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The Prevalence of Juvenile Huntington s Disease: A Review )] TJ ET BT 568.370 557.761 Td /F1 9.8 Tf [(of )] TJ ET BT 26.250 542.317 Td /F1 9.8 Tf [(the Literature and Meta-Analysis. PLOS Currents Huntington Disease. 2012 Jul 20 [last modified: 2012 Aug 3]. )] TJ ET BT 26.250 526.873 Td /F1 9.8 Tf [(Edition 1. doi: 10.1371/4f8606b742ef3.)] TJ ET q 15.000 29.492 577.500 494.292 re W n 0.271 0.267 0.267 rg BT 26.250 493.577 Td /F4 12.0 Tf [(Abstract)] TJ ET BT 26.250 469.921 Td /F1 9.8 Tf [(Juvenile Huntington s disease \(JHD\) is usually defined as Huntington s disease with an onset "d 20 years. The )] TJ ET BT 26.250 454.477 Td /F1 9.8 Tf [(proportion of JHD cases reported in studies of Huntington s disease \(HD\) varies. A review of the literature found )] TJ ET BT 26.250 439.033 Td /F1 9.8 Tf [(62 studies that reported the proportion of JHD cases amongst all HD cases. The proportion of JHD cases in these )] TJ ET BT 26.250 423.589 Td /F1 9.8 Tf [(studies ranged from 1% to 15%, and in a meta-analysis the pooled proportion of JHD cases was 4.92% \(95% )] TJ ET BT 26.250 408.145 Td /F1 9.8 Tf [(confidence interval of 4.07% to 5.84%\). Limiting the analysis to the 25 studies which used multiple methods of )] TJ ET BT 26.250 392.701 Td /F1 9.8 Tf [(ascertainment resulted in a similar pooled proportion of 5.32%, \(95% confidence interval 4.18% to 6.60%\).)] TJ ET BT 26.250 369.757 Td /F1 9.8 Tf [(A small difference was observed when the meta-analysis was restricted to studies from countries defined by the )] TJ ET BT 26.250 354.313 Td /F1 9.8 Tf [(World Bank as high income, that used multiple methods of ascertainment, and that were conducted since 1980 )] TJ ET BT 26.250 338.869 Td /F1 9.8 Tf [(\(4.81%, 95% confidence interval 3.31% to 6.58%, n=11\). This contrasts with the pooled result from three post )] TJ ET BT 26.250 323.425 Td /F1 9.8 Tf [(1980 studies using multiple methods of ascertainment from South Africa and Venezuela, defined by the World )] TJ ET BT 26.250 307.981 Td /F1 9.8 Tf [(Bank as upper middle income, where the estimated mean proportion was 9.95%, \(95% confidence interval )] TJ ET BT 26.250 292.537 Td /F1 9.8 Tf [(6.37% to 14.22%\).)] TJ ET BT 26.250 269.593 Td /F1 9.8 Tf [(These results, which are expected to be more robust than those from a single study alone, may be helpful in )] TJ ET BT 26.250 254.149 Td /F1 9.8 Tf [(estimating the proportion of JHD cases in a given population.)] TJ ET BT 26.250 231.205 Td /F1 9.8 Tf [(Key Words: Juvenile Huntington s disease, prevalence, epidemiology)] TJ ET BT 26.250 190.409 Td /F4 12.0 Tf [(Funding Statement)] TJ ET BT 26.250 166.753 Td /F1 9.8 Tf [(Mark Strong and Oliver Bandmann, University of Sheffield; Oliver Quarrell and Kirsty L O Donovan, Sheffield )] TJ ET BT 26.250 151.309 Td /F1 9.8 Tf [(Children s NHS Trust.)] TJ ET BT 26.250 118.013 Td /F4 12.0 Tf [(Introduction)] TJ ET BT 26.250 94.357 Td /F1 9.8 Tf [(Huntington s disease \(HD\) is an autosomal dominant, neurodegenerative disorder with onset usually, but not )] TJ ET BT 26.250 78.913 Td /F1 9.8 Tf [(exclusively, between 35 and 50 years of age)] TJ ET 0.267 0.267 0.267 rg BT 244.826 80.868 Td /F4 8.7 Tf [(1)] TJ ET 0.271 0.267 0.267 rg BT 250.858 78.913 Td /F1 9.8 Tf [( . Onset ? the age of 20 is classified as juvenile onset Huntington s )] TJ ET BT 26.250 63.469 Td /F1 9.8 Tf [(disease \(JHD\), which can be further divided into childhood \(0-10 years\) and adolescent \(11-20 years\) onset. )] TJ ET BT 26.250 48.025 Td /F1 9.8 Tf [(Although there are many similarities with the adult form of the disease, JHD has a clinically distinct )] TJ ET Q q 15.000 636.553 577.500 101.447 re W n 0.267 0.267 0.267 rg BT 15.000 711.948 Td /F2 21.0 Tf [(The Prevalence of Juvenile Huntington s )] TJ ET BT 15.000 679.382 Td /F2 21.0 Tf [(Disease: A Review of the Literature and Meta-)] TJ ET BT 15.000 646.816 Td /F2 21.0 Tf [(Analysis)] TJ ET Q 0.271 0.267 0.267 rg BT 15.000 624.568 Td /F3 9.8 Tf [(July 20, 2012)] TJ ET BT 86.526 624.568 Td /F3 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg BT 92.727 624.568 Td /F3 9.8 Tf [(Huntington Disease)] TJ ET BT 26.250 609.217 Td /F1 9.8 Tf [(Oliver Quarrell)] TJ ET 0.271 0.267 0.267 rg BT 97.484 614.261 Td /F1 8.7 Tf [(1)] TJ ET BT 102.996 609.217 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 109.197 609.217 Td /F1 9.8 Tf [(Kirsty L O'Donovan)] TJ ET 0.271 0.267 0.267 rg BT 202.524 614.261 Td /F1 8.7 Tf [(1)] TJ ET BT 208.036 609.217 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 