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/Title (NMDA receptor gene variations as modifiers in Huntington disease: a replication study � PLOS Currents Huntington Disease)
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15.000 684.354 577.500 53.646 re W n
0.267 0.267 0.267 rg
BT 15.000 718.042 Td /F2 21.0 Tf  [(NMDA receptor gene variations as modifiers in Huntington )] TJ ET
BT 15.000 693.094 Td /F2 21.0 Tf  [(disease: a replication study)] TJ ET
Q
0.271 0.267 0.267 rg
BT 15.000 675.088 Td /F3 9.8 Tf  [(July 11, 2011)] TJ ET
BT 72.681 675.088 Td /F3 9.8 Tf  [(�)] TJ ET
0.267 0.267 0.267 rg
BT 77.556 675.088 Td /F3 9.8 Tf  [(Genetics)] TJ ET
BT 26.250 663.247 Td /F1 9.8 Tf  [(Carsten Saft)] TJ ET
0.271 0.267 0.267 rg
BT 80.441 663.247 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 85.862 663.247 Td /F1 9.8 Tf  [(jorgtepplen)] TJ ET
0.271 0.267 0.267 rg
BT 134.095 663.247 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 139.516 663.247 Td /F1 9.8 Tf  [(Stefan Wieczorek)] TJ ET
0.271 0.267 0.267 rg
BT 215.917 663.247 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 221.338 663.247 Td /F1 9.8 Tf  [(G. Bernhard Landwehrmeyer)] TJ ET
0.271 0.267 0.267 rg
BT 347.054 663.247 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 352.475 663.247 Td /F1 9.8 Tf  [(Raymund A.C. Roos)] TJ ET
0.271 0.267 0.267 rg
BT 441.337 663.247 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 446.758 663.247 Td /F1 9.8 Tf  [(Justo Garcia de Yebenes)] TJ ET
0.271 0.267 0.267 rg
BT 556.231 663.247 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 26.250 651.342 Td /F1 9.8 Tf  [(Matthias Dose)] TJ ET
0.271 0.267 0.267 rg
BT 88.562 651.342 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 93.983 651.342 Td /F1 9.8 Tf  [(Sarah J Tabrizi)] TJ ET
0.271 0.267 0.267 rg
BT 159.542 651.342 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 164.963 651.342 Td /F1 9.8 Tf  [(David Craufurd)] TJ ET
0.271 0.267 0.267 rg
BT 230.522 651.342 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 235.943 651.342 Td /F1 9.8 Tf  [(the REGISTRY investigators of the European Huntington's Disease Network)] TJ ET
0.271 0.267 0.267 rg
BT 564.567 651.342 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 26.250 639.438 Td /F1 9.8 Tf  [(Larissa Arning)] TJ ET
0.271 0.267 0.267 rg
BT 26.250 627.533 Td /F1 9.8 Tf  [(Saft C, Wieczorek S, Landwehrmeyer GB, Roos RA, de Yebenes JG, Dose M, Tabrizi SJ, Craufurd D, the European )] TJ ET
BT 26.250 615.628 Td /F1 9.8 Tf  [(Huntington's Disease Network tRio, Arning L. NMDA receptor gene variations as modifiers in Huntington disease: a replication )] TJ ET
BT 26.250 603.723 Td /F1 9.8 Tf  [(study. PLOS Currents Huntington Disease. 2011 Jul 11 . Edition 1. doi: 10.1371/currents.RRN1247.)] TJ ET
q
15.000 29.878 577.500 571.465 re W n
0.271 0.267 0.267 rg
BT 26.250 574.621 Td /F4 12.0 Tf  [(Abstract)] TJ ET
BT 26.250 554.667 Td /F1 9.8 Tf  [(Several candidate modifier genes which, in addition to the pathogenic CAG repeat expansion, influence the age at onset \(AO\) in )] TJ ET
BT 26.250 542.762 Td /F1 9.8 Tf  [(Huntington disease \(HD\) have already been described. The aim of this study was to replicate association of variations in the N-)] TJ ET
BT 26.250 530.857 Td /F1 9.8 Tf  [(methyl D-aspartate receptor subtype genes GRIN2A and GRIN2B in the �REGISTRY� cohort from the European Huntington )] TJ ET
BT 26.250 518.952 Td /F1 9.8 Tf  [(Disease Network \(EHDN\). The analyses did replicate the association reported between the GRIN2A rs2650427 variation and )] TJ ET
BT 26.250 507.048 Td /F1 9.8 Tf  [(AO in the entire cohort. Yet, when subjects were stratified by AO subtypes, we found nominally significant evidence for an )] TJ ET
BT 26.250 495.143 Td /F1 9.8 Tf  [(association of the GRIN2A rs1969060 variation and the GRIN2B rs1806201 variation. These findings further implicate the N-)] TJ ET
BT 26.250 483.238 Td /F1 9.8 Tf  [(methyl D-aspartate receptor subtype genes as loci containing variation associated with AO in HD.)] TJ ET
BT 26.250 446.636 Td /F4 12.0 Tf  [(Introduction)] TJ ET
BT 26.250 426.681 Td /F1 9.8 Tf  [(Huntington disease \(HD\) is an autosomal dominant neurodegenerative disorder characterised by motor disturbances, cognitive )] TJ ET
BT 26.250 414.777 Td /F1 9.8 Tf  [(decline, and neuropsychiatric symptoms. It is caused by a CAG repeat expansion \(>36 repeats\) in exon 1 of the )] TJ ET
BT 509.918 414.777 Td /F5 9.8 Tf  [(HTT)] TJ ET
BT 528.872 414.777 Td /F1 9.8 Tf  [( gene. )] TJ ET
0.267 0.267 0.267 rg
BT 558.688 414.777 Td /F1 9.8 Tf  [([1])] TJ ET
0.271 0.267 0.267 rg
BT 26.250 402.872 Td /F1 9.8 Tf  [(The lengths of the expanded CAG tract is inversely related to the age at clinical onset of HD, accounting for more than half of )] TJ ET
BT 26.250 390.967 Td /F1 9.8 Tf  [(the overall variance in age at onset \(AO\). )] TJ ET
0.267 0.267 0.267 rg
BT 206.167 390.967 Td /F1 9.8 Tf  [([2])] TJ ET
0.271 0.267 0.267 rg
BT 217.009 390.967 Td /F1 9.8 Tf  [( Despite this strong correlation, there remains considerable variation of over 40 )] TJ ET
BT 26.250 379.062 Td /F1 9.8 Tf  [(years in AO in individuals with identical repeat lengths. Several candidate modifier genes of HD have already been described in )] TJ ET
BT 26.250 367.158 Td /F1 9.8 Tf  [(independent studies. )] TJ ET
0.267 0.267 0.267 rg
BT 118.933 367.158 Td /F1 9.8 Tf  [([3] [4] [5] [6] [7] [8] [9])] TJ ET
0.271 0.267 0.267 rg
BT 211.090 367.158 Td /F1 9.8 Tf  [( In order to confirm the associations between modifier gene variations and AO, )] TJ ET
BT 26.250 355.253 Td /F1 9.8 Tf  [(independent replication studies are compulsory. Here, we tested the primary hypothesis of an original study )] TJ ET
0.267 0.267 0.267 rg
BT 491.744 355.253 Td /F1 9.8 Tf  [([4])] TJ ET
0.271 0.267 0.267 rg
BT 502.586 355.253 Td /F1 9.8 Tf  [( , that variations )] TJ ET
BT 26.250 343.348 Td /F1 9.8 Tf  [(in the NR2A and NR2B glutamate receptor subunit genes \( )] TJ ET
BT 282.577 343.348 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 318.877 343.348 Td /F1 9.8 Tf  [( , )] TJ ET
BT 327.008 343.348 Td /F5 9.8 Tf  [(GRIN2B)] TJ ET
BT 363.308 343.348 Td /F1 9.8 Tf  [( \) explain additional variance in AO for HD.)] TJ ET
BT 26.250 306.746 Td /F4 12.0 Tf  [(Methods)] TJ ET
BT 26.250 286.791 Td /F1 9.8 Tf  [(The study cohort comprised 1,211 individuals of European ancestry with HD collected by the EHDN �REGISTRY� study prior to )] TJ ET
BT 26.250 274.887 Td /F1 9.8 Tf  [(October 14, 2008. �REGISTRY� is a multi-centre, multi-national observational study which aims to obtain natural history data on )] TJ ET
BT 26.250 262.982 Td /F1 9.8 Tf  [(a wide spectrum of the European HD population \(https://www.euro-hd.net/html/registry\). )] TJ ET
0.267 0.267 0.267 rg
BT 402.317 262.982 Td /F1 9.8 Tf  [([10])] TJ ET
0.271 0.267 0.267 rg
BT 418.580 262.982 Td /F1 9.8 Tf  [( In order to test previously reported )] TJ ET
BT 26.250 251.077 Td /F1 9.8 Tf  [(HD genetic modifiers in this cohort, HD patients with available data on age, sex, age at symptom onset, mutant CAG repeat size )] TJ ET
BT 26.250 239.172 Td /F1 9.8 Tf  [(and body mass index \(BMI\) were included \(initial )] TJ ET
BT 238.654 239.172 Td /F5 9.8 Tf  [(n)] TJ ET
BT 244.075 239.172 Td /F1 9.8 Tf  [( = 1211; )] TJ ET
BT 282.295 239.172 Td /F5 9.8 Tf  [(n)] TJ ET
BT 287.716 239.172 Td /F1 9.8 Tf  [( = 1069; 529 men and 540 women had a complete data set\).)] TJ ET
BT 26.250 219.768 Td /F1 9.8 Tf  [(The expanded trinucleotide repeats ranged from 40 to 89 with a mean \(� SD\) of 45�4.7 CAGs, and AO ranged from 6 to 74 )] TJ ET
BT 26.250 207.863 Td /F1 9.8 Tf  [(years, with an onset \(mean � SD\) of 42 �11.8 years. AO was defined as the age at which, according to the rater, the first signs )] TJ ET
BT 26.250 195.958 Td /F1 9.8 Tf  [(of HD appeared. Five hundred and thirty-eight patients first presented with motor disturbances \(mean � SD motor AO = )] TJ ET
BT 26.250 184.053 Td /F1 9.8 Tf  [(43.4�11.6 years\), 241 with psychiatric problems \(mean � SD psychiatric AO = 39.9�10.8 years\), and 112 with cognitive decline )] TJ ET
BT 26.250 172.149 Td /F1 9.8 Tf  [(\(mean � SD cognitive AO = 38.6�13.1 years\). For the remaining patients no specific symptoms were listed \(mean � SD AO = )] TJ ET
BT 26.250 160.244 Td /F1 9.8 Tf  [(42.1�11.8 years\). Genotyping of three SNPs was conducted as described before. )] TJ ET
0.267 0.267 0.267 rg
BT 379.873 160.244 Td /F1 9.8 Tf  [([4])] TJ ET
0.271 0.267 0.267 rg
BT 26.250 123.641 Td /F4 12.0 Tf  [(Results)] TJ ET
BT 26.250 103.687 Td /F1 9.8 Tf  [(None of the SNPs deviated from Hardy )] TJ ET
BT 197.489 103.687 Td /F5 9.8 Tf  [(�)] TJ ET
BT 202.910 103.687 Td /F1 9.8 Tf  [( Weinberg Equilibrium \(HWE\). Considering the earliest AO \( )] TJ ET
BT 463.518 103.687 Td /F5 9.8 Tf  [(n)] TJ ET
BT 468.939 103.687 Td /F1 9.8 Tf  [( = 1,069\), we did find )] TJ ET
BT 26.250 91.782 Td /F1 9.8 Tf  [(evidence of association of the )] TJ ET
BT 157.407 91.782 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 193.706 91.782 Td /F1 9.8 Tf  [( SNP rs2650427 \(table 1\). The R )] TJ ET
BT 338.396 95.671 Td /F1 8.7 Tf  [(2)] TJ ET
BT 343.215 91.782 Td /F1 9.8 Tf  [( statistic rose modestly \(from 0.634 to 0.635\) but )] TJ ET
BT 26.250 79.878 Td /F1 9.8 Tf  [(significantly \(p=0.028\) when )] TJ ET
BT 150.075 79.878 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 186.374 79.878 Td /F1 9.8 Tf  [( genotypes were added to the regression model. The analysis did not, however, replicate )] TJ ET
BT 26.250 67.973 Td /F1 9.8 Tf  [(the association reported between the SNP rs1969060 in intron 2 of the )] TJ ET
BT 333.005 67.973 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 369.304 67.973 Td /F1 9.8 Tf  [( gene and SNP C2664T \(rs1806201\) in exon 12 )] TJ ET
BT 26.250 56.068 Td /F1 9.8 Tf  [(of the )] TJ ET
BT 53.355 56.068 Td /F5 9.8 Tf  [(GRIN2B)] TJ ET
BT 89.654 56.068 Td /F1 9.8 Tf  [( gene \(table 1\); but when dividing the cohort according to the nature of the symptoms presented initially, both the )] TJ ET
BT 26.250 44.163 Td /F5 9.8 Tf  [(GRIN2B)] TJ ET
BT 62.549 44.163 Td /F1 9.8 Tf  [( C2664T and the )] TJ ET
BT 137.887 44.163 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 174.187 44.163 Td /F1 9.8 Tf  [( rs1969060 polymorphisms explained a small but considerable amount of additional variance )] TJ ET
Q
q
15.000 684.354 577.500 53.646 re W n
0.267 0.267 0.267 rg
BT 15.000 718.042 Td /F2 21.0 Tf  [(NMDA receptor gene variations as modifiers in Huntington )] TJ ET
BT 15.000 693.094 Td /F2 21.0 Tf  [(disease: a replication study)] TJ ET
Q
0.271 0.267 0.267 rg
BT 15.000 675.088 Td /F3 9.8 Tf  [(July 11, 2011)] TJ ET
BT 72.681 675.088 Td /F3 9.8 Tf  [(�)] TJ ET
0.267 0.267 0.267 rg
BT 77.556 675.088 Td /F3 9.8 Tf  [(Genetics)] TJ ET
BT 26.250 663.247 Td /F1 9.8 Tf  [(Carsten Saft)] TJ ET
0.271 0.267 0.267 rg
BT 80.441 663.247 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 85.862 663.247 Td /F1 9.8 Tf  [(jorgtepplen)] TJ ET
0.271 0.267 0.267 rg
BT 134.095 663.247 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 139.516 663.247 Td /F1 9.8 Tf  [(Stefan Wieczorek)] TJ ET
0.271 0.267 0.267 rg
BT 215.917 663.247 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 221.338 663.247 Td /F1 9.8 Tf  [(G. Bernhard Landwehrmeyer)] TJ ET
0.271 0.267 0.267 rg
BT 347.054 663.247 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 352.475 663.247 Td /F1 9.8 Tf  [(Raymund A.C. Roos)] TJ ET
0.271 0.267 0.267 rg
BT 441.337 663.247 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 446.758 663.247 Td /F1 9.8 Tf  [(Justo Garcia de Yebenes)] TJ ET
0.271 0.267 0.267 rg
BT 556.231 663.247 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 26.250 651.342 Td /F1 9.8 Tf  [(Matthias Dose)] TJ ET
0.271 0.267 0.267 rg
BT 88.562 651.342 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 93.983 651.342 Td /F1 9.8 Tf  [(Sarah J Tabrizi)] TJ ET
0.271 0.267 0.267 rg
BT 159.542 651.342 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 164.963 651.342 Td /F1 9.8 Tf  [(David Craufurd)] TJ ET
0.271 0.267 0.267 rg
BT 230.522 651.342 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 235.943 651.342 Td /F1 9.8 Tf  [(the REGISTRY investigators of the European Huntington's Disease Network)] TJ ET
0.271 0.267 0.267 rg
BT 564.567 651.342 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 26.250 639.438 Td /F1 9.8 Tf  [(Larissa Arning)] TJ ET
0.271 0.267 0.267 rg
BT 26.250 627.533 Td /F1 9.8 Tf  [(Saft C, Wieczorek S, Landwehrmeyer GB, Roos RA, de Yebenes JG, Dose M, Tabrizi SJ, Craufurd D, the European )] TJ ET
BT 26.250 615.628 Td /F1 9.8 Tf  [(Huntington's Disease Network tRio, Arning L. NMDA receptor gene variations as modifiers in Huntington disease: a replication )] TJ ET
BT 26.250 603.723 Td /F1 9.8 Tf  [(study. PLOS Currents Huntington Disease. 2011 Jul 11 . Edition 1. doi: 10.1371/currents.RRN1247.)] TJ ET
q
15.000 29.878 577.500 571.465 re W n
0.271 0.267 0.267 rg
BT 26.250 574.621 Td /F4 12.0 Tf  [(Abstract)] TJ ET
BT 26.250 554.667 Td /F1 9.8 Tf  [(Several candidate modifier genes which, in addition to the pathogenic CAG repeat expansion, influence the age at onset \(AO\) in )] TJ ET
BT 26.250 542.762 Td /F1 9.8 Tf  [(Huntington disease \(HD\) have already been described. The aim of this study was to replicate association of variations in the N-)] TJ ET
BT 26.250 530.857 Td /F1 9.8 Tf  [(methyl D-aspartate receptor subtype genes GRIN2A and GRIN2B in the �REGISTRY� cohort from the European Huntington )] TJ ET
BT 26.250 518.952 Td /F1 9.8 Tf  [(Disease Network \(EHDN\). The analyses did replicate the association reported between the GRIN2A rs2650427 variation and )] TJ ET
BT 26.250 507.048 Td /F1 9.8 Tf  [(AO in the entire cohort. Yet, when subjects were stratified by AO subtypes, we found nominally significant evidence for an )] TJ ET
BT 26.250 495.143 Td /F1 9.8 Tf  [(association of the GRIN2A rs1969060 variation and the GRIN2B rs1806201 variation. These findings further implicate the N-)] TJ ET
BT 26.250 483.238 Td /F1 9.8 Tf  [(methyl D-aspartate receptor subtype genes as loci containing variation associated with AO in HD.)] TJ ET
BT 26.250 446.636 Td /F4 12.0 Tf  [(Introduction)] TJ ET
BT 26.250 426.681 Td /F1 9.8 Tf  [(Huntington disease \(HD\) is an autosomal dominant neurodegenerative disorder characterised by motor disturbances, cognitive )] TJ ET
BT 26.250 414.777 Td /F1 9.8 Tf  [(decline, and neuropsychiatric symptoms. It is caused by a CAG repeat expansion \(>36 repeats\) in exon 1 of the )] TJ ET
BT 509.918 414.777 Td /F5 9.8 Tf  [(HTT)] TJ ET
BT 528.872 414.777 Td /F1 9.8 Tf  [( gene. )] TJ ET
0.267 0.267 0.267 rg
BT 558.688 414.777 Td /F1 9.8 Tf  [([1])] TJ ET
0.271 0.267 0.267 rg
BT 26.250 402.872 Td /F1 9.8 Tf  [(The lengths of the expanded CAG tract is inversely related to the age at clinical onset of HD, accounting for more than half of )] TJ ET
BT 26.250 390.967 Td /F1 9.8 Tf  [(the overall variance in age at onset \(AO\). )] TJ ET
0.267 0.267 0.267 rg
BT 206.167 390.967 Td /F1 9.8 Tf  [([2])] TJ ET
0.271 0.267 0.267 rg
BT 217.009 390.967 Td /F1 9.8 Tf  [( Despite this strong correlation, there remains considerable variation of over 40 )] TJ ET
BT 26.250 379.062 Td /F1 9.8 Tf  [(years in AO in individuals with identical repeat lengths. Several candidate modifier genes of HD have already been described in )] TJ ET
BT 26.250 367.158 Td /F1 9.8 Tf  [(independent studies. )] TJ ET
0.267 0.267 0.267 rg
BT 118.933 367.158 Td /F1 9.8 Tf  [([3] [4] [5] [6] [7] [8] [9])] TJ ET
0.271 0.267 0.267 rg
BT 211.090 367.158 Td /F1 9.8 Tf  [( In order to confirm the associations between modifier gene variations and AO, )] TJ ET
BT 26.250 355.253 Td /F1 9.8 Tf  [(independent replication studies are compulsory. Here, we tested the primary hypothesis of an original study )] TJ ET
0.267 0.267 0.267 rg
BT 491.744 355.253 Td /F1 9.8 Tf  [([4])] TJ ET
0.271 0.267 0.267 rg
BT 502.586 355.253 Td /F1 9.8 Tf  [( , that variations )] TJ ET
BT 26.250 343.348 Td /F1 9.8 Tf  [(in the NR2A and NR2B glutamate receptor subunit genes \( )] TJ ET
BT 282.577 343.348 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 318.877 343.348 Td /F1 9.8 Tf  [( , )] TJ ET
BT 327.008 343.348 Td /F5 9.8 Tf  [(GRIN2B)] TJ ET
BT 363.308 343.348 Td /F1 9.8 Tf  [( \) explain additional variance in AO for HD.)] TJ ET
BT 26.250 306.746 Td /F4 12.0 Tf  [(Methods)] TJ ET
BT 26.250 286.791 Td /F1 9.8 Tf  [(The study cohort comprised 1,211 individuals of European ancestry with HD collected by the EHDN �REGISTRY� study prior to )] TJ ET
BT 26.250 274.887 Td /F1 9.8 Tf  [(October 14, 2008. �REGISTRY� is a multi-centre, multi-national observational study which aims to obtain natural history data on )] TJ ET
BT 26.250 262.982 Td /F1 9.8 Tf  [(a wide spectrum of the European HD population \(https://www.euro-hd.net/html/registry\). )] TJ ET
0.267 0.267 0.267 rg
BT 402.317 262.982 Td /F1 9.8 Tf  [([10])] TJ ET
0.271 0.267 0.267 rg
BT 418.580 262.982 Td /F1 9.8 Tf  [( In order to test previously reported )] TJ ET
BT 26.250 251.077 Td /F1 9.8 Tf  [(HD genetic modifiers in this cohort, HD patients with available data on age, sex, age at symptom onset, mutant CAG repeat size )] TJ ET
BT 26.250 239.172 Td /F1 9.8 Tf  [(and body mass index \(BMI\) were included \(initial )] TJ ET
BT 238.654 239.172 Td /F5 9.8 Tf  [(n)] TJ ET
BT 244.075 239.172 Td /F1 9.8 Tf  [( = 1211; )] TJ ET
BT 282.295 239.172 Td /F5 9.8 Tf  [(n)] TJ ET
BT 287.716 239.172 Td /F1 9.8 Tf  [( = 1069; 529 men and 540 women had a complete data set\).)] TJ ET
BT 26.250 219.768 Td /F1 9.8 Tf  [(The expanded trinucleotide repeats ranged from 40 to 89 with a mean \(� SD\) of 45�4.7 CAGs, and AO ranged from 6 to 74 )] TJ ET
BT 26.250 207.863 Td /F1 9.8 Tf  [(years, with an onset \(mean � SD\) of 42 �11.8 years. AO was defined as the age at which, according to the rater, the first signs )] TJ ET
BT 26.250 195.958 Td /F1 9.8 Tf  [(of HD appeared. Five hundred and thirty-eight patients first presented with motor disturbances \(mean � SD motor AO = )] TJ ET
BT 26.250 184.053 Td /F1 9.8 Tf  [(43.4�11.6 years\), 241 with psychiatric problems \(mean � SD psychiatric AO = 39.9�10.8 years\), and 112 with cognitive decline )] TJ ET
BT 26.250 172.149 Td /F1 9.8 Tf  [(\(mean � SD cognitive AO = 38.6�13.1 years\). For the remaining patients no specific symptoms were listed \(mean � SD AO = )] TJ ET
BT 26.250 160.244 Td /F1 9.8 Tf  [(42.1�11.8 years\). Genotyping of three SNPs was conducted as described before. )] TJ ET
0.267 0.267 0.267 rg
BT 379.873 160.244 Td /F1 9.8 Tf  [([4])] TJ ET
0.271 0.267 0.267 rg
BT 26.250 123.641 Td /F4 12.0 Tf  [(Results)] TJ ET
BT 26.250 103.687 Td /F1 9.8 Tf  [(None of the SNPs deviated from Hardy )] TJ ET
BT 197.489 103.687 Td /F5 9.8 Tf  [(�)] TJ ET
BT 202.910 103.687 Td /F1 9.8 Tf  [( Weinberg Equilibrium \(HWE\). Considering the earliest AO \( )] TJ ET
BT 463.518 103.687 Td /F5 9.8 Tf  [(n)] TJ ET
BT 468.939 103.687 Td /F1 9.8 Tf  [( = 1,069\), we did find )] TJ ET
BT 26.250 91.782 Td /F1 9.8 Tf  [(evidence of association of the )] TJ ET
BT 157.407 91.782 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 193.706 91.782 Td /F1 9.8 Tf  [( SNP rs2650427 \(table 1\). The R )] TJ ET
BT 338.396 95.671 Td /F1 8.7 Tf  [(2)] TJ ET
BT 343.215 91.782 Td /F1 9.8 Tf  [( statistic rose modestly \(from 0.634 to 0.635\) but )] TJ ET
BT 26.250 79.878 Td /F1 9.8 Tf  [(significantly \(p=0.028\) when )] TJ ET
BT 150.075 79.878 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 186.374 79.878 Td /F1 9.8 Tf  [( genotypes were added to the regression model. The analysis did not, however, replicate )] TJ ET
BT 26.250 67.973 Td /F1 9.8 Tf  [(the association reported between the SNP rs1969060 in intron 2 of the )] TJ ET
BT 333.005 67.973 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 369.304 67.973 Td /F1 9.8 Tf  [( gene and SNP C2664T \(rs1806201\) in exon 12 )] TJ ET
BT 26.250 56.068 Td /F1 9.8 Tf  [(of the )] TJ ET
BT 53.355 56.068 Td /F5 9.8 Tf  [(GRIN2B)] TJ ET
BT 89.654 56.068 Td /F1 9.8 Tf  [( gene \(table 1\); but when dividing the cohort according to the nature of the symptoms presented initially, both the )] TJ ET
BT 26.250 44.163 Td /F5 9.8 Tf  [(GRIN2B)] TJ ET
BT 62.549 44.163 Td /F1 9.8 Tf  [( C2664T and the )] TJ ET
BT 137.887 44.163 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 174.187 44.163 Td /F1 9.8 Tf  [( rs1969060 polymorphisms explained a small but considerable amount of additional variance )] TJ ET
Q
q
15.000 684.354 577.500 53.646 re W n
0.267 0.267 0.267 rg
BT 15.000 718.042 Td /F2 21.0 Tf  [(NMDA receptor gene variations as modifiers in Huntington )] TJ ET
BT 15.000 693.094 Td /F2 21.0 Tf  [(disease: a replication study)] TJ ET
Q
0.271 0.267 0.267 rg
BT 15.000 675.088 Td /F3 9.8 Tf  [(July 11, 2011)] TJ ET
BT 72.681 675.088 Td /F3 9.8 Tf  [(�)] TJ ET
0.267 0.267 0.267 rg
BT 77.556 675.088 Td /F3 9.8 Tf  [(Genetics)] TJ ET
BT 26.250 663.247 Td /F1 9.8 Tf  [(Carsten Saft)] TJ ET
0.271 0.267 0.267 rg
BT 80.441 663.247 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 85.862 663.247 Td /F1 9.8 Tf  [(jorgtepplen)] TJ ET
0.271 0.267 0.267 rg
BT 134.095 663.247 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 139.516 663.247 Td /F1 9.8 Tf  [(Stefan Wieczorek)] TJ ET
0.271 0.267 0.267 rg
BT 215.917 663.247 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 221.338 663.247 Td /F1 9.8 Tf  [(G. Bernhard Landwehrmeyer)] TJ ET
0.271 0.267 0.267 rg
BT 347.054 663.247 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 352.475 663.247 Td /F1 9.8 Tf  [(Raymund A.C. Roos)] TJ ET
0.271 0.267 0.267 rg
BT 441.337 663.247 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 446.758 663.247 Td /F1 9.8 Tf  [(Justo Garcia de Yebenes)] TJ ET
0.271 0.267 0.267 rg
BT 556.231 663.247 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 26.250 651.342 Td /F1 9.8 Tf  [(Matthias Dose)] TJ ET
0.271 0.267 0.267 rg
BT 88.562 651.342 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 93.983 651.342 Td /F1 9.8 Tf  [(Sarah J Tabrizi)] TJ ET
0.271 0.267 0.267 rg
BT 159.542 651.342 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 164.963 651.342 Td /F1 9.8 Tf  [(David Craufurd)] TJ ET
0.271 0.267 0.267 rg
BT 230.522 651.342 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 235.943 651.342 Td /F1 9.8 Tf  [(the REGISTRY investigators of the European Huntington's Disease Network)] TJ ET
0.271 0.267 0.267 rg
BT 564.567 651.342 Td /F1 9.8 Tf  [(, )] TJ ET
0.267 0.267 0.267 rg
BT 26.250 639.438 Td /F1 9.8 Tf  [(Larissa Arning)] TJ ET
0.271 0.267 0.267 rg
BT 26.250 627.533 Td /F1 9.8 Tf  [(Saft C, Wieczorek S, Landwehrmeyer GB, Roos RA, de Yebenes JG, Dose M, Tabrizi SJ, Craufurd D, the European )] TJ ET
BT 26.250 615.628 Td /F1 9.8 Tf  [(Huntington's Disease Network tRio, Arning L. NMDA receptor gene variations as modifiers in Huntington disease: a replication )] TJ ET
BT 26.250 603.723 Td /F1 9.8 Tf  [(study. PLOS Currents Huntington Disease. 2011 Jul 11 . Edition 1. doi: 10.1371/currents.RRN1247.)] TJ ET
q
15.000 29.878 577.500 571.465 re W n
0.271 0.267 0.267 rg
BT 26.250 574.621 Td /F4 12.0 Tf  [(Abstract)] TJ ET
BT 26.250 554.667 Td /F1 9.8 Tf  [(Several candidate modifier genes which, in addition to the pathogenic CAG repeat expansion, influence the age at onset \(AO\) in )] TJ ET
BT 26.250 542.762 Td /F1 9.8 Tf  [(Huntington disease \(HD\) have already been described. The aim of this study was to replicate association of variations in the N-)] TJ ET
BT 26.250 530.857 Td /F1 9.8 Tf  [(methyl D-aspartate receptor subtype genes GRIN2A and GRIN2B in the �REGISTRY� cohort from the European Huntington )] TJ ET
BT 26.250 518.952 Td /F1 9.8 Tf  [(Disease Network \(EHDN\). The analyses did replicate the association reported between the GRIN2A rs2650427 variation and )] TJ ET
BT 26.250 507.048 Td /F1 9.8 Tf  [(AO in the entire cohort. Yet, when subjects were stratified by AO subtypes, we found nominally significant evidence for an )] TJ ET
BT 26.250 495.143 Td /F1 9.8 Tf  [(association of the GRIN2A rs1969060 variation and the GRIN2B rs1806201 variation. These findings further implicate the N-)] TJ ET
BT 26.250 483.238 Td /F1 9.8 Tf  [(methyl D-aspartate receptor subtype genes as loci containing variation associated with AO in HD.)] TJ ET
BT 26.250 446.636 Td /F4 12.0 Tf  [(Introduction)] TJ ET
BT 26.250 426.681 Td /F1 9.8 Tf  [(Huntington disease \(HD\) is an autosomal dominant neurodegenerative disorder characterised by motor disturbances, cognitive )] TJ ET
BT 26.250 414.777 Td /F1 9.8 Tf  [(decline, and neuropsychiatric symptoms. It is caused by a CAG repeat expansion \(>36 repeats\) in exon 1 of the )] TJ ET
BT 509.918 414.777 Td /F5 9.8 Tf  [(HTT)] TJ ET
BT 528.872 414.777 Td /F1 9.8 Tf  [( gene. )] TJ ET
0.267 0.267 0.267 rg
BT 558.688 414.777 Td /F1 9.8 Tf  [([1])] TJ ET
0.271 0.267 0.267 rg
BT 26.250 402.872 Td /F1 9.8 Tf  [(The lengths of the expanded CAG tract is inversely related to the age at clinical onset of HD, accounting for more than half of )] TJ ET
BT 26.250 390.967 Td /F1 9.8 Tf  [(the overall variance in age at onset \(AO\). )] TJ ET
0.267 0.267 0.267 rg
BT 206.167 390.967 Td /F1 9.8 Tf  [([2])] TJ ET
0.271 0.267 0.267 rg
BT 217.009 390.967 Td /F1 9.8 Tf  [( Despite this strong correlation, there remains considerable variation of over 40 )] TJ ET
BT 26.250 379.062 Td /F1 9.8 Tf  [(years in AO in individuals with identical repeat lengths. Several candidate modifier genes of HD have already been described in )] TJ ET
BT 26.250 367.158 Td /F1 9.8 Tf  [(independent studies. )] TJ ET
0.267 0.267 0.267 rg
BT 118.933 367.158 Td /F1 9.8 Tf  [([3] [4] [5] [6] [7] [8] [9])] TJ ET
0.271 0.267 0.267 rg
BT 211.090 367.158 Td /F1 9.8 Tf  [( In order to confirm the associations between modifier gene variations and AO, )] TJ ET
BT 26.250 355.253 Td /F1 9.8 Tf  [(independent replication studies are compulsory. Here, we tested the primary hypothesis of an original study )] TJ ET
0.267 0.267 0.267 rg
BT 491.744 355.253 Td /F1 9.8 Tf  [([4])] TJ ET
0.271 0.267 0.267 rg
BT 502.586 355.253 Td /F1 9.8 Tf  [( , that variations )] TJ ET
BT 26.250 343.348 Td /F1 9.8 Tf  [(in the NR2A and NR2B glutamate receptor subunit genes \( )] TJ ET
BT 282.577 343.348 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 318.877 343.348 Td /F1 9.8 Tf  [( , )] TJ ET
BT 327.008 343.348 Td /F5 9.8 Tf  [(GRIN2B)] TJ ET
BT 363.308 343.348 Td /F1 9.8 Tf  [( \) explain additional variance in AO for HD.)] TJ ET
BT 26.250 306.746 Td /F4 12.0 Tf  [(Methods)] TJ ET
BT 26.250 286.791 Td /F1 9.8 Tf  [(The study cohort comprised 1,211 individuals of European ancestry with HD collected by the EHDN �REGISTRY� study prior to )] TJ ET
BT 26.250 274.887 Td /F1 9.8 Tf  [(October 14, 2008. �REGISTRY� is a multi-centre, multi-national observational study which aims to obtain natural history data on )] TJ ET
BT 26.250 262.982 Td /F1 9.8 Tf  [(a wide spectrum of the European HD population \(https://www.euro-hd.net/html/registry\). )] TJ ET
0.267 0.267 0.267 rg
BT 402.317 262.982 Td /F1 9.8 Tf  [([10])] TJ ET
0.271 0.267 0.267 rg
BT 418.580 262.982 Td /F1 9.8 Tf  [( In order to test previously reported )] TJ ET
BT 26.250 251.077 Td /F1 9.8 Tf  [(HD genetic modifiers in this cohort, HD patients with available data on age, sex, age at symptom onset, mutant CAG repeat size )] TJ ET
BT 26.250 239.172 Td /F1 9.8 Tf  [(and body mass index \(BMI\) were included \(initial )] TJ ET
BT 238.654 239.172 Td /F5 9.8 Tf  [(n)] TJ ET
BT 244.075 239.172 Td /F1 9.8 Tf  [( = 1211; )] TJ ET
BT 282.295 239.172 Td /F5 9.8 Tf  [(n)] TJ ET
BT 287.716 239.172 Td /F1 9.8 Tf  [( = 1069; 529 men and 540 women had a complete data set\).)] TJ ET
BT 26.250 219.768 Td /F1 9.8 Tf  [(The expanded trinucleotide repeats ranged from 40 to 89 with a mean \(� SD\) of 45�4.7 CAGs, and AO ranged from 6 to 74 )] TJ ET
BT 26.250 207.863 Td /F1 9.8 Tf  [(years, with an onset \(mean � SD\) of 42 �11.8 years. AO was defined as the age at which, according to the rater, the first signs )] TJ ET
BT 26.250 195.958 Td /F1 9.8 Tf  [(of HD appeared. Five hundred and thirty-eight patients first presented with motor disturbances \(mean � SD motor AO = )] TJ ET
BT 26.250 184.053 Td /F1 9.8 Tf  [(43.4�11.6 years\), 241 with psychiatric problems \(mean � SD psychiatric AO = 39.9�10.8 years\), and 112 with cognitive decline )] TJ ET
BT 26.250 172.149 Td /F1 9.8 Tf  [(\(mean � SD cognitive AO = 38.6�13.1 years\). For the remaining patients no specific symptoms were listed \(mean � SD AO = )] TJ ET
BT 26.250 160.244 Td /F1 9.8 Tf  [(42.1�11.8 years\). Genotyping of three SNPs was conducted as described before. )] TJ ET
0.267 0.267 0.267 rg
BT 379.873 160.244 Td /F1 9.8 Tf  [([4])] TJ ET
0.271 0.267 0.267 rg
BT 26.250 123.641 Td /F4 12.0 Tf  [(Results)] TJ ET
BT 26.250 103.687 Td /F1 9.8 Tf  [(None of the SNPs deviated from Hardy )] TJ ET
BT 197.489 103.687 Td /F5 9.8 Tf  [(�)] TJ ET
BT 202.910 103.687 Td /F1 9.8 Tf  [( Weinberg Equilibrium \(HWE\). Considering the earliest AO \( )] TJ ET
BT 463.518 103.687 Td /F5 9.8 Tf  [(n)] TJ ET
BT 468.939 103.687 Td /F1 9.8 Tf  [( = 1,069\), we did find )] TJ ET
BT 26.250 91.782 Td /F1 9.8 Tf  [(evidence of association of the )] TJ ET
BT 157.407 91.782 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 193.706 91.782 Td /F1 9.8 Tf  [( SNP rs2650427 \(table 1\). The R )] TJ ET
BT 338.396 95.671 Td /F1 8.7 Tf  [(2)] TJ ET
BT 343.215 91.782 Td /F1 9.8 Tf  [( statistic rose modestly \(from 0.634 to 0.635\) but )] TJ ET
BT 26.250 79.878 Td /F1 9.8 Tf  [(significantly \(p=0.028\) when )] TJ ET
BT 150.075 79.878 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 186.374 79.878 Td /F1 9.8 Tf  [( genotypes were added to the regression model. The analysis did not, however, replicate )] TJ ET
BT 26.250 67.973 Td /F1 9.8 Tf  [(the association reported between the SNP rs1969060 in intron 2 of the )] TJ ET
BT 333.005 67.973 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 369.304 67.973 Td /F1 9.8 Tf  [( gene and SNP C2664T \(rs1806201\) in exon 12 )] TJ ET
BT 26.250 56.068 Td /F1 9.8 Tf  [(of the )] TJ ET
BT 53.355 56.068 Td /F5 9.8 Tf  [(GRIN2B)] TJ ET
BT 89.654 56.068 Td /F1 9.8 Tf  [( gene \(table 1\); but when dividing the cohort according to the nature of the symptoms presented initially, both the )] TJ ET
BT 26.250 44.163 Td /F5 9.8 Tf  [(GRIN2B)] TJ ET
BT 62.549 44.163 Td /F1 9.8 Tf  [( C2664T and the )] TJ ET
BT 137.887 44.163 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 174.187 44.163 Td /F1 9.8 Tf  [( rs1969060 polymorphisms explained a small but considerable amount of additional variance )] TJ ET
Q
q
0.000 0.000 0.000 rg
BT 291.710 19.825 Td /F1 11.0 Tf  [(1)] TJ ET
BT 25.000 19.825 Td /F1 11.0 Tf  [(PLOS Currents Huntington Disease)] TJ ET

