] {{wSU=s]befOT“@rBGZT Syi@u'ʭ]ݛzeN]m9-!p {Qw.IU^L۾}zN>%8" qejXi! R2JI'$=j.}ڋ2_onj.}{6\f-w{KڸvFPVzRBK'` n }ۭxڦIC!dwlWǑ2Ͷ)H{N$()J ^=f^UU+Ǣ~ꪂj@\d̒:"6ڒ/[IQ #G|l;&df`}S.4IPWy媚T-41r땾t$:Ed0d $Am)I*JR[y֧+Լ.e.Uѹ=pB5:RZd}yU->RQ%7e)!%JR pp)cA$[hZ['̹N:/\KA͛ R-#J-,0YRjN ;<frҸuV֤yiQX}ĸ6A@NT=9 @{X\4085z5Z,Gv+;ȶ"5eZk}XXyĭ(O<[Jnf#Z/ uC%Rh6NX'軭=s=%ޡL˿֖< R R ∺x}ԢьOWh))_v 5)IZpZ9v2Ê_";,h HX?YX. GDDYmCF;:U R /r?cUJV1/JxnUTҞ=[ǁUT[:#&6-C5LVp!J+;G2_wN?9 T`Q~};hK*R~s%Gq/;ϠJ̗Ӱvd?>+;G2_wN?9 T`Q~};hK*R~s%Gq/;Ϡ[o<ԶϏ>~s%Gq3 s+ noq$_煒Dy@2*;J/;ϧ`Q~}U*Wvd?>~s%GqT^?9;of3Gg6!Φyu԰ BJȃCCT&#Cd^ͩPea*7enwRh $p#5a̶vVRKyRԣI'/)\~F%#\ MdNxA'Dr+N;o%)w;Py7_#$Щ\~(0;9u7+˭6RVPDj0b+:QݒÎsR AJ:e*NjدI$Ep m@( tO0ka;G2_wTUR{hK;G2_wAUR%nCէzv̗m[|/kuͫIz!6uHWzSǽKs*^R< ٔ[+fNFmnT;OW8{ ֆŹ7ew kSEbZq㰒U§9I?q ekq2q ׾ ZxAQ~ MZ'lاX$R.MMVR NtH{pۥҼjJRWEUJ2,߀\6m3ۿK*jUQj%e6RI*H'DZv6zqWUCZR}jΌY(@h(x|J{ {RD0^oY7TȎxuZd8np%{ך֒+E~q-C։2䇂Xmԩ)8J/`hNba2Lr#7>?.6$-Qwl).$:KO˵öLs~5Py):-4 \K5iYsXݥ^> lN&DoEB:K*:{C|v-VxU)Kp%B?#Ĕ-JJT]}Xf.Jo.#ȀԸk** EHl8TqYiø&e6c1#[Lu*ZBI|]Қ#mSiH!_jAJRRRRRRRRTҞC[gǟUU+mURRW1##NإP%$S~NGR~~oUӫn$r;|Y7dͲ≶dIr+u/8 *ruo? !'$5+H/pkyV:s[V(_ *Pq'/Ki^<ꔵ9@@ D bQn_wF'" "1_Y!@+DPU!mVVoܗ!5n} VĨ=PZtIX h֪sY7~7O;lrʛ|Z RIuzm*$^U$Y*H!ݧGR\G5_Xv`EaT@$$(+_?]ZǪ/r?c.^R< [<{Է?9mg̻XF>?$ph)%ZW>5@֋t4y9Gj`aRa5F[VOx鱌~fyoY/y\an+bgCv*Ú/(ZG <;(zAM߲VGqya̍q޵BruZWP)A+ǢԳ~ꪥzXYzo];Qw&KUAUJE/}U;Qw&KUAUJE/}U;Qw&KUAUJE/}U;Qw&KUAUJE/}U;Qw&KUAUJE/}U;Qw&KUAUJE/}U;Qw&KUAUJE/}U;Qw&KUAUJE/}U;Qw&KUAUJE/}U;Qw&KUAUJE/}U;Qw&KUAUJE/}U;Qw&KUAUJE/}U;Qw&KUAUJE/}U;Qw&KUAUJE/}U;Qw&KUAURJym};Qw&KUS6螒/3 SҦC8HQ>Sã@';h^] {wSdTT^] {wSdTT^] {wSdTT^] {wSdTT^] {wSdTT^] {wSdTT^] {{wSdTT^] {wSdTU+_?]Zǧj.}{6\f-w{KڸvFEqr -!~M-Ųm\ED EZ]$=qAk6Uv0aKr40Hp_?lL%깡|ׂ$˿}ar}[ܕu/>yL ҉GZBZYb"Kߞ[cR)[*G"wîxHKy B 8:SNv?PA#KF%;x HKx~CUWd8ڐQĔ8F3:y+2GVҙyo!KbʉV#5g&d9[w%&:$lOVw);'~yZ"FC/[q!|%Z $h!)JF@K*Cڑ)셲a:ۈO:oo.gq۝pcz$vezL8uGO=5u҄tqSd}w1KhR Ji 쨤;Dtu0\EKe=_WRSãξ< \7$>\w912]}T)<ĀPk| }&-C /$,Wh|<|yURJym}U)J)J)J)J)J)J)J)JJV1ꪥzK܇OK9c:kmϨ꼶+ou|Z[~R2-`xږVHPT:?W{ZM(vC)RQڲ F9¤Y$UE6 i!{kI<"wξ,` Q+c#Z ֈln0;RR=J(PTJ@N&5x9fd[ bȊWWքu´SJZ(s?t_ͦE jBRE(#G}Ƒ]ld޸(Ċ@JTJ%.D_+'z~rW+{ĦK]QG A_x|xcyQv="xN5{/7njըb|q.SL~D ƊJI>y'dk]KlƅV<:E"ދ-6:ߋ sFJwV}aA*(19l`炧K6+Ǵ2)Ӎx[ۈ7P$;9یyPKQYp0;Sp4|$V|@_G(pq+-M,$8ێ6R|tr^S"d8U0i[IVw#W߱Vs{m 4I0XgJ Ju-|9+ Z}VVy@V0Fh%P:-BOVί6eۯY'le\ zQ# lE\ 1ߺI1dݹFI[)ulm#G+4s[0YXm-GR*P4 }[NcWaQneZZuK a:$8wXْ,"<2"F}o)JRA$<:yc6Z=5 \T&4RҮ-ƼxU7'5=ܜݾɅr Ԥ+9w'].-[ڇD-+Xh rf{-}VX̹i:i*I)B:~t5 4&ۃ\$LXа#ĮyIζVZ,2.\%, N TË'܃t6FuݑݭށhtOD7pql:`)'W w|n>OhuqTbl< !)<(66>=[w|{ Cx$1"lOZQWxNZ[ :S)$:p[&0¸Ϯry* BӁ|ABG~OsrB$ERn>J󏉮uŴmV%E@"4{ty0V>dˌ"cgni- wrJoKA)IRvRy- ZX_GWx-͵cXno#:ڴH:RRA~0~c9f܈H!G> endobj 305 0 obj << /Type /Action >> endobj 306 0 obj << /Type /Annot /Subtype /Link /A 307 0 R /Border [0 0 0] /H /I /Rect [ 503.6393 634.1342 513.2766 642.9525 ] >> endobj 307 0 obj << /Type /Action >> endobj 308 0 obj << /Type /Annot /Subtype /Link /A 309 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 -201.1755 383.2500 375.5745 ] >> endobj 309 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/files/2016/11/table-2-HD-0003.jpg) >> endobj 310 0 obj << /Type /Annot /Subtype /Link /A 311 0 R /Border [0 0 0] /H /I /Rect [ 227.2463 705.5627 236.8836 714.3810 ] >> endobj 311 0 obj << /Type /Action >> endobj 312 0 obj << /Type /Annot /Subtype /Link /A 313 0 R /Border [0 0 0] /H /I /Rect [ 503.6393 634.1342 513.2766 642.9525 ] >> endobj 313 0 obj << /Type /Action >> endobj 314 0 obj << /Type /Annot /Subtype /Link /A 315 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 -201.1755 383.2500 375.5745 ] >> endobj 315 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/files/2016/11/table-2-HD-0003.jpg) >> endobj 316 0 obj << /Type /Page /Parent 3 0 R /Annots [ 318 0 R 321 0 R 324 0 R 326 0 R 328 0 R 330 0 R ] /Contents 317 0 R >> endobj 317 0 obj << /Length 9126 >> stream q 15.000 -119.852 577.500 896.852 re W n 0.965 0.965 0.965 rg 26.250 730.777 555.000 46.223 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 730.777 m 581.250 730.777 l 581.250 731.527 l 26.250 731.527 l f q 35.250 742.027 537.000 34.973 re W n 0.271 0.267 0.267 rg BT 35.250 766.011 Td /F4 9.8 Tf [(Table 2.)] TJ ET BT 71.559 766.011 Td /F1 9.8 Tf [( Scores for HD carriers on the cognitive tests and the Symptom Checklist-90-Revised Global Severity index and the )] TJ ET BT 35.250 752.275 Td /F1 9.8 Tf [(nine primary symptoms dimensions. Results shown as median \(interquartile range\))] TJ ET Q BT 26.250 713.754 Td /F1 9.8 Tf [(Table 3 shows the correlations between social cognitive tests and tests of executive functions. As expected we found that )] TJ ET BT 26.250 701.849 Td /F1 9.8 Tf [(performances on all four social cognitive tests were significantly correlated with each other. Performances on all four social )] TJ ET BT 26.250 689.944 Td /F1 9.8 Tf [(cognitive tests were also significantly associated with performances on tests of executive functions \(mean correlation .24\).)] TJ ET 0.965 0.965 0.965 rg 26.250 334.827 555.000 345.236 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 680.063 m 581.250 680.063 l 581.250 679.313 l 26.250 679.313 l f 26.250 334.827 m 581.250 334.827 l 581.250 335.577 l 26.250 335.577 l f q 450.000 0 0 297.000 35.250 373.313 cm /I5 Do Q q 35.250 346.077 537.000 21.236 re W n 0.271 0.267 0.267 rg BT 35.250 356.324 Td /F4 9.8 Tf [(Table 3.)] TJ ET BT 71.559 356.324 Td /F1 9.8 Tf [( Correlations between tests of executive functions and tests of social cognition. Results shown as Spearmans Rho.)] TJ ET Q BT 26.250 317.803 Td /F1 9.8 Tf [(Table 4 shows the correlations between the SCL-90-R GSI score and the UHDRS-TMS and the tests of executive functions and )] TJ ET BT 26.250 305.898 Td /F1 9.8 Tf [(social cognition. We found a significant correlation between the SCL-90-R GSI score and scores on three of the four social )] TJ ET BT 26.250 293.994 Td /F1 9.8 Tf [(cognitive tests \(the SI-M total, the EET and the RME\), such that better test performance was related to more perceived )] TJ ET BT 26.250 282.089 Td /F1 9.8 Tf [(psychological distress. The mean overall correlation was .34. By contrast, none of the correlation coefficients between the SCL-)] TJ ET BT 26.250 270.184 Td /F1 9.8 Tf [(90-R GSI score and the tests of executive functions reached significance. Motor symptoms were not significantly correlated to )] TJ ET BT 26.250 258.279 Td /F1 9.8 Tf [(SCL-90-R GSI score, but were significantly correlated to performance on most tests of executive functions and social cognition.)] TJ ET 0.965 0.965 0.965 rg 26.250 -119.852 555.000 368.250 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 248.398 m 581.250 248.398 l 581.250 247.648 l 26.250 247.648 l f q 450.000 0 0 352.500 35.250 -113.852 cm /I6 Do Q q 35.250 -119.852 537.000 0.000 re W n Q Q q 15.000 -119.852 577.500 896.852 re W n 0.965 0.965 0.965 rg 26.250 730.777 555.000 46.223 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 730.777 m 581.250 730.777 l 581.250 731.527 l 26.250 731.527 l f q 35.250 742.027 537.000 34.973 re W n 0.271 0.267 0.267 rg BT 35.250 766.011 Td /F4 9.8 Tf [(Table 2.)] TJ ET BT 71.559 766.011 Td /F1 9.8 Tf [( Scores for HD carriers on the cognitive tests and the Symptom Checklist-90-Revised Global Severity index and the )] TJ ET BT 35.250 752.275 Td /F1 9.8 Tf [(nine primary symptoms dimensions. Results shown as median \(interquartile range\))] TJ ET Q BT 26.250 713.754 Td /F1 9.8 Tf [(Table 3 shows the correlations between social cognitive tests and tests of executive functions. As expected we found that )] TJ ET BT 26.250 701.849 Td /F1 9.8 Tf [(performances on all four social cognitive tests were significantly correlated with each other. Performances on all four social )] TJ ET BT 26.250 689.944 Td /F1 9.8 Tf [(cognitive tests were also significantly associated with performances on tests of executive functions \(mean correlation .24\).)] TJ ET 0.965 0.965 0.965 rg 26.250 334.827 555.000 345.236 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 680.063 m 581.250 680.063 l 581.250 679.313 l 26.250 679.313 l f 26.250 334.827 m 581.250 334.827 l 581.250 335.577 l 26.250 335.577 l f q 450.000 0 0 297.000 35.250 373.313 cm /I5 Do Q q 35.250 346.077 537.000 21.236 re W n 0.271 0.267 0.267 rg BT 35.250 356.324 Td /F4 9.8 Tf [(Table 3.)] TJ ET BT 71.559 356.324 Td /F1 9.8 Tf [( Correlations between tests of executive functions and tests of social cognition. Results shown as Spearmans Rho.)] TJ ET Q BT 26.250 317.803 Td /F1 9.8 Tf [(Table 4 shows the correlations between the SCL-90-R GSI score and the UHDRS-TMS and the tests of executive functions and )] TJ ET BT 26.250 305.898 Td /F1 9.8 Tf [(social cognition. We found a significant correlation between the SCL-90-R GSI score and scores on three of the four social )] TJ ET BT 26.250 293.994 Td /F1 9.8 Tf [(cognitive tests \(the SI-M total, the EET and the RME\), such that better test performance was related to more perceived )] TJ ET BT 26.250 282.089 Td /F1 9.8 Tf [(psychological distress. The mean overall correlation was .34. By contrast, none of the correlation coefficients between the SCL-)] TJ ET BT 26.250 270.184 Td /F1 9.8 Tf [(90-R GSI score and the tests of executive functions reached significance. Motor symptoms were not significantly correlated to )] TJ ET BT 26.250 258.279 Td /F1 9.8 Tf [(SCL-90-R GSI score, but were significantly correlated to performance on most tests of executive functions and social cognition.)] TJ ET 0.965 0.965 0.965 rg 26.250 -119.852 555.000 368.250 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 248.398 m 581.250 248.398 l 581.250 247.648 l 26.250 247.648 l f q 450.000 0 0 352.500 35.250 -113.852 cm /I6 Do Q q 35.250 -119.852 537.000 0.000 re W n Q Q q 15.000 -119.852 577.500 896.852 re W n 0.965 0.965 0.965 rg 26.250 730.777 555.000 46.223 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 730.777 m 581.250 730.777 l 581.250 731.527 l 26.250 731.527 l f q 35.250 742.027 537.000 34.973 re W n 0.271 0.267 0.267 rg BT 35.250 766.011 Td /F4 9.8 Tf [(Table 2.)] TJ ET BT 71.559 766.011 Td /F1 9.8 Tf [( Scores for HD carriers on the cognitive tests and the Symptom Checklist-90-Revised Global Severity index and the )] TJ ET BT 35.250 752.275 Td /F1 9.8 Tf [(nine primary symptoms dimensions. Results shown as median \(interquartile range\))] TJ ET Q BT 26.250 713.754 Td /F1 9.8 Tf [(Table 3 shows the correlations between social cognitive tests and tests of executive functions. As expected we found that )] TJ ET BT 26.250 701.849 Td /F1 9.8 Tf [(performances on all four social cognitive tests were significantly correlated with each other. Performances on all four social )] TJ ET BT 26.250 689.944 Td /F1 9.8 Tf [(cognitive tests were also significantly associated with performances on tests of executive functions \(mean correlation .24\).)] TJ ET 0.965 0.965 0.965 rg 26.250 334.827 555.000 345.236 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 680.063 m 581.250 680.063 l 581.250 679.313 l 26.250 679.313 l f 26.250 334.827 m 581.250 334.827 l 581.250 335.577 l 26.250 335.577 l f q 450.000 0 0 297.000 35.250 373.313 cm /I5 Do Q q 35.250 346.077 537.000 21.236 re W n 0.271 0.267 0.267 rg BT 35.250 356.324 Td /F4 9.8 Tf [(Table 3.)] TJ ET BT 71.559 356.324 Td /F1 9.8 Tf [( Correlations between tests of executive functions and tests of social cognition. Results shown as Spearmans Rho.)] TJ ET Q BT 26.250 317.803 Td /F1 9.8 Tf [(Table 4 shows the correlations between the SCL-90-R GSI score and the UHDRS-TMS and the tests of executive functions and )] TJ ET BT 26.250 305.898 Td /F1 9.8 Tf [(social cognition. We found a significant correlation between the SCL-90-R GSI score and scores on three of the four social )] TJ ET BT 26.250 293.994 Td /F1 9.8 Tf [(cognitive tests \(the SI-M total, the EET and the RME\), such that better test performance was related to more perceived )] TJ ET BT 26.250 282.089 Td /F1 9.8 Tf [(psychological distress. The mean overall correlation was .34. By contrast, none of the correlation coefficients between the SCL-)] TJ ET BT 26.250 270.184 Td /F1 9.8 Tf [(90-R GSI score and the tests of executive functions reached significance. Motor symptoms were not significantly correlated to )] TJ ET BT 26.250 258.279 Td /F1 9.8 Tf [(SCL-90-R GSI score, but were significantly correlated to performance on most tests of executive functions and social cognition.)] TJ ET 0.965 0.965 0.965 rg 26.250 -119.852 555.000 368.250 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 248.398 m 581.250 248.398 l 581.250 247.648 l 26.250 247.648 l f q 450.000 0 0 352.500 35.250 -113.852 cm /I6 Do Q q 35.250 -119.852 537.000 0.000 re W n Q Q q 450.000 0 0 297.000 35.250 373.313 cm /I5 Do Q q 450.000 0 0 352.500 35.250 -113.852 cm /I6 Do Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(5)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Huntington Disease)] TJ ET Q endstream endobj 318 0 obj << /Type /Annot /Subtype /Link /A 319 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 373.3132 485.2500 670.3132 ] >> endobj 319 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/files/2016/11/table-3-HD-0003.jpg) >> endobj 320 0 obj << /Type /XObject /Subtype /Image /Width 600 /Height 396 /ColorSpace /DeviceRGB /Filter /DCTDecode /BitsPerComponent 8 /Length 33100>> stream JFIF``;CREATOR: gd-jpeg v1.0 (using IJG JPEG v80), quality = 82 C    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$X" }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?&pR[c8/,}Qsk@o&6=+ĬOj<{PfS*YrqwzPͩ?U7K ŷGXyXk*D7Qynk>M!m-umE5I/,䴁HueԆpU@z[*?7Xj:e'T[$_[p탴z&5[+5Hmt5B7 ʟM 87U7K ŷG4vo>zί{2j+w )$Y2`@=xIeZә"뵶ЎƋ|qk@o&N-?M2m2A7+! &3ッy[~M/o"p$e=Oq5[]XXkW6wS# ~۾M0Gqk@o&N-?MV7&I,gnO3<ۙ<ܟ zMgi"Hmcܫh698h?8?U7K ŷG<1㫿4iiWqc1DPv^+ׇA@' h>87U7]%2NsIok@&Q0o&nV~?`kao jV[{E(<rH FCS5@iVvZ\}nW37c*Ȍ]X(4-D_S4sk#_*(K]jUޕGx:&șH$;槃ΩAw%7p u~S'lN-?M ůE4O߈u"FK[Wgfý0FisVOŏxQKج`MhfxTo۸H"TM/' k~4jeo,Sӭ,h\yLP.N>l sP4tZ2iLn좹pV81 3q=zja š?U7K ůOo&{V>)5oQM6&㦡i}qj @$g4z7'`#TM[*[{ +QTyZجe*$qֽ4t9N- ?M ŷG)2(͟cS4Z_*  Hgj6^ڵ#IhYUWc?8?U7G'?U7^qߎڞiVf}-7p.!.0Rp~Ɲe=~M{Kynf?:uom@o&_S5qRukutuo\ZD$V&t8%ub*T\g G|b}a\9P̘ `;N-{h#TM''6 kiα%-)V5 PP:@ʃ3>:o|~f~nlc-lO{\?8GU7K Ů??Mטxž+ե ai 3@rXxtF~ -ּ=;Iemwqg2Ķ VNF {\gqk@o&N-/M cszdWfR >bٰr t/퍷.@XE(Z[RC8sL_S4*_GcCzV, BO]7t֯(qa<i0~JC.n#t} 4dʪII[JBpu*>yy2 3d=ga#Zl/XYR&tF E!?&x*8e2j9|CjҵROц*ԍ QV?Aek=>kr,FQ.N?3LR (Q@Q@Q@Q@Q@Q@Ph hÀ}pEy<ggt_·kawS2=EzlZ߾r!Sڑ)ʈvvqjt=b /F$X\_K6OQMgc,QbW l(y=4>'KF]i=ܹUvܥh)U5>'|;<'n,.DԈ ;$ң6٬C"twT#GЂ;Mg9O^~bSwnWf5fb>P8֛_ [_5Q"mi{Z,[tMYZ#tAPNNd\> mE/)fB8`Lveޖұ0β2?yƃdO_NCpcދѴ(DӴ !e0F:lqU4ZEs*, %`1H;WX8A#\GQۭË6+SB)b,t$t8+;W6bڵI%HȈ%?J󻟂ΓijWCQ/d"-/'s#Z-#Z%O T]7gۻvwmC:Zp&*^ \!~eaKuw*w'}I9/W~q-)DwVDa`e&y(Y:R}vDh/#fv)7>(J^6dBT}㎞3Eva@ڽ1dl[&Bc=pq,|Ykg^Ѱ5֟گ Ugw>ֻC^i|>OK9`iEvm!ca*7pO< ix_񍵭͆(wت00};h]枱鱴H-af,^MmK 2yt{/L{O/ss _H"Sk$j d8t} ILk#eB\rsT=M*[M4hEGNyĚ#i`6E[CGf`<Z?I6#޲EI$Ndr;בL~(t If+weG9Tz wVXT_8b WČL{m,%G#r|գ݌6Gl)$Jd<)-K+oEi-lҦX GpG[6r'UvFcǩ߉ų&׬TYUb{ըOn58#[Xd 7ay6'`fhX7iCv.cqS\S/Y0|nE5Le~| :IQ^fdb{iLH`ܑ8Vڥ5<_^ܷ_˕%rNI$Rg6E#ٕ*'I 7c5v_QA77w$)u2T9!y8P~khzg$֭Sg Fx(uwLWE[T<;ijVS\7 2ڲFf,AO0cC&>ǟh߆u i^5ܒIdPӊDXТBXk`NRVR4q06xpI#ƮE%PO,xuCF2( TcZ7`$ ,><YIwZȳf}_iw+] HU`ě8sh.Kfq$>ХS  #5xOZ_iBkwfPdC)*AAg˺u޴wZ턚gq`ʍ 3*8fgb[8x/~Ӯo`{ۋb Wb3G  O*߆??UttSw'G+ ,?(s߆??U/@⫣9W~XT»?]ccIQ  O*:(w'G+ ,?s߆??U1@⫣9W~XT»?]ccIQ  O*:(w'G+ ,?s߆??U1@⫣9W~XT»?]ccIQ  O*:(w'G+ ,?s߆??U1@⫣9W~XT»?]ccIQ  O*:(w'G+ ,?s߆??U1@⫣9W~XT»?]ccIQ  O*:(w'G+ ,?s߆??U1@⫣9W~XT»?]ccIQ  O*:(w'G+ ,?zzxO $n[͐^WCE7ך'kkE#B$ֶ+ We\B)PKa1&5 gkzֻ Y!ϑo)k`%rM{4xMKmmZD`[=|߻ҩ~$&5ȥo"IEK)+@Nr3/޲o {HU!mA*J0ܤNG(>⯛j_j:{iYRwh.=k#MKČZ9L1Ԏ*/XI0m\8'*d׸yxhnE =F.u8E) 0N;)uBQu[kRU@C1ѳSs}47#S[-n|cqCH]; Gǰ5{> lA ԯو#؀6 sVo| qejz}by7.= zΜNh., kXk-Ǖ/O#?|<1q27Wl>ٱۊ6Ђ-SQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEkŨ.Xc5EͷT` 3s\?Ɨᶯ=&`Z:Y;=L[w ;m iג|ݜt:W˾Ye,>5G .92JF [%n>(0(32%v3eZ/ Mn}j[{Ky.{]R7*Y$VW ƄWmGE[o#TB-*bz@/~#Vs\D!gȑXTgJ먮Emz䗖lfP3p~r zՙ>'i1<0=TKp[,s*o?;5>ΗqUxbA:HZEqOob r)ܸn?0;+펛3]Y LgT ͜,'RK$զk{p$T?7]'N+\|GƝBRkMAcd[K0篥gh_k*\\5+N}\\4xk2K Mn\oH#Vk!ÓAm1O̮5u%.>|Ҹ%MF¶(}b$he@\3RmI53iatf@-(ӎ먬/|_m,,1"8<@Q@Q@VgiW 0qŒ"4K ޛ%Ŗ:Gkkw8P#3eZO^/dO3_Gg5}Ҭgvrs;j+񄶾-Y/>nOn=hd-ơiwVB@ʃ0yuR)斀 ( ( )Q 6p{x. @%x;pqO4UEr^1{+lFWy`efXHeV!rg ׊fЭ$f`eSqHp9p;*+o j#֒8|]|ڍM Ww /( ( ( ( ( ( ( ( ( ( ( ( ( ( >!j> .4!1c1y^FYC0\ "2p3\>td]+ēlC*I.5jqϬiIe"Q69 ~5KҼm5/h>+]:\r$f ݎѓ^vQE!Q@\$IH3) $uX\dxT:{,[0āBsWJpR/YE,֓!nQz *_-#F{l.yVqZIN]"OxnuBIgokl!U~99O뗢&,!\W֊VoEGю۷ӜU\uQ]BH! p8 `q>-gm⸬aQ0 X>NÜ;Ow$۷_i7cc #qE+ Z$G$T  b.5]BOA-=X^ejN!|ESj7V\KnDڦ7ېܜxn<#- l%K2.xc[1#Ե7F9;K(qoq2E<*M?Sl`ͶE'?ɯÑkjfhKy$iA*)_g[ԼJ1ѭeۆ:w&#u[[ۋ-%69Pr9YOgԵRX$ukv-^y@j@ C23VmuX{ݭŵN@V/;7XN)\v=:-bF{q re'jЯ f uj3Hȹʡ gu[$( ( c8LZ}s97ګ]ʀɸni07ew! k]F:n'kĶ&"?,È&x` z)"|ئZA q#W,<^" A4yog&@>9_ 9|1s}27Wk>ٱ;=ӃZEKLaEPEPx"w.OSR75_lWu%i8Yq< ˲'hBo w+1Yĭ;6,268*WČdr(e:Ѧy2[hb#";_᷈$ң s1iL #w>|_'$ PsHBŚj?}rӨӓ֓KuMIVq '*@0G?1_w;mnO;'[$O7kSѰR8$8?h:]]궖E-w>kHb~Q'h@vGP )p=P`z 0=-AKEGh`z Z(Q@Q@Q@&KE&hPIKE(((P`z \J(((((LAK( J8((((((((Fk~'xz/Ú]Xo!i'AШ p:k֚/eE>7̃{G} V˾vO kZ-vñn0kץCXNm)"Z*/=i{G} KEGУ0h@QQG#-bMEBnBw\ 'Z} i c+= BЦTiz} Cs-ڡB=cKEG_ФL??PThz} >%!B0X@QQ)>-aB=IEGФL??PT_iz} >-aB=cKEEУ0X@Q})~%!B=KEEУ0X@Q}(L??PT_i{G} >-aB=IEEХL??PT_h{G} _=IEGУ0X@QPХPX@Q}(L??PTi{G} >%aB=IEGУ0X@QQ(L??PT_iz} >T_iz} _C=0$L?/QР ( 8} (!?֪խOB*QEQEQEGdo93]-8I"bѪFBWi#$})~_0mHDS^.7KyrD$R+T'`^}%D1,-2xV+r%-nbVti:NdL=C^Zut [Gi:!a'49|_:t3h6_\I {@#wrpcþ2ռU[iưA%\H"ncմ G k؄`S#<i6PKl e,r@$flω5=bqYEsheP0p@ >lWQTt5DO$s]ܾH'QE ( ( ( ( (9:޳Ou$޵6T _&] 9'Nn MS2Jeuc?^N-aQSq|ͽ7cp;4 Zi֐[,"p@(aEPEPY*wZbiERxh[#~X}9gt8e M{3{Uδ EPEPEPQ]Ldhg:8h;$Dvׁ(]GAc<ӴzPtxQ"8QG<ٵt(+k xQJ d.BmLyz& ܦo`\.I$ tEUE QjZ(>}Z_%!?ҪխOB*QEQEQES&CC0E,BOz<91Y5>Y\t%T>I>U+'<# “^#y55Y2SzTKkm^ b, [}hZěHmfxEdߏ8=߷zqm5Y4;ez3 r;sր:JB].t/ K­0HKVy|mݵLdYs+ !<`㑜'-N̷.uq,I >EPEPEPEPEPE[SaҬf2B zMYiZZڼ.c a A$`>;{, $Fˆ$a! c9'[[QX1xFTbI&O ,gc) G>qfX|r}4Eg*JX=zsPKHۋ CF"`0Ł88@5a~"oj&F '++ 1JGҁQE (((mIoss#JR)1ĸ#naæI@VnhzDwU K|0}tDg]FІ`բ~"hSor``~sjPjZ02:~f(((+3[ע ַWr[d6ʥQo= iYz6WAP#;f^1۩5)X#IgQ! )6.[Ec+u[&fdޅAؠ( m?/E}E:(]OBUj֧! V ( ( (2Dmr+c;N88^}Tti75 u"xnSJ*( BAB;KvT8QzgOwKaKogn H<0w@+8>Qy6J]?k.tvY|{@޴.|zgOP wt=CExdk6ia1cЀIx;[ml-ޜj׉$|>z(qIU5ȮI5B*meq'1J*x}fdU#ֽ&@\t_RNKk3eptY{# j5)6y%22=qEPEPEPEPEPYd#`A}qZP?k߰]sxͨ]Mj6b# ( V3|9m%t5i8.HNDf$sON@4m>-HA< U5v#! (((xb}fo<0ͳY] гv7QWEEs(߉" 5{=e2V;^{4_yn!5Pw$em@tm%m2^?(ml9QB0KEQEQEQE?\\Y\C lT0TcQoъKHOTR"RJéɤ]jܼoeDOWq@j**E,"G72'0QjQ$1ED^S(((|C]Z ո0!e8#[TP3xb~(,$iG,ȪZgWu&^@7g}k y xbihd~U5PKIEKiQΊ-?/@yKy"*N 9rréOB+6mVWLbu\9vq-#Oč7ǒ܍6PI."Q rWY^Av7bP%0U BzsTĠ) ((ʭŤ1-F:u7Zqo]YEq,zY2Ƭ~<$p4kּ/jZjk[j)6¬Wφ#$cJ$ZH4xC.ߜ0$tqp?c A@Gs$7/ [; 1 =MY𶛬isGFV$R@؎;c@KIE ZJ( ('xg$䶸lEZ+mLj˵v qԎ;v_o#[[Io/o0fKH6Vq9k[ۗqn5+Ͳ "?=F; Dr@9$}R}_Yi6)݁du^1Jn-N~ЮYKiQΊ-?/@&KkY4mB b$:\('j1+?!?u]kH[xAҒa.̡ݷuMALQ:i>xhVě $sG'^޼CVՍ<-}Xt4 61Z= QE# (20qm Y(@Պ(zm1IVv'D@o4簳{ukX` `TP4~_K,O$)"DcP>MƬEg(̠>ޕ%W'OBG~)q3S- 3LƲ n v'IE`((((((((@mF )O|H`=Oq*"*)Q@Q@Q@Q@2h"46ꮡ >` ۄhngJkZ[*(((()RI 2#Ө&Evy{J mǧ7z/OEQEQEQK@ EPQm̍,Qc;TJ^Ui+֔Zۋp LWi(ݏLKEQEP>}.! [u-W Ugu E!j8d WyBq?}SQ"eQEܐD;U-x=jdTwmƵG,-Y.uW1ʮONq޽rs৉gֵx4b;IE{wcȅ(Q@ O"'p3sݛ_kooeWBeL8+'9+:r{tshcpTb3\ ;PKqq[\\[,L%Ԋ;[HJ5K ‘͢,Ιopߑ<nUh-F1ֹ{h6 幆D8P\{l\Ԑ'_+a KmgnCBH^z;:%1A%պ4B(\gFqYZ?CQ);6h@O~n;Lޥ`Muf<[yd{)9s~3ҲoΥ9jibQ?5.w0I WwͅΑnd,90z S5 V:tn-D2$J8#@N|Woۉ.nfeBDd3n*9\x.iu)f(gFXeDۅn{Gz;SBQE ( ( (1Oku9mWx`T ˢ{,m,Qxv OГ (Š((ooous#JnLq.7Hw0FGLk~ծ# syX*I\ }M\ּAehܙP"g#צjm$'D"F R&sݽTIJOUR*)qIT:5U.S vJ4&:e\,,z`/R!,aw)eJ4;aęF0Qާ$54TE R@:QEQEkh6Wrͻl6KQo;g'&:-ޥ-֟<[4Yv:;pKkeǩXjPԱQDi+2R|R^hZEKbФp+Ǯ?,k j7$v_+FWPHl5}Z_%?oq?.c4$]^&/',[wWmW|Knگ|9iݍP=)(,N3Rb|gS|%6,v|7O2\d1zZ+>M{^mJ\abq^֒BRT(YRV1>0#gķӓ]ף9{=A8Jd0#zZp|M|l(&s~7uRƙ^7G"O=E!]op_pi-%+DcYWx9>jfK2\ 9 +%I?%Ƣbe [W›wZ}&K.'vq>S ۋ)tk."X(N%8FҞ㈬s (g[$IqҬg-`nEi(W߷q|Gl}.! ޮgSQCySPhd!ad tڟ'z/pZlZx Y1?SulR[;^3}vILN2s=|:M/u:H[۱W<+}['ߵvO((C ( )JDr,p=ak"[6Iefd$DIpAq(~6~ED~on|Q`؞U nR5 a6de,zq23٢ti$_qi O>$W\uoր ( ( ( ( *cF_^[$#F@QڛjvK#lWc ހɠ tTOuoIJNH d d9⥠(((*ާca$1[۽q,27TP*;-"n&(8'Ԛ5}6K4{ؗ|*}J P*eqՅ`2AE-Q@Q@Q@PH$PEV,u(bHdWPGQzmZwkZ\[JJGPH8 tUHu}:+ya;,OsCպ(((((Z5ЉrdU8}:d26畦PUpr #9w$ea (%_E uO+ɾ2eqcTE6.KvI܊SB\Gizqۨ0&3t#rs ҥ'hV!.txG#ǘO[<{7N+~zW>8-U +G{tj+It!QR0( ܪY='׭t;MQ+IUHfP%?jZJV#+Ad^ϊK@-_g@!#9q[k5M1C1,sɝۏ͌ᾝ+13M^ohzK:vh%Q aœxP.] ų0 a u(KMAyŇm7QI"QIg]-2g(rqRkV"]kkQ 0bK8@]&[xz-SYבZ"Wfh`c'Gam;HI)b2!ѱ\7-bŚe%į)jd9<)^k'SK4\Gtm69֊((((*9KxG hJ+LjoI/mժ[Qqr1xw>0th٩(fPlmR=aEqKz]&NMBZ HZ/*Yy?6qp+Vc[&L_=q^1+Q@Š((+:͐ku#̅> TOGZVz֩}Qiq˨+u]XH$pH^_籎Oi)\B=3hW\ހ;+]jڥhI<3ϸԵMWM3`D|pzb(((+'ZmKha]VT!v@#>hZ5; Kymm m41F*H{3EҴ;.\q'h"8So9=۠掶(quyAwg"$ӒެWT[9߰J:*8>s߯z: ( ( ( (i:wo囙egp9{}E J+K}.kwvJ$2~PMU%əed.Wp-_>zQ\徻O(,MYt! S2HZ([OtQiQΊTxmymn d9s S94 x7v5u%J\4ۇy$WW|5獴EmJ]>V4eԝ۔g=}Gd*FQE?4F=]hvh8o/ߔWCEnZMM$H-LY7zIXxLӯo,&t2;EE15隭h[+|/)1۔ T/>hײ4ړ5̭,]7VM+ ꨠY> :\Oό/ڛrjUp{pH#zr=UR \J[~$Suuҥ"Kkk[γ*[,c 2q:`]V_[AQ,JPS'Ԣ2&ŔںKv,reYI*uQ H$gyc pLcnn=뢢0_jڤ:z7PD\ ]UEaGY,I$1$O^ ( ( ( ( {X^X6oQެ@4/^<͠4ss'gnM]K1.N ZPM3LmEb1gv=YjP+Q@Š((1j $iR2][bGCsh uK;{X5LTs9֐vŞаhʀ|Ð{=y޵({QEQEQEQEVf+S2-Is(PnPpd` Ӣ3%HAb%v'9>m"hmNvHs9բ ((( Լ9jI.l7?2r0x`9*(.? fRBnm\1ff pru5E<g Y[7H㪞8=lQQhUUQ uPEP>}G\s XlGeOj$ ozIQ^ud~ FhjШ($?/s 'I7ğ!47!5z!GMjpDŽwQ?*@zƿw҅,VUȑ01## {_x7fjZV2&]rYf(Uq$ZcͽŨ1FKO+AS0 E|G5ZouE+F;";6-fvn3ȐGyFg8?Zm\:{S0c7fI?~*.Eզ:'(dz`oVݞ=qxc+߆tv6]Z2|FTcso$ oZo\xHjgy"3jW r#*e$09YڋG?82Nϗ`sm9#i _7fI>}kk׷ڦsse%YmdD(n$qZƒ^յ 77Qw1Pj gs$ҕ$ 'o7ğ!5c<{o7fIOQ_IO?&o?C}kұF('o?C}h$ J5$ {o7f+b<{o7fIOQ_IO?'o?C}kұF('o?C}h$ JZ7ğ!4Om@ץQ_IO?&o?C}kҨ5# ko7f+POm@ =|I3^1@k =|I3G$ֿ 'ozV(5$ {o7f+POm@ =|I3^F('oC}h$ J7ğ!4Om@ץbPOm@ 5|I3^Ey$ 'o7ğ!5X<{o7fI?1@k =|G3G$ ozV(y$ o7!5TPOm@ =|G3^('oC}h# J7!4Om@ץb_IO?'oC}kұEy$ o7!5Tb<{o7fI?('oC}h# J5# {o7f+bY~ (ȐgU2 Dnn]F ' zZ5Az+ 9'۟^sڰGxiYm$Kx˞Fj՗Q{n..d3HȻD7/+yWPW}U-mŤ8M˘wrn'iRXm)3 y+~ny⋏F&i"[)eF.ᕼh[$O<>_ +lFp._23:`˻{:sWsvv! ky$rp|n\cS6%2i>xTnmN 31?wLxUӁ@9=tEyR $f-ak[vё)N>_r;s?b IK+{?e*ۑnQInzt⭡Vs:?n i0jd/goB 9JץPŢ(((((((((((((((((((((((((((((## 1• A*j gÖhQൕZ9Y.nT1P$',qrx5,k{ыx"uY%v>]T'9?vQB9:ӴRmPKp I" |#$#'>⸍;X)]|2iS9<עbQȃO*\7yv(Wɗ=>]=ͼ-[# ob[!ٜ [y o1:)ʬw9?>zսgšn=й2=ĐHܻxqe $KicHU.$XDmFF:xGu R};q>LJ)`8-'jk[&;WʍLp`m$5Okmo_meXfKљ>o݂y#8l#q'y"_O ̂+ɑLcaXW>Fs[$-#Ԫ#ב6Y@00:ъ\Q<Š(EPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEP endstream endobj 321 0 obj << /Type /Annot /Subtype /Link /A 322 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 -113.8515 485.2500 238.6485 ] >> endobj 322 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/files/2016/11/table-4-HD-0003.jpg) >> endobj 323 0 obj << /Type /XObject /Subtype /Image /Width 600 /Height 470 /ColorSpace /DeviceRGB /Filter /DCTDecode /BitsPerComponent 8 /Length 55656>> stream JFIF``;CREATOR: gd-jpeg v1.0 (using IJG JPEG v80), quality = 82 C    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$X" }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?MF)%ݺ8 ~kkkMSS5^M"n-F.2A8vPNcmJ4kIH냺3 Ȳ+|  :'?ֿƏ]?gotO г _Mhj_'?Ƹψݷ􈥏Itt20 ھ&-i+Fc kikWkto C%ef$ѭ# A[g:BKTل`dPkikWh&兔6\涶'2 *G#=3o_?ֿƏ]?gotO г _MhjkWhw gD? :'?ֿƏ]?gotO е _MhjkWhw gD? :'?ֿƏ]?gotO е _MhjkWhw gD? :'?ֿƏ]?goO г _MhjkWhw kD? Z'?ֿƏ]?goO е _MhjkWhw kD? :'?Ɨ[O_\^/48B}2 8Z'>[L6X~Т{=&.; )6{_:G[t~G4 \^MipBmTTe!_9Sw۲hLڲYE[xLl6PNJA_V׆fƍئis^egvw%ޏ5\TQ5B pL<)'9 jkWi5zjRXko죾[4xV"  g'&3Fͽ%2tir0|9<W?t5&Ҵo ir x~_TRK(pM&7㐼܀3P HuItkWԞIn4"IqࢁFFz0 ]?(մ5p6>"=.=[K${[ yKɳkFq][_^/u? ڕ1&FB؋㑓2h_!Ssj?cpL㺸O1; ps &Ak[9o[}{i0{C.c~l>GJ`z_?ƗWO_^eZDvM{xDu!$!Ps2r G^yjjkWhw kD(? Z'3G[OkWi?5xҬiJY VӡjoGDuh5սG(Ӡ|\H=1@o?Ə]?y>_ i;]cIk89!O L[G <qٝ9`=[NkWiF_"ZE:d&m9 G1lgcU%]QHT[qLUE&<ŏLBt4ںZ=v m/N3Fd.mh#!w(*JŒrÜ:kex.-MgЬRPrtں_7[]'DtM;XTJre:O<:N$+2DEZ]+!uQ _ [N_^W4 Kh˛>.T+ZÚI8Kki(z`CLJ_ Ebi Z'7֗ %lg~=qOiZ?- 2Ťӯh2=3 ր ( ( (9׉1'?_>cqunf)$*rץXo}k+ǟ:UyE$i"tEs"mn'"^|#ӮV(u^ha[{-hKd8|)fk־gF8vWi]$"Ok-$zI,!IfȆ'.\sk00|=$|5Ku)RYEȈ*"6Ts\EQEs??׿!릮ggD=txR/e ۫Y„vF0?