214.237 609.217 Td /F1 9.8 Tf [(Oliver Bandmann)] TJ ET 0.271 0.267 0.267 rg BT 299.081 609.217 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 305.282 609.217 Td /F1 9.8 Tf [(Mark Strong)] TJ ET 0.271 0.267 0.267 rg BT 364.786 614.261 Td /F1 8.7 Tf [(2)] TJ ET BT 26.250 594.723 Td /F4 9.0 Tf [(1)] TJ ET BT 32.514 594.723 Td /F1 9.0 Tf [( Department of Clinical Genetics, Sheffield Children's Hospital, Sheffield UK S10 2TH, )] TJ ET BT 418.740 594.723 Td /F4 9.0 Tf [(2)] TJ ET BT 425.004 594.723 Td /F1 9.0 Tf [( School of Health and Related )] TJ ET BT 26.250 580.467 Td /F1 9.0 Tf [(Research, University of Sheffield, Regent Court, 30 Regent Street, Sheffield, UK, S1 4DA)] TJ ET BT 26.250 557.761 Td /F1 9.8 Tf [(Quarrell O, O'Donovan KL, Bandmann O, Strong M. The Prevalence of Juvenile Huntington s Disease: A Review )] TJ ET BT 568.370 557.761 Td /F1 9.8 Tf [(of )] TJ ET BT 26.250 542.317 Td /F1 9.8 Tf [(the Literature and Meta-Analysis. PLOS Currents Huntington Disease. 2012 Jul 20 [last modified: 2012 Aug 3]. )] TJ ET BT 26.250 526.873 Td /F1 9.8 Tf [(Edition 1. doi: 10.1371/4f8606b742ef3.)] TJ ET q 15.000 29.492 577.500 494.292 re W n 0.271 0.267 0.267 rg BT 26.250 493.577 Td /F4 12.0 Tf [(Abstract)] TJ ET BT 26.250 469.921 Td /F1 9.8 Tf [(Juvenile Huntington s disease \(JHD\) is usually defined as Huntington s disease with an onset "d 20 years. The )] TJ ET BT 26.250 454.477 Td /F1 9.8 Tf [(proportion of JHD cases reported in studies of Huntington s disease \(HD\) varies. A review of the literature found )] TJ ET BT 26.250 439.033 Td /F1 9.8 Tf [(62 studies that reported the proportion of JHD cases amongst all HD cases. The proportion of JHD cases in these )] TJ ET BT 26.250 423.589 Td /F1 9.8 Tf [(studies ranged from 1% to 15%, and in a meta-analysis the pooled proportion of JHD cases was 4.92% \(95% )] TJ ET BT 26.250 408.145 Td /F1 9.8 Tf [(confidence interval of 4.07% to 5.84%\). Limiting the analysis to the 25 studies which used multiple methods of )] TJ ET BT 26.250 392.701 Td /F1 9.8 Tf [(ascertainment resulted in a similar pooled proportion of 5.32%, \(95% confidence interval 4.18% to 6.60%\).)] TJ ET BT 26.250 369.757 Td /F1 9.8 Tf [(A small difference was observed when the meta-analysis was restricted to studies from countries defined by the )] TJ ET BT 26.250 354.313 Td /F1 9.8 Tf [(World Bank as high income, that used multiple methods of ascertainment, and that were conducted since 1980 )] TJ ET BT 26.250 338.869 Td /F1 9.8 Tf [(\(4.81%, 95% confidence interval 3.31% to 6.58%, n=11\). This contrasts with the pooled result from three post )] TJ ET BT 26.250 323.425 Td /F1 9.8 Tf [(1980 studies using multiple methods of ascertainment from South Africa and Venezuela, defined by the World )] TJ ET BT 26.250 307.981 Td /F1 9.8 Tf [(Bank as upper middle income, where the estimated mean proportion was 9.95%, \(95% confidence interval )] TJ ET BT 26.250 292.537 Td /F1 9.8 Tf [(6.37% to 14.22%\).)] TJ ET BT 26.250 269.593 Td /F1 9.8 Tf [(These results, which are expected to be more robust than those from a single study alone, may be helpful in )] TJ ET BT 26.250 254.149 Td /F1 9.8 Tf [(estimating the proportion of JHD cases in a given population.)] TJ ET BT 26.250 231.205 Td /F1 9.8 Tf [(Key Words: Juvenile Huntington s disease, prevalence, epidemiology)] TJ ET BT 26.250 190.409 Td /F4 12.0 Tf [(Funding Statement)] TJ ET BT 26.250 166.753 Td /F1 9.8 Tf [(Mark Strong and Oliver Bandmann, University of Sheffield; Oliver Quarrell and Kirsty L O Donovan, Sheffield )] TJ ET BT 26.250 151.309 Td /F1 9.8 Tf [(Children s NHS Trust.)] TJ ET BT 26.250 118.013 Td /F4 12.0 Tf [(Introduction)] TJ ET BT 26.250 94.357 Td /F1 9.8 Tf [(Huntington s disease \(HD\) is an autosomal dominant, neurodegenerative disorder with onset usually, but not )] TJ ET BT 26.250 78.913 Td /F1 9.8 Tf [(exclusively, between 35 and 50 years of age)] TJ ET 0.267 0.267 0.267 rg BT 244.826 80.868 Td /F4 8.7 Tf [(1)] TJ ET 0.271 0.267 0.267 rg BT 250.858 78.913 Td /F1 9.8 Tf [( . Onset ? the age of 20 is classified as juvenile onset Huntington s )] TJ ET BT 26.250 63.469 Td /F1 9.8 Tf [(disease \(JHD\), which can be further divided into childhood \(0-10 years\) and adolescent \(11-20 years\) onset. )] TJ ET BT 26.250 48.025 Td /F1 9.8 Tf [(Although there are many similarities with the adult form of the disease, JHD has a clinically distinct )] TJ ET Q q 15.000 636.553 577.500 101.447 re W n 0.267 0.267 0.267 rg BT 15.000 711.948 Td /F2 21.0 Tf [(The Prevalence of Juvenile Huntington s )] TJ ET BT 15.000 679.382 Td /F2 21.0 Tf [(Disease: A Review of the Literature and Meta-)] TJ ET BT 15.000 646.816 Td /F2 21.0 Tf [(Analysis)] TJ ET Q 0.271 0.267 0.267 rg BT 15.000 624.568 Td /F3 9.8 Tf [(July 20, 2012)] TJ ET BT 86.526 624.568 Td /F3 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg BT 92.727 624.568 Td /F3 9.8 Tf [(Huntington Disease)] TJ ET BT 26.250 609.217 Td /F1 9.8 Tf [(Oliver Quarrell)] TJ ET 0.271 0.267 0.267 rg BT 97.484 614.261 Td /F1 8.7 Tf [(1)] TJ ET BT 102.996 609.217 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 109.197 609.217 Td /F1 9.8 Tf [(Kirsty L O'Donovan)] TJ ET 0.271 0.267 0.267 rg BT 202.524 614.261 Td /F1 8.7 Tf [(1)] TJ ET BT 208.036 609.217 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 214.237 609.217 Td /F1 9.8 Tf [(Oliver Bandmann)] TJ ET 0.271 0.267 0.267 rg BT 299.081 609.217 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 305.282 609.217 Td /F1 9.8 Tf [(Mark Strong)] TJ ET 0.271 0.267 0.267 rg BT 364.786 614.261 Td /F1 8.7 Tf [(2)] TJ ET BT 26.250 594.723 Td /F4 9.0 Tf [(1)] TJ ET BT 32.514 594.723 Td /F1 9.0 Tf [( Department of Clinical Genetics, Sheffield Children's Hospital, Sheffield UK S10 2TH, )] TJ ET BT 418.740 594.723 Td /F4 9.0 Tf [(2)] TJ ET BT 425.004 594.723 Td /F1 9.0 Tf [( School of Health and Related )] TJ ET BT 26.250 580.467 Td /F1 9.0 Tf [(Research, University of Sheffield, Regent Court, 30 Regent Street, Sheffield, UK, S1 4DA)] TJ ET BT 26.250 557.761 Td /F1 9.8 Tf [(Quarrell O, O'Donovan KL, Bandmann O, Strong M. The Prevalence of Juvenile Huntington s Disease: A Review )] TJ ET BT 568.370 557.761 Td /F1 9.8 Tf [(of )] TJ ET BT 26.250 542.317 Td /F1 9.8 Tf [(the Literature and Meta-Analysis. PLOS Currents Huntington Disease. 2012 Jul 20 [last modified: 2012 Aug 3]. )] TJ ET BT 26.250 526.873 Td /F1 9.8 Tf [(Edition 1. doi: 10.1371/4f8606b742ef3.)] TJ ET q 15.000 29.492 577.500 494.292 re W n 0.271 0.267 0.267 rg BT 26.250 493.577 Td /F4 12.0 Tf [(Abstract)] TJ ET BT 26.250 469.921 Td /F1 9.8 Tf [(Juvenile Huntington s disease \(JHD\) is usually defined as Huntington s disease with an onset "d 20 years. The )] TJ ET BT 26.250 454.477 Td /F1 9.8 Tf [(proportion of JHD cases reported in studies of Huntington s disease \(HD\) varies. A review of the literature found )] TJ ET BT 26.250 439.033 Td /F1 9.8 Tf [(62 studies that reported the proportion of JHD cases amongst all HD cases. The proportion of JHD cases in these )] TJ ET BT 26.250 423.589 Td /F1 9.8 Tf [(studies ranged from 1% to 15%, and in a meta-analysis the pooled proportion of JHD cases was 4.92% \(95% )] TJ ET BT 26.250 408.145 Td /F1 9.8 Tf [(confidence interval of 4.07% to 5.84%\). Limiting the analysis to the 25 studies which used multiple methods of )] TJ ET BT 26.250 392.701 Td /F1 9.8 Tf [(ascertainment resulted in a similar pooled proportion of 5.32%, \(95% confidence interval 4.18% to 6.60%\).)] TJ ET BT 26.250 369.757 Td /F1 9.8 Tf [(A small difference was observed when the meta-analysis was restricted to studies from countries defined by the )] TJ ET BT 26.250 354.313 Td /F1 9.8 Tf [(World Bank as high income, that used multiple methods of ascertainment, and that were conducted since 1980 )] TJ ET BT 26.250 338.869 Td /F1 9.8 Tf [(\(4.81%, 95% confidence interval 3.31% to 6.58%, n=11\). This contrasts with the pooled result from three post )] TJ ET BT 26.250 323.425 Td /F1 9.8 Tf [(1980 studies using multiple methods of ascertainment from South Africa and Venezuela, defined by the World )] TJ ET BT 26.250 307.981 Td /F1 9.8 Tf [(Bank as upper middle income, where the estimated mean proportion was 9.95%, \(95% confidence interval )] TJ ET BT 26.250 292.537 Td /F1 9.8 Tf [(6.37% to 14.22%\).)] TJ ET BT 26.250 269.593 Td /F1 9.8 Tf [(These results, which are expected to be more robust than those from a single study alone, may be helpful in )] TJ ET BT 26.250 254.149 Td /F1 9.8 Tf [(estimating the proportion of JHD cases in a given population.)] TJ ET BT 26.250 231.205 Td /F1 9.8 Tf [(Key Words: Juvenile Huntington s disease, prevalence, epidemiology)] TJ ET BT 26.250 190.409 Td /F4 12.0 Tf [(Funding Statement)] TJ ET BT 26.250 166.753 Td /F1 9.8 Tf [(Mark Strong and Oliver Bandmann, University of Sheffield; Oliver Quarrell and Kirsty L O Donovan, Sheffield )] TJ ET BT 26.250 151.309 Td /F1 9.8 Tf [(Children s NHS Trust.)] TJ ET BT 26.250 118.013 Td /F4 12.0 Tf [(Introduction)] TJ ET BT 26.250 94.357 Td /F1 9.8 Tf [(Huntington s disease \(HD\) is an autosomal dominant, neurodegenerative disorder with onset usually, but not )] TJ ET BT 26.250 78.913 Td /F1 