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stream

0.271 0.267 0.267 rg
q
15.000 79.059 577.500 697.941 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(in residual AO in the respective samples. Inclusion of the )] TJ ET
BT 273.900 767.476 Td /F5 9.8 Tf  [(GRIN2B)] TJ ET
BT 310.199 767.476 Td /F1 9.8 Tf  [( genotypes in the model for motor AO \( )] TJ ET
BT 480.902 767.476 Td /F5 9.8 Tf  [(n)] TJ ET
BT 486.323 767.476 Td /F1 9.8 Tf  [( = 538\) increased the )] TJ ET
BT 26.250 755.571 Td /F1 9.8 Tf  [(R )] TJ ET
BT 36.000 759.460 Td /F1 8.7 Tf  [(2)] TJ ET
BT 40.819 755.571 Td /F1 9.8 Tf  [( statistic from 0.620 to 0.623 \(p=0.046\) and in the study of 241 patients with psychiatric AO, the R )] TJ ET
BT 463.267 759.460 Td /F1 8.7 Tf  [(2)] TJ ET
BT 468.085 755.571 Td /F1 9.8 Tf  [( statistic of the )] TJ ET
BT 26.250 743.667 Td /F1 9.8 Tf  [(exponential regression rose from 0.515 to 0.523 with the )] TJ ET
BT 272.291 743.667 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 308.591 743.667 Td /F1 9.8 Tf  [( rs1969060 genotypes included \(p=0.026, table 1\). )] TJ ET
BT 26.250 731.762 Td /F1 9.8 Tf  [(Interestingly, the association of cognitive AO \( )] TJ ET
BT 226.759 731.762 Td /F5 9.8 Tf  [(n)] TJ ET
BT 232.180 731.762 Td /F1 9.8 Tf  [( = 112\) with the )] TJ ET
BT 301.824 731.762 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 338.123 731.762 Td /F1 9.8 Tf  [( rs2650427 polymorphism shows the highest nominal )] TJ ET
BT 26.250 719.857 Td /F1 9.8 Tf  [(significance as compared to the other models in the study \(0.770 to 0.775, p=0.014\). Yet, the results remain )] TJ ET
BT 26.250 707.952 Td /F1 9.8 Tf  [(statisticallysignificant when excluding the patients with CAGs over >70 \(n=4\).)] TJ ET
1.000 1.000 1.000 rg
26.250 79.059 555.000 619.013 re f
0.753 0.753 0.753 rg
27.000 673.809 131.804 23.512 re f
0.267 0.267 0.267 rg
26.625 696.947 132.554 0.750 re f
26.625 673.434 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 31.875 687.091 Td /F1 9.8 Tf  [(Model)] TJ ET
0.753 0.753 0.753 rg
158.804 673.809 85.436 23.512 re f
0.267 0.267 0.267 rg
158.429 696.947 86.186 0.750 re f
158.429 673.434 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 163.679 687.091 Td /F1 9.8 Tf  [(Genotypes)] TJ ET
0.753 0.753 0.753 rg
244.240 673.809 96.563 23.512 re f
0.267 0.267 0.267 rg
243.865 696.947 97.313 0.750 re f
243.865 673.434 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 249.115 687.091 Td /F1 9.8 Tf  [(CAGmean � SD)] TJ ET
0.753 0.753 0.753 rg
340.803 673.809 122.786 23.512 re f
0.267 0.267 0.267 rg
340.428 696.947 123.536 0.750 re f
340.428 673.434 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 345.678 687.091 Td /F4 9.8 Tf  [(erliest AO)] TJ ET
BT 345.678 679.460 Td /F1 9.8 Tf  [(mean � SD)] TJ ET
0.753 0.753 0.753 rg
463.589 673.809 50.273 23.512 re f
0.267 0.267 0.267 rg
463.214 696.947 51.023 0.750 re f
463.214 673.434 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 468.464 687.091 Td /F1 9.8 Tf  [(R�*)] TJ ET
0.753 0.753 0.753 rg
513.862 673.809 66.638 23.512 re f
0.267 0.267 0.267 rg
513.487 696.947 67.388 0.750 re f
513.487 673.434 0.750 24.262 re f
580.125 673.434 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 518.737 687.091 Td /F1 9.8 Tf  [(P value)] TJ ET
0.600 0.600 0.600 rg
27.000 657.928 131.804 15.881 re f
0.267 0.267 0.267 rg
26.625 673.434 132.554 0.750 re f
26.625 657.553 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 663.579 Td /F1 9.8 Tf  [(HD CAG 40-89 \( )] TJ ET
BT 106.102 663.579 Td /F5 9.8 Tf  [(n)] TJ ET
BT 111.523 663.579 Td /F1 9.8 Tf  [( =1069\))] TJ ET
0.600 0.600 0.600 rg
158.804 657.928 85.436 15.881 re f
0.267 0.267 0.267 rg
158.429 673.434 86.186 0.750 re f
158.429 657.553 0.750 16.631 re f
0.600 0.600 0.600 rg
244.240 657.928 96.563 15.881 re f
0.267 0.267 0.267 rg
243.865 673.434 97.313 0.750 re f
243.865 657.553 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 663.579 Td /F1 9.8 Tf  [(44.97�4.7)] TJ ET
0.600 0.600 0.600 rg
340.803 657.928 122.786 15.881 re f
0.267 0.267 0.267 rg
340.428 673.434 123.536 0.750 re f
340.428 657.553 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 663.579 Td /F1 9.8 Tf  [(41.87�11.8)] TJ ET
0.600 0.600 0.600 rg
463.589 657.928 50.273 15.881 re f
0.267 0.267 0.267 rg
463.214 673.434 51.023 0.750 re f
463.214 657.553 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 663.579 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.600 0.600 0.600 rg
513.862 657.928 66.638 15.881 re f
0.267 0.267 0.267 rg
513.487 673.434 67.388 0.750 re f
513.487 657.553 0.750 16.631 re f
580.125 657.553 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 663.579 Td /F1 9.8 Tf  [(<0.0005)] TJ ET
0.267 0.267 0.267 rg
26.625 657.553 132.554 0.750 re f
26.625 634.040 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 31.875 647.698 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 647.698 Td /F5 9.8 Tf  [(GRIN2B)] TJ ET
BT 76.579 647.698 Td /F1 9.8 Tf  [( C2664T )] TJ ET
BT 31.875 640.067 Td /F1 9.8 Tf  [(\(rs1806201\))] TJ ET
0.267 0.267 0.267 rg
158.429 657.553 86.186 0.750 re f
158.429 634.040 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 163.679 647.698 Td /F1 9.8 Tf  [(CC \(n=560\))] TJ ET
0.267 0.267 0.267 rg
243.865 657.553 97.313 0.750 re f
243.865 634.040 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 249.115 647.698 Td /F1 9.8 Tf  [(44.94�4.8)] TJ ET
0.267 0.267 0.267 rg
340.428 657.553 123.536 0.750 re f
340.428 634.040 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 345.678 647.698 Td /F1 9.8 Tf  [(42.13�12.1)] TJ ET
0.267 0.267 0.267 rg
463.214 657.553 51.023 0.750 re f
463.214 634.040 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 468.464 647.698 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 657.553 67.388 0.750 re f
513.487 634.040 0.750 24.262 re f
580.125 634.040 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 518.737 647.698 Td /F1 9.8 Tf  [(0.541)] TJ ET
0.267 0.267 0.267 rg
26.625 634.040 132.554 0.750 re f
26.625 618.159 0.750 16.631 re f
158.429 634.040 86.186 0.750 re f
158.429 618.159 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 624.185 Td /F1 9.8 Tf  [(CT \(n=436\))] TJ ET
0.267 0.267 0.267 rg
243.865 634.040 97.313 0.750 re f
243.865 618.159 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 624.185 Td /F1 9.8 Tf  [(45.02�4.5)] TJ ET
0.267 0.267 0.267 rg
340.428 634.040 123.536 0.750 re f
340.428 618.159 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 624.185 Td /F1 9.8 Tf  [(41.32�11.3)] TJ ET
0.267 0.267 0.267 rg
463.214 634.040 51.023 0.750 re f
463.214 618.159 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 624.185 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 634.040 67.388 0.750 re f
513.487 618.159 0.750 16.631 re f
580.125 618.159 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 624.185 Td /F1 9.8 Tf  [(0.199)] TJ ET
0.267 0.267 0.267 rg
26.625 618.159 132.554 0.750 re f
26.625 602.278 0.750 16.631 re f
158.429 618.159 86.186 0.750 re f
158.429 602.278 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 608.304 Td /F1 9.8 Tf  [(TT \(n=73\))] TJ ET
0.267 0.267 0.267 rg
243.865 618.159 97.313 0.750 re f
243.865 602.278 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 608.304 Td /F1 9.8 Tf  [(44.86�4.6)] TJ ET
0.267 0.267 0.267 rg
340.428 618.159 123.536 0.750 re f
340.428 602.278 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 608.304 Td /F1 9.8 Tf  [(43.14�11.9)] TJ ET
0.267 0.267 0.267 rg
463.214 618.159 51.023 0.750 re f
463.214 602.278 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 608.304 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 618.159 67.388 0.750 re f
513.487 602.278 0.750 16.631 re f
580.125 602.278 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 608.304 Td /F1 9.8 Tf  [(0.196)] TJ ET
0.267 0.267 0.267 rg
26.625 602.278 132.554 0.750 re f
26.625 586.396 0.750 16.631 re f
158.429 602.278 86.186 0.750 re f
158.429 586.396 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 592.423 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 602.278 97.313 0.750 re f
243.865 586.396 0.750 16.631 re f
340.428 602.278 123.536 0.750 re f
340.428 586.396 0.750 16.631 re f
463.214 602.278 51.023 0.750 re f
463.214 586.396 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 592.423 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 602.278 67.388 0.750 re f
513.487 586.396 0.750 16.631 re f
580.125 586.396 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 592.423 Td /F1 9.8 Tf  [(0.973)] TJ ET
0.267 0.267 0.267 rg
26.625 586.397 132.554 0.750 re f
26.625 570.515 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 576.542 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 576.542 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 76.579 576.542 Td /F1 9.8 Tf  [( rs1969060)] TJ ET
0.267 0.267 0.267 rg
158.429 586.397 86.186 0.750 re f
158.429 570.515 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 576.542 Td /F1 9.8 Tf  [(TT \(n=745\))] TJ ET
0.267 0.267 0.267 rg
243.865 586.397 97.313 0.750 re f
243.865 570.515 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 576.542 Td /F1 9.8 Tf  [(44.83�4.5)] TJ ET
0.267 0.267 0.267 rg
340.428 586.397 123.536 0.750 re f
340.428 570.515 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 576.542 Td /F1 9.8 Tf  [(42.00�11.9)] TJ ET
0.267 0.267 0.267 rg
463.214 586.397 51.023 0.750 re f
463.214 570.515 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 576.542 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 586.397 67.388 0.750 re f
513.487 570.515 0.750 16.631 re f
580.125 570.515 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 576.542 Td /F1 9.8 Tf  [(0.160)] TJ ET
0.267 0.267 0.267 rg
26.625 570.515 132.554 0.750 re f
26.625 554.634 0.750 16.631 re f
158.429 570.515 86.186 0.750 re f
158.429 554.634 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 560.660 Td /F1 9.8 Tf  [(TC \(n=292\))] TJ ET
0.267 0.267 0.267 rg
243.865 570.515 97.313 0.750 re f
243.865 554.634 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 560.660 Td /F1 9.8 Tf  [(45.24�5.1)] TJ ET
0.267 0.267 0.267 rg
340.428 570.515 123.536 0.750 re f
340.428 554.634 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 560.660 Td /F1 9.8 Tf  [(41.67�11.5)] TJ ET
0.267 0.267 0.267 rg
463.214 570.515 51.023 0.750 re f
463.214 554.634 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 560.660 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 570.515 67.388 0.750 re f
513.487 554.634 0.750 16.631 re f
580.125 554.634 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 560.660 Td /F1 9.8 Tf  [(0.203)] TJ ET
0.267 0.267 0.267 rg
26.625 554.634 132.554 0.750 re f
26.625 538.753 0.750 16.631 re f
158.429 554.634 86.186 0.750 re f
158.429 538.753 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 544.779 Td /F1 9.8 Tf  [(CC \(n=32\))] TJ ET
0.267 0.267 0.267 rg
243.865 554.634 97.313 0.750 re f
243.865 538.753 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 544.779 Td /F1 9.8 Tf  [(45.75�4.2)] TJ ET
0.267 0.267 0.267 rg
340.428 554.634 123.536 0.750 re f
340.428 538.753 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 544.779 Td /F1 9.8 Tf  [(40.66�11.5)] TJ ET
0.267 0.267 0.267 rg
463.214 554.634 51.023 0.750 re f
463.214 538.753 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 544.779 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 554.634 67.388 0.750 re f
513.487 538.753 0.750 16.631 re f
580.125 538.753 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 544.779 Td /F1 9.8 Tf  [(0.645)] TJ ET
0.267 0.267 0.267 rg
26.625 538.753 132.554 0.750 re f
26.625 522.872 0.750 16.631 re f
158.429 538.753 86.186 0.750 re f
158.429 522.872 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 528.898 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 538.753 97.313 0.750 re f
243.865 522.872 0.750 16.631 re f
340.428 538.753 123.536 0.750 re f
340.428 522.872 0.750 16.631 re f
463.214 538.753 51.023 0.750 re f
463.214 522.872 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 528.898 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 538.753 67.388 0.750 re f
513.487 522.872 0.750 16.631 re f
580.125 522.872 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 528.898 Td /F1 9.8 Tf  [(0.172)] TJ ET
0.267 0.267 0.267 rg
26.625 522.872 132.554 0.750 re f
26.625 506.990 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 513.017 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 513.017 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 76.579 513.017 Td /F1 9.8 Tf  [( rs2650427)] TJ ET
0.267 0.267 0.267 rg
158.429 522.872 86.186 0.750 re f
158.429 506.990 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 513.017 Td /F1 9.8 Tf  [(CC \(n=374\))] TJ ET
0.267 0.267 0.267 rg
243.865 522.872 97.313 0.750 re f
243.865 506.990 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 513.017 Td /F1 9.8 Tf  [(44.99�4.0)] TJ ET
0.267 0.267 0.267 rg
340.428 522.872 123.536 0.750 re f
340.428 506.990 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 513.017 Td /F1 9.8 Tf  [(41.40�11.9)] TJ ET
0.267 0.267 0.267 rg
463.214 522.872 51.023 0.750 re f
463.214 506.990 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 513.017 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 522.872 67.388 0.750 re f
513.487 506.990 0.750 16.631 re f
580.125 506.990 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 513.017 Td /F1 9.8 Tf  [(0.125)] TJ ET
0.267 0.267 0.267 rg
26.625 506.990 132.554 0.750 re f
26.625 491.109 0.750 16.631 re f
158.429 506.990 86.186 0.750 re f
158.429 491.109 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 497.135 Td /F1 9.8 Tf  [(CT \(n=512\))] TJ ET
0.267 0.267 0.267 rg
243.865 506.990 97.313 0.750 re f
243.865 491.109 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 497.135 Td /F1 9.8 Tf  [(44.94�5.2)] TJ ET
0.267 0.267 0.267 rg
340.428 506.990 123.536 0.750 re f
340.428 491.109 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 497.135 Td /F1 9.8 Tf  [(41.99�11.9)] TJ ET
0.267 0.267 0.267 rg
463.214 506.990 51.023 0.750 re f
463.214 491.109 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 497.135 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 506.990 67.388 0.750 re f
513.487 491.109 0.750 16.631 re f
580.125 491.109 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 497.135 Td /F1 9.8 Tf  [(0.891)] TJ ET
0.267 0.267 0.267 rg
26.625 491.109 132.554 0.750 re f
26.625 475.228 0.750 16.631 re f
158.429 491.109 86.186 0.750 re f
158.429 475.228 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 481.254 Td /F1 9.8 Tf  [(TT \(n=183\))] TJ ET
0.267 0.267 0.267 rg
243.865 491.109 97.313 0.750 re f
243.865 475.228 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 481.254 Td /F1 9.8 Tf  [(42.51�4.2)] TJ ET
0.267 0.267 0.267 rg
340.428 491.109 123.536 0.750 re f
340.428 475.228 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 481.254 Td /F1 9.8 Tf  [(43.14�10.9)] TJ ET
0.267 0.267 0.267 rg
463.214 491.109 51.023 0.750 re f
463.214 475.228 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 481.254 Td /F4 9.8 Tf  [(0.635)] TJ ET
0.267 0.267 0.267 rg
513.487 491.109 67.388 0.750 re f
513.487 475.228 0.750 16.631 re f
580.125 475.228 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 481.254 Td /F4 9.8 Tf  [(0.031)] TJ ET
0.267 0.267 0.267 rg
26.625 475.228 132.554 0.750 re f
26.625 459.346 0.750 16.631 re f
158.429 475.228 86.186 0.750 re f
158.429 459.346 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 465.373 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 475.228 97.313 0.750 re f
243.865 459.346 0.750 16.631 re f
340.428 475.228 123.536 0.750 re f
340.428 459.346 0.750 16.631 re f
463.214 475.228 51.023 0.750 re f
463.214 459.346 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 465.373 Td /F4 9.8 Tf  [(0.635)] TJ ET
0.267 0.267 0.267 rg
513.487 475.228 67.388 0.750 re f
513.487 459.346 0.750 16.631 re f
580.125 459.346 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 465.373 Td /F4 9.8 Tf  [(0.028)] TJ ET
0.753 0.753 0.753 rg
27.000 436.209 131.804 23.512 re f
0.267 0.267 0.267 rg
26.625 459.346 132.554 0.750 re f
26.625 435.834 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 31.875 449.491 Td /F1 9.8 Tf  [(Model)] TJ ET
0.753 0.753 0.753 rg
158.804 436.209 85.436 23.512 re f
0.267 0.267 0.267 rg
158.429 459.346 86.186 0.750 re f
158.429 435.834 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 163.679 449.491 Td /F1 9.8 Tf  [(Genotypes)] TJ ET
0.753 0.753 0.753 rg
244.240 436.209 96.563 23.512 re f
0.267 0.267 0.267 rg
243.865 459.346 97.313 0.750 re f
243.865 435.834 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 249.115 449.491 Td /F1 9.8 Tf  [(CAGmean � SD)] TJ ET
0.753 0.753 0.753 rg
340.803 436.209 122.786 23.512 re f
0.267 0.267 0.267 rg
340.428 459.346 123.536 0.750 re f
340.428 435.834 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 345.678 449.491 Td /F4 9.8 Tf  [(motor AO)] TJ ET
BT 345.678 441.860 Td /F1 9.8 Tf  [(mean � SD)] TJ ET
0.753 0.753 0.753 rg
463.589 436.209 50.273 23.512 re f
0.267 0.267 0.267 rg
463.214 459.346 51.023 0.750 re f
463.214 435.834 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 468.464 449.491 Td /F1 9.8 Tf  [(R�*)] TJ ET
0.753 0.753 0.753 rg
513.862 436.209 66.638 23.512 re f
0.267 0.267 0.267 rg
513.487 459.346 67.388 0.750 re f
513.487 435.834 0.750 24.262 re f
580.125 435.834 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 518.737 449.491 Td /F1 9.8 Tf  [(P value)] TJ ET
0.600 0.600 0.600 rg
27.000 420.328 131.804 15.881 re f
0.267 0.267 0.267 rg
26.625 435.834 132.554 0.750 re f
26.625 419.953 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 425.979 Td /F1 9.8 Tf  [(HD CAG 40-77 \( )] TJ ET
BT 106.102 425.979 Td /F5 9.8 Tf  [(n)] TJ ET
BT 111.523 425.979 Td /F1 9.8 Tf  [( =538\))] TJ ET
0.600 0.600 0.600 rg
158.804 420.328 85.436 15.881 re f
0.267 0.267 0.267 rg
158.429 435.834 86.186 0.750 re f
158.429 419.953 0.750 16.631 re f
0.600 0.600 0.600 rg
244.240 420.328 96.563 15.881 re f
0.267 0.267 0.267 rg
243.865 435.834 97.313 0.750 re f
243.865 419.953 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 425.979 Td /F1 9.8 Tf  [(44.72�4.0)] TJ ET
0.600 0.600 0.600 rg
340.803 420.328 122.786 15.881 re f
0.267 0.267 0.267 rg
340.428 435.834 123.536 0.750 re f
340.428 419.953 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 425.979 Td /F4 9.8 Tf  [(43.39�11.6)] TJ ET
0.600 0.600 0.600 rg
463.589 420.328 50.273 15.881 re f
0.267 0.267 0.267 rg
463.214 435.834 51.023 0.750 re f
463.214 419.953 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 425.979 Td /F1 9.8 Tf  [(0.620)] TJ ET
0.600 0.600 0.600 rg
513.862 420.328 66.638 15.881 re f
0.267 0.267 0.267 rg
513.487 435.834 67.388 0.750 re f
513.487 419.953 0.750 16.631 re f
580.125 419.953 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 425.979 Td /F1 9.8 Tf  [(<0.0005)] TJ ET
0.267 0.267 0.267 rg
26.625 419.953 132.554 0.750 re f
26.625 396.440 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 31.875 410.098 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 410.098 Td /F5 9.8 Tf  [(GRIN2B)] TJ ET
BT 76.579 410.098 Td /F1 9.8 Tf  [( C2664T )] TJ ET
BT 31.875 402.466 Td /F1 9.8 Tf  [(\(rs1806201\))] TJ ET
0.267 0.267 0.267 rg
158.429 419.953 86.186 0.750 re f
158.429 396.440 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 163.679 410.098 Td /F1 9.8 Tf  [(CC \(n=274\))] TJ ET
0.267 0.267 0.267 rg
243.865 419.953 97.313 0.750 re f
243.865 396.440 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 249.115 410.098 Td /F1 9.8 Tf  [(44.52�3.8)] TJ ET
0.267 0.267 0.267 rg
340.428 419.953 123.536 0.750 re f
340.428 396.440 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 345.678 410.098 Td /F1 9.8 Tf  [(44.41�11.8)] TJ ET
0.267 0.267 0.267 rg
463.214 419.953 51.023 0.750 re f
463.214 396.440 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 468.464 410.098 Td /F1 9.8 Tf  [(0.622)] TJ ET
0.267 0.267 0.267 rg
513.487 419.953 67.388 0.750 re f
513.487 396.440 0.750 24.262 re f
580.125 396.440 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 518.737 410.098 Td /F1 9.8 Tf  [(0.099)] TJ ET
0.267 0.267 0.267 rg
26.625 396.440 132.554 0.750 re f
26.625 380.559 0.750 16.631 re f
158.429 396.440 86.186 0.750 re f
158.429 380.559 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 386.585 Td /F1 9.8 Tf  [(CT \(n=221\))] TJ ET
0.267 0.267 0.267 rg
243.865 396.440 97.313 0.750 re f
243.865 380.559 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 386.585 Td /F1 9.8 Tf  [(44.96�4.1)] TJ ET
0.267 0.267 0.267 rg
340.428 396.440 123.536 0.750 re f
340.428 380.559 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 386.585 Td /F1 9.8 Tf  [(41.98�11.1)] TJ ET
0.267 0.267 0.267 rg
463.214 396.440 51.023 0.750 re f
463.214 380.559 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 386.585 Td /F4 9.8 Tf  [(0.623)] TJ ET
0.267 0.267 0.267 rg
513.487 396.440 67.388 0.750 re f
513.487 380.559 0.750 16.631 re f
580.125 380.559 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 386.585 Td /F4 9.8 Tf  [(0.046)] TJ ET
0.267 0.267 0.267 rg
26.625 380.559 132.554 0.750 re f
26.625 364.678 0.750 16.631 re f
158.429 380.559 86.186 0.750 re f
158.429 364.678 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 370.704 Td /F1 9.8 Tf  [(TT \(n=43\))] TJ ET
0.267 0.267 0.267 rg
243.865 380.559 97.313 0.750 re f
243.865 364.678 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 370.704 Td /F1 9.8 Tf  [(44.77�4.9)] TJ ET
0.267 0.267 0.267 rg
340.428 380.559 123.536 0.750 re f
340.428 364.678 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 370.704 Td /F1 9.8 Tf  [(44.07�12.4)] TJ ET
0.267 0.267 0.267 rg
463.214 380.559 51.023 0.750 re f
463.214 364.678 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 370.704 Td /F1 9.8 Tf  [(0.620)] TJ ET
0.267 0.267 0.267 rg
513.487 380.559 67.388 0.750 re f
513.487 364.678 0.750 16.631 re f
580.125 364.678 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 370.704 Td /F1 9.8 Tf  [(0.560)] TJ ET
0.267 0.267 0.267 rg
26.625 364.678 132.554 0.750 re f
26.625 348.797 0.750 16.631 re f
158.429 364.678 86.186 0.750 re f
158.429 348.797 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 354.823 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 364.678 97.313 0.750 re f
243.865 348.797 0.750 16.631 re f
340.428 364.678 123.536 0.750 re f
340.428 348.797 0.750 16.631 re f
463.214 364.678 51.023 0.750 re f
463.214 348.797 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 354.823 Td /F1 9.8 Tf  [(0.621)] TJ ET
0.267 0.267 0.267 rg
513.487 364.678 67.388 0.750 re f
513.487 348.797 0.750 16.631 re f
580.125 348.797 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 354.823 Td /F1 9.8 Tf  [(0.296)] TJ ET
0.267 0.267 0.267 rg
26.625 348.797 132.554 0.750 re f
26.625 332.915 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 338.942 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 338.942 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 76.579 338.942 Td /F1 9.8 Tf  [( rs1969060)] TJ ET
0.267 0.267 0.267 rg
158.429 348.797 86.186 0.750 re f
158.429 332.915 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 338.942 Td /F1 9.8 Tf  [(TT \(n=373\))] TJ ET
0.267 0.267 0.267 rg
243.865 348.797 97.313 0.750 re f
243.865 332.915 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 338.942 Td /F1 9.8 Tf  [(44.51�3.6)] TJ ET
0.267 0.267 0.267 rg
340.428 348.797 123.536 0.750 re f
340.428 332.915 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 338.942 Td /F1 9.8 Tf  [(43.79�11.5)] TJ ET
0.267 0.267 0.267 rg
463.214 348.797 51.023 0.750 re f
463.214 332.915 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 338.942 Td /F1 9.8 Tf  [(0.620)] TJ ET
0.267 0.267 0.267 rg
513.487 348.797 67.388 0.750 re f
513.487 332.915 0.750 16.631 re f
580.125 332.915 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 338.942 Td /F1 9.8 Tf  [(0.824)] TJ ET
0.267 0.267 0.267 rg
26.625 332.915 132.554 0.750 re f
26.625 317.034 0.750 16.631 re f
158.429 332.915 86.186 0.750 re f
158.429 317.034 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 323.060 Td /F1 9.8 Tf  [(TC \(n=153\))] TJ ET
0.267 0.267 0.267 rg
243.865 332.915 97.313 0.750 re f
243.865 317.034 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 323.060 Td /F1 9.8 Tf  [(45.32�4.9)] TJ ET
0.267 0.267 0.267 rg
340.428 332.915 123.536 0.750 re f
340.428 317.034 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 323.060 Td /F1 9.8 Tf  [(42.19�11.9)] TJ ET
0.267 0.267 0.267 rg
463.214 332.915 51.023 0.750 re f
463.214 317.034 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 323.060 Td /F1 9.8 Tf  [(0.620)] TJ ET
0.267 0.267 0.267 rg
513.487 332.915 67.388 0.750 re f
513.487 317.034 0.750 16.631 re f
580.125 317.034 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 323.060 Td /F1 9.8 Tf  [(0.934)] TJ ET
0.267 0.267 0.267 rg
26.625 317.034 132.554 0.750 re f
26.625 301.153 0.750 16.631 re f
158.429 317.034 86.186 0.750 re f
158.429 301.153 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 307.179 Td /F1 9.8 Tf  [(CC \(n=12\))] TJ ET
0.267 0.267 0.267 rg
243.865 317.034 97.313 0.750 re f
243.865 301.153 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 307.179 Td /F1 9.8 Tf  [(43.75�2.5)] TJ ET
0.267 0.267 0.267 rg
340.428 317.034 123.536 0.750 re f
340.428 301.153 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 307.179 Td /F1 9.8 Tf  [(46.25�9.5)] TJ ET
0.267 0.267 0.267 rg
463.214 317.034 51.023 0.750 re f
463.214 301.153 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 307.179 Td /F1 9.8 Tf  [(0.620)] TJ ET
0.267 0.267 0.267 rg
513.487 317.034 67.388 0.750 re f
513.487 301.153 0.750 16.631 re f
580.125 301.153 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 307.179 Td /F1 9.8 Tf  [(0.658)] TJ ET
0.267 0.267 0.267 rg
26.625 301.153 132.554 0.750 re f
26.625 285.271 0.750 16.631 re f
158.429 301.153 86.186 0.750 re f
158.429 285.271 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 291.298 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 301.153 97.313 0.750 re f
243.865 285.271 0.750 16.631 re f
340.428 301.153 123.536 0.750 re f
340.428 285.271 0.750 16.631 re f
463.214 301.153 51.023 0.750 re f
463.214 285.271 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 291.298 Td /F1 9.8 Tf  [(0.620)] TJ ET
0.267 0.267 0.267 rg
513.487 301.153 67.388 0.750 re f
513.487 285.271 0.750 16.631 re f
580.125 285.271 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 291.298 Td /F1 9.8 Tf  [(0.744)] TJ ET
0.267 0.267 0.267 rg
26.625 285.271 132.554 0.750 re f
26.625 269.390 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 275.416 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 275.416 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 76.579 275.416 Td /F1 9.8 Tf  [( rs2650427)] TJ ET
0.267 0.267 0.267 rg
158.429 285.271 86.186 0.750 re f
158.429 269.390 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 275.416 Td /F1 9.8 Tf  [(CC \(n=181\))] TJ ET
0.267 0.267 0.267 rg
243.865 285.271 97.313 0.750 re f
243.865 269.390 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 275.416 Td /F1 9.8 Tf  [(44.15�3.8)] TJ ET
0.267 0.267 0.267 rg
340.428 285.271 123.536 0.750 re f
340.428 269.390 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 275.416 Td /F1 9.8 Tf  [(41.99�11.8)] TJ ET
0.267 0.267 0.267 rg
463.214 285.271 51.023 0.750 re f
463.214 269.390 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 275.416 Td /F1 9.8 Tf  [(0.620)] TJ ET
0.267 0.267 0.267 rg
513.487 285.271 67.388 0.750 re f
513.487 269.390 0.750 16.631 re f
580.125 269.390 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 275.416 Td /F1 9.8 Tf  [(0.362)] TJ ET
0.267 0.267 0.267 rg
26.625 269.390 132.554 0.750 re f
26.625 253.509 0.750 16.631 re f
158.429 269.390 86.186 0.750 re f
158.429 253.509 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 259.535 Td /F1 9.8 Tf  [(CT \(n=259\))] TJ ET
0.267 0.267 0.267 rg
243.865 269.390 97.313 0.750 re f
243.865 253.509 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 259.535 Td /F1 9.8 Tf  [(44.48�4.1)] TJ ET
0.267 0.267 0.267 rg
340.428 269.390 123.536 0.750 re f
340.428 253.509 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 259.535 Td /F1 9.8 Tf  [(44.00�11.9)] TJ ET
0.267 0.267 0.267 rg
463.214 269.390 51.023 0.750 re f
463.214 253.509 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 259.535 Td /F1 9.8 Tf  [(0.620)] TJ ET
0.267 0.267 0.267 rg
513.487 269.390 67.388 0.750 re f
513.487 253.509 0.750 16.631 re f
580.125 253.509 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 259.535 Td /F1 9.8 Tf  [(0.792)] TJ ET
0.267 0.267 0.267 rg
26.625 253.509 132.554 0.750 re f
26.625 237.628 0.750 16.631 re f
158.429 253.509 86.186 0.750 re f
158.429 237.628 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 243.654 Td /F1 9.8 Tf  [(TT \(n=98\))] TJ ET
0.267 0.267 0.267 rg
243.865 253.509 97.313 0.750 re f
243.865 237.628 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 243.654 Td /F1 9.8 Tf  [(44.60�4.2)] TJ ET
0.267 0.267 0.267 rg
340.428 253.509 123.536 0.750 re f
340.428 237.628 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 243.654 Td /F1 9.8 Tf  [(44.34�10.4)] TJ ET
0.267 0.267 0.267 rg
463.214 253.509 51.023 0.750 re f
463.214 237.628 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 243.654 Td /F1 9.8 Tf  [(0.621)] TJ ET
0.267 0.267 0.267 rg
513.487 253.509 67.388 0.750 re f
513.487 237.628 0.750 16.631 re f
580.125 237.628 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 243.654 Td /F1 9.8 Tf  [(0.143)] TJ ET
0.267 0.267 0.267 rg
26.625 237.628 132.554 0.750 re f
26.625 221.746 0.750 16.631 re f
158.429 237.628 86.186 0.750 re f
158.429 221.746 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 227.773 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 237.628 97.313 0.750 re f
243.865 221.746 0.750 16.631 re f
340.428 237.628 123.536 0.750 re f
340.428 221.746 0.750 16.631 re f
463.214 237.628 51.023 0.750 re f
463.214 221.746 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 227.773 Td /F1 9.8 Tf  [(0.621)] TJ ET
0.267 0.267 0.267 rg
513.487 237.628 67.388 0.750 re f
513.487 221.746 0.750 16.631 re f
580.125 221.746 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 227.773 Td /F1 9.8 Tf  [(0.158)] TJ ET
0.753 0.753 0.753 rg
27.000 198.609 131.804 23.512 re f
0.267 0.267 0.267 rg
26.625 221.746 132.554 0.750 re f
26.625 198.234 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 31.875 211.891 Td /F1 9.8 Tf  [(Model)] TJ ET
0.753 0.753 0.753 rg
158.804 198.609 85.436 23.512 re f
0.267 0.267 0.267 rg
158.429 221.746 86.186 0.750 re f
158.429 198.234 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 163.679 211.891 Td /F1 9.8 Tf  [(Genotypes)] TJ ET
0.753 0.753 0.753 rg
244.240 198.609 96.563 23.512 re f
0.267 0.267 0.267 rg
243.865 221.746 97.313 0.750 re f
243.865 198.234 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 249.115 211.891 Td /F1 9.8 Tf  [(CAGmean � SD)] TJ ET
0.753 0.753 0.753 rg
340.803 198.609 122.786 23.512 re f
0.267 0.267 0.267 rg
340.428 221.746 123.536 0.750 re f
340.428 198.234 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 345.678 211.891 Td /F4 9.8 Tf  [(psychiatric AO)] TJ ET
BT 414.493 211.891 Td /F1 9.8 Tf  [(mean � )] TJ ET
BT 345.678 204.260 Td /F1 9.8 Tf  [(SD)] TJ ET
0.753 0.753 0.753 rg
463.589 198.609 50.273 23.512 re f
0.267 0.267 0.267 rg
463.214 221.746 51.023 0.750 re f
463.214 198.234 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 468.464 211.891 Td /F1 9.8 Tf  [(R�*)] TJ ET
0.753 0.753 0.753 rg
513.862 198.609 66.638 23.512 re f
0.267 0.267 0.267 rg
513.487 221.746 67.388 0.750 re f
513.487 198.234 0.750 24.262 re f
580.125 198.234 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 518.737 211.891 Td /F1 9.8 Tf  [(P value)] TJ ET
0.600 0.600 0.600 rg
27.000 182.728 131.804 15.881 re f
0.267 0.267 0.267 rg
26.625 198.234 132.554 0.750 re f
26.625 182.353 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 188.379 Td /F1 9.8 Tf  [(HD CAG 40-67 \( )] TJ ET
BT 106.102 188.379 Td /F5 9.8 Tf  [(n)] TJ ET
BT 111.523 188.379 Td /F1 9.8 Tf  [( =241\))] TJ ET
0.600 0.600 0.600 rg
158.804 182.728 85.436 15.881 re f
0.267 0.267 0.267 rg
158.429 198.234 86.186 0.750 re f
158.429 182.353 0.750 16.631 re f
0.600 0.600 0.600 rg
244.240 182.728 96.563 15.881 re f
0.267 0.267 0.267 rg
243.865 198.234 97.313 0.750 re f
243.865 182.353 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 188.379 Td /F1 9.8 Tf  [(44.73�4.1)] TJ ET
0.600 0.600 0.600 rg
340.803 182.728 122.786 15.881 re f
0.267 0.267 0.267 rg
340.428 198.234 123.536 0.750 re f
340.428 182.353 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 188.379 Td /F4 9.8 Tf  [(39.86�10.8)] TJ ET
0.600 0.600 0.600 rg
463.589 182.728 50.273 15.881 re f
0.267 0.267 0.267 rg
463.214 198.234 51.023 0.750 re f
463.214 182.353 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 188.379 Td /F1 9.8 Tf  [(0.515)] TJ ET
0.600 0.600 0.600 rg
513.862 182.728 66.638 15.881 re f
0.267 0.267 0.267 rg
513.487 198.234 67.388 0.750 re f
513.487 182.353 0.750 16.631 re f
580.125 182.353 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 188.379 Td /F1 9.8 Tf  [(<0.0005)] TJ ET
0.267 0.267 0.267 rg
26.625 182.353 132.554 0.750 re f
26.625 158.840 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 31.875 172.498 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 172.498 Td /F5 9.8 Tf  [(GRIN2B)] TJ ET
BT 76.579 172.498 Td /F1 9.8 Tf  [( C2664T )] TJ ET
BT 31.875 164.866 Td /F1 9.8 Tf  [(\(rs1806201\))] TJ ET
0.267 0.267 0.267 rg
158.429 182.353 86.186 0.750 re f
158.429 158.840 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 163.679 172.498 Td /F1 9.8 Tf  [(CC \(n=139\))] TJ ET
0.267 0.267 0.267 rg
243.865 182.353 97.313 0.750 re f
243.865 158.840 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 249.115 172.498 Td /F1 9.8 Tf  [(44.81�4.4)] TJ ET
0.267 0.267 0.267 rg
340.428 182.353 123.536 0.750 re f
340.428 158.840 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 345.678 172.498 Td /F1 9.8 Tf  [(39.50�11.3)] TJ ET
0.267 0.267 0.267 rg
463.214 182.353 51.023 0.750 re f
463.214 158.840 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 468.464 172.498 Td /F1 9.8 Tf  [(0.513)] TJ ET
0.267 0.267 0.267 rg
513.487 182.353 67.388 0.750 re f
513.487 158.840 0.750 24.262 re f
580.125 158.840 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 518.737 172.498 Td /F1 9.8 Tf  [(0.964)] TJ ET
0.267 0.267 0.267 rg
26.625 158.840 132.554 0.750 re f
26.625 142.959 0.750 16.631 re f
158.429 158.840 86.186 0.750 re f
158.429 142.959 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 148.985 Td /F1 9.8 Tf  [(CT \(n=90\))] TJ ET
0.267 0.267 0.267 rg
243.865 158.840 97.313 0.750 re f
243.865 142.959 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 148.985 Td /F1 9.8 Tf  [(44.74�3.8)] TJ ET
0.267 0.267 0.267 rg
340.428 158.840 123.536 0.750 re f
340.428 142.959 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 148.985 Td /F1 9.8 Tf  [(39.79�10.5)] TJ ET
0.267 0.267 0.267 rg
463.214 158.840 51.023 0.750 re f
463.214 142.959 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 148.985 Td /F1 9.8 Tf  [(0.514)] TJ ET
0.267 0.267 0.267 rg
513.487 158.840 67.388 0.750 re f
513.487 142.959 0.750 16.631 re f
580.125 142.959 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 148.985 Td /F1 9.8 Tf  [(0.607)] TJ ET
0.267 0.267 0.267 rg
26.625 142.959 132.554 0.750 re f
26.625 127.078 0.750 16.631 re f
158.429 142.959 86.186 0.750 re f
158.429 127.078 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 133.104 Td /F1 9.8 Tf  [(TT \(n=12\))] TJ ET
0.267 0.267 0.267 rg
243.865 142.959 97.313 0.750 re f
243.865 127.078 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 133.104 Td /F1 9.8 Tf  [(43.67�2.1)] TJ ET
0.267 0.267 0.267 rg
340.428 142.959 123.536 0.750 re f
340.428 127.078 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 133.104 Td /F1 9.8 Tf  [(44.58�9.6)] TJ ET
0.267 0.267 0.267 rg
463.214 142.959 51.023 0.750 re f
463.214 127.078 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 133.104 Td /F1 9.8 Tf  [(0.517)] TJ ET
0.267 0.267 0.267 rg
513.487 142.959 67.388 0.750 re f
513.487 127.078 0.750 16.631 re f
580.125 127.078 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 133.104 Td /F1 9.8 Tf  [(0.211)] TJ ET
0.267 0.267 0.267 rg
26.625 127.078 132.554 0.750 re f
26.625 111.196 0.750 16.631 re f
158.429 127.078 86.186 0.750 re f
158.429 111.196 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 117.223 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 127.078 97.313 0.750 re f
243.865 111.196 0.750 16.631 re f
340.428 127.078 123.536 0.750 re f
340.428 111.196 0.750 16.631 re f
463.214 127.078 51.023 0.750 re f
463.214 111.196 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 117.223 Td /F1 9.8 Tf  [(0.514)] TJ ET
0.267 0.267 0.267 rg
513.487 127.078 67.388 0.750 re f
513.487 111.196 0.750 16.631 re f
580.125 111.196 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 117.223 Td /F1 9.8 Tf  [(0.618)] TJ ET
0.267 0.267 0.267 rg
26.625 111.196 132.554 0.750 re f
26.625 95.315 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 101.341 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 101.341 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 76.579 101.341 Td /F1 9.8 Tf  [( rs1969060)] TJ ET
0.267 0.267 0.267 rg
158.429 111.196 86.186 0.750 re f
158.429 95.315 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 101.341 Td /F1 9.8 Tf  [(TT \(n=172\))] TJ ET
0.267 0.267 0.267 rg
243.865 111.196 97.313 0.750 re f
243.865 95.315 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 101.341 Td /F1 9.8 Tf  [(44.79�4.1)] TJ ET
0.267 0.267 0.267 rg
340.428 111.196 123.536 0.750 re f
340.428 95.315 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 101.341 Td /F1 9.8 Tf  [(39.01�10.9)] TJ ET
0.267 0.267 0.267 rg
463.214 111.196 51.023 0.750 re f
463.214 95.315 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 101.341 Td /F4 9.8 Tf  [(0.523)] TJ ET
0.267 0.267 0.267 rg
513.487 111.196 67.388 0.750 re f
513.487 95.315 0.750 16.631 re f
580.125 95.315 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 101.341 Td /F4 9.8 Tf  [(0.026)] TJ ET
0.267 0.267 0.267 rg
26.625 95.315 132.554 0.750 re f
26.625 79.434 132.554 0.750 re f
26.625 79.434 0.750 16.631 re f
158.429 95.315 86.186 0.750 re f
158.429 79.434 86.186 0.750 re f
158.429 79.434 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 85.460 Td /F1 9.8 Tf  [(TC \(n=63\))] TJ ET
0.267 0.267 0.267 rg
243.865 95.315 97.313 0.750 re f
243.865 79.434 97.313 0.750 re f
243.865 79.434 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 85.460 Td /F1 9.8 Tf  [(44.01�3.7)] TJ ET
0.267 0.267 0.267 rg
340.428 95.315 123.536 0.750 re f
340.428 79.434 123.536 0.750 re f
340.428 79.434 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 85.460 Td /F1 9.8 Tf  [(42.78�9.8)] TJ ET
0.267 0.267 0.267 rg
463.214 95.315 51.023 0.750 re f
463.214 79.434 51.023 0.750 re f
463.214 79.434 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 85.460 Td /F4 9.8 Tf  [(0.523)] TJ ET
0.267 0.267 0.267 rg
513.487 95.315 67.388 0.750 re f
513.487 79.434 67.388 0.750 re f
513.487 79.434 0.750 16.631 re f
580.125 79.434 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 85.460 Td /F4 9.8 Tf  [(0.033)] TJ ET
Q
q
15.000 79.059 577.500 697.941 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(in residual AO in the respective samples. Inclusion of the )] TJ ET
BT 273.900 767.476 Td /F5 9.8 Tf  [(GRIN2B)] TJ ET
BT 310.199 767.476 Td /F1 9.8 Tf  [( genotypes in the model for motor AO \( )] TJ ET
BT 480.902 767.476 Td /F5 9.8 Tf  [(n)] TJ ET
BT 486.323 767.476 Td /F1 9.8 Tf  [( = 538\) increased the )] TJ ET
BT 26.250 755.571 Td /F1 9.8 Tf  [(R )] TJ ET
BT 36.000 759.460 Td /F1 8.7 Tf  [(2)] TJ ET
BT 40.819 755.571 Td /F1 9.8 Tf  [( statistic from 0.620 to 0.623 \(p=0.046\) and in the study of 241 patients with psychiatric AO, the R )] TJ ET
BT 463.267 759.460 Td /F1 8.7 Tf  [(2)] TJ ET
BT 468.085 755.571 Td /F1 9.8 Tf  [( statistic of the )] TJ ET
BT 26.250 743.667 Td /F1 9.8 Tf  [(exponential regression rose from 0.515 to 0.523 with the )] TJ ET
BT 272.291 743.667 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 308.591 743.667 Td /F1 9.8 Tf  [( rs1969060 genotypes included \(p=0.026, table 1\). )] TJ ET
BT 26.250 731.762 Td /F1 9.8 Tf  [(Interestingly, the association of cognitive AO \( )] TJ ET
BT 226.759 731.762 Td /F5 9.8 Tf  [(n)] TJ ET
BT 232.180 731.762 Td /F1 9.8 Tf  [( = 112\) with the )] TJ ET
BT 301.824 731.762 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 338.123 731.762 Td /F1 9.8 Tf  [( rs2650427 polymorphism shows the highest nominal )] TJ ET
BT 26.250 719.857 Td /F1 9.8 Tf  [(significance as compared to the other models in the study \(0.770 to 0.775, p=0.014\). Yet, the results remain )] TJ ET
BT 26.250 707.952 Td /F1 9.8 Tf  [(statisticallysignificant when excluding the patients with CAGs over >70 \(n=4\).)] TJ ET
1.000 1.000 1.000 rg
26.250 79.059 555.000 619.013 re f
0.753 0.753 0.753 rg
27.000 673.809 131.804 23.512 re f
0.267 0.267 0.267 rg
26.625 696.947 132.554 0.750 re f
26.625 673.434 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 31.875 687.091 Td /F1 9.8 Tf  [(Model)] TJ ET
0.753 0.753 0.753 rg
158.804 673.809 85.436 23.512 re f
0.267 0.267 0.267 rg
158.429 696.947 86.186 0.750 re f
158.429 673.434 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 163.679 687.091 Td /F1 9.8 Tf  [(Genotypes)] TJ ET
0.753 0.753 0.753 rg
244.240 673.809 96.563 23.512 re f
0.267 0.267 0.267 rg
243.865 696.947 97.313 0.750 re f
243.865 673.434 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 249.115 687.091 Td /F1 9.8 Tf  [(CAGmean � SD)] TJ ET
0.753 0.753 0.753 rg
340.803 673.809 122.786 23.512 re f
0.267 0.267 0.267 rg
340.428 696.947 123.536 0.750 re f
340.428 673.434 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 345.678 687.091 Td /F4 9.8 Tf  [(erliest AO)] TJ ET
BT 345.678 679.460 Td /F1 9.8 Tf  [(mean � SD)] TJ ET
0.753 0.753 0.753 rg
463.589 673.809 50.273 23.512 re f
0.267 0.267 0.267 rg
463.214 696.947 51.023 0.750 re f
463.214 673.434 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 468.464 687.091 Td /F1 9.8 Tf  [(R�*)] TJ ET
0.753 0.753 0.753 rg
513.862 673.809 66.638 23.512 re f
0.267 0.267 0.267 rg
513.487 696.947 67.388 0.750 re f
513.487 673.434 0.750 24.262 re f
580.125 673.434 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 518.737 687.091 Td /F1 9.8 Tf  [(P value)] TJ ET
0.600 0.600 0.600 rg
27.000 657.928 131.804 15.881 re f
0.267 0.267 0.267 rg
26.625 673.434 132.554 0.750 re f
26.625 657.553 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 663.579 Td /F1 9.8 Tf  [(HD CAG 40-89 \( )] TJ ET
BT 106.102 663.579 Td /F5 9.8 Tf  [(n)] TJ ET
BT 111.523 663.579 Td /F1 9.8 Tf  [( =1069\))] TJ ET
0.600 0.600 0.600 rg
158.804 657.928 85.436 15.881 re f
0.267 0.267 0.267 rg
158.429 673.434 86.186 0.750 re f
158.429 657.553 0.750 16.631 re f
0.600 0.600 0.600 rg
244.240 657.928 96.563 15.881 re f
0.267 0.267 0.267 rg
243.865 673.434 97.313 0.750 re f
243.865 657.553 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 663.579 Td /F1 9.8 Tf  [(44.97�4.7)] TJ ET
0.600 0.600 0.600 rg
340.803 657.928 122.786 15.881 re f
0.267 0.267 0.267 rg
340.428 673.434 123.536 0.750 re f
340.428 657.553 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 663.579 Td /F1 9.8 Tf  [(41.87�11.8)] TJ ET
0.600 0.600 0.600 rg
463.589 657.928 50.273 15.881 re f
0.267 0.267 0.267 rg
463.214 673.434 51.023 0.750 re f
463.214 657.553 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 663.579 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.600 0.600 0.600 rg
513.862 657.928 66.638 15.881 re f
0.267 0.267 0.267 rg
513.487 673.434 67.388 0.750 re f
513.487 657.553 0.750 16.631 re f
580.125 657.553 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 663.579 Td /F1 9.8 Tf  [(<0.0005)] TJ ET
0.267 0.267 0.267 rg
26.625 657.553 132.554 0.750 re f
26.625 634.040 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 31.875 647.698 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 647.698 Td /F5 9.8 Tf  [(GRIN2B)] TJ ET
BT 76.579 647.698 Td /F1 9.8 Tf  [( C2664T )] TJ ET
BT 31.875 640.067 Td /F1 9.8 Tf  [(\(rs1806201\))] TJ ET
0.267 0.267 0.267 rg
158.429 657.553 86.186 0.750 re f
158.429 634.040 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 163.679 647.698 Td /F1 9.8 Tf  [(CC \(n=560\))] TJ ET
0.267 0.267 0.267 rg
243.865 657.553 97.313 0.750 re f
243.865 634.040 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 249.115 647.698 Td /F1 9.8 Tf  [(44.94�4.8)] TJ ET
0.267 0.267 0.267 rg
340.428 657.553 123.536 0.750 re f
340.428 634.040 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 345.678 647.698 Td /F1 9.8 Tf  [(42.13�12.1)] TJ ET
0.267 0.267 0.267 rg
463.214 657.553 51.023 0.750 re f
463.214 634.040 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 468.464 647.698 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 657.553 67.388 0.750 re f
513.487 634.040 0.750 24.262 re f
580.125 634.040 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 518.737 647.698 Td /F1 9.8 Tf  [(0.541)] TJ ET
0.267 0.267 0.267 rg
26.625 634.040 132.554 0.750 re f
26.625 618.159 0.750 16.631 re f
158.429 634.040 86.186 0.750 re f
158.429 618.159 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 624.185 Td /F1 9.8 Tf  [(CT \(n=436\))] TJ ET
0.267 0.267 0.267 rg
243.865 634.040 97.313 0.750 re f
243.865 618.159 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 624.185 Td /F1 9.8 Tf  [(45.02�4.5)] TJ ET
0.267 0.267 0.267 rg
340.428 634.040 123.536 0.750 re f
340.428 618.159 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 624.185 Td /F1 9.8 Tf  [(41.32�11.3)] TJ ET
0.267 0.267 0.267 rg
463.214 634.040 51.023 0.750 re f
463.214 618.159 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 624.185 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 634.040 67.388 0.750 re f
513.487 618.159 0.750 16.631 re f
580.125 618.159 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 624.185 Td /F1 9.8 Tf  [(0.199)] TJ ET
0.267 0.267 0.267 rg
26.625 618.159 132.554 0.750 re f
26.625 602.278 0.750 16.631 re f
158.429 618.159 86.186 0.750 re f
158.429 602.278 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 608.304 Td /F1 9.8 Tf  [(TT \(n=73\))] TJ ET
0.267 0.267 0.267 rg
243.865 618.159 97.313 0.750 re f
243.865 602.278 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 608.304 Td /F1 9.8 Tf  [(44.86�4.6)] TJ ET
0.267 0.267 0.267 rg
340.428 618.159 123.536 0.750 re f
340.428 602.278 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 608.304 Td /F1 9.8 Tf  [(43.14�11.9)] TJ ET
0.267 0.267 0.267 rg
463.214 618.159 51.023 0.750 re f
463.214 602.278 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 608.304 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 618.159 67.388 0.750 re f
513.487 602.278 0.750 16.631 re f
580.125 602.278 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 608.304 Td /F1 9.8 Tf  [(0.196)] TJ ET
0.267 0.267 0.267 rg
26.625 602.278 132.554 0.750 re f
26.625 586.396 0.750 16.631 re f
158.429 602.278 86.186 0.750 re f
158.429 586.396 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 592.423 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 602.278 97.313 0.750 re f
243.865 586.396 0.750 16.631 re f
340.428 602.278 123.536 0.750 re f
340.428 586.396 0.750 16.631 re f
463.214 602.278 51.023 0.750 re f
463.214 586.396 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 592.423 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 602.278 67.388 0.750 re f
513.487 586.396 0.750 16.631 re f
580.125 586.396 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 592.423 Td /F1 9.8 Tf  [(0.973)] TJ ET
0.267 0.267 0.267 rg
26.625 586.397 132.554 0.750 re f
26.625 570.515 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 576.542 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 576.542 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 76.579 576.542 Td /F1 9.8 Tf  [( rs1969060)] TJ ET
0.267 0.267 0.267 rg
158.429 586.397 86.186 0.750 re f
158.429 570.515 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 576.542 Td /F1 9.8 Tf  [(TT \(n=745\))] TJ ET
0.267 0.267 0.267 rg
243.865 586.397 97.313 0.750 re f
243.865 570.515 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 576.542 Td /F1 9.8 Tf  [(44.83�4.5)] TJ ET
0.267 0.267 0.267 rg
340.428 586.397 123.536 0.750 re f
340.428 570.515 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 576.542 Td /F1 9.8 Tf  [(42.00�11.9)] TJ ET
0.267 0.267 0.267 rg
463.214 586.397 51.023 0.750 re f
463.214 570.515 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 576.542 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 586.397 67.388 0.750 re f
513.487 570.515 0.750 16.631 re f
580.125 570.515 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 576.542 Td /F1 9.8 Tf  [(0.160)] TJ ET
0.267 0.267 0.267 rg
26.625 570.515 132.554 0.750 re f
26.625 554.634 0.750 16.631 re f
158.429 570.515 86.186 0.750 re f
158.429 554.634 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 560.660 Td /F1 9.8 Tf  [(TC \(n=292\))] TJ ET
0.267 0.267 0.267 rg
243.865 570.515 97.313 0.750 re f
243.865 554.634 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 560.660 Td /F1 9.8 Tf  [(45.24�5.1)] TJ ET
0.267 0.267 0.267 rg
340.428 570.515 123.536 0.750 re f
340.428 554.634 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 560.660 Td /F1 9.8 Tf  [(41.67�11.5)] TJ ET
0.267 0.267 0.267 rg
463.214 570.515 51.023 0.750 re f
463.214 554.634 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 560.660 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 570.515 67.388 0.750 re f
513.487 554.634 0.750 16.631 re f
580.125 554.634 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 560.660 Td /F1 9.8 Tf  [(0.203)] TJ ET
0.267 0.267 0.267 rg
26.625 554.634 132.554 0.750 re f
26.625 538.753 0.750 16.631 re f
158.429 554.634 86.186 0.750 re f
158.429 538.753 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 544.779 Td /F1 9.8 Tf  [(CC \(n=32\))] TJ ET
0.267 0.267 0.267 rg
243.865 554.634 97.313 0.750 re f
243.865 538.753 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 544.779 Td /F1 9.8 Tf  [(45.75�4.2)] TJ ET
0.267 0.267 0.267 rg
340.428 554.634 123.536 0.750 re f
340.428 538.753 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 544.779 Td /F1 9.8 Tf  [(40.66�11.5)] TJ ET
0.267 0.267 0.267 rg
463.214 554.634 51.023 0.750 re f
463.214 538.753 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 544.779 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 554.634 67.388 0.750 re f
513.487 538.753 0.750 16.631 re f
580.125 538.753 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 544.779 Td /F1 9.8 Tf  [(0.645)] TJ ET
0.267 0.267 0.267 rg
26.625 538.753 132.554 0.750 re f
26.625 522.872 0.750 16.631 re f
158.429 538.753 86.186 0.750 re f
158.429 522.872 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 528.898 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 538.753 97.313 0.750 re f
243.865 522.872 0.750 16.631 re f
340.428 538.753 123.536 0.750 re f
340.428 522.872 0.750 16.631 re f
463.214 538.753 51.023 0.750 re f
463.214 522.872 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 528.898 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 538.753 67.388 0.750 re f
513.487 522.872 0.750 16.631 re f
580.125 522.872 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 528.898 Td /F1 9.8 Tf  [(0.172)] TJ ET
0.267 0.267 0.267 rg
26.625 522.872 132.554 0.750 re f
26.625 506.990 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 513.017 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 513.017 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 76.579 513.017 Td /F1 9.8 Tf  [( rs2650427)] TJ ET
0.267 0.267 0.267 rg
158.429 522.872 86.186 0.750 re f
158.429 506.990 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 513.017 Td /F1 9.8 Tf  [(CC \(n=374\))] TJ ET
0.267 0.267 0.267 rg
243.865 522.872 97.313 0.750 re f
243.865 506.990 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 513.017 Td /F1 9.8 Tf  [(44.99�4.0)] TJ ET
0.267 0.267 0.267 rg
340.428 522.872 123.536 0.750 re f
340.428 506.990 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 513.017 Td /F1 9.8 Tf  [(41.40�11.9)] TJ ET
0.267 0.267 0.267 rg
463.214 522.872 51.023 0.750 re f
463.214 506.990 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 513.017 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 522.872 67.388 0.750 re f
513.487 506.990 0.750 16.631 re f
580.125 506.990 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 513.017 Td /F1 9.8 Tf  [(0.125)] TJ ET
0.267 0.267 0.267 rg
26.625 506.990 132.554 0.750 re f
26.625 491.109 0.750 16.631 re f
158.429 506.990 86.186 0.750 re f
158.429 491.109 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 497.135 Td /F1 9.8 Tf  [(CT \(n=512\))] TJ ET
0.267 0.267 0.267 rg
243.865 506.990 97.313 0.750 re f
243.865 491.109 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 497.135 Td /F1 9.8 Tf  [(44.94�5.2)] TJ ET
0.267 0.267 0.267 rg
340.428 506.990 123.536 0.750 re f
340.428 491.109 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 497.135 Td /F1 9.8 Tf  [(41.99�11.9)] TJ ET
0.267 0.267 0.267 rg
463.214 506.990 51.023 0.750 re f
463.214 491.109 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 497.135 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 506.990 67.388 0.750 re f
513.487 491.109 0.750 16.631 re f
580.125 491.109 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 497.135 Td /F1 9.8 Tf  [(0.891)] TJ ET
0.267 0.267 0.267 rg
26.625 491.109 132.554 0.750 re f
26.625 475.228 0.750 16.631 re f
158.429 491.109 86.186 0.750 re f
158.429 475.228 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 481.254 Td /F1 9.8 Tf  [(TT \(n=183\))] TJ ET
0.267 0.267 0.267 rg
243.865 491.109 97.313 0.750 re f
243.865 475.228 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 481.254 Td /F1 9.8 Tf  [(42.51�4.2)] TJ ET
0.267 0.267 0.267 rg
340.428 491.109 123.536 0.750 re f
340.428 475.228 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 481.254 Td /F1 9.8 Tf  [(43.14�10.9)] TJ ET
0.267 0.267 0.267 rg
463.214 491.109 51.023 0.750 re f
463.214 475.228 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 481.254 Td /F4 9.8 Tf  [(0.635)] TJ ET
0.267 0.267 0.267 rg
513.487 491.109 67.388 0.750 re f
513.487 475.228 0.750 16.631 re f
580.125 475.228 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 481.254 Td /F4 9.8 Tf  [(0.031)] TJ ET
0.267 0.267 0.267 rg
26.625 475.228 132.554 0.750 re f
26.625 459.346 0.750 16.631 re f
158.429 475.228 86.186 0.750 re f
158.429 459.346 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 465.373 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 475.228 97.313 0.750 re f
243.865 459.346 0.750 16.631 re f
340.428 475.228 123.536 0.750 re f
340.428 459.346 0.750 16.631 re f
463.214 475.228 51.023 0.750 re f
463.214 459.346 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 465.373 Td /F4 9.8 Tf  [(0.635)] TJ ET
0.267 0.267 0.267 rg
513.487 475.228 67.388 0.750 re f
513.487 459.346 0.750 16.631 re f
580.125 459.346 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 465.373 Td /F4 9.8 Tf  [(0.028)] TJ ET
0.753 0.753 0.753 rg
27.000 436.209 131.804 23.512 re f
0.267 0.267 0.267 rg
26.625 459.346 132.554 0.750 re f
26.625 435.834 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 31.875 449.491 Td /F1 9.8 Tf  [(Model)] TJ ET
0.753 0.753 0.753 rg
158.804 436.209 85.436 23.512 re f
0.267 0.267 0.267 rg
158.429 459.346 86.186 0.750 re f
158.429 435.834 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 163.679 449.491 Td /F1 9.8 Tf  [(Genotypes)] TJ ET
0.753 0.753 0.753 rg
244.240 436.209 96.563 23.512 re f
0.267 0.267 0.267 rg
243.865 459.346 97.313 0.750 re f
243.865 435.834 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 249.115 449.491 Td /F1 9.8 Tf  [(CAGmean � SD)] TJ ET
0.753 0.753 0.753 rg
340.803 436.209 122.786 23.512 re f
0.267 0.267 0.267 rg
340.428 459.346 123.536 0.750 re f
340.428 435.834 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 345.678 449.491 Td /F4 9.8 Tf  [(motor AO)] TJ ET
BT 345.678 441.860 Td /F1 9.8 Tf  [(mean � SD)] TJ ET
0.753 0.753 0.753 rg
463.589 436.209 50.273 23.512 re f
0.267 0.267 0.267 rg
463.214 459.346 51.023 0.750 re f
463.214 435.834 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 468.464 449.491 Td /F1 9.8 Tf  [(R�*)] TJ ET
0.753 0.753 0.753 rg
513.862 436.209 66.638 23.512 re f
0.267 0.267 0.267 rg
513.487 459.346 67.388 0.750 re f
513.487 435.834 0.750 24.262 re f
580.125 435.834 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 518.737 449.491 Td /F1 9.8 Tf  [(P value)] TJ ET
0.600 0.600 0.600 rg
27.000 420.328 131.804 15.881 re f
0.267 0.267 0.267 rg
26.625 435.834 132.554 0.750 re f
26.625 419.953 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 425.979 Td /F1 9.8 Tf  [(HD CAG 40-77 \( )] TJ ET
BT 106.102 425.979 Td /F5 9.8 Tf  [(n)] TJ ET
BT 111.523 425.979 Td /F1 9.8 Tf  [( =538\))] TJ ET
0.600 0.600 0.600 rg
158.804 420.328 85.436 15.881 re f
0.267 0.267 0.267 rg
158.429 435.834 86.186 0.750 re f
158.429 419.953 0.750 16.631 re f
0.600 0.600 0.600 rg
244.240 420.328 96.563 15.881 re f
0.267 0.267 0.267 rg
243.865 435.834 97.313 0.750 re f
243.865 419.953 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 425.979 Td /F1 9.8 Tf  [(44.72�4.0)] TJ ET
0.600 0.600 0.600 rg
340.803 420.328 122.786 15.881 re f
0.267 0.267 0.267 rg
340.428 435.834 123.536 0.750 re f
340.428 419.953 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 425.979 Td /F4 9.8 Tf  [(43.39�11.6)] TJ ET
0.600 0.600 0.600 rg
463.589 420.328 50.273 15.881 re f
0.267 0.267 0.267 rg
463.214 435.834 51.023 0.750 re f
463.214 419.953 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 425.979 Td /F1 9.8 Tf  [(0.620)] TJ ET
0.600 0.600 0.600 rg
513.862 420.328 66.638 15.881 re f
0.267 0.267 0.267 rg
513.487 435.834 67.388 0.750 re f
513.487 419.953 0.750 16.631 re f
580.125 419.953 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 425.979 Td /F1 9.8 Tf  [(<0.0005)] TJ ET
0.267 0.267 0.267 rg
26.625 419.953 132.554 0.750 re f
26.625 396.440 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 31.875 410.098 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 410.098 Td /F5 9.8 Tf  [(GRIN2B)] TJ ET
BT 76.579 410.098 Td /F1 9.8 Tf  [( C2664T )] TJ ET
BT 31.875 402.466 Td /F1 9.8 Tf  [(\(rs1806201\))] TJ ET
0.267 0.267 0.267 rg
158.429 419.953 86.186 0.750 re f
158.429 396.440 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 163.679 410.098 Td /F1 9.8 Tf  [(CC \(n=274\))] TJ ET
0.267 0.267 0.267 rg
243.865 419.953 97.313 0.750 re f
243.865 396.440 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 249.115 410.098 Td /F1 9.8 Tf  [(44.52�3.8)] TJ ET
0.267 0.267 0.267 rg
340.428 419.953 123.536 0.750 re f
340.428 396.440 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 345.678 410.098 Td /F1 9.8 Tf  [(44.41�11.8)] TJ ET