١brۨT4q G/<k=x&^X]ޢ-V&ٙ6X+p6zWD((aEPEPEPEPEPEPEPEPEP5C?Jִ3,5+:[y fy0Oҳ/(zui]&)5p8eAZjZm4NO#Js&PCف1Nվ.{IMr+}*BWHڠ/y<- //.u{7HUGb^u^m QUUyԒyb0Ln'XKPP03X&7-j}J-d#'p!ۊqK@nzLJ[JKgB(UR3$h>E/5 Zk),#{Cd]f)h|2ufy/O7 y۷ލ >MSöƠ B< /:+DS!A tR= ORDn,ѡ1f܅3oodZڸh&M1%F q])1@k坷#똲SꪤdM{0=8(g5cKknF{;mN7)#&< k/ i[ tFZŤ& 5xBvƻqU6>|Iw|7>lcۧbf~"U/"FA*2x`}iSj6w";;;TCo!Nc/n1]($%$(!WɈۤݼUc3O,!5CyZؤ/Iy`߀Aά1Tw~ϧcQ+8'..wG j1F)$‹ GmkVvR$1917t0ьwѼ!ϫM_WĶ[+1 !OVZ-0F)h9SJv5AֺZ(((|~%ğ&髙o}k(JZW)QE'4|Ls^臮N|W`kES(ERQL(((((((kR7Qі5C?Jh((((((((1l55YgKk((((((kTjtjP|?`CC ( ( (<BxiV^qv/hu Dyj pbHFpu\Su{YwVP\W3M,vʥ #9|11ylU/VAtVt\āNGj WxuƏmm͒o8VeM@a>8gV}~X"?C|i&,1ζQ >Em @8+oh(W-;mqqn YAC?0м5[P["'C%]ApcyuTVCI@zy4 J[]Œ /ٔ/nUyMz&4?&fΛƺ;i8xU11W< i75y%K74H0{vFS$|Ï~Z|<:cHIwT y)>]_k:Kfb"9TJ2qZ_i2Ɨ:|.6S?wxĺlZn,S=4 ޣ<]x`Gy嶮qB.OV߇寂t[z6KP`ݕs󻢩 sE=E4]oR[;ɞ߼i n9.@NJGkå<2sQh'N3F^^zܸM5ԃq8䄑ƹ4gy4w6׉ 1 1yڌ&IMY!rۛU,gUgF,꡺*$xĞ"it1LqqF2GQT wY/HXG#nqi;r>RsNj_]imA|uMBOC쎖;qc 9k{cxr 'P_H4nI0ȊPn ߍu S63 j?*v=9tx[X?r-ym閄xX:a/44sj{ͧ{U3. Ň&> 񳵦l&Yb[)Y@P˨)ׯB fOƩ|ϗ25^{.iSE1zs@b`b 8%x[:mNjkq޷a?i 22 X9v_?xk'U[xaͫx%Dq}G%BMOuKM ˓RյMNX%Pl= ~xw_?kU ZϏ25GOƫ9;_ Qx||5shkk'Ty: djZ(u>>w_?}J_軬?}.W̵ݓ?wJϏ25F%@n-+kkTy: djZ(u>>w_?Ϗ25GOƫ9;_ Qx||5szsIz7x||5<Ϗ.5]&sK@םOƨu>>tP5x||5s<Ϗ25]-y: dj;_ WKEyǎ$ҭ ş?tywSL>]X {R@_(u>>w_?Ϗ.5Gƫ9;_ Qx||5s3: \j;_ WKEs^w_?kU@םƨu>>tP DكL$\v]sZ;Pk(((g+DKAxRl"Y]'$z('$7}ľğ&<] r_FUIlnѣڤL7dž w5/pGi%N5ognӼ XmF ;s־&=`$&H<v=^yyzDtf鵋a[jTʍd9G4[ZxIVړ\,b;q`zI(.iJyOcޢ:֗4QU4r 3\&ޑ=ڙ$-E(-Qw\s1Y\Y.'jKƞPQ.eWn+q`C :b5_ i:wWւY]Č\iȭ 8+HcFQCPqڧF*"*G(K\|8_?CHP>&:P=zA‰ЇlJvh7aQFÜ杚2(>qNcL\l*j66^(<"kycs>ϕl+Mt87$0G/xR,m ˧٤'sG!S> 3-o׵:oFH}B"_=3o`I=EZLKՉ[$e]Aϟ&mV-1#e-?hh /ݼGzu5+]Z(bkh%1ϙ*$:]y vo0K;N|0q^-Ň-rJ 62! |px5\6%ׇ͌C]Zhh-˅Y>yvv&vf<=&٭tX%^8Z8QHPoDO%,JZs_<z??y/e@qڌ4/ΩݱD vC A$ij:+,㎙7?'>+=zw=F)=y-;k)xEXZOe'I6[yּNց>L߻Y>_n>FVOZ[wIfXog2ʋ!tO/f䌝ǡ־^rx{ nY}ěy rۻqCAxmJ : Kq5^c=z$6=qk+mN ROmrѸ6ǧ܏j؃E񭎿gä46 gwG[F]եյ㼒ՃȒ!Hl3 3ކ!!ޅj6)?o-f}>-!`\={WUZƧb2ŖnYա;˵2pEd [Lr2},6 nXn-}GNhڥS $tx. [\J .96.f'55b5U%޹Y|O;_G-OsJHݏu\W zayՕe[QԻ|#f qҹ?.Oqhu^0ĘSZWC^.4K{oxMfa%>ª$tony3COcr `B0[EGI-cGI&h+E#A6ÜW<;WOlZܖZn A12>fU`rwdBt+-P|K|Y=/":>%,8u1":>%,Du?|K|Y5tP5Cω/FO_]-#_GSĿŗ#WKEs_<j?y/e@":>%,Du?|K|Y5tP5Cω/FO_]-:އYOa)K=ɉ-xFr9y/ej_P?2ҺZy/e#_9Du?|K|Y5<jhkO_H|%|K|Y5t՝iϩƑ}couVocxf,B5Ѱ[vm6qooj.(¥!Ln|nO ojqjqm"=IE|nHcqz[ص}> k aV`V@213ޛnfž(ӭ3`Kʾm~cT}[x?n͆J} ϩZV[&!O #g 1"vrX\PZZ}%Ԭof y\uI |ݨ[%,D?|K|Y5tӨ#_GSĿŗ#WKEs_<j?y/e@s j0l2 tF-#99dWACω/F1l5P7Cω/GO_]-#_?y/e@":>%,O_].k^ӯegk%« ?<jODuO|K|Y=tqȒƲ#Fޟ@":>%,DuO|K|Y=tP3Cω/GO_]5G]iCsjz}:xۧuJk?ڇk]-QEQEQEsbO I}=.Qdkd-1I>BK(v@Q@xNU^’NԬ¾[ɿ&Nr@_?go{u 9H>^HZ|KX$rd-RXe}k2_WSL}Nq,b/8$ޱ gsK/í\O~ߪŪK0$#=8"|;u0 Ae"exA2F ,Eqn6kgfRs s ~Zu-MiH1Dc$lqZ|/=~5^nmјǴyIwAݝCJ~YZ6{2drncu%#8BϨ>ϹOgoD=tM8s臮pJEp= @.&F@ &R JLJZ(QIF@ E&4nRd2(h@ pZ7ZZ)3K@Q@֧%@n-+gS |C?J(LZLQK@)0=($ M@ F4:M֍րJZ( k/ i[ txk!Q/KaPE%-fSF;KIzn)2(hh9SJv3 ;PkJZ((?wT-ޫPt3]YG+ERq\ 0̛^mXŋh.~6pǭzgğ& o=skiaxn,hv)`JtGzC9ejbф2\5_&:t{Ad2fvnxlj)4W<ʠ#[ s OVvߵiΪcvlnIlg&ᬲxx|xiZ6kt@聈FO8մi6:.&F1#-y8Ox ڟ4rk#Y,FNQwfzw2$`RU ˸AֺhhZPm"XVYUBO?Yx &V^3_,4f9V^3_,L k<ÿ6EЫ#X\9 /xm J`8gD=t3${7]y\ޓ~ K5)%%.ݣP]H8$ގGq}B #:]\HdRv5uV$c{KwdDb2(Z,I-Ƶy.BEx@Gqp9to˫FR /ڥ߇%#XE&mEHWH (Ous+ ߟJ ῃ,G-&[ERCuXU1wrluk ԮYiigҭ#EbpI9 A[}~ [_21dH#jjjVrWחQuDW0`W:橁 oq$O8ø5K5+k`#Hȡ6JN{g֘:4_kOZ 퀑VGnC`drj3ּ9weM8.hvC 2" T㌂+]qmjޙׁ>Q$WڪtE 8x4|s4ѕwqNY YРt`<ݜ` Ggw!CmuFD#,q85q[no^i;o qU-Czη>#Ks-ַI$!ep2zLEO??k<%ӯqkzM*?1'U.~hZ 4$m-&GVm ݄q9Taer@ai00-/`aaumS[iV.<m`r$tG@wWzxchi>n v\9f[6v_g-j"G1(E`w)UԞin7DHd5ˍt. /~dM/+/ЙAH4Yx &V^3_,C߃ǚ%K}kBkF76=2}keo<5?5/(zui]-s_ BgYG+/ЙAKEs_ BgYM? < :3_,t#Σ]iQ?[Y^)} ]Apn烐1Vu x'Gh t@H &M~c'隧hxrmF[]̨a = b :յ\H0Yz~T'rM]vx*·Z;fA8.]ۉ ٸc'֏ +jxK2#Y#I.eqא hsZX1[DsWҼ/6񭾗o 6H';.(8~P^ѯP }au$6ioÆ@w 瓑]|="׭t kEXs>2āy5?. rڔ7ऑ1r0_JKdYZOi<_|9x7ŤK[t'=jGʹ'/V%ip/99 z o/=O4l43go5_V^3_,Yx &V^3_,|;mhLڮ)BVYN;?cxk? 1l5P4~ &uMΩ?t)],]lg78&jVږ i% lr@g/G¶)oh6|UnAXe'^g#gTZC^IS/A'LMw5eZTȸwQgT=]K譣S#?VbsHl/ .#\wb7:q]"ؗ|| 0#pj,$Zx4Kp`=G=kֶzr)³7 dM/+?ЙAKEp[A=mLm:HlR=q]sZ;Pk(J)hg]x蘫 o%kQ[&pǨ",C)ul#nF3UX494KO}"LUF fr2nz?[coM@lPx>soL5jַ᷆fXnQ]F̫ 2A&׊??KiqB_r:+u_r;I~"Q\&w)E*KZ"F(w2@2@PYEs#wSćE)?4Sğ/9@=ip9>?_r|gq0K3xo_YE.@y nj?T'PMErXQ"DQ; “C %X'4\&w)E)?4S/9@=qRgqB?_r騮g;I~"㔿Ч_KEs_Х_+K~"\&w)xE(/߈tW5 ^%?3KĿ/9@%@n-+8|[;xDxg|Y-͙-r@: sЧ_3KĿ/9G&w)xE('7W8|eqB?_r+I~"l8k+2_rL?S'PMEs?ЩOiqB?"Q\&w*?/9I TPQEr1@mxw]xeX(s㊖?K2,_NVXb!u4W3 ~%_L?R/PKEs_Х_;K~"x@_k jsHby ΧWB}o<:ag_&H1^t]8G{ids+"(9A{>;žж$'pɥ2Kml]6n4Qjj!y r]5f_iͭ}$aUxRL2 Ҷ:){si+L6aj[M K3L뼨U|9֘?B[VO_Acqbfte~-@ONf' Z YZu*.`0;^RAn#$F8`28$~55m ͑$n htvk}SQY8UW HVaI$UN=O5έU;cm%H4-.'Fkn9:J&Jdu@\7{JEO\mQ-#)UyF?Mn7Z~%#eă#h]8̋^B1$ ;}_‹0))Qe0 YB gc8O M/ i:e<0#y~Sr LkF#V1TI-f]#Oӿ,?fM7q}F2JԔ bAEP0(( etj_P?2ҺZ(*938T-q"jz̉s] 1@=«ʒB=9:>*fѴk}L\ʶZɴ72`QjլPkdmE9~溛x|#s> IԦ1[;^w»/r{cRx),tc]|XȎ);GcGORMvU z[%:uv񿘐*99r:Rdo3Y^G,%E#k' ºEm,qWڳՋ\  &L矗WheĆEU£l^gݧ}QՈ}5mnyƙZ?s1JnP!~n00W_o '=Ov"gc4orX=X'D)hQEQExĚ_](\׏ ea/KajwW.'nVP>]UpH$Id+?TQ0FAyxM&43KS4P}H[1&9mŽ=FqXO}?bmic?i݌w۟j|>˙?,$8'\ 9qKgs#UԯK{m̌Јlp4D;#kw._i(9 ½==SMNnU4E[MXT _񦈱xR'jio@-X3dGp0{Yz}[kTuխmcvʊ7pzY#""Q#V3% Vlu>Cgce.#dXr >\cҵ~:ݲj7@K@<ݹZ)i(?ڇk]-sZ;Pk(((g_ Ia߉1'j((((~&>*].Es_qu/P]x &x:R5,v}~PWFGyT6zu߇y <̑} ;GIdQ\,l缚?,;` (RIS$cIeKBH 1;=hpc?SdƱ!yQTdI0w 2+ѼKv[ЁkY|ոON29?3?Rȣ"=/Ş"u-GLÏ{2.ch (#FA4xXox!Gy8< s;w矆€:lњxk(ώIFkώ>:熿€S#?2Һ\ל?wnO0mǙk:熿€:>zZL9 O7@>Esg?矆³"OHo )}KA*@9"Ek*$13xv)0[Ts8-:熿€:L\|u s<5}?#cK?; t^uLlںv64v3W@@ I?Z3xk) x ?PF>0$~ <g?R>ErhQxeff`I_0lPl22AЎж;2+[MkM7]>,@A@'DWѦfҲ^æ$wYdzטi_H|75O&OF3F;AO ľ/S$ptg?PH"5sKs_@ 0tG D]0/u6ww4QEQEQE7>Ka?L5W3/$0M@Q@Q@Q@Q@'>+=zݼ`VY""4.;(?@+ gD=tE&麦>j:ŝo ӥM:i\ΛwI!v0RDEozRW>D lR ;q $`k6GMv->X$lw7p Yf6į7J^k8|S -!Bi)p8s9{ז.@x:nk^#ko7KUJ WH]=_ښ:q 7Fx\$0$ +l>Q^h~jmu TmAOӴ-&mlmW?xͧbԬ,|OrbK+ŌRY9rgxX׾lsZ[9h! 3`QMh]3>"kY!Y-JȌx'b kMe|O ZBujA%[|g/(QG=<0 ;;_Eqxۀi}` g|6m̐M-VIE|4pEzY@h=(S'֮t+/6~FXß'v/}0O#ZҼXj 840oGG=(ؾ'+}f:0OwmEխ@4x+[kyea{uy)f#R1o(x#/2 WSڂ{S<q\CTŤWZ3N%.cP'#-pjݞ+mY{׾ѭӧ7o#ݳ|s`_LשI KF* EaZiii }i麌^m/~K@Q@Q@Q@σĿD]5s> bO tQEQEQEQEMs臮uO{ π4ŷ>%ws88ݵP=ޡO-孆snRRzuo:k ;lILǖOxhj+.eǥϪx.]!mH0elGD-IovbpI{R P'#$æ z)kˤy ψRYLhY\jtOIa-j>(x[2.͡?) R H+4/L|a>um"kwL1 fWU]S6 Ljq\9.@8z.;ޖMV-7G:QG'4i fHLb2Ai}b4$R+b&8 x0=&-GeXDBUwȷpTʂ6s@~lNuC"؛Lh3>:j"r\ VꚘ !] 7/*s =_騮k=A=G+{z:Z+}R¾羿=@5k=A=G+{z:Z+}Q E _h>ԟ_P_P?2ҺZ}GJxDM}>:lc N@8騮k=A=G+{z:Z+}Q E ƗI^s6UG6ItkApy+\s>=@5̟.?>GX𷆴6}Fim5JzI 'O4RWxg]i+#GkwS3~֞[hSǾn/!>vހ=e. /+Kux_O/mbMb=JBo ڐEyipxDUY1kcRQpOTЌrW$gw-ީo?58'2҅t 1Z֊ CZz;({W:~@~Q)e'r+Wn/4ˍL43lH[<m8r1)]W/}}Ǩ}}zTjt- ֒j.eӯ}Pt]׷Z (-Q@σĿD]5s> bO tQEQE&hh(~&9W?Cs=n蒕!r$_]-&i|UcӡhNM5ĄIA&c@vj kZ+;'½;P Cڕ}N^_AOjmϙŰn FI j J-Bjri-b$e QE\[υKrK,Ɵi9`1s 9> Wu׬Wܺ%b% AG#ҽ ߇ 6kZL]0G#V$>!bAi5FnDb0I>o]`LOvMs^me iW'4_4+tb~ҵ^;K.RX>S5 gkc7fI$tzey[piij5X-e[^Ē8`8%\QxwD%ꚞxmYLHl( WM1J9xvZ(M$H!hcI5Ў(Q@Q@׏ ea/Ka_]%k񕘿Җd$3rvxՃ ኅ$g~&C82P][[8m 1fVNAA25|ټ6>~3"lnzoVE;)1ɧ}?Qh;AA=W#Q{#۠ EAgA#o ]KBL S/wv?мsa)yx\ӓD.un Vsiu 1c@n`RZr^JZ(9SJv5AֺZ()(h4/xgB$%ޛgu[CCr۪ۻJXbQ†<W ,gxlN*ot 3BűxZ]ZYUd{|(NN*,۵S^,fL.lSgos ⩧wnj7875+2KKkyH_+L/"? sĝ[R`ѡK+6m$јV?=ʸ,Q 7:xopUk㫸x}2+' tN<m"5ߋCe9 +E=gm H{,Q 7:xkpUѩ&@q'o<[ko~yҮ8Y,6I>yӃ$G!z3-e :2ݕo78cG? *~kWx:֣u|K,KFaj|V%o5toH,a*3-L |/ R7~?UdEj>+.f-UX3ђ˂\z5W&éEͨF3QF'<1xpQ(C;g \wO|/[Fyl:.[BVbx~pdR$A$t\_<58?C7g? Vo~#ojo?zиO .:^Yڭ?UG;ȵcFl$q6 ȹ =Yrwy5ztpL(*b27x@'sSo?q f6?'Y^Ե8[;B[-u,ɷ0IU!15܎/U| Cg]-/U| Cg]-8ۭ*;~f]WNX[Y I=57U/IcK; t`b9Y3ot ⫥Ry8@,Q 7:xopT xĖ2_MF)tрw3ei?h,xdy'Pk/ Q 79xopU|oV!:)h* \QxfP[BmE#'n.X2 er=wgpT|?U|xlN* {Uu]WWmbf?`X3pkiLv*:l#",Q 7:xkpUQ@?h>!.際C_s8?wU.vIK@RPIEs>ğ&x;E]V++Ũ@IՉ^bO r~'TZm.{k nZ] $ $^w $2c4CroĐGqӆv\g+В}jѭ]V##\ټm0G8MqI֧Hi!ҴJ4x$idtb$qCbfLK]Djy-|+(,fX $(AfmO]-"+KHi*\E<@ȥF $~5_oͅɩ$VsW,YzsH4"KRBdO3hY -xE )@ zAKb"$u3V:i qZ$[V!!X'>um􉕖-RiB` @N:b;5oF돲З__l8OPf(--H !iʎW=H@I9^9KK/kV~j(_B_+_?G%%Q@qͤ"Uӛ.-Hq$gk/DV~ƗIڀ9KK/kV~ZegXf/sCxg?+_?G&7&x%%携v H$_C1 e)c޳tZwo52|h4rH LoC3zgzOMne~E~⸄oV[[Ѫɧ<@!N#*p*O YAy6}D4?n(=/[^#bք+')9^ 'Y#6=A\RDεVx_% $:zF t|b24$ } ~%З_ME08XWzN yX|M7O|Wu\֩%?;Zh( JZ((9߉1'j|~%ğ&(((($]FpAEs?׿!릠 PhuL6U2FW:*F4<,e(L.=NV6? `!AӡȦ/H4rA+Vv15=[*,tڤ cԧCXۓahMaS|^JGy$%fO#">ͺ[.]c:mV=3ZTP|g(,dV${t"0zg*mA"UxUeS+F Y b,2K;xcHl | | ( ( ( ( ( (9KJ`GFZWK\֥%@n-+((9ՖEWVdR4(_#²)W RQ@,a(#H`Ʊ(X1(ҬJ--_{5ncYsaaih_0Bv5x QEQEQEs^?54-J k/ i[ t#YchC+ aG@ HsޝE0 j6[Ggl3o1il$cjW6]m+0NY᷆)f ZCuj(O(>vK\֩%?;Zh(((o}kg_ Ia ( ( ( (9-׊A?K&Q/4/Q'r$[J BF6ӵCIxV7>'LhMW7TKUޮa7߆3.mj|}=~pu?R;Oc>suֲnBn%-r09$OiMNhnIN6OL(5Aҧ.ˋibʍ*Rq$dVeoc|AshȼXn"H%"u 6 Yutc̻FN>nGIe|B\!1~`rUKrt?6Z {}<) AmV'$ d4 G\Xf̒%|勞Y#׌4 7E|UCt_,O*JZ濱|UCt_,O*_ 濱|UCt_,O*_ 濱|UCt_,O*_ 濱|UCt_,O*_ 濱|UCt_,O*_ 濱|UCt_,O*_ 濱|UCt_,O*_ GI0戍S9>Q#t_ؾ+?5?(zui]-s_ؾ*/'G/nWKEs_ؾ+/'G/nWKEri>)YcӼL"taۥ$$ 5HF#jivaj_oWl^YhHXFwdhMr)KKikY/Z}>]>h#A4˺caNsIAS@sؾ*/'G/nWKE9_ _7E⫥<Oҭ (UӀNE8?{|bt_,O*ƗK@'nR` twl2-F9-|Aèk-Aevv`n+*cᵾ_ժ4͸ҭ%#?4qM-YonI鐙$E\bkLz3$t\wp}A>!5 }CHմ95MnUF 28~K@Q@Q@Q@σĿD]5s> bO tQEQEQEQEMs^臮-׊yPx-4UYnRKXxIZ0]~Y4(,SFhh-=)Î(SK֔0#Z).@ E&h-h-,S@p"L3@ޥ%@n-+gSa @ui]5QEQERfIBuQM=E EPEP5YcKkkA05JZ)3FhhQuJZO(>vK\ΨG,?Pk(((g_ Ia߉1'j((((~&9_?KW>maddRV3ڗgD=o"$7e*vZL#k6{: cy. fe2݂Np:95OoY-DS.eE єp}G#"_|'\}_WK[[&I7;%JAA,^9tt;y4$F1G34{*zrsKMƯ _KPPe%t!rAi]9K"\ܽjaꥌe3XpjM/ᆻZAQwҢ 9ԓ&cӎ1Ϩ 51 >![꭪\( $ ;65c;X< [Cf"o罂eeN u y^OW8^AVrDAMTcVE~"Ec+ y]w}+cLf]Y떠;{K{(?Oxڒ9ƑkjCO?hԯK))Y~{V߈Nnu[eu71cɫ f5Gn5ŃMJUrzsT_{c_:M֣h Y2 L,Ԇ fJ^{h[HQnB;1m{keaAo692y!a=^z׈-u}rDHi䅵ۇ(w⢲}MծfWK#iahF8$a)2 nFV[vPA$9p ߅; iuy-yjjyw? }E.-ͦ*8 )P@pH$kfOj/ Z)72x(J  8Fx/v;yPH4gt{O#^X#}]߈X0|1$䓀 [̷ڳ{V,m5Wy .2` ~u>TQ[X۰h^P 5).Sf=Gڛd]r2xc[Cᮥ Mk{H8?hԁu *2ElZUI5=ไi- r \yk~nyƇO-eMck5xRd…3] GmOr6SDHpr# Ú힟d\\cO7h\<ⴴυmd-FT?[ہ}q_e|]j8Y'Glmf8 PN  N{KSVYQ)%d0b@,"j }Ia$ݧ3{i_ vOV? /~ڷ+ۮp%m"7 `q=iį/ø'ySbM*$-m,arY$Y.q/d ~_z~]5m΅  D[j$GVJQ>g@=5/uy4-뗞Q1ߜvz Q1023&č" z?*mVI,4I8mAZQ<#\GQLO:y~˳6^CV,unɵZwIx7CՍ0CybHzǁB+ib[70FG|1jA} VFh`˺\)T4S3iWZ5ݻ[!\0+4CHGеmX,]Fgɀ \}'B=]ܓet29/Fh=GԒy$6W>Gc^) q]?+wT;O^j76:O:KksD 9$s_?SvW~k;]-%pkNо!b.N M?G ğOjb:]jW7 H?=?`_'1@!QsG 2zG/, |K)\hJ] F_x'{P4/ڇhhgd&q=gDR?ĿNbIGj]XG CQ H?=`tEEs'Ā|=s)`i_'1@.Fќ⹯X:? CR7-A-i@$jb:]KzW5 GO=?`_'1@.F\,|K(ϟ?tAF\, #|K(ϟ?teKzW7 H?;?`i_'u1@QFĿNbXG CP ԿxQΖ;' }7^ۢrG$ 3G #_'u1@Κ`i_'u1G, #|K(X? CQ H?;i6`_'u1G,#|K(#=kϟ?t'ڇhhk>~$wP?ğOjb0X? CQ G?;`tW5 H?;?`i_'u1@-?ĿNbXG CPYcKk9ǎt*R?4[I~%wP?ğNb:jBk>~$wP?ğOjb:M+ϟ?t'ڇ)kϟ?/, #|K(XG CQ G?;5O(>vK\,^">!kN$iQwtWu@Q@Q@Q@σĿD]5s> bO tQEQEQEQELs臭RXGBpG氾&9_?CAqmRC2E*zje{R $Rq!NvArNpUύƴtcF{tњ3~ 4'[ A“ӹl =cKm%U5^`r~,mm&HHUX ߌ<@ܲE{YcvO1rdpҹlg/ 0\hpo#*ࣿa{ҏxhZZCp$6})h~v][yr(eHة^#Q᜜ -+B D\ai|7[6d`]&wn4!M{]p{~${ 2`u{_YX8!NSGڬCrj:|k;MۭWۺcu5 ^5܉i! ׮8WݒKm巆h& ;$?$W-ۤ.41PpK,c^o%/mekk_?&^I…ݳfG~vKn.me3CsA _VV|ա|;o]hm{`>II99_ΆrxXG`^i˔}®zqңyntiZb.3X<{b 䎽e׀<5},RRHrڟso^\^\\h-ꔸbÿ!k^{t˛m*+f0|\,,+GRW48uq7vҤ2[$~c,0yFz>xX,dDs96ؑ,6&,FIw ?i?l1 $T0Z((/(zui]-sZ= ( (M;[/^Ci6w>T $?`rx'u^ @%]F 1<_n- N_\H+~?io2Z_4q嗄,[ WfzUWE-Mk$ GqI[CVL9bYHFTr}Y}vW,帺u@gdyBVe=8+GH;hѡȏhHirpVYM'B9 -}Dk<-74w6o*I/F+.G^kuv$0Uc ( (9_]%s~?54-NPW5)4e<.@TNO~Rd[-Uا [v+r |Rh*# TȥG4cZ楪 kL;ӟ+;x^f.l[[$I:#$eOvZ B[[h%]d0"9Iic~3rb1]I8faϥdC>Lޗٵ̅H+eommoc QZ ~Ӛ=ơs s@\|xҰ?̚cYC M\xGY$팂A]l[@5zLbEjP|?`CCSJvIKEQE%P3/$0M\σĿD]5QEQEQEQEs??!릮gauDG>X^y9 )gwX*2I>Gu4WXWRxFFEgbz9ɭx̱ݿ :qJN+>V2B\wmR@^m~FwtSx]UHIj3Fq,:_#$ sJ%oCˤx}5 ku`FHZ>so(zqK\xWhNSU3#2Ɠj>+hYG[(&+?H{ 'o."F8'К L2un|E;y.n<= KIZ!PzqH ']޽8`1]-B$b=p!5>U0 o黧cIu)bf\a#׿Jb;+ OQ?7gHEoW+?8o1GWpb:Z+ OQ?7濵|gBj}' (_Яھ3_I5/(zui]-yƣDf&]>* Ue2Zq9=1E"?Wpb:Z+ OQ?7濵|gBj}' (xd1 '>ڲx|)6vf4xV[ El=i:E1}j}' ( OPAֺZᢼ!VҬUt,zgwg9qֻ(((|~%ğ&髙o}k((((ghϊy⸉k)Es?ן!릠$[&Ծ$*M$RF"YYZ;up'^s6Ʊs{<1^I,ϙ`FK7|(q@ҧ[!pv#񭿉{iidkz|(S^#=Y&)Gj> ?k3BD;+4H !r,GcbO9 ֩g{!/,olerca`2E}(]|PCF%̿i|}1R^ uJ;kYYȉnpnOjlJ4{]r~pz^'V 6gԱxTyͩVke#b8ܩ89 =#Snmxhg yny2tK`Sk=$ùI%GؖcIh`zQ$x楫X>ͭleu~?+wiQ^_mOY#r~u V@Q Q@d2ѬҦ&=Ö>(I7KK-~j:uȷx.>YR`UVC{w@p)0=)‹aF(|~5ƗJ@_(j2i3vgvf<k:j ymf6Iݬ/@L3ܮ-M$}k`j@yb>!x5{[Xt@O88J1WϠj5cei=Gz4ئyy8fX\oviEa⣒]3$jB-SD Uʙ~gq"hv~-".qQJg(t,ZJZ(\?PkkTjtQEQEQE4IaZ$<muy1+k* 8EqZ潦>4ƻ罽Pu@^vwѤլKkx Ov(OLh$]5pZ׆YO \DjԌ2c`E^1Օo0팾 C0UX`p9OȣjZ&a}<-.b. ;{ 4R+%(*O|KKPKEs_ICO)? R\!R_ _"BĿEtW5T4?i//@-' >%(*O|KKPKEs_ICO)? R\!R_ _"BĿEJkK} Mqorʫ,>rUBĿEtW5T4?i//@-' >%(*O|KKPKEs_ICO)? R\!R_ _"BĿEtW5T4?i//@-' >%(*O|KKPKEs_ICO)? R\!R_ _"BĿE?#_] \+xdIcC]OV>(&騮k?i//G!R_ _":Z+*O|KKQ\4x R' >%(BĿEICO)hk?i//G!r_ _":Z+*O|KKQT4T?p|?`CC7jjꚵ0k:BG'_ʺ*(((C]yw{RL򢂣I>G'ҵI[Uuu ^6XwrDrr r=4uLR}A267(F(]Űr\c#RX$/5 篗 *sˌpUG KBXm**O5OOn,\M2ծ-d;F $.MUC`tX7׀aϽz8 vZTtUIcRFBF8nc๣GBcsxyPx-OZG &DvRH  9!4s$@ZvG>ac;5iWWTm6T ټsxCInqg|`~u ZfBUJX^9t>iVbQhn$ ۥq=-l,|7e[K]FcF1#s/pk~H$)dLJ8;I!J>pH $`fky5EH!fs 9hr9@c@?8Y&iZMsTtUBUŰzUmGž#mSOɭ ;P;1ʎ0O'߃_糞b9m\,R! / q׾#ڶמ8nep)DܣvCp([}~Y}jcOҤL4kd1 ?tAzqY=oKK /a_&t4<0'3Sz%W7E$DX *0%A*?X{{ztvP݈H1|npp}EcSur-CQHY[x5L»`gRUtYcz:*c,QEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQEQE%-Q@Q@Q@Q@Q@Q@Q@Q@ W;Ee$@/}ZpWxgsdYJ-.zcMź4υ"H-件{ey@˷8 eo4>m4/llR9KռEQ_:m6=ʳ4+I+p[8 FG\ǚƙ}- i7dn$ gך, ]+iFjzOF:9;O_/mצo y.l[l&!HU ?+EN!(h+ZF*sp}+ҼmO,CV4B6iBixw][Eyi#te)aFA+WF/j[YcTU*1NpO4xkk{wmmH[Ay",zP=OXZ{ǷcjߓFgKƱmʛYD$'f uM= ֶPIo BO#ڵnX=ϊZ5ޫ]ims$v`@TghH6zcW(?VB?ԷTyܧc 0PpzVgx88,W;:+:\oeVsFBG2: q1Z~<YRW^+մjGo㸰)OXMWq7WVQs-|Jd$d89Q\>,6| i&IS4qvi_5[]iRğ,Mi9q ^g^&🃵: ^6}qzeBYY-Il BȨD>^]]KW𮏧oxڄ2[`~w gXƍ hk7^@dbDnJ): y {@yEylj|mu7?GmD[ ^;K۔HŻbNѬU!\rjL[M$%h<4= |MÖZwqcs,` х,8OkW6kF5f$w 3<1'@#wVK,Y:|rC$yH7 @0:qS|_cҵ8 0d'pg^NA⋃;+妗<ֳ[m@B^ۆSN7ڍi]ٍ[PR dX' >Q;CPq*XƖYE++=0z}EnvX4d^[Gqՙ$FyWLK9p#ɑX1`[;ko7%4:ԙ"#<4/&1S-@;PTioq 6CzLGeR‚h!~a i}6^ q"+̄G$}ɬ-;ᅶ+o"[e%N" ēS1 MKVji{qXtc6W[p{/u}Bյoqe_\l,ovr0#pxwmx6Vm}BJ "uudaFW 1VZvzw5^E,Y|,zlN+_~ "ю RiwBeC P˝z}E{?jnGzz۾wzRK`rA$׊Y5[;[" cTmRL ݒ0@Co%3\i3^H$W |Hm 6L3^Gk$P2K85Pw-M mJu+6݌iw ͻ,&P#45: NKi-u]CJ{x%dN6 qMcA84M>=:U IH'1M|YNm{#uSK庽n!CN} ζopϩɨC#jʩ(9Xs;մwB-g>oƥZynhSʓ`կu]C2zvP",8$r1cm%KQw]IDXy49sFlKmO]:H#t Ώ`X@'4pϯCu]<@f`j 7K}\KH<` ycާ$[ i4yV2Z6sJ5sGkX_53$s }g;ݶqcb I5;WԴ{\_]dG 88f;[߆V 2MImqIDҪڪB hڙ.Jb2grt|x Sm5^Α˩cĒI=}+JPZZ^VY;ټB+湫iዝRR0}MS,m(bIv$=Tu #@u$MCSGJ͝ @1M7Aw7c';7ܱa%!~[ y9~@|O;k8b?f+ Sczsqqa}6I5i.De&C8Rj}7i\:Mop.夝tҢ>Hq=ih]F&$9VWye0$@`:G?aQsLР F2TYm;VS/>$}&{G@[v~//.l-&,c1Fz0TF29pٖplcs L:A V Hfp96Ӭ4մSE\)$ۙH,I'zW{CY ,eZkj;'b5x$+bTW|w(=Ër!L6:$>n X1tm5}[vلúxaY= 2p¯hFeћRoLjٍ3Jb8tz};ȏ]mg5(Y6v.eW㎝sZ/6}WUV˽# /+iP9#=I5@30mNn- `hT\ܤ) ּoj͵a]&爜n+#.y\KEq6 -$ӝ5Y{f?ҥ;G0H6oU7vfym2ce@X+~X njYTt򼽸v?s9^gaS]m[T[ y8AM\k8=u[|6x-SS!)ueA!'1xnQ9qjZxY~ar溚)XgT\sw ͣ!vG++$b';X>K#-_'baqkr3>Q5oP$1*B]P'89̚yWO%Qq]):7ud^\$hĺ[6Bې*)X&ԓ] +|1f=4ET3dj?  )E]Oios 0֪$>O\n=zmX5ûe67"-LP(8|&ӎq_X#cl?aN"&2pW11]?{~{%QDr_-v#Su7"מx%YQ1@E!~_<=7uqW[: UE Dx@[y??Z) G u@@gL9, $3B6ߝ}Q@ n/{DL2[hlF2A ixY>%eG'i%B1*$`GZ(WzWI. +$mq)iC>͜ӊq×Ɵ,Vh \D8ݜF R{؉>n;fl Ӌlx)] A 5* y1/[""$z (fkAMZmB"h7`cJui=I*̎i"bQ+x<(QZcb4tFD+'g7Ÿ 4R/*,lp6+nU<8QK#N?kZP,FYwmb }W>Ү5`t1(@OQ6S-ZjX$w1FY}۸ldE$#5xM/- FV+SJ𦗣A{oe %$،H?B(2~#lO /o2nAe t>*~^z`bE)*6[Py `OwO߽\7%ĸE} ?KOz%l646'rlI (ռk-sYpeDŽ4uWK0vY#mcq3EH|7],% ,k> endobj 325 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/files/2016/11/table-3-HD-0003.jpg) >> endobj 326 0 obj << /Type /Annot /Subtype /Link /A 327 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 -113.8515 485.2500 238.6485 ] >> endobj 327 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/files/2016/11/table-4-HD-0003.jpg) >> endobj 328 0 obj << /Type /Annot /Subtype /Link /A 329 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 373.3132 485.2500 670.3132 ] >> endobj 329 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/files/2016/11/table-3-HD-0003.jpg) >> endobj 330 0 obj << /Type /Annot /Subtype /Link /A 331 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 -113.8515 485.2500 238.6485 ] >> endobj 331 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/files/2016/11/table-4-HD-0003.jpg) >> endobj 332 0 obj << /Type /Page /Parent 3 0 R /Annots [ 334 0 R 337 0 R 339 0 R 341 0 R 343 0 R 345 0 R 347 0 R 349 0 R 351 0 R 353 0 R 355 0 R 357 0 R 359 0 R 361 0 R 363 0 R 365 0 R 367 0 R 369 0 R 371 0 R 373 0 R 375 0 R 377 0 R 379 0 R 381 0 R 383 0 R 385 0 R 387 0 R 389 0 R 391 0 R 393 0 R ] /Contents 333 0 R >> endobj 333 0 obj << /Length 21261 >> stream q 15.000 33.247 577.500 743.753 re W n 0.965 0.965 0.965 rg 26.250 730.777 555.000 46.223 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 730.777 m 581.250 730.777 l 581.250 731.527 l 26.250 731.527 l f q 35.250 742.027 537.000 34.973 re W n 0.271 0.267 0.267 rg BT 35.250 766.011 Td /F4 9.8 Tf [(Table 4.)] TJ ET BT 71.559 766.011 Td /F1 9.8 Tf [( Correlations between SCL-90-R GSI score, UHDRS TMS and test of executive functions, social cognition. )] TJ ET BT 35.250 752.275 Td /F1 9.8 Tf [(Results shown as Pearsons r \(r\) or Spearmans Rho \(rs\).)] TJ ET Q BT 26.250 713.754 Td /F1 9.8 Tf [(Table 5 shows the result from the stepwise linear regression analysis. We found that the correlation between score on SCL-90-)] TJ ET BT 26.250 701.849 Td /F1 9.8 Tf [(R GSI and RME, EET and SI-M score remained significant after including performances on all of the executive function tests )] TJ ET BT 26.250 689.944 Td /F1 9.8 Tf [(\(Lexical fluency, Semantic fluency, Lexical alternating fluency, Semantic/lexical alternating fluency, Stroop test and TMT B\), age )] TJ ET BT 26.250 678.039 Td /F1 9.8 Tf [(and UHDRS-TMS in the analysis. We also found a significant negative effect of age on SCL-90-R GSI score.)] TJ ET 0.965 0.965 0.965 rg 26.250 402.422 555.000 265.736 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 668.158 m 581.250 668.158 l 581.250 667.408 l 26.250 667.408 l f 26.250 402.422 m 581.250 402.422 l 581.250 403.172 l 26.250 403.172 l f q 450.000 0 0 217.500 35.250 440.908 cm /I7 Do Q q 35.250 413.672 537.000 21.236 re W n 0.271 0.267 0.267 rg BT 35.250 423.919 Td /F4 9.8 Tf [(Table 5.)] TJ ET BT 71.559 423.919 Td /F1 9.8 Tf [( Stepwise linear regression results)] TJ ET Q BT 26.250 368.201 Td /F4 12.0 Tf [(Discussion)] TJ ET BT 26.250 348.246 Td /F1 9.8 Tf [(This study investigated whether performances on tests of social cognition and executive functions were associated with )] TJ ET BT 26.250 336.342 Td /F1 9.8 Tf [(perceived psychological distress in a group of HD patients. Since greater degree of psychiatric symptoms such as depression )] TJ ET BT 26.250 324.437 Td /F1 9.8 Tf [(has been negatively associated with both social cognitive skills and executive functions, we were surprised that more perceived )] TJ ET BT 26.250 312.532 Td /F1 9.8 Tf [(psychological distress was significantly associated with better performances on social cognitive tests and that less perceived )] TJ ET BT 26.250 300.627 Td /F1 9.8 Tf [(psychological distress was associated with worse performance on social cognitive tests. The correlations between psychological )] TJ ET BT 26.250 288.723 Td /F1 9.8 Tf [(distress and tests of executive functions were non-significant. Furthermore, the correlations between self-reported psychological )] TJ ET BT 26.250 276.818 Td /F1 9.8 Tf [(distress and performance on social cognitive tests does not seem to be an artefact of those being furthest in the disease )] TJ ET BT 26.250 264.913 Td /F1 9.8 Tf [(progression performing worse and reporting fewer psychological symptoms since the associations remained significant after )] TJ ET BT 26.250 253.008 Td /F1 9.8 Tf [(controlling for age, UHDRS-TMS and performance on tests of executive functions. This means that for our cohort of HD patients )] TJ ET BT 26.250 241.104 Td /F1 9.8 Tf [(feeling less psychologically distressed themselves was associated to worse performance on tests of the ability to recognize )] TJ ET BT 26.250 229.199 Td /F1 9.8 Tf [(emotions, ToM and sarcasm in others. This is an interesting finding that may help to understand the interpersonal problems )] TJ ET BT 26.250 217.294 Td /F1 9.8 Tf [(often associated with HD. It may be helpful for clinicians and caregivers to know that feeling little psychological distress oneself )] TJ ET BT 26.250 205.389 Td /F1 9.8 Tf [(may also influence the ability to recognize distress in others.)] TJ ET BT 26.250 185.985 Td /F1 9.8 Tf [(We used a self-report measure of psychological distress, and it is important to remember that self-report of psychological )] TJ ET BT 26.250 174.080 Td /F1 9.8 Tf [(distress in HD may be influenced by poor insight, which is a common feature of HD)] TJ ET 0.267 0.267 0.267 rg BT 383.880 175.587 Td /F4 8.7 Tf [(30)] TJ ET 0.271 0.267 0.267 rg BT 393.517 177.968 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 395.927 175.587 Td /F4 8.7 Tf [(31)] TJ ET 0.271 0.267 0.267 rg BT 405.564 174.080 Td /F1 9.8 Tf [(. This means that although the patients )] TJ ET BT 26.250 162.175 Td /F1 9.8 Tf [(themselves do not report having psychiatric symptoms this might not be true from a clinician or caregiver perspective. This )] TJ ET BT 26.250 150.270 Td /F1 9.8 Tf [(means that our findings do not necessarily indicate that poor social cognition is genuinely associated with fewer psychiatric )] TJ ET BT 26.250 138.366 Td /F1 9.8 Tf [(symptoms in patients with HD from an outside perspective. Instead, our findings may reflect a relationship between insight and )] TJ ET BT 26.250 126.461 Td /F1 9.8 Tf [(emotion recognition as has been demonstrated in related disorders)] TJ ET 0.267 0.267 0.267 rg BT 315.094 127.968 Td /F4 8.7 Tf [(32)] TJ ET 0.271 0.267 0.267 rg BT 324.731 126.461 Td /F1 9.8 Tf [( and a close connection between our understanding of the )] TJ ET BT 26.250 114.556 Td /F1 9.8 Tf [(self and others)] TJ ET 0.267 0.267 0.267 rg BT 90.200 116.063 Td /F4 8.7 Tf [(33)] TJ ET 0.271 0.267 0.267 rg BT 99.838 114.556 Td /F1 9.8 Tf [(.)] TJ ET BT 26.250 95.151 Td /F1 9.8 Tf [(Social developmental research has long posited the idea that representations of the self and other are closely connected)] TJ ET 0.267 0.267 0.267 rg BT 545.438 96.659 Td /F4 8.7 Tf [(34)] TJ ET 0.271 0.267 0.267 rg BT 555.075 95.151 Td /F1 9.8 Tf [(, and )] TJ ET BT 26.250 83.247 Td /F1 9.8 Tf [(research in neuroscience has supported the view of common representation networks between self and other involving, in )] TJ ET BT 26.250 71.342 Td /F1 9.8 Tf [(particular, the parietal cortex, superior temporal sulcus, limbic areas, striatum and orbital and medial areas in the prefrontal )] TJ ET BT 26.250 59.437 Td /F1 9.8 Tf [(cortex)] TJ ET 0.267 0.267 0.267 rg BT 52.799 60.944 Td /F4 8.7 Tf [(33)] TJ ET 0.271 0.267 0.267 rg BT 62.437 63.325 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 64.846 60.944 Td /F4 8.7 Tf [(35)] TJ ET 0.271 0.267 0.267 rg BT 74.483 63.325 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 76.893 60.944 Td /F4 8.7 Tf [(36)] TJ ET 0.271 0.267 0.267 rg BT 86.530 63.325 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 88.939 60.944 Td /F4 8.7 Tf [(37)] TJ ET 0.271 0.267 0.267 rg BT 98.577 59.437 Td /F1 9.8 Tf [(. Since representations of others are closely connected to our representation of the self, it could be speculated )] TJ ET BT 26.250 47.532 Td /F1 9.8 Tf [(that loss of insight and flattening of affect in oneself may be associated with less sensitivity to others emotional states as well, )] TJ ET Q q 15.000 33.247 577.500 743.753 re W n 0.965 0.965 0.965 rg 26.250 730.777 555.000 46.223 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 730.777 m 581.250 730.777 l 581.250 731.527 l 26.250 731.527 l f q 35.250 742.027 537.000 34.973 re W n 0.271 0.267 0.267 rg BT 35.250 766.011 Td /F4 9.8 Tf [(Table 4.)] TJ ET BT 71.559 766.011 Td /F1 9.8 Tf [( Correlations between SCL-90-R GSI score, UHDRS TMS and test of executive functions, social cognition. )] TJ ET BT 35.250 752.275 Td /F1 9.8 Tf [(Results shown as Pearsons r \(r\) or Spearmans Rho \(rs\).)] TJ ET Q BT 26.250 713.754 Td /F1 9.8 Tf [(Table 5 shows the result from the stepwise linear regression analysis. We found that the correlation between score on SCL-90-)] TJ ET BT 26.250 701.849 Td /F1 9.8 Tf [(R GSI and RME, EET and SI-M score remained significant after including performances on all of the executive function tests )] TJ ET BT 26.250 689.944 Td /F1 9.8 Tf [(\(Lexical fluency, Semantic fluency, Lexical alternating fluency, Semantic/lexical alternating fluency, Stroop test and TMT B\), age )] TJ ET BT 