9.8 Tf [(exclusively, between 35 and 50 years of age)] TJ ET 0.267 0.267 0.267 rg BT 244.826 80.868 Td /F4 8.7 Tf [(1)] TJ ET 0.271 0.267 0.267 rg BT 250.858 78.913 Td /F1 9.8 Tf [( . Onset ? the age of 20 is classified as juvenile onset Huntington s )] TJ ET BT 26.250 63.469 Td /F1 9.8 Tf [(disease \(JHD\), which can be further divided into childhood \(0-10 years\) and adolescent \(11-20 years\) onset. )] TJ ET BT 26.250 48.025 Td /F1 9.8 Tf [(Although there are many similarities with the adult form of the disease, JHD has a clinically distinct )] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 18.032 Td /F5 11.0 Tf [(1)] TJ ET BT 25.000 18.032 Td /F5 11.0 Tf [(PLOS Currents Huntington Disease)] TJ ET Q endstream endobj 8 0 obj <> endobj 9 0 obj <> stream /CIDInit /ProcSet findresource begin 12 dict begin begincmap /CIDSystemInfo <> def /CMapName /Adobe-Identity-UCS def /CMapType 2 def 1 begincodespacerange <0000> endcodespacerange 1 beginbfrange <0000> <0000> endbfrange endcmap CMapName currentdict /CMap defineresource pop end endendstream endobj 10 0 obj <> endobj 11 0 obj <> endobj 12 0 obj << /Filter /FlateDecode /Length 10084>> stream x(`I-˒%_7;;ٙd3歾sdKt}Tt'`` ` .@<p <"H 2h :bX 6x >HD 1Hd 9HRT 5H҂t =2L 3l ;r\ 7| ?( B0(b8(JR4(ʂr<*J2j:jZUuA=P4 A#4MA3-A+mA;tA't]A7=A/}A?  0 C00#(0c80L$0LS403,0s<0, ",K2+*k:l&l[6;.{>!pG1p')pg9p\%p\W5p7-pw=p<#<O3/+o;|'|_7B14 !dC (aC`8Fa$FQa4ƀ1a,Ɓqa<& a"&Ia2)a*ia:fa&fYa69a.ya>a!XEa1X%a)Xea9XVa%XVUa5Xր5a-Xցua=X6 a#6Ma3-a+ma;va'v]a7=a/}a? 8C08#(8c88N$8NS48΀3,8΁s<8. 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utuuuvvlvvww`wwxLxxy@yzz{{H{|,|}8~~x8t,D\8H \xx,@\x,@\x,Hl 8l@l Lx<`<h0l@l Lx<`<h0l Lx(\,P|<p @|(l@l Lx<`<h0l Lx(\,P|<p @|(l Lx(\,P|<p @|(lH|L,h @|(l\ lL\$4p<p d$lTàĤ8`tȀ@PɌ $<T$@̐TtTdPѴҀҼ(lӴL@l8|@ؔ`ڴ۔d4݀XޠDlߔ߼@lH 8` ,p$`X \D,d@h\  LPpxp<8d,8H$8|\( dt 0 @      4     0 @ X p     0H`x 8Ph(@Xp0H`x 8Ph(@P`p\ $<lT0tX XHX Hp(Lp  @ T  ! !<!!"\""###$,%%&@&'0'x'(P()D)))*(*P**+4+,p--p-.T./x/0<001h111242D2l233,3X3334D4p44445505D5X5l55555666,6@6T6x666669>?|@<@ABC(CDtE<ETEEFFpFFGGTGGHHHH`HxHHHHHII I8IPIhIIIIIIJJ(J@JXJpJJJJJKKK0KHKKKKKLLL0LHL`LxLLLLLMM M8MPMhMMMMMMNN(N@NXNpNNNNNOOO0OHO`OxOOOOOPP P8PPPhPPPPPPQQ(Q8QQRRR4RLRdR|RRRRRS S$S4SSSST TTTTTUU(U@UXUpUUUVVV0V0V0V0V0V0V0V0V0V0V0V0V0V0V0V0V0VXVVWW$W<WPWWWWWWXXX0XHX\XtXXXXXXYY,YDY\YtYYYYZZZ0ZHZ`ZxZZZZZ[[ [8[P[h[[[\<\](]@]X]p]]]^^,^<^^^^_`4``aaa4aDb bcPchccccdDde4eLede|eef,fgg,gDg\gtggggghhh4hDii|jjjjkkkl llllmm mnTnnoop<pTplppppppqq,qqqqqqqrtrrrsss8s`ssstt0tXttttu$uLutuuuvv@vhvvvww8w`wwwxx,xTxxxxy yHytyyyzz@zhzzz{ {4{`{{{||(|T|||||} }H}p}}}~~@~h~~~4\(tpxDtl@X4H(d<DD|dT(8HXhx(8HXhx(8HXhx(dD@|X$4DTdtd Xx4(HDxt0$@8̴hҜԜT`hx40lH<0hd   P D`T!$t%')+.P1 457:<?\BLE|EFlGGHIIIJJK8KdK|KKLL$L\LLLMNTNOOOOP P\P|PPPPQQQ4QLQdQ|QQQQQRR<R\RSLSSSST T(TDT`T|TTTTUU$U@U\UxUUUUVV8VPVVVVWW$WDW\WWWWXX4XXXXY8YTYlYYYYYYZZLZZ[T[\\]\]]^$^P^^_D__`$`a|b b|bc,cdhee`ef f|fg<gh@hiPijtjkDklLlmnnlno\op|pq,qqrxrstHtuTuv$vw`wxHxxydyzPz{\{|0||}0}}~T~4$8\4X<(@Xx 8Pp(@Xp8Xx 8Pl 8Ph(@Xp0H`x8PhT+h >2   : `   (Z4;b ;; 0    " F m " : %: h: ; ;Copyright (c) 2003 by Bitstream, Inc. All Rights Reserved. Copyright (c) 2006 by Tavmjong Bah. All Rights Reserved. DejaVu changes are in public domain Copyright (c) 2003 by Bitstream, Inc. All Rights Reserved. Copyright (c) 2006 by Tavmjong Bah. All Rights Reserved. DejaVu changes are in public domain DejaVu SansDejaVu SansBookBookDejaVu SansDejaVu SansDejaVu SansDejaVu SansVersion 2.32Version 2.32DejaVuSansDejaVuSansDejaVu fonts teamDejaVu fonts teamhttp://dejavu.sourceforge.nethttps://dejavu.sourceforge.netFonts are (c) Bitstream (see below). DejaVu changes are in public domain. Glyphs imported from Arev fonts are (c) Tavmjung Bah (see below) Bitstream Vera Fonts Copyright ------------------------------ Copyright (c) 2003 by Bitstream, Inc. All Rights Reserved. Bitstream Vera is a trademark of Bitstream, Inc. Permission is hereby granted, free of charge, to any person obtaining a copy of the fonts accompanying this license ("Fonts") and associated documentation files (the "Font Software"), to reproduce and distribute the Font Software, including without limitation the rights to use, copy, merge, publish, distribute, and/or sell copies of the Font Software, and to permit persons to whom the Font Software is furnished to do so, subject to the following conditions: The above copyright and trademark notices and this permission notice shall be included in all copies of one or more of the Font Software typefaces. The Font Software may be modified, altered, or added to, and in particular the designs of glyphs or