0.267 0.267 0.267 rg
463.214 419.953 51.023 0.750 re f
463.214 396.440 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 468.464 410.098 Td /F1 9.8 Tf  [(0.622)] TJ ET
0.267 0.267 0.267 rg
513.487 419.953 67.388 0.750 re f
513.487 396.440 0.750 24.262 re f
580.125 396.440 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 518.737 410.098 Td /F1 9.8 Tf  [(0.099)] TJ ET
0.267 0.267 0.267 rg
26.625 396.440 132.554 0.750 re f
26.625 380.559 0.750 16.631 re f
158.429 396.440 86.186 0.750 re f
158.429 380.559 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 386.585 Td /F1 9.8 Tf  [(CT \(n=221\))] TJ ET
0.267 0.267 0.267 rg
243.865 396.440 97.313 0.750 re f
243.865 380.559 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 386.585 Td /F1 9.8 Tf  [(44.96�4.1)] TJ ET
0.267 0.267 0.267 rg
340.428 396.440 123.536 0.750 re f
340.428 380.559 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 386.585 Td /F1 9.8 Tf  [(41.98�11.1)] TJ ET
0.267 0.267 0.267 rg
463.214 396.440 51.023 0.750 re f
463.214 380.559 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 386.585 Td /F4 9.8 Tf  [(0.623)] TJ ET
0.267 0.267 0.267 rg
513.487 396.440 67.388 0.750 re f
513.487 380.559 0.750 16.631 re f
580.125 380.559 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 386.585 Td /F4 9.8 Tf  [(0.046)] TJ ET
0.267 0.267 0.267 rg
26.625 380.559 132.554 0.750 re f
26.625 364.678 0.750 16.631 re f
158.429 380.559 86.186 0.750 re f
158.429 364.678 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 370.704 Td /F1 9.8 Tf  [(TT \(n=43\))] TJ ET
0.267 0.267 0.267 rg
243.865 380.559 97.313 0.750 re f
243.865 364.678 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 370.704 Td /F1 9.8 Tf  [(44.77�4.9)] TJ ET
0.267 0.267 0.267 rg
340.428 380.559 123.536 0.750 re f
340.428 364.678 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 370.704 Td /F1 9.8 Tf  [(44.07�12.4)] TJ ET
0.267 0.267 0.267 rg
463.214 380.559 51.023 0.750 re f
463.214 364.678 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 370.704 Td /F1 9.8 Tf  [(0.620)] TJ ET
0.267 0.267 0.267 rg
513.487 380.559 67.388 0.750 re f
513.487 364.678 0.750 16.631 re f
580.125 364.678 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 370.704 Td /F1 9.8 Tf  [(0.560)] TJ ET
0.267 0.267 0.267 rg
26.625 364.678 132.554 0.750 re f
26.625 348.797 0.750 16.631 re f
158.429 364.678 86.186 0.750 re f
158.429 348.797 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 354.823 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 364.678 97.313 0.750 re f
243.865 348.797 0.750 16.631 re f
340.428 364.678 123.536 0.750 re f
340.428 348.797 0.750 16.631 re f
463.214 364.678 51.023 0.750 re f
463.214 348.797 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 354.823 Td /F1 9.8 Tf  [(0.621)] TJ ET
0.267 0.267 0.267 rg
513.487 364.678 67.388 0.750 re f
513.487 348.797 0.750 16.631 re f
580.125 348.797 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 354.823 Td /F1 9.8 Tf  [(0.296)] TJ ET
0.267 0.267 0.267 rg
26.625 348.797 132.554 0.750 re f
26.625 332.915 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 338.942 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 338.942 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 76.579 338.942 Td /F1 9.8 Tf  [( rs1969060)] TJ ET
0.267 0.267 0.267 rg
158.429 348.797 86.186 0.750 re f
158.429 332.915 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 338.942 Td /F1 9.8 Tf  [(TT \(n=373\))] TJ ET
0.267 0.267 0.267 rg
243.865 348.797 97.313 0.750 re f
243.865 332.915 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 338.942 Td /F1 9.8 Tf  [(44.51�3.6)] TJ ET
0.267 0.267 0.267 rg
340.428 348.797 123.536 0.750 re f
340.428 332.915 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 338.942 Td /F1 9.8 Tf  [(43.79�11.5)] TJ ET
0.267 0.267 0.267 rg
463.214 348.797 51.023 0.750 re f
463.214 332.915 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 338.942 Td /F1 9.8 Tf  [(0.620)] TJ ET
0.267 0.267 0.267 rg
513.487 348.797 67.388 0.750 re f
513.487 332.915 0.750 16.631 re f
580.125 332.915 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 338.942 Td /F1 9.8 Tf  [(0.824)] TJ ET
0.267 0.267 0.267 rg
26.625 332.915 132.554 0.750 re f
26.625 317.034 0.750 16.631 re f
158.429 332.915 86.186 0.750 re f
158.429 317.034 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 323.060 Td /F1 9.8 Tf  [(TC \(n=153\))] TJ ET
0.267 0.267 0.267 rg
243.865 332.915 97.313 0.750 re f
243.865 317.034 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 323.060 Td /F1 9.8 Tf  [(45.32�4.9)] TJ ET
0.267 0.267 0.267 rg
340.428 332.915 123.536 0.750 re f
340.428 317.034 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 323.060 Td /F1 9.8 Tf  [(42.19�11.9)] TJ ET
0.267 0.267 0.267 rg
463.214 332.915 51.023 0.750 re f
463.214 317.034 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 323.060 Td /F1 9.8 Tf  [(0.620)] TJ ET
0.267 0.267 0.267 rg
513.487 332.915 67.388 0.750 re f
513.487 317.034 0.750 16.631 re f
580.125 317.034 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 323.060 Td /F1 9.8 Tf  [(0.934)] TJ ET
0.267 0.267 0.267 rg
26.625 317.034 132.554 0.750 re f
26.625 301.153 0.750 16.631 re f
158.429 317.034 86.186 0.750 re f
158.429 301.153 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 307.179 Td /F1 9.8 Tf  [(CC \(n=12\))] TJ ET
0.267 0.267 0.267 rg
243.865 317.034 97.313 0.750 re f
243.865 301.153 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 307.179 Td /F1 9.8 Tf  [(43.75�2.5)] TJ ET
0.267 0.267 0.267 rg
340.428 317.034 123.536 0.750 re f
340.428 301.153 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 307.179 Td /F1 9.8 Tf  [(46.25�9.5)] TJ ET
0.267 0.267 0.267 rg
463.214 317.034 51.023 0.750 re f
463.214 301.153 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 307.179 Td /F1 9.8 Tf  [(0.620)] TJ ET
0.267 0.267 0.267 rg
513.487 317.034 67.388 0.750 re f
513.487 301.153 0.750 16.631 re f
580.125 301.153 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 307.179 Td /F1 9.8 Tf  [(0.658)] TJ ET
0.267 0.267 0.267 rg
26.625 301.153 132.554 0.750 re f
26.625 285.271 0.750 16.631 re f
158.429 301.153 86.186 0.750 re f
158.429 285.271 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 291.298 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 301.153 97.313 0.750 re f
243.865 285.271 0.750 16.631 re f
340.428 301.153 123.536 0.750 re f
340.428 285.271 0.750 16.631 re f
463.214 301.153 51.023 0.750 re f
463.214 285.271 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 291.298 Td /F1 9.8 Tf  [(0.620)] TJ ET
0.267 0.267 0.267 rg
513.487 301.153 67.388 0.750 re f
513.487 285.271 0.750 16.631 re f
580.125 285.271 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 291.298 Td /F1 9.8 Tf  [(0.744)] TJ ET
0.267 0.267 0.267 rg
26.625 285.271 132.554 0.750 re f
26.625 269.390 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 275.416 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 275.416 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 76.579 275.416 Td /F1 9.8 Tf  [( rs2650427)] TJ ET
0.267 0.267 0.267 rg
158.429 285.271 86.186 0.750 re f
158.429 269.390 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 275.416 Td /F1 9.8 Tf  [(CC \(n=181\))] TJ ET
0.267 0.267 0.267 rg
243.865 285.271 97.313 0.750 re f
243.865 269.390 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 275.416 Td /F1 9.8 Tf  [(44.15�3.8)] TJ ET
0.267 0.267 0.267 rg
340.428 285.271 123.536 0.750 re f
340.428 269.390 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 275.416 Td /F1 9.8 Tf  [(41.99�11.8)] TJ ET
0.267 0.267 0.267 rg
463.214 285.271 51.023 0.750 re f
463.214 269.390 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 275.416 Td /F1 9.8 Tf  [(0.620)] TJ ET
0.267 0.267 0.267 rg
513.487 285.271 67.388 0.750 re f
513.487 269.390 0.750 16.631 re f
580.125 269.390 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 275.416 Td /F1 9.8 Tf  [(0.362)] TJ ET
0.267 0.267 0.267 rg
26.625 269.390 132.554 0.750 re f
26.625 253.509 0.750 16.631 re f
158.429 269.390 86.186 0.750 re f
158.429 253.509 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 259.535 Td /F1 9.8 Tf  [(CT \(n=259\))] TJ ET
0.267 0.267 0.267 rg
243.865 269.390 97.313 0.750 re f
243.865 253.509 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 259.535 Td /F1 9.8 Tf  [(44.48�4.1)] TJ ET
0.267 0.267 0.267 rg
340.428 269.390 123.536 0.750 re f
340.428 253.509 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 259.535 Td /F1 9.8 Tf  [(44.00�11.9)] TJ ET
0.267 0.267 0.267 rg
463.214 269.390 51.023 0.750 re f
463.214 253.509 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 259.535 Td /F1 9.8 Tf  [(0.620)] TJ ET
0.267 0.267 0.267 rg
513.487 269.390 67.388 0.750 re f
513.487 253.509 0.750 16.631 re f
580.125 253.509 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 259.535 Td /F1 9.8 Tf  [(0.792)] TJ ET
0.267 0.267 0.267 rg
26.625 253.509 132.554 0.750 re f
26.625 237.628 0.750 16.631 re f
158.429 253.509 86.186 0.750 re f
158.429 237.628 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 243.654 Td /F1 9.8 Tf  [(TT \(n=98\))] TJ ET
0.267 0.267 0.267 rg
243.865 253.509 97.313 0.750 re f
243.865 237.628 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 243.654 Td /F1 9.8 Tf  [(44.60�4.2)] TJ ET
0.267 0.267 0.267 rg
340.428 253.509 123.536 0.750 re f
340.428 237.628 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 243.654 Td /F1 9.8 Tf  [(44.34�10.4)] TJ ET
0.267 0.267 0.267 rg
463.214 253.509 51.023 0.750 re f
463.214 237.628 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 243.654 Td /F1 9.8 Tf  [(0.621)] TJ ET
0.267 0.267 0.267 rg
513.487 253.509 67.388 0.750 re f
513.487 237.628 0.750 16.631 re f
580.125 237.628 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 243.654 Td /F1 9.8 Tf  [(0.143)] TJ ET
0.267 0.267 0.267 rg
26.625 237.628 132.554 0.750 re f
26.625 221.746 0.750 16.631 re f
158.429 237.628 86.186 0.750 re f
158.429 221.746 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 227.773 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 237.628 97.313 0.750 re f
243.865 221.746 0.750 16.631 re f
340.428 237.628 123.536 0.750 re f
340.428 221.746 0.750 16.631 re f
463.214 237.628 51.023 0.750 re f
463.214 221.746 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 227.773 Td /F1 9.8 Tf  [(0.621)] TJ ET
0.267 0.267 0.267 rg
513.487 237.628 67.388 0.750 re f
513.487 221.746 0.750 16.631 re f
580.125 221.746 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 227.773 Td /F1 9.8 Tf  [(0.158)] TJ ET
0.753 0.753 0.753 rg
27.000 198.609 131.804 23.512 re f
0.267 0.267 0.267 rg
26.625 221.746 132.554 0.750 re f
26.625 198.234 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 31.875 211.891 Td /F1 9.8 Tf  [(Model)] TJ ET
0.753 0.753 0.753 rg
158.804 198.609 85.436 23.512 re f
0.267 0.267 0.267 rg
158.429 221.746 86.186 0.750 re f
158.429 198.234 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 163.679 211.891 Td /F1 9.8 Tf  [(Genotypes)] TJ ET
0.753 0.753 0.753 rg
244.240 198.609 96.563 23.512 re f
0.267 0.267 0.267 rg
243.865 221.746 97.313 0.750 re f
243.865 198.234 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 249.115 211.891 Td /F1 9.8 Tf  [(CAGmean � SD)] TJ ET
0.753 0.753 0.753 rg
340.803 198.609 122.786 23.512 re f
0.267 0.267 0.267 rg
340.428 221.746 123.536 0.750 re f
340.428 198.234 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 345.678 211.891 Td /F4 9.8 Tf  [(psychiatric AO)] TJ ET
BT 414.493 211.891 Td /F1 9.8 Tf  [(mean � )] TJ ET
BT 345.678 204.260 Td /F1 9.8 Tf  [(SD)] TJ ET
0.753 0.753 0.753 rg
463.589 198.609 50.273 23.512 re f
0.267 0.267 0.267 rg
463.214 221.746 51.023 0.750 re f
463.214 198.234 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 468.464 211.891 Td /F1 9.8 Tf  [(R�*)] TJ ET
0.753 0.753 0.753 rg
513.862 198.609 66.638 23.512 re f
0.267 0.267 0.267 rg
513.487 221.746 67.388 0.750 re f
513.487 198.234 0.750 24.262 re f
580.125 198.234 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 518.737 211.891 Td /F1 9.8 Tf  [(P value)] TJ ET
0.600 0.600 0.600 rg
27.000 182.728 131.804 15.881 re f
0.267 0.267 0.267 rg
26.625 198.234 132.554 0.750 re f
26.625 182.353 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 188.379 Td /F1 9.8 Tf  [(HD CAG 40-67 \( )] TJ ET
BT 106.102 188.379 Td /F5 9.8 Tf  [(n)] TJ ET
BT 111.523 188.379 Td /F1 9.8 Tf  [( =241\))] TJ ET
0.600 0.600 0.600 rg
158.804 182.728 85.436 15.881 re f
0.267 0.267 0.267 rg
158.429 198.234 86.186 0.750 re f
158.429 182.353 0.750 16.631 re f
0.600 0.600 0.600 rg
244.240 182.728 96.563 15.881 re f
0.267 0.267 0.267 rg
243.865 198.234 97.313 0.750 re f
243.865 182.353 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 188.379 Td /F1 9.8 Tf  [(44.73�4.1)] TJ ET
0.600 0.600 0.600 rg
340.803 182.728 122.786 15.881 re f
0.267 0.267 0.267 rg
340.428 198.234 123.536 0.750 re f
340.428 182.353 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 188.379 Td /F4 9.8 Tf  [(39.86�10.8)] TJ ET
0.600 0.600 0.600 rg
463.589 182.728 50.273 15.881 re f
0.267 0.267 0.267 rg
463.214 198.234 51.023 0.750 re f
463.214 182.353 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 188.379 Td /F1 9.8 Tf  [(0.515)] TJ ET
0.600 0.600 0.600 rg
513.862 182.728 66.638 15.881 re f
0.267 0.267 0.267 rg
513.487 198.234 67.388 0.750 re f
513.487 182.353 0.750 16.631 re f
580.125 182.353 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 188.379 Td /F1 9.8 Tf  [(<0.0005)] TJ ET
0.267 0.267 0.267 rg
26.625 182.353 132.554 0.750 re f
26.625 158.840 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 31.875 172.498 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 172.498 Td /F5 9.8 Tf  [(GRIN2B)] TJ ET
BT 76.579 172.498 Td /F1 9.8 Tf  [( C2664T )] TJ ET
BT 31.875 164.866 Td /F1 9.8 Tf  [(\(rs1806201\))] TJ ET
0.267 0.267 0.267 rg
158.429 182.353 86.186 0.750 re f
158.429 158.840 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 163.679 172.498 Td /F1 9.8 Tf  [(CC \(n=139\))] TJ ET
0.267 0.267 0.267 rg
243.865 182.353 97.313 0.750 re f
243.865 158.840 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 249.115 172.498 Td /F1 9.8 Tf  [(44.81�4.4)] TJ ET
0.267 0.267 0.267 rg
340.428 182.353 123.536 0.750 re f
340.428 158.840 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 345.678 172.498 Td /F1 9.8 Tf  [(39.50�11.3)] TJ ET
0.267 0.267 0.267 rg
463.214 182.353 51.023 0.750 re f
463.214 158.840 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 468.464 172.498 Td /F1 9.8 Tf  [(0.513)] TJ ET
0.267 0.267 0.267 rg
513.487 182.353 67.388 0.750 re f
513.487 158.840 0.750 24.262 re f
580.125 158.840 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 518.737 172.498 Td /F1 9.8 Tf  [(0.964)] TJ ET
0.267 0.267 0.267 rg
26.625 158.840 132.554 0.750 re f
26.625 142.959 0.750 16.631 re f
158.429 158.840 86.186 0.750 re f
158.429 142.959 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 148.985 Td /F1 9.8 Tf  [(CT \(n=90\))] TJ ET
0.267 0.267 0.267 rg
243.865 158.840 97.313 0.750 re f
243.865 142.959 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 148.985 Td /F1 9.8 Tf  [(44.74�3.8)] TJ ET
0.267 0.267 0.267 rg
340.428 158.840 123.536 0.750 re f
340.428 142.959 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 148.985 Td /F1 9.8 Tf  [(39.79�10.5)] TJ ET
0.267 0.267 0.267 rg
463.214 158.840 51.023 0.750 re f
463.214 142.959 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 148.985 Td /F1 9.8 Tf  [(0.514)] TJ ET
0.267 0.267 0.267 rg
513.487 158.840 67.388 0.750 re f
513.487 142.959 0.750 16.631 re f
580.125 142.959 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 148.985 Td /F1 9.8 Tf  [(0.607)] TJ ET
0.267 0.267 0.267 rg
26.625 142.959 132.554 0.750 re f
26.625 127.078 0.750 16.631 re f
158.429 142.959 86.186 0.750 re f
158.429 127.078 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 133.104 Td /F1 9.8 Tf  [(TT \(n=12\))] TJ ET
0.267 0.267 0.267 rg
243.865 142.959 97.313 0.750 re f
243.865 127.078 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 133.104 Td /F1 9.8 Tf  [(43.67�2.1)] TJ ET
0.267 0.267 0.267 rg
340.428 142.959 123.536 0.750 re f
340.428 127.078 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 133.104 Td /F1 9.8 Tf  [(44.58�9.6)] TJ ET
0.267 0.267 0.267 rg
463.214 142.959 51.023 0.750 re f
463.214 127.078 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 133.104 Td /F1 9.8 Tf  [(0.517)] TJ ET
0.267 0.267 0.267 rg
513.487 142.959 67.388 0.750 re f
513.487 127.078 0.750 16.631 re f
580.125 127.078 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 133.104 Td /F1 9.8 Tf  [(0.211)] TJ ET
0.267 0.267 0.267 rg
26.625 127.078 132.554 0.750 re f
26.625 111.196 0.750 16.631 re f
158.429 127.078 86.186 0.750 re f
158.429 111.196 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 117.223 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 127.078 97.313 0.750 re f
243.865 111.196 0.750 16.631 re f
340.428 127.078 123.536 0.750 re f
340.428 111.196 0.750 16.631 re f
463.214 127.078 51.023 0.750 re f
463.214 111.196 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 117.223 Td /F1 9.8 Tf  [(0.514)] TJ ET
0.267 0.267 0.267 rg
513.487 127.078 67.388 0.750 re f
513.487 111.196 0.750 16.631 re f
580.125 111.196 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 117.223 Td /F1 9.8 Tf  [(0.618)] TJ ET
0.267 0.267 0.267 rg
26.625 111.196 132.554 0.750 re f
26.625 95.315 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 101.341 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 101.341 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 76.579 101.341 Td /F1 9.8 Tf  [( rs1969060)] TJ ET
0.267 0.267 0.267 rg
158.429 111.196 86.186 0.750 re f
158.429 95.315 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 101.341 Td /F1 9.8 Tf  [(TT \(n=172\))] TJ ET
0.267 0.267 0.267 rg
243.865 111.196 97.313 0.750 re f
243.865 95.315 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 101.341 Td /F1 9.8 Tf  [(44.79�4.1)] TJ ET
0.267 0.267 0.267 rg
340.428 111.196 123.536 0.750 re f
340.428 95.315 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 101.341 Td /F1 9.8 Tf  [(39.01�10.9)] TJ ET
0.267 0.267 0.267 rg
463.214 111.196 51.023 0.750 re f
463.214 95.315 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 101.341 Td /F4 9.8 Tf  [(0.523)] TJ ET
0.267 0.267 0.267 rg
513.487 111.196 67.388 0.750 re f
513.487 95.315 0.750 16.631 re f
580.125 95.315 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 101.341 Td /F4 9.8 Tf  [(0.026)] TJ ET
0.267 0.267 0.267 rg
26.625 95.315 132.554 0.750 re f
26.625 79.434 132.554 0.750 re f
26.625 79.434 0.750 16.631 re f
158.429 95.315 86.186 0.750 re f
158.429 79.434 86.186 0.750 re f
158.429 79.434 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 85.460 Td /F1 9.8 Tf  [(TC \(n=63\))] TJ ET
0.267 0.267 0.267 rg
243.865 95.315 97.313 0.750 re f
243.865 79.434 97.313 0.750 re f
243.865 79.434 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 85.460 Td /F1 9.8 Tf  [(44.01�3.7)] TJ ET
0.267 0.267 0.267 rg
340.428 95.315 123.536 0.750 re f
340.428 79.434 123.536 0.750 re f
340.428 79.434 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 85.460 Td /F1 9.8 Tf  [(42.78�9.8)] TJ ET
0.267 0.267 0.267 rg
463.214 95.315 51.023 0.750 re f
463.214 79.434 51.023 0.750 re f
463.214 79.434 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 85.460 Td /F4 9.8 Tf  [(0.523)] TJ ET
0.267 0.267 0.267 rg
513.487 95.315 67.388 0.750 re f
513.487 79.434 67.388 0.750 re f
513.487 79.434 0.750 16.631 re f
580.125 79.434 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 85.460 Td /F4 9.8 Tf  [(0.033)] TJ ET
Q
q
15.000 79.059 577.500 697.941 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(in residual AO in the respective samples. Inclusion of the )] TJ ET
BT 273.900 767.476 Td /F5 9.8 Tf  [(GRIN2B)] TJ ET
BT 310.199 767.476 Td /F1 9.8 Tf  [( genotypes in the model for motor AO \( )] TJ ET
BT 480.902 767.476 Td /F5 9.8 Tf  [(n)] TJ ET
BT 486.323 767.476 Td /F1 9.8 Tf  [( = 538\) increased the )] TJ ET
BT 26.250 755.571 Td /F1 9.8 Tf  [(R )] TJ ET
BT 36.000 759.460 Td /F1 8.7 Tf  [(2)] TJ ET
BT 40.819 755.571 Td /F1 9.8 Tf  [( statistic from 0.620 to 0.623 \(p=0.046\) and in the study of 241 patients with psychiatric AO, the R )] TJ ET
BT 463.267 759.460 Td /F1 8.7 Tf  [(2)] TJ ET
BT 468.085 755.571 Td /F1 9.8 Tf  [( statistic of the )] TJ ET
BT 26.250 743.667 Td /F1 9.8 Tf  [(exponential regression rose from 0.515 to 0.523 with the )] TJ ET
BT 272.291 743.667 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 308.591 743.667 Td /F1 9.8 Tf  [( rs1969060 genotypes included \(p=0.026, table 1\). )] TJ ET
BT 26.250 731.762 Td /F1 9.8 Tf  [(Interestingly, the association of cognitive AO \( )] TJ ET
BT 226.759 731.762 Td /F5 9.8 Tf  [(n)] TJ ET
BT 232.180 731.762 Td /F1 9.8 Tf  [( = 112\) with the )] TJ ET
BT 301.824 731.762 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 338.123 731.762 Td /F1 9.8 Tf  [( rs2650427 polymorphism shows the highest nominal )] TJ ET
BT 26.250 719.857 Td /F1 9.8 Tf  [(significance as compared to the other models in the study \(0.770 to 0.775, p=0.014\). Yet, the results remain )] TJ ET
BT 26.250 707.952 Td /F1 9.8 Tf  [(statisticallysignificant when excluding the patients with CAGs over >70 \(n=4\).)] TJ ET
1.000 1.000 1.000 rg
26.250 79.059 555.000 619.013 re f
0.753 0.753 0.753 rg
27.000 673.809 131.804 23.512 re f
0.267 0.267 0.267 rg
26.625 696.947 132.554 0.750 re f
26.625 673.434 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 31.875 687.091 Td /F1 9.8 Tf  [(Model)] TJ ET
0.753 0.753 0.753 rg
158.804 673.809 85.436 23.512 re f
0.267 0.267 0.267 rg
158.429 696.947 86.186 0.750 re f
158.429 673.434 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 163.679 687.091 Td /F1 9.8 Tf  [(Genotypes)] TJ ET
0.753 0.753 0.753 rg
244.240 673.809 96.563 23.512 re f
0.267 0.267 0.267 rg
243.865 696.947 97.313 0.750 re f
243.865 673.434 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 249.115 687.091 Td /F1 9.8 Tf  [(CAGmean � SD)] TJ ET
0.753 0.753 0.753 rg
340.803 673.809 122.786 23.512 re f
0.267 0.267 0.267 rg
340.428 696.947 123.536 0.750 re f
340.428 673.434 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 345.678 687.091 Td /F4 9.8 Tf  [(erliest AO)] TJ ET
BT 345.678 679.460 Td /F1 9.8 Tf  [(mean � SD)] TJ ET
0.753 0.753 0.753 rg
463.589 673.809 50.273 23.512 re f
0.267 0.267 0.267 rg
463.214 696.947 51.023 0.750 re f
463.214 673.434 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 468.464 687.091 Td /F1 9.8 Tf  [(R�*)] TJ ET
0.753 0.753 0.753 rg
513.862 673.809 66.638 23.512 re f
0.267 0.267 0.267 rg
513.487 696.947 67.388 0.750 re f
513.487 673.434 0.750 24.262 re f
580.125 673.434 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 518.737 687.091 Td /F1 9.8 Tf  [(P value)] TJ ET
0.600 0.600 0.600 rg
27.000 657.928 131.804 15.881 re f
0.267 0.267 0.267 rg
26.625 673.434 132.554 0.750 re f
26.625 657.553 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 663.579 Td /F1 9.8 Tf  [(HD CAG 40-89 \( )] TJ ET
BT 106.102 663.579 Td /F5 9.8 Tf  [(n)] TJ ET
BT 111.523 663.579 Td /F1 9.8 Tf  [( =1069\))] TJ ET
0.600 0.600 0.600 rg
158.804 657.928 85.436 15.881 re f
0.267 0.267 0.267 rg
158.429 673.434 86.186 0.750 re f
158.429 657.553 0.750 16.631 re f
0.600 0.600 0.600 rg
244.240 657.928 96.563 15.881 re f
0.267 0.267 0.267 rg
243.865 673.434 97.313 0.750 re f
243.865 657.553 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 663.579 Td /F1 9.8 Tf  [(44.97�4.7)] TJ ET
0.600 0.600 0.600 rg
340.803 657.928 122.786 15.881 re f
0.267 0.267 0.267 rg
340.428 673.434 123.536 0.750 re f
340.428 657.553 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 663.579 Td /F1 9.8 Tf  [(41.87�11.8)] TJ ET
0.600 0.600 0.600 rg
463.589 657.928 50.273 15.881 re f
0.267 0.267 0.267 rg
463.214 673.434 51.023 0.750 re f
463.214 657.553 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 663.579 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.600 0.600 0.600 rg
513.862 657.928 66.638 15.881 re f
0.267 0.267 0.267 rg
513.487 673.434 67.388 0.750 re f
513.487 657.553 0.750 16.631 re f
580.125 657.553 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 663.579 Td /F1 9.8 Tf  [(<0.0005)] TJ ET
0.267 0.267 0.267 rg
26.625 657.553 132.554 0.750 re f
26.625 634.040 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 31.875 647.698 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 647.698 Td /F5 9.8 Tf  [(GRIN2B)] TJ ET
BT 76.579 647.698 Td /F1 9.8 Tf  [( C2664T )] TJ ET
BT 31.875 640.067 Td /F1 9.8 Tf  [(\(rs1806201\))] TJ ET
0.267 0.267 0.267 rg
158.429 657.553 86.186 0.750 re f
158.429 634.040 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 163.679 647.698 Td /F1 9.8 Tf  [(CC \(n=560\))] TJ ET
0.267 0.267 0.267 rg
243.865 657.553 97.313 0.750 re f
243.865 634.040 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 249.115 647.698 Td /F1 9.8 Tf  [(44.94�4.8)] TJ ET
0.267 0.267 0.267 rg
340.428 657.553 123.536 0.750 re f
340.428 634.040 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 345.678 647.698 Td /F1 9.8 Tf  [(42.13�12.1)] TJ ET
0.267 0.267 0.267 rg
463.214 657.553 51.023 0.750 re f
463.214 634.040 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 468.464 647.698 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 657.553 67.388 0.750 re f
513.487 634.040 0.750 24.262 re f
580.125 634.040 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 518.737 647.698 Td /F1 9.8 Tf  [(0.541)] TJ ET
0.267 0.267 0.267 rg
26.625 634.040 132.554 0.750 re f
26.625 618.159 0.750 16.631 re f
158.429 634.040 86.186 0.750 re f
158.429 618.159 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 624.185 Td /F1 9.8 Tf  [(CT \(n=436\))] TJ ET
0.267 0.267 0.267 rg
243.865 634.040 97.313 0.750 re f
243.865 618.159 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 624.185 Td /F1 9.8 Tf  [(45.02�4.5)] TJ ET
0.267 0.267 0.267 rg
340.428 634.040 123.536 0.750 re f
340.428 618.159 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 624.185 Td /F1 9.8 Tf  [(41.32�11.3)] TJ ET
0.267 0.267 0.267 rg
463.214 634.040 51.023 0.750 re f
463.214 618.159 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 624.185 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 634.040 67.388 0.750 re f
513.487 618.159 0.750 16.631 re f
580.125 618.159 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 624.185 Td /F1 9.8 Tf  [(0.199)] TJ ET
0.267 0.267 0.267 rg
26.625 618.159 132.554 0.750 re f
26.625 602.278 0.750 16.631 re f
158.429 618.159 86.186 0.750 re f
158.429 602.278 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 608.304 Td /F1 9.8 Tf  [(TT \(n=73\))] TJ ET
0.267 0.267 0.267 rg
243.865 618.159 97.313 0.750 re f
243.865 602.278 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 608.304 Td /F1 9.8 Tf  [(44.86�4.6)] TJ ET
0.267 0.267 0.267 rg
340.428 618.159 123.536 0.750 re f
340.428 602.278 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 608.304 Td /F1 9.8 Tf  [(43.14�11.9)] TJ ET
0.267 0.267 0.267 rg
463.214 618.159 51.023 0.750 re f
463.214 602.278 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 608.304 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 618.159 67.388 0.750 re f
513.487 602.278 0.750 16.631 re f
580.125 602.278 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 608.304 Td /F1 9.8 Tf  [(0.196)] TJ ET
0.267 0.267 0.267 rg
26.625 602.278 132.554 0.750 re f
26.625 586.396 0.750 16.631 re f
158.429 602.278 86.186 0.750 re f
158.429 586.396 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 592.423 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 602.278 97.313 0.750 re f
243.865 586.396 0.750 16.631 re f
340.428 602.278 123.536 0.750 re f
340.428 586.396 0.750 16.631 re f
463.214 602.278 51.023 0.750 re f
463.214 586.396 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 592.423 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 602.278 67.388 0.750 re f
513.487 586.396 0.750 16.631 re f
580.125 586.396 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 592.423 Td /F1 9.8 Tf  [(0.973)] TJ ET
0.267 0.267 0.267 rg
26.625 586.397 132.554 0.750 re f
26.625 570.515 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 576.542 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 576.542 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 76.579 576.542 Td /F1 9.8 Tf  [( rs1969060)] TJ ET
0.267 0.267 0.267 rg
158.429 586.397 86.186 0.750 re f
158.429 570.515 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 576.542 Td /F1 9.8 Tf  [(TT \(n=745\))] TJ ET
0.267 0.267 0.267 rg
243.865 586.397 97.313 0.750 re f
243.865 570.515 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 576.542 Td /F1 9.8 Tf  [(44.83�4.5)] TJ ET
0.267 0.267 0.267 rg
340.428 586.397 123.536 0.750 re f
340.428 570.515 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 576.542 Td /F1 9.8 Tf  [(42.00�11.9)] TJ ET
0.267 0.267 0.267 rg
463.214 586.397 51.023 0.750 re f
463.214 570.515 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 576.542 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 586.397 67.388 0.750 re f
513.487 570.515 0.750 16.631 re f
580.125 570.515 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 576.542 Td /F1 9.8 Tf  [(0.160)] TJ ET
0.267 0.267 0.267 rg
26.625 570.515 132.554 0.750 re f
26.625 554.634 0.750 16.631 re f
158.429 570.515 86.186 0.750 re f
158.429 554.634 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 560.660 Td /F1 9.8 Tf  [(TC \(n=292\))] TJ ET
0.267 0.267 0.267 rg
243.865 570.515 97.313 0.750 re f
243.865 554.634 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 560.660 Td /F1 9.8 Tf  [(45.24�5.1)] TJ ET
0.267 0.267 0.267 rg
340.428 570.515 123.536 0.750 re f
340.428 554.634 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 560.660 Td /F1 9.8 Tf  [(41.67�11.5)] TJ ET
0.267 0.267 0.267 rg
463.214 570.515 51.023 0.750 re f
463.214 554.634 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 560.660 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 570.515 67.388 0.750 re f
513.487 554.634 0.750 16.631 re f
580.125 554.634 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 560.660 Td /F1 9.8 Tf  [(0.203)] TJ ET
0.267 0.267 0.267 rg
26.625 554.634 132.554 0.750 re f
26.625 538.753 0.750 16.631 re f
158.429 554.634 86.186 0.750 re f
158.429 538.753 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 544.779 Td /F1 9.8 Tf  [(CC \(n=32\))] TJ ET
0.267 0.267 0.267 rg
243.865 554.634 97.313 0.750 re f
243.865 538.753 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 544.779 Td /F1 9.8 Tf  [(45.75�4.2)] TJ ET
0.267 0.267 0.267 rg
340.428 554.634 123.536 0.750 re f
340.428 538.753 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 544.779 Td /F1 9.8 Tf  [(40.66�11.5)] TJ ET
0.267 0.267 0.267 rg
463.214 554.634 51.023 0.750 re f
463.214 538.753 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 544.779 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 554.634 67.388 0.750 re f
513.487 538.753 0.750 16.631 re f
580.125 538.753 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 544.779 Td /F1 9.8 Tf  [(0.645)] TJ ET
0.267 0.267 0.267 rg
26.625 538.753 132.554 0.750 re f
26.625 522.872 0.750 16.631 re f
158.429 538.753 86.186 0.750 re f
158.429 522.872 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 528.898 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 538.753 97.313 0.750 re f
243.865 522.872 0.750 16.631 re f
340.428 538.753 123.536 0.750 re f
340.428 522.872 0.750 16.631 re f
463.214 538.753 51.023 0.750 re f
463.214 522.872 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 528.898 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 538.753 67.388 0.750 re f
513.487 522.872 0.750 16.631 re f
580.125 522.872 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 528.898 Td /F1 9.8 Tf  [(0.172)] TJ ET
0.267 0.267 0.267 rg
26.625 522.872 132.554 0.750 re f
26.625 506.990 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 513.017 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 513.017 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 76.579 513.017 Td /F1 9.8 Tf  [( rs2650427)] TJ ET
0.267 0.267 0.267 rg
158.429 522.872 86.186 0.750 re f
158.429 506.990 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 513.017 Td /F1 9.8 Tf  [(CC \(n=374\))] TJ ET
0.267 0.267 0.267 rg
243.865 522.872 97.313 0.750 re f
243.865 506.990 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 513.017 Td /F1 9.8 Tf  [(44.99�4.0)] TJ ET
0.267 0.267 0.267 rg
340.428 522.872 123.536 0.750 re f
340.428 506.990 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 513.017 Td /F1 9.8 Tf  [(41.40�11.9)] TJ ET
0.267 0.267 0.267 rg
463.214 522.872 51.023 0.750 re f
463.214 506.990 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 513.017 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 522.872 67.388 0.750 re f
513.487 506.990 0.750 16.631 re f
580.125 506.990 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 513.017 Td /F1 9.8 Tf  [(0.125)] TJ ET
0.267 0.267 0.267 rg
26.625 506.990 132.554 0.750 re f
26.625 491.109 0.750 16.631 re f
158.429 506.990 86.186 0.750 re f
158.429 491.109 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 497.135 Td /F1 9.8 Tf  [(CT \(n=512\))] TJ ET
0.267 0.267 0.267 rg
243.865 506.990 97.313 0.750 re f
243.865 491.109 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 497.135 Td /F1 9.8 Tf  [(44.94�5.2)] TJ ET
0.267 0.267 0.267 rg
340.428 506.990 123.536 0.750 re f
340.428 491.109 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 497.135 Td /F1 9.8 Tf  [(41.99�11.9)] TJ ET
0.267 0.267 0.267 rg
463.214 506.990 51.023 0.750 re f
463.214 491.109 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 497.135 Td /F1 9.8 Tf  [(0.634)] TJ ET
0.267 0.267 0.267 rg
513.487 506.990 67.388 0.750 re f
513.487 491.109 0.750 16.631 re f
580.125 491.109 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 497.135 Td /F1 9.8 Tf  [(0.891)] TJ ET
0.267 0.267 0.267 rg
26.625 491.109 132.554 0.750 re f
26.625 475.228 0.750 16.631 re f
158.429 491.109 86.186 0.750 re f
158.429 475.228 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 481.254 Td /F1 9.8 Tf  [(TT \(n=183\))] TJ ET
0.267 0.267 0.267 rg
243.865 491.109 97.313 0.750 re f
243.865 475.228 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 481.254 Td /F1 9.8 Tf  [(42.51�4.2)] TJ ET
0.267 0.267 0.267 rg
340.428 491.109 123.536 0.750 re f
340.428 475.228 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 481.254 Td /F1 9.8 Tf  [(43.14�10.9)] TJ ET
0.267 0.267 0.267 rg
463.214 491.109 51.023 0.750 re f
463.214 475.228 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 481.254 Td /F4 9.8 Tf  [(0.635)] TJ ET
0.267 0.267 0.267 rg
513.487 491.109 67.388 0.750 re f
513.487 475.228 0.750 16.631 re f
580.125 475.228 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 481.254 Td /F4 9.8 Tf  [(0.031)] TJ ET
0.267 0.267 0.267 rg
26.625 475.228 132.554 0.750 re f
26.625 459.346 0.750 16.631 re f
158.429 475.228 86.186 0.750 re f
158.429 459.346 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 465.373 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 475.228 97.313 0.750 re f
243.865 459.346 0.750 16.631 re f
340.428 475.228 123.536 0.750 re f
340.428 459.346 0.750 16.631 re f
463.214 475.228 51.023 0.750 re f
463.214 459.346 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 465.373 Td /F4 9.8 Tf  [(0.635)] TJ ET
0.267 0.267 0.267 rg
513.487 475.228 67.388 0.750 re f
513.487 459.346 0.750 16.631 re f
580.125 459.346 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 465.373 Td /F4 9.8 Tf  [(0.028)] TJ ET
0.753 0.753 0.753 rg
27.000 436.209 131.804 23.512 re f
0.267 0.267 0.267 rg
26.625 459.346 132.554 0.750 re f
26.625 435.834 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 31.875 449.491 Td /F1 9.8 Tf  [(Model)] TJ ET
0.753 0.753 0.753 rg
158.804 436.209 85.436 23.512 re f
0.267 0.267 0.267 rg
158.429 459.346 86.186 0.750 re f
158.429 435.834 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 163.679 449.491 Td /F1 9.8 Tf  [(Genotypes)] TJ ET
0.753 0.753 0.753 rg
244.240 436.209 96.563 23.512 re f
0.267 0.267 0.267 rg
243.865 459.346 97.313 0.750 re f
243.865 435.834 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 249.115 449.491 Td /F1 9.8 Tf  [(CAGmean � SD)] TJ ET
0.753 0.753 0.753 rg
340.803 436.209 122.786 23.512 re f
0.267 0.267 0.267 rg
340.428 459.346 123.536 0.750 re f
340.428 435.834 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 345.678 449.491 Td /F4 9.8 Tf  [(motor AO)] TJ ET
BT 345.678 441.860 Td /F1 9.8 Tf  [(mean � SD)] TJ ET
0.753 0.753 0.753 rg
463.589 436.209 50.273 23.512 re f
0.267 0.267 0.267 rg
463.214 459.346 51.023 0.750 re f
463.214 435.834 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 468.464 449.491 Td /F1 9.8 Tf  [(R�*)] TJ ET
0.753 0.753 0.753 rg
513.862 436.209 66.638 23.512 re f
0.267 0.267 0.267 rg
513.487 459.346 67.388 0.750 re f
513.487 435.834 0.750 24.262 re f
580.125 435.834 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 518.737 449.491 Td /F1 9.8 Tf  [(P value)] TJ ET
0.600 0.600 0.600 rg
27.000 420.328 131.804 15.881 re f
0.267 0.267 0.267 rg
26.625 435.834 132.554 0.750 re f
26.625 419.953 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 425.979 Td /F1 9.8 Tf  [(HD CAG 40-77 \( )] TJ ET
BT 106.102 425.979 Td /F5 9.8 Tf  [(n)] TJ ET
BT 111.523 425.979 Td /F1 9.8 Tf  [( =538\))] TJ ET
0.600 0.600 0.600 rg
158.804 420.328 85.436 15.881 re f
0.267 0.267 0.267 rg
158.429 435.834 86.186 0.750 re f
158.429 419.953 0.750 16.631 re f
0.600 0.600 0.600 rg
244.240 420.328 96.563 15.881 re f
0.267 0.267 0.267 rg
243.865 435.834 97.313 0.750 re f
243.865 419.953 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 425.979 Td /F1 9.8 Tf  [(44.72�4.0)] TJ ET
0.600 0.600 0.600 rg
340.803 420.328 122.786 15.881 re f
0.267 0.267 0.267 rg
340.428 435.834 123.536 0.750 re f
340.428 419.953 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 425.979 Td /F4 9.8 Tf  [(43.39�11.6)] TJ ET
0.600 0.600 0.600 rg
463.589 420.328 50.273 15.881 re f
0.267 0.267 0.267 rg
463.214 435.834 51.023 0.750 re f
463.214 419.953 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 425.979 Td /F1 9.8 Tf  [(0.620)] TJ ET
0.600 0.600 0.600 rg
513.862 420.328 66.638 15.881 re f
0.267 0.267 0.267 rg
513.487 435.834 67.388 0.750 re f
513.487 419.953 0.750 16.631 re f
580.125 419.953 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 425.979 Td /F1 9.8 Tf  [(<0.0005)] TJ ET
0.267 0.267 0.267 rg
26.625 419.953 132.554 0.750 re f
26.625 396.440 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 31.875 410.098 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 410.098 Td /F5 9.8 Tf  [(GRIN2B)] TJ ET
BT 76.579 410.098 Td /F1 9.8 Tf  [( C2664T )] TJ ET
BT 31.875 402.466 Td /F1 9.8 Tf  [(\(rs1806201\))] TJ ET
0.267 0.267 0.267 rg
158.429 419.953 86.186 0.750 re f
158.429 396.440 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 163.679 410.098 Td /F1 9.8 Tf  [(CC \(n=274\))] TJ ET
0.267 0.267 0.267 rg
243.865 419.953 97.313 0.750 re f
243.865 396.440 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 249.115 410.098 Td /F1 9.8 Tf  [(44.52�3.8)] TJ ET
0.267 0.267 0.267 rg
340.428 419.953 123.536 0.750 re f
340.428 396.440 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 345.678 410.098 Td /F1 9.8 Tf  [(44.41�11.8)] TJ ET
0.267 0.267 0.267 rg
463.214 419.953 51.023 0.750 re f
463.214 396.440 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 468.464 410.098 Td /F1 9.8 Tf  [(0.622)] TJ ET
0.267 0.267 0.267 rg
513.487 419.953 67.388 0.750 re f
513.487 396.440 0.750 24.262 re f
580.125 396.440 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 518.737 410.098 Td /F1 9.8 Tf  [(0.099)] TJ ET
0.267 0.267 0.267 rg
26.625 396.440 132.554 0.750 re f
26.625 380.559 0.750 16.631 re f
158.429 396.440 86.186 0.750 re f
158.429 380.559 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 386.585 Td /F1 9.8 Tf  [(CT \(n=221\))] TJ ET
0.267 0.267 0.267 rg
243.865 396.440 97.313 0.750 re f
243.865 380.559 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 386.585 Td /F1 9.8 Tf  [(44.96�4.1)] TJ ET
0.267 0.267 0.267 rg
340.428 396.440 123.536 0.750 re f
340.428 380.559 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 386.585 Td /F1 9.8 Tf  [(41.98�11.1)] TJ ET
0.267 0.267 0.267 rg
463.214 396.440 51.023 0.750 re f
463.214 380.559 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 386.585 Td /F4 9.8 Tf  [(0.623)] TJ ET
0.267 0.267 0.267 rg
513.487 396.440 67.388 0.750 re f
513.487 380.559 0.750 16.631 re f
580.125 380.559 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 386.585 Td /F4 9.8 Tf  [(0.046)] TJ ET
0.267 0.267 0.267 rg
26.625 380.559 132.554 0.750 re f
26.625 364.678 0.750 16.631 re f
158.429 380.559 86.186 0.750 re f
158.429 364.678 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 370.704 Td /F1 9.8 Tf  [(TT \(n=43\))] TJ ET
0.267 0.267 0.267 rg
243.865 380.559 97.313 0.750 re f
243.865 364.678 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 370.704 Td /F1 9.8 Tf  [(44.77�4.9)] TJ ET
0.267 0.267 0.267 rg
340.428 380.559 123.536 0.750 re f
340.428 364.678 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 370.704 Td /F1 9.8 Tf  [(44.07�12.4)] TJ ET
0.267 0.267 0.267 rg
463.214 380.559 51.023 0.750 re f
463.214 364.678 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 370.704 Td /F1 9.8 Tf  [(0.620)] TJ ET
0.267 0.267 0.267 rg
513.487 380.559 67.388 0.750 re f
513.487 364.678 0.750 16.631 re f
580.125 364.678 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 370.704 Td /F1 9.8 Tf  [(0.560)] TJ ET
0.267 0.267 0.267 rg
26.625 364.678 132.554 0.750 re f
26.625 348.797 0.750 16.631 re f
158.429 364.678 86.186 0.750 re f
158.429 348.797 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 354.823 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 364.678 97.313 0.750 re f
243.865 348.797 0.750 16.631 re f
340.428 364.678 123.536 0.750 re f
340.428 348.797 0.750 16.631 re f
463.214 364.678 51.023 0.750 re f
463.214 348.797 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 354.823 Td /F1 9.8 Tf  [(0.621)] TJ ET
0.267 0.267 0.267 rg
513.487 364.678 67.388 0.750 re f
513.487 348.797 0.750 16.631 re f
580.125 348.797 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 354.823 Td /F1 9.8 Tf  [(0.296)] TJ ET
0.267 0.267 0.267 rg
26.625 348.797 132.554 0.750 re f
26.625 332.915 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 338.942 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 338.942 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 76.579 338.942 Td /F1 9.8 Tf  [( rs1969060)] TJ ET
0.267 0.267 0.267 rg
158.429 348.797 86.186 0.750 re f
158.429 332.915 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 338.942 Td /F1 9.8 Tf  [(TT \(n=373\))] TJ ET
0.267 0.267 0.267 rg
243.865 348.797 97.313 0.750 re f
243.865 332.915 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 338.942 Td /F1 9.8 Tf  [(44.51�3.6)] TJ ET
0.267 0.267 0.267 rg
340.428 348.797 123.536 0.750 re f
340.428 332.915 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 338.942 Td /F1 9.8 Tf  [(43.79�11.5)] TJ ET
0.267 0.267 0.267 rg
463.214 348.797 51.023 0.750 re f
463.214 332.915 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 338.942 Td /F1 9.8 Tf  [(0.620)] TJ ET
0.267 0.267 0.267 rg
513.487 348.797 67.388 0.750 re f
513.487 332.915 0.750 16.631 re f
580.125 332.915 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 338.942 Td /F1 9.8 Tf  [(0.824)] TJ ET
0.267 0.267 0.267 rg
26.625 332.915 132.554 0.750 re f
26.625 317.034 0.750 16.631 re f
158.429 332.915 86.186 0.750 re f
158.429 317.034 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 323.060 Td /F1 9.8 Tf  [(TC \(n=153\))] TJ ET
0.267 0.267 0.267 rg
243.865 332.915 97.313 0.750 re f
243.865 317.034 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 323.060 Td /F1 9.8 Tf  [(45.32�4.9)] TJ ET
0.267 0.267 0.267 rg
340.428 332.915 123.536 0.750 re f
340.428 317.034 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 323.060 Td /F1 9.8 Tf  [(42.19�11.9)] TJ ET
0.267 0.267 0.267 rg
463.214 332.915 51.023 0.750 re f
463.214 317.034 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 323.060 Td /F1 9.8 Tf  [(0.620)] TJ ET
0.267 0.267 0.267 rg
513.487 332.915 67.388 0.750 re f
513.487 317.034 0.750 16.631 re f
580.125 317.034 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 323.060 Td /F1 9.8 Tf  [(0.934)] TJ ET
0.267 0.267 0.267 rg
26.625 317.034 132.554 0.750 re f
26.625 301.153 0.750 16.631 re f
158.429 317.034 86.186 0.750 re f
158.429 301.153 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 307.179 Td /F1 9.8 Tf  [(CC \(n=12\))] TJ ET
0.267 0.267 0.267 rg
243.865 317.034 97.313 0.750 re f
243.865 301.153 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 307.179 Td /F1 9.8 Tf  [(43.75�2.5)] TJ ET
0.267 0.267 0.267 rg
340.428 317.034 123.536 0.750 re f
340.428 301.153 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 307.179 Td /F1 9.8 Tf  [(46.25�9.5)] TJ ET
0.267 0.267 0.267 rg
463.214 317.034 51.023 0.750 re f
463.214 301.153 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 307.179 Td /F1 9.8 Tf  [(0.620)] TJ ET
0.267 0.267 0.267 rg
513.487 317.034 67.388 0.750 re f
513.487 301.153 0.750 16.631 re f
580.125 301.153 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 307.179 Td /F1 9.8 Tf  [(0.658)] TJ ET
0.267 0.267 0.267 rg
26.625 301.153 132.554 0.750 re f
26.625 285.271 0.750 16.631 re f
158.429 301.153 86.186 0.750 re f
158.429 285.271 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 291.298 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 301.153 97.313 0.750 re f
243.865 285.271 0.750 16.631 re f
340.428 301.153 123.536 0.750 re f
340.428 285.271 0.750 16.631 re f
463.214 301.153 51.023 0.750 re f
463.214 285.271 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 291.298 Td /F1 9.8 Tf  [(0.620)] TJ ET
0.267 0.267 0.267 rg
513.487 301.153 67.388 0.750 re f
513.487 285.271 0.750 16.631 re f
580.125 285.271 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 291.298 Td /F1 9.8 Tf  [(0.744)] TJ ET
0.267 0.267 0.267 rg
26.625 285.271 132.554 0.750 re f
26.625 269.390 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 275.416 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 275.416 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 76.579 275.416 Td /F1 9.8 Tf  [( rs2650427)] TJ ET
0.267 0.267 0.267 rg
158.429 285.271 86.186 0.750 re f
158.429 269.390 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 275.416 Td /F1 9.8 Tf  [(CC \(n=181\))] TJ ET
0.267 0.267 0.267 rg
243.865 285.271 97.313 0.750 re f
243.865 269.390 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 275.416 Td /F1 9.8 Tf  [(44.15�3.8)] TJ ET
0.267 0.267 0.267 rg
340.428 285.271 123.536 0.750 re f
340.428 269.390 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 275.416 Td /F1 9.8 Tf  [(41.99�11.8)] TJ ET
0.267 0.267 0.267 rg
463.214 285.271 51.023 0.750 re f
463.214 269.390 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 275.416 Td /F1 9.8 Tf  [(0.620)] TJ ET
0.267 0.267 0.267 rg
513.487 285.271 67.388 0.750 re f
513.487 269.390 0.750 16.631 re f
580.125 269.390 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 275.416 Td /F1 9.8 Tf  [(0.362)] TJ ET
0.267 0.267 0.267 rg
26.625 269.390 132.554 0.750 re f
26.625 253.509 0.750 16.631 re f
158.429 269.390 86.186 0.750 re f
158.429 253.509 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 259.535 Td /F1 9.8 Tf  [(CT \(n=259\))] TJ ET
0.267 0.267 0.267 rg
243.865 269.390 97.313 0.750 re f
243.865 253.509 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 259.535 Td /F1 9.8 Tf  [(44.48�4.1)] TJ ET
0.267 0.267 0.267 rg
340.428 269.390 123.536 0.750 re f
340.428 253.509 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 259.535 Td /F1 9.8 Tf  [(44.00�11.9)] TJ ET
0.267 0.267 0.267 rg
463.214 269.390 51.023 0.750 re f
463.214 253.509 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 259.535 Td /F1 9.8 Tf  [(0.620)] TJ ET
0.267 0.267 0.267 rg
513.487 269.390 67.388 0.750 re f
513.487 253.509 0.750 16.631 re f
580.125 253.509 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 259.535 Td /F1 9.8 Tf  [(0.792)] TJ ET
0.267 0.267 0.267 rg
26.625 253.509 132.554 0.750 re f
26.625 237.628 0.750 16.631 re f
158.429 253.509 86.186 0.750 re f
158.429 237.628 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 243.654 Td /F1 9.8 Tf  [(TT \(n=98\))] TJ ET
0.267 0.267 0.267 rg
243.865 253.509 97.313 0.750 re f
243.865 237.628 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 243.654 Td /F1 9.8 Tf  [(44.60�4.2)] TJ ET
0.267 0.267 0.267 rg
340.428 253.509 123.536 0.750 re f
340.428 237.628 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 243.654 Td /F1 9.8 Tf  [(44.34�10.4)] TJ ET
0.267 0.267 0.267 rg
463.214 253.509 51.023 0.750 re f
463.214 237.628 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 243.654 Td /F1 9.8 Tf  [(0.621)] TJ ET
0.267 0.267 0.267 rg
513.487 253.509 67.388 0.750 re f
513.487 237.628 0.750 16.631 re f
580.125 237.628 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 243.654 Td /F1 9.8 Tf  [(0.143)] TJ ET
0.267 0.267 0.267 rg
26.625 237.628 132.554 0.750 re f
26.625 221.746 0.750 16.631 re f
158.429 237.628 86.186 0.750 re f
158.429 221.746 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 227.773 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 237.628 97.313 0.750 re f
243.865 221.746 0.750 16.631 re f
340.428 237.628 123.536 0.750 re f
340.428 221.746 0.750 16.631 re f
463.214 237.628 51.023 0.750 re f
463.214 221.746 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 227.773 Td /F1 9.8 Tf  [(0.621)] TJ ET
0.267 0.267 0.267 rg
513.487 237.628 67.388 0.750 re f
513.487 221.746 0.750 16.631 re f
580.125 221.746 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 227.773 Td /F1 9.8 Tf  [(0.158)] TJ ET
0.753 0.753 0.753 rg
27.000 198.609 131.804 23.512 re f
0.267 0.267 0.267 rg
26.625 221.746 132.554 0.750 re f
26.625 198.234 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 31.875 211.891 Td /F1 9.8 Tf  [(Model)] TJ ET
0.753 0.753 0.753 rg
158.804 198.609 85.436 23.512 re f
0.267 0.267 0.267 rg
158.429 221.746 86.186 0.750 re f
158.429 198.234 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 163.679 211.891 Td /F1 9.8 Tf  [(Genotypes)] TJ ET
0.753 0.753 0.753 rg
244.240 198.609 96.563 23.512 re f
0.267 0.267 0.267 rg
243.865 221.746 97.313 0.750 re f
243.865 198.234 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 249.115 211.891 Td /F1 9.8 Tf  [(CAGmean � SD)] TJ ET
0.753 0.753 0.753 rg
340.803 198.609 122.786 23.512 re f
0.267 0.267 0.267 rg
340.428 221.746 123.536 0.750 re f
340.428 198.234 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 345.678 211.891 Td /F4 9.8 Tf  [(psychiatric AO)] TJ ET
BT 414.493 211.891 Td /F1 9.8 Tf  [(mean � )] TJ ET
BT 345.678 204.260 Td /F1 9.8 Tf  [(SD)] TJ ET
0.753 0.753 0.753 rg
463.589 198.609 50.273 23.512 re f
0.267 0.267 0.267 rg
463.214 221.746 51.023 0.750 re f
463.214 198.234 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 468.464 211.891 Td /F1 9.8 Tf  [(R�*)] TJ ET
0.753 0.753 0.753 rg
513.862 198.609 66.638 23.512 re f
0.267 0.267 0.267 rg
513.487 221.746 67.388 0.750 re f
513.487 198.234 0.750 24.262 re f
580.125 198.234 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 518.737 211.891 Td /F1 9.8 Tf  [(P value)] TJ ET
0.600 0.600 0.600 rg
27.000 182.728 131.804 15.881 re f
0.267 0.267 0.267 rg
26.625 198.234 132.554 0.750 re f
26.625 182.353 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 188.379 Td /F1 9.8 Tf  [(HD CAG 40-67 \( )] TJ ET
BT 106.102 188.379 Td /F5 9.8 Tf  [(n)] TJ ET
BT 111.523 188.379 Td /F1 9.8 Tf  [( =241\))] TJ ET
0.600 0.600 0.600 rg
158.804 182.728 85.436 15.881 re f
0.267 0.267 0.267 rg
158.429 198.234 86.186 0.750 re f
158.429 182.353 0.750 16.631 re f
0.600 0.600 0.600 rg
244.240 182.728 96.563 15.881 re f
0.267 0.267 0.267 rg
243.865 198.234 97.313 0.750 re f
243.865 182.353 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 188.379 Td /F1 9.8 Tf  [(44.73�4.1)] TJ ET
0.600 0.600 0.600 rg
340.803 182.728 122.786 15.881 re f
0.267 0.267 0.267 rg
340.428 198.234 123.536 0.750 re f
340.428 182.353 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 188.379 Td /F4 9.8 Tf  [(39.86�10.8)] TJ ET
0.600 0.600 0.600 rg
463.589 182.728 50.273 15.881 re f
0.267 0.267 0.267 rg
463.214 198.234 51.023 0.750 re f
463.214 182.353 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 188.379 Td /F1 9.8 Tf  [(0.515)] TJ ET
0.600 0.600 0.600 rg
513.862 182.728 66.638 15.881 re f
0.267 0.267 0.267 rg
513.487 198.234 67.388 0.750 re f
513.487 182.353 0.750 16.631 re f
580.125 182.353 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 188.379 Td /F1 9.8 Tf  [(<0.0005)] TJ ET
0.267 0.267 0.267 rg
26.625 182.353 132.554 0.750 re f
26.625 158.840 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 31.875 172.498 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 172.498 Td /F5 9.8 Tf  [(GRIN2B)] TJ ET
BT 76.579 172.498 Td /F1 9.8 Tf  [( C2664T )] TJ ET
BT 31.875 164.866 Td /F1 9.8 Tf  [(\(rs1806201\))] TJ ET
0.267 0.267 0.267 rg
158.429 182.353 86.186 0.750 re f
158.429 158.840 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 163.679 172.498 Td /F1 9.8 Tf  [(CC \(n=139\))] TJ ET
0.267 0.267 0.267 rg
243.865 182.353 97.313 0.750 re f
243.865 158.840 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 249.115 172.498 Td /F1 9.8 Tf  [(44.81�4.4)] TJ ET
0.267 0.267 0.267 rg
340.428 182.353 123.536 0.750 re f
340.428 158.840 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 345.678 172.498 Td /F1 9.8 Tf  [(39.50�11.3)] TJ ET
0.267 0.267 0.267 rg
463.214 182.353 51.023 0.750 re f
463.214 158.840 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 468.464 172.498 Td /F1 9.8 Tf  [(0.513)] TJ ET
0.267 0.267 0.267 rg
513.487 182.353 67.388 0.750 re f
513.487 158.840 0.750 24.262 re f
580.125 158.840 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 518.737 172.498 Td /F1 9.8 Tf  [(0.964)] TJ ET
0.267 0.267 0.267 rg
26.625 158.840 132.554 0.750 re f
26.625 142.959 0.750 16.631 re f
158.429 158.840 86.186 0.750 re f
158.429 142.959 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 148.985 Td /F1 9.8 Tf  [(CT \(n=90\))] TJ ET
0.267 0.267 0.267 rg
243.865 158.840 97.313 0.750 re f
243.865 142.959 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 148.985 Td /F1 9.8 Tf  [(44.74�3.8)] TJ ET
0.267 0.267 0.267 rg
340.428 158.840 123.536 0.750 re f
340.428 142.959 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 148.985 Td /F1 9.8 Tf  [(39.79�10.5)] TJ ET
0.267 0.267 0.267 rg
463.214 158.840 51.023 0.750 re f
463.214 142.959 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 148.985 Td /F1 9.8 Tf  [(0.514)] TJ ET
0.267 0.267 0.267 rg
513.487 158.840 67.388 0.750 re f
513.487 142.959 0.750 16.631 re f
580.125 142.959 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 148.985 Td /F1 9.8 Tf  [(0.607)] TJ ET
0.267 0.267 0.267 rg
26.625 142.959 132.554 0.750 re f
26.625 127.078 0.750 16.631 re f
158.429 142.959 86.186 0.750 re f
158.429 127.078 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 133.104 Td /F1 9.8 Tf  [(TT \(n=12\))] TJ ET
0.267 0.267 0.267 rg
243.865 142.959 97.313 0.750 re f
243.865 127.078 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 133.104 Td /F1 9.8 Tf  [(43.67�2.1)] TJ ET
0.267 0.267 0.267 rg
340.428 142.959 123.536 0.750 re f
340.428 127.078 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 133.104 Td /F1 9.8 Tf  [(44.58�9.6)] TJ ET
0.267 0.267 0.267 rg
463.214 142.959 51.023 0.750 re f
463.214 127.078 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 133.104 Td /F1 9.8 Tf  [(0.517)] TJ ET
0.267 0.267 0.267 rg
513.487 142.959 67.388 0.750 re f
513.487 127.078 0.750 16.631 re f
580.125 127.078 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 133.104 Td /F1 9.8 Tf  [(0.211)] TJ ET
0.267 0.267 0.267 rg
26.625 127.078 132.554 0.750 re f
26.625 111.196 0.750 16.631 re f
158.429 127.078 86.186 0.750 re f
158.429 111.196 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 117.223 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 127.078 97.313 0.750 re f
243.865 111.196 0.750 16.631 re f
340.428 127.078 123.536 0.750 re f
340.428 111.196 0.750 16.631 re f
463.214 127.078 51.023 0.750 re f
463.214 111.196 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 117.223 Td /F1 9.8 Tf  [(0.514)] TJ ET
0.267 0.267 0.267 rg
513.487 127.078 67.388 0.750 re f
513.487 111.196 0.750 16.631 re f
580.125 111.196 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 117.223 Td /F1 9.8 Tf  [(0.618)] TJ ET
0.267 0.267 0.267 rg
26.625 111.196 132.554 0.750 re f
26.625 95.315 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 101.341 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 101.341 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 76.579 101.341 Td /F1 9.8 Tf  [( rs1969060)] TJ ET
0.267 0.267 0.267 rg
158.429 111.196 86.186 0.750 re f
158.429 95.315 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 101.341 Td /F1 9.8 Tf  [(TT \(n=172\))] TJ ET
0.267 0.267 0.267 rg
243.865 111.196 97.313 0.750 re f
243.865 95.315 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 101.341 Td /F1 9.8 Tf  [(44.79�4.1)] TJ ET
0.267 0.267 0.267 rg
340.428 111.196 123.536 0.750 re f
340.428 95.315 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 101.341 Td /F1 9.8 Tf  [(39.01�10.9)] TJ ET
0.267 0.267 0.267 rg
463.214 111.196 51.023 0.750 re f
463.214 95.315 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 101.341 Td /F4 9.8 Tf  [(0.523)] TJ ET
0.267 0.267 0.267 rg
513.487 111.196 67.388 0.750 re f
513.487 95.315 0.750 16.631 re f
580.125 95.315 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 101.341 Td /F4 9.8 Tf  [(0.026)] TJ ET
0.267 0.267 0.267 rg
26.625 95.315 132.554 0.750 re f
26.625 79.434 132.554 0.750 re f
26.625 79.434 0.750 16.631 re f
158.429 95.315 86.186 0.750 re f
158.429 79.434 86.186 0.750 re f
158.429 79.434 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 85.460 Td /F1 9.8 Tf  [(TC \(n=63\))] TJ ET
0.267 0.267 0.267 rg
243.865 95.315 97.313 0.750 re f
243.865 79.434 97.313 0.750 re f
243.865 79.434 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 85.460 Td /F1 9.8 Tf  [(44.01�3.7)] TJ ET
0.267 0.267 0.267 rg
340.428 95.315 123.536 0.750 re f
340.428 79.434 123.536 0.750 re f
340.428 79.434 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 85.460 Td /F1 9.8 Tf  [(42.78�9.8)] TJ ET
0.267 0.267 0.267 rg
463.214 95.315 51.023 0.750 re f
463.214 79.434 51.023 0.750 re f
463.214 79.434 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 85.460 Td /F4 9.8 Tf  [(0.523)] TJ ET
0.267 0.267 0.267 rg
513.487 95.315 67.388 0.750 re f
513.487 79.434 67.388 0.750 re f
513.487 79.434 0.750 16.631 re f
580.125 79.434 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 85.460 Td /F4 9.8 Tf  [(0.033)] TJ ET
Q
q
0.000 0.000 0.000 rg
BT 291.710 19.825 Td /F1 11.0 Tf  [(2)] TJ ET
BT 25.000 19.825 Td /F1 11.0 Tf  [(PLOS Currents Huntington Disease)] TJ ET