26.250 678.039 Td /F1 9.8 Tf [(and UHDRS-TMS in the analysis. We also found a significant negative effect of age on SCL-90-R GSI score.)] TJ ET 0.965 0.965 0.965 rg 26.250 402.422 555.000 265.736 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 668.158 m 581.250 668.158 l 581.250 667.408 l 26.250 667.408 l f 26.250 402.422 m 581.250 402.422 l 581.250 403.172 l 26.250 403.172 l f q 450.000 0 0 217.500 35.250 440.908 cm /I7 Do Q q 35.250 413.672 537.000 21.236 re W n 0.271 0.267 0.267 rg BT 35.250 423.919 Td /F4 9.8 Tf [(Table 5.)] TJ ET BT 71.559 423.919 Td /F1 9.8 Tf [( Stepwise linear regression results)] TJ ET Q BT 26.250 368.201 Td /F4 12.0 Tf [(Discussion)] TJ ET BT 26.250 348.246 Td /F1 9.8 Tf [(This study investigated whether performances on tests of social cognition and executive functions were associated with )] TJ ET BT 26.250 336.342 Td /F1 9.8 Tf [(perceived psychological distress in a group of HD patients. Since greater degree of psychiatric symptoms such as depression )] TJ ET BT 26.250 324.437 Td /F1 9.8 Tf [(has been negatively associated with both social cognitive skills and executive functions, we were surprised that more perceived )] TJ ET BT 26.250 312.532 Td /F1 9.8 Tf [(psychological distress was significantly associated with better performances on social cognitive tests and that less perceived )] TJ ET BT 26.250 300.627 Td /F1 9.8 Tf [(psychological distress was associated with worse performance on social cognitive tests. The correlations between psychological )] TJ ET BT 26.250 288.723 Td /F1 9.8 Tf [(distress and tests of executive functions were non-significant. Furthermore, the correlations between self-reported psychological )] TJ ET BT 26.250 276.818 Td /F1 9.8 Tf [(distress and performance on social cognitive tests does not seem to be an artefact of those being furthest in the disease )] TJ ET BT 26.250 264.913 Td /F1 9.8 Tf [(progression performing worse and reporting fewer psychological symptoms since the associations remained significant after )] TJ ET BT 26.250 253.008 Td /F1 9.8 Tf [(controlling for age, UHDRS-TMS and performance on tests of executive functions. This means that for our cohort of HD patients )] TJ ET BT 26.250 241.104 Td /F1 9.8 Tf [(feeling less psychologically distressed themselves was associated to worse performance on tests of the ability to recognize )] TJ ET BT 26.250 229.199 Td /F1 9.8 Tf [(emotions, ToM and sarcasm in others. This is an interesting finding that may help to understand the interpersonal problems )] TJ ET BT 26.250 217.294 Td /F1 9.8 Tf [(often associated with HD. It may be helpful for clinicians and caregivers to know that feeling little psychological distress oneself )] TJ ET BT 26.250 205.389 Td /F1 9.8 Tf [(may also influence the ability to recognize distress in others.)] TJ ET BT 26.250 185.985 Td /F1 9.8 Tf [(We used a self-report measure of psychological distress, and it is important to remember that self-report of psychological )] TJ ET BT 26.250 174.080 Td /F1 9.8 Tf [(distress in HD may be influenced by poor insight, which is a common feature of HD)] TJ ET 0.267 0.267 0.267 rg BT 383.880 175.587 Td /F4 8.7 Tf [(30)] TJ ET 0.271 0.267 0.267 rg BT 393.517 177.968 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 395.927 175.587 Td /F4 8.7 Tf [(31)] TJ ET 0.271 0.267 0.267 rg BT 405.564 174.080 Td /F1 9.8 Tf [(. This means that although the patients )] TJ ET BT 26.250 162.175 Td /F1 9.8 Tf [(themselves do not report having psychiatric symptoms this might not be true from a clinician or caregiver perspective. This )] TJ ET BT 26.250 150.270 Td /F1 9.8 Tf [(means that our findings do not necessarily indicate that poor social cognition is genuinely associated with fewer psychiatric )] TJ ET BT 26.250 138.366 Td /F1 9.8 Tf [(symptoms in patients with HD from an outside perspective. Instead, our findings may reflect a relationship between insight and )] TJ ET BT 26.250 126.461 Td /F1 9.8 Tf [(emotion recognition as has been demonstrated in related disorders)] TJ ET 0.267 0.267 0.267 rg BT 315.094 127.968 Td /F4 8.7 Tf [(32)] TJ ET 0.271 0.267 0.267 rg BT 324.731 126.461 Td /F1 9.8 Tf [( and a close connection between our understanding of the )] TJ ET BT 26.250 114.556 Td /F1 9.8 Tf [(self and others)] TJ ET 0.267 0.267 0.267 rg BT 90.200 116.063 Td /F4 8.7 Tf [(33)] TJ ET 0.271 0.267 0.267 rg BT 99.838 114.556 Td /F1 9.8 Tf [(.)] TJ ET BT 26.250 95.151 Td /F1 9.8 Tf [(Social developmental research has long posited the idea that representations of the self and other are closely connected)] TJ ET 0.267 0.267 0.267 rg BT 545.438 96.659 Td /F4 8.7 Tf [(34)] TJ ET 0.271 0.267 0.267 rg BT 555.075 95.151 Td /F1 9.8 Tf [(, and )] TJ ET BT 26.250 83.247 Td /F1 9.8 Tf [(research in neuroscience has supported the view of common representation networks between self and other involving, in )] TJ ET BT 26.250 71.342 Td /F1 9.8 Tf [(particular, the parietal cortex, superior temporal sulcus, limbic areas, striatum and orbital and medial areas in the prefrontal )] TJ ET BT 26.250 59.437 Td /F1 9.8 Tf [(cortex)] TJ ET 0.267 0.267 0.267 rg BT 52.799 60.944 Td /F4 8.7 Tf [(33)] TJ ET 0.271 0.267 0.267 rg BT 62.437 63.325 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 64.846 60.944 Td /F4 8.7 Tf [(35)] TJ ET 0.271 0.267 0.267 rg BT 74.483 63.325 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 76.893 60.944 Td /F4 8.7 Tf [(36)] TJ ET 0.271 0.267 0.267 rg BT 86.530 63.325 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 88.939 60.944 Td /F4 8.7 Tf [(37)] TJ ET 0.271 0.267 0.267 rg BT 98.577 59.437 Td /F1 9.8 Tf [(. Since representations of others are closely connected to our representation of the self, it could be speculated )] TJ ET BT 26.250 47.532 Td /F1 9.8 Tf [(that loss of insight and flattening of affect in oneself may be associated with less sensitivity to others emotional states as well, )] TJ ET Q q 15.000 33.247 577.500 743.753 re W n 0.965 0.965 0.965 rg 26.250 730.777 555.000 46.223 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 730.777 m 581.250 730.777 l 581.250 731.527 l 26.250 731.527 l f q 35.250 742.027 537.000 34.973 re W n 0.271 0.267 0.267 rg BT 35.250 766.011 Td /F4 9.8 Tf [(Table 4.)] TJ ET BT 71.559 766.011 Td /F1 9.8 Tf [( Correlations between SCL-90-R GSI score, UHDRS TMS and test of executive functions, social cognition. )] TJ ET BT 35.250 752.275 Td /F1 9.8 Tf [(Results shown as Pearsons r \(r\) or Spearmans Rho \(rs\).)] TJ ET Q BT 26.250 713.754 Td /F1 9.8 Tf [(Table 5 shows the result from the stepwise linear regression analysis. We found that the correlation between score on SCL-90-)] TJ ET BT 26.250 701.849 Td /F1 9.8 Tf [(R GSI and RME, EET and SI-M score remained significant after including performances on all of the executive function tests )] TJ ET BT 26.250 689.944 Td /F1 9.8 Tf [(\(Lexical fluency, Semantic fluency, Lexical alternating fluency, Semantic/lexical alternating fluency, Stroop test and TMT B\), age )] TJ ET BT 26.250 678.039 Td /F1 9.8 Tf [(and UHDRS-TMS in the analysis. We also found a significant negative effect of age on SCL-90-R GSI score.)] TJ ET 0.965 0.965 0.965 rg 26.250 402.422 555.000 265.736 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 668.158 m 581.250 668.158 l 581.250 667.408 l 26.250 667.408 l f 26.250 402.422 m 581.250 402.422 l 581.250 403.172 l 26.250 403.172 l f q 450.000 0 0 217.500 35.250 440.908 cm /I7 Do Q q 35.250 413.672 537.000 21.236 re W n 0.271 0.267 0.267 rg BT 35.250 423.919 Td /F4 9.8 Tf [(Table 5.)] TJ ET BT 71.559 423.919 Td /F1 9.8 Tf [( Stepwise linear regression results)] TJ ET Q BT 26.250 368.201 Td /F4 12.0 Tf [(Discussion)] TJ ET BT 26.250 348.246 Td /F1 9.8 Tf [(This study investigated whether performances on tests of social cognition and executive functions were associated with )] TJ ET BT 26.250 336.342 Td /F1 9.8 Tf [(perceived psychological distress in a group of HD patients. Since greater degree of psychiatric symptoms such as depression )] TJ ET BT 26.250 324.437 Td /F1 9.8 Tf [(has been negatively associated with both social cognitive skills and executive functions, we were surprised that more perceived )] TJ ET BT 26.250 312.532 Td /F1 9.8 Tf [(psychological distress was significantly associated with better performances on social cognitive tests and that less perceived )] TJ ET BT 26.250 300.627 Td /F1 9.8 Tf [(psychological distress was associated with worse performance on social cognitive tests. The correlations between psychological )] TJ ET BT 26.250 288.723 Td /F1 9.8 Tf [(distress and tests of executive functions were non-significant. Furthermore, the correlations between self-reported psychological )] TJ ET BT 26.250 276.818 Td /F1 9.8 Tf [(distress and performance on social cognitive tests does not seem to be an artefact of those being furthest in the disease )] TJ ET BT 26.250 264.913 Td /F1 9.8 Tf [(progression performing worse and reporting fewer psychological symptoms since the associations remained significant after )] TJ ET BT 26.250 253.008 Td /F1 9.8 Tf [(controlling for age, UHDRS-TMS and performance on tests of executive functions. This means that for our cohort of HD patients )] TJ ET BT 26.250 241.104 Td /F1 9.8 Tf [(feeling less psychologically distressed themselves was associated to worse performance on tests of the ability to recognize )] TJ ET BT 26.250 229.199 Td /F1 9.8 Tf [(emotions, ToM and sarcasm in others. This is an interesting finding that may help to understand the interpersonal problems )] TJ ET BT 26.250 217.294 Td /F1 9.8 Tf [(often associated with HD. It may be helpful for clinicians and caregivers to know that feeling little psychological distress oneself )] TJ ET BT 26.250 205.389 Td /F1 9.8 Tf [(may also influence the ability to recognize distress in others.)] TJ ET BT 26.250 185.985 Td /F1 9.8 Tf [(We used a self-report measure of psychological distress, and it is important to remember that self-report of psychological )] TJ ET BT 26.250 174.080 Td /F1 9.8 Tf [(distress in HD may be influenced by poor insight, which is a common feature of HD)] TJ ET 0.267 0.267 0.267 rg BT 383.880 175.587 Td /F4 8.7 Tf [(30)] TJ ET 0.271 0.267 0.267 rg BT 393.517 177.968 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 395.927 175.587 Td /F4 8.7 Tf [(31)] TJ ET 0.271 0.267 0.267 rg BT 405.564 174.080 Td /F1 9.8 Tf [(. This means that although the patients )] TJ ET BT 26.250 162.175 Td /F1 9.8 Tf [(themselves do not report having psychiatric symptoms this might not be true from a clinician or caregiver perspective. This )] TJ ET BT 26.250 150.270 Td /F1 9.8 Tf [(means that our findings do not necessarily indicate that poor social cognition is genuinely associated with fewer psychiatric )] TJ ET BT 26.250 138.366 Td /F1 9.8 Tf [(symptoms in patients with HD from an outside perspective. Instead, our findings may reflect a relationship between insight and )] TJ ET BT 26.250 126.461 Td /F1 9.8 Tf [(emotion recognition as has been demonstrated in related disorders)] TJ ET 0.267 0.267 0.267 rg BT 315.094 127.968 Td /F4 8.7 Tf [(32)] TJ ET 0.271 0.267 0.267 rg BT 324.731 126.461 Td /F1 9.8 Tf [( and a close connection between our understanding of the )] TJ ET BT 26.250 114.556 Td /F1 9.8 Tf [(self and others)] TJ ET 0.267 0.267 0.267 rg BT 90.200 116.063 Td /F4 8.7 Tf [(33)] TJ ET 0.271 0.267 0.267 rg BT 99.838 114.556 Td /F1 9.8 Tf [(.)] TJ ET BT 26.250 95.151 Td /F1 9.8 Tf [(Social developmental research has long posited the idea that representations of the self and other are closely connected)] TJ ET 0.267 0.267 0.267 rg BT 545.438 96.659 Td /F4 8.7 Tf [(34)] TJ ET 0.271 0.267 0.267 rg BT 555.075 95.151 Td /F1 9.8 Tf [(, and )] TJ ET BT 26.250 83.247 Td /F1 9.8 Tf [(research in neuroscience has supported the view of common representation networks between self and other involving, in )] TJ ET BT 26.250 71.342 Td /F1 9.8 Tf [(particular, the parietal cortex, superior temporal sulcus, limbic areas, striatum and orbital and medial areas in the prefrontal )] TJ ET BT 26.250 59.437 Td /F1 9.8 Tf [(cortex)] TJ ET 0.267 0.267 0.267 rg BT 52.799 60.944 Td /F4 8.7 Tf [(33)] TJ ET 0.271 0.267 0.267 rg BT 62.437 63.325 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 64.846 60.944 Td /F4 8.7 Tf [(35)] TJ ET 0.271 0.267 0.267 rg BT 74.483 63.325 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 76.893 60.944 Td /F4 8.7 Tf [(36)] TJ ET 0.271 0.267 0.267 rg BT 86.530 63.325 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 88.939 60.944 Td /F4 8.7 Tf [(37)] TJ ET 0.271 0.267 0.267 rg BT 98.577 59.437 Td /F1 9.8 Tf [(. Since representations of others are closely connected to our representation of the self, it could be speculated )] TJ ET BT 26.250 47.532 Td /F1 9.8 Tf [(that loss of insight and flattening of affect in oneself may be associated with less sensitivity to others emotional states as well, )] TJ ET Q q 450.000 0 0 217.500 35.250 440.908 cm /I7 Do Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(6)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Huntington Disease)] TJ ET Q endstream endobj 334 0 obj << /Type /Annot /Subtype /Link /A 335 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 440.9085 485.2500 658.4085 ] >> endobj 335 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/files/2016/11/table-5-HD-0003.jpg) >> endobj 336 0 obj << /Type /XObject /Subtype /Image /Width 600 /Height 290 /ColorSpace /DeviceRGB /Filter /DCTDecode /BitsPerComponent 8 /Length 50369>> stream JFIF``;CREATOR: gd-jpeg v1.0 (using IJG JPEG v80), quality = 82 C    !'"#%%%),($+!$%$C   $$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$"X" }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?3^,:Ŝ e}qz\E jB9`1U?6/<_r^[|aAᮦlٷiv_֓`t_B/9@)x-|/chtyK1u3(u^p2qkX|D [ tIqYuz%橠qye=Մhp_OZ-Gs )x㔟B/9^oiҬf`M&,RG2(2yP|V^#|=guX[j!շI zcg4cԇ'KMmk 6S'~:OSP1 (k? >&xtP1 )x㔇sOR>".OkHK h7duYٕV5/<_rgzk_q\s6XV˃4R2BXR&ХoRm7 ^&xy߆u7Pkװ L2JhU$_]k{t)ғPu?j0k.޼Sk\sYS7(MOYS^D|1$Db ĐĂуWZ%އ XX!)RAݜc,t#KgKMuivVW dc>l8\ I$8Q5-Oڭօfu;$,q# qPk? ^&x/&ХoWx ͍LߤSxr"p쏹ӌV~4a,2I,z?&xk7 ^%xyxqx[hz7^M#P‚ CSߊqs뚮mmeiMs@ݥ(>b06KoM?5̥oW5Xz}6^ZMKr+/@lx|M_MgGsB/9G&УoWOEsB/9G&УoWOEsB/9U".wC o "Ƌĝٔ~5W3@?o@ 3'^&?k? >&xt?5<_rq2/9]Eqn Ƕ^\(oFcPs[L OB/9K (㔞5=@[A[$SSϱ6wfI+qӯ$s?B/9G&УoWOE8~!G5Ų(vyk~UgiR7(}/zXz>-[ڛ+0[NVcpJJ>â lg/<_rYR7+񾣥x}vK+k|k T8-3~n ޥiKozٯ۟:"9 e`a6QmlȥoQ )x>-OҚGHι,e e80$f_|`boo^%<%Wz;)Lp~\x`?OB/9G&ХoW|A]qyt yg|m=cCt3K%Iy27((Iq>6?5/<_rMg^%xpZOďj7d#\%{\,q߼/9_5KF;kBXJy&K0c򟑸4֧w?O x#E,xS,zomaexH[džVghKY乸gvi ]FO?'_K@?B/9G&ХoWM'>_^6Lg {a7 3#1+8z<|Mo&ХoUMWW?[čbј~;8O\WD W ޕV 3瓑pGi? ^&x/&ХoWi/t2 WԴlam2ᦴ(aHg#x]_*5%#ⵏ(LН H 3NvkkqB/9U_}oe'oB!h!hGH +KƝMuquLG:E&HFx[xEi;-i#t27Ta#`MPӛv|c(:RE `16q s NDV)uiN+IpRzQq>0w lPf@ y Cφu["ǩVei+,M!FxԖXU8ɿw⻰V+=LXOw4a "fnJ6s=ilz}TWcz4 .v ZW9=M4'}zRQltRɶWwaX(TP@P-&FhRdRPHzQHz1wxzm_U(Ŗ9˶ sXSz 4QF-m1Y-m/@>YTm6/knŀRJ@+'Teizw)v8 vtC7" ;a}iZsim Y,=U\":¬YP¬*i@}r(QFEQFhȠ֑z+⟵Αz`ir(jXv@p3=]ŒHXKxTX( 8&F@ E&2(|}QN^峊|1K@u k+{Xz3@_O/Ő\Sf1;aG\&iR]:Ą-msoJΊ7pldeE 39Ejc}wm,c8[SUbQ-eJY `,a(=Ni"x-BFp*ym!*e7(r}3Ҹ3Pm3ʐJu<c1H O':+.h)S'֕fm\9լёLfvD@@ V_RtMCMSY_K@Fʮђ ?Jbٖ{KYAVE&E #1A 3P.л9,1\ռѺhKc}*X!4w9fU֦)r(cX?+$W15i(F[X$xwNUӡ8Q`>€M€9-a]3K#E4.--u_x^ٮ-[y5p6t5뉯Sd`r7$ Oq]#ݼkVlGQ^!JUNJtOWEgMfXwųy;z u*?Jw"h}\rj׼5煯4]+V٨qXF=jׄ|-x[Xfk |1O;H8$Lg-6z<#ԡU~+2!iSܒjm~LYk^+o 15I6ÞbksGg#گV'~I.u Y/'\%QfP9ݖ}6m|/j79$ %۬RrzU3@ѵm7źq a+z'uo{, )l#owbGW}anG'wqZ'5=BxI.!va:15%⵻洽H|wI=|)t3.b l-_O+)? ĀlQ9\ہ]@c&UdKΛ%~p*xG^kQ)~2ZfmvƻpctGq~Fٽr֊"? (vEYl7-7QO4y0Gr08>Փ-Eblo/Z6y cG⨠b'Cf 9 "i{MEmmCyWF ȇ9ݸ5M'i 6!S|H}ͼ?WӯKdʅٷ3ݸ6,@$ biq6㗸k3EnZC2s 掠u~jvr\Yt`T26#<6u @>yYܓBB|DbǍf)xtE&\&ХoQ )x v~lm? ^&hOB?9@6њZ?6/4rMK 3 )x㔍iS0h/ðg_/`y<_=:1A5'd H] *xPS6~&h/&ЧoRΞ反%㔿OB?9LgQErE?4rx5OrQ\*x-㔇"G?9@Mmqž%h;i"?9@Eo?OE6 捂㉏ʞ%xR%x+m1J7Sħݣ㔧 xۼrMK iR7G(g\.^&+D )kZ/"$] ozxC3Cm?EG&r[Cb5~wԅCugiR7G)J>Lh8o>T/Q㉏ʞ%> urB?9N6/4r=sKG&E/4rO??1LjA|=>~(ҩMK iR7G)h=+M?6/4rhW1 )xm? ^&h-a]3KmCIokMSM(/aÐKuږ JQcne*1u_L=s66ZCz7 xYe]UqM/4yϮi[8"H9E@í%u=g@ZcH3;!*SInt>7$WƤcTM:Y4iOX[MCZ \ivnI] vA L#9R)YLs%.s,8֒B%}WO 28,'#>]P@.Wn2r.hgTi RCsu-o27lPC1^#|2W{R Q1ƈ\bi8gQ@hO1O1 E>yx+MEyg--ak+5f)=3;b·_]6=N(KnB8,1]൷f y?֚6% )07H3ִ?:{;-ukbMI)*2q'o/ښ ͼQiU%Պ ;bX ŘdblR898q"FUQE Pi?T"~`os\&^&+D )hj8i[Im϶ktYe#h`yŅ89Or:1!`fݼbieHeىd98s^𢢬QP=(`O.(4v( -uonmo"߲`3FR=+6J xH֖c-o 1}P|OJA\ƮhWO\Ʊ#hP3((("? ("? (?Cg5+-_2CUYkM-jX[kҾ2,-+)?݀3ڕ 31Xt<C\\U? ⵵ '/+K8-կYZXP^P|L~U]U64%MN 'q8=jt<CG,ŧ@]&5եFWVy|ݦd ǚjWӭf9mo[!RS=ӏ ?1X?fx;+,^imo,b\A7k{jrP $|xZOV:|]Ccpq< <CG,a}t|+~.V0Ę!C #\FmIckF<硍Z3J Aw<C?溸[x-wʮ\s?|CG,a}M1@,a}o Vtأo V|C].>c@,a}9ψ^W!_ ½#J~!ZNt8[ 3f+Yfx7+Y 1Xʇ7֗[#qEVm^]cHϽXl罍i"\}6C\4 Y ?F(?&|fj>#xFš,2)$v#)~A"pėPi?T??Z?Y obtخ{76:, \ClfN%EVa@'ր#?OY Vmi~1IGxmwQib2XjVwO&=Ķ9is,Ba!u=7I:Y O|C\ڶ:jke,i7P80xk@09Y wU7񿇮^1EkzR|r#Ǿw,a}w Z]# c=}sa +[i$w& 71igb7-o}{4c*E3Vb>΅[il-ʶOLȧ q9o VY 2ڔ~'ɭ%V42 D7,AW s|i Egqs.%{8")r/ i] ]wx_vq_nB2G0vEP˯ .֖d]_ƬF>IFׂ?}3iRynѴjzA N G ÚWzvn ȊDHGh\JEX͟EmU$ 0~~@0?wl&,Wڬq-?gnUϖqSzTn4(9?=[X-nd(cq^Sόuj:cEݶ`Y @n^(hF~?_%+evI bӂ8l|)qZq#r<953@-g.~թ?2ɜbn" Ф[ӣЩ3ʀJHњ5xug]6S4f|ZLњZCFicz߆9K86Qq*zc~n?/|9~bbL]FD|v7R4^&a#{ۊws4O˨-n݆b/8sQ7Ï 5IZ*щ r{WML<z[z8IaLɺɕ%9<{ &hmWRgb`ށeGer c)>jCpLfYo:M"Pݐv8t٥r#_V(#]5X 4\npđ^iZc2A k&hok),[IJ2 a\r<0c}څr)D@Cg9:cf9W]O5~֬I7c;@sP' !c|wM!G-o퓎њv=66qvЮбm$W(3Fhњ(4f ~"ZGmsH-3ހ:qA杚ּ9juo?쒉.#?M.i2]K՘h\cf&omFGߏ@Lg3@:ݕŔ~̒;!v=NTwVPT5 `J3@fs@{I/[襫.^&x(![赠 wp)GV3Kʶ֙ii 6 ?19vj~ aӣs0w{dwgp#+w4f1/<_Y\X#[YHƮ#e=l Q3@sK]1RS>#I$rpc8Z )sK>"ȷt.Oca( ~2.|Wሴnϛ$pǖw/_\áiu-k]=r^/O?m 㧊?k9?OG_K3e ?utP1/4?eCf]=cx?o٧WOEs2OGn_6i(@7lQ۩Ŗ(Ro~,mv1/69GS8VּYUlڕ򻔉>%`)Eu7گUoߋ<7qe}Y%̫tezL$g%_Y(u h#>άkQF G<6d@UM{(.&b*c:Xd^gj;-Luy4& Ic IJ~_ݾ-#•zdVPZ7V)Ks-25gp 3Q$_]Nhb1\l9PH.Ro}WQgѽi'F` H27 C. =sk{鼈VCK-e':ωAf6(+C,3$ת?B)>#hzqqΖe5WVRX}8<ѵ=NPI$M,HqĒ I8#$ /4?eCf]= ?eCnG7lQ۫9o٧Q/tc_6(cx?z(  ?u2OGn?eCf\4GQc*[KPm!N|$w8kk O iqpJto4Pkڧ=41]xGaʌ 95vKx. (M'?|?R\ir/N<3߿oJVLӴͥ#ym, 郎\T݋qk}`]ڂyCmosw#Tg< Q-sim@M!Lq1c;φ7sj Q~%Fb$cئ=ߋxH~$BתnM6FOGn_6i(.1LRyx'YVȼJ`|`ycں/oۧQO3  ?u5f]AI#t`A4YVytM:Z3|օ1"=OW.gi{/[kyE(q?054Kt4}cVΓ.y5@m`qһȔh02}i濱eCf\橤x|m>'2GP<<?#?ac><?#?ac><?#?ac><?#?ac><?#?a s?a >Hl|yCG?%:zWKYxմ;SRILgr.@[Vv~+3bF'F8~;=KW2,|yCG?%tmҹ K><?#ҹ K><?#BA@u i$csa >G|yCG?%Mg&\|yCG?%tlҹ K><?# K><?# K><?# K><?# K><?# K><?#g'-?5ޓ><?#埍WC7dOm,2oiɺ<#dg Ee9"Otx K=E+ncٛtF X wcUV'TQj~-F]^z[VMgY8wvxیɍOj]Ҽ|_'$dYZEٖ7\ ܸGuxMH&xdYm/y4a[fK>Z,cW.,x@?#M?a`?%K]=ygS}S^[ٴy09I{c><?#*Z~|39.^<Ct6.1MWk'֯gGhrNܢMA$dfY}#FH*m,Qڼž" Ě4Bdžo7ȍ^4N]ObZ:%WtH$12rVg{{b;+?a>|39.:uA5O_'_KX͗F|d>&$?k8,n|+5F ,|$] w( ǟ0gs]Te-|5 '$9$v/& p~GL}J/m-&3hW%~ukT_}Wx~ [qv9#;6qj@z>N9G|yCG?%OEsa >G|yCG?%OEsa >G|yCG?%E+tV|]lږ\ WM"ҥFMvp9Eok;[yֺ-kL\(((#ր(q}Tr8ljQuEK4VmYo]N2)@_U릤j^076Z4q&&Qq,;n F{D4=25EգYU/1f rOGTun+摌c~3q֯U(KH#RhQFhȠLZ2=E-QFG" (dPE ( ( ~"ZGm릮c'-?5ހ:aMh4Lѭ\em<2/$ ;G?G]_Þd%syA48䔸ȼO#TSTŬנ]Z*O&x³7Dq?c7)~w 3 ttC/C(4q?kO\ƎG'$K]=#dndvhgFִY.-2DX@>r5^&Ι0㾸Mٚ?,2yACn7`nWXRԤ+YXܘLB ;G-:@HfI\yRnݐv9#9ⷾ>ⲯ-OKh(PKGpn`g 53ǙoFcm>lӐ+m%&"u2;3L'Rji [xnVsT9i~"c{wo>4owxYҤ]~X(6 N샏j-eK9"$o<3 5(Kgqqi:|s<*{;@y'E!mH"VJ 2=Hmu(z|6rϨXXU  88_J . q\1\8sυG֠kWkXt`bؔ:N0 Z5?-pR5׷ 6mnuڄsgP>V}=vxDd QF{8&VxSo<.mq!R0r1Tb.uW±XYgxb F3R+R]y`*(ݳFA 1MGC?cj~-е kP)`9w+1€͎`s[|y Ssoooyn?s<zUsK@Wǟ?vqxfݶ"v'\8ȮK6j:fkcq-'il`6 MZ\fFÆ؀UR¦X\x\o綻C$RZeGR5bi𕖟ZEX#8O5m,m4UEIcUdD-viNL+Ɔ` t @$)!k3|5{61NZh(J` tnסP/Flu#}WM>%?cq\Q[[ºgAE]赭FOo.VGi1_Zx^\mL>Z5eOs@Y- !%]Ѯ395&ba\>қdm9+_Hk-WO[3kt>' ˑ1IrUo(%tu/sl'1'.r9GP=bPhx[l3t?Z<^i3H}qu-nYg7 HvǍNsڻWt i)6uYx_4Ui3KgWiUL& :*t i?*t iHk3wKƚ*4 h;zxD@%4WSl5 3oKƀ5sKƏJi W;\G%^qjY_x_4x_4EeUU W;TI W;\@VW%^qx_4EeUU W;\G%~qjQYx_4U W;TG%^qjQY_4Us??ia#N6 W;\\hr6HXҜBp5 rO^Pr(zi+4 hMNiqf*?xA֙Q!e216cfYoK?,?7R05Ji|WsKƁ?$K]=p?AJƜV7(g}]7%~qjFJ?A/CoK?# @ޗI4hczgG4?:O/Yh??Ɣ@ޗqjY_4U5A5O_'_KU-_zco ]!'>S'У𞈒kZj2Dk:k..?>+MsL?MK4 xƓzg'Sg*[$`Bs)9|G3ko М,}r: cA/4լC" y%x5S DSAo3qڻö6Fq\ҘI0~Cп */#:tO*(7 oQ΅@]7S+JgB.3MT Ң3п *'#:tO:(3 oR3MT Ң3п *_?´ Ft/ G#:tO*(7 oQ΅@]7S+JgB.3MT Ң3п *_?´ Ft/ \h6:ƒ[:t o\OZkHӍj hy6?‘5ėMS+Rz }/imo{ytTI;H#<`d;@Ҭ -2 ծ.LR4f@c'nqӞT𖏪eA<m}㜊O&ň. n ԶsϹa=vEאhw7Y[Hc\$~c6wF=*ЮkwFMVWl<[ .?Hm*5+sL|wڤDOa9~ϧƩok! аgC* tO'S *h▀GxsFox3KKm?HT0<‘[fMU(~ˑ` d}윃\ƛKiyX um-]6[Z9.Q H'WOȱ]-irUhivwJ#gK`7UA+_G`lŤ3]NLc'V΅@]7S(gB.E05 h_p"BN>STO h>}%|n?O?ȟ:E-XgB.=;KtpzFZ'#a8#(aKx,qUQ8éCoW3wFOxr1{[tcF=븮cX?(W oQ΅@]7S+JgB.3MT Ң3п *_?´'ǺgC=c i^8YӠ([ºgAE3^p63f/+æ.hn5[[؂@NaCڥf}7{8EglhUy'ksӏzW~}/+m;Yo%FBȬqk[~va3sus>v] });ϴE=chz} 1Zx'RndI,b¶ņ3jxB^ /w:tAYo ^)\KD_?R}/+moאGG$es;σr7'LJhS;Ǖ`{S}/+ĿZ;?:(G!!+I,xEYsi{u/tx/ń$x Dr^*d7$w^3Zz\? 5=-~o&8UFV9Ly?RB{iᆖ%؍%bB"< $7c8 t55׃o/ʟyxp ϵ@{7"BE=cy dd߇Kpy*UǕ`7/<iEK'H[xܬhz} Cf~im"# *XGP+<'^%ς-k:ǧDcX yp;ߴE=chz} __ΗwOH=ݴ7{6Be~PI\k 'xs4¶G l?Mo/(D_?V+oН 'xs4УXXBw?[G+oНq-ci?t/D<#5?oCyG 'xs4·I;ß- E=c/"B?[x#&V;ß- E=chz} m9?[x#&7}/+?N ahm97clЮcUgN-o?՟V;ß-N ahXIЬV;ß-?N ahXG"B?[x#&V;ß- E=chz} m9?[x#&+|Cñ"isv.# 9#VF! A4PAFzYH[X`##rB eaKT5$ɕWscq3⎣P隶dj m2X[4Hǽ%t{N=GQY.fM6 $%Cz̞ 4-Y%͟ e,żJP4z<3޽k̗mHw ǿz$u[k6]bD}R[y^`Ws_xMfH/ ӭ$`Гp@)@qmgaaag\d-2ڳ Xd 6TG9-] K/, <đ`) F ffm6WO>SF>91ב\2Z yt-!"&6XSkc"&4[ xs"$(=vII?l-| A !>|piјnAĈ69Y7C3lNR_.D庩4 -a3FдSꥁ0 rqh&,=;ѭV>fSzs44uM/O[P)ċn$r<j-K4e`ܮBE2!9Ą`p3 X 'αn9׿bU[K![%b~\im5o*[Otu_[ő$g`U c%goaU by3I5bN//,"2H=FsxA|IF5;*&kt+!€wd:)>}ZZ%%{Kw6] |$:I"NW423|6eZ4anΑ>VA@rIm+xth: nH7#D̲ci< {fnu[kֱ*c@XL;/zvYx8muܨ]ę@8bw\bp_4vvXVRBw'k:.$k+mi%$4Łc!5Ț ؈挾92e"&iƥw?n$բku]_l`1Yr|Qֱ{RhYY#S@`Axkj6~Z\ڥ0!Q!nԁ3ǵ`2z^߬ i|vQ"6+G9$ӳ\QA.!$d ۆֱiwqJ$6#wzċ\Y[(1_1RrDw ng45Zܗ4c 4Fff*|4?Zvzp"iΠ0$`:wd'Ļ3]f-2YX^S"8m qZmmH`}&x V-~<SYM;XTOtYiB1F9;Hotnl&EO[\%ش$dr?[F-+mf\HdD]Ж@d<3gkhgUA ,[<+84tR֛Jrٵܫ1 2Ȯ<353Qu䐺́ ;?".#@}-."a}Qh޻^ggȯ1Ĺ<qwPjgspDD!AV\vvWG{1" e)z+y66׬t[ND:h4ZPc%GM9kgxÞ!Գ[Z,=ԱmxcyZ lёY#QtV(DR$fgǶ3>a.#^Owuĺ}ŨExl{YUK!lYdzko:nY&;&O0 ߭rzG|O'ěu{mH )tXȬ  Psײ(o^+OGSKН%H.@;-g4*+9,ʪ0Ox.qB#֌םxƚŽ)mN۴jȠXsS%`mN;{ĈA8q4ǤdzџzKՆ,:](Ȇ0 ˀ9-~'>_ _=h)HHz5z3^VģP/!Ouo]*HF,c>/ UַDBdqzP \Z@xwI}8)* I[;Ԑ_k>ܶoq,^T,v$ ӴACy!,7"O9*A=2=hȯ/ukԡՙ 鷑U\VM=5k3H2FP6P˝W#?}UU( q lx? :{Kv$ ׊#֌ZtoҮmI ]K' =;k;[}bO6w j3i4,*|X[8Z+?Z^J̣uʡ1ěOG=2qֻ}Q@Š(>SO#z t-mw-G7~Hҳ5 vn K>F 'O[&qccI{y)(.UXRpOlq mjn6jHF"[p1$)#e9KP6.u+hfUp n),| y,$yo` L3uI$ sWY񶣢xEЦ[{ n973PoZ. S=mr Ρ, .ȩn| ^]jW\&9i .!WkȴxoºX]O$;)v?j;F 崋[‰%d1L',6$ mݑe.rpkbᮃgǧԘ%݉' %d߹wĀpKZƚņyG-oo !AbX99:x_k*?5k 7v C+ `9Sw7?4:l,/_ @(pOUgL-{18Gެ9-|$湘9[:\08 m+{#^ÒO7Q!ol;t V=J𮓤ٵdv u#\;0 i ccoc^\ $|Ġm )>\p=Ǻ<[٥֒gb%X?QjuK]X5廊 -aqw;[hT5 ڊǨk2),MN:.D  cZxZċakHf ?"2/m^1>XHQ੡k_xx%!5nm]F}~F~ڨZ aêE4[2^R:\"8+ l1\~_O6\MA ۤbA c ʮK0 \MǤмCZvٕ21֛xk i7,m:xey$GTvEb l08'`gCÖ"_7dIvݧg d1MQUDjj!cX@ ܀K~hwH $R,9=yy>5ktC\`3pŀ<w>u;Nt'Pӡ7鼱v~ۣUX\(A 8|u;!L{_g7O'q ̣ 掣=@5Ij-#&m r tqii>48'q8*#k]a!no6McR͌`1PBO)E\#դw ,4 4U@WfmIQ,&`ܧ1qGͦie~20!Fr8\Ikco?F-Z.'2żib1|J:qs 1 ,jvaQBIsqD$ϧ7 ;[V8+ɸ ektfJW$,? MP׬oel$[3I Yݻ$ EgiR] (s^Ymj#mhOwzבMf;#U`2u/Z4Q->4[ۉcme8G80=+ |:?0Xg5+zfgOxG}.NL{I;)$w^&:hS}eI#:ap'hm N,uX+G6ԕe8">j薶ik:ދIıl />ݓ]O{4ل'ϳ$p0\w^6ҾI\QK&݈mݣŸnfH,8>ZI=WR4:,E5(nZ9V%trF$c#ҹ+߄֗ћ[ۙi -E}L䟛a[g(xذ8 G"xi;^YeYuotMŭ4w$ E (n*0:xf}Aơ%7F4lr@ssɦ'k-开Msɏh=Mk}6H 'M Q חS2;=wMmlf,/n<)܁/| CGѯ x[6DwFvr2ޘ9 dw 3T~trvy.#dYn rⵅ M\Gs^ڶh467Vrg+'+Ft) gsqPH4nm~q.gϔmC=R+{ QMX6GC |]jVoe%U24aC߈`65-m,-Q"Q@U[τڔ?Kv7QK%wͳw'v]aUEDn S^Zȷw6"~9mZFss{@V$Ѷx`xR%R4ll >q׊5o h^ɤivqk}Kk l`!W@&oֶZr4yӶl *F@hn:*Y%ZIqFXYwt°/=iψҭﯮcGWiumuo 2TRTvrNxx Z֍_AK IC@@ m)4m`sot54}OQ'w4fo2Ddҹ iVZ?jn涔J?0E}?RimTX˩ϧj@.hZY*@@_yAa)=PEX#M/{ln灓˲_3Uжcgz'm<.1}.LX݀=QxWDմ_iVֿPڼ>Z\@G\ ~'gm ޡ=krj:}}y.UHgDd%Keslw~i)4mW#i쥽dN9ޙ5Ӽwx[]^y xRJibz5x;!.m-k"o7g S|i^,eՌhWvjJN#~V8]j\ͣ˥j5,!mGw)'J}V`f& ͻ@#8Ϝ#R#Iz}Ubwyy ʀv]n= XyZQD89MV#@w񭷊ZsZZƋ$wW^H$2m1yxVnK-ai-7s('={W|)ע ?IisK}H2A5c\cq4M3N.m#x80p:P#E<;&} c+QGR;V/WZ^i5W<VLaӪhƻѭm-ZHYc{i`.O ^+eu($';ԕl9X3wn<@ &Oy;"I)HQ ~fdxoB6HcڈY1 `=WO^ ǿD$Rd7]&b6s6GOf[$p4epjƻM3$2yPfG8)pjCmVK{y@QqI15_ :_u[9e)cn.%FI4 ǿptWN☰vqk妵Ҥ%i0s80~o1<MGz쯦X\FrӢ`%Nܞ$ Ӆ-$< NQ@ugB})4}>S{xn~_j)/iGI6F 7=@+O#ieǧȻ]־pvK&V$W'Zy$M5.d//I¢)iGw-^H;FR8%QAG<԰ATҒ}7D1P1[ A5ɧO'K3\4E$nT7bb۰c @>^K圴o4DH2lJ/As֘xti~ײ%2ֳ+ ̥w*FG<7V{F0E+HR4I$Xt 0+~ ڛ]>9tl^_-.