characters in the Fonts may be modified and additional glyphs or characters may be added to the Fonts, only if the fonts are renamed to names not containing either the words "Bitstream" or the word "Vera". This License becomes null and void to the extent applicable to Fonts or Font Software that has been modified and is distributed under the "Bitstream Vera" names. The Font Software may be sold as part of a larger software package but no copy of one or more of the Font Software typefaces may be sold by itself. THE FONT SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT OF COPYRIGHT, PATENT, TRADEMARK, OR OTHER RIGHT. IN NO EVENT SHALL BITSTREAM OR THE GNOME FOUNDATION BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, INCLUDING ANY GENERAL, SPECIAL, INDIRECT, INCIDENTAL, OR CONSEQUENTIAL DAMAGES, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF THE USE OR INABILITY TO USE THE FONT SOFTWARE OR FROM OTHER DEALINGS IN THE FONT SOFTWARE. Except as contained in this notice, the names of Gnome, the Gnome Foundation, and Bitstream Inc., shall not be used in advertising or otherwise to promote the sale, use or other dealings in this Font Software without prior written authorization from the Gnome Foundation or Bitstream Inc., respectively. For further information, contact: fonts at gnome dot org. Arev Fonts Copyright ------------------------------ Copyright (c) 2006 by Tavmjong Bah. All Rights Reserved. Permission is hereby granted, free of charge, to any person obtaining a copy of the fonts accompanying this license ("Fonts") and associated documentation files (the "Font Software"), to reproduce and distribute the modifications to the Bitstream Vera Font Software, including without limitation the rights to use, copy, merge, publish, distribute, and/or sell copies of the Font Software, and to permit persons to whom the Font Software is furnished to do so, subject to the following conditions: The above copyright and trademark notices and this permission notice shall be included in all copies of one or more of the Font Software typefaces. The Font Software may be modified, altered, or added to, and in particular the designs of glyphs or characters in the Fonts may be modified and additional glyphs or characters may be added to the Fonts, only if the fonts are renamed to names not containing either the words "Tavmjong Bah" or the word "Arev". This License becomes null and void to the extent applicable to Fonts or Font Software that has been modified and is distributed under the "Tavmjong Bah Arev" names. The Font Software may be sold as part of a larger software package but no copy of one or more of the Font Software typefaces may be sold by itself. THE FONT SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT OF COPYRIGHT, PATENT, TRADEMARK, OR OTHER RIGHT. IN NO EVENT SHALL TAVMJONG BAH BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, INCLUDING ANY GENERAL, SPECIAL, INDIRECT, INCIDENTAL, OR CONSEQUENTIAL DAMAGES, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF THE USE OR INABILITY TO USE THE FONT SOFTWARE OR FROM OTHER DEALINGS IN THE FONT SOFTWARE. Except as contained in this notice, the name of Tavmjong Bah shall not be used in advertising or otherwise to promote the sale, use or other dealings in this Font Software without prior written authorization from Tavmjong Bah. For further information, contact: tavmjong @ free . fr.Fonts are (c) Bitstream (see below). DejaVu changes are in public domain. Glyphs imported from Arev fonts are (c) Tavmjung Bah (see below) Bitstream Vera Fonts Copyright ------------------------------ Copyright (c) 2003 by Bitstream, Inc. All Rights Reserved. Bitstream Vera is a trademark of Bitstream, Inc. Permission is hereby granted, free of charge, to any person obtaining a copy of the fonts accompanying this license ("Fonts") and associated documentation files (the "Font Software"), to reproduce and distribute the Font Software, including without limitation the rights to use, copy, merge, publish, distribute, and/or sell copies of the Font Software, and to permit persons to whom the Font Software is furnished to do so, subject to the following conditions: The above copyright and trademark notices and this permission notice shall be included in all copies of one or more of the Font Software typefaces. The Font Software may be modified, altered, or added to, and in particular the designs of glyphs or characters in the Fonts may be modified and additional glyphs or characters may be added to the Fonts, only if the fonts are renamed to names not