Q
endstream
endobj
137 0 obj
<< /Type /Page
/Parent 3 0 R
/Annots [ 139 0 R 141 0 R 143 0 R ]
/Contents 138 0 R
>>
endobj
138 0 obj
<<
/Length 69490 >>
stream

0.271 0.267 0.267 rg
q
15.000 37.884 577.500 739.116 re W n
1.000 1.000 1.000 rg
26.250 450.750 555.000 326.250 re f
0.267 0.267 0.267 rg
26.625 776.625 132.554 0.750 re f
26.625 760.500 0.750 16.875 re f
158.429 776.625 86.186 0.750 re f
158.429 760.500 0.750 16.875 re f
0.271 0.267 0.267 rg
BT 163.679 766.770 Td /F1 9.8 Tf  [(CC \(n=6\))] TJ ET
0.267 0.267 0.267 rg
243.865 776.625 97.313 0.750 re f
243.865 760.500 0.750 16.875 re f
0.271 0.267 0.267 rg
BT 249.115 766.770 Td /F1 9.8 Tf  [(49.50�6.8)] TJ ET
0.267 0.267 0.267 rg
340.428 776.625 123.536 0.750 re f
340.428 760.500 0.750 16.875 re f
0.271 0.267 0.267 rg
BT 345.678 766.770 Td /F1 9.8 Tf  [(33.50�15.5)] TJ ET
0.267 0.267 0.267 rg
463.214 776.625 51.023 0.750 re f
463.214 760.500 0.750 16.875 re f
0.271 0.267 0.267 rg
BT 468.464 766.770 Td /F1 9.8 Tf  [(0.514)] TJ ET
0.267 0.267 0.267 rg
513.487 776.625 67.388 0.750 re f
513.487 760.500 0.750 16.875 re f
580.125 760.500 0.750 16.875 re f
0.271 0.267 0.267 rg
BT 518.737 766.770 Td /F1 9.8 Tf  [(0.649)] TJ ET
0.267 0.267 0.267 rg
26.625 760.500 132.554 0.750 re f
26.625 744.619 0.750 16.631 re f
158.429 760.500 86.186 0.750 re f
158.429 744.619 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 750.645 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 760.500 97.313 0.750 re f
243.865 744.619 0.750 16.631 re f
340.428 760.500 123.536 0.750 re f
340.428 744.619 0.750 16.631 re f
463.214 760.500 51.023 0.750 re f
463.214 744.619 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 750.645 Td /F4 9.8 Tf  [(0.522)] TJ ET
0.267 0.267 0.267 rg
513.487 760.500 67.388 0.750 re f
513.487 744.619 0.750 16.631 re f
580.125 744.619 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 750.645 Td /F4 9.8 Tf  [(0.037)] TJ ET
0.267 0.267 0.267 rg
26.625 744.619 132.554 0.750 re f
26.625 728.737 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 734.764 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 734.764 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 76.579 734.764 Td /F1 9.8 Tf  [( rs2650427)] TJ ET
0.267 0.267 0.267 rg
158.429 744.619 86.186 0.750 re f
158.429 728.737 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 734.764 Td /F1 9.8 Tf  [(CC \(n=83\))] TJ ET
0.267 0.267 0.267 rg
243.865 744.619 97.313 0.750 re f
243.865 728.737 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 734.764 Td /F1 9.8 Tf  [(44.79�4.0)] TJ ET
0.267 0.267 0.267 rg
340.428 744.619 123.536 0.750 re f
340.428 728.737 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 734.764 Td /F1 9.8 Tf  [(39.42�11.3)] TJ ET
0.267 0.267 0.267 rg
463.214 744.619 51.023 0.750 re f
463.214 728.737 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 734.764 Td /F1 9.8 Tf  [(0.514)] TJ ET
0.267 0.267 0.267 rg
513.487 744.619 67.388 0.750 re f
513.487 728.737 0.750 16.631 re f
580.125 728.737 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 734.764 Td /F1 9.8 Tf  [(0.504)] TJ ET
0.267 0.267 0.267 rg
26.625 728.737 132.554 0.750 re f
26.625 712.856 0.750 16.631 re f
158.429 728.737 86.186 0.750 re f
158.429 712.856 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 718.883 Td /F1 9.8 Tf  [(CT \(n=120\))] TJ ET
0.267 0.267 0.267 rg
243.865 728.737 97.313 0.750 re f
243.865 712.856 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 718.883 Td /F1 9.8 Tf  [(44.24�3.8)] TJ ET
0.267 0.267 0.267 rg
340.428 728.737 123.536 0.750 re f
340.428 712.856 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 718.883 Td /F1 9.8 Tf  [(40.90�10.5)] TJ ET
0.267 0.267 0.267 rg
463.214 728.737 51.023 0.750 re f
463.214 712.856 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 718.883 Td /F1 9.8 Tf  [(0.514)] TJ ET
0.267 0.267 0.267 rg
513.487 728.737 67.388 0.750 re f
513.487 712.856 0.750 16.631 re f
580.125 712.856 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 718.883 Td /F1 9.8 Tf  [(0.702)] TJ ET
0.267 0.267 0.267 rg
26.625 712.856 132.554 0.750 re f
26.625 696.975 0.750 16.631 re f
158.429 712.856 86.186 0.750 re f
158.429 696.975 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 703.001 Td /F1 9.8 Tf  [(TT \(n=38\))] TJ ET
0.267 0.267 0.267 rg
243.865 712.856 97.313 0.750 re f
243.865 696.975 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 703.001 Td /F1 9.8 Tf  [(43.13�5.1)] TJ ET
0.267 0.267 0.267 rg
340.428 712.856 123.536 0.750 re f
340.428 696.975 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 703.001 Td /F1 9.8 Tf  [(37.53�10.8)] TJ ET
0.267 0.267 0.267 rg
463.214 712.856 51.023 0.750 re f
463.214 696.975 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 703.001 Td /F1 9.8 Tf  [(0.514)] TJ ET
0.267 0.267 0.267 rg
513.487 712.856 67.388 0.750 re f
513.487 696.975 0.750 16.631 re f
580.125 696.975 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 703.001 Td /F1 9.8 Tf  [(0.724)] TJ ET
0.267 0.267 0.267 rg
26.625 696.975 132.554 0.750 re f
26.625 681.094 0.750 16.631 re f
158.429 696.975 86.186 0.750 re f
158.429 681.094 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 687.120 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 696.975 97.313 0.750 re f
243.865 681.094 0.750 16.631 re f
340.428 696.975 123.536 0.750 re f
340.428 681.094 0.750 16.631 re f
463.214 696.975 51.023 0.750 re f
463.214 681.094 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 687.120 Td /F1 9.8 Tf  [(0.514)] TJ ET
0.267 0.267 0.267 rg
513.487 696.975 67.388 0.750 re f
513.487 681.094 0.750 16.631 re f
580.125 681.094 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 687.120 Td /F1 9.8 Tf  [(0.514)] TJ ET
0.753 0.753 0.753 rg
27.000 665.587 131.804 15.881 re f
0.267 0.267 0.267 rg
26.625 681.094 132.554 0.750 re f
26.625 665.212 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 671.239 Td /F1 9.8 Tf  [(Model)] TJ ET
0.753 0.753 0.753 rg
158.804 665.587 85.436 15.881 re f
0.267 0.267 0.267 rg
158.429 681.094 86.186 0.750 re f
158.429 665.212 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 671.239 Td /F1 9.8 Tf  [(Genotypes)] TJ ET
0.753 0.753 0.753 rg
244.240 665.587 96.563 15.881 re f
0.267 0.267 0.267 rg
243.865 681.094 97.313 0.750 re f
243.865 665.212 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 671.239 Td /F1 9.8 Tf  [(CAGmean � SD)] TJ ET
0.753 0.753 0.753 rg
340.803 665.587 122.786 15.881 re f
0.267 0.267 0.267 rg
340.428 681.094 123.536 0.750 re f
340.428 665.212 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 671.239 Td /F4 9.8 Tf  [(cognitive AO)] TJ ET
BT 405.816 671.239 Td /F1 9.8 Tf  [(mean � SD)] TJ ET
0.753 0.753 0.753 rg
463.589 665.587 50.273 15.881 re f
0.267 0.267 0.267 rg
463.214 681.094 51.023 0.750 re f
463.214 665.212 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 671.239 Td /F1 9.8 Tf  [(R�*)] TJ ET
0.753 0.753 0.753 rg
513.862 665.587 66.638 15.881 re f
0.267 0.267 0.267 rg
513.487 681.094 67.388 0.750 re f
513.487 665.212 0.750 16.631 re f
580.125 665.212 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 671.239 Td /F1 9.8 Tf  [(P value)] TJ ET
0.600 0.600 0.600 rg
27.000 649.706 131.804 15.881 re f
0.267 0.267 0.267 rg
26.625 665.213 132.554 0.750 re f
26.625 649.331 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 655.358 Td /F1 9.8 Tf  [(HD CAG 40-89 \( )] TJ ET
BT 106.102 655.358 Td /F5 9.8 Tf  [(n)] TJ ET
BT 111.523 655.358 Td /F1 9.8 Tf  [( =112\))] TJ ET
0.600 0.600 0.600 rg
158.804 649.706 85.436 15.881 re f
0.267 0.267 0.267 rg
158.429 665.213 86.186 0.750 re f
158.429 649.331 0.750 16.631 re f
0.600 0.600 0.600 rg
244.240 649.706 96.563 15.881 re f
0.267 0.267 0.267 rg
243.865 665.213 97.313 0.750 re f
243.865 649.331 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 655.358 Td /F1 9.8 Tf  [(46.34�7.8)] TJ ET
0.600 0.600 0.600 rg
340.803 649.706 122.786 15.881 re f
0.267 0.267 0.267 rg
340.428 665.213 123.536 0.750 re f
340.428 649.331 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 655.358 Td /F1 9.8 Tf  [(38.60�13.1)] TJ ET
0.600 0.600 0.600 rg
463.589 649.706 50.273 15.881 re f
0.267 0.267 0.267 rg
463.214 665.213 51.023 0.750 re f
463.214 649.331 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 655.358 Td /F1 9.8 Tf  [(0.765)] TJ ET
0.600 0.600 0.600 rg
513.862 649.706 66.638 15.881 re f
0.267 0.267 0.267 rg
513.487 665.213 67.388 0.750 re f
513.487 649.331 0.750 16.631 re f
580.125 649.331 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 655.358 Td /F1 9.8 Tf  [(<0.0005)] TJ ET
0.267 0.267 0.267 rg
26.625 649.331 132.554 0.750 re f
26.625 625.819 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 31.875 639.476 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 639.476 Td /F5 9.8 Tf  [(GRIN2B)] TJ ET
BT 76.579 639.476 Td /F1 9.8 Tf  [( C2664T )] TJ ET
BT 31.875 631.845 Td /F1 9.8 Tf  [(\(rs1806201\))] TJ ET
0.267 0.267 0.267 rg
158.429 649.331 86.186 0.750 re f
158.429 625.819 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 163.679 639.476 Td /F1 9.8 Tf  [(CC \(n=54\))] TJ ET
0.267 0.267 0.267 rg
243.865 649.331 97.313 0.750 re f
243.865 625.819 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 249.115 639.476 Td /F1 9.8 Tf  [(46.76�8.5)] TJ ET
0.267 0.267 0.267 rg
340.428 649.331 123.536 0.750 re f
340.428 625.819 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 345.678 639.476 Td /F1 9.8 Tf  [(37.89�14.2)] TJ ET
0.267 0.267 0.267 rg
463.214 649.331 51.023 0.750 re f
463.214 625.819 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 468.464 639.476 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 649.331 67.388 0.750 re f
513.487 625.819 0.750 24.262 re f
580.125 625.819 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 518.737 639.476 Td /F1 9.8 Tf  [(0.621)] TJ ET
0.267 0.267 0.267 rg
26.625 625.819 132.554 0.750 re f
26.625 609.938 0.750 16.631 re f
158.429 625.819 86.186 0.750 re f
158.429 609.938 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 615.964 Td /F1 9.8 Tf  [(CT \(n=55\))] TJ ET
0.267 0.267 0.267 rg
243.865 625.819 97.313 0.750 re f
243.865 609.938 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 615.964 Td /F1 9.8 Tf  [(45.74�7.1)] TJ ET
0.267 0.267 0.267 rg
340.428 625.819 123.536 0.750 re f
340.428 609.938 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 615.964 Td /F1 9.8 Tf  [(39.73�11.9)] TJ ET
0.267 0.267 0.267 rg
463.214 625.819 51.023 0.750 re f
463.214 609.938 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 615.964 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 625.819 67.388 0.750 re f
513.487 609.938 0.750 16.631 re f
580.125 609.938 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 615.964 Td /F1 9.8 Tf  [(0.530)] TJ ET
0.267 0.267 0.267 rg
26.625 609.938 132.554 0.750 re f
26.625 594.056 0.750 16.631 re f
158.429 609.938 86.186 0.750 re f
158.429 594.056 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 600.083 Td /F1 9.8 Tf  [(TT \(n=3\))] TJ ET
0.267 0.267 0.267 rg
243.865 609.938 97.313 0.750 re f
243.865 594.056 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 600.083 Td /F1 9.8 Tf  [(50.00�6.2)] TJ ET
0.267 0.267 0.267 rg
340.428 609.938 123.536 0.750 re f
340.428 594.056 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 600.083 Td /F1 9.8 Tf  [(30.67�14.0)] TJ ET
0.267 0.267 0.267 rg
463.214 609.938 51.023 0.750 re f
463.214 594.056 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 600.083 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 609.938 67.388 0.750 re f
513.487 594.056 0.750 16.631 re f
580.125 594.056 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 600.083 Td /F1 9.8 Tf  [(0.682)] TJ ET
0.267 0.267 0.267 rg
26.625 594.056 132.554 0.750 re f
26.625 578.175 0.750 16.631 re f
158.429 594.056 86.186 0.750 re f
158.429 578.175 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 584.201 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 594.056 97.313 0.750 re f
243.865 578.175 0.750 16.631 re f
340.428 594.056 123.536 0.750 re f
340.428 578.175 0.750 16.631 re f
463.214 594.056 51.023 0.750 re f
463.214 578.175 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 584.201 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 594.056 67.388 0.750 re f
513.487 578.175 0.750 16.631 re f
580.125 578.175 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 584.201 Td /F1 9.8 Tf  [(0.742)] TJ ET
0.267 0.267 0.267 rg
26.625 578.175 132.554 0.750 re f
26.625 562.294 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 568.320 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 568.320 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 76.579 568.320 Td /F1 9.8 Tf  [( rs1969060)] TJ ET
0.267 0.267 0.267 rg
158.429 578.175 86.186 0.750 re f
158.429 562.294 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 568.320 Td /F1 9.8 Tf  [(TT \(n=74\))] TJ ET
0.267 0.267 0.267 rg
243.865 578.175 97.313 0.750 re f
243.865 562.294 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 568.320 Td /F1 9.8 Tf  [(46.24�7.8)] TJ ET
0.267 0.267 0.267 rg
340.428 578.175 123.536 0.750 re f
340.428 562.294 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 568.320 Td /F1 9.8 Tf  [(38.95�14.1)] TJ ET
0.267 0.267 0.267 rg
463.214 578.175 51.023 0.750 re f
463.214 562.294 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 568.320 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 578.175 67.388 0.750 re f
513.487 562.294 0.750 16.631 re f
580.125 562.294 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 568.320 Td /F1 9.8 Tf  [(0.682)] TJ ET
0.267 0.267 0.267 rg
26.625 562.294 132.554 0.750 re f
26.625 546.413 0.750 16.631 re f
158.429 562.294 86.186 0.750 re f
158.429 546.413 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 552.439 Td /F1 9.8 Tf  [(TC \(n=31\))] TJ ET
0.267 0.267 0.267 rg
243.865 562.294 97.313 0.750 re f
243.865 546.413 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 552.439 Td /F1 9.8 Tf  [(46.74�8.5)] TJ ET
0.267 0.267 0.267 rg
340.428 562.294 123.536 0.750 re f
340.428 546.413 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 552.439 Td /F1 9.8 Tf  [(37.68�11.4)] TJ ET
0.267 0.267 0.267 rg
463.214 562.294 51.023 0.750 re f
463.214 546.413 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 552.439 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 562.294 67.388 0.750 re f
513.487 546.413 0.750 16.631 re f
580.125 546.413 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 552.439 Td /F1 9.8 Tf  [(0.799)] TJ ET
0.267 0.267 0.267 rg
26.625 546.413 132.554 0.750 re f
26.625 530.531 0.750 16.631 re f
158.429 546.413 86.186 0.750 re f
158.429 530.531 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 536.558 Td /F1 9.8 Tf  [(CC \(n=7\))] TJ ET
0.267 0.267 0.267 rg
243.865 546.413 97.313 0.750 re f
243.865 530.531 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 536.558 Td /F1 9.8 Tf  [(45.71�3.8)] TJ ET
0.267 0.267 0.267 rg
340.428 546.413 123.536 0.750 re f
340.428 530.531 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 536.558 Td /F1 9.8 Tf  [(39.00�10.4)] TJ ET
0.267 0.267 0.267 rg
463.214 546.413 51.023 0.750 re f
463.214 530.531 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 536.558 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 546.413 67.388 0.750 re f
513.487 530.531 0.750 16.631 re f
580.125 530.531 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 536.558 Td /F1 9.8 Tf  [(0.741)] TJ ET
0.267 0.267 0.267 rg
26.625 530.531 132.554 0.750 re f
26.625 514.650 0.750 16.631 re f
158.429 530.531 86.186 0.750 re f
158.429 514.650 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 520.676 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 530.531 97.313 0.750 re f
243.865 514.650 0.750 16.631 re f
340.428 530.531 123.536 0.750 re f
340.428 514.650 0.750 16.631 re f
463.214 530.531 51.023 0.750 re f
463.214 514.650 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 520.676 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 530.531 67.388 0.750 re f
513.487 514.650 0.750 16.631 re f
580.125 514.650 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 520.676 Td /F1 9.8 Tf  [(0.650)] TJ ET
0.267 0.267 0.267 rg
26.625 514.650 132.554 0.750 re f
26.625 498.769 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 504.795 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 504.795 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 76.579 504.795 Td /F1 9.8 Tf  [( rs2650427)] TJ ET
0.267 0.267 0.267 rg
158.429 514.650 86.186 0.750 re f
158.429 498.769 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 504.795 Td /F1 9.8 Tf  [(CC \(n=40\))] TJ ET
0.267 0.267 0.267 rg
243.865 514.650 97.313 0.750 re f
243.865 498.769 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 504.795 Td /F1 9.8 Tf  [(45.55�4.9)] TJ ET
0.267 0.267 0.267 rg
340.428 514.650 123.536 0.750 re f
340.428 498.769 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 504.795 Td /F1 9.8 Tf  [(37.80�12.4)] TJ ET
0.267 0.267 0.267 rg
463.214 514.650 51.023 0.750 re f
463.214 498.769 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 504.795 Td /F4 9.8 Tf  [(0.770)] TJ ET
0.267 0.267 0.267 rg
513.487 514.650 67.388 0.750 re f
513.487 498.769 0.750 16.631 re f
580.125 498.769 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 504.795 Td /F4 9.8 Tf  [(0.054)] TJ ET
0.267 0.267 0.267 rg
26.625 498.769 132.554 0.750 re f
26.625 482.888 0.750 16.631 re f
158.429 498.769 86.186 0.750 re f
158.429 482.888 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 488.914 Td /F1 9.8 Tf  [(CT \(n=55\))] TJ ET
0.267 0.267 0.267 rg
243.865 498.769 97.313 0.750 re f
243.865 482.888 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 488.914 Td /F1 9.8 Tf  [(47.67�10.0)] TJ ET
0.267 0.267 0.267 rg
340.428 498.769 123.536 0.750 re f
340.428 482.888 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 488.914 Td /F1 9.8 Tf  [(36.87�13.2)] TJ ET
0.267 0.267 0.267 rg
463.214 498.769 51.023 0.750 re f
463.214 482.888 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 488.914 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 498.769 67.388 0.750 re f
513.487 482.888 0.750 16.631 re f
580.125 482.888 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 488.914 Td /F1 9.8 Tf  [(0.742)] TJ ET
0.267 0.267 0.267 rg
26.625 482.888 132.554 0.750 re f
26.625 467.006 0.750 16.631 re f
158.429 482.888 86.186 0.750 re f
158.429 467.006 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 473.033 Td /F1 9.8 Tf  [(TT \(n=17\))] TJ ET
0.267 0.267 0.267 rg
243.865 482.888 97.313 0.750 re f
243.865 467.006 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 473.033 Td /F1 9.8 Tf  [(43.9�3.2)] TJ ET
0.267 0.267 0.267 rg
340.428 482.888 123.536 0.750 re f
340.428 467.006 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 473.033 Td /F1 9.8 Tf  [(46.06�12.3)] TJ ET
0.267 0.267 0.267 rg
463.214 482.888 51.023 0.750 re f
463.214 467.006 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 473.033 Td /F4 9.8 Tf  [(0.772)] TJ ET
0.267 0.267 0.267 rg
513.487 482.888 67.388 0.750 re f
513.487 467.006 0.750 16.631 re f
580.125 467.006 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 473.033 Td /F4 9.8 Tf  [(0.033)] TJ ET
0.267 0.267 0.267 rg
26.625 467.006 132.554 0.750 re f
26.625 451.125 132.554 0.750 re f
26.625 451.125 0.750 16.631 re f
158.429 467.006 86.186 0.750 re f
158.429 451.125 86.186 0.750 re f
158.429 451.125 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 457.151 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 467.006 97.313 0.750 re f
243.865 451.125 97.313 0.750 re f
243.865 451.125 0.750 16.631 re f
340.428 467.006 123.536 0.750 re f
340.428 451.125 123.536 0.750 re f
340.428 451.125 0.750 16.631 re f
463.214 467.006 51.023 0.750 re f
463.214 451.125 51.023 0.750 re f
463.214 451.125 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 457.151 Td /F4 9.8 Tf  [(0.775)] TJ ET
0.267 0.267 0.267 rg
513.487 467.006 67.388 0.750 re f
513.487 451.125 67.388 0.750 re f
513.487 451.125 0.750 16.631 re f
580.125 451.125 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 457.151 Td /F4 9.8 Tf  [(0.014)] TJ ET
BT 26.250 403.726 Td /F4 9.8 Tf  [(Table )] TJ ET
BT 54.427 403.726 Td /F4 9.8 Tf  [(1)] TJ ET
BT 59.849 403.726 Td /F1 9.8 Tf  [( The variability in AO attributable to the CAG repeat length was assessed by linear regression using the logarithmically )] TJ ET
BT 26.250 391.821 Td /F1 9.8 Tf  [(transformed AO as the dependent variable and )] TJ ET
BT 231.653 391.821 Td /F5 9.8 Tf  [(GRIN)] TJ ET
BT 256.028 391.821 Td /F1 9.8 Tf  [( genotypes as independent variables. *R )] TJ ET
BT 433.790 395.710 Td /F1 8.7 Tf  [(2)] TJ ET
BT 438.609 391.821 Td /F1 9.8 Tf  [( illustrates the relative )] TJ ET
BT 26.250 379.917 Td /F1 9.8 Tf  [(improvement of the regression model, when the genotypes are considered in addition to the CAG repeats.)] TJ ET
BT 26.250 360.512 Td /F1 9.8 Tf  [(In order to control the effect of sex-specific associations, we further analysed each combination of genotype with sex, but there )] TJ ET
BT 26.250 348.607 Td /F1 9.8 Tf  [(was no trend towards significance. Moreover, on average, psychiatric and cognitive symptoms significantly predate clinical )] TJ ET
BT 26.250 336.702 Td /F1 9.8 Tf  [(motor onset by 3.5 and 4.8 years \(p< 0.001\), thus confirming that affective and cognitive symptoms could be early )] TJ ET
BT 26.250 324.798 Td /F1 9.8 Tf  [(manifestations of neuronal dysfunction.)] TJ ET
BT 26.250 288.195 Td /F4 12.0 Tf  [(Discussion)] TJ ET
BT 26.250 268.241 Td /F1 9.8 Tf  [(Of the three polymorphisms tested, GRIN2A rs2650427 showed the most consistent evidence of replication in the EHDN )] TJ ET
BT 26.250 256.336 Td /F1 9.8 Tf  [(Registry study sample. This is in accordance with another replication study in the large set of kindreds from Venezuela, where )] TJ ET
BT 26.250 244.431 Td /F1 9.8 Tf  [(GRIN2A variation also explained a small but considerable amount of additional variance in residual AO. )] TJ ET
0.267 0.267 0.267 rg
BT 474.399 244.431 Td /F1 9.8 Tf  [([5])] TJ ET
0.271 0.267 0.267 rg
BT 26.250 225.027 Td /F1 9.8 Tf  [(Yet, the interpretation of the association of cognitve AO with the GRIN2A rs2650427 polymorphism should be considered with )] TJ ET
BT 26.250 213.122 Td /F1 9.8 Tf  [(caution since the sample size of this subgroub \(n=112\) is too small to provide the statistical power required.)] TJ ET
BT 26.250 193.717 Td /F1 9.8 Tf  [(Unfortunately, none of the SNPs associated has been validated functionally and it is most likely that the polymorphisms )] TJ ET
BT 26.250 181.812 Td /F1 9.8 Tf  [(analysed are not the functional variations, but represent markers in linkage disequilibrium with variations that modify the AO. )] TJ ET
BT 26.250 169.908 Td /F1 9.8 Tf  [(Although, synonymous SNPs like GRIN2B rs1806201 might be pathogenetically relevant via influencing mRNA splicing, protein )] TJ ET
BT 26.250 158.003 Td /F1 9.8 Tf  [(stability and structure.)] TJ ET
BT 26.250 138.598 Td /F1 9.8 Tf  [(The failure to replicate the sex-specific effect of rs1806201 suggests that the original observation may have been false positive, )] TJ ET
BT 26.250 126.693 Td /F1 9.8 Tf  [(emphasizing the need for stringent statistical thresholds. On the other hand, since linkage disequilibrium is not uniform across )] TJ ET
BT 26.250 114.789 Td /F1 9.8 Tf  [(populations, the mixed ancestry in the EHDN REGISTRY study sample could account for heterogeneous results. Inconsistent )] TJ ET
BT 26.250 102.884 Td /F1 9.8 Tf  [(results may also occur because of difficulties in exact AO definitions. The data stresses the need for precise phenotyping in )] TJ ET
BT 26.250 90.979 Td /F1 9.8 Tf  [(order to reduce heterogeneity, and to facilitate the discovery of clinically relevant biological pathways.)] TJ ET
Q
q
15.000 37.884 577.500 739.116 re W n
1.000 1.000 1.000 rg
26.250 450.750 555.000 326.250 re f
0.267 0.267 0.267 rg
26.625 776.625 132.554 0.750 re f
26.625 760.500 0.750 16.875 re f
158.429 776.625 86.186 0.750 re f
158.429 760.500 0.750 16.875 re f
0.271 0.267 0.267 rg
BT 163.679 766.770 Td /F1 9.8 Tf  [(CC \(n=6\))] TJ ET
0.267 0.267 0.267 rg
243.865 776.625 97.313 0.750 re f
243.865 760.500 0.750 16.875 re f
0.271 0.267 0.267 rg
BT 249.115 766.770 Td /F1 9.8 Tf  [(49.50�6.8)] TJ ET
0.267 0.267 0.267 rg
340.428 776.625 123.536 0.750 re f
340.428 760.500 0.750 16.875 re f
0.271 0.267 0.267 rg
BT 345.678 766.770 Td /F1 9.8 Tf  [(33.50�15.5)] TJ ET
0.267 0.267 0.267 rg
463.214 776.625 51.023 0.750 re f
463.214 760.500 0.750 16.875 re f
0.271 0.267 0.267 rg
BT 468.464 766.770 Td /F1 9.8 Tf  [(0.514)] TJ ET
0.267 0.267 0.267 rg
513.487 776.625 67.388 0.750 re f
513.487 760.500 0.750 16.875 re f
580.125 760.500 0.750 16.875 re f
0.271 0.267 0.267 rg
BT 518.737 766.770 Td /F1 9.8 Tf  [(0.649)] TJ ET
0.267 0.267 0.267 rg
26.625 760.500 132.554 0.750 re f
26.625 744.619 0.750 16.631 re f
158.429 760.500 86.186 0.750 re f
158.429 744.619 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 750.645 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 760.500 97.313 0.750 re f
243.865 744.619 0.750 16.631 re f
340.428 760.500 123.536 0.750 re f
340.428 744.619 0.750 16.631 re f
463.214 760.500 51.023 0.750 re f
463.214 744.619 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 750.645 Td /F4 9.8 Tf  [(0.522)] TJ ET
0.267 0.267 0.267 rg
513.487 760.500 67.388 0.750 re f
513.487 744.619 0.750 16.631 re f
580.125 744.619 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 750.645 Td /F4 9.8 Tf  [(0.037)] TJ ET
0.267 0.267 0.267 rg
26.625 744.619 132.554 0.750 re f
26.625 728.737 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 734.764 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 734.764 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 76.579 734.764 Td /F1 9.8 Tf  [( rs2650427)] TJ ET
0.267 0.267 0.267 rg
158.429 744.619 86.186 0.750 re f
158.429 728.737 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 734.764 Td /F1 9.8 Tf  [(CC \(n=83\))] TJ ET
0.267 0.267 0.267 rg
243.865 744.619 97.313 0.750 re f
243.865 728.737 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 734.764 Td /F1 9.8 Tf  [(44.79�4.0)] TJ ET
0.267 0.267 0.267 rg
340.428 744.619 123.536 0.750 re f
340.428 728.737 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 734.764 Td /F1 9.8 Tf  [(39.42�11.3)] TJ ET
0.267 0.267 0.267 rg
463.214 744.619 51.023 0.750 re f
463.214 728.737 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 734.764 Td /F1 9.8 Tf  [(0.514)] TJ ET
0.267 0.267 0.267 rg
513.487 744.619 67.388 0.750 re f
513.487 728.737 0.750 16.631 re f
580.125 728.737 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 734.764 Td /F1 9.8 Tf  [(0.504)] TJ ET
0.267 0.267 0.267 rg
26.625 728.737 132.554 0.750 re f
26.625 712.856 0.750 16.631 re f
158.429 728.737 86.186 0.750 re f
158.429 712.856 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 718.883 Td /F1 9.8 Tf  [(CT \(n=120\))] TJ ET
0.267 0.267 0.267 rg
243.865 728.737 97.313 0.750 re f
243.865 712.856 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 718.883 Td /F1 9.8 Tf  [(44.24�3.8)] TJ ET
0.267 0.267 0.267 rg
340.428 728.737 123.536 0.750 re f
340.428 712.856 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 718.883 Td /F1 9.8 Tf  [(40.90�10.5)] TJ ET
0.267 0.267 0.267 rg
463.214 728.737 51.023 0.750 re f
463.214 712.856 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 718.883 Td /F1 9.8 Tf  [(0.514)] TJ ET
0.267 0.267 0.267 rg
513.487 728.737 67.388 0.750 re f
513.487 712.856 0.750 16.631 re f
580.125 712.856 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 718.883 Td /F1 9.8 Tf  [(0.702)] TJ ET
0.267 0.267 0.267 rg
26.625 712.856 132.554 0.750 re f
26.625 696.975 0.750 16.631 re f
158.429 712.856 86.186 0.750 re f
158.429 696.975 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 703.001 Td /F1 9.8 Tf  [(TT \(n=38\))] TJ ET
0.267 0.267 0.267 rg
243.865 712.856 97.313 0.750 re f
243.865 696.975 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 703.001 Td /F1 9.8 Tf  [(43.13�5.1)] TJ ET
0.267 0.267 0.267 rg
340.428 712.856 123.536 0.750 re f
340.428 696.975 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 703.001 Td /F1 9.8 Tf  [(37.53�10.8)] TJ ET
0.267 0.267 0.267 rg
463.214 712.856 51.023 0.750 re f
463.214 696.975 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 703.001 Td /F1 9.8 Tf  [(0.514)] TJ ET
0.267 0.267 0.267 rg
513.487 712.856 67.388 0.750 re f
513.487 696.975 0.750 16.631 re f
580.125 696.975 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 703.001 Td /F1 9.8 Tf  [(0.724)] TJ ET
0.267 0.267 0.267 rg
26.625 696.975 132.554 0.750 re f
26.625 681.094 0.750 16.631 re f
158.429 696.975 86.186 0.750 re f
158.429 681.094 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 687.120 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 696.975 97.313 0.750 re f
243.865 681.094 0.750 16.631 re f
340.428 696.975 123.536 0.750 re f
340.428 681.094 0.750 16.631 re f
463.214 696.975 51.023 0.750 re f
463.214 681.094 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 687.120 Td /F1 9.8 Tf  [(0.514)] TJ ET
0.267 0.267 0.267 rg
513.487 696.975 67.388 0.750 re f
513.487 681.094 0.750 16.631 re f
580.125 681.094 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 687.120 Td /F1 9.8 Tf  [(0.514)] TJ ET
0.753 0.753 0.753 rg
27.000 665.587 131.804 15.881 re f
0.267 0.267 0.267 rg
26.625 681.094 132.554 0.750 re f
26.625 665.212 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 671.239 Td /F1 9.8 Tf  [(Model)] TJ ET
0.753 0.753 0.753 rg
158.804 665.587 85.436 15.881 re f
0.267 0.267 0.267 rg
158.429 681.094 86.186 0.750 re f
158.429 665.212 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 671.239 Td /F1 9.8 Tf  [(Genotypes)] TJ ET
0.753 0.753 0.753 rg
244.240 665.587 96.563 15.881 re f
0.267 0.267 0.267 rg
243.865 681.094 97.313 0.750 re f
243.865 665.212 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 671.239 Td /F1 9.8 Tf  [(CAGmean � SD)] TJ ET
0.753 0.753 0.753 rg
340.803 665.587 122.786 15.881 re f
0.267 0.267 0.267 rg
340.428 681.094 123.536 0.750 re f
340.428 665.212 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 671.239 Td /F4 9.8 Tf  [(cognitive AO)] TJ ET
BT 405.816 671.239 Td /F1 9.8 Tf  [(mean � SD)] TJ ET
0.753 0.753 0.753 rg
463.589 665.587 50.273 15.881 re f
0.267 0.267 0.267 rg
463.214 681.094 51.023 0.750 re f
463.214 665.212 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 671.239 Td /F1 9.8 Tf  [(R�*)] TJ ET
0.753 0.753 0.753 rg
513.862 665.587 66.638 15.881 re f
0.267 0.267 0.267 rg
513.487 681.094 67.388 0.750 re f
513.487 665.212 0.750 16.631 re f
580.125 665.212 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 671.239 Td /F1 9.8 Tf  [(P value)] TJ ET
0.600 0.600 0.600 rg
27.000 649.706 131.804 15.881 re f
0.267 0.267 0.267 rg
26.625 665.213 132.554 0.750 re f
26.625 649.331 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 655.358 Td /F1 9.8 Tf  [(HD CAG 40-89 \( )] TJ ET
BT 106.102 655.358 Td /F5 9.8 Tf  [(n)] TJ ET
BT 111.523 655.358 Td /F1 9.8 Tf  [( =112\))] TJ ET
0.600 0.600 0.600 rg
158.804 649.706 85.436 15.881 re f
0.267 0.267 0.267 rg
158.429 665.213 86.186 0.750 re f
158.429 649.331 0.750 16.631 re f
0.600 0.600 0.600 rg
244.240 649.706 96.563 15.881 re f
0.267 0.267 0.267 rg
243.865 665.213 97.313 0.750 re f
243.865 649.331 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 655.358 Td /F1 9.8 Tf  [(46.34�7.8)] TJ ET
0.600 0.600 0.600 rg
340.803 649.706 122.786 15.881 re f
0.267 0.267 0.267 rg
340.428 665.213 123.536 0.750 re f
340.428 649.331 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 655.358 Td /F1 9.8 Tf  [(38.60�13.1)] TJ ET
0.600 0.600 0.600 rg
463.589 649.706 50.273 15.881 re f
0.267 0.267 0.267 rg
463.214 665.213 51.023 0.750 re f
463.214 649.331 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 655.358 Td /F1 9.8 Tf  [(0.765)] TJ ET
0.600 0.600 0.600 rg
513.862 649.706 66.638 15.881 re f
0.267 0.267 0.267 rg
513.487 665.213 67.388 0.750 re f
513.487 649.331 0.750 16.631 re f
580.125 649.331 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 655.358 Td /F1 9.8 Tf  [(<0.0005)] TJ ET
0.267 0.267 0.267 rg
26.625 649.331 132.554 0.750 re f
26.625 625.819 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 31.875 639.476 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 639.476 Td /F5 9.8 Tf  [(GRIN2B)] TJ ET
BT 76.579 639.476 Td /F1 9.8 Tf  [( C2664T )] TJ ET
BT 31.875 631.845 Td /F1 9.8 Tf  [(\(rs1806201\))] TJ ET
0.267 0.267 0.267 rg
158.429 649.331 86.186 0.750 re f
158.429 625.819 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 163.679 639.476 Td /F1 9.8 Tf  [(CC \(n=54\))] TJ ET
0.267 0.267 0.267 rg
243.865 649.331 97.313 0.750 re f
243.865 625.819 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 249.115 639.476 Td /F1 9.8 Tf  [(46.76�8.5)] TJ ET
0.267 0.267 0.267 rg
340.428 649.331 123.536 0.750 re f
340.428 625.819 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 345.678 639.476 Td /F1 9.8 Tf  [(37.89�14.2)] TJ ET
0.267 0.267 0.267 rg
463.214 649.331 51.023 0.750 re f
463.214 625.819 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 468.464 639.476 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 649.331 67.388 0.750 re f
513.487 625.819 0.750 24.262 re f
580.125 625.819 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 518.737 639.476 Td /F1 9.8 Tf  [(0.621)] TJ ET
0.267 0.267 0.267 rg
26.625 625.819 132.554 0.750 re f
26.625 609.938 0.750 16.631 re f
158.429 625.819 86.186 0.750 re f
158.429 609.938 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 615.964 Td /F1 9.8 Tf  [(CT \(n=55\))] TJ ET
0.267 0.267 0.267 rg
243.865 625.819 97.313 0.750 re f
243.865 609.938 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 615.964 Td /F1 9.8 Tf  [(45.74�7.1)] TJ ET
0.267 0.267 0.267 rg
340.428 625.819 123.536 0.750 re f
340.428 609.938 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 615.964 Td /F1 9.8 Tf  [(39.73�11.9)] TJ ET
0.267 0.267 0.267 rg
463.214 625.819 51.023 0.750 re f
463.214 609.938 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 615.964 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 625.819 67.388 0.750 re f
513.487 609.938 0.750 16.631 re f
580.125 609.938 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 615.964 Td /F1 9.8 Tf  [(0.530)] TJ ET
0.267 0.267 0.267 rg
26.625 609.938 132.554 0.750 re f
26.625 594.056 0.750 16.631 re f
158.429 609.938 86.186 0.750 re f
158.429 594.056 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 600.083 Td /F1 9.8 Tf  [(TT \(n=3\))] TJ ET
0.267 0.267 0.267 rg
243.865 609.938 97.313 0.750 re f
243.865 594.056 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 600.083 Td /F1 9.8 Tf  [(50.00�6.2)] TJ ET
0.267 0.267 0.267 rg
340.428 609.938 123.536 0.750 re f
340.428 594.056 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 600.083 Td /F1 9.8 Tf  [(30.67�14.0)] TJ ET
0.267 0.267 0.267 rg
463.214 609.938 51.023 0.750 re f
463.214 594.056 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 600.083 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 609.938 67.388 0.750 re f
513.487 594.056 0.750 16.631 re f
580.125 594.056 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 600.083 Td /F1 9.8 Tf  [(0.682)] TJ ET
0.267 0.267 0.267 rg
26.625 594.056 132.554 0.750 re f
26.625 578.175 0.750 16.631 re f
158.429 594.056 86.186 0.750 re f
158.429 578.175 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 584.201 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 594.056 97.313 0.750 re f
243.865 578.175 0.750 16.631 re f
340.428 594.056 123.536 0.750 re f
340.428 578.175 0.750 16.631 re f
463.214 594.056 51.023 0.750 re f
463.214 578.175 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 584.201 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 594.056 67.388 0.750 re f
513.487 578.175 0.750 16.631 re f
580.125 578.175 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 584.201 Td /F1 9.8 Tf  [(0.742)] TJ ET
0.267 0.267 0.267 rg
26.625 578.175 132.554 0.750 re f
26.625 562.294 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 568.320 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 568.320 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 76.579 568.320 Td /F1 9.8 Tf  [( rs1969060)] TJ ET
0.267 0.267 0.267 rg
158.429 578.175 86.186 0.750 re f
158.429 562.294 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 568.320 Td /F1 9.8 Tf  [(TT \(n=74\))] TJ ET
0.267 0.267 0.267 rg
243.865 578.175 97.313 0.750 re f
243.865 562.294 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 568.320 Td /F1 9.8 Tf  [(46.24�7.8)] TJ ET
0.267 0.267 0.267 rg
340.428 578.175 123.536 0.750 re f
340.428 562.294 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 568.320 Td /F1 9.8 Tf  [(38.95�14.1)] TJ ET
0.267 0.267 0.267 rg
463.214 578.175 51.023 0.750 re f
463.214 562.294 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 568.320 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 578.175 67.388 0.750 re f
513.487 562.294 0.750 16.631 re f
580.125 562.294 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 568.320 Td /F1 9.8 Tf  [(0.682)] TJ ET
0.267 0.267 0.267 rg
26.625 562.294 132.554 0.750 re f
26.625 546.413 0.750 16.631 re f
158.429 562.294 86.186 0.750 re f
158.429 546.413 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 552.439 Td /F1 9.8 Tf  [(TC \(n=31\))] TJ ET
0.267 0.267 0.267 rg
243.865 562.294 97.313 0.750 re f
243.865 546.413 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 552.439 Td /F1 9.8 Tf  [(46.74�8.5)] TJ ET
0.267 0.267 0.267 rg
340.428 562.294 123.536 0.750 re f
340.428 546.413 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 552.439 Td /F1 9.8 Tf  [(37.68�11.4)] TJ ET
0.267 0.267 0.267 rg
463.214 562.294 51.023 0.750 re f
463.214 546.413 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 552.439 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 562.294 67.388 0.750 re f
513.487 546.413 0.750 16.631 re f
580.125 546.413 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 552.439 Td /F1 9.8 Tf  [(0.799)] TJ ET
0.267 0.267 0.267 rg
26.625 546.413 132.554 0.750 re f
26.625 530.531 0.750 16.631 re f
158.429 546.413 86.186 0.750 re f
158.429 530.531 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 536.558 Td /F1 9.8 Tf  [(CC \(n=7\))] TJ ET
0.267 0.267 0.267 rg
243.865 546.413 97.313 0.750 re f
243.865 530.531 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 536.558 Td /F1 9.8 Tf  [(45.71�3.8)] TJ ET
0.267 0.267 0.267 rg
340.428 546.413 123.536 0.750 re f
340.428 530.531 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 536.558 Td /F1 9.8 Tf  [(39.00�10.4)] TJ ET
0.267 0.267 0.267 rg
463.214 546.413 51.023 0.750 re f
463.214 530.531 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 536.558 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 546.413 67.388 0.750 re f
513.487 530.531 0.750 16.631 re f
580.125 530.531 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 536.558 Td /F1 9.8 Tf  [(0.741)] TJ ET
0.267 0.267 0.267 rg
26.625 530.531 132.554 0.750 re f
26.625 514.650 0.750 16.631 re f
158.429 530.531 86.186 0.750 re f
158.429 514.650 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 520.676 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 530.531 97.313 0.750 re f
243.865 514.650 0.750 16.631 re f
340.428 530.531 123.536 0.750 re f
340.428 514.650 0.750 16.631 re f
463.214 530.531 51.023 0.750 re f
463.214 514.650 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 520.676 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 530.531 67.388 0.750 re f
513.487 514.650 0.750 16.631 re f
580.125 514.650 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 520.676 Td /F1 9.8 Tf  [(0.650)] TJ ET
0.267 0.267 0.267 rg
26.625 514.650 132.554 0.750 re f
26.625 498.769 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 504.795 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 504.795 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 76.579 504.795 Td /F1 9.8 Tf  [( rs2650427)] TJ ET
0.267 0.267 0.267 rg
158.429 514.650 86.186 0.750 re f
158.429 498.769 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 504.795 Td /F1 9.8 Tf  [(CC \(n=40\))] TJ ET
0.267 0.267 0.267 rg
243.865 514.650 97.313 0.750 re f
243.865 498.769 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 504.795 Td /F1 9.8 Tf  [(45.55�4.9)] TJ ET
0.267 0.267 0.267 rg
340.428 514.650 123.536 0.750 re f
340.428 498.769 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 504.795 Td /F1 9.8 Tf  [(37.80�12.4)] TJ ET
0.267 0.267 0.267 rg
463.214 514.650 51.023 0.750 re f
463.214 498.769 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 504.795 Td /F4 9.8 Tf  [(0.770)] TJ ET
0.267 0.267 0.267 rg
513.487 514.650 67.388 0.750 re f
513.487 498.769 0.750 16.631 re f
580.125 498.769 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 504.795 Td /F4 9.8 Tf  [(0.054)] TJ ET
0.267 0.267 0.267 rg
26.625 498.769 132.554 0.750 re f
26.625 482.888 0.750 16.631 re f
158.429 498.769 86.186 0.750 re f
158.429 482.888 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 488.914 Td /F1 9.8 Tf  [(CT \(n=55\))] TJ ET
0.267 0.267 0.267 rg
243.865 498.769 97.313 0.750 re f
243.865 482.888 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 488.914 Td /F1 9.8 Tf  [(47.67�10.0)] TJ ET
0.267 0.267 0.267 rg
340.428 498.769 123.536 0.750 re f
340.428 482.888 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 488.914 Td /F1 9.8 Tf  [(36.87�13.2)] TJ ET
0.267 0.267 0.267 rg
463.214 498.769 51.023 0.750 re f
463.214 482.888 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 488.914 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 498.769 67.388 0.750 re f
513.487 482.888 0.750 16.631 re f
580.125 482.888 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 488.914 Td /F1 9.8 Tf  [(0.742)] TJ ET
0.267 0.267 0.267 rg
26.625 482.888 132.554 0.750 re f
26.625 467.006 0.750 16.631 re f
158.429 482.888 86.186 0.750 re f
158.429 467.006 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 473.033 Td /F1 9.8 Tf  [(TT \(n=17\))] TJ ET
0.267 0.267 0.267 rg
243.865 482.888 97.313 0.750 re f
243.865 467.006 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 473.033 Td /F1 9.8 Tf  [(43.9�3.2)] TJ ET
0.267 0.267 0.267 rg
340.428 482.888 123.536 0.750 re f
340.428 467.006 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 473.033 Td /F1 9.8 Tf  [(46.06�12.3)] TJ ET
0.267 0.267 0.267 rg
463.214 482.888 51.023 0.750 re f
463.214 467.006 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 473.033 Td /F4 9.8 Tf  [(0.772)] TJ ET
0.267 0.267 0.267 rg
513.487 482.888 67.388 0.750 re f
513.487 467.006 0.750 16.631 re f
580.125 467.006 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 473.033 Td /F4 9.8 Tf  [(0.033)] TJ ET
0.267 0.267 0.267 rg
26.625 467.006 132.554 0.750 re f
26.625 451.125 132.554 0.750 re f
26.625 451.125 0.750 16.631 re f
158.429 467.006 86.186 0.750 re f
158.429 451.125 86.186 0.750 re f
158.429 451.125 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 457.151 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 467.006 97.313 0.750 re f
243.865 451.125 97.313 0.750 re f
243.865 451.125 0.750 16.631 re f
340.428 467.006 123.536 0.750 re f
340.428 451.125 123.536 0.750 re f
340.428 451.125 0.750 16.631 re f
463.214 467.006 51.023 0.750 re f
463.214 451.125 51.023 0.750 re f
463.214 451.125 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 457.151 Td /F4 9.8 Tf  [(0.775)] TJ ET
0.267 0.267 0.267 rg
513.487 467.006 67.388 0.750 re f
513.487 451.125 67.388 0.750 re f
513.487 451.125 0.750 16.631 re f
580.125 451.125 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 457.151 Td /F4 9.8 Tf  [(0.014)] TJ ET
BT 26.250 403.726 Td /F4 9.8 Tf  [(Table )] TJ ET
BT 54.427 403.726 Td /F4 9.8 Tf  [(1)] TJ ET
BT 59.849 403.726 Td /F1 9.8 Tf  [( The variability in AO attributable to the CAG repeat length was assessed by linear regression using the logarithmically )] TJ ET
BT 26.250 391.821 Td /F1 9.8 Tf  [(transformed AO as the dependent variable and )] TJ ET
BT 231.653 391.821 Td /F5 9.8 Tf  [(GRIN)] TJ ET
BT 256.028 391.821 Td /F1 9.8 Tf  [( genotypes as independent variables. *R )] TJ ET
BT 433.790 395.710 Td /F1 8.7 Tf  [(2)] TJ ET
BT 438.609 391.821 Td /F1 9.8 Tf  [( illustrates the relative )] TJ ET
BT 26.250 379.917 Td /F1 9.8 Tf  [(improvement of the regression model, when the genotypes are considered in addition to the CAG repeats.)] TJ ET
BT 26.250 360.512 Td /F1 9.8 Tf  [(In order to control the effect of sex-specific associations, we further analysed each combination of genotype with sex, but there )] TJ ET
BT 26.250 348.607 Td /F1 9.8 Tf  [(was no trend towards significance. Moreover, on average, psychiatric and cognitive symptoms significantly predate clinical )] TJ ET
BT 26.250 336.702 Td /F1 9.8 Tf  [(motor onset by 3.5 and 4.8 years \(p< 0.001\), thus confirming that affective and cognitive symptoms could be early )] TJ ET
BT 26.250 324.798 Td /F1 9.8 Tf  [(manifestations of neuronal dysfunction.)] TJ ET
BT 26.250 288.195 Td /F4 12.0 Tf  [(Discussion)] TJ ET
BT 26.250 268.241 Td /F1 9.8 Tf  [(Of the three polymorphisms tested, GRIN2A rs2650427 showed the most consistent evidence of replication in the EHDN )] TJ ET
BT 26.250 256.336 Td /F1 9.8 Tf  [(Registry study sample. This is in accordance with another replication study in the large set of kindreds from Venezuela, where )] TJ ET
BT 26.250 244.431 Td /F1 9.8 Tf  [(GRIN2A variation also explained a small but considerable amount of additional variance in residual AO. )] TJ ET
0.267 0.267 0.267 rg
BT 474.399 244.431 Td /F1 9.8 Tf  [([5])] TJ ET
0.271 0.267 0.267 rg
BT 26.250 225.027 Td /F1 9.8 Tf  [(Yet, the interpretation of the association of cognitve AO with the GRIN2A rs2650427 polymorphism should be considered with )] TJ ET
BT 26.250 213.122 Td /F1 9.8 Tf  [(caution since the sample size of this subgroub \(n=112\) is too small to provide the statistical power required.)] TJ ET
BT 26.250 193.717 Td /F1 9.8 Tf  [(Unfortunately, none of the SNPs associated has been validated functionally and it is most likely that the polymorphisms )] TJ ET
BT 26.250 181.812 Td /F1 9.8 Tf  [(analysed are not the functional variations, but represent markers in linkage disequilibrium with variations that modify the AO. )] TJ ET
BT 26.250 169.908 Td /F1 9.8 Tf  [(Although, synonymous SNPs like GRIN2B rs1806201 might be pathogenetically relevant via influencing mRNA splicing, protein )] TJ ET
BT 26.250 158.003 Td /F1 9.8 Tf  [(stability and structure.)] TJ ET
BT 26.250 138.598 Td /F1 9.8 Tf  [(The failure to replicate the sex-specific effect of rs1806201 suggests that the original observation may have been false positive, )] TJ ET
BT 26.250 126.693 Td /F1 9.8 Tf  [(emphasizing the need for stringent statistical thresholds. On the other hand, since linkage disequilibrium is not uniform across )] TJ ET
BT 26.250 114.789 Td /F1 9.8 Tf  [(populations, the mixed ancestry in the EHDN REGISTRY study sample could account for heterogeneous results. Inconsistent )] TJ ET
BT 26.250 102.884 Td /F1 9.8 Tf  [(results may also occur because of difficulties in exact AO definitions. The data stresses the need for precise phenotyping in )] TJ ET
BT 26.250 90.979 Td /F1 9.8 Tf  [(order to reduce heterogeneity, and to facilitate the discovery of clinically relevant biological pathways.)] TJ ET
Q
q
15.000 37.884 577.500 739.116 re W n
1.000 1.000 1.000 rg
26.250 450.750 555.000 326.250 re f
0.267 0.267 0.267 rg
26.625 776.625 132.554 0.750 re f
26.625 760.500 0.750 16.875 re f
158.429 776.625 86.186 0.750 re f
158.429 760.500 0.750 16.875 re f
0.271 0.267 0.267 rg
BT 163.679 766.770 Td /F1 9.8 Tf  [(CC \(n=6\))] TJ ET
0.267 0.267 0.267 rg
243.865 776.625 97.313 0.750 re f
243.865 760.500 0.750 16.875 re f
0.271 0.267 0.267 rg
BT 249.115 766.770 Td /F1 9.8 Tf  [(49.50�6.8)] TJ ET
0.267 0.267 0.267 rg
340.428 776.625 123.536 0.750 re f
340.428 760.500 0.750 16.875 re f
0.271 0.267 0.267 rg
BT 345.678 766.770 Td /F1 9.8 Tf  [(33.50�15.5)] TJ ET
0.267 0.267 0.267 rg
463.214 776.625 51.023 0.750 re f
463.214 760.500 0.750 16.875 re f
0.271 0.267 0.267 rg
BT 468.464 766.770 Td /F1 9.8 Tf  [(0.514)] TJ ET
0.267 0.267 0.267 rg
513.487 776.625 67.388 0.750 re f
513.487 760.500 0.750 16.875 re f
580.125 760.500 0.750 16.875 re f
0.271 0.267 0.267 rg
BT 518.737 766.770 Td /F1 9.8 Tf  [(0.649)] TJ ET
0.267 0.267 0.267 rg
26.625 760.500 132.554 0.750 re f
26.625 744.619 0.750 16.631 re f
158.429 760.500 86.186 0.750 re f
158.429 744.619 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 750.645 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 760.500 97.313 0.750 re f
243.865 744.619 0.750 16.631 re f
340.428 760.500 123.536 0.750 re f
340.428 744.619 0.750 16.631 re f
463.214 760.500 51.023 0.750 re f
463.214 744.619 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 750.645 Td /F4 9.8 Tf  [(0.522)] TJ ET
0.267 0.267 0.267 rg
513.487 760.500 67.388 0.750 re f
513.487 744.619 0.750 16.631 re f
580.125 744.619 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 750.645 Td /F4 9.8 Tf  [(0.037)] TJ ET
0.267 0.267 0.267 rg
26.625 744.619 132.554 0.750 re f
26.625 728.737 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 734.764 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 734.764 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 76.579 734.764 Td /F1 9.8 Tf  [( rs2650427)] TJ ET
0.267 0.267 0.267 rg
158.429 744.619 86.186 0.750 re f
158.429 728.737 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 734.764 Td /F1 9.8 Tf  [(CC \(n=83\))] TJ ET
0.267 0.267 0.267 rg
243.865 744.619 97.313 0.750 re f
243.865 728.737 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 734.764 Td /F1 9.8 Tf  [(44.79�4.0)] TJ ET
0.267 0.267 0.267 rg
340.428 744.619 123.536 0.750 re f
340.428 728.737 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 734.764 Td /F1 9.8 Tf  [(39.42�11.3)] TJ ET
0.267 0.267 0.267 rg
463.214 744.619 51.023 0.750 re f
463.214 728.737 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 734.764 Td /F1 9.8 Tf  [(0.514)] TJ ET
0.267 0.267 0.267 rg
513.487 744.619 67.388 0.750 re f
513.487 728.737 0.750 16.631 re f
580.125 728.737 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 734.764 Td /F1 9.8 Tf  [(0.504)] TJ ET
0.267 0.267 0.267 rg
26.625 728.737 132.554 0.750 re f
26.625 712.856 0.750 16.631 re f
158.429 728.737 86.186 0.750 re f
158.429 712.856 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 718.883 Td /F1 9.8 Tf  [(CT \(n=120\))] TJ ET
0.267 0.267 0.267 rg
243.865 728.737 97.313 0.750 re f
243.865 712.856 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 718.883 Td /F1 9.8 Tf  [(44.24�3.8)] TJ ET
0.267 0.267 0.267 rg
340.428 728.737 123.536 0.750 re f
340.428 712.856 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 718.883 Td /F1 9.8 Tf  [(40.90�10.5)] TJ ET
0.267 0.267 0.267 rg
463.214 728.737 51.023 0.750 re f
463.214 712.856 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 718.883 Td /F1 9.8 Tf  [(0.514)] TJ ET
0.267 0.267 0.267 rg
513.487 728.737 67.388 0.750 re f
513.487 712.856 0.750 16.631 re f
580.125 712.856 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 718.883 Td /F1 9.8 Tf  [(0.702)] TJ ET
0.267 0.267 0.267 rg
26.625 712.856 132.554 0.750 re f
26.625 696.975 0.750 16.631 re f
158.429 712.856 86.186 0.750 re f
158.429 696.975 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 703.001 Td /F1 9.8 Tf  [(TT \(n=38\))] TJ ET
0.267 0.267 0.267 rg
243.865 712.856 97.313 0.750 re f
243.865 696.975 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 703.001 Td /F1 9.8 Tf  [(43.13�5.1)] TJ ET
0.267 0.267 0.267 rg
340.428 712.856 123.536 0.750 re f
340.428 696.975 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 703.001 Td /F1 9.8 Tf  [(37.53�10.8)] TJ ET
0.267 0.267 0.267 rg
463.214 712.856 51.023 0.750 re f
463.214 696.975 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 703.001 Td /F1 9.8 Tf  [(0.514)] TJ ET
0.267 0.267 0.267 rg
513.487 712.856 67.388 0.750 re f
513.487 696.975 0.750 16.631 re f
580.125 696.975 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 703.001 Td /F1 9.8 Tf  [(0.724)] TJ ET
0.267 0.267 0.267 rg
26.625 696.975 132.554 0.750 re f
26.625 681.094 0.750 16.631 re f
158.429 696.975 86.186 0.750 re f
158.429 681.094 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 687.120 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 696.975 97.313 0.750 re f
243.865 681.094 0.750 16.631 re f
340.428 696.975 123.536 0.750 re f
340.428 681.094 0.750 16.631 re f
463.214 696.975 51.023 0.750 re f
463.214 681.094 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 687.120 Td /F1 9.8 Tf  [(0.514)] TJ ET
0.267 0.267 0.267 rg
513.487 696.975 67.388 0.750 re f
513.487 681.094 0.750 16.631 re f
580.125 681.094 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 687.120 Td /F1 9.8 Tf  [(0.514)] TJ ET
0.753 0.753 0.753 rg
27.000 665.587 131.804 15.881 re f
0.267 0.267 0.267 rg
26.625 681.094 132.554 0.750 re f
26.625 665.212 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 671.239 Td /F1 9.8 Tf  [(Model)] TJ ET
0.753 0.753 0.753 rg
158.804 665.587 85.436 15.881 re f
0.267 0.267 0.267 rg
158.429 681.094 86.186 0.750 re f
158.429 665.212 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 671.239 Td /F1 9.8 Tf  [(Genotypes)] TJ ET
0.753 0.753 0.753 rg
244.240 665.587 96.563 15.881 re f
0.267 0.267 0.267 rg
243.865 681.094 97.313 0.750 re f
243.865 665.212 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 671.239 Td /F1 9.8 Tf  [(CAGmean � SD)] TJ ET
0.753 0.753 0.753 rg
340.803 665.587 122.786 15.881 re f
0.267 0.267 0.267 rg
340.428 681.094 123.536 0.750 re f
340.428 665.212 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 671.239 Td /F4 9.8 Tf  [(cognitive AO)] TJ ET
BT 405.816 671.239 Td /F1 9.8 Tf  [(mean � SD)] TJ ET
0.753 0.753 0.753 rg
463.589 665.587 50.273 15.881 re f
0.267 0.267 0.267 rg
463.214 681.094 51.023 0.750 re f
463.214 665.212 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 671.239 Td /F1 9.8 Tf  [(R�*)] TJ ET
0.753 0.753 0.753 rg
513.862 665.587 66.638 15.881 re f
0.267 0.267 0.267 rg
513.487 681.094 67.388 0.750 re f
513.487 665.212 0.750 16.631 re f
580.125 665.212 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 671.239 Td /F1 9.8 Tf  [(P value)] TJ ET
0.600 0.600 0.600 rg
27.000 649.706 131.804 15.881 re f
0.267 0.267 0.267 rg
26.625 665.213 132.554 0.750 re f
26.625 649.331 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 655.358 Td /F1 9.8 Tf  [(HD CAG 40-89 \( )] TJ ET
BT 106.102 655.358 Td /F5 9.8 Tf  [(n)] TJ ET
BT 111.523 655.358 Td /F1 9.8 Tf  [( =112\))] TJ ET
0.600 0.600 0.600 rg
158.804 649.706 85.436 15.881 re f
0.267 0.267 0.267 rg
158.429 665.213 86.186 0.750 re f
158.429 649.331 0.750 16.631 re f
0.600 0.600 0.600 rg
244.240 649.706 96.563 15.881 re f
0.267 0.267 0.267 rg
243.865 665.213 97.313 0.750 re f
243.865 649.331 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 655.358 Td /F1 9.8 Tf  [(46.34�7.8)] TJ ET
0.600 0.600 0.600 rg
340.803 649.706 122.786 15.881 re f
0.267 0.267 0.267 rg
340.428 665.213 123.536 0.750 re f
340.428 649.331 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 655.358 Td /F1 9.8 Tf  [(38.60�13.1)] TJ ET
0.600 0.600 0.600 rg
463.589 649.706 50.273 15.881 re f
0.267 0.267 0.267 rg
463.214 665.213 51.023 0.750 re f
463.214 649.331 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 655.358 Td /F1 9.8 Tf  [(0.765)] TJ ET
0.600 0.600 0.600 rg
513.862 649.706 66.638 15.881 re f
0.267 0.267 0.267 rg
513.487 665.213 67.388 0.750 re f
513.487 649.331 0.750 16.631 re f
580.125 649.331 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 655.358 Td /F1 9.8 Tf  [(<0.0005)] TJ ET
0.267 0.267 0.267 rg
26.625 649.331 132.554 0.750 re f
26.625 625.819 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 31.875 639.476 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 639.476 Td /F5 9.8 Tf  [(GRIN2B)] TJ ET
BT 76.579 639.476 Td /F1 9.8 Tf  [( C2664T )] TJ ET
BT 31.875 631.845 Td /F1 9.8 Tf  [(\(rs1806201\))] TJ ET
0.267 0.267 0.267 rg
158.429 649.331 86.186 0.750 re f
158.429 625.819 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 163.679 639.476 Td /F1 9.8 Tf  [(CC \(n=54\))] TJ ET
0.267 0.267 0.267 rg
243.865 649.331 97.313 0.750 re f
243.865 625.819 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 249.115 639.476 Td /F1 9.8 Tf  [(46.76�8.5)] TJ ET
0.267 0.267 0.267 rg
340.428 649.331 123.536 0.750 re f
340.428 625.819 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 345.678 639.476 Td /F1 9.8 Tf  [(37.89�14.2)] TJ ET
0.267 0.267 0.267 rg
463.214 649.331 51.023 0.750 re f
463.214 625.819 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 468.464 639.476 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 649.331 67.388 0.750 re f
513.487 625.819 0.750 24.262 re f
580.125 625.819 0.750 24.262 re f
0.271 0.267 0.267 rg
BT 518.737 639.476 Td /F1 9.8 Tf  [(0.621)] TJ ET
0.267 0.267 0.267 rg
26.625 625.819 132.554 0.750 re f
26.625 609.938 0.750 16.631 re f
158.429 625.819 86.186 0.750 re f
158.429 609.938 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 615.964 Td /F1 9.8 Tf  [(CT \(n=55\))] TJ ET
0.267 0.267 0.267 rg
243.865 625.819 97.313 0.750 re f
243.865 609.938 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 615.964 Td /F1 9.8 Tf  [(45.74�7.1)] TJ ET
0.267 0.267 0.267 rg
340.428 625.819 123.536 0.750 re f
340.428 609.938 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 615.964 Td /F1 9.8 Tf  [(39.73�11.9)] TJ ET
0.267 0.267 0.267 rg
463.214 625.819 51.023 0.750 re f
463.214 609.938 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 615.964 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 625.819 67.388 0.750 re f
513.487 609.938 0.750 16.631 re f
580.125 609.938 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 615.964 Td /F1 9.8 Tf  [(0.530)] TJ ET
0.267 0.267 0.267 rg
26.625 609.938 132.554 0.750 re f
26.625 594.056 0.750 16.631 re f
158.429 609.938 86.186 0.750 re f
158.429 594.056 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 600.083 Td /F1 9.8 Tf  [(TT \(n=3\))] TJ ET
0.267 0.267 0.267 rg
243.865 609.938 97.313 0.750 re f
243.865 594.056 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 600.083 Td /F1 9.8 Tf  [(50.00�6.2)] TJ ET
0.267 0.267 0.267 rg
340.428 609.938 123.536 0.750 re f
340.428 594.056 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 600.083 Td /F1 9.8 Tf  [(30.67�14.0)] TJ ET
0.267 0.267 0.267 rg
463.214 609.938 51.023 0.750 re f
463.214 594.056 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 600.083 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 609.938 67.388 0.750 re f
513.487 594.056 0.750 16.631 re f
580.125 594.056 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 600.083 Td /F1 9.8 Tf  [(0.682)] TJ ET
0.267 0.267 0.267 rg
26.625 594.056 132.554 0.750 re f
26.625 578.175 0.750 16.631 re f
158.429 594.056 86.186 0.750 re f
158.429 578.175 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 584.201 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 594.056 97.313 0.750 re f
243.865 578.175 0.750 16.631 re f
340.428 594.056 123.536 0.750 re f
340.428 578.175 0.750 16.631 re f
463.214 594.056 51.023 0.750 re f
463.214 578.175 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 584.201 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 594.056 67.388 0.750 re f
513.487 578.175 0.750 16.631 re f
580.125 578.175 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 584.201 Td /F1 9.8 Tf  [(0.742)] TJ ET
0.267 0.267 0.267 rg
26.625 578.175 132.554 0.750 re f
26.625 562.294 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 568.320 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 568.320 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 76.579 568.320 Td /F1 9.8 Tf  [( rs1969060)] TJ ET
0.267 0.267 0.267 rg
158.429 578.175 86.186 0.750 re f
158.429 562.294 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 568.320 Td /F1 9.8 Tf  [(TT \(n=74\))] TJ ET
0.267 0.267 0.267 rg
243.865 578.175 97.313 0.750 re f
243.865 562.294 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 568.320 Td /F1 9.8 Tf  [(46.24�7.8)] TJ ET
0.267 0.267 0.267 rg
340.428 578.175 123.536 0.750 re f
340.428 562.294 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 568.320 Td /F1 9.8 Tf  [(38.95�14.1)] TJ ET
0.267 0.267 0.267 rg
463.214 578.175 51.023 0.750 re f
463.214 562.294 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 568.320 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 578.175 67.388 0.750 re f
513.487 562.294 0.750 16.631 re f
580.125 562.294 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 568.320 Td /F1 9.8 Tf  [(0.682)] TJ ET
0.267 0.267 0.267 rg
26.625 562.294 132.554 0.750 re f
26.625 546.413 0.750 16.631 re f
158.429 562.294 86.186 0.750 re f
158.429 546.413 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 552.439 Td /F1 9.8 Tf  [(TC \(n=31\))] TJ ET
0.267 0.267 0.267 rg
243.865 562.294 97.313 0.750 re f
243.865 546.413 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 552.439 Td /F1 9.8 Tf  [(46.74�8.5)] TJ ET
0.267 0.267 0.267 rg
340.428 562.294 123.536 0.750 re f
340.428 546.413 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 552.439 Td /F1 9.8 Tf  [(37.68�11.4)] TJ ET
0.267 0.267 0.267 rg
463.214 562.294 51.023 0.750 re f
463.214 546.413 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 552.439 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 562.294 67.388 0.750 re f
513.487 546.413 0.750 16.631 re f
580.125 546.413 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 552.439 Td /F1 9.8 Tf  [(0.799)] TJ ET
0.267 0.267 0.267 rg
26.625 546.413 132.554 0.750 re f
26.625 530.531 0.750 16.631 re f
158.429 546.413 86.186 0.750 re f
158.429 530.531 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 536.558 Td /F1 9.8 Tf  [(CC \(n=7\))] TJ ET
0.267 0.267 0.267 rg
243.865 546.413 97.313 0.750 re f
243.865 530.531 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 536.558 Td /F1 9.8 Tf  [(45.71�3.8)] TJ ET
0.267 0.267 0.267 rg
340.428 546.413 123.536 0.750 re f
340.428 530.531 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 536.558 Td /F1 9.8 Tf  [(39.00�10.4)] TJ ET
0.267 0.267 0.267 rg
463.214 546.413 51.023 0.750 re f
463.214 530.531 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 536.558 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 546.413 67.388 0.750 re f
513.487 530.531 0.750 16.631 re f
580.125 530.531 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 536.558 Td /F1 9.8 Tf  [(0.741)] TJ ET
0.267 0.267 0.267 rg
26.625 530.531 132.554 0.750 re f
26.625 514.650 0.750 16.631 re f
158.429 530.531 86.186 0.750 re f
158.429 514.650 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 520.676 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 530.531 97.313 0.750 re f
243.865 514.650 0.750 16.631 re f
340.428 530.531 123.536 0.750 re f
340.428 514.650 0.750 16.631 re f
463.214 530.531 51.023 0.750 re f
463.214 514.650 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 520.676 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 530.531 67.388 0.750 re f
513.487 514.650 0.750 16.631 re f
580.125 514.650 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 520.676 Td /F1 9.8 Tf  [(0.650)] TJ ET
0.267 0.267 0.267 rg
26.625 514.650 132.554 0.750 re f
26.625 498.769 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 31.875 504.795 Td /F1 9.8 Tf  [(+ )] TJ ET
BT 40.279 504.795 Td /F5 9.8 Tf  [(GRIN2A)] TJ ET
BT 76.579 504.795 Td /F1 9.8 Tf  [( rs2650427)] TJ ET
0.267 0.267 0.267 rg
158.429 514.650 86.186 0.750 re f
158.429 498.769 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 504.795 Td /F1 9.8 Tf  [(CC \(n=40\))] TJ ET
0.267 0.267 0.267 rg
243.865 514.650 97.313 0.750 re f
243.865 498.769 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 504.795 Td /F1 9.8 Tf  [(45.55�4.9)] TJ ET
0.267 0.267 0.267 rg
340.428 514.650 123.536 0.750 re f
340.428 498.769 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 504.795 Td /F1 9.8 Tf  [(37.80�12.4)] TJ ET
0.267 0.267 0.267 rg
463.214 514.650 51.023 0.750 re f
463.214 498.769 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 504.795 Td /F4 9.8 Tf  [(0.770)] TJ ET
0.267 0.267 0.267 rg
513.487 514.650 67.388 0.750 re f
513.487 498.769 0.750 16.631 re f
580.125 498.769 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 504.795 Td /F4 9.8 Tf  [(0.054)] TJ ET
0.267 0.267 0.267 rg
26.625 498.769 132.554 0.750 re f
26.625 482.888 0.750 16.631 re f
158.429 498.769 86.186 0.750 re f
158.429 482.888 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 488.914 Td /F1 9.8 Tf  [(CT \(n=55\))] TJ ET
0.267 0.267 0.267 rg
243.865 498.769 97.313 0.750 re f
243.865 482.888 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 488.914 Td /F1 9.8 Tf  [(47.67�10.0)] TJ ET
0.267 0.267 0.267 rg
340.428 498.769 123.536 0.750 re f
340.428 482.888 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 488.914 Td /F1 9.8 Tf  [(36.87�13.2)] TJ ET
0.267 0.267 0.267 rg
463.214 498.769 51.023 0.750 re f
463.214 482.888 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 488.914 Td /F1 9.8 Tf  [(0.763)] TJ ET
0.267 0.267 0.267 rg
513.487 498.769 67.388 0.750 re f
513.487 482.888 0.750 16.631 re f
580.125 482.888 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 488.914 Td /F1 9.8 Tf  [(0.742)] TJ ET
0.267 0.267 0.267 rg
26.625 482.888 132.554 0.750 re f
26.625 467.006 0.750 16.631 re f
158.429 482.888 86.186 0.750 re f
158.429 467.006 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 473.033 Td /F1 9.8 Tf  [(TT \(n=17\))] TJ ET
0.267 0.267 0.267 rg
243.865 482.888 97.313 0.750 re f
243.865 467.006 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 249.115 473.033 Td /F1 9.8 Tf  [(43.9�3.2)] TJ ET
0.267 0.267 0.267 rg
340.428 482.888 123.536 0.750 re f
340.428 467.006 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 345.678 473.033 Td /F1 9.8 Tf  [(46.06�12.3)] TJ ET
0.267 0.267 0.267 rg
463.214 482.888 51.023 0.750 re f
463.214 467.006 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 473.033 Td /F4 9.8 Tf  [(0.772)] TJ ET
0.267 0.267 0.267 rg
513.487 482.888 67.388 0.750 re f
513.487 467.006 0.750 16.631 re f
580.125 467.006 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 473.033 Td /F4 9.8 Tf  [(0.033)] TJ ET
0.267 0.267 0.267 rg
26.625 467.006 132.554 0.750 re f
26.625 451.125 132.554 0.750 re f
26.625 451.125 0.750 16.631 re f
158.429 467.006 86.186 0.750 re f
158.429 451.125 86.186 0.750 re f
158.429 451.125 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 163.679 457.151 Td /F1 9.8 Tf  [(additive)] TJ ET
0.267 0.267 0.267 rg
243.865 467.006 97.313 0.750 re f
243.865 451.125 97.313 0.750 re f
243.865 451.125 0.750 16.631 re f
340.428 467.006 123.536 0.750 re f
340.428 451.125 123.536 0.750 re f
340.428 451.125 0.750 16.631 re f
463.214 467.006 51.023 0.750 re f
463.214 451.125 51.023 0.750 re f
463.214 451.125 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 468.464 457.151 Td /F4 9.8 Tf  [(0.775)] TJ ET
0.267 0.267 0.267 rg
513.487 467.006 67.388 0.750 re f
513.487 451.125 67.388 0.750 re f
513.487 451.125 0.750 16.631 re f
580.125 451.125 0.750 16.631 re f
0.271 0.267 0.267 rg
BT 518.737 457.151 Td /F4 9.8 Tf  [(0.014)] TJ ET
BT 26.250 403.726 Td /F4 9.8 Tf  [(Table )] TJ ET
BT 54.427 403.726 Td /F4 9.8 Tf  [(1)] TJ ET
BT 59.849 403.726 Td /F1 9.8 Tf  [( The variability in AO attributable to the CAG repeat length was assessed by linear regression using the logarithmically )] TJ ET
BT 26.250 391.821 Td /F1 9.8 Tf  [(transformed AO as the dependent variable and )] TJ ET
BT 231.653 391.821 Td /F5 9.8 Tf  [(GRIN)] TJ ET
BT 256.028 391.821 Td /F1 9.8 Tf  [( genotypes as independent variables. *R )] TJ ET
BT 433.790 395.710 Td /F1 8.7 Tf  [(2)] TJ ET
BT 438.609 391.821 Td /F1 9.8 Tf  [( illustrates the relative )] TJ ET
BT 26.250 379.917 Td /F1 9.8 Tf  [(improvement of the regression model, when the genotypes are considered in addition to the CAG repeats.)] TJ ET
BT 26.250 360.512 Td /F1 9.8 Tf  [(In order to control the effect of sex-specific associations, we further analysed each combination of genotype with sex, but there )] TJ ET
BT 26.250 348.607 Td /F1 9.8 Tf  [(was no trend towards significance. Moreover, on average, psychiatric and cognitive symptoms significantly predate clinical )] TJ ET
BT 26.250 336.702 Td /F1 9.8 Tf  [(motor onset by 3.5 and 4.8 years \(p< 0.001\), thus confirming that affective and cognitive symptoms could be early )] TJ ET
BT 26.250 324.798 Td /F1 9.8 Tf  [(manifestations of neuronal dysfunction.)] TJ ET
BT 26.250 288.195 Td /F4 12.0 Tf  [(Discussion)] TJ ET
BT 26.250 268.241 Td /F1 9.8 Tf  [(Of the three polymorphisms tested, GRIN2A rs2650427 showed the most consistent evidence of replication in the EHDN )] TJ ET
BT 26.250 256.336 Td /F1 9.8 Tf  [(Registry study sample. This is in accordance with another replication study in the large set of kindreds from Venezuela, where )] TJ ET
BT 26.250 244.431 Td /F1 9.8 Tf  [(GRIN2A variation also explained a small but considerable amount of additional variance in residual AO. )] TJ ET
0.267 0.267 0.267 rg
BT 474.399 244.431 Td /F1 9.8 Tf  [([5])] TJ ET
0.271 0.267 0.267 rg
BT 26.250 225.027 Td /F1 9.8 Tf  [(Yet, the interpretation of the association of cognitve AO with the GRIN2A rs2650427 polymorphism should be considered with )] TJ ET
BT 26.250 213.122 Td /F1 9.8 Tf  [(caution since the sample size of this subgroub \(n=112\) is too small to provide the statistical power required.)] TJ ET
BT 26.250 193.717 Td /F1 9.8 Tf  [(Unfortunately, none of the SNPs associated has been validated functionally and it is most likely that the polymorphisms )] TJ ET
BT 26.250 181.812 Td /F1 9.8 Tf  [(analysed are not the functional variations, but represent markers in linkage disequilibrium with variations that modify the AO. )] TJ ET
BT 26.250 169.908 Td /F1 9.8 Tf  [(Although, synonymous SNPs like GRIN2B rs1806201 might be pathogenetically relevant via influencing mRNA splicing, protein )] TJ ET
BT 26.250 158.003 Td /F1 9.8 Tf  [(stability and structure.)] TJ ET
BT 26.250 138.598 Td /F1 9.8 Tf  [(The failure to replicate the sex-specific effect of rs1806201 suggests that the original observation may have been false positive, )] TJ ET
BT 26.250 126.693 Td /F1 9.8 Tf  [(emphasizing the need for stringent statistical thresholds. On the other hand, since linkage disequilibrium is not uniform across )] TJ ET
BT 26.250 114.789 Td /F1 9.8 Tf  [(populations, the mixed ancestry in the EHDN REGISTRY study sample could account for heterogeneous results. Inconsistent )] TJ ET
BT 26.250 102.884 Td /F1 9.8 Tf  [(results may also occur because of difficulties in exact AO definitions. The data stresses the need for precise phenotyping in )] TJ ET
BT 26.250 90.979 Td /F1 9.8 Tf  [(order to reduce heterogeneity, and to facilitate the discovery of clinically relevant biological pathways.)] TJ ET
Q
q
0.000 0.000 0.000 rg
BT 291.710 19.825 Td /F1 11.0 Tf  [(3)] TJ ET
BT 25.000 19.825 Td /F1 11.0 Tf  [(PLOS Currents Huntington Disease)] TJ ET