Ğc}Xv>^  87|-qmLԖb๷WUeF}(ʚ'_6ƶn^9%K 2= L~(hVclX.;'uԭkGjNg3 qj^Qݥ FXme.W Jz Z@QX\ 𫹔.oKym05e z ~Ju W>AKak|7O)N֍яǾC\Itd9U ;ϥL3SR:s w#U Lmo͌q4.ڥ4"̖Y*8!TxdMJŵҵ8ȸX1,eĠd($m<h N ﶘ0Jt5e#Q_M-t\D `q\̿ nVK絑 đ[1]U|?u{qI [.ۘ4epfNj[Mj=[ݷpv۸.F;UM').؞b)BfP29|>ռagѭX-&xm @!ݷp#OrIiiiyְ^H#prH>$>!Z ,cM҂H.^)"e70p8~?xzm2ME/d6?ٙ>(vy[w8ҳj/OqQ=l M"y8+Ծ^'PMޤM R<I HqC1b֚:j5yU\@*ni|O;&M4"QhDhK39 ڹ |3 uwLWpDXf;1h\ -~^Xc}V2y?(b c-ʕ8#?02`aw'^+ ZUO")d2S NNmn&6cl؉DU*Ė'5kÖ׿jf⼲hFuqs퓏ONDcޱ6ѴEa ,q30iO[tEw. r)ŽLэ4X`]7댏ڎ;E:]ݰ<@|m,ns8|Gм7{e( i#p|8o,676++#|\ǖM N Fp=v?, Y7f%y$)BWq l7|'u?SR[),dܑ)*rzniZcbe6pAotdJVI2G˸`0|ƒj<1qsjI/8I%^x^v`9RyfRtoEv[iw=dl`y%Tn#izK>'E[K"furpF}kF?U`,~(Tƫ@7;hd`ˈ |/>oj~%Vl:)|m-)CPsqQ|âh% Yl){)upʂsYGiA}2ٗ.g$ܜ GEHq5Ć xn|RG*RFF<[YG  Gc-l-n8F;gک? Vؼ-nR##k8P++19C.Ak\KD6VPEPI|3Ju)"Y3j\Y-TקQR3 oKVʰ:F;6ː' Az?ޙikՁKMdS279|SoPo#FCRزv+0+ǎ9>$xWTY G3$Pg(<Y:oBuMmoum &8%iѹ pEʹm`֌_<9q r-̛ʆ`fJ2@j)g׼hUg[*ҧO.Kqݴ,oDј*a\۠7vw32 Mi2)' 揫k iy̡2X` #r3<ӵi:_$m">Rv'\֯5}fU)nnn~ɿ<N@v:Mz_,RJZn@})Pv PR@Q@Q@Q@ J\QE JQLQE&QE ғҊ(BbQE!(`.Q@ KQ@v*@L QEP BL(Q@bB`z 03QE.RRzQE0AIQI \JLJ(!p=QI FҊ(A\JLAEup)0=QAҊ(QLB=(QHQLbzR`zQEOP )p9QE1 KE`Š)uJLJ(!Š((aEPEPEPEP endstream endobj 337 0 obj << /Type /Annot /Subtype /Link /A 338 0 R /Border [0 0 0] /H /I /Rect [ 383.8800 174.7854 393.5173 183.6037 ] >> endobj 338 0 obj << /Type /Action >> endobj 339 0 obj << /Type /Annot /Subtype /Link /A 340 0 R /Border [0 0 0] /H /I /Rect [ 395.9267 174.7854 405.5640 183.6037 ] >> endobj 340 0 obj << /Type /Action >> endobj 341 0 obj << /Type /Annot /Subtype /Link /A 342 0 R /Border [0 0 0] /H /I /Rect [ 315.0938 127.1664 324.7311 135.9847 ] >> endobj 342 0 obj << /Type /Action >> endobj 343 0 obj << /Type /Annot /Subtype /Link /A 344 0 R /Border [0 0 0] /H /I /Rect [ 90.2002 115.2617 99.8376 124.0800 ] >> endobj 344 0 obj << /Type /Action >> endobj 345 0 obj << /Type /Annot /Subtype /Link /A 346 0 R /Border [0 0 0] /H /I /Rect [ 545.4375 95.8569 555.0748 104.6752 ] >> endobj 346 0 obj << /Type /Action >> endobj 347 0 obj << /Type /Annot /Subtype /Link /A 348 0 R /Border [0 0 0] /H /I /Rect [ 52.7993 60.1427 62.4366 68.9610 ] >> endobj 348 0 obj << /Type /Action >> endobj 349 0 obj << /Type /Annot /Subtype /Link /A 350 0 R /Border [0 0 0] /H /I /Rect [ 64.8459 60.1427 74.4833 68.9610 ] >> endobj 350 0 obj << /Type /Action >> endobj 351 0 obj << /Type /Annot /Subtype /Link /A 352 0 R /Border [0 0 0] /H /I /Rect [ 76.8926 60.1427 86.5299 68.9610 ] >> endobj 352 0 obj << /Type /Action >> endobj 353 0 obj << /Type /Annot /Subtype /Link /A 354 0 R /Border [0 0 0] /H /I /Rect [ 88.9393 60.1427 98.5766 68.9610 ] >> endobj 354 0 obj << /Type /Action >> endobj 355 0 obj << /Type /Annot /Subtype /Link /A 356 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 440.9085 485.2500 658.4085 ] >> endobj 356 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/files/2016/11/table-5-HD-0003.jpg) >> endobj 357 0 obj << /Type /Annot /Subtype /Link /A 358 0 R /Border [0 0 0] /H /I /Rect [ 383.8800 174.7854 393.5173 183.6037 ] >> endobj 358 0 obj << /Type /Action >> endobj 359 0 obj << /Type /Annot /Subtype /Link /A 360 0 R /Border [0 0 0] /H /I /Rect [ 395.9267 174.7854 405.5640 183.6037 ] >> endobj 360 0 obj << /Type /Action >> endobj 361 0 obj << /Type /Annot /Subtype /Link /A 362 0 R /Border [0 0 0] /H /I /Rect [ 315.0938 127.1664 324.7311 135.9847 ] >> endobj 362 0 obj << /Type /Action >> endobj 363 0 obj << /Type /Annot /Subtype /Link /A 364 0 R /Border [0 0 0] /H /I /Rect [ 90.2002 115.2617 99.8376 124.0800 ] >> endobj 364 0 obj << /Type /Action >> endobj 365 0 obj << /Type /Annot /Subtype /Link /A 366 0 R /Border [0 0 0] /H /I /Rect [ 545.4375 95.8569 555.0748 104.6752 ] >> endobj 366 0 obj << /Type /Action >> endobj 367 0 obj << /Type /Annot /Subtype /Link /A 368 0 R /Border [0 0 0] /H /I /Rect [ 52.7993 60.1427 62.4366 68.9610 ] >> endobj 368 0 obj << /Type /Action >> endobj 369 0 obj << /Type /Annot /Subtype /Link /A 370 0 R /Border [0 0 0] /H /I /Rect [ 64.8459 60.1427 74.4833 68.9610 ] >> endobj 370 0 obj << /Type /Action >> endobj 371 0 obj << /Type /Annot /Subtype /Link /A 372 0 R /Border [0 0 0] /H /I /Rect [ 76.8926 60.1427 86.5299 68.9610 ] >> endobj 372 0 obj << /Type /Action >> endobj 373 0 obj << /Type /Annot /Subtype /Link /A 374 0 R /Border [0 0 0] /H /I /Rect [ 88.9393 60.1427 98.5766 68.9610 ] >> endobj 374 0 obj << /Type /Action >> endobj 375 0 obj << /Type /Annot /Subtype /Link /A 376 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 440.9085 485.2500 658.4085 ] >> endobj 376 0 obj << /Type /Action /S /URI /URI (https://currents.plos.org/hd/files/2016/11/table-5-HD-0003.jpg) >> endobj 377 0 obj << /Type /Annot /Subtype /Link /A 378 0 R /Border [0 0 0] /H /I /Rect [ 383.8800 174.7854 393.5173 183.6037 ] >> endobj 378 0 obj << /Type /Action >> endobj 379 0 obj << /Type /Annot /Subtype /Link /A 380 0 R /Border [0 0 0] /H /I /Rect [ 395.9267 174.7854 405.5640 183.6037 ] >> endobj 380 0 obj << /Type /Action >> endobj 381 0 obj << /Type /Annot /Subtype /Link /A 382 0 R /Border [0 0 0] /H /I /Rect [ 315.0938 127.1664 324.7311 135.9847 ] >> endobj 382 0 obj << /Type /Action >> endobj 383 0 obj << /Type /Annot /Subtype /Link /A 384 0 R /Border [0 0 0] /H /I /Rect [ 90.2002 115.2617 99.8376 124.0800 ] >> endobj 384 0 obj << /Type /Action >> endobj 385 0 obj << /Type /Annot /Subtype /Link /A 386 0 R /Border [0 0 0] /H /I /Rect [ 545.4375 95.8569 555.0748 104.6752 ] >> endobj 386 0 obj << /Type /Action >> endobj 387 0 obj << /Type /Annot /Subtype /Link /A 388 0 R /Border [0 0 0] /H /I /Rect [ 52.7993 60.1427 62.4366 68.9610 ] >> endobj 388 0 obj << /Type /Action >> endobj 389 0 obj << /Type /Annot /Subtype /Link /A 390 0 R /Border [0 0 0] /H /I /Rect [ 64.8459 60.1427 74.4833 68.9610 ] >> endobj 390 0 obj << /Type /Action >> endobj 391 0 obj << /Type /Annot /Subtype /Link /A 392 0 R /Border [0 0 0] /H /I /Rect [ 76.8926 60.1427 86.5299 68.9610 ] >> endobj 392 0 obj << /Type /Action >> endobj 393 0 obj << /Type /Annot /Subtype /Link /A 394 0 R /Border [0 0 0] /H /I /Rect [ 88.9393 60.1427 98.5766 68.9610 ] >> endobj 394 0 obj << /Type /Action >> endobj 395 0 obj << /Type /Page /Parent 3 0 R /Annots [ 397 0 R 399 0 R 401 0 R 403 0 R 405 0 R 407 0 R 409 0 R 411 0 R 413 0 R 415 0 R 417 0 R 419 0 R 421 0 R 423 0 R 425 0 R 427 0 R 429 0 R 431 0 R 433 0 R 435 0 R 437 0 R 439 0 R 441 0 R 443 0 R 445 0 R 447 0 R 449 0 R 451 0 R 453 0 R 455 0 R 457 0 R 459 0 R 461 0 R 463 0 R 465 0 R 467 0 R 469 0 R 471 0 R 473 0 R 475 0 R 477 0 R 479 0 R 481 0 R 483 0 R 485 0 R 487 0 R 489 0 R 491 0 R 493 0 R 495 0 R 497 0 R 499 0 R 501 0 R 503 0 R 505 0 R 507 0 R 509 0 R 511 0 R 513 0 R 515 0 R 517 0 R 519 0 R 521 0 R 523 0 R 525 0 R 527 0 R ] /Contents 396 0 R >> endobj 396 0 obj << /Length 34606 >> stream 0.271 0.267 0.267 rg q 15.000 25.087 577.500 751.913 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(leading to a state of being comfortably numb. We speculate that an alternative explanation of our results may be that a )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(flattening of affect \(from here on referred to as apathy\) and impaired insight has led to low self-report of psychological distress )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(in our cohort and that this was related to the weaker understanding of others \(i.e. poor social cognitive skills including emotion )] TJ ET BT 26.250 731.762 Td /F1 9.8 Tf [(recognition\).)] TJ ET BT 26.250 712.357 Td /F1 9.8 Tf [(Impaired insight and apathy are well-known features of HD)] TJ ET 0.267 0.267 0.267 rg BT 279.311 713.864 Td /F4 8.7 Tf [(31)] TJ ET 0.271 0.267 0.267 rg BT 288.949 716.245 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 291.358 713.864 Td /F4 8.7 Tf [(38)] TJ ET 0.271 0.267 0.267 rg BT 300.995 716.245 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 303.405 713.864 Td /F4 8.7 Tf [(39)] TJ ET 0.271 0.267 0.267 rg BT 313.042 712.357 Td /F1 9.8 Tf [( and other psychiatric and neurological disorders affecting )] TJ ET BT 26.250 700.452 Td /F1 9.8 Tf [(the prefrontal cortex and frontostriatal circuits such as schizophrenia, PD and FTD. Apathy ratings have been associated with )] TJ ET BT 26.250 688.548 Td /F1 9.8 Tf [(white matter changes in the orbitofrontal cortex in HD, and in both PD and FTD apathy has been associated with areas of the )] TJ ET BT 26.250 676.643 Td /F1 9.8 Tf [(striatum and frontostriatal circuits)] TJ ET 0.267 0.267 0.267 rg BT 169.292 678.150 Td /F4 8.7 Tf [(13)] TJ ET 0.271 0.267 0.267 rg BT 178.930 680.531 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 181.339 678.150 Td /F4 8.7 Tf [(17)] TJ ET 0.271 0.267 0.267 rg BT 190.976 676.643 Td /F1 9.8 Tf [(. In schizophrenia negative symptoms have been inversely associated with striatal )] TJ ET BT 26.250 664.738 Td /F1 9.8 Tf [(activation)] TJ ET 0.267 0.267 0.267 rg BT 67.434 666.245 Td /F4 8.7 Tf [(40)] TJ ET 0.271 0.267 0.267 rg BT 77.071 664.738 Td /F1 9.8 Tf [(. These studies suggest that social cognition, insight and apathy may in part be mediated by overlapping )] TJ ET BT 26.250 652.833 Td /F1 9.8 Tf [(neuroanatomical networks involving the prefrontal cortex and frontostriatal circuits. Thus HD may be a relevant condition in )] TJ ET BT 26.250 640.929 Td /F1 9.8 Tf [(which such associations can be studied.)] TJ ET BT 26.250 621.524 Td /F1 9.8 Tf [(Studies of patients with HD, schizophrenia and FTD suggest a reciprocal relationship between insight and apathy \(or negative )] TJ ET BT 26.250 609.619 Td /F1 9.8 Tf [(symptoms\), such that higher scores of apathy or negative symptoms have been associated with impaired awareness of these )] TJ ET BT 26.250 597.714 Td /F1 9.8 Tf [(symptoms)] TJ ET 0.267 0.267 0.267 rg BT 70.671 599.222 Td /F4 8.7 Tf [(30)] TJ ET 0.271 0.267 0.267 rg BT 80.308 601.603 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 82.718 599.222 Td /F4 8.7 Tf [(41)] TJ ET 0.271 0.267 0.267 rg BT 92.355 601.603 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 94.764 599.222 Td /F4 8.7 Tf [(42)] TJ ET 0.271 0.267 0.267 rg BT 104.402 597.714 Td /F1 9.8 Tf [(. In fact, impaired insight has been associated with better mood in both HD and schizophrenia meaning that )] TJ ET BT 26.250 585.810 Td /F1 9.8 Tf [(patients with less awareness of illness and symptoms has been associated with fewer symptoms of depression, whereas )] TJ ET BT 26.250 573.905 Td /F1 9.8 Tf [(greater self-awareness has been associated with higher depression scores)] TJ ET 0.267 0.267 0.267 rg BT 349.219 575.412 Td /F4 8.7 Tf [(14)] TJ ET 0.271 0.267 0.267 rg BT 358.856 577.793 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 361.265 575.412 Td /F4 8.7 Tf [(42)] TJ ET 0.271 0.267 0.267 rg BT 370.903 577.793 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 373.312 575.412 Td /F4 8.7 Tf [(43)] TJ ET 0.271 0.267 0.267 rg BT 382.949 577.793 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 385.359 575.412 Td /F4 8.7 Tf [(44)] TJ ET 0.271 0.267 0.267 rg BT 394.996 573.905 Td /F1 9.8 Tf [(. These findings support the view that )] TJ ET BT 26.250 562.000 Td /F1 9.8 Tf [(apathy and lack of insight are closely connected and they also point in the direction of patients with symptoms of apathy being )] TJ ET BT 26.250 550.095 Td /F1 9.8 Tf [(expected also to have poor self-awareness and therefore to report neither apathetic symptoms nor psychological distress in )] TJ ET BT 26.250 538.191 Td /F1 9.8 Tf [(general.)] TJ ET BT 26.250 518.786 Td /F1 9.8 Tf [(Impaired insight and higher apathy scores have been found to be associated with worse performances on social cognitive tests )] TJ ET BT 26.250 506.881 Td /F1 9.8 Tf [(in FTD, PD and schizophrenia)] TJ ET 0.267 0.267 0.267 rg BT 156.296 508.388 Td /F4 8.7 Tf [(13)] TJ ET 0.271 0.267 0.267 rg BT 165.933 510.769 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 168.342 508.388 Td /F4 8.7 Tf [(41)] TJ ET 0.271 0.267 0.267 rg BT 177.980 510.769 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 180.389 508.388 Td /F4 8.7 Tf [(42)] TJ ET 0.271 0.267 0.267 rg BT 190.026 510.769 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 192.436 508.388 Td /F4 8.7 Tf [(45)] TJ ET 0.271 0.267 0.267 rg BT 202.073 510.769 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 204.482 508.388 Td /F4 8.7 Tf [(46)] TJ ET 0.271 0.267 0.267 rg BT 214.120 506.881 Td /F1 9.8 Tf [(. One study in FTD found that patients own ratings of apathy were positively )] TJ ET BT 26.250 494.976 Td /F1 9.8 Tf [(correlated to ToM whereas the caregivers apathy ratings were negatively associated with ToM performance)] TJ ET 0.267 0.267 0.267 rg BT 491.715 496.484 Td /F4 8.7 Tf [(13)] TJ ET 0.271 0.267 0.267 rg BT 501.352 494.976 Td /F1 9.8 Tf [(, indicating that )] TJ ET BT 26.250 483.072 Td /F1 9.8 Tf [(greater awareness of apathetic symptoms was associated with better social cognitive skills. This finding may reflect the close )] TJ ET BT 26.250 471.167 Td /F1 9.8 Tf [(connection between representations of the self and other and is in line with our results indicating that patients with better self-)] TJ ET BT 26.250 459.262 Td /F1 9.8 Tf [(awareness also have a better understanding of others emotional states and vice versa. We found no associations between self-)] TJ ET BT 26.250 447.357 Td /F1 9.8 Tf [(report of psychological distress and performance on tests of executive functions. This was somewhat surprising since )] TJ ET BT 26.250 435.453 Td /F1 9.8 Tf [(psychiatric symptoms such as depression has often been associated to impairment in executive functions. There may be )] TJ ET BT 26.250 423.548 Td /F1 9.8 Tf [(several different explanations for this finding. It may be that the tests used in this study are not sensitive to the type of executive )] TJ ET BT 26.250 411.643 Td /F1 9.8 Tf [(dysfunction associated with psychiatric symptoms. It could also be that the types of psychiatric symptoms that are associated )] TJ ET BT 26.250 399.738 Td /F1 9.8 Tf [(with executive dysfunctions are not well measured by the SCL-90-R. In a study by Thompson et al. )] TJ ET 0.267 0.267 0.267 rg BT 454.353 401.246 Td /F4 8.7 Tf [(47)] TJ ET 0.271 0.267 0.267 rg BT 463.990 399.738 Td /F1 9.8 Tf [( they found that only )] TJ ET BT 26.250 387.834 Td /F1 9.8 Tf [(apathy was significantly associated with impairment in executive functions in HD.)] TJ ET BT 26.250 368.429 Td /F1 9.8 Tf [(No other studies that we know of have found significant correlations between self-report of psychological distress and )] TJ ET BT 26.250 356.524 Td /F1 9.8 Tf [(performance on social cognitive tests in HD. Two studies have investigated the correlation between alexithymia and emotion )] TJ ET BT 26.250 344.619 Td /F1 9.8 Tf [(recognition and ToM in HD but found no significant correlations)] TJ ET 0.267 0.267 0.267 rg BT 298.285 346.127 Td /F4 8.7 Tf [(48)] TJ ET 0.271 0.267 0.267 rg BT 307.922 344.619 Td /F1 9.8 Tf [(, and one other study found no significant associations )] TJ ET BT 26.250 332.715 Td /F1 9.8 Tf [(between performance on a ToM task and psychiatric symptoms on the Positive And Negative Syndrome Scale in HD)] TJ ET 0.267 0.267 0.267 rg BT 529.116 334.222 Td /F4 8.7 Tf [(49)] TJ ET 0.271 0.267 0.267 rg BT 538.753 332.715 Td /F1 9.8 Tf [(. )] TJ ET BT 26.250 320.810 Td /F1 9.8 Tf [(Discrepancies between our results and previous findings may be explained by different methodological approaches, and these )] TJ ET BT 26.250 308.905 Td /F1 9.8 Tf [(previous studies had small sample sizes compared to our study.)] TJ ET BT 26.250 289.500 Td /F4 9.8 Tf [(Limitations)] TJ ET BT 26.250 270.096 Td /F1 9.8 Tf [(There are several limitations to our study. In an exploratory study like this was, there can be quite a lot of statistical comparisons )] TJ ET BT 26.250 258.191 Td /F1 9.8 Tf [(and thus a chance of false positive findings. The use of a self-report measure of perceived psychological distress may have )] TJ ET BT 26.250 246.286 Td /F1 9.8 Tf [(been misleading, since some HD patients are known to show poor awareness of their symptoms. Future research should add )] TJ ET BT 26.250 234.381 Td /F1 9.8 Tf [(ratings from caregivers or clinicians to overcome this problem and to get more information about the relationship between social )] TJ ET BT 26.250 222.477 Td /F1 9.8 Tf [(cognitive performances and insight in HD. Also an apathy rating scale or a scale for rating negative symptoms, would have )] TJ ET BT 26.250 210.572 Td /F1 9.8 Tf [(helped to clarify the mechanisms for our findings. Future studies should apply apathy ratings to investigate the association )] TJ ET BT 26.250 198.667 Td /F1 9.8 Tf [(between social cognition and apathy in HD.)] TJ ET BT 26.250 179.262 Td /F1 9.8 Tf [(Other limitations to the study relate to the tests used. The Danish version of TASIT was developed for research purposes and it )] TJ ET BT 26.250 167.358 Td /F1 9.8 Tf [(has not been standardized and validated. This must, of course, lead to caution when interpreting results. Sarcasm as a part of )] TJ ET BT 26.250 155.453 Td /F1 9.8 Tf [(everyday interaction is somewhat culture specific and thus generalization to all other cultures may be limited. The EET of the )] TJ ET BT 26.250 143.548 Td /F1 9.8 Tf [(TASIT does not exist in a Danish version and thus was used without sound. The clinical impression of performances on this test )] TJ ET BT 26.250 131.643 Td /F1 9.8 Tf [(was that it was still meaningful and there were no significant differences between healthy controls and premanifest HD carriers )] TJ ET BT 26.250 119.739 Td /F1 9.8 Tf [(on performances on the EET in a previously published study \(ref\). Although our evaluation was that the test was still meaningful, )] TJ ET BT 26.250 107.834 Td /F1 9.8 Tf [(the different use of the test from its original form requires caution when interpreting the results.)] TJ ET BT 26.250 71.231 Td /F4 12.0 Tf [(Conclusions)] TJ ET BT 26.250 51.277 Td /F1 9.8 Tf [(We found significant associations between self-report of psychological distress and performances on social cognitive tests but )] TJ ET BT 26.250 39.372 Td /F1 9.8 Tf [(not on tests of executive functions. According to our findings HD patients that feel less psychologically distressed themselves )] TJ ET Q q 15.000 25.087 577.500 751.913 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(leading to a state of being comfortably numb. We speculate that an alternative explanation of our results may be that a )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(flattening of affect \(from here on referred to as apathy\) and impaired insight has led to low self-report of psychological distress )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(in our cohort and that this was related to the weaker understanding of others \(i.e. poor social cognitive skills including emotion )] TJ ET BT 26.250 731.762 Td /F1 9.8 Tf [(recognition\).)] TJ ET BT 26.250 712.357 Td /F1 9.8 Tf [(Impaired insight and apathy are well-known features of HD)] TJ ET 0.267 0.267 0.267 rg BT 279.311 713.864 Td /F4 8.7 Tf [(31)] TJ ET 0.271 0.267 0.267 rg BT 288.949 716.245 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 291.358 713.864 Td /F4 8.7 Tf [(38)] TJ ET 0.271 0.267 0.267 rg BT 300.995 716.245 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 303.405 713.864 Td /F4 8.7 Tf [(39)] TJ ET 0.271 0.267 0.267 rg BT 313.042 712.357 Td /F1 9.8 Tf [( and other psychiatric and neurological disorders affecting )] TJ ET BT 26.250 700.452 Td /F1 9.8 Tf [(the prefrontal cortex and frontostriatal circuits such as schizophrenia, PD and FTD. Apathy ratings have been associated with )] TJ ET BT 26.250 688.548 Td /F1 9.8 Tf [(white matter changes in the orbitofrontal cortex in HD, and in both PD and FTD apathy has been associated with areas of the )] TJ ET BT 26.250 676.643 Td /F1 9.8 Tf [(striatum and frontostriatal circuits)] TJ ET 0.267 0.267 0.267 rg BT 169.292 678.150 Td /F4 8.7 Tf [(13)] TJ ET 0.271 0.267 0.267 rg BT 178.930 680.531 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 181.339 678.150 Td /F4 8.7 Tf [(17)] TJ ET 0.271 0.267 0.267 rg BT 190.976 676.643 Td /F1 9.8 Tf [(. In schizophrenia negative symptoms have been inversely associated with striatal )] TJ ET BT 26.250 664.738 Td /F1 9.8 Tf [(activation)] TJ ET 0.267 0.267 0.267 rg BT 67.434 666.245 Td /F4 8.7 Tf [(40)] TJ ET 0.271 0.267 0.267 rg BT 77.071 664.738 Td /F1 9.8 Tf [(. These studies suggest that social cognition, insight and apathy may in part be mediated by overlapping )] TJ ET BT 26.250 652.833 Td /F1 9.8 Tf [(neuroanatomical networks involving the prefrontal cortex and frontostriatal circuits. Thus HD may be a relevant condition in )] TJ ET BT 26.250 640.929 Td /F1 9.8 Tf [(which such associations can be studied.)] TJ ET BT 26.250 621.524 Td /F1 9.8 Tf [(Studies of patients with HD, schizophrenia and FTD suggest a reciprocal relationship between insight and apathy \(or negative )] TJ ET BT 26.250 609.619 Td /F1 9.8 Tf [(symptoms\), such that higher scores of apathy or negative symptoms have been associated with impaired awareness of these )] TJ ET BT 26.250 597.714 Td /F1 9.8 Tf [(symptoms)] TJ ET 0.267 0.267 0.267 rg BT 70.671 599.222 Td /F4 8.7 Tf [(30)] TJ ET 0.271 0.267 0.267 rg BT 80.308 601.603 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 82.718 599.222 Td /F4 8.7 Tf [(41)] TJ ET 0.271 0.267 0.267 rg BT 92.355 601.603 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 94.764 599.222 Td /F4 8.7 Tf [(42)] TJ ET 0.271 0.267 0.267 rg BT 104.402 597.714 Td /F1 9.8 Tf [(. In fact, impaired insight has been associated with better mood in both HD and schizophrenia meaning that )] TJ ET BT 26.250 585.810 Td /F1 9.8 Tf [(patients with less awareness of illness and symptoms has been associated with fewer symptoms of depression, whereas )] TJ ET BT 26.250 573.905 Td /F1 9.8 Tf [(greater self-awareness has been associated with higher depression scores)] TJ ET 0.267 0.267 0.267 rg BT 349.219 575.412 Td /F4 8.7 Tf [(14)] TJ ET 0.271 0.267 0.267 rg BT 358.856 577.793 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 361.265 575.412 Td /F4 8.7 Tf [(42)] TJ ET 0.271 0.267 0.267 rg BT 370.903 577.793 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 373.312 575.412 Td /F4 8.7 Tf [(43)] TJ ET 0.271 0.267 0.267 rg BT 382.949 577.793 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 385.359 575.412 Td /F4 8.7 Tf [(44)] TJ ET 0.271 0.267 0.267 rg BT 394.996 573.905 Td /F1 9.8 Tf [(. These findings support the view that )] TJ ET BT 26.250 562.000 Td /F1 9.8 Tf [(apathy and lack of insight are closely connected and they also point in the direction of patients with symptoms of apathy being )] TJ ET BT 26.250 550.095 Td /F1 9.8 Tf [(expected also to have poor self-awareness and therefore to report neither apathetic symptoms nor psychological distress in )] TJ ET BT 26.250 538.191 Td /F1 9.8 Tf [(general.)] TJ ET BT 26.250 518.786 Td /F1 9.8 Tf [(Impaired insight and higher apathy scores have been found to be associated with worse performances on social cognitive tests )] TJ ET BT 26.250 506.881 Td /F1 9.8 Tf [(in FTD, PD and schizophrenia)] TJ ET 0.267 0.267 0.267 rg BT 156.296 508.388 Td /F4 8.7 Tf [(13)] TJ ET 0.271 0.267 0.267 rg BT 165.933 510.769 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 168.342 508.388 Td /F4 8.7 Tf [(41)] TJ ET 0.271 0.267 0.267 rg BT 177.980 510.769 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 180.389 508.388 Td /F4 8.7 Tf [(42)] TJ ET 0.271 0.267 0.267 rg BT 190.026 510.769 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 192.436 508.388 Td /F4 8.7 Tf [(45)] TJ ET 0.271 0.267 0.267 rg BT 202.073 510.769 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 204.482 508.388 Td /F4 8.7 Tf [(46)] TJ ET 0.271 0.267 0.267 rg BT 214.120 506.881 Td /F1 9.8 Tf [(. One study in FTD found that patients own ratings of apathy were positively )] TJ ET BT 26.250 494.976 Td /F1 9.8 Tf [(correlated to ToM whereas the caregivers apathy ratings were negatively associated with ToM performance)] TJ ET 0.267 0.267 0.267 rg BT 491.715 496.484 Td /F4 8.7 Tf [(13)] TJ ET 0.271 0.267 0.267 rg BT 501.352 494.976 Td /F1 9.8 Tf [(, indicating that )] TJ ET BT 26.250 483.072 Td /F1 9.8 Tf [(greater awareness of apathetic symptoms was associated with better social cognitive skills. This finding may reflect the close )] TJ ET BT 26.250 471.167 Td /F1 9.8 Tf [(connection between representations of the self and other and is in line with our results indicating that patients with better self-)] TJ ET BT 26.250 459.262 Td /F1 9.8 Tf [(awareness also have a better understanding of others emotional states and vice versa. We found no associations between self-)] TJ ET BT 26.250 447.357 Td /F1 9.8 Tf [(report of psychological distress and performance on tests of executive functions. This was somewhat surprising since )] TJ ET BT 26.250 435.453 Td /F1 9.8 Tf [(psychiatric symptoms such as depression has often been associated to impairment in executive functions. There may be )] TJ ET BT 26.250 423.548 Td /F1 9.8 Tf [(several different explanations for this finding. It may be that the tests used in this study are not sensitive to the type of executive )] TJ ET BT 26.250 411.643 Td /F1 9.8 Tf [(dysfunction associated with psychiatric symptoms. It could also be that the types of psychiatric symptoms that are associated )] TJ ET BT 26.250 399.738 Td /F1 9.8 Tf [(with executive dysfunctions are not well measured by the SCL-90-R. In a study by Thompson et al. )] TJ ET 0.267 0.267 0.267 rg BT 454.353 401.246 Td /F4 8.7 Tf [(47)] TJ ET 0.271 0.267 0.267 rg BT 463.990 399.738 Td /F1 9.8 Tf [( they found that only )] TJ ET BT 26.250 387.834 Td /F1 9.8 Tf [(apathy was significantly associated with impairment in executive functions in HD.)] TJ ET BT 26.250 368.429 Td /F1 9.8 Tf [(No other studies that we know of have found significant correlations between self-report of psychological distress and )] TJ ET BT 26.250 356.524 Td /F1 9.8 Tf [(performance on social cognitive tests in HD. Two studies have investigated the correlation between alexithymia and emotion )] TJ ET BT 26.250 344.619 Td /F1 9.8 Tf [(recognition and ToM in HD but found no significant correlations)] TJ ET 0.267 0.267 0.267 rg BT 298.285 346.127 Td /F4 8.7 Tf [(48)] TJ ET 0.271 0.267 0.267 rg BT 307.922 344.619 Td /F1 9.8 Tf [(, and one other study found no significant associations )] TJ ET BT 26.250 332.715 Td /F1 9.8 Tf [(between performance on a ToM task and psychiatric symptoms on the Positive And Negative Syndrome Scale in HD)] TJ ET 0.267 0.267 0.267 rg BT 529.116 334.222 Td /F4 8.7 Tf [(49)] TJ ET 0.271 0.267 0.267 rg BT 538.753 332.715 Td /F1 9.8 Tf [(. )] TJ ET BT 26.250 320.810 Td /F1 9.8 Tf [(Discrepancies between our results and previous findings may be explained by different methodological approaches, and these )] TJ ET BT 26.250 308.905 Td /F1 9.8 Tf [(previous studies had small sample sizes compared to our study.)] TJ ET BT 26.250 289.500 Td /F4 9.8 Tf [(Limitations)] TJ ET BT 26.250 270.096 Td /F1 9.8 Tf [(There are several limitations to our study. In an exploratory study like this was, there can be quite a lot of statistical comparisons )] TJ ET BT 26.250 258.191 Td /F1 9.8 Tf [(and thus a chance of false positive findings. The use of a self-report measure of perceived psychological distress may have )] TJ ET BT 26.250 246.286 Td /F1 9.8 Tf [(been misleading, since some HD patients are known to show poor awareness of their symptoms. Future research should add )] TJ ET BT 26.250 234.381 Td /F1 9.8 Tf [(ratings from caregivers or clinicians to overcome this problem and to get more information about the relationship between social )] TJ ET BT 26.250 222.477 Td /F1 9.8 Tf [(cognitive performances and insight in HD. Also an apathy rating scale or a scale for rating negative symptoms, would have )] TJ ET BT 26.250 210.572 Td /F1 9.8 Tf [(helped to clarify the mechanisms for our findings. Future studies should apply apathy ratings to investigate the association )] TJ ET BT 26.250 198.667 Td /F1 9.8 Tf [(between social cognition and apathy in HD.)] TJ ET BT 26.250 179.262 Td /F1 9.8 Tf [(Other limitations to the study relate to the tests used. The Danish version of TASIT was developed for research purposes and it )] TJ ET BT 26.250 167.358 Td /F1 9.8 Tf [(has not been standardized and validated. This must, of course, lead to caution when interpreting results. Sarcasm as a part of )] TJ ET BT 26.250 155.453 Td /F1 9.8 Tf [(everyday interaction is somewhat culture specific and thus generalization to all other cultures may be limited. The EET of the )] TJ ET BT 26.250 143.548 Td /F1 9.8 Tf [(TASIT does not exist in a Danish version and thus was used without sound. The clinical impression of performances on this test )] TJ ET BT 26.250 131.643 Td /F1 9.8 Tf [(was that it was still meaningful and there were no significant differences between healthy controls and premanifest HD carriers )] TJ ET BT 26.250 119.739 Td /F1 9.8 Tf [(on performances on the EET in a previously published study \(ref\). Although our evaluation was that the test was still meaningful, )] TJ ET BT 26.250 107.834 Td /F1 9.8 Tf [(the different use of the test from its original form requires caution when interpreting the results.)] TJ ET BT 26.250 71.231 Td /F4 12.0 Tf [(Conclusions)] TJ ET BT 26.250 51.277 Td /F1 9.8 Tf [(We found significant associations between self-report of psychological distress and performances on social cognitive tests but )] TJ ET BT 26.250 39.372 Td /F1 9.8 Tf [(not on tests of executive functions. According to our findings HD patients that feel less psychologically distressed themselves )] TJ ET Q q 15.000 25.087 577.500 751.913 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(leading to a state of being comfortably numb. We speculate that an alternative explanation of our results may be that a )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(flattening of affect \(from here on referred to as apathy\) and impaired insight has led to low self-report of psychological distress )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(in our cohort and that this was related to the weaker understanding of others \(i.e. poor social cognitive skills including emotion )] TJ ET BT 26.250 731.762 Td /F1 9.8 Tf [(recognition\).)] TJ ET BT 26.250 712.357 Td /F1 9.8 Tf [(Impaired insight and apathy are well-known features of HD)] TJ ET 0.267 0.267 0.267 rg BT 279.311 713.864 Td /F4 8.7 Tf [(31)] TJ ET 0.271 0.267 0.267 rg BT 288.949 716.245 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 291.358 713.864 Td /F4 8.7 Tf [(38)] TJ ET 0.271 0.267 0.267 rg BT 300.995 716.245 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 303.405 713.864 Td /F4 8.7 Tf [(39)] TJ ET 0.271 0.267 0.267 rg BT 313.042 712.357 Td /F1 9.8 Tf [( and other psychiatric and neurological disorders affecting )] TJ ET BT 26.250 700.452 Td /F1 9.8 Tf [(the prefrontal cortex and frontostriatal circuits such as schizophrenia, PD and FTD. Apathy ratings have been associated with )] TJ ET BT 26.250 688.548 Td /F1 9.8 Tf [(white matter changes in the orbitofrontal cortex in HD, and in both PD and FTD apathy has been associated with areas of the )] TJ ET BT 26.250 676.643 Td /F1 9.8 Tf [(striatum and frontostriatal circuits)] TJ ET 0.267 0.267 0.267 rg BT 169.292 678.150 Td /F4 8.7 Tf [(13)] TJ ET 0.271 0.267 0.267 rg BT 178.930 680.531 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 181.339 678.150 Td /F4 8.7 Tf [(17)] TJ ET 0.271 0.267 0.267 rg BT 190.976 676.643 Td /F1 9.8 Tf [(. In schizophrenia negative symptoms have been inversely associated with striatal )] TJ ET BT 26.250 664.738 Td /F1 9.8 Tf [(activation)] TJ ET 0.267 0.267 0.267 rg BT 67.434 666.245 Td /F4 8.7 Tf [(40)] TJ ET 0.271 0.267 0.267 rg BT 77.071 664.738 Td /F1 9.8 Tf [(. These studies suggest that social cognition, insight and apathy may in part be mediated by overlapping )] TJ ET BT 26.250 652.833 Td /F1 9.8 Tf [(neuroanatomical networks involving the prefrontal cortex and frontostriatal circuits. Thus HD may be a relevant condition in )] TJ ET BT 26.250 640.929 Td /F1 9.8 Tf [(which such associations can be studied.)] TJ ET BT 26.250 621.524 Td /F1 9.8 Tf [(Studies of patients with HD, schizophrenia and FTD suggest a reciprocal relationship between insight and apathy \(or negative )] TJ ET BT 26.250 609.619 Td /F1 9.8 Tf [(symptoms\), such that higher scores of apathy or negative symptoms have been associated with impaired awareness of these )] TJ ET BT 26.250 597.714 Td /F1 9.8 Tf [(symptoms)] TJ ET 0.267 0.267 0.267 rg BT 70.671 599.222 Td /F4 8.7 Tf [(30)] TJ ET 0.271 0.267 0.267 rg BT 80.308 601.603 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 82.718 599.222 Td /F4 8.7 Tf [(41)] TJ ET 0.271 0.267 0.267 rg BT 92.355 601.603 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 94.764 599.222 Td /F4 8.7 Tf [(42)] TJ ET 0.271 0.267 0.267 rg BT 104.402 597.714 Td /F1 9.8 Tf [(. In fact, impaired insight has been associated with better mood in both HD and schizophrenia meaning that )] TJ ET BT 26.250 585.810 Td /F1 9.8 Tf [(patients with less awareness of illness and symptoms has been associated with fewer symptoms of depression, whereas )] TJ ET BT 26.250 573.905 Td /F1 9.8 Tf [(greater self-awareness has been associated with higher depression scores)] TJ ET 0.267 0.267 0.267 rg BT 349.219 575.412 Td /F4 8.7 Tf [(14)] TJ ET 0.271 0.267 0.267 rg BT 358.856 577.793 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 361.265 575.412 Td /F4 8.7 Tf [(42)] TJ ET 0.271 0.267 0.267 rg BT 370.903 577.793 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 373.312 575.412 Td /F4 8.7 Tf [(43)] TJ ET 0.271 0.267 0.267 rg BT 382.949 577.793 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 385.359 575.412 Td /F4 8.7 Tf [(44)] TJ ET 0.271 0.267 0.267 rg BT 394.996 573.905 Td /F1 9.8 Tf [(. These findings support the view that )] TJ ET BT 26.250 562.000 Td /F1 9.8 Tf [(apathy and lack of insight are closely connected and they also point in the direction of patients with symptoms of apathy being )] TJ ET BT 26.250 550.095 Td /F1 9.8 Tf [(expected also to have poor self-awareness and therefore to report neither apathetic symptoms nor psychological distress in )] TJ ET BT 26.250 538.191 Td /F1 9.8 Tf [(general.)] TJ ET BT 26.250 518.786 Td /F1 9.8 Tf [(Impaired insight and higher apathy scores have been found to be associated with worse performances on social cognitive tests )] TJ ET BT 26.250 506.881 Td /F1 9.8 Tf [(in FTD, PD and schizophrenia)] TJ ET 0.267 0.267 0.267 rg BT 156.296 508.388 Td /F4 8.7 Tf [(13)] TJ ET 0.271 0.267 0.267 rg BT 165.933 510.769 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 168.342 508.388 Td /F4 8.7 Tf [(41)] TJ ET 0.271 0.267 0.267 rg BT 177.980 510.769 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 180.389 508.388 Td /F4 8.7 Tf [(42)] TJ ET 0.271 0.267 0.267 rg BT 190.026 510.769 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 192.436 508.388 Td /F4 8.7 Tf [(45)] TJ ET 0.271 0.267 0.267 rg BT 202.073 510.769 Td /F1 8.7 Tf [(,)] TJ ET 0.267 0.267 0.267 rg BT 204.482 508.388 Td /F4 8.7 Tf [(46)] TJ ET 0.271 0.267 0.267 rg BT 214.120 506.881 Td /F1 9.8 Tf [(. One study in FTD found that patients own ratings of apathy were positively )] TJ ET BT 26.250 494.976 Td /F1 9.8 Tf [(correlated to ToM whereas the caregivers apathy ratings were negatively associated with ToM performance)] TJ ET 0.267 0.267 0.267 rg BT 491.715 496.484 Td /F4 8.7 Tf [(13)] TJ ET 0.271 0.267 0.267 rg BT 501.352 494.976 Td /F1 9.8 Tf [(, indicating that )] TJ ET BT 26.250 483.072 Td /F1 9.8 Tf [(greater awareness of apathetic symptoms was associated with better social cognitive skills. This finding may reflect the close )] TJ ET BT 26.250 471.167 Td /F1 9.8 Tf [(connection between representations of the self and other and is in line with our results indicating that patients with better self-)] TJ ET BT 26.250 459.262 Td /F1 9.8 Tf [(awareness also have a better understanding of others emotional states and vice versa. We found no associations between self-)] TJ ET BT 26.250 447.357 Td /F1 9.8 Tf [(report of psychological distress and performance on tests of executive functions. This was somewhat surprising since )] TJ ET BT 26.250 435.453 Td /F1 9.8 Tf [(psychiatric symptoms such as depression has often been associated to impairment in executive functions. There may be )] TJ ET BT 26.250 423.548 Td /F1 9.8 Tf [(several different explanations for this finding. It may be that the tests used in this study are not sensitive to the type of executive )] TJ ET BT 26.250 411.643 Td /F1 9.8 Tf [(dysfunction associated with psychiatric symptoms. It could also be that the types of psychiatric symptoms that are associated )] TJ ET BT 26.250 399.738 Td /F1 9.8 Tf [(with executive dysfunctions are not well measured by the SCL-90-R. In a study by Thompson et al. )] TJ ET 0.267 0.267 0.267 rg BT 454.353 401.246 Td /F4 8.7 Tf [(47)] TJ ET 0.271 0.267 0.267 rg BT 463.990 399.738 Td /F1 9.8 Tf [( they found that only )] TJ ET BT 26.250 387.834 Td /F1 9.8 Tf [(apathy was significantly associated with impairment in executive functions in HD.)] TJ ET BT 26.250 368.429 Td /F1 9.8 Tf [(No other studies that we know of have found significant correlations between self-report of psychological distress and )] TJ ET BT 26.250 356.524 Td /F1 9.8 Tf [(performance on social cognitive tests in HD. Two studies have investigated the correlation between alexithymia and emotion )] TJ ET BT 26.250 344.619 Td /F1 9.8 Tf [(recognition and ToM in HD but found no significant correlations)] TJ ET 0.267 0.267 0.267 rg BT 298.285 346.127 Td /F4 8.7 Tf [(48)] TJ ET 0.271 0.267 0.267 rg BT 307.922 344.619 Td /F1 9.8 Tf [(, and one other study found no significant associations )] TJ ET BT 26.250 332.715 Td /F1 9.8 Tf [(between performance on a ToM task and psychiatric symptoms on the Positive And Negative Syndrome Scale in HD)] TJ ET 0.267 0.267 0.267 rg BT 529.116 334.222 Td /F4 8.7 Tf [(49)] TJ ET 0.271 0.267 0.267 rg BT 538.753 332.715 Td /F1 9.8 Tf [(. )] TJ ET BT 26.250 320.810 Td /F1 9.8 Tf [(Discrepancies between our results and previous findings may be explained by different methodological approaches, and these )] TJ ET BT 26.250 308.905 Td /F1 9.8 Tf [(previous studies had small sample sizes compared to our study.)] TJ ET BT 26.250 289.500 Td /F4 9.8 Tf [(Limitations)] TJ ET BT 26.250 270.096 Td /F1 9.8 Tf [(There are several limitations to our study. In an exploratory study like this was, there can be quite a lot of statistical comparisons )] TJ ET BT 26.250 258.191 Td /F1 9.8 Tf [(and thus a chance of false positive findings. The use of a self-report measure of perceived psychological distress may have )] TJ ET BT 26.250 246.286 Td /F1 9.8 Tf [(been misleading, since some HD patients are known to show poor awareness of their symptoms. Future research should add )] TJ ET BT 26.250 234.381 Td /F1 9.8 Tf [(ratings from caregivers or clinicians to overcome this problem and to get more information about the relationship between social )] TJ ET BT 26.250 222.477 Td /F1 9.8 Tf [(cognitive performances and insight in HD. Also an apathy rating scale or a scale for rating negative symptoms, would have )] TJ ET BT 26.250 210.572 Td /F1 9.8 Tf [(helped to clarify the mechanisms for our findings. Future studies should apply apathy ratings to investigate the association )] TJ ET BT 26.250 198.667 Td /F1 9.8 Tf [(between social cognition and apathy in HD.)] TJ ET BT 26.250 179.262 Td /F1 9.8 Tf [(Other limitations to the study relate to the tests used. The Danish version of TASIT was developed for research purposes and it )] TJ ET BT 26.250 167.358 Td /F1 9.8 Tf [(has not been standardized and validated. This must, of course, lead to caution when interpreting results. Sarcasm as a part of )] TJ ET BT 26.250 155.453 Td /F1 9.8 Tf [(everyday interaction is somewhat culture specific and thus generalization to all other cultures may be limited. The EET of the )] TJ ET BT 26.250 143.548 Td /F1 9.8 Tf [(TASIT does not exist in a Danish version and thus was used without sound. The clinical impression of performances on this test )] TJ ET BT 26.250 131.643 Td /F1 9.8 Tf [(was that it was still meaningful and there were no significant differences between healthy controls and premanifest HD carriers )] TJ ET BT 26.250 119.739 Td /F1 9.8 Tf [(on performances on the EET in a previously published study \(ref\). Although our evaluation was that the test was still meaningful, )] TJ ET BT 26.250 107.834 Td /F1 9.8 Tf [(the different use of the test from its original form requires caution when interpreting the results.)] TJ ET BT 26.250 71.231 Td /F4 12.0 Tf [(Conclusions)] TJ ET BT 26.250 51.277 Td /F1 9.8 Tf [(We found significant associations between self-report of psychological distress and performances on social cognitive tests but )] TJ ET BT 26.250 39.372 Td /F1 9.8 Tf [(not on tests of executive functions. According to our findings HD patients that feel less psychologically distressed themselves )] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(7)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Huntington Disease)] TJ ET Q endstream endobj 397 0 obj << /Type /Annot /Subtype /Link /A 398 0 R /Border [0 0 0] /H /I /Rect [ 279.3112 713.0627 288.9486 721.8810 ] >> endobj 398 0 obj << /Type /Action >> endobj 399 0 obj << /Type /Annot /Subtype /Link /A 400 0 R /Border [0 0 0] /H /I /Rect [ 291.3579 713.0627 300.9953 721.8810 ] >> endobj 400 0 obj << /Type /Action >> endobj 401 0 obj << /Type /Annot /Subtype /Link /A 402 0 R /Border [0 0 0] /H /I /Rect [ 303.4046 713.0627 313.0419 721.8810 ] >> endobj 402 0 obj << /Type /Action >> endobj 403 0 obj << /Type /Annot /Subtype /Link /A 404 0 R /Border [0 0 0] /H /I /Rect [ 169.2922 677.3484 178.9296 686.1667 ] >> endobj 404 0 obj << /Type /Action >> endobj 405 0 obj << /Type /Annot /Subtype /Link /A 406 0 R /Border [0 0 0] /H /I /Rect [ 181.3389 677.3484 190.9763 686.1667 ] >> endobj 406 0 obj << /Type /Action >> endobj 407 0 obj << /Type /Annot /Subtype /Link /A 408 0 R /Border [0 0 0] /H /I /Rect [ 67.4340 665.4437 77.0713 674.2620 ] >> endobj 408 0 obj << /Type /Action >> endobj 409 0 obj << /Type /Annot /Subtype /Link /A 410 0 R /Border [0 0 0] /H /I /Rect [ 70.6710 598.4199 80.3083 607.2382 ] >> endobj 410 0 obj << /Type /Action >> endobj 411 0 obj << /Type /Annot /Subtype /Link /A 412 0 R /Border [0 0 0] /H /I /Rect [ 82.7177 598.4199 92.3550 607.2382 ] >> endobj 412 0 obj << /Type /Action >> endobj 413 0 obj << /Type /Annot /Subtype /Link /A 414 0 R /Border [0 0 0] /H /I /Rect [ 94.7643 598.4199 104.4017 607.2382 ] >> endobj 414 0 obj << /Type /Action >> endobj 415 0 obj << /Type /Annot /Subtype /Link /A 416 0 R /Border [0 0 0] /H /I /Rect [ 349.2188 574.6104 358.8561 583.4287 ] >> endobj 416 0 obj << /Type /Action >> endobj 417 0 obj << /Type /Annot /Subtype /Link /A 418 0 R /Border [0 0 0] /H /I /Rect [ 361.2654 574.6104 370.9028 583.4287 ] >> endobj 418 0 obj << /Type /Action >> endobj 419 0 obj << /Type /Annot /Subtype /Link /A 420 0 R /Border [0 0 0] /H /I /Rect [ 373.3121 574.6104 382.9494 583.4287 ] >> endobj 420 0 obj << /Type /Action >> endobj 421 0 obj << /Type /Annot /Subtype /Link /A 422 0 R /Border [0 0 0] /H /I /Rect [ 385.3588 574.6104 394.9961 583.4287 ] >> endobj 422 0 obj << /Type /Action >> endobj 423 0 obj << /Type /Annot /Subtype /Link /A 424 0 R /Border [0 0 0] /H /I /Rect [ 156.2955 507.5867 165.9328 516.4050 ] >> endobj 424 0 obj << /Type /Action >> endobj 425 0 obj << /Type /Annot /Subtype /Link /A 426 0 R /Border [0 0 0] /H /I /Rect [ 168.3422 507.5867 177.9795 516.4050 ] >> endobj 426 0 obj << /Type /Action >> endobj 427 0 obj << /Type /Annot /Subtype /Link /A 428 0 R /Border [0 0 0] /H /I /Rect [ 180.3888 507.5867 190.0262 516.4050 ] >> endobj 428 0 obj << /Type /Action >> endobj 429 0 obj << /Type /Annot /Subtype /Link /A 430 0 R /Border [0 0 0] /H /I /Rect [ 192.4355 507.5867 202.0728 516.4050 ] >> endobj 430 0 obj << /Type /Action >> endobj 431 0 obj << /Type /Annot /Subtype /Link /A 432 0 R /Border [0 0 0] /H /I /Rect [ 204.4822 507.5867 214.1195 516.4050 ] >> endobj 432 0 obj << /Type /Action >> endobj 433 0 obj << /Type /Annot /Subtype /Link /A 434 0 R /Border [0 0 0] /H /I /Rect [ 491.7150 495.6819 501.3523 504.5002 ] >> endobj 434 0 obj << /Type /Action >> endobj 435 0 obj << /Type /Annot /Subtype /Link /A 436 0 R /Border [0 0 0] /H /I /Rect [ 454.3530 400.4439 463.9903 409.2623 ] >> endobj 436 0 obj << /Type /Action >> endobj 437 0 obj << /Type /Annot /Subtype /Link /A 438 0 R /Border [0 0 0] /H /I /Rect [ 298.2847 345.3249 307.9221 354.1433 ] >> endobj 438 0 obj << /Type /Action >> endobj 439 0 obj << /Type /Annot /Subtype /Link /A 440 0 R /Border [0 0 0] /H /I /Rect [ 529.1160 333.4202 538.7533 342.2385 ] >> endobj 440 0 obj << /Type /Action >> endobj 441 0 obj << /Type /Annot /Subtype /Link /A 442 0 R /Border [0 0 0] /H /I /Rect [ 279.3112 713.0627 288.9486 721.8810 ] >> endobj 442 0 obj << /Type /Action >> endobj 443 0 obj << /Type /Annot /Subtype /Link /A 444 0 R /Border [0 0 0] /H /I /Rect [ 291.3579 713.0627 300.9953 721.8810 ] >> endobj 444 0 obj << /Type /Action >> endobj 445 0 obj << /Type /Annot /Subtype /Link /A 446 0 R /Border [0 0 0] /H /I /Rect [ 303.4046 713.0627 313.0419 721.8810 ] >> endobj 446 0 obj << /Type /Action >> endobj 447 0 obj << /Type /Annot /Subtype /Link /A 448 0 R /Border [0 0 0] /H /I /Rect [ 169.2922 677.3484 178.9296 686.1667 ] >> endobj 448 0 obj << /Type /Action >> endobj 449 0 obj << /Type /Annot /Subtype /Link /A 450 0 R /Border [0 0 0] /H /I /Rect [ 181.3389 677.3484 190.9763 686.1667 ] >> endobj 450 0 obj << /Type /Action >> endobj 451 0 obj << /Type /Annot /Subtype /Link /A 452 0 R /Border [0 0 0] /H /I /Rect [ 67.4340 665.4437 77.0713 674.2620 ] >> endobj 452 0 obj << /Type /Action >> endobj 453 0 obj << /Type /Annot /Subtype /Link /A 454 0 R /Border [0 0 0] /H /I /Rect [ 70.6710 598.4199 80.3083 607.2382 ] >> endobj 454 0 obj << /Type /Action >> endobj 455 0 obj << /Type /Annot /Subtype /Link /A 456 0 R /Border [0 0 0] /H /I /Rect [ 82.7177 598.4199 92.3550 607.2382 ] >> endobj 456 0 obj << /Type /Action >> endobj 457 0 obj << /Type /Annot /Subtype /Link /A 458 0 R /Border [0 0 0] /H /I /Rect [ 94.7643 598.4199 104.4017 607.2382 ] >> endobj 458 0 obj << /Type /Action >> endobj 459 0 obj << /Type /Annot /Subtype /Link /A 460 0 R /Border [0 0 0] /H /I /Rect [ 349.2188 574.6104 358.8561 583.4287 ] >> endobj 460 0 obj << /Type /Action >> endobj 461 0 obj << /Type /Annot /Subtype /Link /A 462 0 R /Border [0 0 0] /H /I /Rect [ 361.2654 574.6104 370.9028 583.4287 ] >> endobj 462 0 obj << /Type /Action >> endobj 463 0 obj << /Type /Annot /Subtype /Link /A 464 0 R /Border [0 0 0] /H /I /Rect [ 373.3121 574.6104 382.9494 583.4287 ] >> endobj 464 0 obj << /Type /Action >> endobj 465 0 obj << /Type /Annot /Subtype /Link /A 466 0 R /Border [0 0 0] /H /I /Rect [ 385.3588 574.6104 394.9961 583.4287 ] >> endobj 466 0 obj << /Type /Action >> endobj 467 0 obj << /Type /Annot /Subtype /Link /A 468 0 R /Border [0 0 0] /H /I /Rect [ 156.2955 507.5867 165.9328 516.4050 ] >> endobj 468 0 obj << /Type /Action >> endobj 469 0 obj << /Type /Annot /Subtype /Link /A 470 0 R /Border [0 0 0] /H /I /Rect [ 168.3422 507.5867 177.9795 516.4050 ] >> endobj 470 0 obj << /Type /Action >> endobj 471 0 obj << /Type /Annot /Subtype /Link /A 472 0 R /Border [0 0 0] /H /I /Rect [ 180.3888 507.5867 190.0262 516.4050 ] >> endobj 472 0 obj << /Type /Action >> endobj 473 0 obj << /Type /Annot /Subtype /Link /A 474 0 R /Border [0 0 0] /H /I /Rect [ 192.4355 507.5867 202.0728 516.4050 ] >> endobj 474 0 obj << /Type /Action >> endobj 475 0 obj << /Type /Annot /Subtype /Link /A 476 0 R /Border [0 0 0] /H /I /Rect [ 204.4822 507.5867 214.1195 516.4050 ] >> endobj 476 0 obj << /Type /Action >> endobj 477 0 obj << /Type /Annot /Subtype /Link /A 478 0 R /Border [0 0 0] /H /I /Rect [ 491.7150 495.6819 501.3523 504.5002 ] >> endobj 478 0 obj << /Type /Action >> endobj 479 0 obj << /Type /Annot /Subtype /Link /A 480 0 R /Border [0 0 0] /H /I /Rect [ 454.3530 400.4439 463.9903 409.2623 ] >> endobj 480 0 obj << /Type /Action >> endobj 481 0 obj << /Type /Annot /Subtype /Link /A 482 0 R /Border [0 0 0] /H /I /Rect [ 298.2847 345.3249 307.9221 354.1433 ] >> endobj 482 0 obj << /Type /Action >> endobj 483 0 obj << /Type /Annot /Subtype /Link /A 484 0 R /Border [0 0 0] /H /I /Rect [ 529.1160 333.4202 538.7533 342.2385 ] >> endobj 484 0 obj << /Type /Action >> endobj 485 0 obj << /Type /Annot /Subtype /Link /A 486 0 R /Border [0 0 0] /H /I /Rect [ 279.3112 713.0627 288.9486 721.8810 ] >> endobj 486 0 obj << /Type /Action >> endobj 487 0 obj << /Type /Annot /Subtype /Link /A 488 0 R /Border [0 0 0] /H /I /Rect [ 291.3579 713.0627 300.9953 721.8810 ] >> endobj 488 0 obj << /Type /Action >> endobj 489 0 obj << /Type /Annot /Subtype /Link /A 490 0 R /Border [0 0 0] /H /I /Rect [ 303.4046 713.0627 313.0419 721.8810 ] >> endobj 490 0 obj << /Type /Action >> endobj 491 0 obj << /Type /Annot /Subtype /Link /A 492 0 R /Border [0 0 0] /H /I /Rect [ 169.2922 677.3484 178.9296 686.1667 ] >> endobj 492 0 obj << /Type /Action >> endobj 493 0 obj << /Type /Annot /Subtype /Link /A 494 0 R /Border [0 0 0] /H /I /Rect [ 181.3389 677.3484 190.9763 686.1667 ] >> endobj 494 0 obj << /Type /Action >> endobj 495 0 obj << /Type /Annot /Subtype /Link /A 496 0 R /Border [0 0 0] /H /I /Rect [ 67.4340 665.4437 77.0713 674.2620 ] >> endobj 496 0 obj << /Type /Action >> endobj 497 0 obj << /Type /Annot /Subtype /Link /A 498 0 R /Border [0 0 0] /H /I /Rect [ 70.6710 598.4199 80.3083 607.2382 ] >> endobj 498 0 obj << /Type /Action >> endobj 499 0 obj << /Type /Annot /Subtype /Link /A 500 0 R /Border [0 0 0] /H /I /Rect [ 82.7177 598.4199 92.3550 607.2382 ] >> endobj 500 0 obj << /Type /Action >> endobj 501 0 obj << /Type /Annot /Subtype /Link /A 502 0 R /Border [0 0 0] /H /I /Rect [ 94.7643 598.4199 104.4017 607.2382 ] >> endobj 502 0 obj << /Type /Action >> endobj 503 0 obj << /Type /Annot /Subtype /Link /A 504 0 R /Border [0 0 0] /H /I /Rect [ 349.2188 574.6104 358.8561 583.4287 ] >> endobj 504 0 obj << /Type /Action >> endobj 505 0 obj << /Type /Annot /Subtype /Link /A 506 0 R /Border [0 0 0] /H /I /Rect [ 361.2654 574.6104 370.9028 583.4287 ] >> endobj 506 0 obj << /Type /Action >> endobj 507 0 obj << /Type /Annot /Subtype /Link /A 508 0 R /Border [0 0 0] /H /I /Rect [ 373.3121 574.6104 382.9494 583.4287 ] >> endobj 508 0 obj << /Type /Action >> endobj 509 0 obj << /Type /Annot /Subtype /Link /A 510 0 R /Border [0 0 0] /H /I /Rect [ 385.3588 574.6104 394.9961 583.4287 ] >> endobj 510 0 obj << /Type /Action >> endobj 511 0 obj << /Type /Annot /Subtype /Link /A 512 0 R /Border [0 0 0] /H /I /Rect [ 156.2955 507.5867 165.9328 516.4050 ] >> endobj 512 0 obj << /Type /Action >> endobj 513 0 obj << /Type /Annot /Subtype /Link /A 514 0 R /Border [0 0 0] /H /I /Rect [ 168.3422 507.5867 177.9795 516.4050 ] >> endobj 514 0 obj << /Type /Action >> endobj 515 0 obj << /Type /Annot /Subtype /Link /A 516 0 R /Border [0 0 0] /H /I /Rect [ 180.3888 507.5867 190.0262 516.4050 ] >> endobj 516 0 obj << /Type /Action >> endobj 517 0 obj << /Type /Annot /Subtype /Link /A 518 0 R /Border [0 0 0] /H /I /Rect [ 192.4355 507.5867 202.0728 516.4050 ] >> endobj 518 0 obj << /Type /Action >> endobj 519 0 obj << /Type /Annot /Subtype /Link /A 520 0 R /Border [0 0 0] /H /I /Rect [ 204.4822 507.5867 214.1195 516.4050 ] >> endobj 520 0 obj << /Type /Action >> endobj 521 0 obj << /Type /Annot /Subtype /Link /A 522 0 R /Border [0 0 0] /H /I /Rect [ 491.7150 495.6819 501.3523 504.5002 ] >> endobj 522 0 obj << /Type /Action >> endobj 523 0 obj << /Type /Annot /Subtype /Link /A 524 0 R /Border [0 0 0] /H /I /Rect [ 454.3530 400.4439 463.9903 409.2623 ] >> endobj 524 0 obj << /Type /Action >> endobj 525 0 obj << /Type /Annot /Subtype /Link /A 526 0 R /Border [0 0 0] /H /I /Rect [ 298.2847 345.3249 307.9221 354.1433 ] >> endobj 526 0 obj << /Type /Action >> endobj 527 0 obj << /Type /Annot /Subtype /Link /A 528 0 R /Border [0 0 0] /H /I /Rect [ 529.1160 333.4202 538.7533 342.2385 ] >> endobj 528 0 obj << /Type /Action >> endobj 529 0 obj << /Type /Page /Parent 3 0 R /Contents 530 0 R >> endobj 530 0 obj << /Length 18985 >> stream 0.271 0.267 0.267 rg q 15.000 32.202 577.500 744.798 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(perform worse on tests of the ability to recognize emotions, ToM and sarcasm in others. This is an interesting finding that may )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(be of importance for understanding the interpersonal problems often associated with HD. We speculate that one mechanism for )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(this finding may be that shared representations of self and other as well as insight and apathy may be closely connected and )] TJ ET BT 26.250 731.762 Td /F1 9.8 Tf [(may be mediated by overlapping neuroanatomical networks involving the prefrontal cortex and frontostriatal circuits. Therefore )] TJ ET BT 26.250 719.857 Td /F1 9.8 Tf [(we speculate that a flattening of affect or apathy and impaired insight has led to low self-report of psychological distress in our )] TJ ET BT 26.250 707.952 Td /F1 9.8 Tf [(cohort and that this was related to the weaker understanding of others \(i.e. poor social cognitive skills including emotion )] TJ ET BT 26.250 696.048 Td /F1 9.8 Tf [(recognition\).)] TJ ET BT 26.250 659.445 Td /F4 12.0 Tf [(Competing Interests Statement)] TJ ET BT 26.250 639.491 Td /F1 9.8 Tf [(The authors have declared that no competing interests exist)] TJ ET BT 26.250 602.888 Td /F4 12.0 Tf [(Data Availability Statement)] TJ ET BT 26.250 582.934 Td /F1 9.8 Tf [(All relevant data are within the manuscript.)] TJ ET BT 26.250 546.332 Td /F4 12.0 Tf [(Corresponding Author)] TJ ET BT 26.250 526.377 Td /F1 9.8 Tf [(Ida Unmack Larsen \(ida.unmack.larsen.01@regionh.dk\))] TJ ET BT 26.250 489.775 Td /F4 12.0 Tf [(References)] TJ ET BT 26.250 462.321 Td /F1 9.8 Tf [(1.)] TJ ET BT 38.132 462.321 Td /F1 9.8 Tf [(A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The )] TJ ET BT 26.250 450.416 Td /F1 9.8 Tf [(Huntington's Disease Collaborative Research Group. Cell. 1993 Mar 26;72\(6\):971-83. PubMed PMID:8458085.)] TJ ET BT 26.250 431.011 Td /F1 9.8 Tf [(2.)] TJ ET BT 38.132 431.011 Td /F1 9.8 Tf [(Larsen IU, Vinther-Jensen T, Gade A, Nielsen JE, Vogel A. Do I misconstrue? Sarcasm detection, emotion recognition, and )] TJ ET BT 26.250 419.106 Td /F1 9.8 Tf [(theory of mind in Huntington disease. Neuropsychology. 2016 Feb;30\(2\):181-9. PubMed PMID:26301773.)] TJ ET BT 26.250 399.702 Td /F1 9.8 Tf [(3.)] TJ ET BT 38.132 399.702 Td /F1 9.8 Tf [(Paulsen JS, Ready RE, Hamilton JM, Mega MS, Cummings JL. Neuropsychiatric aspects of Huntington's disease. J Neurol )] TJ ET BT 26.250 387.797 Td /F1 9.8 Tf [(Neurosurg Psychiatry. 2001 Sep;71\(3\):310-4. PubMed PMID:11511702.)] TJ ET BT 26.250 368.392 Td /F1 9.8 Tf [(4.)] TJ ET BT 38.132 368.392 Td /F1 9.8 Tf [(Unmack Larsen I, Vinther-Jensen T, Gade A, Nielsen JE, Vogel A. Assessing impairment of executive function and )] TJ ET BT 26.250 356.487 Td /F1 9.8 Tf [(psychomotor speed in premanifest and manifest Huntington's disease gene-expansion carriers. J Int Neuropsychol Soc. 2015 )] TJ ET BT 26.250 344.583 Td /F1 9.8 Tf [(Mar;21\(3\):193-202. PubMed PMID:25850430.)] TJ ET BT 26.250 325.178 Td /F1 9.8 Tf [(5.)] TJ ET BT 38.132 325.178 Td /F1 9.8 Tf [(Vinther-Jensen T, Larsen IU, Hjermind LE, Budtz-Jrgensen E, Nielsen TT, Nrremlle A, Nielsen JE, Vogel A. A clinical )] TJ ET BT 26.250 313.273 Td /F1 9.8 Tf [(classification acknowledging neuropsychiatric and cognitive impairment in Huntington's disease. Orphanet J Rare Dis. 2014 Jul )] TJ ET BT 26.250 301.368 Td /F1 9.8 Tf [(17;9:114. PubMed PMID:25026978.)] TJ ET BT 26.250 281.964 Td /F1 9.8 Tf [(6.)] TJ ET BT 38.132 281.964 Td /F1 9.8 Tf [(Alexander GE, DeLong MR, Strick PL. Parallel organization of functionally segregated circuits linking basal ganglia and )] TJ ET BT 26.250 270.059 Td /F1 9.8 Tf [(cortex. Annu Rev Neurosci. 1986;9:357-81. PubMed PMID:3085570.)] TJ ET BT 26.250 250.654 Td /F1 9.8 Tf [(7.)] TJ ET BT 38.132 250.654 Td /F1 9.8 Tf [(Tabrizi SJ, Scahill RI, Durr A, Roos RA, Leavitt BR, Jones R, Landwehrmeyer GB, Fox NC, Johnson H, Hicks SL, Kennard )] TJ ET BT 26.250 238.749 Td /F1 9.8 Tf [(C, Craufurd D, Frost C, Langbehn DR, Reilmann R, Stout JC. Biological and clinical changes in premanifest and early stage )] TJ ET BT 26.250 226.845 Td /F1 9.8 Tf [(Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis. Lancet Neurol. 2011 Jan;10\(1\):31-42. )] TJ ET BT 26.250 214.940 Td /F1 9.8 Tf [(PubMed PMID:21130037.)] TJ ET BT 26.250 195.535 Td /F1 9.8 Tf [(8.)] TJ ET BT 38.132 195.535 Td /F1 9.8 Tf [(Dumas EM, van den Bogaard SJ, Middelkoop HA, Roos RA. A review of cognition in Huntington's disease. Front Biosci )] TJ ET BT 26.250 183.630 Td /F1 9.8 Tf [(\(Schol Ed\). 2013 Jan 1;5:1-18. PubMed PMID:23277034.)] TJ ET BT 26.250 164.226 Td /F1 9.8 Tf [(9.)] TJ ET BT 38.132 164.226 Td /F1 9.8 Tf [(Eddy CM, Rickards HE. Theory of mind can be impaired prior to motor onset in Huntington's disease. Neuropsychology. )] TJ ET BT 26.250 152.321 Td /F1 9.8 Tf [(2015 Sep;29\(5\):792-8. PubMed PMID:25664466.)] TJ ET BT 26.250 132.916 Td /F1 9.8 Tf [(10.)] TJ ET BT 43.553 132.916 Td /F1 9.8 Tf [(Stout JC, Paulsen JS, Queller S, Solomon AC, Whitlock KB, Campbell JC, Carlozzi N, Duff K, Beglinger LJ, Langbehn DR, )] TJ ET BT 26.250 121.011 Td /F1 9.8 Tf [(Johnson SA, Biglan KM, Aylward EH. Neurocognitive signs in prodromal Huntington disease. Neuropsychology. 2011 )] TJ ET BT 26.250 109.107 Td /F1 9.8 Tf [(Jan;25\(1\):1-14. PubMed PMID:20919768.)] TJ ET BT 26.250 89.702 Td /F1 9.8 Tf [(11.)] TJ ET BT 43.553 89.702 Td /F1 9.8 Tf [(Craufurd D, Snowden JS. Neuropsychiatry and Neuropsychology. In: Bates G, Tabrizi SJ, Jones L, eds. Huntington's )] TJ ET BT 26.250 77.797 Td /F1 9.8 Tf [(Disease, 4 ed. New Yourk: Oxford University Press, 2014:36-65.)] TJ ET BT 26.250 58.392 Td /F1 9.8 Tf [(12.)] TJ ET BT 43.553 58.392 Td /F1 9.8 Tf [(Blumberg HP, Stern E, Ricketts S, Martinez D, de Asis J, White T, Epstein J, Isenberg N, McBride PA, Kemperman I, )] TJ ET BT 26.250 46.488 Td /F1 9.8 Tf [(Emmerich S, Dhawan V, Eidelberg D, Kocsis JH, Silbersweig DA. Rostral and orbital prefrontal cortex dysfunction in the manic )] TJ ET Q q 15.000 32.202 577.500 744.798 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(perform worse on tests of the ability to recognize emotions, ToM and sarcasm in others. This is an interesting finding that may )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(be of importance for understanding the interpersonal problems often associated with HD. We speculate that one mechanism for )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(this finding may be that shared representations of self and other as well as insight and apathy may be closely connected and )] TJ ET BT 26.250 731.762 Td /F1 9.8 Tf [(may be mediated by overlapping neuroanatomical networks involving the prefrontal cortex and frontostriatal circuits. Therefore )] TJ ET BT 26.250 719.857 Td /F1 9.8 Tf [(we speculate that a flattening of affect or apathy and impaired insight has led to low self-report of psychological distress in our )] TJ ET BT 26.250 707.952 Td /F1 9.8 Tf [(cohort and that this was related to the weaker understanding of others \(i.e. poor social cognitive skills including emotion )] TJ ET BT 26.250 696.048 Td /F1 9.8 Tf [(recognition\).)] TJ ET BT 26.250 659.445 Td /F4 12.0 Tf [(Competing Interests Statement)] TJ ET BT 26.250 639.491 Td /F1 9.8 Tf [(The authors have declared that no competing interests exist)] TJ ET BT 26.250 602.888 Td /F4 12.0 Tf [(Data Availability Statement)] TJ ET BT 26.250 582.934 Td /F1 9.8 Tf [(All relevant data are within the manuscript.)] TJ ET BT 26.250 546.332 Td /F4 12.0 Tf [(Corresponding Author)] TJ ET BT 26.250 526.377 Td /F1 9.8 Tf [(Ida Unmack Larsen \(ida.unmack.larsen.01@regionh.dk\))] TJ ET BT 26.250 489.775 Td /F4 12.0 Tf [(References)] TJ ET BT 26.250 462.321 Td /F1 9.8 Tf [(1.)] TJ ET BT 38.132 462.321 Td /F1 9.8 Tf [(A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The )] TJ ET BT 26.250 450.416 Td /F1 9.8 Tf [(Huntington's Disease Collaborative Research Group. Cell. 1993 Mar 26;72\(6\):971-83. PubMed PMID:8458085.)] TJ ET BT 26.250 431.011 Td /F1 9.8 Tf [(2.)] TJ ET BT 38.132 431.011 Td /F1 9.8 Tf [(Larsen IU, Vinther-Jensen T, Gade A, Nielsen JE, Vogel A. Do I misconstrue? Sarcasm detection, emotion recognition, and )] TJ ET BT 26.250 419.106 Td /F1 9.8 Tf [(theory of mind in Huntington disease. Neuropsychology. 2016 Feb;30\(2\):181-9. PubMed PMID:26301773.)] TJ ET BT 26.250 399.702 Td /F1 9.8 Tf [(3.)] TJ ET BT 38.132 399.702 Td /F1 9.8 Tf [(Paulsen JS, Ready RE, Hamilton JM, Mega MS, Cummings JL. Neuropsychiatric aspects of Huntington's disease. J Neurol )] TJ ET BT 26.250 387.797 Td /F1 9.8 Tf [(Neurosurg Psychiatry. 2001 Sep;71\(3\):310-4. PubMed PMID:11511702.)] TJ ET BT 26.250 368.392 Td /F1 9.8 Tf [(4.)] TJ ET BT 38.132 368.392 Td /F1 9.8 Tf [(Unmack Larsen I, Vinther-Jensen T, Gade A, Nielsen JE, Vogel A. Assessing impairment of executive function and )] TJ ET BT 26.250 356.487 Td /F1 9.8 Tf [(psychomotor speed in premanifest and manifest Huntington's disease gene-expansion carriers. J Int Neuropsychol Soc. 2015 )] TJ ET BT 26.250 344.583 Td /F1 9.8 Tf [(Mar;21\(3\):193-202. PubMed PMID:25850430.)] TJ ET BT 26.250 325.178 Td /F1 9.8 Tf [(5.)] TJ ET BT 38.132 325.178 Td /F1 9.8 Tf [(Vinther-Jensen T, Larsen IU, Hjermind LE, Budtz-Jrgensen E, Nielsen TT, Nrremlle A, Nielsen JE, Vogel A. A clinical )] TJ ET BT 26.250 313.273 Td /F1 9.8 Tf [(classification acknowledging neuropsychiatric and cognitive impairment in Huntington's disease. Orphanet J Rare Dis. 2014 Jul )] TJ ET BT 26.250 301.368 Td /F1 9.8 Tf [(17;9:114. PubMed PMID:25026978.)] TJ ET BT 26.250 281.964 Td /F1 9.8 Tf [(6.)] TJ ET BT 38.132 281.964 Td /F1 9.8 Tf [(Alexander GE, DeLong MR, Strick PL. Parallel organization of functionally segregated circuits linking basal ganglia and )] TJ ET BT 26.250 270.059 Td /F1 9.8 Tf [(cortex. Annu Rev Neurosci. 1986;9:357-81. PubMed PMID:3085570.)] TJ ET BT 26.250 250.654 Td /F1 9.8 Tf [(7.)] TJ ET BT 38.132 250.654 Td /F1 9.8 Tf [(Tabrizi SJ, Scahill RI, Durr A, Roos RA, Leavitt BR, Jones R, Landwehrmeyer GB, Fox NC, Johnson H, Hicks SL, Kennard )] TJ ET BT 26.250 238.749 Td /F1 9.8 Tf [(C, Craufurd D, Frost C, Langbehn DR, Reilmann R, Stout JC. Biological and clinical changes in premanifest and early stage )] TJ ET BT 26.250 226.845 Td /F1 9.8 Tf [(Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis. Lancet Neurol. 2011 Jan;10\(1\):31-42. )] TJ ET BT 26.250 214.940 Td /F1 9.8 Tf [(PubMed PMID:21130037.)] TJ ET BT 26.250 195.535 Td /F1 9.8 Tf [(8.)] TJ ET BT 38.132 195.535 Td /F1 9.8 Tf [(Dumas EM, van den Bogaard SJ, Middelkoop HA, Roos RA. A review of cognition in Huntington's disease. Front Biosci )] TJ ET BT 26.250 183.630 Td /F1 9.8 Tf [(\(Schol Ed\). 2013 Jan 1;5:1-18. PubMed PMID:23277034.)] TJ ET BT 26.250 164.226 Td /F1 9.8 Tf [(9.)] TJ ET BT 38.132 164.226 Td /F1 9.8 Tf [(Eddy CM, Rickards HE. Theory of mind can be impaired prior to motor onset in Huntington's disease. Neuropsychology. )] TJ ET BT 26.250 152.321 Td /F1 9.8 Tf [(2015 Sep;29\(5\):792-8. PubMed PMID:25664466.)] TJ ET BT 26.250 132.916 Td /F1 9.8 Tf [(10.)] TJ ET BT 43.553 132.916 Td /F1 9.8 Tf [(Stout JC, Paulsen JS, Queller S, Solomon AC, Whitlock KB, Campbell JC, Carlozzi N, Duff K, Beglinger LJ, Langbehn DR, )] TJ ET BT 26.250 121.011 Td /F1 9.8 Tf [(Johnson SA, Biglan KM, Aylward EH. Neurocognitive signs in prodromal Huntington disease. Neuropsychology. 2011 )] TJ ET BT 26.250 109.107 Td /F1 9.8 Tf [(Jan;25\(1\):1-14. PubMed PMID:20919768.)] TJ ET BT 26.250 89.702 Td /F1 9.8 Tf [(11.)] TJ ET BT 43.553 89.702 Td /F1 9.8 Tf [(Craufurd D, Snowden JS. Neuropsychiatry and Neuropsychology. In: Bates G, Tabrizi SJ, Jones L, eds. Huntington's )] TJ ET BT 26.250 77.797 Td /F1 9.8 Tf [(Disease, 4 ed. New Yourk: Oxford University Press, 2014:36-65.)] TJ ET BT 26.250 58.392 Td /F1 9.8 Tf [(12.)] TJ ET BT 43.553 58.392 Td /F1 9.8 Tf [(Blumberg HP, Stern E, Ricketts S, Martinez D, de Asis J, White T, Epstein J, Isenberg N, McBride PA, Kemperman I, )] TJ ET BT 26.250 46.488 Td /F1 9.8 Tf [(Emmerich S, Dhawan V, Eidelberg D, Kocsis JH, Silbersweig DA. Rostral and orbital prefrontal cortex dysfunction in the manic )] TJ ET Q q 15.000 32.202 577.500 744.798 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(perform worse on tests of the ability to recognize emotions, ToM and sarcasm in others. This is an interesting finding that may )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(be of importance for understanding the interpersonal problems often associated with HD. We speculate that one mechanism for )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(this finding may be that shared representations of self and other as well as insight and apathy may be closely connected and )] TJ ET BT 26.250 731.762 Td /F1 9.8 Tf [(may be mediated by overlapping neuroanatomical networks involving the prefrontal cortex and frontostriatal circuits. Therefore )] TJ ET BT 26.250 719.857 Td /F1 9.8 Tf [(we speculate that a flattening of affect or apathy and impaired insight has led to low self-report of psychological distress in our )] TJ ET BT 26.250 707.952 Td /F1 9.8 Tf [(cohort and that this was related to the weaker understanding of others \(i.e. poor social cognitive skills including emotion )] TJ ET BT 26.250 696.048 Td /F1 9.8 Tf [(recognition\).)] TJ ET BT 26.250 659.445 Td /F4 12.0 Tf [(Competing Interests Statement)] TJ ET BT 26.250 639.491 Td /F1 9.8 Tf [(The authors have declared that no competing interests exist)] TJ ET BT 26.250 602.888 Td /F4 12.0 Tf [(Data Availability Statement)] TJ ET BT 26.250 582.934 Td /F1 9.8 Tf [(All relevant data are within the manuscript.)] TJ ET BT 26.250 546.332 Td /F4 12.0 Tf [(Corresponding Author)] TJ ET BT 26.250 526.377 Td /F1 9.8 Tf [(Ida Unmack Larsen \(ida.unmack.larsen.01@regionh.dk\))] TJ ET BT 26.250 489.775 Td /F4 12.0 Tf [(References)] TJ ET BT 26.250 462.321 Td /F1 9.8 Tf [(1.)] TJ ET BT 38.132 462.321 Td /F1 9.8 Tf [(A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The )] TJ ET BT 26.250 450.416 Td /F1 9.8 Tf [(Huntington's Disease Collaborative Research Group. Cell. 1993 Mar 26;72\(6\):971-83. PubMed PMID:8458085.)] TJ ET BT 26.250 431.011 Td /F1 9.8 Tf [(2.)] TJ ET BT 38.132 431.011 Td /F1 9.8 Tf [(Larsen IU, Vinther-Jensen T, Gade A, Nielsen JE, Vogel A. Do I misconstrue? Sarcasm detection, emotion recognition, and )] TJ ET BT 26.250 419.106 Td /F1 9.8 Tf [(theory of mind in Huntington disease. Neuropsychology. 2016 Feb;30\(2\):181-9. PubMed PMID:26301773.)] TJ ET BT 26.250 399.702 Td /F1 9.8 Tf [(3.)] TJ ET BT 38.132 399.702 Td /F1 9.8 Tf [(Paulsen JS, Ready RE, Hamilton JM, Mega MS, Cummings JL. Neuropsychiatric aspects of Huntington's disease. J Neurol )] TJ ET BT 26.250 387.797 Td /F1 9.8 Tf [(Neurosurg Psychiatry. 2001 Sep;71\(3\):310-4. PubMed PMID:11511702.)] TJ ET BT 26.250 368.392 Td /F1 9.8 Tf [(4.)] TJ ET BT 38.132 368.392 Td /F1 9.8 Tf [(Unmack Larsen I, Vinther-Jensen T, Gade A, Nielsen JE, Vogel A. Assessing impairment of executive function and )] TJ ET BT 26.250 356.487 Td /F1 9.8 Tf [(psychomotor speed in premanifest and manifest Huntington's disease gene-expansion carriers. J Int Neuropsychol Soc. 2015 )] TJ ET BT 26.250 344.583 Td /F1 9.8 Tf [(Mar;21\(3\):193-202. PubMed PMID:25850430.)] TJ ET BT 26.250 325.178 Td /F1 9.8 Tf [(5.)] TJ ET BT 38.132 325.178 Td /F1 9.8 Tf [(Vinther-Jensen T, Larsen IU, Hjermind LE, Budtz-Jrgensen E, Nielsen TT, Nrremlle A, Nielsen JE, Vogel A. A clinical )] TJ ET BT 26.250 313.273 Td /F1 9.8 Tf [(classification acknowledging neuropsychiatric and cognitive impairment in Huntington's disease. Orphanet J Rare Dis. 2014 Jul )] TJ ET BT 26.250 301.368 Td /F1 9.8 Tf [(17;9:114. PubMed PMID:25026978.)] TJ ET BT 26.250 281.964 Td /F1 9.8 Tf [(6.)] TJ ET BT 38.132 281.964 Td /F1 9.8 Tf [(Alexander GE, DeLong MR, Strick PL. Parallel organization of functionally segregated circuits linking basal ganglia and )] TJ ET BT 26.250 270.059 Td /F1 9.8 Tf [(cortex. Annu Rev Neurosci. 1986;9:357-81. PubMed PMID:3085570.)] TJ ET BT 26.250 250.654 Td /F1 9.8 Tf [(7.)] TJ ET BT 38.132 250.654 Td /F1 9.8 Tf [(Tabrizi SJ, Scahill RI, Durr A, Roos RA, Leavitt BR, Jones R, Landwehrmeyer GB, Fox NC, Johnson H, Hicks SL, Kennard )] TJ ET BT 26.250 238.749 Td /F1 9.8 Tf [(C, Craufurd D, Frost C, Langbehn DR, Reilmann R, Stout JC. Biological and clinical changes in premanifest and early stage )] TJ ET BT 26.250 226.845 Td /F1 9.8 Tf [(Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis. Lancet Neurol. 2011 Jan;10\(1\):31-42. )] TJ ET BT 26.250 214.940 Td /F1 9.8 Tf [(PubMed PMID:21130037.)] TJ ET BT 26.250 195.535 Td /F1 9.8 Tf [(8.)] TJ ET BT 38.132 195.535 Td /F1 9.8 Tf [(Dumas EM, van den Bogaard SJ, Middelkoop HA, Roos RA. A review of cognition in Huntington's disease. Front Biosci )] TJ ET BT 26.250 183.630 Td /F1 9.8 Tf [(\(Schol Ed\). 2013 Jan 1;5:1-18. PubMed PMID:23277034.)] TJ ET BT 26.250 164.226 Td /F1 9.8 Tf [(9.)] TJ ET BT 38.132 164.226 Td /F1 9.8 Tf [(Eddy CM, Rickards HE. Theory of mind can be impaired prior to motor onset in Huntington's disease. Neuropsychology. )] TJ ET BT 26.250 152.321 Td /F1 9.8 Tf [(2015 Sep;29\(5\):792-8. PubMed PMID:25664466.)] TJ ET BT 26.250 132.916 Td /F1 9.8 Tf [(10.)] TJ ET BT 43.553 132.916 Td /F1 9.8 Tf [(Stout JC, Paulsen JS, Queller S, Solomon AC, Whitlock KB, Campbell JC, Carlozzi N, Duff K, Beglinger LJ, Langbehn DR, )] TJ ET BT 26.250 121.011 Td /F1 9.8 Tf [(Johnson SA, Biglan KM, Aylward EH. Neurocognitive signs in prodromal Huntington disease. Neuropsychology. 