containing either the words "Bitstream" or the word "Vera". This License becomes null and void to the extent applicable to Fonts or Font Software that has been modified and is distributed under the "Bitstream Vera" names. The Font Software may be sold as part of a larger software package but no copy of one or more of the Font Software typefaces may be sold by itself. THE FONT SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT OF COPYRIGHT, PATENT, TRADEMARK, OR OTHER RIGHT. IN NO EVENT SHALL BITSTREAM OR THE GNOME FOUNDATION BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, INCLUDING ANY GENERAL, SPECIAL, INDIRECT, INCIDENTAL, OR CONSEQUENTIAL DAMAGES, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF THE USE OR INABILITY TO USE THE FONT SOFTWARE OR FROM OTHER DEALINGS IN THE FONT SOFTWARE. Except as contained in this notice, the names of Gnome, the Gnome Foundation, and Bitstream Inc., shall not be used in advertising or otherwise to promote the sale, use or other dealings in this Font Software without prior written authorization from the Gnome Foundation or Bitstream Inc., respectively. For further information, contact: fonts at gnome dot org. Arev Fonts Copyright ------------------------------ Copyright (c) 2006 by Tavmjong Bah. All Rights Reserved. Permission is hereby granted, free of charge, to any person obtaining a copy of the fonts accompanying this license ("Fonts") and associated documentation files (the "Font Software"), to reproduce and distribute the modifications to the Bitstream Vera Font Software, including without limitation the rights to use, copy, merge, publish, distribute, and/or sell copies of the Font Software, and to permit persons to whom the Font Software is furnished to do so, subject to the following conditions: The above copyright and trademark notices and this permission notice shall be included in all copies of one or more of the Font Software typefaces. The Font Software may be modified, altered, or added to, and in particular the designs of glyphs or characters in the Fonts may be modified and additional glyphs or characters may be added to the Fonts, only if the fonts are renamed to names not containing either the words "Tavmjong Bah" or the word "Arev". This License becomes null and void to the extent applicable to Fonts or Font Software that has been modified and is distributed under the "Tavmjong Bah Arev" names. The Font Software may be sold as part of a larger software package but no copy of one or more of the Font Software typefaces may be sold by itself. THE FONT SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT OF COPYRIGHT, PATENT, TRADEMARK, OR OTHER RIGHT. IN NO EVENT SHALL TAVMJONG BAH BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, INCLUDING ANY GENERAL, SPECIAL, INDIRECT, INCIDENTAL, OR CONSEQUENTIAL DAMAGES, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF THE USE OR INABILITY TO USE THE FONT SOFTWARE OR FROM OTHER DEALINGS IN THE FONT SOFTWARE. Except as contained in this notice, the name of Tavmjong Bah shall not be used in advertising or otherwise to promote the sale, use or other dealings in this Font Software without prior written authorization from Tavmjong Bah. For further information, contact: tavmjong @ free . fr.http://dejavu.sourceforge.net/wiki/index.php/Licensehttps://dejavu.sourceforge.net/wiki/index.php/LicenseDejaVu SansDejaVu SansBookBook~Z  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghjikmlnoqprsutvwxzy{}|~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~                           ! 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All Rights Reserved. DejaVu changes are in public domain Copyright (c) 2003 by Bitstream, Inc. All Rights Reserved. DejaVu changes are in public domain DejaVu SerifDejaVu SerifBoldBoldDejaVu Serif BoldDejaVu Serif BoldDejaVu Serif BoldDejaVu Serif BoldVersion 2.32Version 2.32DejaVuSerif-BoldDejaVuSerif-BoldDejaVu fonts teamDejaVu fonts teamhttp://dejavu.sourceforge.nethttps://dejavu.sourceforge.netFonts are (c) Bitstream (see below). DejaVu changes are in public domain. Bitstream Vera Fonts Copyright ------------------------------ Copyright (c) 2003 by Bitstream, Inc. All Rights Reserved. Bitstream Vera is a trademark of Bitstream, Inc. Permission is hereby granted, free of charge, to any person obtaining a copy of the fonts accompanying this license ("Fonts") and associated documentation files (the "Font Software"), to reproduce and distribute the Font Software, including without limitation the rights to use, copy, merge, publish, distribute, and/or