Q
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0.271 0.267 0.267 rg
q
15.000 39.098 577.500 737.902 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(Although the associations replicated explain only a small fraction of the variance of AO, the observed correlations with HD )] TJ ET
BT 26.250 755.571 Td /F1 9.8 Tf  [(phenotypes demonstrate that GRIN2A and GRIN2B remain promising candidate genes, worth to be studied further in more )] TJ ET
BT 26.250 743.667 Td /F1 9.8 Tf  [(detail.)] TJ ET
BT 26.250 707.064 Td /F4 12.0 Tf  [(Acknowledgments)] TJ ET
BT 26.250 687.110 Td /F1 9.8 Tf  [(The authors thank all EHDN Registry Study Group investigators for collecting the data and all participating patients for their time )] TJ ET
BT 26.250 675.205 Td /F1 9.8 Tf  [(and efforts.)] TJ ET
BT 26.250 655.800 Td /F1 9.8 Tf  [(Correspondence to Dr Larissa Arning, Ruhr-University, Department of Human Genetics, Universit�tsstr. 150, MA5/39, 44801 )] TJ ET
BT 26.250 643.896 Td /F1 9.8 Tf  [(Bochum, Germany, larissa.arning@rub.de)] TJ ET
BT 26.250 607.293 Td /F4 12.0 Tf  [(Competing interests)] TJ ET
BT 26.250 587.339 Td /F1 9.8 Tf  [(The authors have declared that no competing interests exist.)] TJ ET
BT 26.250 550.736 Td /F4 12.0 Tf  [(Funding information)] TJ ET
BT 26.250 530.782 Td /F1 9.8 Tf  [(The European Huntington�s Disease Network is funded by CHDI Foundation, Inc. CS was supported by FoRUM grant K040-09.)] TJ ET
BT 26.250 494.180 Td /F4 12.0 Tf  [(Ethics approval)] TJ ET
BT 26.250 474.225 Td /F1 9.8 Tf  [(This study was conducted with the approval of the local ethics committee of the different clinical centres.)] TJ ET
BT 26.250 437.623 Td /F4 12.0 Tf  [(Expansion of Collaborator List)] TJ ET
BT 26.250 417.669 Td /F4 9.8 Tf  [(Investigators of the European Huntington�s Disease Network)] TJ ET
BT 26.250 398.264 Td /F1 9.8 Tf  [(K Barth, Language coordinator)] TJ ET
BT 26.250 378.859 Td /F1 9.8 Tf  [(M Bascu�ana Garde, Language coordinator)] TJ ET
BT 26.250 359.454 Td /F1 9.8 Tf  [(R Bos, Language coordinator)] TJ ET
BT 26.250 340.050 Td /F1 9.8 Tf  [(D Ecker, Language coordinator)] TJ ET
BT 26.250 320.645 Td /F1 9.8 Tf  [(OJ Handley, Language coordinator)] TJ ET
BT 26.250 301.240 Td /F1 9.8 Tf  [(N Heinonen, Language coordinator)] TJ ET
BT 26.250 281.835 Td /F1 9.8 Tf  [(C Held, Language coordinator)] TJ ET
BT 26.250 262.431 Td /F1 9.8 Tf  [(M Laur�, Language coordinator)] TJ ET
BT 26.250 243.026 Td /F1 9.8 Tf  [(A Mart�nez Descals, Language coordinator)] TJ ET
BT 26.250 223.621 Td /F1 9.8 Tf  [(T Mestre, Language coordinator)] TJ ET
BT 26.250 204.216 Td /F1 9.8 Tf  [(D Monza, Language coordinator)] TJ ET
BT 26.250 184.812 Td /F1 9.8 Tf  [(J Naji, Language coordinator)] TJ ET
BT 26.250 165.407 Td /F1 9.8 Tf  [(M Orth, Language coordinator)] TJ ET
BT 26.250 146.002 Td /F1 9.8 Tf  [(H Padieu, Language coordinator)] TJ ET
BT 26.250 126.597 Td /F1 9.8 Tf  [(S Pro Koivisto, Language coordinator)] TJ ET
BT 26.250 107.193 Td /F1 9.8 Tf  [(A Rialland, Language coordinator)] TJ ET
BT 26.250 87.788 Td /F1 9.8 Tf  [(P Sasinkov�, Language coordinator)] TJ ET
BT 26.250 68.383 Td /F1 9.8 Tf  [(P Trigo Cubillo, Language coordinator)] TJ ET
BT 26.250 48.978 Td /F1 9.8 Tf  [(M van Walsem, Language coordinator)] TJ ET
Q
q
15.000 39.098 577.500 737.902 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(Although the associations replicated explain only a small fraction of the variance of AO, the observed correlations with HD )] TJ ET
BT 26.250 755.571 Td /F1 9.8 Tf  [(phenotypes demonstrate that GRIN2A and GRIN2B remain promising candidate genes, worth to be studied further in more )] TJ ET
BT 26.250 743.667 Td /F1 9.8 Tf  [(detail.)] TJ ET
BT 26.250 707.064 Td /F4 12.0 Tf  [(Acknowledgments)] TJ ET
BT 26.250 687.110 Td /F1 9.8 Tf  [(The authors thank all EHDN Registry Study Group investigators for collecting the data and all participating patients for their time )] TJ ET
BT 26.250 675.205 Td /F1 9.8 Tf  [(and efforts.)] TJ ET
BT 26.250 655.800 Td /F1 9.8 Tf  [(Correspondence to Dr Larissa Arning, Ruhr-University, Department of Human Genetics, Universit�tsstr. 150, MA5/39, 44801 )] TJ ET
BT 26.250 643.896 Td /F1 9.8 Tf  [(Bochum, Germany, larissa.arning@rub.de)] TJ ET
BT 26.250 607.293 Td /F4 12.0 Tf  [(Competing interests)] TJ ET
BT 26.250 587.339 Td /F1 9.8 Tf  [(The authors have declared that no competing interests exist.)] TJ ET
BT 26.250 550.736 Td /F4 12.0 Tf  [(Funding information)] TJ ET
BT 26.250 530.782 Td /F1 9.8 Tf  [(The European Huntington�s Disease Network is funded by CHDI Foundation, Inc. CS was supported by FoRUM grant K040-09.)] TJ ET
BT 26.250 494.180 Td /F4 12.0 Tf  [(Ethics approval)] TJ ET
BT 26.250 474.225 Td /F1 9.8 Tf  [(This study was conducted with the approval of the local ethics committee of the different clinical centres.)] TJ ET
BT 26.250 437.623 Td /F4 12.0 Tf  [(Expansion of Collaborator List)] TJ ET
BT 26.250 417.669 Td /F4 9.8 Tf  [(Investigators of the European Huntington�s Disease Network)] TJ ET
BT 26.250 398.264 Td /F1 9.8 Tf  [(K Barth, Language coordinator)] TJ ET
BT 26.250 378.859 Td /F1 9.8 Tf  [(M Bascu�ana Garde, Language coordinator)] TJ ET
BT 26.250 359.454 Td /F1 9.8 Tf  [(R Bos, Language coordinator)] TJ ET
BT 26.250 340.050 Td /F1 9.8 Tf  [(D Ecker, Language coordinator)] TJ ET
BT 26.250 320.645 Td /F1 9.8 Tf  [(OJ Handley, Language coordinator)] TJ ET
BT 26.250 301.240 Td /F1 9.8 Tf  [(N Heinonen, Language coordinator)] TJ ET
BT 26.250 281.835 Td /F1 9.8 Tf  [(C Held, Language coordinator)] TJ ET
BT 26.250 262.431 Td /F1 9.8 Tf  [(M Laur�, Language coordinator)] TJ ET
BT 26.250 243.026 Td /F1 9.8 Tf  [(A Mart�nez Descals, Language coordinator)] TJ ET
BT 26.250 223.621 Td /F1 9.8 Tf  [(T Mestre, Language coordinator)] TJ ET
BT 26.250 204.216 Td /F1 9.8 Tf  [(D Monza, Language coordinator)] TJ ET
BT 26.250 184.812 Td /F1 9.8 Tf  [(J Naji, Language coordinator)] TJ ET
BT 26.250 165.407 Td /F1 9.8 Tf  [(M Orth, Language coordinator)] TJ ET
BT 26.250 146.002 Td /F1 9.8 Tf  [(H Padieu, Language coordinator)] TJ ET
BT 26.250 126.597 Td /F1 9.8 Tf  [(S Pro Koivisto, Language coordinator)] TJ ET
BT 26.250 107.193 Td /F1 9.8 Tf  [(A Rialland, Language coordinator)] TJ ET
BT 26.250 87.788 Td /F1 9.8 Tf  [(P Sasinkov�, Language coordinator)] TJ ET
BT 26.250 68.383 Td /F1 9.8 Tf  [(P Trigo Cubillo, Language coordinator)] TJ ET
BT 26.250 48.978 Td /F1 9.8 Tf  [(M van Walsem, Language coordinator)] TJ ET
Q
q
15.000 39.098 577.500 737.902 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(Although the associations replicated explain only a small fraction of the variance of AO, the observed correlations with HD )] TJ ET
BT 26.250 755.571 Td /F1 9.8 Tf  [(phenotypes demonstrate that GRIN2A and GRIN2B remain promising candidate genes, worth to be studied further in more )] TJ ET
BT 26.250 743.667 Td /F1 9.8 Tf  [(detail.)] TJ ET
BT 26.250 707.064 Td /F4 12.0 Tf  [(Acknowledgments)] TJ ET
BT 26.250 687.110 Td /F1 9.8 Tf  [(The authors thank all EHDN Registry Study Group investigators for collecting the data and all participating patients for their time )] TJ ET
BT 26.250 675.205 Td /F1 9.8 Tf  [(and efforts.)] TJ ET
BT 26.250 655.800 Td /F1 9.8 Tf  [(Correspondence to Dr Larissa Arning, Ruhr-University, Department of Human Genetics, Universit�tsstr. 150, MA5/39, 44801 )] TJ ET
BT 26.250 643.896 Td /F1 9.8 Tf  [(Bochum, Germany, larissa.arning@rub.de)] TJ ET
BT 26.250 607.293 Td /F4 12.0 Tf  [(Competing interests)] TJ ET
BT 26.250 587.339 Td /F1 9.8 Tf  [(The authors have declared that no competing interests exist.)] TJ ET
BT 26.250 550.736 Td /F4 12.0 Tf  [(Funding information)] TJ ET
BT 26.250 530.782 Td /F1 9.8 Tf  [(The European Huntington�s Disease Network is funded by CHDI Foundation, Inc. CS was supported by FoRUM grant K040-09.)] TJ ET
BT 26.250 494.180 Td /F4 12.0 Tf  [(Ethics approval)] TJ ET
BT 26.250 474.225 Td /F1 9.8 Tf  [(This study was conducted with the approval of the local ethics committee of the different clinical centres.)] TJ ET
BT 26.250 437.623 Td /F4 12.0 Tf  [(Expansion of Collaborator List)] TJ ET
BT 26.250 417.669 Td /F4 9.8 Tf  [(Investigators of the European Huntington�s Disease Network)] TJ ET
BT 26.250 398.264 Td /F1 9.8 Tf  [(K Barth, Language coordinator)] TJ ET
BT 26.250 378.859 Td /F1 9.8 Tf  [(M Bascu�ana Garde, Language coordinator)] TJ ET
BT 26.250 359.454 Td /F1 9.8 Tf  [(R Bos, Language coordinator)] TJ ET
BT 26.250 340.050 Td /F1 9.8 Tf  [(D Ecker, Language coordinator)] TJ ET
BT 26.250 320.645 Td /F1 9.8 Tf  [(OJ Handley, Language coordinator)] TJ ET
BT 26.250 301.240 Td /F1 9.8 Tf  [(N Heinonen, Language coordinator)] TJ ET
BT 26.250 281.835 Td /F1 9.8 Tf  [(C Held, Language coordinator)] TJ ET
BT 26.250 262.431 Td /F1 9.8 Tf  [(M Laur�, Language coordinator)] TJ ET
BT 26.250 243.026 Td /F1 9.8 Tf  [(A Mart�nez Descals, Language coordinator)] TJ ET
BT 26.250 223.621 Td /F1 9.8 Tf  [(T Mestre, Language coordinator)] TJ ET
BT 26.250 204.216 Td /F1 9.8 Tf  [(D Monza, Language coordinator)] TJ ET
BT 26.250 184.812 Td /F1 9.8 Tf  [(J Naji, Language coordinator)] TJ ET
BT 26.250 165.407 Td /F1 9.8 Tf  [(M Orth, Language coordinator)] TJ ET
BT 26.250 146.002 Td /F1 9.8 Tf  [(H Padieu, Language coordinator)] TJ ET
BT 26.250 126.597 Td /F1 9.8 Tf  [(S Pro Koivisto, Language coordinator)] TJ ET
BT 26.250 107.193 Td /F1 9.8 Tf  [(A Rialland, Language coordinator)] TJ ET
BT 26.250 87.788 Td /F1 9.8 Tf  [(P Sasinkov�, Language coordinator)] TJ ET
BT 26.250 68.383 Td /F1 9.8 Tf  [(P Trigo Cubillo, Language coordinator)] TJ ET
BT 26.250 48.978 Td /F1 9.8 Tf  [(M van Walsem, Language coordinator)] TJ ET
Q
q
0.000 0.000 0.000 rg
BT 291.710 19.825 Td /F1 11.0 Tf  [(4)] TJ ET
BT 25.000 19.825 Td /F1 11.0 Tf  [(PLOS Currents Huntington Disease)] TJ ET

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q
15.000 39.619 577.500 737.381 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(M-N Witjes-An�, Language coordinator)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(D Zielonka, Language coordinator)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Raphael M. Bonelli, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 709.262 Td /F1 9.8 Tf  [(Brigitte Herranhof, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 689.857 Td /F1 9.8 Tf  [(Anna H�dl, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 670.452 Td /F1 9.8 Tf  [(Hans-Peter Kapfhammer, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 651.048 Td /F1 9.8 Tf  [(Michael Koppitz, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 631.643 Td /F1 9.8 Tf  [(Markus Magnet, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 612.238 Td /F1 9.8 Tf  [(Daniela Otti, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 592.833 Td /F1 9.8 Tf  [(Annamaria Painold, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 573.429 Td /F1 9.8 Tf  [(Karin Reisinge, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 554.024 Td /F1 9.8 Tf  [(Florian Brugger,Universit�tsklinik f�r Neurologie, Innsbruck, Austria)] TJ ET
BT 26.250 534.619 Td /F1 9.8 Tf  [(Caroline Hepperger, Universit�tsklinik f�r Neurologie, Innsbruck, Austria)] TJ ET
BT 26.250 515.214 Td /F1 9.8 Tf  [(Anna Hotter, Universit�tsklinik f�r Neurologie, Innsbruck, Austria)] TJ ET
BT 26.250 495.810 Td /F1 9.8 Tf  [(Philipp Mahlknecht, Universit�tsklinik f�r Neurologie, Innsbruck, Austria)] TJ ET
BT 26.250 476.405 Td /F1 9.8 Tf  [(Michael Nocker, Universit�tsklinik f�r Neurologie, Innsbruck, Austria)] TJ ET
BT 26.250 457.000 Td /F1 9.8 Tf  [(Klaus Seppi, Universit�tsklinik f�r Neurologie, Innsbruck, Austria)] TJ ET
BT 26.250 437.595 Td /F1 9.8 Tf  [(Gregor Wenning, Universit�tsklinik f�r Neurologie, Innsbruck, Austria)] TJ ET
BT 26.250 418.191 Td /F1 9.8 Tf  [(Pascale Riba�, Institut de Pathologie et de G�n�tiqu, C)] TJ ET
BT 26.250 398.786 Td /F1 9.8 Tf  [(Christine Verellen-Dumoulin ,Institut de Pathologie et de G�n�tiqu, Charleroi, Belgiu)] TJ ET
BT 26.250 379.381 Td /F1 9.8 Tf  [(Ji?� Klemp�?, Centrum extrapyramidov�ch onemocn?n�, Prague, Czech Republic)] TJ ET
BT 26.250 359.976 Td /F1 9.8 Tf  [(Martin Kucharik, Centrum extrapyramidov�ch onemocn?n�, Prague, Czech Republic)] TJ ET
BT 26.250 340.572 Td /F1 9.8 Tf  [(Jan Roth, Centrum extrapyramidov�ch onemocn?n�, Prague, Czech Republic)] TJ ET
BT 26.250 321.167 Td /F1 9.8 Tf  [(Lis Hasholt, Hukommelsesklinikken, Rigshospitalet, Copehnhagen, Denmark)] TJ ET
BT 26.250 301.762 Td /F1 9.8 Tf  [(Lena E. Hjermind, Hukommelsesklinikken, Rigshospitalet, Copehnhagen, Denmark)] TJ ET
BT 26.250 282.357 Td /F1 9.8 Tf  [(Oda Jakobsen, Hukommelsesklinikken, Rigshospitalet, Copehnhagen, Denmark)] TJ ET
BT 26.250 262.953 Td /F1 9.8 Tf  [(J�rgen E Nielsen, Hukommelsesklinikken, Rigshospitalet, Copehnhagen, Denmark)] TJ ET
BT 26.250 243.548 Td /F1 9.8 Tf  [(Anne N�rrem�lle, Hukommelsesklinikken, Rigshospitalet, Copehnhagen, Denmark)] TJ ET
BT 26.250 224.143 Td /F1 9.8 Tf  [(Sven Asger S�rensen, Hukommelsesklinikken, Rigshospitalet, Copehnhagen, Denmark)] TJ ET
BT 26.250 204.738 Td /F1 9.8 Tf  [(Jette Stokholm, Hukommelsesklinikken, Rigshospitalet, Copehnhagen, Denmark)] TJ ET
BT 26.250 185.334 Td /F1 9.8 Tf  [(Heli Hiivola, Rehabilitation Centre Suvituuli, Turku-Suvituuli, Finland)] TJ ET
BT 26.250 165.929 Td /F1 9.8 Tf  [(Kirsti Martikainen, Rehabilitation Centre Suvituuli, Turku-Suvituuli, Finland)] TJ ET
BT 26.250 146.524 Td /F1 9.8 Tf  [(Katri Tuuha, Rehabilitation Centre Suvituuli, Turku-Suvituuli, Finland)] TJ ET
BT 26.250 127.119 Td /F1 9.8 Tf  [(Christoph Michael Kosinski, Universit�tsklinikum Aachen, Neurologische Klinik, Germany)] TJ ET
BT 26.250 107.715 Td /F1 9.8 Tf  [(Daniela Probst, Universit�tsklinikum Aachen, Neurologische Klinik, Germany)] TJ ET
BT 26.250 88.310 Td /F1 9.8 Tf  [(Christian Sass, Universit�tsklinikum Aachen, Neurologische Klinik, Germany)] TJ ET
BT 26.250 68.905 Td /F1 9.8 Tf  [(Johannes Schiefer, Universit�tsklinikum Aachen, Neurologische Klinik, Germany)] TJ ET
BT 26.250 49.500 Td /F1 9.8 Tf  [(Christiane Schlangen, Universit�tsklinikum Aachen, Neurologische Klinik, Germany)] TJ ET
Q
q
15.000 39.619 577.500 737.381 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(M-N Witjes-An�, Language coordinator)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(D Zielonka, Language coordinator)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Raphael M. Bonelli, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 709.262 Td /F1 9.8 Tf  [(Brigitte Herranhof, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 689.857 Td /F1 9.8 Tf  [(Anna H�dl, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 670.452 Td /F1 9.8 Tf  [(Hans-Peter Kapfhammer, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 651.048 Td /F1 9.8 Tf  [(Michael Koppitz, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 631.643 Td /F1 9.8 Tf  [(Markus Magnet, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 612.238 Td /F1 9.8 Tf  [(Daniela Otti, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 592.833 Td /F1 9.8 Tf  [(Annamaria Painold, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 573.429 Td /F1 9.8 Tf  [(Karin Reisinge, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 554.024 Td /F1 9.8 Tf  [(Florian Brugger,Universit�tsklinik f�r Neurologie, Innsbruck, Austria)] TJ ET
BT 26.250 534.619 Td /F1 9.8 Tf  [(Caroline Hepperger, Universit�tsklinik f�r Neurologie, Innsbruck, Austria)] TJ ET
BT 26.250 515.214 Td /F1 9.8 Tf  [(Anna Hotter, Universit�tsklinik f�r Neurologie, Innsbruck, Austria)] TJ ET
BT 26.250 495.810 Td /F1 9.8 Tf  [(Philipp Mahlknecht, Universit�tsklinik f�r Neurologie, Innsbruck, Austria)] TJ ET
BT 26.250 476.405 Td /F1 9.8 Tf  [(Michael Nocker, Universit�tsklinik f�r Neurologie, Innsbruck, Austria)] TJ ET
BT 26.250 457.000 Td /F1 9.8 Tf  [(Klaus Seppi, Universit�tsklinik f�r Neurologie, Innsbruck, Austria)] TJ ET
BT 26.250 437.595 Td /F1 9.8 Tf  [(Gregor Wenning, Universit�tsklinik f�r Neurologie, Innsbruck, Austria)] TJ ET
BT 26.250 418.191 Td /F1 9.8 Tf  [(Pascale Riba�, Institut de Pathologie et de G�n�tiqu, C)] TJ ET
BT 26.250 398.786 Td /F1 9.8 Tf  [(Christine Verellen-Dumoulin ,Institut de Pathologie et de G�n�tiqu, Charleroi, Belgiu)] TJ ET
BT 26.250 379.381 Td /F1 9.8 Tf  [(Ji?� Klemp�?, Centrum extrapyramidov�ch onemocn?n�, Prague, Czech Republic)] TJ ET
BT 26.250 359.976 Td /F1 9.8 Tf  [(Martin Kucharik, Centrum extrapyramidov�ch onemocn?n�, Prague, Czech Republic)] TJ ET
BT 26.250 340.572 Td /F1 9.8 Tf  [(Jan Roth, Centrum extrapyramidov�ch onemocn?n�, Prague, Czech Republic)] TJ ET
BT 26.250 321.167 Td /F1 9.8 Tf  [(Lis Hasholt, Hukommelsesklinikken, Rigshospitalet, Copehnhagen, Denmark)] TJ ET
BT 26.250 301.762 Td /F1 9.8 Tf  [(Lena E. Hjermind, Hukommelsesklinikken, Rigshospitalet, Copehnhagen, Denmark)] TJ ET
BT 26.250 282.357 Td /F1 9.8 Tf  [(Oda Jakobsen, Hukommelsesklinikken, Rigshospitalet, Copehnhagen, Denmark)] TJ ET
BT 26.250 262.953 Td /F1 9.8 Tf  [(J�rgen E Nielsen, Hukommelsesklinikken, Rigshospitalet, Copehnhagen, Denmark)] TJ ET
BT 26.250 243.548 Td /F1 9.8 Tf  [(Anne N�rrem�lle, Hukommelsesklinikken, Rigshospitalet, Copehnhagen, Denmark)] TJ ET
BT 26.250 224.143 Td /F1 9.8 Tf  [(Sven Asger S�rensen, Hukommelsesklinikken, Rigshospitalet, Copehnhagen, Denmark)] TJ ET
BT 26.250 204.738 Td /F1 9.8 Tf  [(Jette Stokholm, Hukommelsesklinikken, Rigshospitalet, Copehnhagen, Denmark)] TJ ET
BT 26.250 185.334 Td /F1 9.8 Tf  [(Heli Hiivola, Rehabilitation Centre Suvituuli, Turku-Suvituuli, Finland)] TJ ET
BT 26.250 165.929 Td /F1 9.8 Tf  [(Kirsti Martikainen, Rehabilitation Centre Suvituuli, Turku-Suvituuli, Finland)] TJ ET
BT 26.250 146.524 Td /F1 9.8 Tf  [(Katri Tuuha, Rehabilitation Centre Suvituuli, Turku-Suvituuli, Finland)] TJ ET
BT 26.250 127.119 Td /F1 9.8 Tf  [(Christoph Michael Kosinski, Universit�tsklinikum Aachen, Neurologische Klinik, Germany)] TJ ET
BT 26.250 107.715 Td /F1 9.8 Tf  [(Daniela Probst, Universit�tsklinikum Aachen, Neurologische Klinik, Germany)] TJ ET
BT 26.250 88.310 Td /F1 9.8 Tf  [(Christian Sass, Universit�tsklinikum Aachen, Neurologische Klinik, Germany)] TJ ET
BT 26.250 68.905 Td /F1 9.8 Tf  [(Johannes Schiefer, Universit�tsklinikum Aachen, Neurologische Klinik, Germany)] TJ ET
BT 26.250 49.500 Td /F1 9.8 Tf  [(Christiane Schlangen, Universit�tsklinikum Aachen, Neurologische Klinik, Germany)] TJ ET
Q
q
15.000 39.619 577.500 737.381 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(M-N Witjes-An�, Language coordinator)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(D Zielonka, Language coordinator)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Raphael M. Bonelli, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 709.262 Td /F1 9.8 Tf  [(Brigitte Herranhof, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 689.857 Td /F1 9.8 Tf  [(Anna H�dl, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 670.452 Td /F1 9.8 Tf  [(Hans-Peter Kapfhammer, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 651.048 Td /F1 9.8 Tf  [(Michael Koppitz, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 631.643 Td /F1 9.8 Tf  [(Markus Magnet, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 612.238 Td /F1 9.8 Tf  [(Daniela Otti, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 592.833 Td /F1 9.8 Tf  [(Annamaria Painold, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 573.429 Td /F1 9.8 Tf  [(Karin Reisinge, LKH Graz, Abteilung f�r Psychiatrie, Austria)] TJ ET
BT 26.250 554.024 Td /F1 9.8 Tf  [(Florian Brugger,Universit�tsklinik f�r Neurologie, Innsbruck, Austria)] TJ ET
BT 26.250 534.619 Td /F1 9.8 Tf  [(Caroline Hepperger, Universit�tsklinik f�r Neurologie, Innsbruck, Austria)] TJ ET
BT 26.250 515.214 Td /F1 9.8 Tf  [(Anna Hotter, Universit�tsklinik f�r Neurologie, Innsbruck, Austria)] TJ ET
BT 26.250 495.810 Td /F1 9.8 Tf  [(Philipp Mahlknecht, Universit�tsklinik f�r Neurologie, Innsbruck, Austria)] TJ ET
BT 26.250 476.405 Td /F1 9.8 Tf  [(Michael Nocker, Universit�tsklinik f�r Neurologie, Innsbruck, Austria)] TJ ET
BT 26.250 457.000 Td /F1 9.8 Tf  [(Klaus Seppi, Universit�tsklinik f�r Neurologie, Innsbruck, Austria)] TJ ET
BT 26.250 437.595 Td /F1 9.8 Tf  [(Gregor Wenning, Universit�tsklinik f�r Neurologie, Innsbruck, Austria)] TJ ET
BT 26.250 418.191 Td /F1 9.8 Tf  [(Pascale Riba�, Institut de Pathologie et de G�n�tiqu, C)] TJ ET
BT 26.250 398.786 Td /F1 9.8 Tf  [(Christine Verellen-Dumoulin ,Institut de Pathologie et de G�n�tiqu, Charleroi, Belgiu)] TJ ET
BT 26.250 379.381 Td /F1 9.8 Tf  [(Ji?� Klemp�?, Centrum extrapyramidov�ch onemocn?n�, Prague, Czech Republic)] TJ ET
BT 26.250 359.976 Td /F1 9.8 Tf  [(Martin Kucharik, Centrum extrapyramidov�ch onemocn?n�, Prague, Czech Republic)] TJ ET
BT 26.250 340.572 Td /F1 9.8 Tf  [(Jan Roth, Centrum extrapyramidov�ch onemocn?n�, Prague, Czech Republic)] TJ ET
BT 26.250 321.167 Td /F1 9.8 Tf  [(Lis Hasholt, Hukommelsesklinikken, Rigshospitalet, Copehnhagen, Denmark)] TJ ET
BT 26.250 301.762 Td /F1 9.8 Tf  [(Lena E. Hjermind, Hukommelsesklinikken, Rigshospitalet, Copehnhagen, Denmark)] TJ ET
BT 26.250 282.357 Td /F1 9.8 Tf  [(Oda Jakobsen, Hukommelsesklinikken, Rigshospitalet, Copehnhagen, Denmark)] TJ ET
BT 26.250 262.953 Td /F1 9.8 Tf  [(J�rgen E Nielsen, Hukommelsesklinikken, Rigshospitalet, Copehnhagen, Denmark)] TJ ET
BT 26.250 243.548 Td /F1 9.8 Tf  [(Anne N�rrem�lle, Hukommelsesklinikken, Rigshospitalet, Copehnhagen, Denmark)] TJ ET
BT 26.250 224.143 Td /F1 9.8 Tf  [(Sven Asger S�rensen, Hukommelsesklinikken, Rigshospitalet, Copehnhagen, Denmark)] TJ ET
BT 26.250 204.738 Td /F1 9.8 Tf  [(Jette Stokholm, Hukommelsesklinikken, Rigshospitalet, Copehnhagen, Denmark)] TJ ET
BT 26.250 185.334 Td /F1 9.8 Tf  [(Heli Hiivola, Rehabilitation Centre Suvituuli, Turku-Suvituuli, Finland)] TJ ET
BT 26.250 165.929 Td /F1 9.8 Tf  [(Kirsti Martikainen, Rehabilitation Centre Suvituuli, Turku-Suvituuli, Finland)] TJ ET
BT 26.250 146.524 Td /F1 9.8 Tf  [(Katri Tuuha, Rehabilitation Centre Suvituuli, Turku-Suvituuli, Finland)] TJ ET
BT 26.250 127.119 Td /F1 9.8 Tf  [(Christoph Michael Kosinski, Universit�tsklinikum Aachen, Neurologische Klinik, Germany)] TJ ET
BT 26.250 107.715 Td /F1 9.8 Tf  [(Daniela Probst, Universit�tsklinikum Aachen, Neurologische Klinik, Germany)] TJ ET
BT 26.250 88.310 Td /F1 9.8 Tf  [(Christian Sass, Universit�tsklinikum Aachen, Neurologische Klinik, Germany)] TJ ET
BT 26.250 68.905 Td /F1 9.8 Tf  [(Johannes Schiefer, Universit�tsklinikum Aachen, Neurologische Klinik, Germany)] TJ ET
BT 26.250 49.500 Td /F1 9.8 Tf  [(Christiane Schlangen, Universit�tsklinikum Aachen, Neurologische Klinik, Germany)] TJ ET
Q
q
0.000 0.000 0.000 rg
BT 291.710 19.825 Td /F1 11.0 Tf  [(5)] TJ ET
BT 25.000 19.825 Td /F1 11.0 Tf  [(PLOS Currents Huntington Disease)] TJ ET