2011 )] TJ ET BT 26.250 109.107 Td /F1 9.8 Tf [(Jan;25\(1\):1-14. PubMed PMID:20919768.)] TJ ET BT 26.250 89.702 Td /F1 9.8 Tf [(11.)] TJ ET BT 43.553 89.702 Td /F1 9.8 Tf [(Craufurd D, Snowden JS. Neuropsychiatry and Neuropsychology. In: Bates G, Tabrizi SJ, Jones L, eds. Huntington's )] TJ ET BT 26.250 77.797 Td /F1 9.8 Tf [(Disease, 4 ed. New Yourk: Oxford University Press, 2014:36-65.)] TJ ET BT 26.250 58.392 Td /F1 9.8 Tf [(12.)] TJ ET BT 43.553 58.392 Td /F1 9.8 Tf [(Blumberg HP, Stern E, Ricketts S, Martinez D, de Asis J, White T, Epstein J, Isenberg N, McBride PA, Kemperman I, )] TJ ET BT 26.250 46.488 Td /F1 9.8 Tf [(Emmerich S, Dhawan V, Eidelberg D, Kocsis JH, Silbersweig DA. Rostral and orbital prefrontal cortex dysfunction in the manic )] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(8)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Huntington Disease)] TJ ET Q endstream endobj 531 0 obj << /Type /Page /Parent 3 0 R /Contents 532 0 R >> endobj 532 0 obj << /Length 21508 >> stream 0.271 0.267 0.267 rg q 15.000 41.882 577.500 735.118 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(state of bipolar disorder. Am J Psychiatry. 1999 Dec;156\(12\):1986-8. PubMed PMID:10588416.)] TJ ET BT 26.250 748.071 Td /F1 9.8 Tf [(13.)] TJ ET BT 43.553 748.071 Td /F1 9.8 Tf [(Eslinger PJ, Moore P, Antani S, Anderson C, Grossman M. Apathy in frontotemporal dementia: behavioral and )] TJ ET BT 26.250 736.167 Td /F1 9.8 Tf [(neuroimaging correlates. Behavioural neurology 2012;25:127-136.)] TJ ET BT 26.250 716.762 Td /F1 9.8 Tf [(14.)] TJ ET BT 43.553 716.762 Td /F1 9.8 Tf [(Hoertnagl CM, Hofer A. Social cognition in serious mental illness. Curr Opin Psychiatry 2014 May;27:197-202.)] TJ ET BT 26.250 697.357 Td /F1 9.8 Tf [(15.)] TJ ET BT 43.553 697.357 Td /F1 9.8 Tf [(Hoff AL, Kremen WS. Is there a cognitive phenotype for schizophrenia: the nature and course of the disturbance in )] TJ ET BT 26.250 685.452 Td /F1 9.8 Tf [(cognition? Current opinion in psychiatry 2002;15:43-48.)] TJ ET BT 26.250 666.048 Td /F1 9.8 Tf [(16.)] TJ ET BT 43.553 666.048 Td /F1 9.8 Tf [(Lam BY, Raine A, Lee TM. The relationship between neurocognition and symptomatology in people with schizophrenia: )] TJ ET BT 26.250 654.143 Td /F1 9.8 Tf [(social cognition as the mediator. BMC psychiatry 2014;14:138.)] TJ ET BT 26.250 634.738 Td /F1 9.8 Tf [(17.)] TJ ET BT 43.553 634.738 Td /F1 9.8 Tf [(Pagonabarraga J, Kulisevsky J, Strafella AP, Krack P. Apathy in Parkinson's disease: clinical features, neural substrates, )] TJ ET BT 26.250 622.833 Td /F1 9.8 Tf [(diagnosis, and treatment. Lancet Neurol 2015;14:518-531.)] TJ ET BT 26.250 603.429 Td /F1 9.8 Tf [(18.)] TJ ET BT 43.553 603.429 Td /F1 9.8 Tf [(Porter RJ, Bourke C, Gallagher P. Neuropsychological impairment in major depression: its nature, origin and clinical )] TJ ET BT 26.250 591.524 Td /F1 9.8 Tf [(significance. Aust N Z J Psychiatry 2007 Feb;41:115-128.)] TJ ET BT 26.250 572.119 Td /F1 9.8 Tf [(19.)] TJ ET BT 43.553 572.119 Td /F1 9.8 Tf [(Unified Huntington's Disease Rating Scale: reliability and consistency. Huntington Study Group. Mov Disord 1996 )] TJ ET BT 26.250 560.214 Td /F1 9.8 Tf [(Mar;11:136-142.)] TJ ET BT 26.250 540.810 Td /F1 9.8 Tf [(20.)] TJ ET BT 43.553 540.810 Td /F1 9.8 Tf [(Nasreddine ZS, Phillips NA, Bedirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild )] TJ ET BT 26.250 528.905 Td /F1 9.8 Tf [(cognitive impairment. J Am Geriatr Soc 2005 Apr;53:695-699.)] TJ ET BT 26.250 509.500 Td /F1 9.8 Tf [(21.)] TJ ET BT 43.553 509.500 Td /F1 9.8 Tf [(Vinther-Jensen T, Nielsen TT, Budtz-Jrgensen E, et al. Psychiatric and cognitive symptoms in Huntington's disease are )] TJ ET BT 26.250 497.595 Td /F1 9.8 Tf [(modified by polymorphisms in catecholamine regulating enzyme genes. Clinical genetics 2015;89:320-327.)] TJ ET BT 26.250 478.191 Td /F1 9.8 Tf [(22.)] TJ ET BT 43.553 478.191 Td /F1 9.8 Tf [(Mortensen EL, Gade A. On the relation between demographic variables and neuropsychological test performance. )] TJ ET BT 26.250 466.286 Td /F1 9.8 Tf [(Scandinavian Journal of Psychology 1993;34:305-317.)] TJ ET BT 26.250 446.881 Td /F1 9.8 Tf [(23.)] TJ ET BT 43.553 446.881 Td /F1 9.8 Tf [(Sprengelmeyer R, Young AW, Calder AJ, et al. Loss of disgust. Perception of faces and emotions in Huntington's disease. )] TJ ET BT 26.250 434.976 Td /F1 9.8 Tf [(Brain 1996 Oct;119 \( Pt 5\):1647-1665.)] TJ ET BT 26.250 415.572 Td /F1 9.8 Tf [(24.)] TJ ET BT 43.553 415.572 Td /F1 9.8 Tf [(McDonald S, Flanagan S, Rollins J, Kinch J. TASIT: A new clinical tool for assessing social perception after traumatic brain )] TJ ET BT 26.250 403.667 Td /F1 9.8 Tf [(injury. J Head Trauma Rehabil 2003 May;18:219-238.)] TJ ET BT 26.250 384.262 Td /F1 9.8 Tf [(25.)] TJ ET BT 43.553 384.262 Td /F1 9.8 Tf [(Baron-Cohen S, Wheelwright S, Hill J, Raste Y, Plumb I. The "Reading the Mind in the Eyes" Test revised version: a study )] TJ ET BT 26.250 372.357 Td /F1 9.8 Tf [(with normal adults, and adults with Asperger syndrome or high-functioning autism. J Child Psychol Psychiatry 2001 Feb;42:241-)] TJ ET BT 26.250 360.453 Td /F1 9.8 Tf [(251.)] TJ ET BT 26.250 341.048 Td /F1 9.8 Tf [(26.)] TJ ET BT 43.553 341.048 Td /F1 9.8 Tf [(Lezak MD, Howieson DB, Loring DW. Executive Functions and Motor Performance. Neuropsychological assessment, fourth )] TJ ET BT 26.250 329.143 Td /F1 9.8 Tf [(ed. New York: Oxford University Press, 2004:611-646.)] TJ ET BT 26.250 309.738 Td /F1 9.8 Tf [(27.)] TJ ET BT 43.553 309.738 Td /F1 9.8 Tf [(Reitan RM. The relation of the trail making test to organic brain damage. J Consult Psychol 1955;19:393-394.)] TJ ET BT 26.250 290.334 Td /F1 9.8 Tf [(28.)] TJ ET BT 43.553 290.334 Td /F1 9.8 Tf [(Stroop JR. Studies of interference in serial verbal reactions. Journal of Experimental Psychology 1935;18:643-662.)] TJ ET BT 26.250 270.929 Td /F1 9.8 Tf [(29.)] TJ ET BT 43.553 270.929 Td /F1 9.8 Tf [(Derogatis LR. SCL-90-R Symptom Checklist 90-R. Copenhagen: Psykologisk Forlag A/S, 1977.)] TJ ET BT 26.250 251.524 Td /F1 9.8 Tf [(30.)] TJ ET BT 43.553 251.524 Td /F1 9.8 Tf [(Chatterjee A, Anderson KE, Moskowitz CB, Hauser WA, Marder KS. A comparison of self-report and caregiver assessment )] TJ ET BT 26.250 239.619 Td /F1 9.8 Tf [(of depression, apathy, and irritability in Huntington's disease. The Journal of neuropsychiatry and clinical neurosciences )] TJ ET BT 26.250 227.715 Td /F1 9.8 Tf [(2014;17:378-383.)] TJ ET BT 26.250 208.310 Td /F1 9.8 Tf [(31.)] TJ ET BT 43.553 208.310 Td /F1 9.8 Tf [(Sitek EJ, Thompson JC, Craufurd D, Snowden JS. Unawareness of Deficits in Huntington's Disease. Journal of )] TJ ET BT 26.250 196.405 Td /F1 9.8 Tf [(Huntington's disease 2014;3:125-135.)] TJ ET BT 26.250 177.000 Td /F1 9.8 Tf [(32.)] TJ ET BT 43.553 177.000 Td /F1 9.8 Tf [(O'Keeffe FM, Murray B, Coen RF, et al. Loss of insight in frontotemporal dementia, corticobasal degeneration and )] TJ ET BT 26.250 165.096 Td /F1 9.8 Tf [(progressive supranuclear palsy. Brain 2007;130:753-764.)] TJ ET BT 26.250 145.691 Td /F1 9.8 Tf [(33.)] TJ ET BT 43.553 145.691 Td /F1 9.8 Tf [(Decety J, Sommerville JA. Shared representations between self and other: a social cognitive neuroscience view. Trends in )] TJ ET BT 26.250 133.786 Td /F1 9.8 Tf [(cognitive sciences 2003;7:527-533.)] TJ ET BT 26.250 114.381 Td /F1 9.8 Tf [(34.)] TJ ET BT 43.553 114.381 Td /F1 9.8 Tf [(Gallagher S, Meltzoff AN. The earliest sense of self and others: Merleau-Ponty and recent developmental studies. )] TJ ET BT 26.250 102.477 Td /F1 9.8 Tf [(Philosophical psychology 1996;9:211-233.)] TJ ET BT 26.250 83.072 Td /F1 9.8 Tf [(35.)] TJ ET BT 43.553 83.072 Td /F1 9.8 Tf [(Abu-Akel A. A neurobiological mapping of theory of mind. Brain research reviews 2003;43:29-40.)] TJ ET BT 26.250 63.667 Td /F1 9.8 Tf [(36.)] TJ ET BT 43.553 63.667 Td /F1 9.8 Tf [(Abu-Akel A, Shamay-Tsoory S. Neuroanatomical and neurochemical bases of theory of mind. Neuropsychologia )] TJ ET BT 26.250 51.762 Td /F1 9.8 Tf [(2011;49:2971-2984.)] TJ ET Q q 15.000 41.882 577.500 735.118 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(state of bipolar disorder. Am J Psychiatry. 1999 Dec;156\(12\):1986-8. PubMed PMID:10588416.)] TJ ET BT 26.250 748.071 Td /F1 9.8 Tf [(13.)] TJ ET BT 43.553 748.071 Td /F1 9.8 Tf [(Eslinger PJ, Moore P, Antani S, Anderson C, Grossman M. Apathy in frontotemporal dementia: behavioral and )] TJ ET BT 26.250 736.167 Td /F1 9.8 Tf [(neuroimaging correlates. Behavioural neurology 2012;25:127-136.)] TJ ET BT 26.250 716.762 Td /F1 9.8 Tf [(14.)] TJ ET BT 43.553 716.762 Td /F1 9.8 Tf [(Hoertnagl CM, Hofer A. Social cognition in serious mental illness. Curr Opin Psychiatry 2014 May;27:197-202.)] TJ ET BT 26.250 697.357 Td /F1 9.8 Tf [(15.)] TJ ET BT 43.553 697.357 Td /F1 9.8 Tf [(Hoff AL, Kremen WS. Is there a cognitive phenotype for schizophrenia: the nature and course of the disturbance in )] TJ ET BT 26.250 685.452 Td /F1 9.8 Tf [(cognition? Current opinion in psychiatry 2002;15:43-48.)] TJ ET BT 26.250 666.048 Td /F1 9.8 Tf [(16.)] TJ ET BT 43.553 666.048 Td /F1 9.8 Tf [(Lam BY, Raine A, Lee TM. The relationship between neurocognition and symptomatology in people with schizophrenia: )] TJ ET BT 26.250 654.143 Td /F1 9.8 Tf [(social cognition as the mediator. BMC psychiatry 2014;14:138.)] TJ ET BT 26.250 634.738 Td /F1 9.8 Tf [(17.)] TJ ET BT 43.553 634.738 Td /F1 9.8 Tf [(Pagonabarraga J, Kulisevsky J, Strafella AP, Krack P. Apathy in Parkinson's disease: clinical features, neural substrates, )] TJ ET BT 26.250 622.833 Td /F1 9.8 Tf [(diagnosis, and treatment. Lancet Neurol 2015;14:518-531.)] TJ ET BT 26.250 603.429 Td /F1 9.8 Tf [(18.)] TJ ET BT 43.553 603.429 Td /F1 9.8 Tf [(Porter RJ, Bourke C, Gallagher P. Neuropsychological impairment in major depression: its nature, origin and clinical )] TJ ET BT 26.250 591.524 Td /F1 9.8 Tf [(significance. Aust N Z J Psychiatry 2007 Feb;41:115-128.)] TJ ET BT 26.250 572.119 Td /F1 9.8 Tf [(19.)] TJ ET BT 43.553 572.119 Td /F1 9.8 Tf [(Unified Huntington's Disease Rating Scale: reliability and consistency. Huntington Study Group. Mov Disord 1996 )] TJ ET BT 26.250 560.214 Td /F1 9.8 Tf [(Mar;11:136-142.)] TJ ET BT 26.250 540.810 Td /F1 9.8 Tf [(20.)] TJ ET BT 43.553 540.810 Td /F1 9.8 Tf [(Nasreddine ZS, Phillips NA, Bedirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild )] TJ ET BT 26.250 528.905 Td /F1 9.8 Tf [(cognitive impairment. J Am Geriatr Soc 2005 Apr;53:695-699.)] TJ ET BT 26.250 509.500 Td /F1 9.8 Tf [(21.)] TJ ET BT 43.553 509.500 Td /F1 9.8 Tf [(Vinther-Jensen T, Nielsen TT, Budtz-Jrgensen E, et al. Psychiatric and cognitive symptoms in Huntington's disease are )] TJ ET BT 26.250 497.595 Td /F1 9.8 Tf [(modified by polymorphisms in catecholamine regulating enzyme genes. Clinical genetics 2015;89:320-327.)] TJ ET BT 26.250 478.191 Td /F1 9.8 Tf [(22.)] TJ ET BT 43.553 478.191 Td /F1 9.8 Tf [(Mortensen EL, Gade A. On the relation between demographic variables and neuropsychological test performance. )] TJ ET BT 26.250 466.286 Td /F1 9.8 Tf [(Scandinavian Journal of Psychology 1993;34:305-317.)] TJ ET BT 26.250 446.881 Td /F1 9.8 Tf [(23.)] TJ ET BT 43.553 446.881 Td /F1 9.8 Tf [(Sprengelmeyer R, Young AW, Calder AJ, et al. Loss of disgust. Perception of faces and emotions in Huntington's disease. )] TJ ET BT 26.250 434.976 Td /F1 9.8 Tf [(Brain 1996 Oct;119 \( Pt 5\):1647-1665.)] TJ ET BT 26.250 415.572 Td /F1 9.8 Tf [(24.)] TJ ET BT 43.553 415.572 Td /F1 9.8 Tf [(McDonald S, Flanagan S, Rollins J, Kinch J. TASIT: A new clinical tool for assessing social perception after traumatic brain )] TJ ET BT 26.250 403.667 Td /F1 9.8 Tf [(injury. J Head Trauma Rehabil 2003 May;18:219-238.)] TJ ET BT 26.250 384.262 Td /F1 9.8 Tf [(25.)] TJ ET BT 43.553 384.262 Td /F1 9.8 Tf [(Baron-Cohen S, Wheelwright S, Hill J, Raste Y, Plumb I. The "Reading the Mind in the Eyes" Test revised version: a study )] TJ ET BT 26.250 372.357 Td /F1 9.8 Tf [(with normal adults, and adults with Asperger syndrome or high-functioning autism. J Child Psychol Psychiatry 2001 Feb;42:241-)] TJ ET BT 26.250 360.453 Td /F1 9.8 Tf [(251.)] TJ ET BT 26.250 341.048 Td /F1 9.8 Tf [(26.)] TJ ET BT 43.553 341.048 Td /F1 9.8 Tf [(Lezak MD, Howieson DB, Loring DW. Executive Functions and Motor Performance. Neuropsychological assessment, fourth )] TJ ET BT 26.250 329.143 Td /F1 9.8 Tf [(ed. New York: Oxford University Press, 2004:611-646.)] TJ ET BT 26.250 309.738 Td /F1 9.8 Tf [(27.)] TJ ET BT 43.553 309.738 Td /F1 9.8 Tf [(Reitan RM. The relation of the trail making test to organic brain damage. J Consult Psychol 1955;19:393-394.)] TJ ET BT 26.250 290.334 Td /F1 9.8 Tf [(28.)] TJ ET BT 43.553 290.334 Td /F1 9.8 Tf [(Stroop JR. Studies of interference in serial verbal reactions. Journal of Experimental Psychology 1935;18:643-662.)] TJ ET BT 26.250 270.929 Td /F1 9.8 Tf [(29.)] TJ ET BT 43.553 270.929 Td /F1 9.8 Tf [(Derogatis LR. SCL-90-R Symptom Checklist 90-R. Copenhagen: Psykologisk Forlag A/S, 1977.)] TJ ET BT 26.250 251.524 Td /F1 9.8 Tf [(30.)] TJ ET BT 43.553 251.524 Td /F1 9.8 Tf [(Chatterjee A, Anderson KE, Moskowitz CB, Hauser WA, Marder KS. A comparison of self-report and caregiver assessment )] TJ ET BT 26.250 239.619 Td /F1 9.8 Tf [(of depression, apathy, and irritability in Huntington's disease. The Journal of neuropsychiatry and clinical neurosciences )] TJ ET BT 26.250 227.715 Td /F1 9.8 Tf [(2014;17:378-383.)] TJ ET BT 26.250 208.310 Td /F1 9.8 Tf [(31.)] TJ ET BT 43.553 208.310 Td /F1 9.8 Tf [(Sitek EJ, Thompson JC, Craufurd D, Snowden JS. Unawareness of Deficits in Huntington's Disease. Journal of )] TJ ET BT 26.250 196.405 Td /F1 9.8 Tf [(Huntington's disease 2014;3:125-135.)] TJ ET BT 26.250 177.000 Td /F1 9.8 Tf [(32.)] TJ ET BT 43.553 177.000 Td /F1 9.8 Tf [(O'Keeffe FM, Murray B, Coen RF, et al. Loss of insight in frontotemporal dementia, corticobasal degeneration and )] TJ ET BT 26.250 165.096 Td /F1 9.8 Tf [(progressive supranuclear palsy. Brain 2007;130:753-764.)] TJ ET BT 26.250 145.691 Td /F1 9.8 Tf [(33.)] TJ ET BT 43.553 145.691 Td /F1 9.8 Tf [(Decety J, Sommerville JA. Shared representations between self and other: a social cognitive neuroscience view. Trends in )] TJ ET BT 26.250 133.786 Td /F1 9.8 Tf [(cognitive sciences 2003;7:527-533.)] TJ ET BT 26.250 114.381 Td /F1 9.8 Tf [(34.)] TJ ET BT 43.553 114.381 Td /F1 9.8 Tf [(Gallagher S, Meltzoff AN. The earliest sense of self and others: Merleau-Ponty and recent developmental studies. )] TJ ET BT 26.250 102.477 Td /F1 9.8 Tf [(Philosophical psychology 1996;9:211-233.)] TJ ET BT 26.250 83.072 Td /F1 9.8 Tf [(35.)] TJ ET BT 43.553 83.072 Td /F1 9.8 Tf [(Abu-Akel A. A neurobiological mapping of theory of mind. Brain research reviews 2003;43:29-40.)] TJ ET BT 26.250 63.667 Td /F1 9.8 Tf [(36.)] TJ ET BT 43.553 63.667 Td /F1 9.8 Tf [(Abu-Akel A, Shamay-Tsoory S. Neuroanatomical and neurochemical bases of theory of mind. Neuropsychologia )] TJ ET BT 26.250 51.762 Td /F1 9.8 Tf [(2011;49:2971-2984.)] TJ ET Q q 15.000 41.882 577.500 735.118 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(state of bipolar disorder. Am J Psychiatry. 1999 Dec;156\(12\):1986-8. PubMed PMID:10588416.)] TJ ET BT 26.250 748.071 Td /F1 9.8 Tf [(13.)] TJ ET BT 43.553 748.071 Td /F1 9.8 Tf [(Eslinger PJ, Moore P, Antani S, Anderson C, Grossman M. Apathy in frontotemporal dementia: behavioral and )] TJ ET BT 26.250 736.167 Td /F1 9.8 Tf [(neuroimaging correlates. Behavioural neurology 2012;25:127-136.)] TJ ET BT 26.250 716.762 Td /F1 9.8 Tf [(14.)] TJ ET BT 43.553 716.762 Td /F1 9.8 Tf [(Hoertnagl CM, Hofer A. Social cognition in serious mental illness. Curr Opin Psychiatry 2014 May;27:197-202.)] TJ ET BT 26.250 697.357 Td /F1 9.8 Tf [(15.)] TJ ET BT 43.553 697.357 Td /F1 9.8 Tf [(Hoff AL, Kremen WS. Is there a cognitive phenotype for schizophrenia: the nature and course of the disturbance in )] TJ ET BT 26.250 685.452 Td /F1 9.8 Tf [(cognition? Current opinion in psychiatry 2002;15:43-48.)] TJ ET BT 26.250 666.048 Td /F1 9.8 Tf [(16.)] TJ ET BT 43.553 666.048 Td /F1 9.8 Tf [(Lam BY, Raine A, Lee TM. The relationship between neurocognition and symptomatology in people with schizophrenia: )] TJ ET BT 26.250 654.143 Td /F1 9.8 Tf [(social cognition as the mediator. BMC psychiatry 2014;14:138.)] TJ ET BT 26.250 634.738 Td /F1 9.8 Tf [(17.)] TJ ET BT 43.553 634.738 Td /F1 9.8 Tf [(Pagonabarraga J, Kulisevsky J, Strafella AP, Krack P. Apathy in Parkinson's disease: clinical features, neural substrates, )] TJ ET BT 26.250 622.833 Td /F1 9.8 Tf [(diagnosis, and treatment. Lancet Neurol 2015;14:518-531.)] TJ ET BT 26.250 603.429 Td /F1 9.8 Tf [(18.)] TJ ET BT 43.553 603.429 Td /F1 9.8 Tf [(Porter RJ, Bourke C, Gallagher P. Neuropsychological impairment in major depression: its nature, origin and clinical )] TJ ET BT 26.250 591.524 Td /F1 9.8 Tf [(significance. Aust N Z J Psychiatry 2007 Feb;41:115-128.)] TJ ET BT 26.250 572.119 Td /F1 9.8 Tf [(19.)] TJ ET BT 43.553 572.119 Td /F1 9.8 Tf [(Unified Huntington's Disease Rating Scale: reliability and consistency. Huntington Study Group. Mov Disord 1996 )] TJ ET BT 26.250 560.214 Td /F1 9.8 Tf [(Mar;11:136-142.)] TJ ET BT 26.250 540.810 Td /F1 9.8 Tf [(20.)] TJ ET BT 43.553 540.810 Td /F1 9.8 Tf [(Nasreddine ZS, Phillips NA, Bedirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild )] TJ ET BT 26.250 528.905 Td /F1 9.8 Tf [(cognitive impairment. J Am Geriatr Soc 2005 Apr;53:695-699.)] TJ ET BT 26.250 509.500 Td /F1 9.8 Tf [(21.)] TJ ET BT 43.553 509.500 Td /F1 9.8 Tf [(Vinther-Jensen T, Nielsen TT, Budtz-Jrgensen E, et al. Psychiatric and cognitive symptoms in Huntington's disease are )] TJ ET BT 26.250 497.595 Td /F1 9.8 Tf [(modified by polymorphisms in catecholamine regulating enzyme genes. Clinical genetics 2015;89:320-327.)] TJ ET BT 26.250 478.191 Td /F1 9.8 Tf [(22.)] TJ ET BT 43.553 478.191 Td /F1 9.8 Tf [(Mortensen EL, Gade A. On the relation between demographic variables and neuropsychological test performance. )] TJ ET BT 26.250 466.286 Td /F1 9.8 Tf [(Scandinavian Journal of Psychology 1993;34:305-317.)] TJ ET BT 26.250 446.881 Td /F1 9.8 Tf [(23.)] TJ ET BT 43.553 446.881 Td /F1 9.8 Tf [(Sprengelmeyer R, Young AW, Calder AJ, et al. Loss of disgust. Perception of faces and emotions in Huntington's disease. )] TJ ET BT 26.250 434.976 Td /F1 9.8 Tf [(Brain 1996 Oct;119 \( Pt 5\):1647-1665.)] TJ ET BT 26.250 415.572 Td /F1 9.8 Tf [(24.)] TJ ET BT 43.553 415.572 Td /F1 9.8 Tf [(McDonald S, Flanagan S, Rollins J, Kinch J. TASIT: A new clinical tool for assessing social perception after traumatic brain )] TJ ET BT 26.250 403.667 Td /F1 9.8 Tf [(injury. J Head Trauma Rehabil 2003 May;18:219-238.)] TJ ET BT 26.250 384.262 Td /F1 9.8 Tf [(25.)] TJ ET BT 43.553 384.262 Td /F1 9.8 Tf [(Baron-Cohen S, Wheelwright S, Hill J, Raste Y, Plumb I. The "Reading the Mind in the Eyes" Test revised version: a study )] TJ ET BT 26.250 372.357 Td /F1 9.8 Tf [(with normal adults, and adults with Asperger syndrome or high-functioning autism. J Child Psychol Psychiatry 2001 Feb;42:241-)] TJ ET BT 26.250 360.453 Td /F1 9.8 Tf [(251.)] TJ ET BT 26.250 341.048 Td /F1 9.8 Tf [(26.)] TJ ET BT 43.553 341.048 Td /F1 9.8 Tf [(Lezak MD, Howieson DB, Loring DW. Executive Functions and Motor Performance. Neuropsychological assessment, fourth )] TJ ET BT 26.250 329.143 Td /F1 9.8 Tf [(ed. New York: Oxford University Press, 2004:611-646.)] TJ ET BT 26.250 309.738 Td /F1 9.8 Tf [(27.)] TJ ET BT 43.553 309.738 Td /F1 9.8 Tf [(Reitan RM. The relation of the trail making test to organic brain damage. J Consult Psychol 1955;19:393-394.)] TJ ET BT 26.250 290.334 Td /F1 9.8 Tf [(28.)] TJ ET BT 43.553 290.334 Td /F1 9.8 Tf [(Stroop JR. Studies of interference in serial verbal reactions. Journal of Experimental Psychology 1935;18:643-662.)] TJ ET BT 26.250 270.929 Td /F1 9.8 Tf [(29.)] TJ ET BT 43.553 270.929 Td /F1 9.8 Tf [(Derogatis LR. SCL-90-R Symptom Checklist 90-R. Copenhagen: Psykologisk Forlag A/S, 1977.)] TJ ET BT 26.250 251.524 Td /F1 9.8 Tf [(30.)] TJ ET BT 43.553 251.524 Td /F1 9.8 Tf [(Chatterjee A, Anderson KE, Moskowitz CB, Hauser WA, Marder KS. A comparison of self-report and caregiver assessment )] TJ ET BT 26.250 239.619 Td /F1 9.8 Tf [(of depression, apathy, and irritability in Huntington's disease. The Journal of neuropsychiatry and clinical neurosciences )] TJ ET BT 26.250 227.715 Td /F1 9.8 Tf [(2014;17:378-383.)] TJ ET BT 26.250 208.310 Td /F1 9.8 Tf [(31.)] TJ ET BT 43.553 208.310 Td /F1 9.8 Tf [(Sitek EJ, Thompson JC, Craufurd D, Snowden JS. Unawareness of Deficits in Huntington's Disease. Journal of )] TJ ET BT 26.250 196.405 Td /F1 9.8 Tf [(Huntington's disease 2014;3:125-135.)] TJ ET BT 26.250 177.000 Td /F1 9.8 Tf [(32.)] TJ ET BT 43.553 177.000 Td /F1 9.8 Tf [(O'Keeffe FM, Murray B, Coen RF, et al. Loss of insight in frontotemporal dementia, corticobasal degeneration and )] TJ ET BT 26.250 165.096 Td /F1 9.8 Tf [(progressive supranuclear palsy. Brain 2007;130:753-764.)] TJ ET BT 26.250 145.691 Td /F1 9.8 Tf [(33.)] TJ ET BT 43.553 145.691 Td /F1 9.8 Tf [(Decety J, Sommerville JA. Shared representations between self and other: a social cognitive neuroscience view. Trends in )] TJ ET BT 26.250 133.786 Td /F1 9.8 Tf [(cognitive sciences 2003;7:527-533.)] TJ ET BT 26.250 114.381 Td /F1 9.8 Tf [(34.)] TJ ET BT 43.553 114.381 Td /F1 9.8 Tf [(Gallagher S, Meltzoff AN. The earliest sense of self and others: Merleau-Ponty and recent developmental studies. )] TJ ET BT 26.250 102.477 Td /F1 9.8 Tf [(Philosophical psychology 1996;9:211-233.)] TJ ET BT 26.250 83.072 Td /F1 9.8 Tf [(35.)] TJ ET BT 43.553 83.072 Td /F1 9.8 Tf [(Abu-Akel A. A neurobiological mapping of theory of mind. Brain research reviews 2003;43:29-40.)] TJ ET BT 26.250 63.667 Td /F1 9.8 Tf [(36.)] TJ ET BT 43.553 63.667 Td /F1 9.8 Tf [(Abu-Akel A, Shamay-Tsoory S. Neuroanatomical and neurochemical bases of theory of mind. Neuropsychologia )] TJ ET BT 26.250 51.762 Td /F1 9.8 Tf [(2011;49:2971-2984.)] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(9)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Huntington Disease)] TJ ET Q endstream endobj 533 0 obj << /Type /Page /Parent 3 0 R /Contents 534 0 R >> endobj 534 0 obj << /Length 14231 >> stream 0.271 0.267 0.267 rg q 15.000 292.357 577.500 484.643 re W n 0.271 0.267 0.267 rg BT 26.250 759.976 Td /F1 9.8 Tf [(37.)] TJ ET BT 43.553 759.976 Td /F1 9.8 Tf [(Lieberman MD. Social cognitive neuroscience: a review of core processes. Annual Review of Psychology 2007;58:259-289.)] TJ ET BT 26.250 740.571 Td /F1 9.8 Tf [(38.)] TJ ET BT 43.553 740.571 Td /F1 9.8 Tf [(Tabrizi SJ, Scahill RI, Owen G, et al. Predictors of phenotypic progression and disease onset in premanifest and early-stage )] TJ ET BT 26.250 728.667 Td /F1 9.8 Tf [(Huntington's disease in the TRACK-HD study: analysis of 36-month observational data. Lancet Neurol 2013 Jul;12:637-649.)] TJ ET BT 26.250 709.262 Td /F1 9.8 Tf [(39.)] TJ ET BT 43.553 709.262 Td /F1 9.8 Tf [(Thompson JC, Harris J, Sollom AC, et al. Longitudinal evaluation of neuropsychiatric symptoms in Huntington's disease. )] TJ ET BT 26.250 697.357 Td /F1 9.8 Tf [(Journal of Neuropsychiatry and Clinical Neuroscience 2012;24:53-60.)] TJ ET BT 26.250 677.952 Td /F1 9.8 Tf [(40.)] TJ ET BT 43.553 677.952 Td /F1 9.8 Tf [(Ehrlich S, Yendiki A, Greve DN, et al. Striatal function in relation to negative symptoms in schizophrenia. Psychological )] TJ ET BT 26.250 666.048 Td /F1 9.8 Tf [(medicine 2012;42:267-282.)] TJ ET BT 26.250 646.643 Td /F1 9.8 Tf [(41.)] TJ ET BT 43.553 646.643 Td /F1 9.8 Tf [(Eslinger PJ, Dennis K, Moore P, Antani S, Hauck R, Grossman M. Metacognitive deficits in frontotemporal dementia. )] TJ ET BT 26.250 634.738 Td /F1 9.8 Tf [(Journal of Neurology, Neurosurgery & Psychiatry 2005;76:1630-1635.)] TJ ET BT 26.250 615.333 Td /F1 9.8 Tf [(42.)] TJ ET BT 43.553 615.333 Td /F1 9.8 Tf [(Konstantakopoulos G, Ploumpidis D, Oulis P, et al. The relationship between insight and theory of mind in schizophrenia. )] TJ ET BT 26.250 603.429 Td /F1 9.8 Tf [(Schizophrenia research 2014;152:217-222.)] TJ ET BT 26.250 584.024 Td /F1 9.8 Tf [(43.)] TJ ET BT 43.553 584.024 Td /F1 9.8 Tf [(Hoth KF, Paulsen JS, Moser DJ, Tranel D, Clark LA, Bechara A. Patients with Huntington's disease have impaired )] TJ ET BT 26.250 572.119 Td /F1 9.8 Tf [(awareness of cognitive, emotional, and functional abilities. J Clin Exp Neuropsychol 2007 May;29:365-376.)] TJ ET BT 26.250 552.714 Td /F1 9.8 Tf [(44.)] TJ ET BT 43.553 552.714 Td /F1 9.8 Tf [(McCusker EA, Gunn DG, Epping EA, et al. Unawareness of motor phenoconversion in Huntington disease. Neurology )] TJ ET BT 26.250 540.810 Td /F1 9.8 Tf [(2013;81:1141-1147.)] TJ ET BT 26.250 521.405 Td /F1 9.8 Tf [(45.)] TJ ET BT 43.553 521.405 Td /F1 9.8 Tf [(Ng R, Fish S, Granholm E. Insight and theory of mind in schizophrenia. Psychiatry Res. 2015 Jan 30;225\(1-2\):169-74. )] TJ ET BT 26.250 509.500 Td /F1 9.8 Tf [(PubMed PMID:25467703.)] TJ ET BT 26.250 490.095 Td /F1 9.8 Tf [(46.)] TJ ET BT 43.553 490.095 Td /F1 9.8 Tf [(Santangelo G, Vitale C, Trojano L, et al. Neuropsychological correlates of theory of mind in patients with early Parkinson's )] TJ ET BT 26.250 478.191 Td /F1 9.8 Tf [(disease. Movement Disorders 2012;27:98-105.)] TJ ET BT 26.250 458.786 Td /F1 9.8 Tf [(47.)] TJ ET BT 43.553 458.786 Td /F1 9.8 Tf [(Thompson JC, Snowden JS, Craufurd D, Neary D. Behavior in Huntington's disease: dissociating cognition-based and )] TJ ET BT 26.250 446.881 Td /F1 9.8 Tf [(mood-based changes. J Neuropsychiatry Clin Neurosci 2002;14:37-43.)] TJ ET BT 26.250 427.476 Td /F1 9.8 Tf [(48.)] TJ ET BT 43.553 427.476 Td /F1 9.8 Tf [(Eddy CM, Rickards HE. Interaction without intent: The shape of the social world in Huntington's disease. Social cognitive )] TJ ET BT 26.250 415.572 Td /F1 9.8 Tf [(and affective neuroscience 2015;10:1028-1035.)] TJ ET BT 26.250 396.167 Td /F1 9.8 Tf [(49.)] TJ ET BT 43.553 396.167 Td /F1 9.8 Tf [(Brune M, Blank K, Witthaus H, Saft C. "Theory of mind" is impaired in Huntington's disease. Mov Disord 2011 Mar;26:671-)] TJ ET BT 26.250 384.262 Td /F1 9.8 Tf [(678.)] TJ ET BT 26.250 364.857 Td /F1 9.8 Tf [(50.)] TJ ET BT 43.553 364.857 Td /F1 9.8 Tf [(Olsen LR, Mortensen EL, Bech P: Mental distress in the Danish general population. Acta Psychiatr Scand 2006, 113:477-)] TJ ET BT 26.250 352.953 Td /F1 9.8 Tf [(484)] TJ ET BT 26.250 333.548 Td /F1 9.8 Tf [(51.)] TJ ET BT 43.553 333.548 Td /F1 9.8 Tf [(The Awareness of Social Inference Test \(TASIT\): Danish Translation Copyright \(2008\) by Skye McDonald, Sharon )] TJ ET BT 26.250 321.643 Td /F1 9.8 Tf [(Flanagan and Jennifer Rollins, published by Pearson Assessment; Copyright 2011 by Skye McDonald, Sharon Flanagan and )] TJ ET BT 26.250 309.738 Td /F1 9.8 Tf [(Jennifer Rollins. Reproduced with permission from Pearson Assessment. All rights reserved.)] TJ ET Q q 15.000 292.357 577.500 484.643 re W n 0.271 0.267 0.267 rg BT 26.250 759.976 Td /F1 9.8 Tf [(37.)] TJ ET BT 43.553 759.976 Td /F1 9.8 Tf [(Lieberman MD. Social cognitive neuroscience: a review of core processes. Annual Review of Psychology 2007;58:259-289.)] TJ ET BT 26.250 740.571 Td /F1 9.8 Tf [(38.)] TJ ET BT 43.553 740.571 Td /F1 9.8 Tf [(Tabrizi SJ, Scahill RI, Owen G, et al. Predictors of phenotypic progression and disease onset in premanifest and early-stage )] TJ ET BT 26.250 728.667 Td /F1 9.8 Tf [(Huntington's disease in the TRACK-HD study: analysis of 36-month observational data. Lancet Neurol 2013 Jul;12:637-649.)] TJ ET BT 26.250 709.262 Td /F1 9.8 Tf [(39.)] TJ ET BT 43.553 709.262 Td /F1 9.8 Tf [(Thompson JC, Harris J, Sollom AC, et al. Longitudinal evaluation of neuropsychiatric symptoms in Huntington's disease. )] TJ ET BT 26.250 697.357 Td /F1 9.8 Tf [(Journal of Neuropsychiatry and Clinical Neuroscience 2012;24:53-60.)] TJ ET BT 26.250 677.952 Td /F1 9.8 Tf [(40.)] TJ ET BT 43.553 677.952 Td /F1 9.8 Tf [(Ehrlich S, Yendiki A, Greve DN, et al. Striatal function in relation to negative symptoms in schizophrenia. Psychological )] TJ ET BT 26.250 666.048 Td /F1 9.8 Tf [(medicine 2012;42:267-282.)] TJ ET BT 26.250 646.643 Td /F1 9.8 Tf [(41.)] TJ ET BT 43.553 646.643 Td /F1 9.8 Tf [(Eslinger PJ, Dennis K, Moore P, Antani S, Hauck R, Grossman M. Metacognitive deficits in frontotemporal dementia. )] TJ ET BT 26.250 634.738 Td /F1 9.8 Tf [(Journal of Neurology, Neurosurgery & Psychiatry 2005;76:1630-1635.)] TJ ET BT 26.250 615.333 Td /F1 9.8 Tf [(42.)] TJ ET BT 43.553 615.333 Td /F1 9.8 Tf [(Konstantakopoulos G, Ploumpidis D, Oulis P, et al. The relationship between insight and theory of mind in schizophrenia. )] TJ ET BT 26.250 603.429 Td /F1 9.8 Tf [(Schizophrenia research 2014;152:217-222.)] TJ ET BT 26.250 584.024 Td /F1 9.8 Tf [(43.)] TJ ET BT 43.553 584.024 Td /F1 9.8 Tf [(Hoth KF, Paulsen JS, Moser DJ, Tranel D, Clark LA, Bechara A. Patients with Huntington's disease have impaired )] TJ ET BT 26.250 572.119 Td /F1 9.8 Tf [(awareness of cognitive, emotional, and functional abilities. J Clin Exp Neuropsychol 2007 May;29:365-376.)] TJ ET BT 26.250 552.714 Td /F1 9.8 Tf [(44.)] TJ ET BT 43.553 552.714 Td /F1 9.8 Tf [(McCusker EA, Gunn DG, Epping EA, et al. Unawareness of motor phenoconversion in Huntington disease. Neurology )] TJ ET BT 26.250 540.810 Td /F1 9.8 Tf [(2013;81:1141-1147.)] TJ ET BT 26.250 521.405 Td /F1 9.8 Tf [(45.)] TJ ET BT 43.553 521.405 Td /F1 9.8 Tf [(Ng R, Fish S, Granholm E. Insight and theory of mind in schizophrenia. Psychiatry Res. 2015 Jan 30;225\(1-2\):169-74. )] TJ ET BT 26.250 509.500 Td /F1 9.8 Tf [(PubMed PMID:25467703.)] TJ ET BT 26.250 490.095 Td /F1 9.8 Tf [(46.)] TJ ET BT 43.553 490.095 Td /F1 9.8 Tf [(Santangelo G, Vitale C, Trojano L, et al. Neuropsychological correlates of theory of mind in patients with early Parkinson's )] TJ ET BT 26.250 478.191 Td /F1 9.8 Tf [(disease. Movement Disorders 2012;27:98-105.)] TJ ET BT 26.250 458.786 Td /F1 9.8 Tf [(47.)] TJ ET BT 43.553 458.786 Td /F1 9.8 Tf [(Thompson JC, Snowden JS, Craufurd D, Neary D. Behavior in Huntington's disease: dissociating cognition-based and )] TJ ET BT 26.250 446.881 Td /F1 9.8 Tf [(mood-based changes. J Neuropsychiatry Clin Neurosci 2002;14:37-43.)] TJ ET BT 26.250 427.476 Td /F1 9.8 Tf [(48.)] TJ ET BT 43.553 427.476 Td /F1 9.8 Tf [(Eddy CM, Rickards HE. Interaction without intent: The shape of the social world in Huntington's disease. Social cognitive )] TJ ET BT 26.250 415.572 Td /F1 9.8 Tf [(and affective neuroscience 2015;10:1028-1035.)] TJ ET BT 26.250 396.167 Td /F1 9.8 Tf [(49.)] TJ ET BT 43.553 396.167 Td /F1 9.8 Tf [(Brune M, Blank K, Witthaus H, Saft C. "Theory of mind" is impaired in Huntington's disease. Mov Disord 2011 Mar;26:671-)] TJ ET BT 26.250 384.262 Td /F1 9.8 Tf [(678.)] TJ ET BT 26.250 364.857 Td /F1 9.8 Tf [(50.)] TJ ET BT 43.553 364.857 Td /F1 9.8 Tf [(Olsen LR, Mortensen EL, Bech P: Mental distress in the Danish general population. Acta Psychiatr Scand 2006, 113:477-)] TJ ET BT 26.250 352.953 Td /F1 9.8 Tf [(484)] TJ ET BT 26.250 333.548 Td /F1 9.8 Tf [(51.)] TJ ET BT 43.553 333.548 Td /F1 9.8 Tf [(The Awareness of Social Inference Test \(TASIT\): Danish Translation Copyright \(2008\) by Skye McDonald, Sharon )] TJ ET BT 26.250 321.643 Td /F1 9.8 Tf [(Flanagan and Jennifer Rollins, published by Pearson Assessment; Copyright 2011 by Skye McDonald, Sharon Flanagan and )] TJ ET BT 26.250 309.738 Td /F1 9.8 Tf [(Jennifer Rollins. Reproduced with permission from Pearson Assessment. All rights reserved.)] TJ ET Q q 15.000 292.357 577.500 484.643 re W n 0.271 0.267 0.267 rg BT 26.250 759.976 Td /F1 9.8 Tf [(37.)] TJ ET BT 43.553 759.976 Td /F1 9.8 Tf [(Lieberman MD. Social cognitive neuroscience: a review of core processes. Annual Review of Psychology 2007;58:259-289.)] TJ ET BT 26.250 740.571 Td /F1 9.8 Tf [(38.)] TJ ET BT 43.553 740.571 Td /F1 9.8 Tf [(Tabrizi SJ, Scahill RI, Owen G, et al. Predictors of phenotypic progression and disease onset in premanifest and early-stage )] TJ ET BT 26.250 728.667 Td /F1 9.8 Tf [(Huntington's disease in the TRACK-HD study: analysis of 36-month observational data. Lancet Neurol 2013 Jul;12:637-649.)] TJ ET BT 26.250 709.262 Td /F1 9.8 Tf [(39.)] TJ ET BT 43.553 709.262 Td /F1 9.8 Tf [(Thompson JC, Harris J, Sollom AC, et al. Longitudinal evaluation of neuropsychiatric symptoms in Huntington's disease. )] TJ ET BT 26.250 697.357 Td /F1 9.8 Tf [(Journal of Neuropsychiatry and Clinical Neuroscience 2012;24:53-60.)] TJ ET BT 26.250 677.952 Td /F1 9.8 Tf [(40.)] TJ ET BT 43.553 677.952 Td /F1 9.8 Tf [(Ehrlich S, Yendiki A, Greve DN, et al. Striatal function in relation to negative symptoms in schizophrenia. Psychological )] TJ ET BT 26.250 666.048 Td /F1 9.8 Tf [(medicine 2012;42:267-282.)] TJ ET BT 26.250 646.643 Td /F1 9.8 Tf [(41.)] TJ ET BT 43.553 646.643 Td /F1 9.8 Tf [(Eslinger PJ, Dennis K, Moore P, Antani S, Hauck R, Grossman M. Metacognitive deficits in frontotemporal dementia. )] TJ ET BT 26.250 634.738 Td /F1 9.8 Tf [(Journal of Neurology, Neurosurgery & Psychiatry 2005;76:1630-1635.)] TJ ET BT 26.250 615.333 Td /F1 9.8 Tf [(42.)] TJ ET BT 43.553 615.333 Td /F1 9.8 Tf [(Konstantakopoulos G, Ploumpidis D, Oulis P, et al. The relationship between insight and theory of mind in schizophrenia. )] TJ ET BT 26.250 603.429 Td /F1 9.8 Tf [(Schizophrenia research 2014;152:217-222.)] TJ ET BT 26.250 584.024 Td /F1 9.8 Tf [(43.)] TJ ET BT 43.553 584.024 Td /F1 9.8 Tf [(Hoth KF, Paulsen JS, Moser DJ, Tranel D, Clark LA, Bechara A. Patients with Huntington's disease have impaired )] TJ ET BT 26.250 572.119 Td /F1 9.8 Tf [(awareness of cognitive, emotional, and functional abilities. J Clin Exp Neuropsychol 2007 May;29:365-376.)] TJ ET BT 26.250 552.714 Td /F1 9.8 Tf [(44.)] TJ ET BT 43.553 552.714 Td /F1 9.8 Tf [(McCusker EA, Gunn DG, Epping EA, et al. Unawareness of motor phenoconversion in Huntington disease. Neurology )] TJ ET BT 26.250 540.810 Td /F1 9.8 Tf [(2013;81:1141-1147.)] TJ ET BT 26.250 521.405 Td /F1 9.8 Tf [(45.)] TJ ET BT 43.553 521.405 Td /F1 9.8 Tf [(Ng R, Fish S, Granholm E. Insight and theory of mind in schizophrenia. Psychiatry Res. 2015 Jan 30;225\(1-2\):169-74. )] TJ ET BT 26.250 509.500 Td /F1 9.8 Tf [(PubMed PMID:25467703.)] TJ ET BT 26.250 490.095 Td /F1 9.8 Tf [(46.)] TJ ET BT 43.553 490.095 Td /F1 9.8 Tf [(Santangelo G, Vitale C, Trojano L, et al. Neuropsychological correlates of theory of mind in patients with early Parkinson's )] TJ ET BT 26.250 478.191 Td /F1 9.8 Tf [(disease. Movement Disorders 2012;27:98-105.)] TJ ET BT 26.250 458.786 Td /F1 9.8 Tf [(47.)] TJ ET BT 43.553 458.786 Td /F1 9.8 Tf [(Thompson JC, Snowden JS, Craufurd D, Neary D. Behavior in Huntington's disease: dissociating cognition-based and )] TJ ET BT 26.250 446.881 Td /F1 9.8 Tf [(mood-based changes. J Neuropsychiatry Clin Neurosci 2002;14:37-43.)] TJ ET BT 26.250 427.476 Td /F1 9.8 Tf [(48.)] TJ ET BT 43.553 427.476 Td /F1 9.8 Tf [(Eddy CM, Rickards HE. Interaction without intent: The shape of the social world in Huntington's disease. Social cognitive )] TJ ET BT 26.250 415.572 Td /F1 9.8 Tf [(and affective neuroscience 2015;10:1028-1035.)] TJ ET BT 26.250 396.167 Td /F1 9.8 Tf [(49.)] TJ ET BT 43.553 396.167 Td /F1 9.8 Tf [(Brune M, Blank K, Witthaus H, Saft C. "Theory of mind" is impaired in Huntington's disease. Mov Disord 2011 Mar;26:671-)] TJ ET BT 26.250 384.262 Td /F1 9.8 Tf [(678.)] TJ ET BT 26.250 364.857 Td /F1 9.8 Tf [(50.)] TJ ET BT 43.553 364.857 Td /F1 9.8 Tf [(Olsen LR, Mortensen EL, Bech P: Mental distress in the Danish general population. Acta Psychiatr Scand 2006, 113:477-)] TJ ET BT 26.250 352.953 Td /F1 9.8 Tf [(484)] TJ ET BT 26.250 333.548 Td /F1 9.8 Tf [(51.)] TJ ET BT 43.553 333.548 Td /F1 9.8 Tf [(The Awareness of Social Inference Test \(TASIT\): Danish Translation Copyright \(2008\) by Skye McDonald, Sharon )] TJ ET BT 26.250 321.643 Td /F1 9.8 Tf [(Flanagan and Jennifer Rollins, published by Pearson Assessment; Copyright 2011 by Skye McDonald, Sharon Flanagan and )] TJ ET BT 26.250 309.738 Td /F1 9.8 Tf [(Jennifer Rollins. Reproduced with permission from Pearson Assessment. All rights reserved.)] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(10)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Huntington Disease)] TJ ET Q endstream endobj xref 0 535 0000000000 65535 f 0000000008 00000 n 0000000073 00000 n 0000000119 00000 n 0000000476 00000 n 0000000513 00000 n 0000000775 00000 n 0000001503 00000 n 0000032044 00000 n 0000032151 00000 n 0000032259 00000 n 0000032370 00000 n 0000032483 00000 n 0000032871 00000 n 0000037352 00000 n 0000037479 00000 n 0000037686 00000 n 0000037813 00000 n 0000038020 00000 n 0000038148 00000 n 0000038262 00000 n 0000038389 00000 n 0000038486 00000 n 0000038614 00000 n 0000038721 00000 n 0000038849 00000 n 0000038951 00000 n 0000039079 00000 n 0000039187 00000 n 0000039315 00000 n 0000039427 00000 n 0000039555 00000 n 0000039591 00000 n 0000039719 00000 n 0000039755 00000 n 0000039883 00000 n 0000039919 00000 n 0000040047 00000 n 0000040083 00000 n 0000040211 00000 n 0000040247 00000 n 0000040373 00000 n 0000040409 00000 n 0000040535 00000 n 0000040571 00000 n 0000040699 00000 n 0000040735 00000 n 0000040863 00000 n 0000040899 00000 n 0000041027 00000 n 0000041063 00000 n 0000041191 00000 n 0000041227 00000 n 0000041355 00000 n 0000041391 00000 n 0000041517 00000 n 0000041553 00000 n 0000041680 00000 n 0000041716 00000 n 0000041843 00000 n 0000041879 00000 n 0000042006 00000 n 0000042042 00000 n 0000042169 00000 n 0000042205 00000 n 0000042332 00000 n 0000042368 00000 n 0000042495 00000 n 0000042531 00000 n 0000042657 00000 n 0000042693 00000 n 0000042819 00000 n 0000042855 00000 n 0000042982 00000 n 0000043189 00000 n 0000043316 00000 n 0000043523 00000 n 0000043651 00000 n 0000043765 00000 n 0000043892 00000 n 0000043989 00000 n 0000044117 00000 n 0000044224 00000 n 0000044352 00000 n 0000044454 00000 n 0000044582 00000 n 0000044690 00000 n 0000044818 00000 n 0000044930 00000 n 0000045058 00000 n 0000045094 00000 n 0000045222 00000 n 0000045258 00000 n 0000045386 00000 n 0000045422 00000 n 0000045550 00000 n 0000045586 00000 n 0000045714 00000 n 0000045750 00000 n 0000045876 00000 n 0000045912 00000 n 0000046040 00000 n 0000046077 00000 n 0000046207 00000 n 0000046244 00000 n 0000046374 00000 n 0000046411 00000 n 0000046541 00000 n 0000046578 00000 n 0000046708 00000 n 0000046745 00000 n 0000046875 00000 n 0000046912 00000 n 0000047040 00000 n 0000047077 00000 n 0000047206 00000 n 0000047243 00000 n 0000047372 00000 n 0000047409 00000 n 0000047538 00000 n 0000047575 00000 n 0000047704 00000 n 0000047741 00000 n 0000047870 00000 n 0000047907 00000 n 0000048036 00000 n 0000048073 00000 n 0000048201 00000 n 0000048238 00000 n 0000048366 00000 n 0000048403 00000 n 0000048532 00000 n 0000048740 00000 n 0000048869 00000 n 0000049077 00000 n 0000049207 00000 n 0000049322 00000 n 0000049451 00000 n 0000049549 00000 n 0000049679 00000 n 0000049787 00000 n 0000049917 00000 n 0000050020 00000 n 0000050150 00000 n 0000050259 00000 n 0000050389 00000 n 0000050502 00000 n 0000050632 00000 n 0000050669 00000 n 0000050799 00000 n 0000050836 00000 n 0000050966 00000 n 0000051003 00000 n 0000051133 00000 n 0000051170 00000 n 0000051300 00000 n 0000051337 00000 n 0000051465 00000 n 0000051502 00000 n 0000051630 00000 n 0000051667 00000 n 0000051797 00000 n 0000051834 00000 n 0000051964 00000 n 0000052001 00000 n 0000052131 00000 n 0000052168 00000 n 0000052298 00000 n 0000052335 00000 n 0000052465 00000 n 0000052502 00000 n 0000052630 00000 n 0000052667 00000 n 0000052796 00000 n 0000052833 00000 n 0000052962 00000 n 0000052999 00000 n 0000053128 00000 n 0000053165 00000 n 0000053294 00000 n 0000053331 00000 n 0000053460 00000 n 0000053497 00000 n 0000053626 00000 n 0000053663 00000 n 0000053791 00000 n 0000053828 00000 n 0000053956 00000 n 0000053993 00000 n 0000054240 00000 n 0000071497 00000 n 0000071627 00000 n 0000071664 00000 n 0000071792 00000 n 0000071829 00000 n 0000071959 00000 n 0000071996 00000 n 0000072126 00000 n 0000072163 00000 n 0000072293 00000 n 0000072330 00000 n 0000072460 00000 n 0000072497 00000 n 0000072626 00000 n 0000072740 00000 n 0000108721 00000 n 0000108851 00000 n 0000108888 00000 n 0000109016 00000 n 0000109053 00000 n 0000109183 00000 n 0000109220 00000 n 0000109350 00000 n 0000109387 00000 n 0000109517 00000 n 0000109554 00000 n 0000109684 00000 n 0000109721 00000 n 0000109850 00000 n 0000109964 00000 n 0000110094 00000 n 0000110131 00000 n 0000110259 00000 n 0000110296 00000 n 0000110426 00000 n 0000110463 00000 n 0000110593 00000 n 0000110630 00000 n 0000110760 00000 n 0000110797 00000 n 0000110927 00000 n 0000110964 00000 n 0000111093 00000 n 0000111207 00000 n 0000111526 00000 n 0000142230 00000 n 0000142360 00000 n 0000142397 00000 n 0000142527 00000 n 0000142564 00000 n 0000142694 00000 n 0000142731 00000 n 0000142861 00000 n 0000142898 00000 n 0000143028 00000 n 0000143065 00000 n 0000143195 00000 n 0000143232 00000 n 0000143362 00000 n 0000143399 00000 n 0000143528 00000 n 0000143565 00000 n 0000143693 00000 n 0000143730 00000 n 0000143858 00000 n 0000143895 00000 n 0000144025 00000 n 0000144062 00000 n 0000144192 00000 n 0000144229 00000 n 0000144359 00000 n 0000144396 00000 n 0000144526 00000 n 0000144563 00000 n 0000144693 00000 n 0000144730 00000 n 0000144860 00000 n 0000144897 00000 n 0000145027 00000 n 0000145064 00000 n 0000145193 00000 n 0000145230 00000 n 0000145358 00000 n 0000145395 00000 n 0000145523 00000 n 0000145560 00000 n 0000145690 00000 n 0000145727 00000 n 0000145857 00000 n 0000145894 00000 n 0000146024 00000 n 0000146061 00000 n 0000146191 00000 n 0000146228 00000 n 0000146358 00000 n 0000146395 00000 n 0000146525 00000 n 0000146562 00000 n 0000146692 00000 n 0000146729 00000 n 0000146858 00000 n 0000146895 00000 n 0000147023 00000 n 0000147060 00000 n 0000147188 00000 n 0000147225 00000 n 0000147376 00000 n 0000160803 00000 n 0000160933 00000 n 0000160970 00000 n 0000161100 00000 n 0000161137 00000 n 0000161267 00000 n 0000161381 00000 n 0000223763 00000 n 0000223893 00000 n 0000223930 00000 n 0000224060 00000 n 0000224097 00000 n 0000224227 00000 n 0000224341 00000 n 0000224471 00000 n 0000224508 00000 n 0000224638 00000 n 0000224675 00000 n 0000224805 00000 n 0000224919 00000 n 0000225046 00000 n 0000234226 00000 n 0000234355 00000 n 0000234469 00000 n 0000267739 00000 n 0000267869 00000 n 0000267983 00000 n 0000323809 00000 n 0000323938 00000 n 0000324052 00000 n 0000324182 00000 n 0000324296 00000 n 0000324425 00000 n 0000324539 00000 n 0000324669 00000 n 0000324783 00000 n 0000325102 00000 n 0000346418 00000 n 0000346547 00000 n 0000346661 00000 n 0000397200 00000 n 0000397330 00000 n 0000397367 00000 n 0000397497 00000 n 0000397534 00000 n 0000397664 00000 n 0000397701 00000 n 0000397829 00000 n 0000397866 00000 n 0000397995 00000 n 0000398032 00000 n 0000398158 00000 n 0000398195 00000 n 0000398321 00000 n 0000398358 00000 n 0000398484 00000 n 0000398521 00000 n 0000398647 00000 n 0000398684 00000 n 0000398813 00000 n 0000398927 00000 n 0000399057 00000 n 0000399094 00000 n 0000399224 00000 n 0000399261 00000 n 0000399391 00000 n 0000399428 00000 n 0000399556 00000 n 0000399593 00000 n 0000399722 00000 n 0000399759 00000 n 0000399885 00000 n 0000399922 00000 n 0000400048 00000 n 0000400085 00000 n 0000400211 00000 n 0000400248 00000 n 0000400374 00000 n 0000400411 00000 n 0000400540 00000 n 0000400654 00000 n 0000400784 00000 n 0000400821 00000 n 0000400951 00000 n 0000400988 00000 n 0000401118 00000 n 0000401155 00000 n 0000401283 00000 n 0000401320 00000 n 0000401449 00000 n 0000401486 00000 n 0000401612 00000 n 0000401649 00000 n 0000401775 00000 n 0000401812 00000 n 0000401938 00000 n 0000401975 00000 n 0000402101 00000 n 0000402138 00000 n 0000402745 00000 n 0000437406 00000 n 0000437536 00000 n 0000437573 00000 n 0000437703 00000 n 0000437740 00000 n 0000437870 00000 n 0000437907 00000 n 0000438037 00000 n 0000438074 00000 n 0000438204 00000 n 0000438241 00000 n 0000438369 00000 n 0000438406 00000 n 0000438534 00000 n 0000438571 00000 n 0000438699 00000 n 0000438736 00000 n 0000438865 00000 n 0000438902 00000 n 0000439032 00000 n 0000439069 00000 n 0000439199 00000 n 0000439236 00000 n 0000439366 00000 n 0000439403 00000 n 0000439533 00000 n 0000439570 00000 n 0000439700 00000 n 0000439737 00000 n 0000439867 00000 n 0000439904 00000 n 0000440034 00000 n 0000440071 00000 n 0000440201 00000 n 0000440238 00000 n 0000440368 00000 n 0000440405 00000 n 0000440535 00000 n 0000440572 00000 n 0000440702 00000 n 0000440739 00000 n 0000440869 00000 n 0000440906 00000 n 0000441036 00000 n 0000441073 00000 n 0000441203 00000 n 0000441240 00000 n 0000441370 00000 n 0000441407 00000 n 0000441537 00000 n 0000441574 00000 n 0000441704 00000 n 0000441741 00000 n 0000441871 00000 n 0000441908 00000 n 0000442036 00000 n 0000442073 00000 n 0000442201 00000 n 0000442238 00000 n 0000442366 00000 n 0000442403 00000 n 0000442532 00000 n 0000442569 00000 n 0000442699 00000 n 0000442736 00000 n 0000442866 00000 n 0000442903 00000 n 0000443033 00000 n 0000443070 00000 n 0000443200 00000 n 0000443237 00000 n 0000443367 00000 n 0000443404 00000 n 0000443534 00000 n 0000443571 00000 n 0000443701 00000 n 0000443738 00000 n 0000443868 00000 n 0000443905 00000 n 0000444035 00000 n 0000444072 00000 n 0000444202 00000 n 0000444239 00000 n 0000444369 00000 n 0000444406 00000 n 0000444536 00000 n 0000444573 00000 n 0000444703 00000 n 0000444740 00000 n 0000444870 00000 n 0000444907 00000 n 0000445037 00000 n 0000445074 00000 n 0000445204 00000 n 0000445241 00000 n 0000445371 00000 n 0000445408 00000 n 0000445538 00000 n 0000445575 00000 n 0000445703 00000 n 0000445740 00000 n 0000445868 00000 n 0000445905 00000 n 0000446033 00000 n 0000446070 00000 n 0000446199 00000 n 0000446236 00000 n 0000446366 00000 n 0000446403 00000 n 0000446533 00000 n 0000446570 00000 n 0000446700 00000 n 0000446737 00000 n 0000446867 00000 n 0000446904 00000 n 0000447034 00000 n 0000447071 00000 n 0000447201 00000 n 0000447238 00000 n 0000447368 00000 n 0000447405 00000 n 0000447535 00000 n 0000447572 00000 n 0000447702 00000 n 0000447739 00000 n 0000447869 00000 n 0000447906 00000 n 0000448036 00000 n 0000448073 00000 n 0000448203 00000 n 0000448240 00000 n 0000448370 00000 n 0000448407 00000 n 0000448474 00000 n 0000467514 00000 n 0000467581 00000 n 0000489144 00000 n 0000489211 00000 n trailer << /Size 535 /Root 1 0 R /Info 5 0 R >> startxref 503497 %%EOF