sell copies of the Font Software, and to permit persons to whom the Font Software is furnished to do so, subject to the following conditions: The above copyright and trademark notices and this permission notice shall be included in all copies of one or more of the Font Software typefaces. The Font Software may be modified, altered, or added to, and in particular the designs of glyphs or characters in the Fonts may be modified and additional glyphs or or characters may be added to the Fonts, only if the fonts are renamed to names not containing either the words "Bitstream" or the word "Vera". This License becomes null and void to the extent applicable to Fonts or Font Software that has been modified and is distributed under the "Bitstream Vera" names. The Font Software may be sold as part of a larger software package but no copy of one or more of the Font Software typefaces may be sold by itself. THE FONT SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT OF COPYRIGHT, PATENT, TRADEMARK, OR OTHER RIGHT. IN NO EVENT SHALL BITSTREAM OR THE GNOME FOUNDATION BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, INCLUDING ANY GENERAL, SPECIAL, INDIRECT, INCIDENTAL, OR CONSEQUENTIAL DAMAGES, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF THE USE OR INABILITY TO USE THE FONT SOFTWARE OR FROM OTHER DEALINGS IN THE FONT SOFTWARE. Except as contained in this notice, the names of Gnome, the Gnome Foundation, and Bitstream Inc., shall not be used in advertising or otherwise to promote the sale, use or other dealings in this Font Software without prior written authorization from the Gnome Foundation or Bitstream Inc., respectively. For further information, contact: fonts at gnome dot org. Fonts are (c) Bitstream (see below). DejaVu changes are in public domain. Bitstream Vera Fonts Copyright ------------------------------ Copyright (c) 2003 by Bitstream, Inc. All Rights Reserved. Bitstream Vera is a trademark of Bitstream, Inc. Permission is hereby granted, free of charge, to any person obtaining a copy of the fonts accompanying this license ("Fonts") and associated documentation files (the "Font Software"), to reproduce and distribute the Font Software, including without limitation the rights to use, copy, merge, publish, distribute, and/or sell copies of the Font Software, and to permit persons to whom the Font Software is furnished to do so, subject to the following conditions: The above copyright and trademark notices and this permission notice shall be included in all copies of one or more of the Font Software typefaces. The Font Software may be modified, altered, or added to, and in particular the designs of glyphs or characters in the Fonts may be modified and additional glyphs or or characters may be added to the Fonts, only if the fonts are renamed to names not containing either the words "Bitstream" or the word "Vera". This License becomes null and void to the extent applicable to Fonts or Font Software that has been modified and is distributed under the "Bitstream Vera" names. The Font Software may be sold as part of a larger software package but no copy of one or more of the Font Software typefaces may be sold by itself. THE FONT SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT OF COPYRIGHT, PATENT, TRADEMARK, OR OTHER RIGHT. IN NO EVENT SHALL BITSTREAM OR THE GNOME FOUNDATION BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, INCLUDING ANY GENERAL, SPECIAL, INDIRECT, INCIDENTAL, OR CONSEQUENTIAL DAMAGES, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF THE USE OR INABILITY TO USE THE FONT SOFTWARE OR FROM OTHER DEALINGS IN THE FONT SOFTWARE. Except as contained in this notice, the names of Gnome, the Gnome Foundation, and Bitstream Inc., shall not be used in advertising or otherwise to promote the sale, use or other dealings in this Font Software without prior written authorization from the Gnome Foundation or Bitstream Inc., respectively. For further information, contact: fonts at gnome dot org. http://dejavu.sourceforge.net/wiki/index.php/Licensehttps://dejavu.sourceforge.net/wiki/index.php/LicenseDejaVu SerifDejaVu SerifBoldBold~Z '  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghjikmlnoqprsutvwxzy{}|~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~                           ! 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?X?t???