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0.271 0.267 0.267 rg
q
15.000 33.905 577.500 743.095 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(Cornelius J. Werner, Universit�tsklinikum Aachen, Neurologische Klinik, Germany)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(Herwig Lange, Reha Zentrum in Dinslaken im Gesundheitszentrums Lang, Dinslake, Germany)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Matthias L�hle, Universit�tsklinikum Carl Gustav Carus an der Technischen Universit�t Dresden, Klinik und Poliklinik f�r )] TJ ET
BT 26.250 716.762 Td /F1 9.8 Tf  [(Neurologie, Dresden, Germany)] TJ ET
BT 26.250 697.357 Td /F1 9.8 Tf  [(Alexander Storch, Universit�tsklinikum Carl Gustav Carus an der Technischen Universit�t Dresden, Klinik und Poliklinik f�r )] TJ ET
BT 26.250 685.452 Td /F1 9.8 Tf  [(Neurologie, Dresden, Germany)] TJ ET
BT 26.250 666.048 Td /F1 9.8 Tf  [(Anett Wolz, Universit�tsklinikum Carl Gustav Carus an der Technischen Universit�t Dresden, Klinik und Poliklinik f�r )] TJ ET
BT 26.250 654.143 Td /F1 9.8 Tf  [(Neurologie, Dresden, Germany)] TJ ET
BT 26.250 634.738 Td /F1 9.8 Tf  [(Martin Wolz, Universit�tsklinikum Carl Gustav Carus an der Technischen Universit�t Dresden, Klinik und Poliklinik f�r )] TJ ET
BT 26.250 622.833 Td /F1 9.8 Tf  [(Neurologie, Dresden, Germany)] TJ ET
BT 26.250 603.429 Td /F1 9.8 Tf  [(Johann Lambeck, Universit�tsklinik Freiburg, Neurologie, Freiburg, Germany)] TJ ET
BT 26.250 584.024 Td /F1 9.8 Tf  [(Birgit Zucker, Universit�tsklinik Freiburg, Neurologie, Freiburg, Germany)] TJ ET
BT 26.250 564.619 Td /F1 9.8 Tf  [(Alexander M�nchau, Universit�tsklinikum Hamburg-Eppendorf, Klinik und Poliklinik f�r Neurologie, Hamburg, Germany)] TJ ET
BT 26.250 545.214 Td /F1 9.8 Tf  [(Lars Stubbe, Universit�tsklinikum Hamburg-Eppendorf, Klinik und Poliklinik f�r Neurologie, Hamburg, Germany)] TJ ET
BT 26.250 525.810 Td /F1 9.8 Tf  [(Simone Zittel, Universit�tsklinikum Hamburg-Eppendorf, Klinik und Poliklinik f�r Neurologie, Hamburg, Germany)] TJ ET
BT 26.250 506.405 Td /F1 9.8 Tf  [(Walburgis Heinicke, Psychatrium Heiligenhafen, Germany)] TJ ET
BT 26.250 487.000 Td /F1 9.8 Tf  [(Bernhard Longinus, Klinik f�r Psychiatrie und Psychotherapie Marburg-S�d, Germany)] TJ ET
BT 26.250 467.595 Td /F1 9.8 Tf  [(Alexander Peinemann, Huntington-Ambulanz im Neuro-Kopfzentrum � Klinikum rechts der Isar der Neurologischen Klinik und )] TJ ET
BT 26.250 455.691 Td /F1 9.8 Tf  [(Poliklinik der Technischen Universit�t M�nchen, Germany)] TJ ET
BT 26.250 436.286 Td /F1 9.8 Tf  [(Michael St�dtler, Huntington-Ambulanz im Neuro-Kopfzentrum � Klinikum rechts der Isar der Neurologischen Klinik und )] TJ ET
BT 26.250 424.381 Td /F1 9.8 Tf  [(Poliklinik der Technischen Universit�t M�nchen, Germany)] TJ ET
BT 26.250 404.976 Td /F1 9.8 Tf  [(Adolf Weindl, Huntington-Ambulanz im Neuro-Kopfzentrum � Klinikum rechts der Isar der Neurologischen Klinik und Poliklinik )] TJ ET
BT 26.250 393.072 Td /F1 9.8 Tf  [(der Technischen Universit�t M�nchen, Germany)] TJ ET
BT 26.250 373.667 Td /F1 9.8 Tf  [(Stefan Bohlen, Universit�tsklinikum M�nster, Klinik und Poliklinik f�r Neurologie, M�nster, Germany)] TJ ET
BT 26.250 354.262 Td /F1 9.8 Tf  [(Herwig Lange, Universit�tsklinikum M�nster, Klinik und Poliklinik f�r Neurologie, M�nster, Germany)] TJ ET
BT 26.250 334.857 Td /F1 9.8 Tf  [(Ralf Reilmann, Universit�tsklinikum M�nster, Klinik und Poliklinik f�r Neurologie, M�nster, Germany)] TJ ET
BT 26.250 315.453 Td /F1 9.8 Tf  [(Antonie Beister, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 296.048 Td /F1 9.8 Tf  [(Matthias Dose, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 276.643 Td /F1 9.8 Tf  [(Kathrin Hammer, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 257.238 Td /F1 9.8 Tf  [(Gabriele Leythaeuser, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 237.834 Td /F1 9.8 Tf  [(Ralf Marquard, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 218.429 Td /F1 9.8 Tf  [(Tina Raab, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 199.024 Td /F1 9.8 Tf  [(Caroline Schrenk, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 179.619 Td /F1 9.8 Tf  [(Michele Schuierer, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 160.215 Td /F1 9.8 Tf  [(Alexandra Wiedemann, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 140.810 Td /F1 9.8 Tf  [(Antonie Beister, Taufkirchen, Germany)] TJ ET
BT 26.250 121.405 Td /F1 9.8 Tf  [(Matthias Dose, Taufkirchen, Germany)] TJ ET
BT 26.250 102.000 Td /F1 9.8 Tf  [(Kathrin Hammer, Taufkirchen, Germany)] TJ ET
BT 26.250 82.596 Td /F1 9.8 Tf  [(Gabriele Leythaeuser, Taufkirchen, Germany)] TJ ET
BT 26.250 63.191 Td /F1 9.8 Tf  [(Ralf Marquard, Taufkirchen, Germany)] TJ ET
Q
q
15.000 33.905 577.500 743.095 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(Cornelius J. Werner, Universit�tsklinikum Aachen, Neurologische Klinik, Germany)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(Herwig Lange, Reha Zentrum in Dinslaken im Gesundheitszentrums Lang, Dinslake, Germany)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Matthias L�hle, Universit�tsklinikum Carl Gustav Carus an der Technischen Universit�t Dresden, Klinik und Poliklinik f�r )] TJ ET
BT 26.250 716.762 Td /F1 9.8 Tf  [(Neurologie, Dresden, Germany)] TJ ET
BT 26.250 697.357 Td /F1 9.8 Tf  [(Alexander Storch, Universit�tsklinikum Carl Gustav Carus an der Technischen Universit�t Dresden, Klinik und Poliklinik f�r )] TJ ET
BT 26.250 685.452 Td /F1 9.8 Tf  [(Neurologie, Dresden, Germany)] TJ ET
BT 26.250 666.048 Td /F1 9.8 Tf  [(Anett Wolz, Universit�tsklinikum Carl Gustav Carus an der Technischen Universit�t Dresden, Klinik und Poliklinik f�r )] TJ ET
BT 26.250 654.143 Td /F1 9.8 Tf  [(Neurologie, Dresden, Germany)] TJ ET
BT 26.250 634.738 Td /F1 9.8 Tf  [(Martin Wolz, Universit�tsklinikum Carl Gustav Carus an der Technischen Universit�t Dresden, Klinik und Poliklinik f�r )] TJ ET
BT 26.250 622.833 Td /F1 9.8 Tf  [(Neurologie, Dresden, Germany)] TJ ET
BT 26.250 603.429 Td /F1 9.8 Tf  [(Johann Lambeck, Universit�tsklinik Freiburg, Neurologie, Freiburg, Germany)] TJ ET
BT 26.250 584.024 Td /F1 9.8 Tf  [(Birgit Zucker, Universit�tsklinik Freiburg, Neurologie, Freiburg, Germany)] TJ ET
BT 26.250 564.619 Td /F1 9.8 Tf  [(Alexander M�nchau, Universit�tsklinikum Hamburg-Eppendorf, Klinik und Poliklinik f�r Neurologie, Hamburg, Germany)] TJ ET
BT 26.250 545.214 Td /F1 9.8 Tf  [(Lars Stubbe, Universit�tsklinikum Hamburg-Eppendorf, Klinik und Poliklinik f�r Neurologie, Hamburg, Germany)] TJ ET
BT 26.250 525.810 Td /F1 9.8 Tf  [(Simone Zittel, Universit�tsklinikum Hamburg-Eppendorf, Klinik und Poliklinik f�r Neurologie, Hamburg, Germany)] TJ ET
BT 26.250 506.405 Td /F1 9.8 Tf  [(Walburgis Heinicke, Psychatrium Heiligenhafen, Germany)] TJ ET
BT 26.250 487.000 Td /F1 9.8 Tf  [(Bernhard Longinus, Klinik f�r Psychiatrie und Psychotherapie Marburg-S�d, Germany)] TJ ET
BT 26.250 467.595 Td /F1 9.8 Tf  [(Alexander Peinemann, Huntington-Ambulanz im Neuro-Kopfzentrum � Klinikum rechts der Isar der Neurologischen Klinik und )] TJ ET
BT 26.250 455.691 Td /F1 9.8 Tf  [(Poliklinik der Technischen Universit�t M�nchen, Germany)] TJ ET
BT 26.250 436.286 Td /F1 9.8 Tf  [(Michael St�dtler, Huntington-Ambulanz im Neuro-Kopfzentrum � Klinikum rechts der Isar der Neurologischen Klinik und )] TJ ET
BT 26.250 424.381 Td /F1 9.8 Tf  [(Poliklinik der Technischen Universit�t M�nchen, Germany)] TJ ET
BT 26.250 404.976 Td /F1 9.8 Tf  [(Adolf Weindl, Huntington-Ambulanz im Neuro-Kopfzentrum � Klinikum rechts der Isar der Neurologischen Klinik und Poliklinik )] TJ ET
BT 26.250 393.072 Td /F1 9.8 Tf  [(der Technischen Universit�t M�nchen, Germany)] TJ ET
BT 26.250 373.667 Td /F1 9.8 Tf  [(Stefan Bohlen, Universit�tsklinikum M�nster, Klinik und Poliklinik f�r Neurologie, M�nster, Germany)] TJ ET
BT 26.250 354.262 Td /F1 9.8 Tf  [(Herwig Lange, Universit�tsklinikum M�nster, Klinik und Poliklinik f�r Neurologie, M�nster, Germany)] TJ ET
BT 26.250 334.857 Td /F1 9.8 Tf  [(Ralf Reilmann, Universit�tsklinikum M�nster, Klinik und Poliklinik f�r Neurologie, M�nster, Germany)] TJ ET
BT 26.250 315.453 Td /F1 9.8 Tf  [(Antonie Beister, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 296.048 Td /F1 9.8 Tf  [(Matthias Dose, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 276.643 Td /F1 9.8 Tf  [(Kathrin Hammer, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 257.238 Td /F1 9.8 Tf  [(Gabriele Leythaeuser, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 237.834 Td /F1 9.8 Tf  [(Ralf Marquard, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 218.429 Td /F1 9.8 Tf  [(Tina Raab, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 199.024 Td /F1 9.8 Tf  [(Caroline Schrenk, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 179.619 Td /F1 9.8 Tf  [(Michele Schuierer, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 160.215 Td /F1 9.8 Tf  [(Alexandra Wiedemann, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 140.810 Td /F1 9.8 Tf  [(Antonie Beister, Taufkirchen, Germany)] TJ ET
BT 26.250 121.405 Td /F1 9.8 Tf  [(Matthias Dose, Taufkirchen, Germany)] TJ ET
BT 26.250 102.000 Td /F1 9.8 Tf  [(Kathrin Hammer, Taufkirchen, Germany)] TJ ET
BT 26.250 82.596 Td /F1 9.8 Tf  [(Gabriele Leythaeuser, Taufkirchen, Germany)] TJ ET
BT 26.250 63.191 Td /F1 9.8 Tf  [(Ralf Marquard, Taufkirchen, Germany)] TJ ET
Q
q
15.000 33.905 577.500 743.095 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(Cornelius J. Werner, Universit�tsklinikum Aachen, Neurologische Klinik, Germany)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(Herwig Lange, Reha Zentrum in Dinslaken im Gesundheitszentrums Lang, Dinslake, Germany)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Matthias L�hle, Universit�tsklinikum Carl Gustav Carus an der Technischen Universit�t Dresden, Klinik und Poliklinik f�r )] TJ ET
BT 26.250 716.762 Td /F1 9.8 Tf  [(Neurologie, Dresden, Germany)] TJ ET
BT 26.250 697.357 Td /F1 9.8 Tf  [(Alexander Storch, Universit�tsklinikum Carl Gustav Carus an der Technischen Universit�t Dresden, Klinik und Poliklinik f�r )] TJ ET
BT 26.250 685.452 Td /F1 9.8 Tf  [(Neurologie, Dresden, Germany)] TJ ET
BT 26.250 666.048 Td /F1 9.8 Tf  [(Anett Wolz, Universit�tsklinikum Carl Gustav Carus an der Technischen Universit�t Dresden, Klinik und Poliklinik f�r )] TJ ET
BT 26.250 654.143 Td /F1 9.8 Tf  [(Neurologie, Dresden, Germany)] TJ ET
BT 26.250 634.738 Td /F1 9.8 Tf  [(Martin Wolz, Universit�tsklinikum Carl Gustav Carus an der Technischen Universit�t Dresden, Klinik und Poliklinik f�r )] TJ ET
BT 26.250 622.833 Td /F1 9.8 Tf  [(Neurologie, Dresden, Germany)] TJ ET
BT 26.250 603.429 Td /F1 9.8 Tf  [(Johann Lambeck, Universit�tsklinik Freiburg, Neurologie, Freiburg, Germany)] TJ ET
BT 26.250 584.024 Td /F1 9.8 Tf  [(Birgit Zucker, Universit�tsklinik Freiburg, Neurologie, Freiburg, Germany)] TJ ET
BT 26.250 564.619 Td /F1 9.8 Tf  [(Alexander M�nchau, Universit�tsklinikum Hamburg-Eppendorf, Klinik und Poliklinik f�r Neurologie, Hamburg, Germany)] TJ ET
BT 26.250 545.214 Td /F1 9.8 Tf  [(Lars Stubbe, Universit�tsklinikum Hamburg-Eppendorf, Klinik und Poliklinik f�r Neurologie, Hamburg, Germany)] TJ ET
BT 26.250 525.810 Td /F1 9.8 Tf  [(Simone Zittel, Universit�tsklinikum Hamburg-Eppendorf, Klinik und Poliklinik f�r Neurologie, Hamburg, Germany)] TJ ET
BT 26.250 506.405 Td /F1 9.8 Tf  [(Walburgis Heinicke, Psychatrium Heiligenhafen, Germany)] TJ ET
BT 26.250 487.000 Td /F1 9.8 Tf  [(Bernhard Longinus, Klinik f�r Psychiatrie und Psychotherapie Marburg-S�d, Germany)] TJ ET
BT 26.250 467.595 Td /F1 9.8 Tf  [(Alexander Peinemann, Huntington-Ambulanz im Neuro-Kopfzentrum � Klinikum rechts der Isar der Neurologischen Klinik und )] TJ ET
BT 26.250 455.691 Td /F1 9.8 Tf  [(Poliklinik der Technischen Universit�t M�nchen, Germany)] TJ ET
BT 26.250 436.286 Td /F1 9.8 Tf  [(Michael St�dtler, Huntington-Ambulanz im Neuro-Kopfzentrum � Klinikum rechts der Isar der Neurologischen Klinik und )] TJ ET
BT 26.250 424.381 Td /F1 9.8 Tf  [(Poliklinik der Technischen Universit�t M�nchen, Germany)] TJ ET
BT 26.250 404.976 Td /F1 9.8 Tf  [(Adolf Weindl, Huntington-Ambulanz im Neuro-Kopfzentrum � Klinikum rechts der Isar der Neurologischen Klinik und Poliklinik )] TJ ET
BT 26.250 393.072 Td /F1 9.8 Tf  [(der Technischen Universit�t M�nchen, Germany)] TJ ET
BT 26.250 373.667 Td /F1 9.8 Tf  [(Stefan Bohlen, Universit�tsklinikum M�nster, Klinik und Poliklinik f�r Neurologie, M�nster, Germany)] TJ ET
BT 26.250 354.262 Td /F1 9.8 Tf  [(Herwig Lange, Universit�tsklinikum M�nster, Klinik und Poliklinik f�r Neurologie, M�nster, Germany)] TJ ET
BT 26.250 334.857 Td /F1 9.8 Tf  [(Ralf Reilmann, Universit�tsklinikum M�nster, Klinik und Poliklinik f�r Neurologie, M�nster, Germany)] TJ ET
BT 26.250 315.453 Td /F1 9.8 Tf  [(Antonie Beister, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 296.048 Td /F1 9.8 Tf  [(Matthias Dose, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 276.643 Td /F1 9.8 Tf  [(Kathrin Hammer, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 257.238 Td /F1 9.8 Tf  [(Gabriele Leythaeuser, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 237.834 Td /F1 9.8 Tf  [(Ralf Marquard, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 218.429 Td /F1 9.8 Tf  [(Tina Raab, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 199.024 Td /F1 9.8 Tf  [(Caroline Schrenk, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 179.619 Td /F1 9.8 Tf  [(Michele Schuierer, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 160.215 Td /F1 9.8 Tf  [(Alexandra Wiedemann, Isar-Amper-Klinikum � Klinik Taufkirchen \(Vils\), Germany)] TJ ET
BT 26.250 140.810 Td /F1 9.8 Tf  [(Antonie Beister, Taufkirchen, Germany)] TJ ET
BT 26.250 121.405 Td /F1 9.8 Tf  [(Matthias Dose, Taufkirchen, Germany)] TJ ET
BT 26.250 102.000 Td /F1 9.8 Tf  [(Kathrin Hammer, Taufkirchen, Germany)] TJ ET
BT 26.250 82.596 Td /F1 9.8 Tf  [(Gabriele Leythaeuser, Taufkirchen, Germany)] TJ ET
BT 26.250 63.191 Td /F1 9.8 Tf  [(Ralf Marquard, Taufkirchen, Germany)] TJ ET
Q
q
0.000 0.000 0.000 rg
BT 291.710 19.825 Td /F1 11.0 Tf  [(6)] TJ ET
BT 25.000 19.825 Td /F1 11.0 Tf  [(PLOS Currents Huntington Disease)] TJ ET

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<< /Type /Page
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>>
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152 0 obj
<<
/Length 15385 >>
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0.271 0.267 0.267 rg
q
15.000 27.715 577.500 749.285 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(Tina Raab, Taufkirchen, Germany)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(Caroline Schrenk, Taufkirchen, Germany)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Michele Schuierer, Taufkirchen, Germany)] TJ ET
BT 26.250 709.262 Td /F1 9.8 Tf  [(Alexandra Wiedemann, Taufkirchen, Germany)] TJ ET
BT 26.250 689.857 Td /F1 9.8 Tf  [(Daniel Ecker, Universit�tsklinikum Ulm, Neurologie, Ulm, Germany)] TJ ET
BT 26.250 670.452 Td /F1 9.8 Tf  [(Carolin Eschenbach, Universit�tsklinikum Ulm, Neurologie, Ulm, Germany)] TJ ET
BT 26.250 651.048 Td /F1 9.8 Tf  [(Bernhard Landwehrmeyer, Universit�tsklinikum Ulm, Neurologie, Ulm, Germany)] TJ ET
BT 26.250 631.643 Td /F1 9.8 Tf  [(Franziska Lezius, Universit�tsklinikum Ulm, Neurologie, Ulm, Germany)] TJ ET
BT 26.250 612.238 Td /F1 9.8 Tf  [(Michael Orth, Universit�tsklinikum Ulm, Neurologie, Ulm, Germany)] TJ ET
BT 26.250 592.833 Td /F1 9.8 Tf  [(Sonja Trautmann, Universit�tsklinikum Ulm, Neurologie, Ulm, Germany)] TJ ET
BT 26.250 573.429 Td /F1 9.8 Tf  [(Claudia Cormio, Dipartimento di Scienze Neurologiche e Psichiatriche Universita� di Bari, Italy)] TJ ET
BT 26.250 554.024 Td /F1 9.8 Tf  [(Olimpia Difruscolo, Dipartimento di Scienze Neurologiche e Psichiatriche Universita� di Bari, Italy)] TJ ET
BT 26.250 534.619 Td /F1 9.8 Tf  [(Marina de Tommaso, Dipartimento di Scienze Neurologiche e Psichiatriche Universita� di Bari, Italy)] TJ ET
BT 26.250 515.214 Td /F1 9.8 Tf  [(Vittorio Sciruicchio, Dipartimento di Scienze Neurologiche e Psichiatriche Universita� di Bari, Italy)] TJ ET
BT 26.250 495.810 Td /F1 9.8 Tf  [(Claudia Serpino, Dipartimento di Scienze Neurologiche e Psichiatriche Universita� di Bari, Italy)] TJ ET
BT 26.250 476.405 Td /F1 9.8 Tf  [(Elisabetta Bertini, Neurologia I- Unita� di Neurogenetica Departimento di Neurologia e Psichiatria, Universita� di Firenze, Italy)] TJ ET
BT 26.250 457.000 Td /F1 9.8 Tf  [(Claudia Mechi, Neurologia I- Unita� di Neurogenetica Departimento di Neurologia e Psichiatria, Universita� di Firenze, Italy)] TJ ET
BT 26.250 437.595 Td /F1 9.8 Tf  [(Marco Paganini, Neurologia I- Unita� di Neurogenetica Departimento di Neurologia e Psichiatria, Universita� di Firenze, Italy)] TJ ET
BT 26.250 418.191 Td /F1 9.8 Tf  [(Sivia Piacentini, Neurologia I- Unita� di Neurogenetica Departimento di Neurologia e Psichiatria, Universita� di Firenze, Italy)] TJ ET
BT 26.250 398.786 Td /F1 9.8 Tf  [(Maria Romoli, Neurologia I- Unita� di Neurogenetica Departimento di Neurologia e Psichiatria, Universita� di Firenze, Italy)] TJ ET
BT 26.250 379.381 Td /F1 9.8 Tf  [(Sandro Sorbi, Neurologia I- Unita� di Neurogenetica Departimento di Neurologia e Psichiatria, Universita� di Firenze, Italy)] TJ ET
BT 26.250 359.976 Td /F1 9.8 Tf  [(Giovanni Abbruzzese, Dipartimento di Neuroscienze, Oftalmologia e Genetica \(DiNOG\), Universit� di Genova, Italy)] TJ ET
BT 26.250 340.572 Td /F1 9.8 Tf  [(Emilio Di Maria, Dipartimento di Neuroscienze, Oftalmologia e Genetica \(DiNOG\), Universit� di Genova, Italy)] TJ ET
BT 26.250 321.167 Td /F1 9.8 Tf  [(Monica Bandettini di Poggio Giovanna Ferrandes, Dipartimento di Neuroscienze, Oftalmologia e Genetica \(DiNOG\), Universit� )] TJ ET
BT 26.250 309.262 Td /F1 9.8 Tf  [(di Genova, Italy)] TJ ET
BT 26.250 289.857 Td /F1 9.8 Tf  [(Paola Mandich, Dipartimento di Neuroscienze, Oftalmologia e Genetica \(DiNOG\), Universit� di Genova, Italy)] TJ ET
BT 26.250 270.453 Td /F1 9.8 Tf  [(Roberta Marchese, Dipartimento di Neuroscienze, Oftalmologia e Genetica \(DiNOG\), Universit� di Genova, Italy)] TJ ET
BT 26.250 251.048 Td /F1 9.8 Tf  [(Alberto Albanese, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy)] TJ ET
BT 26.250 231.643 Td /F1 9.8 Tf  [(Stefano Di Donato, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy)] TJ ET
BT 26.250 212.238 Td /F1 9.8 Tf  [(Caterina Mariotti, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy)] TJ ET
BT 26.250 192.834 Td /F1 9.8 Tf  [(Paola Soliveri, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy)] TJ ET
BT 26.250 173.429 Td /F1 9.8 Tf  [(Cinzia Gellera, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy)] TJ ET
BT 26.250 154.024 Td /F1 9.8 Tf  [(Daniela Monza, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy)] TJ ET
BT 26.250 134.619 Td /F1 9.8 Tf  [(Chiara Tomasello, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy)] TJ ET
BT 26.250 115.215 Td /F1 9.8 Tf  [(Lorenzo Nanetti, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy)] TJ ET
BT 26.250 95.810 Td /F1 9.8 Tf  [(Di Maio Luigi, Azienda Ospedaliera Universitaria Federico II � Dipartimento di Scienze Neurologiche, Naples, Italy)] TJ ET
BT 26.250 76.405 Td /F1 9.8 Tf  [(Giuseppe De Michele, Azienda Ospedaliera Universitaria Federico II � Dipartimento di Scienze Neurologiche, Naples, Italy)] TJ ET
BT 26.250 57.000 Td /F1 9.8 Tf  [(Carlo Rinaldi, Azienda Ospedaliera Universitaria Federico II � Dipartimento di Scienze Neurologiche, Naples, Italy)] TJ ET
Q
q
15.000 27.715 577.500 749.285 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(Tina Raab, Taufkirchen, Germany)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(Caroline Schrenk, Taufkirchen, Germany)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Michele Schuierer, Taufkirchen, Germany)] TJ ET
BT 26.250 709.262 Td /F1 9.8 Tf  [(Alexandra Wiedemann, Taufkirchen, Germany)] TJ ET
BT 26.250 689.857 Td /F1 9.8 Tf  [(Daniel Ecker, Universit�tsklinikum Ulm, Neurologie, Ulm, Germany)] TJ ET
BT 26.250 670.452 Td /F1 9.8 Tf  [(Carolin Eschenbach, Universit�tsklinikum Ulm, Neurologie, Ulm, Germany)] TJ ET
BT 26.250 651.048 Td /F1 9.8 Tf  [(Bernhard Landwehrmeyer, Universit�tsklinikum Ulm, Neurologie, Ulm, Germany)] TJ ET
BT 26.250 631.643 Td /F1 9.8 Tf  [(Franziska Lezius, Universit�tsklinikum Ulm, Neurologie, Ulm, Germany)] TJ ET
BT 26.250 612.238 Td /F1 9.8 Tf  [(Michael Orth, Universit�tsklinikum Ulm, Neurologie, Ulm, Germany)] TJ ET
BT 26.250 592.833 Td /F1 9.8 Tf  [(Sonja Trautmann, Universit�tsklinikum Ulm, Neurologie, Ulm, Germany)] TJ ET
BT 26.250 573.429 Td /F1 9.8 Tf  [(Claudia Cormio, Dipartimento di Scienze Neurologiche e Psichiatriche Universita� di Bari, Italy)] TJ ET
BT 26.250 554.024 Td /F1 9.8 Tf  [(Olimpia Difruscolo, Dipartimento di Scienze Neurologiche e Psichiatriche Universita� di Bari, Italy)] TJ ET
BT 26.250 534.619 Td /F1 9.8 Tf  [(Marina de Tommaso, Dipartimento di Scienze Neurologiche e Psichiatriche Universita� di Bari, Italy)] TJ ET
BT 26.250 515.214 Td /F1 9.8 Tf  [(Vittorio Sciruicchio, Dipartimento di Scienze Neurologiche e Psichiatriche Universita� di Bari, Italy)] TJ ET
BT 26.250 495.810 Td /F1 9.8 Tf  [(Claudia Serpino, Dipartimento di Scienze Neurologiche e Psichiatriche Universita� di Bari, Italy)] TJ ET
BT 26.250 476.405 Td /F1 9.8 Tf  [(Elisabetta Bertini, Neurologia I- Unita� di Neurogenetica Departimento di Neurologia e Psichiatria, Universita� di Firenze, Italy)] TJ ET
BT 26.250 457.000 Td /F1 9.8 Tf  [(Claudia Mechi, Neurologia I- Unita� di Neurogenetica Departimento di Neurologia e Psichiatria, Universita� di Firenze, Italy)] TJ ET
BT 26.250 437.595 Td /F1 9.8 Tf  [(Marco Paganini, Neurologia I- Unita� di Neurogenetica Departimento di Neurologia e Psichiatria, Universita� di Firenze, Italy)] TJ ET
BT 26.250 418.191 Td /F1 9.8 Tf  [(Sivia Piacentini, Neurologia I- Unita� di Neurogenetica Departimento di Neurologia e Psichiatria, Universita� di Firenze, Italy)] TJ ET
BT 26.250 398.786 Td /F1 9.8 Tf  [(Maria Romoli, Neurologia I- Unita� di Neurogenetica Departimento di Neurologia e Psichiatria, Universita� di Firenze, Italy)] TJ ET
BT 26.250 379.381 Td /F1 9.8 Tf  [(Sandro Sorbi, Neurologia I- Unita� di Neurogenetica Departimento di Neurologia e Psichiatria, Universita� di Firenze, Italy)] TJ ET
BT 26.250 359.976 Td /F1 9.8 Tf  [(Giovanni Abbruzzese, Dipartimento di Neuroscienze, Oftalmologia e Genetica \(DiNOG\), Universit� di Genova, Italy)] TJ ET
BT 26.250 340.572 Td /F1 9.8 Tf  [(Emilio Di Maria, Dipartimento di Neuroscienze, Oftalmologia e Genetica \(DiNOG\), Universit� di Genova, Italy)] TJ ET
BT 26.250 321.167 Td /F1 9.8 Tf  [(Monica Bandettini di Poggio Giovanna Ferrandes, Dipartimento di Neuroscienze, Oftalmologia e Genetica \(DiNOG\), Universit� )] TJ ET
BT 26.250 309.262 Td /F1 9.8 Tf  [(di Genova, Italy)] TJ ET
BT 26.250 289.857 Td /F1 9.8 Tf  [(Paola Mandich, Dipartimento di Neuroscienze, Oftalmologia e Genetica \(DiNOG\), Universit� di Genova, Italy)] TJ ET
BT 26.250 270.453 Td /F1 9.8 Tf  [(Roberta Marchese, Dipartimento di Neuroscienze, Oftalmologia e Genetica \(DiNOG\), Universit� di Genova, Italy)] TJ ET
BT 26.250 251.048 Td /F1 9.8 Tf  [(Alberto Albanese, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy)] TJ ET
BT 26.250 231.643 Td /F1 9.8 Tf  [(Stefano Di Donato, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy)] TJ ET
BT 26.250 212.238 Td /F1 9.8 Tf  [(Caterina Mariotti, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy)] TJ ET
BT 26.250 192.834 Td /F1 9.8 Tf  [(Paola Soliveri, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy)] TJ ET
BT 26.250 173.429 Td /F1 9.8 Tf  [(Cinzia Gellera, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy)] TJ ET
BT 26.250 154.024 Td /F1 9.8 Tf  [(Daniela Monza, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy)] TJ ET
BT 26.250 134.619 Td /F1 9.8 Tf  [(Chiara Tomasello, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy)] TJ ET
BT 26.250 115.215 Td /F1 9.8 Tf  [(Lorenzo Nanetti, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy)] TJ ET
BT 26.250 95.810 Td /F1 9.8 Tf  [(Di Maio Luigi, Azienda Ospedaliera Universitaria Federico II � Dipartimento di Scienze Neurologiche, Naples, Italy)] TJ ET
BT 26.250 76.405 Td /F1 9.8 Tf  [(Giuseppe De Michele, Azienda Ospedaliera Universitaria Federico II � Dipartimento di Scienze Neurologiche, Naples, Italy)] TJ ET
BT 26.250 57.000 Td /F1 9.8 Tf  [(Carlo Rinaldi, Azienda Ospedaliera Universitaria Federico II � Dipartimento di Scienze Neurologiche, Naples, Italy)] TJ ET
Q
q
15.000 27.715 577.500 749.285 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(Tina Raab, Taufkirchen, Germany)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(Caroline Schrenk, Taufkirchen, Germany)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Michele Schuierer, Taufkirchen, Germany)] TJ ET
BT 26.250 709.262 Td /F1 9.8 Tf  [(Alexandra Wiedemann, Taufkirchen, Germany)] TJ ET
BT 26.250 689.857 Td /F1 9.8 Tf  [(Daniel Ecker, Universit�tsklinikum Ulm, Neurologie, Ulm, Germany)] TJ ET
BT 26.250 670.452 Td /F1 9.8 Tf  [(Carolin Eschenbach, Universit�tsklinikum Ulm, Neurologie, Ulm, Germany)] TJ ET
BT 26.250 651.048 Td /F1 9.8 Tf  [(Bernhard Landwehrmeyer, Universit�tsklinikum Ulm, Neurologie, Ulm, Germany)] TJ ET
BT 26.250 631.643 Td /F1 9.8 Tf  [(Franziska Lezius, Universit�tsklinikum Ulm, Neurologie, Ulm, Germany)] TJ ET
BT 26.250 612.238 Td /F1 9.8 Tf  [(Michael Orth, Universit�tsklinikum Ulm, Neurologie, Ulm, Germany)] TJ ET
BT 26.250 592.833 Td /F1 9.8 Tf  [(Sonja Trautmann, Universit�tsklinikum Ulm, Neurologie, Ulm, Germany)] TJ ET
BT 26.250 573.429 Td /F1 9.8 Tf  [(Claudia Cormio, Dipartimento di Scienze Neurologiche e Psichiatriche Universita� di Bari, Italy)] TJ ET
BT 26.250 554.024 Td /F1 9.8 Tf  [(Olimpia Difruscolo, Dipartimento di Scienze Neurologiche e Psichiatriche Universita� di Bari, Italy)] TJ ET
BT 26.250 534.619 Td /F1 9.8 Tf  [(Marina de Tommaso, Dipartimento di Scienze Neurologiche e Psichiatriche Universita� di Bari, Italy)] TJ ET
BT 26.250 515.214 Td /F1 9.8 Tf  [(Vittorio Sciruicchio, Dipartimento di Scienze Neurologiche e Psichiatriche Universita� di Bari, Italy)] TJ ET
BT 26.250 495.810 Td /F1 9.8 Tf  [(Claudia Serpino, Dipartimento di Scienze Neurologiche e Psichiatriche Universita� di Bari, Italy)] TJ ET
BT 26.250 476.405 Td /F1 9.8 Tf  [(Elisabetta Bertini, Neurologia I- Unita� di Neurogenetica Departimento di Neurologia e Psichiatria, Universita� di Firenze, Italy)] TJ ET
BT 26.250 457.000 Td /F1 9.8 Tf  [(Claudia Mechi, Neurologia I- Unita� di Neurogenetica Departimento di Neurologia e Psichiatria, Universita� di Firenze, Italy)] TJ ET
BT 26.250 437.595 Td /F1 9.8 Tf  [(Marco Paganini, Neurologia I- Unita� di Neurogenetica Departimento di Neurologia e Psichiatria, Universita� di Firenze, Italy)] TJ ET
BT 26.250 418.191 Td /F1 9.8 Tf  [(Sivia Piacentini, Neurologia I- Unita� di Neurogenetica Departimento di Neurologia e Psichiatria, Universita� di Firenze, Italy)] TJ ET
BT 26.250 398.786 Td /F1 9.8 Tf  [(Maria Romoli, Neurologia I- Unita� di Neurogenetica Departimento di Neurologia e Psichiatria, Universita� di Firenze, Italy)] TJ ET
BT 26.250 379.381 Td /F1 9.8 Tf  [(Sandro Sorbi, Neurologia I- Unita� di Neurogenetica Departimento di Neurologia e Psichiatria, Universita� di Firenze, Italy)] TJ ET
BT 26.250 359.976 Td /F1 9.8 Tf  [(Giovanni Abbruzzese, Dipartimento di Neuroscienze, Oftalmologia e Genetica \(DiNOG\), Universit� di Genova, Italy)] TJ ET
BT 26.250 340.572 Td /F1 9.8 Tf  [(Emilio Di Maria, Dipartimento di Neuroscienze, Oftalmologia e Genetica \(DiNOG\), Universit� di Genova, Italy)] TJ ET
BT 26.250 321.167 Td /F1 9.8 Tf  [(Monica Bandettini di Poggio Giovanna Ferrandes, Dipartimento di Neuroscienze, Oftalmologia e Genetica \(DiNOG\), Universit� )] TJ ET
BT 26.250 309.262 Td /F1 9.8 Tf  [(di Genova, Italy)] TJ ET
BT 26.250 289.857 Td /F1 9.8 Tf  [(Paola Mandich, Dipartimento di Neuroscienze, Oftalmologia e Genetica \(DiNOG\), Universit� di Genova, Italy)] TJ ET
BT 26.250 270.453 Td /F1 9.8 Tf  [(Roberta Marchese, Dipartimento di Neuroscienze, Oftalmologia e Genetica \(DiNOG\), Universit� di Genova, Italy)] TJ ET
BT 26.250 251.048 Td /F1 9.8 Tf  [(Alberto Albanese, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy)] TJ ET
BT 26.250 231.643 Td /F1 9.8 Tf  [(Stefano Di Donato, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy)] TJ ET
BT 26.250 212.238 Td /F1 9.8 Tf  [(Caterina Mariotti, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy)] TJ ET
BT 26.250 192.834 Td /F1 9.8 Tf  [(Paola Soliveri, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy)] TJ ET
BT 26.250 173.429 Td /F1 9.8 Tf  [(Cinzia Gellera, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy)] TJ ET
BT 26.250 154.024 Td /F1 9.8 Tf  [(Daniela Monza, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy)] TJ ET
BT 26.250 134.619 Td /F1 9.8 Tf  [(Chiara Tomasello, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy)] TJ ET
BT 26.250 115.215 Td /F1 9.8 Tf  [(Lorenzo Nanetti, Fondazione IRCCS Istituto Neurologico C. Besta, Milan, Italy)] TJ ET
BT 26.250 95.810 Td /F1 9.8 Tf  [(Di Maio Luigi, Azienda Ospedaliera Universitaria Federico II � Dipartimento di Scienze Neurologiche, Naples, Italy)] TJ ET
BT 26.250 76.405 Td /F1 9.8 Tf  [(Giuseppe De Michele, Azienda Ospedaliera Universitaria Federico II � Dipartimento di Scienze Neurologiche, Naples, Italy)] TJ ET
BT 26.250 57.000 Td /F1 9.8 Tf  [(Carlo Rinaldi, Azienda Ospedaliera Universitaria Federico II � Dipartimento di Scienze Neurologiche, Naples, Italy)] TJ ET
Q
q
0.000 0.000 0.000 rg
BT 291.710 19.825 Td /F1 11.0 Tf  [(7)] TJ ET
BT 25.000 19.825 Td /F1 11.0 Tf  [(PLOS Currents Huntington Disease)] TJ ET

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0.271 0.267 0.267 rg
q
15.000 32.596 577.500 744.404 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(Cinzia Russo, Azienda Ospedaliera Universitaria Federico II � Dipartimento di Scienze Neurologiche, Naples, Italy)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(Elena Salvatore, Azienda Ospedaliera Universitaria Federico II � Dipartimento di Scienze Neurologiche, Naples, Italy)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Tecla Tucci, Azienda Ospedaliera Universitaria Federico II � Dipartimento di Scienze Neurologiche, Naples, Italy)] TJ ET
BT 26.250 709.262 Td /F1 9.8 Tf  [(Ferdinando Squitieri, Neurogenetics Unit � IRCCS Neuromed, Pozzilli , Italy)] TJ ET
BT 26.250 689.857 Td /F1 9.8 Tf  [(Tiziana Martino, Neurogenetics Unit � IRCCS Neuromed, Pozzilli , Italy)] TJ ET
BT 26.250 670.452 Td /F1 9.8 Tf  [(Sara Orobello, Neurogenetics Unit � IRCCS Neuromed, Pozzilli , Italy)] TJ ET
BT 26.250 651.048 Td /F1 9.8 Tf  [(Silvia Alberti, Neurogenetics Unit � IRCCS Neuromed, Pozzilli , Italy)] TJ ET
BT 26.250 631.643 Td /F1 9.8 Tf  [(Francesca De Gregorio, Neurogenetics Unit � IRCCS Neuromed, Pozzilli , Italy)] TJ ET
BT 26.250 612.238 Td /F1 9.8 Tf  [(Valentina Codella, Neurogenetics Unit � IRCCS Neuromed, Pozzilli , Italy)] TJ ET
BT 26.250 592.833 Td /F1 9.8 Tf  [(Nunzia De Nicola, Neurogenetics Unit � IRCCS Neuromed, Pozzilli , Italy)] TJ ET
BT 26.250 573.429 Td /F1 9.8 Tf  [(Vittorio Maglione, Neurogenetics Unit � IRCCS Neuromed, Pozzilli , Italy)] TJ ET
BT 26.250 554.024 Td /F1 9.8 Tf  [(Anna Rita Bentivoglio, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di )] TJ ET
BT 26.250 542.119 Td /F1 9.8 Tf  [(Neuroscienze/ CNR Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 522.714 Td /F1 9.8 Tf  [(Alfonso Fasano, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ )] TJ ET
BT 26.250 510.810 Td /F1 9.8 Tf  [(CNR Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 491.405 Td /F1 9.8 Tf  [(Marina Frontali, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ CNR )] TJ ET
BT 26.250 479.500 Td /F1 9.8 Tf  [(Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 460.095 Td /F1 9.8 Tf  [(Arianna Guidubaldi, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ )] TJ ET
BT 26.250 448.191 Td /F1 9.8 Tf  [(CNR Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 428.786 Td /F1 9.8 Tf  [(Tamara Ialongo, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ )] TJ ET
BT 26.250 416.881 Td /F1 9.8 Tf  [(CNR Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 397.476 Td /F1 9.8 Tf  [(Gioia Jacopini, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ CNR )] TJ ET
BT 26.250 385.572 Td /F1 9.8 Tf  [(Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 366.167 Td /F1 9.8 Tf  [(Giovanna Loria, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ CNR )] TJ ET
BT 26.250 354.262 Td /F1 9.8 Tf  [(Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 334.857 Td /F1 9.8 Tf  [(Carla Piano, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ CNR )] TJ ET
BT 26.250 322.953 Td /F1 9.8 Tf  [(Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 303.548 Td /F1 9.8 Tf  [(Silvia Romano, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ CNR )] TJ ET
BT 26.250 291.643 Td /F1 9.8 Tf  [(Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 272.238 Td /F1 9.8 Tf  [(Francesco Soleti, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ )] TJ ET
BT 26.250 260.334 Td /F1 9.8 Tf  [(CNR Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 240.929 Td /F1 9.8 Tf  [(Maria Spadaro, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ CNR )] TJ ET
BT 26.250 229.024 Td /F1 9.8 Tf  [(Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 209.619 Td /F1 9.8 Tf  [(Paola Zinzi , Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ CNR )] TJ ET
BT 26.250 197.715 Td /F1 9.8 Tf  [(Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 178.310 Td /F1 9.8 Tf  [(Arvid Heiberg, Rikshospitalet, Dept. of Medical Genetics, Oslo-RH, Norway)] TJ ET
BT 26.250 158.905 Td /F1 9.8 Tf  [(Marleen R van Walsem, Rikshospitalet, Dept. of Medical Genetics, Oslo-RH, Norway)] TJ ET
BT 26.250 139.500 Td /F1 9.8 Tf  [(Kathrine Bj�rgo, Ullev�l University Hospital, Oslo, Norway)] TJ ET
BT 26.250 120.096 Td /F1 9.8 Tf  [(Madelein Fannemel, Ullev�l University Hospital, Oslo, Norway)] TJ ET
BT 26.250 100.691 Td /F1 9.8 Tf  [(Per G�rvell, Ullev�l University Hospital, Oslo, Norway)] TJ ET
BT 26.250 81.286 Td /F1 9.8 Tf  [(Lars Retterst�l, Ullev�l University Hospital, Oslo, Norway)] TJ ET
BT 26.250 61.881 Td /F1 9.8 Tf  [(Inga Bj�rnevoll, St. Olavs Hospital, Trondheim , Norway)] TJ ET
Q
q
15.000 32.596 577.500 744.404 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(Cinzia Russo, Azienda Ospedaliera Universitaria Federico II � Dipartimento di Scienze Neurologiche, Naples, Italy)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(Elena Salvatore, Azienda Ospedaliera Universitaria Federico II � Dipartimento di Scienze Neurologiche, Naples, Italy)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Tecla Tucci, Azienda Ospedaliera Universitaria Federico II � Dipartimento di Scienze Neurologiche, Naples, Italy)] TJ ET
BT 26.250 709.262 Td /F1 9.8 Tf  [(Ferdinando Squitieri, Neurogenetics Unit � IRCCS Neuromed, Pozzilli , Italy)] TJ ET
BT 26.250 689.857 Td /F1 9.8 Tf  [(Tiziana Martino, Neurogenetics Unit � IRCCS Neuromed, Pozzilli , Italy)] TJ ET
BT 26.250 670.452 Td /F1 9.8 Tf  [(Sara Orobello, Neurogenetics Unit � IRCCS Neuromed, Pozzilli , Italy)] TJ ET
BT 26.250 651.048 Td /F1 9.8 Tf  [(Silvia Alberti, Neurogenetics Unit � IRCCS Neuromed, Pozzilli , Italy)] TJ ET
BT 26.250 631.643 Td /F1 9.8 Tf  [(Francesca De Gregorio, Neurogenetics Unit � IRCCS Neuromed, Pozzilli , Italy)] TJ ET
BT 26.250 612.238 Td /F1 9.8 Tf  [(Valentina Codella, Neurogenetics Unit � IRCCS Neuromed, Pozzilli , Italy)] TJ ET
BT 26.250 592.833 Td /F1 9.8 Tf  [(Nunzia De Nicola, Neurogenetics Unit � IRCCS Neuromed, Pozzilli , Italy)] TJ ET
BT 26.250 573.429 Td /F1 9.8 Tf  [(Vittorio Maglione, Neurogenetics Unit � IRCCS Neuromed, Pozzilli , Italy)] TJ ET
BT 26.250 554.024 Td /F1 9.8 Tf  [(Anna Rita Bentivoglio, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di )] TJ ET
BT 26.250 542.119 Td /F1 9.8 Tf  [(Neuroscienze/ CNR Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 522.714 Td /F1 9.8 Tf  [(Alfonso Fasano, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ )] TJ ET
BT 26.250 510.810 Td /F1 9.8 Tf  [(CNR Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 491.405 Td /F1 9.8 Tf  [(Marina Frontali, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ CNR )] TJ ET
BT 26.250 479.500 Td /F1 9.8 Tf  [(Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 460.095 Td /F1 9.8 Tf  [(Arianna Guidubaldi, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ )] TJ ET
BT 26.250 448.191 Td /F1 9.8 Tf  [(CNR Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 428.786 Td /F1 9.8 Tf  [(Tamara Ialongo, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ )] TJ ET
BT 26.250 416.881 Td /F1 9.8 Tf  [(CNR Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 397.476 Td /F1 9.8 Tf  [(Gioia Jacopini, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ CNR )] TJ ET
BT 26.250 385.572 Td /F1 9.8 Tf  [(Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 366.167 Td /F1 9.8 Tf  [(Giovanna Loria, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ CNR )] TJ ET
BT 26.250 354.262 Td /F1 9.8 Tf  [(Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 334.857 Td /F1 9.8 Tf  [(Carla Piano, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ CNR )] TJ ET
BT 26.250 322.953 Td /F1 9.8 Tf  [(Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 303.548 Td /F1 9.8 Tf  [(Silvia Romano, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ CNR )] TJ ET
BT 26.250 291.643 Td /F1 9.8 Tf  [(Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 272.238 Td /F1 9.8 Tf  [(Francesco Soleti, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ )] TJ ET
BT 26.250 260.334 Td /F1 9.8 Tf  [(CNR Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 240.929 Td /F1 9.8 Tf  [(Maria Spadaro, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ CNR )] TJ ET
BT 26.250 229.024 Td /F1 9.8 Tf  [(Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 209.619 Td /F1 9.8 Tf  [(Paola Zinzi , Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ CNR )] TJ ET
BT 26.250 197.715 Td /F1 9.8 Tf  [(Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 178.310 Td /F1 9.8 Tf  [(Arvid Heiberg, Rikshospitalet, Dept. of Medical Genetics, Oslo-RH, Norway)] TJ ET
BT 26.250 158.905 Td /F1 9.8 Tf  [(Marleen R van Walsem, Rikshospitalet, Dept. of Medical Genetics, Oslo-RH, Norway)] TJ ET
BT 26.250 139.500 Td /F1 9.8 Tf  [(Kathrine Bj�rgo, Ullev�l University Hospital, Oslo, Norway)] TJ ET
BT 26.250 120.096 Td /F1 9.8 Tf  [(Madelein Fannemel, Ullev�l University Hospital, Oslo, Norway)] TJ ET
BT 26.250 100.691 Td /F1 9.8 Tf  [(Per G�rvell, Ullev�l University Hospital, Oslo, Norway)] TJ ET
BT 26.250 81.286 Td /F1 9.8 Tf  [(Lars Retterst�l, Ullev�l University Hospital, Oslo, Norway)] TJ ET
BT 26.250 61.881 Td /F1 9.8 Tf  [(Inga Bj�rnevoll, St. Olavs Hospital, Trondheim , Norway)] TJ ET
Q
q
15.000 32.596 577.500 744.404 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(Cinzia Russo, Azienda Ospedaliera Universitaria Federico II � Dipartimento di Scienze Neurologiche, Naples, Italy)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(Elena Salvatore, Azienda Ospedaliera Universitaria Federico II � Dipartimento di Scienze Neurologiche, Naples, Italy)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Tecla Tucci, Azienda Ospedaliera Universitaria Federico II � Dipartimento di Scienze Neurologiche, Naples, Italy)] TJ ET
BT 26.250 709.262 Td /F1 9.8 Tf  [(Ferdinando Squitieri, Neurogenetics Unit � IRCCS Neuromed, Pozzilli , Italy)] TJ ET
BT 26.250 689.857 Td /F1 9.8 Tf  [(Tiziana Martino, Neurogenetics Unit � IRCCS Neuromed, Pozzilli , Italy)] TJ ET
BT 26.250 670.452 Td /F1 9.8 Tf  [(Sara Orobello, Neurogenetics Unit � IRCCS Neuromed, Pozzilli , Italy)] TJ ET
BT 26.250 651.048 Td /F1 9.8 Tf  [(Silvia Alberti, Neurogenetics Unit � IRCCS Neuromed, Pozzilli , Italy)] TJ ET
BT 26.250 631.643 Td /F1 9.8 Tf  [(Francesca De Gregorio, Neurogenetics Unit � IRCCS Neuromed, Pozzilli , Italy)] TJ ET
BT 26.250 612.238 Td /F1 9.8 Tf  [(Valentina Codella, Neurogenetics Unit � IRCCS Neuromed, Pozzilli , Italy)] TJ ET
BT 26.250 592.833 Td /F1 9.8 Tf  [(Nunzia De Nicola, Neurogenetics Unit � IRCCS Neuromed, Pozzilli , Italy)] TJ ET
BT 26.250 573.429 Td /F1 9.8 Tf  [(Vittorio Maglione, Neurogenetics Unit � IRCCS Neuromed, Pozzilli , Italy)] TJ ET
BT 26.250 554.024 Td /F1 9.8 Tf  [(Anna Rita Bentivoglio, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di )] TJ ET
BT 26.250 542.119 Td /F1 9.8 Tf  [(Neuroscienze/ CNR Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 522.714 Td /F1 9.8 Tf  [(Alfonso Fasano, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ )] TJ ET
BT 26.250 510.810 Td /F1 9.8 Tf  [(CNR Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 491.405 Td /F1 9.8 Tf  [(Marina Frontali, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ CNR )] TJ ET
BT 26.250 479.500 Td /F1 9.8 Tf  [(Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 460.095 Td /F1 9.8 Tf  [(Arianna Guidubaldi, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ )] TJ ET
BT 26.250 448.191 Td /F1 9.8 Tf  [(CNR Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 428.786 Td /F1 9.8 Tf  [(Tamara Ialongo, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ )] TJ ET
BT 26.250 416.881 Td /F1 9.8 Tf  [(CNR Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 397.476 Td /F1 9.8 Tf  [(Gioia Jacopini, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ CNR )] TJ ET
BT 26.250 385.572 Td /F1 9.8 Tf  [(Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 366.167 Td /F1 9.8 Tf  [(Giovanna Loria, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ CNR )] TJ ET
BT 26.250 354.262 Td /F1 9.8 Tf  [(Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 334.857 Td /F1 9.8 Tf  [(Carla Piano, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ CNR )] TJ ET
BT 26.250 322.953 Td /F1 9.8 Tf  [(Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 303.548 Td /F1 9.8 Tf  [(Silvia Romano, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ CNR )] TJ ET
BT 26.250 291.643 Td /F1 9.8 Tf  [(Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 272.238 Td /F1 9.8 Tf  [(Francesco Soleti, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ )] TJ ET
BT 26.250 260.334 Td /F1 9.8 Tf  [(CNR Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 240.929 Td /F1 9.8 Tf  [(Maria Spadaro, Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ CNR )] TJ ET
BT 26.250 229.024 Td /F1 9.8 Tf  [(Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 209.619 Td /F1 9.8 Tf  [(Paola Zinzi , Istituto di Neurobiologia e Medicina Molecolare CNR/ Istituto di Neurologia, Dipartimento di Neuroscienze/ CNR )] TJ ET
BT 26.250 197.715 Td /F1 9.8 Tf  [(Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy)] TJ ET
BT 26.250 178.310 Td /F1 9.8 Tf  [(Arvid Heiberg, Rikshospitalet, Dept. of Medical Genetics, Oslo-RH, Norway)] TJ ET
BT 26.250 158.905 Td /F1 9.8 Tf  [(Marleen R van Walsem, Rikshospitalet, Dept. of Medical Genetics, Oslo-RH, Norway)] TJ ET
BT 26.250 139.500 Td /F1 9.8 Tf  [(Kathrine Bj�rgo, Ullev�l University Hospital, Oslo, Norway)] TJ ET
BT 26.250 120.096 Td /F1 9.8 Tf  [(Madelein Fannemel, Ullev�l University Hospital, Oslo, Norway)] TJ ET
BT 26.250 100.691 Td /F1 9.8 Tf  [(Per G�rvell, Ullev�l University Hospital, Oslo, Norway)] TJ ET
BT 26.250 81.286 Td /F1 9.8 Tf  [(Lars Retterst�l, Ullev�l University Hospital, Oslo, Norway)] TJ ET
BT 26.250 61.881 Td /F1 9.8 Tf  [(Inga Bj�rnevoll, St. Olavs Hospital, Trondheim , Norway)] TJ ET
Q
q
0.000 0.000 0.000 rg
BT 291.710 19.825 Td /F1 11.0 Tf  [(8)] TJ ET
BT 25.000 19.825 Td /F1 11.0 Tf  [(PLOS Currents Huntington Disease)] TJ ET

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0.271 0.267 0.267 rg
q
15.000 39.619 577.500 737.381 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(Sigrid Botne Sando, St. Olavs Hospital, Trondheim , Norway)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(Jaroslaw Slawek, Specialistic Hospital, Gdansk Zaspa, Gdansk, Poland)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Witold Soltan, Specialistic Hospital, Gdansk Zaspa, Gdansk, Poland)] TJ ET
BT 26.250 709.262 Td /F1 9.8 Tf  [(Emilia Sitek, Specialistic Hospital, Gdansk Zaspa, Gdansk, Poland)] TJ ET
BT 26.250 689.857 Td /F1 9.8 Tf  [(Magdalena Boczarska-Jedynak, Silesian Medical University Katowice, Poland)] TJ ET
BT 26.250 670.452 Td /F1 9.8 Tf  [(Barbara Jasinska-Myga, Silesian Medical University Katowice, Poland)] TJ ET
BT 26.250 651.048 Td /F1 9.8 Tf  [(Gregorz Opala, Silesian Medical University Katowice, Poland)] TJ ET
BT 26.250 631.643 Td /F1 9.8 Tf  [(Andrzej Szczudlik, Krakowska Akademia Neurologii, Krakow, Poland)] TJ ET
BT 26.250 612.238 Td /F1 9.8 Tf  [(Monika Rudzi?ska, Krakowska Akademia Neurologii, Krakow, Poland)] TJ ET
BT 26.250 592.833 Td /F1 9.8 Tf  [(Magdalena W�jcik, Krakowska Akademia Neurologii, Krakow, Poland)] TJ ET
BT 26.250 573.429 Td /F1 9.8 Tf  [(Krzysztof Banaszkiewicz, Krakowska Akademia Neurologii, Krakow, Poland)] TJ ET
BT 26.250 554.024 Td /F1 9.8 Tf  [(Malgorzata Krawczyk, Krakowska Akademia Neurologii, Krakow, Poland)] TJ ET
BT 26.250 534.619 Td /F1 9.8 Tf  [(Daniel Zielonka, Medical University of Pozna?, Poland)] TJ ET
BT 26.250 515.214 Td /F1 9.8 Tf  [(Jerzy Marcinkowski, Medical University of Pozna?, Poland)] TJ ET
BT 26.250 495.810 Td /F1 9.8 Tf  [(Anna Ciesielska, Medical University of Pozna?, Poland)] TJ ET
BT 26.250 476.405 Td /F1 9.8 Tf  [(Justyna Sempo?owicz, Medical University of Pozna?, Poland)] TJ ET
BT 26.250 457.000 Td /F1 9.8 Tf  [(Anna Bryl, Medical University of Pozna?, Poland)] TJ ET
BT 26.250 437.595 Td /F1 9.8 Tf  [(Aneta Klimberg, Medical University of Pozna?, Poland)] TJ ET
BT 26.250 418.191 Td /F1 9.8 Tf  [(Piotr Janik, Medical University of Warsaw, Neurology, Warsaw-MU, Poland)] TJ ET
BT 26.250 398.786 Td /F1 9.8 Tf  [(Anna Kalbarczyk, Medical University of Warsaw, Neurology, Warsaw-MU, Poland)] TJ ET
BT 26.250 379.381 Td /F1 9.8 Tf  [(Hubert Kwiecinski, Medical University of Warsaw, Neurology, Warsaw-MU, Poland)] TJ ET
BT 26.250 359.976 Td /F1 9.8 Tf  [(Zygmunt Jamrozik, Medical University of Warsaw, Neurology, Warsaw-MU, Poland)] TJ ET
BT 26.250 340.572 Td /F1 9.8 Tf  [(Grzegorz Witkowski, Institute of Psychiatry and Neurology Dep. of Genetics, Dep. of Neurology, Warsaw-IPiN, Poland)] TJ ET
BT 26.250 321.167 Td /F1 9.8 Tf  [(Danuta Ryglewicz, Institute of Psychiatry and Neurology Dep. of Genetics, Dep. of Neurology, Warsaw-IPiN, Poland)] TJ ET
BT 26.250 301.762 Td /F1 9.8 Tf  [(Jakub Antczak, Institute of Psychiatry and Neurology Dep. of Genetics, Dep. of Neurology, Warsaw-IPiN, Poland)] TJ ET
BT 26.250 282.357 Td /F1 9.8 Tf  [(Maria Rakowicz, Institute of Psychiatry and Neurology Dep. of Genetics, Dep. of Neurology, Warsaw-IPiN, Poland)] TJ ET
BT 26.250 262.953 Td /F1 9.8 Tf  [(Katarzyna Jachinska, Institute of Psychiatry and Neurology Dep. of Genetics, Dep. of Neurology, Warsaw-IPiN, Poland)] TJ ET
BT 26.250 243.548 Td /F1 9.8 Tf  [(Elzbieta Zdzienicka, Institute of Psychiatry and Neurology Dep. of Genetics, Dep. of Neurology, Warsaw-IPiN, Poland)] TJ ET
BT 26.250 224.143 Td /F1 9.8 Tf  [(Przemyslaw Richter, Institute of Psychiatry and Neurology Dep. of Genetics, Dep. of Neurology, Warsaw-IPiN, Poland)] TJ ET
BT 26.250 204.738 Td /F1 9.8 Tf  [(Jacek Zaremba, Institute of Psychiatry and Neurology Dep. of Genetics, Dep. of Neurology, Warsaw-IPiN, Poland)] TJ ET
BT 26.250 185.334 Td /F1 9.8 Tf  [(Miguel Coelho, Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon-Santa Maria, Portugal)] TJ ET
BT 26.250 165.929 Td /F1 9.8 Tf  [(Joaquim J Ferreira, Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon-Santa Maria, Portugal)] TJ ET
BT 26.250 146.524 Td /F1 9.8 Tf  [(Tiago Mestre, Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon-Santa Maria, Portugal)] TJ ET
BT 26.250 127.119 Td /F1 9.8 Tf  [(M�rio M Rosa, Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon-Santa Maria, Portugal)] TJ ET
BT 26.250 107.715 Td /F1 9.8 Tf  [(Anabela Valadas, Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon-Santa Maria, Portugal)] TJ ET
BT 26.250 88.310 Td /F1 9.8 Tf  [(Miguel Gago, Hospital S�o Jo�o E.P.E., Porto-S�o Jo�o, Portugal)] TJ ET
BT 26.250 68.905 Td /F1 9.8 Tf  [(Carolina Garrett, Hospital S�o Jo�o E.P.E., Porto-S�o Jo�o, Portugal)] TJ ET
BT 26.250 49.500 Td /F1 9.8 Tf  [(Maria Rosalia Guerra, Hospital S�o Jo�o E.P.E., Porto-S�o Jo�o, Portugal)] TJ ET
Q
q
15.000 39.619 577.500 737.381 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(Sigrid Botne Sando, St. Olavs Hospital, Trondheim , Norway)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(Jaroslaw Slawek, Specialistic Hospital, Gdansk Zaspa, Gdansk, Poland)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Witold Soltan, Specialistic Hospital, Gdansk Zaspa, Gdansk, Poland)] TJ ET
BT 26.250 709.262 Td /F1 9.8 Tf  [(Emilia Sitek, Specialistic Hospital, Gdansk Zaspa, Gdansk, Poland)] TJ ET
BT 26.250 689.857 Td /F1 9.8 Tf  [(Magdalena Boczarska-Jedynak, Silesian Medical University Katowice, Poland)] TJ ET
BT 26.250 670.452 Td /F1 9.8 Tf  [(Barbara Jasinska-Myga, Silesian Medical University Katowice, Poland)] TJ ET
BT 26.250 651.048 Td /F1 9.8 Tf  [(Gregorz Opala, Silesian Medical University Katowice, Poland)] TJ ET
BT 26.250 631.643 Td /F1 9.8 Tf  [(Andrzej Szczudlik, Krakowska Akademia Neurologii, Krakow, Poland)] TJ ET
BT 26.250 612.238 Td /F1 9.8 Tf  [(Monika Rudzi?ska, Krakowska Akademia Neurologii, Krakow, Poland)] TJ ET
BT 26.250 592.833 Td /F1 9.8 Tf  [(Magdalena W�jcik, Krakowska Akademia Neurologii, Krakow, Poland)] TJ ET
BT 26.250 573.429 Td /F1 9.8 Tf  [(Krzysztof Banaszkiewicz, Krakowska Akademia Neurologii, Krakow, Poland)] TJ ET
BT 26.250 554.024 Td /F1 9.8 Tf  [(Malgorzata Krawczyk, Krakowska Akademia Neurologii, Krakow, Poland)] TJ ET
BT 26.250 534.619 Td /F1 9.8 Tf  [(Daniel Zielonka, Medical University of Pozna?, Poland)] TJ ET
BT 26.250 515.214 Td /F1 9.8 Tf  [(Jerzy Marcinkowski, Medical University of Pozna?, Poland)] TJ ET
BT 26.250 495.810 Td /F1 9.8 Tf  [(Anna Ciesielska, Medical University of Pozna?, Poland)] TJ ET
BT 26.250 476.405 Td /F1 9.8 Tf  [(Justyna Sempo?owicz, Medical University of Pozna?, Poland)] TJ ET
BT 26.250 457.000 Td /F1 9.8 Tf  [(Anna Bryl, Medical University of Pozna?, Poland)] TJ ET
BT 26.250 437.595 Td /F1 9.8 Tf  [(Aneta Klimberg, Medical University of Pozna?, Poland)] TJ ET
BT 26.250 418.191 Td /F1 9.8 Tf  [(Piotr Janik, Medical University of Warsaw, Neurology, Warsaw-MU, Poland)] TJ ET
BT 26.250 398.786 Td /F1 9.8 Tf  [(Anna Kalbarczyk, Medical University of Warsaw, Neurology, Warsaw-MU, Poland)] TJ ET
BT 26.250 379.381 Td /F1 9.8 Tf  [(Hubert Kwiecinski, Medical University of Warsaw, Neurology, Warsaw-MU, Poland)] TJ ET
BT 26.250 359.976 Td /F1 9.8 Tf  [(Zygmunt Jamrozik, Medical University of Warsaw, Neurology, Warsaw-MU, Poland)] TJ ET
BT 26.250 340.572 Td /F1 9.8 Tf  [(Grzegorz Witkowski, Institute of Psychiatry and Neurology Dep. of Genetics, Dep. of Neurology, Warsaw-IPiN, Poland)] TJ ET
BT 26.250 321.167 Td /F1 9.8 Tf  [(Danuta Ryglewicz, Institute of Psychiatry and Neurology Dep. of Genetics, Dep. of Neurology, Warsaw-IPiN, Poland)] TJ ET
BT 26.250 301.762 Td /F1 9.8 Tf  [(Jakub Antczak, Institute of Psychiatry and Neurology Dep. of Genetics, Dep. of Neurology, Warsaw-IPiN, Poland)] TJ ET
BT 26.250 282.357 Td /F1 9.8 Tf  [(Maria Rakowicz, Institute of Psychiatry and Neurology Dep. of Genetics, Dep. of Neurology, Warsaw-IPiN, Poland)] TJ ET
BT 26.250 262.953 Td /F1 9.8 Tf  [(Katarzyna Jachinska, Institute of Psychiatry and Neurology Dep. of Genetics, Dep. of Neurology, Warsaw-IPiN, Poland)] TJ ET
BT 26.250 243.548 Td /F1 9.8 Tf  [(Elzbieta Zdzienicka, Institute of Psychiatry and Neurology Dep. of Genetics, Dep. of Neurology, Warsaw-IPiN, Poland)] TJ ET
BT 26.250 224.143 Td /F1 9.8 Tf  [(Przemyslaw Richter, Institute of Psychiatry and Neurology Dep. of Genetics, Dep. of Neurology, Warsaw-IPiN, Poland)] TJ ET
BT 26.250 204.738 Td /F1 9.8 Tf  [(Jacek Zaremba, Institute of Psychiatry and Neurology Dep. of Genetics, Dep. of Neurology, Warsaw-IPiN, Poland)] TJ ET
BT 26.250 185.334 Td /F1 9.8 Tf  [(Miguel Coelho, Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon-Santa Maria, Portugal)] TJ ET
BT 26.250 165.929 Td /F1 9.8 Tf  [(Joaquim J Ferreira, Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon-Santa Maria, Portugal)] TJ ET
BT 26.250 146.524 Td /F1 9.8 Tf  [(Tiago Mestre, Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon-Santa Maria, Portugal)] TJ ET
BT 26.250 127.119 Td /F1 9.8 Tf  [(M�rio M Rosa, Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon-Santa Maria, Portugal)] TJ ET
BT 26.250 107.715 Td /F1 9.8 Tf  [(Anabela Valadas, Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon-Santa Maria, Portugal)] TJ ET
BT 26.250 88.310 Td /F1 9.8 Tf  [(Miguel Gago, Hospital S�o Jo�o E.P.E., Porto-S�o Jo�o, Portugal)] TJ ET
BT 26.250 68.905 Td /F1 9.8 Tf  [(Carolina Garrett, Hospital S�o Jo�o E.P.E., Porto-S�o Jo�o, Portugal)] TJ ET
BT 26.250 49.500 Td /F1 9.8 Tf  [(Maria Rosalia Guerra, Hospital S�o Jo�o E.P.E., Porto-S�o Jo�o, Portugal)] TJ ET
Q
q
15.000 39.619 577.500 737.381 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(Sigrid Botne Sando, St. Olavs Hospital, Trondheim , Norway)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(Jaroslaw Slawek, Specialistic Hospital, Gdansk Zaspa, Gdansk, Poland)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Witold Soltan, Specialistic Hospital, Gdansk Zaspa, Gdansk, Poland)] TJ ET
BT 26.250 709.262 Td /F1 9.8 Tf  [(Emilia Sitek, Specialistic Hospital, Gdansk Zaspa, Gdansk, Poland)] TJ ET
BT 26.250 689.857 Td /F1 9.8 Tf  [(Magdalena Boczarska-Jedynak, Silesian Medical University Katowice, Poland)] TJ ET
BT 26.250 670.452 Td /F1 9.8 Tf  [(Barbara Jasinska-Myga, Silesian Medical University Katowice, Poland)] TJ ET
BT 26.250 651.048 Td /F1 9.8 Tf  [(Gregorz Opala, Silesian Medical University Katowice, Poland)] TJ ET
BT 26.250 631.643 Td /F1 9.8 Tf  [(Andrzej Szczudlik, Krakowska Akademia Neurologii, Krakow, Poland)] TJ ET
BT 26.250 612.238 Td /F1 9.8 Tf  [(Monika Rudzi?ska, Krakowska Akademia Neurologii, Krakow, Poland)] TJ ET
BT 26.250 592.833 Td /F1 9.8 Tf  [(Magdalena W�jcik, Krakowska Akademia Neurologii, Krakow, Poland)] TJ ET
BT 26.250 573.429 Td /F1 9.8 Tf  [(Krzysztof Banaszkiewicz, Krakowska Akademia Neurologii, Krakow, Poland)] TJ ET
BT 26.250 554.024 Td /F1 9.8 Tf  [(Malgorzata Krawczyk, Krakowska Akademia Neurologii, Krakow, Poland)] TJ ET
BT 26.250 534.619 Td /F1 9.8 Tf  [(Daniel Zielonka, Medical University of Pozna?, Poland)] TJ ET
BT 26.250 515.214 Td /F1 9.8 Tf  [(Jerzy Marcinkowski, Medical University of Pozna?, Poland)] TJ ET
BT 26.250 495.810 Td /F1 9.8 Tf  [(Anna Ciesielska, Medical University of Pozna?, Poland)] TJ ET
BT 26.250 476.405 Td /F1 9.8 Tf  [(Justyna Sempo?owicz, Medical University of Pozna?, Poland)] TJ ET
BT 26.250 457.000 Td /F1 9.8 Tf  [(Anna Bryl, Medical University of Pozna?, Poland)] TJ ET
BT 26.250 437.595 Td /F1 9.8 Tf  [(Aneta Klimberg, Medical University of Pozna?, Poland)] TJ ET
BT 26.250 418.191 Td /F1 9.8 Tf  [(Piotr Janik, Medical University of Warsaw, Neurology, Warsaw-MU, Poland)] TJ ET
BT 26.250 398.786 Td /F1 9.8 Tf  [(Anna Kalbarczyk, Medical University of Warsaw, Neurology, Warsaw-MU, Poland)] TJ ET
BT 26.250 379.381 Td /F1 9.8 Tf  [(Hubert Kwiecinski, Medical University of Warsaw, Neurology, Warsaw-MU, Poland)] TJ ET
BT 26.250 359.976 Td /F1 9.8 Tf  [(Zygmunt Jamrozik, Medical University of Warsaw, Neurology, Warsaw-MU, Poland)] TJ ET
BT 26.250 340.572 Td /F1 9.8 Tf  [(Grzegorz Witkowski, Institute of Psychiatry and Neurology Dep. of Genetics, Dep. of Neurology, Warsaw-IPiN, Poland)] TJ ET
BT 26.250 321.167 Td /F1 9.8 Tf  [(Danuta Ryglewicz, Institute of Psychiatry and Neurology Dep. of Genetics, Dep. of Neurology, Warsaw-IPiN, Poland)] TJ ET
BT 26.250 301.762 Td /F1 9.8 Tf  [(Jakub Antczak, Institute of Psychiatry and Neurology Dep. of Genetics, Dep. of Neurology, Warsaw-IPiN, Poland)] TJ ET
BT 26.250 282.357 Td /F1 9.8 Tf  [(Maria Rakowicz, Institute of Psychiatry and Neurology Dep. of Genetics, Dep. of Neurology, Warsaw-IPiN, Poland)] TJ ET
BT 26.250 262.953 Td /F1 9.8 Tf  [(Katarzyna Jachinska, Institute of Psychiatry and Neurology Dep. of Genetics, Dep. of Neurology, Warsaw-IPiN, Poland)] TJ ET
BT 26.250 243.548 Td /F1 9.8 Tf  [(Elzbieta Zdzienicka, Institute of Psychiatry and Neurology Dep. of Genetics, Dep. of Neurology, Warsaw-IPiN, Poland)] TJ ET
BT 26.250 224.143 Td /F1 9.8 Tf  [(Przemyslaw Richter, Institute of Psychiatry and Neurology Dep. of Genetics, Dep. of Neurology, Warsaw-IPiN, Poland)] TJ ET
BT 26.250 204.738 Td /F1 9.8 Tf  [(Jacek Zaremba, Institute of Psychiatry and Neurology Dep. of Genetics, Dep. of Neurology, Warsaw-IPiN, Poland)] TJ ET
BT 26.250 185.334 Td /F1 9.8 Tf  [(Miguel Coelho, Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon-Santa Maria, Portugal)] TJ ET
BT 26.250 165.929 Td /F1 9.8 Tf  [(Joaquim J Ferreira, Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon-Santa Maria, Portugal)] TJ ET
BT 26.250 146.524 Td /F1 9.8 Tf  [(Tiago Mestre, Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon-Santa Maria, Portugal)] TJ ET
BT 26.250 127.119 Td /F1 9.8 Tf  [(M�rio M Rosa, Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon-Santa Maria, Portugal)] TJ ET
BT 26.250 107.715 Td /F1 9.8 Tf  [(Anabela Valadas, Neurological Clinical Research Unit, Institute of Molecular Medicine, Lisbon-Santa Maria, Portugal)] TJ ET
BT 26.250 88.310 Td /F1 9.8 Tf  [(Miguel Gago, Hospital S�o Jo�o E.P.E., Porto-S�o Jo�o, Portugal)] TJ ET
BT 26.250 68.905 Td /F1 9.8 Tf  [(Carolina Garrett, Hospital S�o Jo�o E.P.E., Porto-S�o Jo�o, Portugal)] TJ ET
BT 26.250 49.500 Td /F1 9.8 Tf  [(Maria Rosalia Guerra, Hospital S�o Jo�o E.P.E., Porto-S�o Jo�o, Portugal)] TJ ET
Q
q
0.000 0.000 0.000 rg
BT 291.710 19.825 Td /F1 11.0 Tf  [(9)] TJ ET
BT 25.000 19.825 Td /F1 11.0 Tf  [(PLOS Currents Huntington Disease)] TJ ET

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0.271 0.267 0.267 rg
q
15.000 39.619 577.500 737.381 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(Francisco J Barrero, Hospital Universitario San Cecilio, Neurolog�a, Granada, Spain)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(Blas Morales, Hospital Universitario San Cecilio, Neurolog�a, Granada, Spain)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Jos� Luis L�pez-Send�n Moreno, Hospital Universitario Ram�n y Cajal, Neurolog�a, Madrid, Spain)] TJ ET
BT 26.250 709.262 Td /F1 9.8 Tf  [(Esther Cubo, Servicio de Neurolog�a Hospital General Yag�e, Burgos, Spain)] TJ ET
BT 26.250 689.857 Td /F1 9.8 Tf  [(Natividad Mariscal, Servicio de Neurolog�a Hospital General Yag�e, Burgos, Spain)] TJ ET
BT 26.250 670.452 Td /F1 9.8 Tf  [(Jes�s S�nchez, Servicio de Neurolog�a Hospital General Yag�e, Burgos, Spain)] TJ ET
BT 26.250 651.048 Td /F1 9.8 Tf  [(Roc�o Garc�a-Ramos Garc�a, Hospital Cl�nico Universitario San Carlos, Madrid-Clinico, Spain)] TJ ET
BT 26.250 631.643 Td /F1 9.8 Tf  [(Clara Villanueva, Hospital Cl�nico Universitario San Carlos, Madrid-Clinico, Spain)] TJ ET
BT 26.250 612.238 Td /F1 9.8 Tf  [(Purificacion Pin Quiroga, Hospital Cl�nico Universitario San Carlos, Madrid-Clinico, Spain)] TJ ET
BT 26.250 592.833 Td /F1 9.8 Tf  [(M�nica Bascu�ana, Hospital Ram�n y Cajal, Neurolog�a, Madrid RYC, Spain)] TJ ET
BT 26.250 573.429 Td /F1 9.8 Tf  [(Patricia Trigo Cubillo, Hospital Ram�n y Cajal, Neurolog�a, Madrid RYC, Spain)] TJ ET
BT 26.250 554.024 Td /F1 9.8 Tf  [(Marta Fat�as, Hospital Ram�n y Cajal, Neurolog�a, Madrid RYC, Spain)] TJ ET
BT 26.250 534.619 Td /F1 9.8 Tf  [(Jos� Luis L�pez Moreno, Hospital Ram�n y Cajal, Neurolog�a, Madrid RYC, Spain)] TJ ET
BT 26.250 515.214 Td /F1 9.8 Tf  [(Guillermo Garc�a Ribas, Hospital Ram�n y Cajal, Neurolog�a, Madrid RYC, Spain)] TJ ET
BT 26.250 495.810 Td /F1 9.8 Tf  [(Christine Schwarz, Hospital Ram�n y Cajal, Neurolog�a, Madrid RYC, Spain)] TJ ET
BT 26.250 476.405 Td /F1 9.8 Tf  [(Justo Garc�a de Y�benes, Hospital Ram�n y Cajal, Neurolog�a, Madrid RYC, Spain)] TJ ET
BT 26.250 457.000 Td /F1 9.8 Tf  [(Mar�a Jos� Saiz Artiga, Madrid-Fundaci�n Jim�nez D�az, Madrid FJD, Spain)] TJ ET
BT 26.250 437.595 Td /F1 9.8 Tf  [(Asunci�n Mart�nez-Descals, Madrid-Fundaci�n Jim�nez D�az, Madrid FJD, Spain)] TJ ET
BT 26.250 418.191 Td /F1 9.8 Tf  [(Pedro J Garc�a Ru�z, Madrid-Fundaci�n Jim�nez D�az, Madrid FJD, Spain)] TJ ET
BT 26.250 398.786 Td /F1 9.8 Tf  [(Vicenta S�nchez, Madrid-Fundaci�n Jim�nez D�az, Madrid FJD, Spain)] TJ ET
BT 26.250 379.381 Td /F1 9.8 Tf  [(Lorenza Fortuna Alcaraz, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain)] TJ ET
BT 26.250 359.976 Td /F1 9.8 Tf  [(Mar�a Fuensanta Noguera Perea, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain)] TJ ET
BT 26.250 340.572 Td /F1 9.8 Tf  [(Mar�a Martirio Antequera Torres, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain)] TJ ET
BT 26.250 321.167 Td /F1 9.8 Tf  [(Laura Vivancos Moreau, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain)] TJ ET
BT 26.250 301.762 Td /F1 9.8 Tf  [(Ana Rojo Sebastian, Barcelona-Hospital M�tua de Terrassa, Spain)] TJ ET
BT 26.250 282.357 Td /F1 9.8 Tf  [(Miquel Aguilar Barbera, Barcelona-Hospital M�tua de Terrassa, Spain)] TJ ET
BT 26.250 262.953 Td /F1 9.8 Tf  [(Dolors Badenes Guia, Barcelona-Hospital M�tua de Terrassa, Spain)] TJ ET
BT 26.250 243.548 Td /F1 9.8 Tf  [(Laura Casas Hernanz, Barcelona-Hospital M�tua de Terrassa, Spain)] TJ ET
BT 26.250 224.143 Td /F1 9.8 Tf  [(Gemma Tome Carruesco, Barcelona-Hospital M�tua de Terrassa, Spain)] TJ ET
BT 26.250 204.738 Td /F1 9.8 Tf  [(Esther Suarez San Martin, Barcelona-Hospital M�tua de Terrassa, Spain)] TJ ET
BT 26.250 185.334 Td /F1 9.8 Tf  [(Judit L�pez Catena, Barcelona-Hospital M�tua de Terrassa, Spain)] TJ ET
BT 26.250 165.929 Td /F1 9.8 Tf  [(Jordi Bas, Hospital Universitari de Bellvitge, Barcelona-Bellvitge, Spain)] TJ ET
BT 26.250 146.524 Td /F1 9.8 Tf  [(Matilde Calopa, Hospital Universitari de Bellvitge, Barcelona-Bellvitge, Spain)] TJ ET
BT 26.250 127.119 Td /F1 9.8 Tf  [(N�ria Busquets, Hospital Universitari de Bellvitge, Barcelona-Bellvitge, Spain)] TJ ET
BT 26.250 107.715 Td /F1 9.8 Tf  [(Penelope Navas Arques, Hospital Son Dureta, Palma, Spain)] TJ ET
BT 26.250 88.310 Td /F1 9.8 Tf  [(Aranzaz� Gorospe, Hospital Son Dureta, Palma, Spain)] TJ ET
BT 26.250 68.905 Td /F1 9.8 Tf  [(In�s Legarda, Hospital Son Dureta, Palma, Spain)] TJ ET
BT 26.250 49.500 Td /F1 9.8 Tf  [(Mar�a Jos� Torres Rodr�guez, Hospital Son Dureta, Palma, Spain)] TJ ET
Q
q
15.000 39.619 577.500 737.381 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(Francisco J Barrero, Hospital Universitario San Cecilio, Neurolog�a, Granada, Spain)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(Blas Morales, Hospital Universitario San Cecilio, Neurolog�a, Granada, Spain)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Jos� Luis L�pez-Send�n Moreno, Hospital Universitario Ram�n y Cajal, Neurolog�a, Madrid, Spain)] TJ ET
BT 26.250 709.262 Td /F1 9.8 Tf  [(Esther Cubo, Servicio de Neurolog�a Hospital General Yag�e, Burgos, Spain)] TJ ET
BT 26.250 689.857 Td /F1 9.8 Tf  [(Natividad Mariscal, Servicio de Neurolog�a Hospital General Yag�e, Burgos, Spain)] TJ ET
BT 26.250 670.452 Td /F1 9.8 Tf  [(Jes�s S�nchez, Servicio de Neurolog�a Hospital General Yag�e, Burgos, Spain)] TJ ET
BT 26.250 651.048 Td /F1 9.8 Tf  [(Roc�o Garc�a-Ramos Garc�a, Hospital Cl�nico Universitario San Carlos, Madrid-Clinico, Spain)] TJ ET
BT 26.250 631.643 Td /F1 9.8 Tf  [(Clara Villanueva, Hospital Cl�nico Universitario San Carlos, Madrid-Clinico, Spain)] TJ ET
BT 26.250 612.238 Td /F1 9.8 Tf  [(Purificacion Pin Quiroga, Hospital Cl�nico Universitario San Carlos, Madrid-Clinico, Spain)] TJ ET
BT 26.250 592.833 Td /F1 9.8 Tf  [(M�nica Bascu�ana, Hospital Ram�n y Cajal, Neurolog�a, Madrid RYC, Spain)] TJ ET
BT 26.250 573.429 Td /F1 9.8 Tf  [(Patricia Trigo Cubillo, Hospital Ram�n y Cajal, Neurolog�a, Madrid RYC, Spain)] TJ ET
BT 26.250 554.024 Td /F1 9.8 Tf  [(Marta Fat�as, Hospital Ram�n y Cajal, Neurolog�a, Madrid RYC, Spain)] TJ ET
BT 26.250 534.619 Td /F1 9.8 Tf  [(Jos� Luis L�pez Moreno, Hospital Ram�n y Cajal, Neurolog�a, Madrid RYC, Spain)] TJ ET
BT 26.250 515.214 Td /F1 9.8 Tf  [(Guillermo Garc�a Ribas, Hospital Ram�n y Cajal, Neurolog�a, Madrid RYC, Spain)] TJ ET
BT 26.250 495.810 Td /F1 9.8 Tf  [(Christine Schwarz, Hospital Ram�n y Cajal, Neurolog�a, Madrid RYC, Spain)] TJ ET
BT 26.250 476.405 Td /F1 9.8 Tf  [(Justo Garc�a de Y�benes, Hospital Ram�n y Cajal, Neurolog�a, Madrid RYC, Spain)] TJ ET
BT 26.250 457.000 Td /F1 9.8 Tf  [(Mar�a Jos� Saiz Artiga, Madrid-Fundaci�n Jim�nez D�az, Madrid FJD, Spain)] TJ ET
BT 26.250 437.595 Td /F1 9.8 Tf  [(Asunci�n Mart�nez-Descals, Madrid-Fundaci�n Jim�nez D�az, Madrid FJD, Spain)] TJ ET
BT 26.250 418.191 Td /F1 9.8 Tf  [(Pedro J Garc�a Ru�z, Madrid-Fundaci�n Jim�nez D�az, Madrid FJD, Spain)] TJ ET
BT 26.250 398.786 Td /F1 9.8 Tf  [(Vicenta S�nchez, Madrid-Fundaci�n Jim�nez D�az, Madrid FJD, Spain)] TJ ET
BT 26.250 379.381 Td /F1 9.8 Tf  [(Lorenza Fortuna Alcaraz, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain)] TJ ET
BT 26.250 359.976 Td /F1 9.8 Tf  [(Mar�a Fuensanta Noguera Perea, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain)] TJ ET
BT 26.250 340.572 Td /F1 9.8 Tf  [(Mar�a Martirio Antequera Torres, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain)] TJ ET
BT 26.250 321.167 Td /F1 9.8 Tf  [(Laura Vivancos Moreau, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain)] TJ ET
BT 26.250 301.762 Td /F1 9.8 Tf  [(Ana Rojo Sebastian, Barcelona-Hospital M�tua de Terrassa, Spain)] TJ ET
BT 26.250 282.357 Td /F1 9.8 Tf  [(Miquel Aguilar Barbera, Barcelona-Hospital M�tua de Terrassa, Spain)] TJ ET
BT 26.250 262.953 Td /F1 9.8 Tf  [(Dolors Badenes Guia, Barcelona-Hospital M�tua de Terrassa, Spain)] TJ ET
BT 26.250 243.548 Td /F1 9.8 Tf  [(Laura Casas Hernanz, Barcelona-Hospital M�tua de Terrassa, Spain)] TJ ET
BT 26.250 224.143 Td /F1 9.8 Tf  [(Gemma Tome Carruesco, Barcelona-Hospital M�tua de Terrassa, Spain)] TJ ET
BT 26.250 204.738 Td /F1 9.8 Tf  [(Esther Suarez San Martin, Barcelona-Hospital M�tua de Terrassa, Spain)] TJ ET
BT 26.250 185.334 Td /F1 9.8 Tf  [(Judit L�pez Catena, Barcelona-Hospital M�tua de Terrassa, Spain)] TJ ET
BT 26.250 165.929 Td /F1 9.8 Tf  [(Jordi Bas, Hospital Universitari de Bellvitge, Barcelona-Bellvitge, Spain)] TJ ET
BT 26.250 146.524 Td /F1 9.8 Tf  [(Matilde Calopa, Hospital Universitari de Bellvitge, Barcelona-Bellvitge, Spain)] TJ ET
BT 26.250 127.119 Td /F1 9.8 Tf  [(N�ria Busquets, Hospital Universitari de Bellvitge, Barcelona-Bellvitge, Spain)] TJ ET
BT 26.250 107.715 Td /F1 9.8 Tf  [(Penelope Navas Arques, Hospital Son Dureta, Palma, Spain)] TJ ET
BT 26.250 88.310 Td /F1 9.8 Tf  [(Aranzaz� Gorospe, Hospital Son Dureta, Palma, Spain)] TJ ET
BT 26.250 68.905 Td /F1 9.8 Tf  [(In�s Legarda, Hospital Son Dureta, Palma, Spain)] TJ ET
BT 26.250 49.500 Td /F1 9.8 Tf  [(Mar�a Jos� Torres Rodr�guez, Hospital Son Dureta, Palma, Spain)] TJ ET
Q
q
15.000 39.619 577.500 737.381 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(Francisco J Barrero, Hospital Universitario San Cecilio, Neurolog�a, Granada, Spain)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(Blas Morales, Hospital Universitario San Cecilio, Neurolog�a, Granada, Spain)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Jos� Luis L�pez-Send�n Moreno, Hospital Universitario Ram�n y Cajal, Neurolog�a, Madrid, Spain)] TJ ET
BT 26.250 709.262 Td /F1 9.8 Tf  [(Esther Cubo, Servicio de Neurolog�a Hospital General Yag�e, Burgos, Spain)] TJ ET
BT 26.250 689.857 Td /F1 9.8 Tf  [(Natividad Mariscal, Servicio de Neurolog�a Hospital General Yag�e, Burgos, Spain)] TJ ET
BT 26.250 670.452 Td /F1 9.8 Tf  [(Jes�s S�nchez, Servicio de Neurolog�a Hospital General Yag�e, Burgos, Spain)] TJ ET
BT 26.250 651.048 Td /F1 9.8 Tf  [(Roc�o Garc�a-Ramos Garc�a, Hospital Cl�nico Universitario San Carlos, Madrid-Clinico, Spain)] TJ ET
BT 26.250 631.643 Td /F1 9.8 Tf  [(Clara Villanueva, Hospital Cl�nico Universitario San Carlos, Madrid-Clinico, Spain)] TJ ET
BT 26.250 612.238 Td /F1 9.8 Tf  [(Purificacion Pin Quiroga, Hospital Cl�nico Universitario San Carlos, Madrid-Clinico, Spain)] TJ ET
BT 26.250 592.833 Td /F1 9.8 Tf  [(M�nica Bascu�ana, Hospital Ram�n y Cajal, Neurolog�a, Madrid RYC, Spain)] TJ ET
BT 26.250 573.429 Td /F1 9.8 Tf  [(Patricia Trigo Cubillo, Hospital Ram�n y Cajal, Neurolog�a, Madrid RYC, Spain)] TJ ET
BT 26.250 554.024 Td /F1 9.8 Tf  [(Marta Fat�as, Hospital Ram�n y Cajal, Neurolog�a, Madrid RYC, Spain)] TJ ET
BT 26.250 534.619 Td /F1 9.8 Tf  [(Jos� Luis L�pez Moreno, Hospital Ram�n y Cajal, Neurolog�a, Madrid RYC, Spain)] TJ ET
BT 26.250 515.214 Td /F1 9.8 Tf  [(Guillermo Garc�a Ribas, Hospital Ram�n y Cajal, Neurolog�a, Madrid RYC, Spain)] TJ ET
BT 26.250 495.810 Td /F1 9.8 Tf  [(Christine Schwarz, Hospital Ram�n y Cajal, Neurolog�a, Madrid RYC, Spain)] TJ ET
BT 26.250 476.405 Td /F1 9.8 Tf  [(Justo Garc�a de Y�benes, Hospital Ram�n y Cajal, Neurolog�a, Madrid RYC, Spain)] TJ ET
BT 26.250 457.000 Td /F1 9.8 Tf  [(Mar�a Jos� Saiz Artiga, Madrid-Fundaci�n Jim�nez D�az, Madrid FJD, Spain)] TJ ET
BT 26.250 437.595 Td /F1 9.8 Tf  [(Asunci�n Mart�nez-Descals, Madrid-Fundaci�n Jim�nez D�az, Madrid FJD, Spain)] TJ ET
BT 26.250 418.191 Td /F1 9.8 Tf  [(Pedro J Garc�a Ru�z, Madrid-Fundaci�n Jim�nez D�az, Madrid FJD, Spain)] TJ ET
BT 26.250 398.786 Td /F1 9.8 Tf  [(Vicenta S�nchez, Madrid-Fundaci�n Jim�nez D�az, Madrid FJD, Spain)] TJ ET
BT 26.250 379.381 Td /F1 9.8 Tf  [(Lorenza Fortuna Alcaraz, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain)] TJ ET
BT 26.250 359.976 Td /F1 9.8 Tf  [(Mar�a Fuensanta Noguera Perea, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain)] TJ ET
BT 26.250 340.572 Td /F1 9.8 Tf  [(Mar�a Martirio Antequera Torres, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain)] TJ ET
BT 26.250 321.167 Td /F1 9.8 Tf  [(Laura Vivancos Moreau, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain)] TJ ET
BT 26.250 301.762 Td /F1 9.8 Tf  [(Ana Rojo Sebastian, Barcelona-Hospital M�tua de Terrassa, Spain)] TJ ET
BT 26.250 282.357 Td /F1 9.8 Tf  [(Miquel Aguilar Barbera, Barcelona-Hospital M�tua de Terrassa, Spain)] TJ ET
BT 26.250 262.953 Td /F1 9.8 Tf  [(Dolors Badenes Guia, Barcelona-Hospital M�tua de Terrassa, Spain)] TJ ET
BT 26.250 243.548 Td /F1 9.8 Tf  [(Laura Casas Hernanz, Barcelona-Hospital M�tua de Terrassa, Spain)] TJ ET
BT 26.250 224.143 Td /F1 9.8 Tf  [(Gemma Tome Carruesco, Barcelona-Hospital M�tua de Terrassa, Spain)] TJ ET
BT 26.250 204.738 Td /F1 9.8 Tf  [(Esther Suarez San Martin, Barcelona-Hospital M�tua de Terrassa, Spain)] TJ ET
BT 26.250 185.334 Td /F1 9.8 Tf  [(Judit L�pez Catena, Barcelona-Hospital M�tua de Terrassa, Spain)] TJ ET
BT 26.250 165.929 Td /F1 9.8 Tf  [(Jordi Bas, Hospital Universitari de Bellvitge, Barcelona-Bellvitge, Spain)] TJ ET
BT 26.250 146.524 Td /F1 9.8 Tf  [(Matilde Calopa, Hospital Universitari de Bellvitge, Barcelona-Bellvitge, Spain)] TJ ET
BT 26.250 127.119 Td /F1 9.8 Tf  [(N�ria Busquets, Hospital Universitari de Bellvitge, Barcelona-Bellvitge, Spain)] TJ ET
BT 26.250 107.715 Td /F1 9.8 Tf  [(Penelope Navas Arques, Hospital Son Dureta, Palma, Spain)] TJ ET
BT 26.250 88.310 Td /F1 9.8 Tf  [(Aranzaz� Gorospe, Hospital Son Dureta, Palma, Spain)] TJ ET
BT 26.250 68.905 Td /F1 9.8 Tf  [(In�s Legarda, Hospital Son Dureta, Palma, Spain)] TJ ET
BT 26.250 49.500 Td /F1 9.8 Tf  [(Mar�a Jos� Torres Rodr�guez, Hospital Son Dureta, Palma, Spain)] TJ ET
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BT 291.710 19.825 Td /F1 11.0 Tf  [(10)] TJ ET
BT 25.000 19.825 Td /F1 11.0 Tf  [(PLOS Currents Huntington Disease)] TJ ET

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BT 26.250 767.476 Td /F1 9.8 Tf  [(Barbara Vives, Hospital Son Dureta, Palma, Spain)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(F�tima Carrillo, Hospital Virgen del Roc�o, Sevilla, Spain)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Pablo Mir, Hospital Virgen del Roc�o, Sevilla, Spain)] TJ ET
BT 26.250 709.262 Td /F1 9.8 Tf  [(Mar�a Jos� Lama Suarez, Hospital Virgen del Roc�o, Sevilla, Spain)] TJ ET
BT 26.250 689.857 Td /F1 9.8 Tf  [(Ghada Loutfi, Norrlands Universitet Sjukhus, Department of Neurology, Ume�, Sweden)] TJ ET
BT 26.250 670.452 Td /F1 9.8 Tf  [(Eva-Lena Stattin, Norrlands Universitet Sjukhus, Department of Neurology, Ume�, Sweden)] TJ ET
BT 26.250 651.048 Td /F1 9.8 Tf  [(Laila Westman, Norrlands Universitet Sjukhus, Department of Neurology, Ume�, Sweden)] TJ ET
BT 26.250 631.643 Td /F1 9.8 Tf  [(Birgitta Wikstr�m, Norrlands Universitet Sjukhus, Department of Neurology, Ume�, Sweden)] TJ ET
BT 26.250 612.238 Td /F1 9.8 Tf  [(Sven P�lhagen, Karolinska-University Hospital, Stockholm, Sweden)] TJ ET
BT 26.250 592.833 Td /F1 9.8 Tf  [(Elisabeth Bj�rnsson, Karolinska-University Hospital, Stockholm, Sweden)] TJ ET
BT 26.250 573.429 Td /F1 9.8 Tf  [(Jean-Marc Burgunder, Neurologische Klinik des Inselspitals, Bern, Switzerland)] TJ ET
BT 26.250 554.024 Td /F1 9.8 Tf  [(Irene Romero, Zentrum f�r Bewegungsst�rungen, Neurologische Klinik und Poliklinik, Bern, Switzerland)] TJ ET
BT 26.250 534.619 Td /F1 9.8 Tf  [(Michael Sch�pbach, Zentrum f�r Bewegungsst�rungen, Neurologische Klinik und Poliklinik, Bern, Switzerland)] TJ ET
BT 26.250 515.214 Td /F1 9.8 Tf  [(Sabine Weber Zaugg, Zentrum f�r Bewegungsst�rungen, Neurologische Klinik und Poliklinik, Bern, Switzerland)] TJ ET
BT 26.250 495.810 Td /F1 9.8 Tf  [(Monique S.E. van Hout, Medisch Spectrum Twente, Ensched, The Netherlands)] TJ ET
BT 26.250 476.405 Td /F1 9.8 Tf  [(Jeroen P.P. van Vugt, Medisch Spectrum Twente, Ensched, The Netherlands)] TJ ET
BT 26.250 457.000 Td /F1 9.8 Tf  [(A. Marit de Weert, Medisch Spectrum Twente, Ensched, The Netherlands)] TJ ET
BT 26.250 437.595 Td /F1 9.8 Tf  [(J.J.W. Bolwijn, Polikliniek Neurologie, Groningen, The Netherlands)] TJ ET
BT 26.250 418.191 Td /F1 9.8 Tf  [(M. Dekker, Polikliniek Neurologie, Groningen, The Netherlands)] TJ ET
BT 26.250 398.786 Td /F1 9.8 Tf  [(K.L. Leenders, Polikliniek Neurologie, Groningen, The Netherlands)] TJ ET
BT 26.250 379.381 Td /F1 9.8 Tf  [(J.C.H. van Oostrom, Polikliniek Neurologie, Groningen, The Netherlands)] TJ ET
BT 26.250 359.976 Td /F1 9.8 Tf  [(Reineke Bos, Leiden University Medical Centre, Leiden, The Netherlands)] TJ ET
BT 26.250 340.572 Td /F1 9.8 Tf  [(Eve M. Dumas, Leiden University Medical Centre, Leiden, The Netherlands)] TJ ET
BT 26.250 321.167 Td /F1 9.8 Tf  [(Caroline K. Jurgens, Leiden University Medical Centre, Leiden, The Netherlands)] TJ ET
BT 26.250 301.762 Td /F1 9.8 Tf  [(Simon J. A. van den Bogaard, Leiden University Medical Centre, Leiden, The Netherlands)] TJ ET
BT 26.250 282.357 Td /F1 9.8 Tf  [(Raymund A.C. Roos, Leiden University Medical Centre, Leiden, The Netherlands)] TJ ET
BT 26.250 262.953 Td /F1 9.8 Tf  [(Marie-No�lle Witjes-An�, Leiden University Medical Centre, Leiden, The Netherlands)] TJ ET
BT 26.250 243.548 Td /F1 9.8 Tf  [(Berry Kremer, Universitair Medisch Centrum St. Radboud, Neurology, Nijmegen, The Netherlands)] TJ ET
BT 26.250 224.143 Td /F1 9.8 Tf  [(C.C.P. Verstappen, Universitair Medisch Centrum St. Radboud, Neurology, Nijmegen, The Netherlands)] TJ ET
BT 26.250 204.738 Td /F1 9.8 Tf  [(Jenny de Souza, The Barberry Centre, Dept of Psychiatry, Birmingham, UK)] TJ ET
BT 26.250 185.334 Td /F1 9.8 Tf  [(Hugh Rickards, The Barberry Centre, Dept of Psychiatry, Birmingham, UK)] TJ ET
BT 26.250 165.929 Td /F1 9.8 Tf  [(Jan Wright, The Barberry Centre, Dept of Psychiatry, Birmingham, UK)] TJ ET
BT 26.250 146.524 Td /F1 9.8 Tf  [(Roger A. Barker, Cambridge Centre for Brain Repair, Forvie Site, Cambridge, UK)] TJ ET
BT 26.250 127.119 Td /F1 9.8 Tf  [(Kate Fisher, Cambridge Centre for Brain Repair, Forvie Site, Cambridge, UK)] TJ ET
BT 26.250 107.715 Td /F1 9.8 Tf  [(Anna Olivia Goyder Goodman, Cambridge Centre for Brain Repair, Forvie Site, Cambridge, UK)] TJ ET
BT 26.250 88.310 Td /F1 9.8 Tf  [(Susan Hill, Cambridge Centre for Brain Repair, Forvie Site, Cambridge, UK)] TJ ET
BT 26.250 68.905 Td /F1 9.8 Tf  [(Ann Kershaw, Cambridge Centre for Brain Repair, Forvie Site, Cambridge, UK)] TJ ET
BT 26.250 49.500 Td /F1 9.8 Tf  [(Sarah Mason, Cambridge Centre for Brain Repair, Forvie Site, Cambridge, UK)] TJ ET
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BT 26.250 767.476 Td /F1 9.8 Tf  [(Barbara Vives, Hospital Son Dureta, Palma, Spain)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(F�tima Carrillo, Hospital Virgen del Roc�o, Sevilla, Spain)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Pablo Mir, Hospital Virgen del Roc�o, Sevilla, Spain)] TJ ET
BT 26.250 709.262 Td /F1 9.8 Tf  [(Mar�a Jos� Lama Suarez, Hospital Virgen del Roc�o, Sevilla, Spain)] TJ ET
BT 26.250 689.857 Td /F1 9.8 Tf  [(Ghada Loutfi, Norrlands Universitet Sjukhus, Department of Neurology, Ume�, Sweden)] TJ ET
BT 26.250 670.452 Td /F1 9.8 Tf  [(Eva-Lena Stattin, Norrlands Universitet Sjukhus, Department of Neurology, Ume�, Sweden)] TJ ET
BT 26.250 651.048 Td /F1 9.8 Tf  [(Laila Westman, Norrlands Universitet Sjukhus, Department of Neurology, Ume�, Sweden)] TJ ET
BT 26.250 631.643 Td /F1 9.8 Tf  [(Birgitta Wikstr�m, Norrlands Universitet Sjukhus, Department of Neurology, Ume�, Sweden)] TJ ET
BT 26.250 612.238 Td /F1 9.8 Tf  [(Sven P�lhagen, Karolinska-University Hospital, Stockholm, Sweden)] TJ ET
BT 26.250 592.833 Td /F1 9.8 Tf  [(Elisabeth Bj�rnsson, Karolinska-University Hospital, Stockholm, Sweden)] TJ ET
BT 26.250 573.429 Td /F1 9.8 Tf  [(Jean-Marc Burgunder, Neurologische Klinik des Inselspitals, Bern, Switzerland)] TJ ET
BT 26.250 554.024 Td /F1 9.8 Tf  [(Irene Romero, Zentrum f�r Bewegungsst�rungen, Neurologische Klinik und Poliklinik, Bern, Switzerland)] TJ ET
BT 26.250 534.619 Td /F1 9.8 Tf  [(Michael Sch�pbach, Zentrum f�r Bewegungsst�rungen, Neurologische Klinik und Poliklinik, Bern, Switzerland)] TJ ET
BT 26.250 515.214 Td /F1 9.8 Tf  [(Sabine Weber Zaugg, Zentrum f�r Bewegungsst�rungen, Neurologische Klinik und Poliklinik, Bern, Switzerland)] TJ ET
BT 26.250 495.810 Td /F1 9.8 Tf  [(Monique S.E. van Hout, Medisch Spectrum Twente, Ensched, The Netherlands)] TJ ET
BT 26.250 476.405 Td /F1 9.8 Tf  [(Jeroen P.P. van Vugt, Medisch Spectrum Twente, Ensched, The Netherlands)] TJ ET
BT 26.250 457.000 Td /F1 9.8 Tf  [(A. Marit de Weert, Medisch Spectrum Twente, Ensched, The Netherlands)] TJ ET
BT 26.250 437.595 Td /F1 9.8 Tf  [(J.J.W. Bolwijn, Polikliniek Neurologie, Groningen, The Netherlands)] TJ ET
BT 26.250 418.191 Td /F1 9.8 Tf  [(M. Dekker, Polikliniek Neurologie, Groningen, The Netherlands)] TJ ET
BT 26.250 398.786 Td /F1 9.8 Tf  [(K.L. Leenders, Polikliniek Neurologie, Groningen, The Netherlands)] TJ ET
BT 26.250 379.381 Td /F1 9.8 Tf  [(J.C.H. van Oostrom, Polikliniek Neurologie, Groningen, The Netherlands)] TJ ET
BT 26.250 359.976 Td /F1 9.8 Tf  [(Reineke Bos, Leiden University Medical Centre, Leiden, The Netherlands)] TJ ET
BT 26.250 340.572 Td /F1 9.8 Tf  [(Eve M. Dumas, Leiden University Medical Centre, Leiden, The Netherlands)] TJ ET
BT 26.250 321.167 Td /F1 9.8 Tf  [(Caroline K. Jurgens, Leiden University Medical Centre, Leiden, The Netherlands)] TJ ET
BT 26.250 301.762 Td /F1 9.8 Tf  [(Simon J. A. van den Bogaard, Leiden University Medical Centre, Leiden, The Netherlands)] TJ ET
BT 26.250 282.357 Td /F1 9.8 Tf  [(Raymund A.C. Roos, Leiden University Medical Centre, Leiden, The Netherlands)] TJ ET
BT 26.250 262.953 Td /F1 9.8 Tf  [(Marie-No�lle Witjes-An�, Leiden University Medical Centre, Leiden, The Netherlands)] TJ ET
BT 26.250 243.548 Td /F1 9.8 Tf  [(Berry Kremer, Universitair Medisch Centrum St. Radboud, Neurology, Nijmegen, The Netherlands)] TJ ET
BT 26.250 224.143 Td /F1 9.8 Tf  [(C.C.P. Verstappen, Universitair Medisch Centrum St. Radboud, Neurology, Nijmegen, The Netherlands)] TJ ET
BT 26.250 204.738 Td /F1 9.8 Tf  [(Jenny de Souza, The Barberry Centre, Dept of Psychiatry, Birmingham, UK)] TJ ET
BT 26.250 185.334 Td /F1 9.8 Tf  [(Hugh Rickards, The Barberry Centre, Dept of Psychiatry, Birmingham, UK)] TJ ET
BT 26.250 165.929 Td /F1 9.8 Tf  [(Jan Wright, The Barberry Centre, Dept of Psychiatry, Birmingham, UK)] TJ ET
BT 26.250 146.524 Td /F1 9.8 Tf  [(Roger A. Barker, Cambridge Centre for Brain Repair, Forvie Site, Cambridge, UK)] TJ ET
BT 26.250 127.119 Td /F1 9.8 Tf  [(Kate Fisher, Cambridge Centre for Brain Repair, Forvie Site, Cambridge, UK)] TJ ET
BT 26.250 107.715 Td /F1 9.8 Tf  [(Anna Olivia Goyder Goodman, Cambridge Centre for Brain Repair, Forvie Site, Cambridge, UK)] TJ ET
BT 26.250 88.310 Td /F1 9.8 Tf  [(Susan Hill, Cambridge Centre for Brain Repair, Forvie Site, Cambridge, UK)] TJ ET
BT 26.250 68.905 Td /F1 9.8 Tf  [(Ann Kershaw, Cambridge Centre for Brain Repair, Forvie Site, Cambridge, UK)] TJ ET
BT 26.250 49.500 Td /F1 9.8 Tf  [(Sarah Mason, Cambridge Centre for Brain Repair, Forvie Site, Cambridge, UK)] TJ ET
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BT 26.250 767.476 Td /F1 9.8 Tf  [(Barbara Vives, Hospital Son Dureta, Palma, Spain)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(F�tima Carrillo, Hospital Virgen del Roc�o, Sevilla, Spain)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Pablo Mir, Hospital Virgen del Roc�o, Sevilla, Spain)] TJ ET
BT 26.250 709.262 Td /F1 9.8 Tf  [(Mar�a Jos� Lama Suarez, Hospital Virgen del Roc�o, Sevilla, Spain)] TJ ET
BT 26.250 689.857 Td /F1 9.8 Tf  [(Ghada Loutfi, Norrlands Universitet Sjukhus, Department of Neurology, Ume�, Sweden)] TJ ET
BT 26.250 670.452 Td /F1 9.8 Tf  [(Eva-Lena Stattin, Norrlands Universitet Sjukhus, Department of Neurology, Ume�, Sweden)] TJ ET
BT 26.250 651.048 Td /F1 9.8 Tf  [(Laila Westman, Norrlands Universitet Sjukhus, Department of Neurology, Ume�, Sweden)] TJ ET
BT 26.250 631.643 Td /F1 9.8 Tf  [(Birgitta Wikstr�m, Norrlands Universitet Sjukhus, Department of Neurology, Ume�, Sweden)] TJ ET
BT 26.250 612.238 Td /F1 9.8 Tf  [(Sven P�lhagen, Karolinska-University Hospital, Stockholm, Sweden)] TJ ET
BT 26.250 592.833 Td /F1 9.8 Tf  [(Elisabeth Bj�rnsson, Karolinska-University Hospital, Stockholm, Sweden)] TJ ET
BT 26.250 573.429 Td /F1 9.8 Tf  [(Jean-Marc Burgunder, Neurologische Klinik des Inselspitals, Bern, Switzerland)] TJ ET
BT 26.250 554.024 Td /F1 9.8 Tf  [(Irene Romero, Zentrum f�r Bewegungsst�rungen, Neurologische Klinik und Poliklinik, Bern, Switzerland)] TJ ET
BT 26.250 534.619 Td /F1 9.8 Tf  [(Michael Sch�pbach, Zentrum f�r Bewegungsst�rungen, Neurologische Klinik und Poliklinik, Bern, Switzerland)] TJ ET
BT 26.250 515.214 Td /F1 9.8 Tf  [(Sabine Weber Zaugg, Zentrum f�r Bewegungsst�rungen, Neurologische Klinik und Poliklinik, Bern, Switzerland)] TJ ET
BT 26.250 495.810 Td /F1 9.8 Tf  [(Monique S.E. van Hout, Medisch Spectrum Twente, Ensched, The Netherlands)] TJ ET
BT 26.250 476.405 Td /F1 9.8 Tf  [(Jeroen P.P. van Vugt, Medisch Spectrum Twente, Ensched, The Netherlands)] TJ ET
BT 26.250 457.000 Td /F1 9.8 Tf  [(A. Marit de Weert, Medisch Spectrum Twente, Ensched, The Netherlands)] TJ ET
BT 26.250 437.595 Td /F1 9.8 Tf  [(J.J.W. Bolwijn, Polikliniek Neurologie, Groningen, The Netherlands)] TJ ET
BT 26.250 418.191 Td /F1 9.8 Tf  [(M. Dekker, Polikliniek Neurologie, Groningen, The Netherlands)] TJ ET
BT 26.250 398.786 Td /F1 9.8 Tf  [(K.L. Leenders, Polikliniek Neurologie, Groningen, The Netherlands)] TJ ET
BT 26.250 379.381 Td /F1 9.8 Tf  [(J.C.H. van Oostrom, Polikliniek Neurologie, Groningen, The Netherlands)] TJ ET
BT 26.250 359.976 Td /F1 9.8 Tf  [(Reineke Bos, Leiden University Medical Centre, Leiden, The Netherlands)] TJ ET
BT 26.250 340.572 Td /F1 9.8 Tf  [(Eve M. Dumas, Leiden University Medical Centre, Leiden, The Netherlands)] TJ ET
BT 26.250 321.167 Td /F1 9.8 Tf  [(Caroline K. Jurgens, Leiden University Medical Centre, Leiden, The Netherlands)] TJ ET
BT 26.250 301.762 Td /F1 9.8 Tf  [(Simon J. A. van den Bogaard, Leiden University Medical Centre, Leiden, The Netherlands)] TJ ET
BT 26.250 282.357 Td /F1 9.8 Tf  [(Raymund A.C. Roos, Leiden University Medical Centre, Leiden, The Netherlands)] TJ ET
BT 26.250 262.953 Td /F1 9.8 Tf  [(Marie-No�lle Witjes-An�, Leiden University Medical Centre, Leiden, The Netherlands)] TJ ET
BT 26.250 243.548 Td /F1 9.8 Tf  [(Berry Kremer, Universitair Medisch Centrum St. Radboud, Neurology, Nijmegen, The Netherlands)] TJ ET
BT 26.250 224.143 Td /F1 9.8 Tf  [(C.C.P. Verstappen, Universitair Medisch Centrum St. Radboud, Neurology, Nijmegen, The Netherlands)] TJ ET
BT 26.250 204.738 Td /F1 9.8 Tf  [(Jenny de Souza, The Barberry Centre, Dept of Psychiatry, Birmingham, UK)] TJ ET
BT 26.250 185.334 Td /F1 9.8 Tf  [(Hugh Rickards, The Barberry Centre, Dept of Psychiatry, Birmingham, UK)] TJ ET
BT 26.250 165.929 Td /F1 9.8 Tf  [(Jan Wright, The Barberry Centre, Dept of Psychiatry, Birmingham, UK)] TJ ET
BT 26.250 146.524 Td /F1 9.8 Tf  [(Roger A. Barker, Cambridge Centre for Brain Repair, Forvie Site, Cambridge, UK)] TJ ET
BT 26.250 127.119 Td /F1 9.8 Tf  [(Kate Fisher, Cambridge Centre for Brain Repair, Forvie Site, Cambridge, UK)] TJ ET
BT 26.250 107.715 Td /F1 9.8 Tf  [(Anna Olivia Goyder Goodman, Cambridge Centre for Brain Repair, Forvie Site, Cambridge, UK)] TJ ET
BT 26.250 88.310 Td /F1 9.8 Tf  [(Susan Hill, Cambridge Centre for Brain Repair, Forvie Site, Cambridge, UK)] TJ ET
BT 26.250 68.905 Td /F1 9.8 Tf  [(Ann Kershaw, Cambridge Centre for Brain Repair, Forvie Site, Cambridge, UK)] TJ ET
BT 26.250 49.500 Td /F1 9.8 Tf  [(Sarah Mason, Cambridge Centre for Brain Repair, Forvie Site, Cambridge, UK)] TJ ET
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BT 291.710 19.825 Td /F1 11.0 Tf  [(11)] TJ ET
BT 25.000 19.825 Td /F1 11.0 Tf  [(PLOS Currents Huntington Disease)] TJ ET

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BT 26.250 767.476 Td /F1 9.8 Tf  [(Nicole Paterson, Cambridge Centre for Brain Repair, Forvie Site, Cambridge, UK)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(Lucy Raymond, Cambridge Centre for Brain Repair, Forvie Site, Cambridge, UK)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Johnathan Bisson, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 709.262 Td /F1 9.8 Tf  [(Monica Busse, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 689.857 Td /F1 9.8 Tf  [(Lynda Ellison-Rose, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 670.452 Td /F1 9.8 Tf  [(Olivia Handley, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 651.048 Td /F1 9.8 Tf  [(Sarah Hunt, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 631.643 Td /F1 9.8 Tf  [(Jenny Naji, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 612.238 Td /F1 9.8 Tf  [(Kathleen Price, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 592.833 Td /F1 9.8 Tf  [(Anne Rosser, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 573.429 Td /F1 9.8 Tf  [(Stephen Dunnett, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 554.024 Td /F1 9.8 Tf  [(Maureen Edwards, Molecular Medicine Centre, Western General Hospital, Department of Clinical Genetics, Edinburgh, UK)] TJ ET
BT 26.250 534.619 Td /F1 9.8 Tf  [(Paul A. De Sousa, Molecular Medicine Centre, Western General Hospital, Department of Clinical Genetics, Edinburgh, UK)] TJ ET
BT 26.250 515.214 Td /F1 9.8 Tf  [(Teresa Hughes \(Scottish Huntington�s Association\), Molecular Medicine Centre, Western General Hospital, Department of )] TJ ET
BT 26.250 503.310 Td /F1 9.8 Tf  [(Clinical Genetics, Edinburgh, UK)] TJ ET
BT 26.250 483.905 Td /F1 9.8 Tf  [(Marie McGill, Molecular Medicine Centre, Western General Hospital, Department of Clinical Genetics, Edinburgh, UK)] TJ ET
BT 26.250 464.500 Td /F1 9.8 Tf  [(Pauline Pearson, Molecular Medicine Centre, Western General Hospital, Department of Clinical Genetics, Edinburgh, UK)] TJ ET
BT 26.250 445.095 Td /F1 9.8 Tf  [(Mary Porteous, Molecular Medicine Centre, Western General Hospital, Department of Clinical Genetics, Edinburgh, UK)] TJ ET
BT 26.250 425.691 Td /F1 9.8 Tf  [(Paul Smith \(Scottish Huntington�s Association\), Molecular Medicine Centre, Western General Hospital, Department of Clinical )] TJ ET
BT 26.250 413.786 Td /F1 9.8 Tf  [(Genetics, Edinburgh, UK)] TJ ET
BT 26.250 394.381 Td /F1 9.8 Tf  [(Adam Zeman, Molecular Medicine Centre, Western General Hospital, Department of Clinical Genetics, Edinburgh, UK)] TJ ET
BT 26.250 374.976 Td /F1 9.8 Tf  [(Nicol Lambord, Heavitree Hospital, Exeter , UK)] TJ ET
BT 26.250 355.572 Td /F1 9.8 Tf  [(Julia Rankin, Heavitree Hospital, Exeter , UK)] TJ ET
BT 26.250 336.167 Td /F1 9.8 Tf  [(Liz Burrows, Department of Neurology Gloucestershire Royal Hospital, Gloucester, UK)] TJ ET
BT 26.250 316.762 Td /F1 9.8 Tf  [(Amy Fletcher, Department of Neurology Gloucestershire Royal Hospital, Gloucester, UK)] TJ ET
BT 26.250 297.357 Td /F1 9.8 Tf  [(Fiona Laver, Department of Neurology Gloucestershire Royal Hospital, Gloucester, UK)] TJ ET
BT 26.250 277.953 Td /F1 9.8 Tf  [(Mark Silva, Department of Neurology Gloucestershire Royal Hospital, Gloucester, UK)] TJ ET
BT 26.250 258.548 Td /F1 9.8 Tf  [(Aileen Thomson, Department of Neurology Gloucestershire Royal Hospital, Gloucester, UK)] TJ ET
BT 26.250 239.143 Td /F1 9.8 Tf  [(Thomasin Andrews, Guy�s Hospital, London , UK)] TJ ET
BT 26.250 219.738 Td /F1 9.8 Tf  [(Andrew Dougherty, Guy�s Hospital, London , UK)] TJ ET
BT 26.250 200.334 Td /F1 9.8 Tf  [(Fred Kavalier, Guy�s Hospital, London , UK)] TJ ET
BT 26.250 180.929 Td /F1 9.8 Tf  [(Charlotte Golding, Guy�s Hospital, London , UK)] TJ ET
BT 26.250 161.524 Td /F1 9.8 Tf  [(Alison Lashwood, Guy�s Hospital, London , UK)] TJ ET
BT 26.250 142.119 Td /F1 9.8 Tf  [(Dene Robertson, Guy�s Hospital, London , UK)] TJ ET
BT 26.250 122.715 Td /F1 9.8 Tf  [(Deborah Ruddy, Guy�s Hospital, London , UK)] TJ ET
BT 26.250 103.310 Td /F1 9.8 Tf  [(Anna Whaite, Guy�s Hospital, London , UK)] TJ ET
BT 26.250 83.905 Td /F1 9.8 Tf  [(Michael Patton, St. Georges-Hospital, London, UK)] TJ ET
BT 26.250 64.500 Td /F1 9.8 Tf  [(Maria Patterson, St. Georges-Hospital, London, UK)] TJ ET
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q
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0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(Nicole Paterson, Cambridge Centre for Brain Repair, Forvie Site, Cambridge, UK)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(Lucy Raymond, Cambridge Centre for Brain Repair, Forvie Site, Cambridge, UK)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Johnathan Bisson, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 709.262 Td /F1 9.8 Tf  [(Monica Busse, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 689.857 Td /F1 9.8 Tf  [(Lynda Ellison-Rose, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 670.452 Td /F1 9.8 Tf  [(Olivia Handley, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 651.048 Td /F1 9.8 Tf  [(Sarah Hunt, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 631.643 Td /F1 9.8 Tf  [(Jenny Naji, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 612.238 Td /F1 9.8 Tf  [(Kathleen Price, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 592.833 Td /F1 9.8 Tf  [(Anne Rosser, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 573.429 Td /F1 9.8 Tf  [(Stephen Dunnett, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 554.024 Td /F1 9.8 Tf  [(Maureen Edwards, Molecular Medicine Centre, Western General Hospital, Department of Clinical Genetics, Edinburgh, UK)] TJ ET
BT 26.250 534.619 Td /F1 9.8 Tf  [(Paul A. De Sousa, Molecular Medicine Centre, Western General Hospital, Department of Clinical Genetics, Edinburgh, UK)] TJ ET
BT 26.250 515.214 Td /F1 9.8 Tf  [(Teresa Hughes \(Scottish Huntington�s Association\), Molecular Medicine Centre, Western General Hospital, Department of )] TJ ET
BT 26.250 503.310 Td /F1 9.8 Tf  [(Clinical Genetics, Edinburgh, UK)] TJ ET
BT 26.250 483.905 Td /F1 9.8 Tf  [(Marie McGill, Molecular Medicine Centre, Western General Hospital, Department of Clinical Genetics, Edinburgh, UK)] TJ ET
BT 26.250 464.500 Td /F1 9.8 Tf  [(Pauline Pearson, Molecular Medicine Centre, Western General Hospital, Department of Clinical Genetics, Edinburgh, UK)] TJ ET
BT 26.250 445.095 Td /F1 9.8 Tf  [(Mary Porteous, Molecular Medicine Centre, Western General Hospital, Department of Clinical Genetics, Edinburgh, UK)] TJ ET
BT 26.250 425.691 Td /F1 9.8 Tf  [(Paul Smith \(Scottish Huntington�s Association\), Molecular Medicine Centre, Western General Hospital, Department of Clinical )] TJ ET
BT 26.250 413.786 Td /F1 9.8 Tf  [(Genetics, Edinburgh, UK)] TJ ET
BT 26.250 394.381 Td /F1 9.8 Tf  [(Adam Zeman, Molecular Medicine Centre, Western General Hospital, Department of Clinical Genetics, Edinburgh, UK)] TJ ET
BT 26.250 374.976 Td /F1 9.8 Tf  [(Nicol Lambord, Heavitree Hospital, Exeter , UK)] TJ ET
BT 26.250 355.572 Td /F1 9.8 Tf  [(Julia Rankin, Heavitree Hospital, Exeter , UK)] TJ ET
BT 26.250 336.167 Td /F1 9.8 Tf  [(Liz Burrows, Department of Neurology Gloucestershire Royal Hospital, Gloucester, UK)] TJ ET
BT 26.250 316.762 Td /F1 9.8 Tf  [(Amy Fletcher, Department of Neurology Gloucestershire Royal Hospital, Gloucester, UK)] TJ ET
BT 26.250 297.357 Td /F1 9.8 Tf  [(Fiona Laver, Department of Neurology Gloucestershire Royal Hospital, Gloucester, UK)] TJ ET
BT 26.250 277.953 Td /F1 9.8 Tf  [(Mark Silva, Department of Neurology Gloucestershire Royal Hospital, Gloucester, UK)] TJ ET
BT 26.250 258.548 Td /F1 9.8 Tf  [(Aileen Thomson, Department of Neurology Gloucestershire Royal Hospital, Gloucester, UK)] TJ ET
BT 26.250 239.143 Td /F1 9.8 Tf  [(Thomasin Andrews, Guy�s Hospital, London , UK)] TJ ET
BT 26.250 219.738 Td /F1 9.8 Tf  [(Andrew Dougherty, Guy�s Hospital, London , UK)] TJ ET
BT 26.250 200.334 Td /F1 9.8 Tf  [(Fred Kavalier, Guy�s Hospital, London , UK)] TJ ET
BT 26.250 180.929 Td /F1 9.8 Tf  [(Charlotte Golding, Guy�s Hospital, London , UK)] TJ ET
BT 26.250 161.524 Td /F1 9.8 Tf  [(Alison Lashwood, Guy�s Hospital, London , UK)] TJ ET
BT 26.250 142.119 Td /F1 9.8 Tf  [(Dene Robertson, Guy�s Hospital, London , UK)] TJ ET
BT 26.250 122.715 Td /F1 9.8 Tf  [(Deborah Ruddy, Guy�s Hospital, London , UK)] TJ ET
BT 26.250 103.310 Td /F1 9.8 Tf  [(Anna Whaite, Guy�s Hospital, London , UK)] TJ ET
BT 26.250 83.905 Td /F1 9.8 Tf  [(Michael Patton, St. Georges-Hospital, London, UK)] TJ ET
BT 26.250 64.500 Td /F1 9.8 Tf  [(Maria Patterson, St. Georges-Hospital, London, UK)] TJ ET
Q
q
15.000 35.215 577.500 741.785 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(Nicole Paterson, Cambridge Centre for Brain Repair, Forvie Site, Cambridge, UK)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(Lucy Raymond, Cambridge Centre for Brain Repair, Forvie Site, Cambridge, UK)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Johnathan Bisson, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 709.262 Td /F1 9.8 Tf  [(Monica Busse, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 689.857 Td /F1 9.8 Tf  [(Lynda Ellison-Rose, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 670.452 Td /F1 9.8 Tf  [(Olivia Handley, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 651.048 Td /F1 9.8 Tf  [(Sarah Hunt, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 631.643 Td /F1 9.8 Tf  [(Jenny Naji, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 612.238 Td /F1 9.8 Tf  [(Kathleen Price, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 592.833 Td /F1 9.8 Tf  [(Anne Rosser, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 573.429 Td /F1 9.8 Tf  [(Stephen Dunnett, The Institute of Medical Genetics, University Hospital of Wales, Cardiff, UK)] TJ ET
BT 26.250 554.024 Td /F1 9.8 Tf  [(Maureen Edwards, Molecular Medicine Centre, Western General Hospital, Department of Clinical Genetics, Edinburgh, UK)] TJ ET
BT 26.250 534.619 Td /F1 9.8 Tf  [(Paul A. De Sousa, Molecular Medicine Centre, Western General Hospital, Department of Clinical Genetics, Edinburgh, UK)] TJ ET
BT 26.250 515.214 Td /F1 9.8 Tf  [(Teresa Hughes \(Scottish Huntington�s Association\), Molecular Medicine Centre, Western General Hospital, Department of )] TJ ET
BT 26.250 503.310 Td /F1 9.8 Tf  [(Clinical Genetics, Edinburgh, UK)] TJ ET
BT 26.250 483.905 Td /F1 9.8 Tf  [(Marie McGill, Molecular Medicine Centre, Western General Hospital, Department of Clinical Genetics, Edinburgh, UK)] TJ ET
BT 26.250 464.500 Td /F1 9.8 Tf  [(Pauline Pearson, Molecular Medicine Centre, Western General Hospital, Department of Clinical Genetics, Edinburgh, UK)] TJ ET
BT 26.250 445.095 Td /F1 9.8 Tf  [(Mary Porteous, Molecular Medicine Centre, Western General Hospital, Department of Clinical Genetics, Edinburgh, UK)] TJ ET
BT 26.250 425.691 Td /F1 9.8 Tf  [(Paul Smith \(Scottish Huntington�s Association\), Molecular Medicine Centre, Western General Hospital, Department of Clinical )] TJ ET
BT 26.250 413.786 Td /F1 9.8 Tf  [(Genetics, Edinburgh, UK)] TJ ET
BT 26.250 394.381 Td /F1 9.8 Tf  [(Adam Zeman, Molecular Medicine Centre, Western General Hospital, Department of Clinical Genetics, Edinburgh, UK)] TJ ET
BT 26.250 374.976 Td /F1 9.8 Tf  [(Nicol Lambord, Heavitree Hospital, Exeter , UK)] TJ ET
BT 26.250 355.572 Td /F1 9.8 Tf  [(Julia Rankin, Heavitree Hospital, Exeter , UK)] TJ ET
BT 26.250 336.167 Td /F1 9.8 Tf  [(Liz Burrows, Department of Neurology Gloucestershire Royal Hospital, Gloucester, UK)] TJ ET
BT 26.250 316.762 Td /F1 9.8 Tf  [(Amy Fletcher, Department of Neurology Gloucestershire Royal Hospital, Gloucester, UK)] TJ ET
BT 26.250 297.357 Td /F1 9.8 Tf  [(Fiona Laver, Department of Neurology Gloucestershire Royal Hospital, Gloucester, UK)] TJ ET
BT 26.250 277.953 Td /F1 9.8 Tf  [(Mark Silva, Department of Neurology Gloucestershire Royal Hospital, Gloucester, UK)] TJ ET
BT 26.250 258.548 Td /F1 9.8 Tf  [(Aileen Thomson, Department of Neurology Gloucestershire Royal Hospital, Gloucester, UK)] TJ ET
BT 26.250 239.143 Td /F1 9.8 Tf  [(Thomasin Andrews, Guy�s Hospital, London , UK)] TJ ET
BT 26.250 219.738 Td /F1 9.8 Tf  [(Andrew Dougherty, Guy�s Hospital, London , UK)] TJ ET
BT 26.250 200.334 Td /F1 9.8 Tf  [(Fred Kavalier, Guy�s Hospital, London , UK)] TJ ET
BT 26.250 180.929 Td /F1 9.8 Tf  [(Charlotte Golding, Guy�s Hospital, London , UK)] TJ ET
BT 26.250 161.524 Td /F1 9.8 Tf  [(Alison Lashwood, Guy�s Hospital, London , UK)] TJ ET
BT 26.250 142.119 Td /F1 9.8 Tf  [(Dene Robertson, Guy�s Hospital, London , UK)] TJ ET
BT 26.250 122.715 Td /F1 9.8 Tf  [(Deborah Ruddy, Guy�s Hospital, London , UK)] TJ ET
BT 26.250 103.310 Td /F1 9.8 Tf  [(Anna Whaite, Guy�s Hospital, London , UK)] TJ ET
BT 26.250 83.905 Td /F1 9.8 Tf  [(Michael Patton, St. Georges-Hospital, London, UK)] TJ ET
BT 26.250 64.500 Td /F1 9.8 Tf  [(Maria Patterson, St. Georges-Hospital, London, UK)] TJ ET
Q
q
0.000 0.000 0.000 rg
BT 291.710 19.825 Td /F1 11.0 Tf  [(12)] TJ ET
BT 25.000 19.825 Td /F1 11.0 Tf  [(PLOS Currents Huntington Disease)] TJ ET

Q
endstream
endobj
163 0 obj
<< /Type /Page
/Parent 3 0 R
/Contents 164 0 R
>>
endobj
164 0 obj
<<
/Length 16604 >>
stream

0.271 0.267 0.267 rg
q
15.000 32.596 577.500 744.404 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(Colin Bourne, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(Carole Clayton, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Heather Dipple, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 709.262 Td /F1 9.8 Tf  [(Jackie Clapton, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 689.857 Td /F1 9.8 Tf  [(Janet Grant, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 670.452 Td /F1 9.8 Tf  [(Diana Gross, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 651.048 Td /F1 9.8 Tf  [(Caroline Hallam, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 631.643 Td /F1 9.8 Tf  [(Julia Middleton, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 612.238 Td /F1 9.8 Tf  [(Ann Murch, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 592.833 Td /F1 9.8 Tf  [(Dawn Patino, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 573.429 Td /F1 9.8 Tf  [(Thomasin Andrews, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 554.024 Td /F1 9.8 Tf  [(Stefania Bruno, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 534.619 Td /F1 9.8 Tf  [(Elvina Chu, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 515.214 Td /F1 9.8 Tf  [(Karen Doherty, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 495.810 Td /F1 9.8 Tf  [(Nayana Lahiri, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 476.405 Td /F1 9.8 Tf  [(Marianne Novak, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 457.000 Td /F1 9.8 Tf  [(Aakta Patel, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 437.595 Td /F1 9.8 Tf  [(Sarah Tabrizi, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 418.191 Td /F1 9.8 Tf  [(Rachel Taylor, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 398.786 Td /F1 9.8 Tf  [(Thomas Warner, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 379.381 Td /F1 9.8 Tf  [(Edward Wild, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 359.976 Td /F1 9.8 Tf  [(Natalie Arran, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 348.072 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 328.667 Td /F1 9.8 Tf  [(David Craufurd, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 316.762 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 297.357 Td /F1 9.8 Tf  [(Ruth Fullam, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 285.453 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 266.048 Td /F1 9.8 Tf  [(Liz Howard, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 254.143 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 234.738 Td /F1 9.8 Tf  [(Susan Huson, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 222.834 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 203.429 Td /F1 9.8 Tf  [(Lucy Partington-Jones, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 191.524 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 172.119 Td /F1 9.8 Tf  [(Nichola Verstraelen \(formerly Ritchie\), Genetic Medicine, University of Manchester, Manchester Academic Health Sciences )] TJ ET
BT 26.250 160.215 Td /F1 9.8 Tf  [(Centre and Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 140.810 Td /F1 9.8 Tf  [(Julie Snowden, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 128.905 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 109.500 Td /F1 9.8 Tf  [(Andrea Sollom, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 97.596 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 78.191 Td /F1 9.8 Tf  [(Cheryl Stopford, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 66.286 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 46.881 Td /F1 9.8 Tf  [(Jennifer Thompson, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
Q
q
15.000 32.596 577.500 744.404 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(Colin Bourne, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(Carole Clayton, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Heather Dipple, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 709.262 Td /F1 9.8 Tf  [(Jackie Clapton, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 689.857 Td /F1 9.8 Tf  [(Janet Grant, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 670.452 Td /F1 9.8 Tf  [(Diana Gross, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 651.048 Td /F1 9.8 Tf  [(Caroline Hallam, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 631.643 Td /F1 9.8 Tf  [(Julia Middleton, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 612.238 Td /F1 9.8 Tf  [(Ann Murch, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 592.833 Td /F1 9.8 Tf  [(Dawn Patino, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 573.429 Td /F1 9.8 Tf  [(Thomasin Andrews, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 554.024 Td /F1 9.8 Tf  [(Stefania Bruno, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 534.619 Td /F1 9.8 Tf  [(Elvina Chu, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 515.214 Td /F1 9.8 Tf  [(Karen Doherty, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 495.810 Td /F1 9.8 Tf  [(Nayana Lahiri, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 476.405 Td /F1 9.8 Tf  [(Marianne Novak, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 457.000 Td /F1 9.8 Tf  [(Aakta Patel, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 437.595 Td /F1 9.8 Tf  [(Sarah Tabrizi, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 418.191 Td /F1 9.8 Tf  [(Rachel Taylor, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 398.786 Td /F1 9.8 Tf  [(Thomas Warner, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 379.381 Td /F1 9.8 Tf  [(Edward Wild, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 359.976 Td /F1 9.8 Tf  [(Natalie Arran, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 348.072 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 328.667 Td /F1 9.8 Tf  [(David Craufurd, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 316.762 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 297.357 Td /F1 9.8 Tf  [(Ruth Fullam, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 285.453 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 266.048 Td /F1 9.8 Tf  [(Liz Howard, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 254.143 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 234.738 Td /F1 9.8 Tf  [(Susan Huson, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 222.834 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 203.429 Td /F1 9.8 Tf  [(Lucy Partington-Jones, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 191.524 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 172.119 Td /F1 9.8 Tf  [(Nichola Verstraelen \(formerly Ritchie\), Genetic Medicine, University of Manchester, Manchester Academic Health Sciences )] TJ ET
BT 26.250 160.215 Td /F1 9.8 Tf  [(Centre and Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 140.810 Td /F1 9.8 Tf  [(Julie Snowden, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 128.905 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 109.500 Td /F1 9.8 Tf  [(Andrea Sollom, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 97.596 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 78.191 Td /F1 9.8 Tf  [(Cheryl Stopford, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 66.286 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 46.881 Td /F1 9.8 Tf  [(Jennifer Thompson, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
Q
q
15.000 32.596 577.500 744.404 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(Colin Bourne, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(Carole Clayton, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 728.667 Td /F1 9.8 Tf  [(Heather Dipple, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 709.262 Td /F1 9.8 Tf  [(Jackie Clapton, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 689.857 Td /F1 9.8 Tf  [(Janet Grant, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 670.452 Td /F1 9.8 Tf  [(Diana Gross, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 651.048 Td /F1 9.8 Tf  [(Caroline Hallam, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 631.643 Td /F1 9.8 Tf  [(Julia Middleton, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 612.238 Td /F1 9.8 Tf  [(Ann Murch, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 592.833 Td /F1 9.8 Tf  [(Dawn Patino, Leicestershire Partnership Trust, Mill Lodge, Leicester, UK)] TJ ET
BT 26.250 573.429 Td /F1 9.8 Tf  [(Thomasin Andrews, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 554.024 Td /F1 9.8 Tf  [(Stefania Bruno, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 534.619 Td /F1 9.8 Tf  [(Elvina Chu, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 515.214 Td /F1 9.8 Tf  [(Karen Doherty, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 495.810 Td /F1 9.8 Tf  [(Nayana Lahiri, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 476.405 Td /F1 9.8 Tf  [(Marianne Novak, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 457.000 Td /F1 9.8 Tf  [(Aakta Patel, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 437.595 Td /F1 9.8 Tf  [(Sarah Tabrizi, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 418.191 Td /F1 9.8 Tf  [(Rachel Taylor, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 398.786 Td /F1 9.8 Tf  [(Thomas Warner, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 379.381 Td /F1 9.8 Tf  [(Edward Wild, The National Hospital for Neurology and Neurosurgery, London, UK)] TJ ET
BT 26.250 359.976 Td /F1 9.8 Tf  [(Natalie Arran, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 348.072 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 328.667 Td /F1 9.8 Tf  [(David Craufurd, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 316.762 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 297.357 Td /F1 9.8 Tf  [(Ruth Fullam, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 285.453 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 266.048 Td /F1 9.8 Tf  [(Liz Howard, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 254.143 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 234.738 Td /F1 9.8 Tf  [(Susan Huson, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 222.834 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 203.429 Td /F1 9.8 Tf  [(Lucy Partington-Jones, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 191.524 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 172.119 Td /F1 9.8 Tf  [(Nichola Verstraelen \(formerly Ritchie\), Genetic Medicine, University of Manchester, Manchester Academic Health Sciences )] TJ ET
BT 26.250 160.215 Td /F1 9.8 Tf  [(Centre and Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 140.810 Td /F1 9.8 Tf  [(Julie Snowden, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 128.905 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 109.500 Td /F1 9.8 Tf  [(Andrea Sollom, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 97.596 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 78.191 Td /F1 9.8 Tf  [(Cheryl Stopford, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 66.286 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 46.881 Td /F1 9.8 Tf  [(Jennifer Thompson, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
Q
q
0.000 0.000 0.000 rg
BT 291.710 19.825 Td /F1 11.0 Tf  [(13)] TJ ET
BT 25.000 19.825 Td /F1 11.0 Tf  [(PLOS Currents Huntington Disease)] TJ ET

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BT 26.250 767.476 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(Leann Westmoreland, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 736.167 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 716.762 Td /F1 9.8 Tf  [(Andrea H Nemeth, Oxford Radcliffe Hospitals NHS Trust, Oxford, UK)] TJ ET
BT 26.250 697.357 Td /F1 9.8 Tf  [(Gill Siuda, Oxford Radcliffe Hospitals NHS Trust, Oxford, UK)] TJ ET
BT 26.250 677.952 Td /F1 9.8 Tf  [(Oliver Bandmann, The Royal Hallamshire Hospital, Sheffield, UK)] TJ ET
BT 26.250 658.548 Td /F1 9.8 Tf  [(Alyson Bradbury, The Royal Hallamshire Hospital, Sheffield, UK)] TJ ET
BT 26.250 639.143 Td /F1 9.8 Tf  [(Kay Fillingham, The Royal Hallamshire Hospital, Sheffield, UK)] TJ ET
BT 26.250 619.738 Td /F1 9.8 Tf  [(Isabella Foustanos, The Royal Hallamshire Hospital, Sheffield, UK)] TJ ET
BT 26.250 600.333 Td /F1 9.8 Tf  [(Katherine Tidswell,The Royal Hallamshire Hospital, Sheffield, UK)] TJ ET
BT 26.250 580.929 Td /F1 9.8 Tf  [(Oliver Quarrell, The Royal Hallamshire Hospital, Sheffield, UK)] TJ ET
BT 26.250 544.326 Td /F4 12.0 Tf  [(References)] TJ ET
BT 26.250 516.872 Td /F1 9.8 Tf  [(1.)] TJ ET
BT 38.132 516.872 Td /F1 9.8 Tf  [(A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The )] TJ ET
BT 26.250 504.967 Td /F1 9.8 Tf  [(Huntington's Disease Collaborative Research Group. Cell 1993;72\(6\):971-83)] TJ ET
BT 26.250 485.562 Td /F1 9.8 Tf  [(2.)] TJ ET
BT 38.132 485.562 Td /F1 9.8 Tf  [(Wexler NS, Lorimer J, Porter J, et al. Venezuelan kindreds reveal that genetic and environmental factors modulate )] TJ ET
BT 26.250 473.658 Td /F1 9.8 Tf  [(Huntington's disease age of onset. Proc Natl Acad Sci U S A 2004;101\(10\):3498-503)] TJ ET
BT 26.250 454.253 Td /F1 9.8 Tf  [(3.)] TJ ET
BT 38.132 454.253 Td /F1 9.8 Tf  [(Rubinsztein DC, Leggo J, Chiano M, et al. Genotypes at the GluR6 kainate receptor locus are associated with variation in the )] TJ ET
BT 26.250 442.348 Td /F1 9.8 Tf  [(age of onset of Huntington disease. Proc Natl Acad Sci USA 1997;94:3872�6)] TJ ET
BT 26.250 422.943 Td /F1 9.8 Tf  [(4.)] TJ ET
BT 38.132 422.943 Td /F1 9.8 Tf  [(Arning L, Saft C, Wieczorek S, et al. NR2A and NR2B receptor gene variations modify age at onset in Huntington disease in )] TJ ET
BT 26.250 411.039 Td /F1 9.8 Tf  [(a sex-specific manner. Hum Genet 2007;122\(2\):175-82)] TJ ET
BT 26.250 391.634 Td /F1 9.8 Tf  [(5.)] TJ ET
BT 38.132 391.634 Td /F1 9.8 Tf  [(Andresen JM, Gayan J, Cherny SS, et al. Replication of twelve association studies for Huntington's disease residual age of )] TJ ET
BT 26.250 379.729 Td /F1 9.8 Tf  [(onset in large Venezuelan kindreds. J Med Genet 2007;44\(1\):44-50)] TJ ET
BT 26.250 360.324 Td /F1 9.8 Tf  [(6.)] TJ ET
BT 38.132 360.324 Td /F1 9.8 Tf  [(Weydt P, Soyal SM, Gellera C, et al. The gene coding for PGC-1alpha modifies age at onset in Huntington's Disease.Mol )] TJ ET
BT 26.250 348.420 Td /F1 9.8 Tf  [(Neurodegener 2009;4:3)] TJ ET
BT 26.250 329.015 Td /F1 9.8 Tf  [(7.)] TJ ET
BT 38.132 329.015 Td /F1 9.8 Tf  [(Taherzadeh-Fard E, Saft C, Andrich J, et al. PGC-1alpha as modifier of onset age in Huntington disease. Mol Neurodegener )] TJ ET
BT 26.250 317.110 Td /F1 9.8 Tf  [(2009;4:10)] TJ ET
BT 26.250 297.705 Td /F1 9.8 Tf  [(8.)] TJ ET
BT 38.132 297.705 Td /F1 9.8 Tf  [(Gusella JF, MacDonald ME. Huntington's disease: the case for genetic modifiers. Genome Med 2009;1\(8\):80)] TJ ET
BT 26.250 278.301 Td /F1 9.8 Tf  [(9.)] TJ ET
BT 38.132 278.301 Td /F1 9.8 Tf  [(Arning L, Haghikia A, Taherzadeh-Fard E, et al. Mitochondrial haplogroup H correlates with ATP levels and age at onset in )] TJ ET
BT 26.250 266.396 Td /F1 9.8 Tf  [(Huntington disease. J Mol Med 2010;88\(4\):431-6)] TJ ET
BT 26.250 246.991 Td /F1 9.8 Tf  [(10.)] TJ ET
BT 43.553 246.991 Td /F1 9.8 Tf  [(Orth M, Handley OJ, Schwenke C, et al. Observing Huntington's Disease: the European Huntington's Disease Network's )] TJ ET
BT 26.250 235.086 Td /F1 9.8 Tf  [(REGISTRY. PLoS Curr;2)] TJ ET
Q
q
15.000 217.706 577.500 559.294 re W n
0.271 0.267 0.267 rg
BT 26.250 767.476 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(Leann Westmoreland, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 736.167 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 716.762 Td /F1 9.8 Tf  [(Andrea H Nemeth, Oxford Radcliffe Hospitals NHS Trust, Oxford, UK)] TJ ET
BT 26.250 697.357 Td /F1 9.8 Tf  [(Gill Siuda, Oxford Radcliffe Hospitals NHS Trust, Oxford, UK)] TJ ET
BT 26.250 677.952 Td /F1 9.8 Tf  [(Oliver Bandmann, The Royal Hallamshire Hospital, Sheffield, UK)] TJ ET
BT 26.250 658.548 Td /F1 9.8 Tf  [(Alyson Bradbury, The Royal Hallamshire Hospital, Sheffield, UK)] TJ ET
BT 26.250 639.143 Td /F1 9.8 Tf  [(Kay Fillingham, The Royal Hallamshire Hospital, Sheffield, UK)] TJ ET
BT 26.250 619.738 Td /F1 9.8 Tf  [(Isabella Foustanos, The Royal Hallamshire Hospital, Sheffield, UK)] TJ ET
BT 26.250 600.333 Td /F1 9.8 Tf  [(Katherine Tidswell,The Royal Hallamshire Hospital, Sheffield, UK)] TJ ET
BT 26.250 580.929 Td /F1 9.8 Tf  [(Oliver Quarrell, The Royal Hallamshire Hospital, Sheffield, UK)] TJ ET
BT 26.250 544.326 Td /F4 12.0 Tf  [(References)] TJ ET
BT 26.250 516.872 Td /F1 9.8 Tf  [(1.)] TJ ET
BT 38.132 516.872 Td /F1 9.8 Tf  [(A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The )] TJ ET
BT 26.250 504.967 Td /F1 9.8 Tf  [(Huntington's Disease Collaborative Research Group. Cell 1993;72\(6\):971-83)] TJ ET
BT 26.250 485.562 Td /F1 9.8 Tf  [(2.)] TJ ET
BT 38.132 485.562 Td /F1 9.8 Tf  [(Wexler NS, Lorimer J, Porter J, et al. Venezuelan kindreds reveal that genetic and environmental factors modulate )] TJ ET
BT 26.250 473.658 Td /F1 9.8 Tf  [(Huntington's disease age of onset. Proc Natl Acad Sci U S A 2004;101\(10\):3498-503)] TJ ET
BT 26.250 454.253 Td /F1 9.8 Tf  [(3.)] TJ ET
BT 38.132 454.253 Td /F1 9.8 Tf  [(Rubinsztein DC, Leggo J, Chiano M, et al. Genotypes at the GluR6 kainate receptor locus are associated with variation in the )] TJ ET
BT 26.250 442.348 Td /F1 9.8 Tf  [(age of onset of Huntington disease. Proc Natl Acad Sci USA 1997;94:3872�6)] TJ ET
BT 26.250 422.943 Td /F1 9.8 Tf  [(4.)] TJ ET
BT 38.132 422.943 Td /F1 9.8 Tf  [(Arning L, Saft C, Wieczorek S, et al. NR2A and NR2B receptor gene variations modify age at onset in Huntington disease in )] TJ ET
BT 26.250 411.039 Td /F1 9.8 Tf  [(a sex-specific manner. Hum Genet 2007;122\(2\):175-82)] TJ ET
BT 26.250 391.634 Td /F1 9.8 Tf  [(5.)] TJ ET
BT 38.132 391.634 Td /F1 9.8 Tf  [(Andresen JM, Gayan J, Cherny SS, et al. Replication of twelve association studies for Huntington's disease residual age of )] TJ ET
BT 26.250 379.729 Td /F1 9.8 Tf  [(onset in large Venezuelan kindreds. J Med Genet 2007;44\(1\):44-50)] TJ ET
BT 26.250 360.324 Td /F1 9.8 Tf  [(6.)] TJ ET
BT 38.132 360.324 Td /F1 9.8 Tf  [(Weydt P, Soyal SM, Gellera C, et al. The gene coding for PGC-1alpha modifies age at onset in Huntington's Disease.Mol )] TJ ET
BT 26.250 348.420 Td /F1 9.8 Tf  [(Neurodegener 2009;4:3)] TJ ET
BT 26.250 329.015 Td /F1 9.8 Tf  [(7.)] TJ ET
BT 38.132 329.015 Td /F1 9.8 Tf  [(Taherzadeh-Fard E, Saft C, Andrich J, et al. PGC-1alpha as modifier of onset age in Huntington disease. Mol Neurodegener )] TJ ET
BT 26.250 317.110 Td /F1 9.8 Tf  [(2009;4:10)] TJ ET
BT 26.250 297.705 Td /F1 9.8 Tf  [(8.)] TJ ET
BT 38.132 297.705 Td /F1 9.8 Tf  [(Gusella JF, MacDonald ME. Huntington's disease: the case for genetic modifiers. Genome Med 2009;1\(8\):80)] TJ ET
BT 26.250 278.301 Td /F1 9.8 Tf  [(9.)] TJ ET
BT 38.132 278.301 Td /F1 9.8 Tf  [(Arning L, Haghikia A, Taherzadeh-Fard E, et al. Mitochondrial haplogroup H correlates with ATP levels and age at onset in )] TJ ET
BT 26.250 266.396 Td /F1 9.8 Tf  [(Huntington disease. J Mol Med 2010;88\(4\):431-6)] TJ ET
BT 26.250 246.991 Td /F1 9.8 Tf  [(10.)] TJ ET
BT 43.553 246.991 Td /F1 9.8 Tf  [(Orth M, Handley OJ, Schwenke C, et al. Observing Huntington's Disease: the European Huntington's Disease Network's )] TJ ET
BT 26.250 235.086 Td /F1 9.8 Tf  [(REGISTRY. PLoS Curr;2)] TJ ET
Q
q
15.000 217.706 577.500 559.294 re W n
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BT 26.250 767.476 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 748.071 Td /F1 9.8 Tf  [(Leann Westmoreland, Genetic Medicine, University of Manchester, Manchester Academic Health Sciences Centre and Central )] TJ ET
BT 26.250 736.167 Td /F1 9.8 Tf  [(Manchester University Hospitals NHS Foundation Trust, Manchester, UK)] TJ ET
BT 26.250 716.762 Td /F1 9.8 Tf  [(Andrea H Nemeth, Oxford Radcliffe Hospitals NHS Trust, Oxford, UK)] TJ ET
BT 26.250 697.357 Td /F1 9.8 Tf  [(Gill Siuda, Oxford Radcliffe Hospitals NHS Trust, Oxford, UK)] TJ ET
BT 26.250 677.952 Td /F1 9.8 Tf  [(Oliver Bandmann, The Royal Hallamshire Hospital, Sheffield, UK)] TJ ET
BT 26.250 658.548 Td /F1 9.8 Tf  [(Alyson Bradbury, The Royal Hallamshire Hospital, Sheffield, UK)] TJ ET
BT 26.250 639.143 Td /F1 9.8 Tf  [(Kay Fillingham, The Royal Hallamshire Hospital, Sheffield, UK)] TJ ET
BT 26.250 619.738 Td /F1 9.8 Tf  [(Isabella Foustanos, The Royal Hallamshire Hospital, Sheffield, UK)] TJ ET
BT 26.250 600.333 Td /F1 9.8 Tf  [(Katherine Tidswell,The Royal Hallamshire Hospital, Sheffield, UK)] TJ ET
BT 26.250 580.929 Td /F1 9.8 Tf  [(Oliver Quarrell, The Royal Hallamshire Hospital, Sheffield, UK)] TJ ET
BT 26.250 544.326 Td /F4 12.0 Tf  [(References)] TJ ET
BT 26.250 516.872 Td /F1 9.8 Tf  [(1.)] TJ ET
BT 38.132 516.872 Td /F1 9.8 Tf  [(A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The )] TJ ET
BT 26.250 504.967 Td /F1 9.8 Tf  [(Huntington's Disease Collaborative Research Group. Cell 1993;72\(6\):971-83)] TJ ET
BT 26.250 485.562 Td /F1 9.8 Tf  [(2.)] TJ ET
BT 38.132 485.562 Td /F1 9.8 Tf  [(Wexler NS, Lorimer J, Porter J, et al. Venezuelan kindreds reveal that genetic and environmental factors modulate )] TJ ET
BT 26.250 473.658 Td /F1 9.8 Tf  [(Huntington's disease age of onset. Proc Natl Acad Sci U S A 2004;101\(10\):3498-503)] TJ ET
BT 26.250 454.253 Td /F1 9.8 Tf  [(3.)] TJ ET
BT 38.132 454.253 Td /F1 9.8 Tf  [(Rubinsztein DC, Leggo J, Chiano M, et al. Genotypes at the GluR6 kainate receptor locus are associated with variation in the )] TJ ET
BT 26.250 442.348 Td /F1 9.8 Tf  [(age of onset of Huntington disease. Proc Natl Acad Sci USA 1997;94:3872�6)] TJ ET
BT 26.250 422.943 Td /F1 9.8 Tf  [(4.)] TJ ET
BT 38.132 422.943 Td /F1 9.8 Tf  [(Arning L, Saft C, Wieczorek S, et al. NR2A and NR2B receptor gene variations modify age at onset in Huntington disease in )] TJ ET
BT 26.250 411.039 Td /F1 9.8 Tf  [(a sex-specific manner. Hum Genet 2007;122\(2\):175-82)] TJ ET
BT 26.250 391.634 Td /F1 9.8 Tf  [(5.)] TJ ET
BT 38.132 391.634 Td /F1 9.8 Tf  [(Andresen JM, Gayan J, Cherny SS, et al. Replication of twelve association studies for Huntington's disease residual age of )] TJ ET
BT 26.250 379.729 Td /F1 9.8 Tf  [(onset in large Venezuelan kindreds. J Med Genet 2007;44\(1\):44-50)] TJ ET
BT 26.250 360.324 Td /F1 9.8 Tf  [(6.)] TJ ET
BT 38.132 360.324 Td /F1 9.8 Tf  [(Weydt P, Soyal SM, Gellera C, et al. The gene coding for PGC-1alpha modifies age at onset in Huntington's Disease.Mol )] TJ ET
BT 26.250 348.420 Td /F1 9.8 Tf  [(Neurodegener 2009;4:3)] TJ ET
BT 26.250 329.015 Td /F1 9.8 Tf  [(7.)] TJ ET
BT 38.132 329.015 Td /F1 9.8 Tf  [(Taherzadeh-Fard E, Saft C, Andrich J, et al. PGC-1alpha as modifier of onset age in Huntington disease. Mol Neurodegener )] TJ ET
BT 26.250 317.110 Td /F1 9.8 Tf  [(2009;4:10)] TJ ET
BT 26.250 297.705 Td /F1 9.8 Tf  [(8.)] TJ ET
BT 38.132 297.705 Td /F1 9.8 Tf  [(Gusella JF, MacDonald ME. Huntington's disease: the case for genetic modifiers. Genome Med 2009;1\(8\):80)] TJ ET
BT 26.250 278.301 Td /F1 9.8 Tf  [(9.)] TJ ET
BT 38.132 278.301 Td /F1 9.8 Tf  [(Arning L, Haghikia A, Taherzadeh-Fard E, et al. Mitochondrial haplogroup H correlates with ATP levels and age at onset in )] TJ ET
BT 26.250 266.396 Td /F1 9.8 Tf  [(Huntington disease. J Mol Med 2010;88\(4\):431-6)] TJ ET
BT 26.250 246.991 Td /F1 9.8 Tf  [(10.)] TJ ET
BT 43.553 246.991 Td /F1 9.8 Tf  [(Orth M, Handley OJ, Schwenke C, et al. Observing Huntington's Disease: the European Huntington's Disease Network's )] TJ ET
BT 26.250 235.086 Td /F1 9.8 Tf  [(REGISTRY. PLoS Curr;2)] TJ ET
Q
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BT 291.710 19.825 Td /F1 11.0 Tf  [(14)] TJ ET
BT 25.000 19.825 Td /F1 11.0 Tf  [(PLOS Currents Huntington Disease)] TJ ET

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