@ @0@L@l@@A0ALAABB,BXBBBBBC$C\CCDDHDDEE$EHElEEEEFF@FdFFFFG G4G\GGGH H8H`HHHII0I`IIIJJ4J\JJJKK(KTKKKKL(LPLLLMMPMMMN(N`NNOO4OhOOOPPDPlPPPQ QLQxQQRR8RdRRRS(SlSSTTDTtTTUUXUUV@VtVVWW0WLWWWWWXX4XPXlXXXYYY4YPYlYYYYYZZ0ZLZhZZZZ[\t]]0]D]`]t]]]]]^^ ^<^X^^^_H_`alacccddDd`dddde$e@eheeeeff@f\ffffgg4g`g|gggh@hiiljdkkllhlmmtmn,nTn|no0oopp0p\ppqq0qLqdq|qqrrDrlrrs sHsst4tttu4uv4vvww,wXwtwwwxz@{{|X}t~0~$`(p,\0|<TxH88h(@   4Pd 0Lp 0Lp$Pt0Lp@d @\ L0\0Lp@d @\ L0\@d @dP<p@lD0Lp@d @\ L0\@d @dP<p@lD@d @dP<p@lD$P|DP@lD4p,p`0\4x<x@|¸Ìh$XŨ<ƀdǰPȠ`@ʰ<ˬt<ͬLΐp tLѨҌhhԸո4d֔(X׌׼L|ج <lٜ0dڔ4p۬$X܈ܸ$\ݨx|hHX(P|08h,`L Lx0` (Pp$T|H(x|l,4$|Xl(dhL$`  L  <   ( T     , X    <l(<<LH$<@40 X!d"#%<&( ) *\+T,p-X./h0|2H3D5 68@9:<;<=>>?\?l?@t@@AB<BCDDDF(F(F(F(F(F(F(F(F(F(F(F(F(F(F(F(F(F(F(F(F(FFFGGG$G4GDGTGdGtGGGGGGGGHHH$H4HDHTHdHtHHHHHHHHIII$I4IDITIdItIIIIIIIIJJJ$J4JDJTJdJtJJJJJJJJKKK$K4KDKTKdKtKKKKKKKKLLL$L4LDLTLdLtLLLLLLLLMMM$M4MDMTMdMtMMMMMMNLNhNNOODOxOOPP<PTPPQ$Q<QTRTRSpT|UtUVWW8WTWpWWWWWXX4XPXlXXXXXYY0YLYhYZH  +@ >_ :U !X  4 9 T     G &\ &  $ "4 :j & h    FCopyright (c) 2003 by Bitstream, Inc. All Rights Reserved. DejaVu changes are in public domain Copyright (c) 2003 by Bitstream, Inc. All Rights Reserved. DejaVu changes are in public domain DejaVu SerifDejaVu SerifItalicItalicDejaVu Serif ItalicDejaVu Serif ItalicDejaVu Serif ItalicDejaVu Serif ItalicVersion 2.32Version 2.32DejaVuSerif-ItalicDejaVuSerif-ItalicDejaVu fonts teamDejaVu fonts teamhttp://dejavu.sourceforge.nethttps://dejavu.sourceforge.netFonts are (c) Bitstream (see below). DejaVu changes are in public domain. Bitstream Vera Fonts Copyright ------------------------------ Copyright (c) 2003 by Bitstream, Inc. All Rights Reserved. Bitstream Vera is a trademark of Bitstream, Inc. Permission is hereby granted, free of charge, to any person obtaining a copy of the fonts accompanying this license ("Fonts") and associated documentation files (the "Font Software"), to reproduce and distribute the Font Software, including without limitation the rights to use, copy, merge, publish, distribute, and/or sell copies of the Font Software, and to permit persons to whom the Font Software is furnished to do so, subject to the following conditions: The above copyright and trademark notices and this permission notice shall be included in all copies of one or more of the Font Software typefaces. The Font Software may be modified, altered, or added to, and in particular the designs of glyphs or characters in the Fonts may be modified and additional glyphs or or characters may be added to the Fonts, only if the fonts are renamed to names not containing either the words "Bitstream" or the word "Vera". This License becomes null and void to the extent applicable to Fonts or Font Software that has been modified and is distributed under the "Bitstream Vera" names. The Font Software may be sold as part of a larger software package but no copy of one or more of the Font Software typefaces may be sold by itself. THE FONT SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT OF COPYRIGHT, PATENT, TRADEMARK, OR OTHER RIGHT. IN NO EVENT SHALL BITSTREAM OR THE GNOME FOUNDATION BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, INCLUDING ANY GENERAL, SPECIAL, INDIRECT, INCIDENTAL, OR CONSEQUENTIAL DAMAGES, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF THE USE OR INABILITY TO USE THE FONT SOFTWARE OR FROM OTHER DEALINGS IN THE FONT SOFTWARE. Except as contained in this notice, the names of Gnome, the Gnome Foundation, and Bitstream Inc., shall not be used in advertising or otherwise to promote the sale, use or other dealings in this Font Software without prior written authorization from the Gnome Foundation or Bitstream Inc., respectively. For further information, contact: fonts at gnome dot org. Fonts are (c) Bitstream (see below). DejaVu changes are in public domain. Bitstream Vera Fonts Copyright ------------------------------ Copyright (c) 2003 by Bitstream, Inc. All Rights Reserved. Bitstream Vera is a trademark of Bitstream, Inc. Permission is hereby granted, free of charge, to any person obtaining a copy of the fonts accompanying this license ("Fonts") and associated documentation files (the "Font Software"), to reproduce and distribute the Font Software, including without limitation the rights to use, copy, merge, publish, distribute, and/or sell copies of the Font Software, and to permit persons to whom the Font Software is furnished to do so, subject to the following conditions: The above copyright and trademark notices and this permission notice shall be included in all copies of one or more of the Font Software typefaces. The Font Software may be modified, altered, or added to, and in particular the designs of glyphs or characters in the Fonts may be modified and additional glyphs or or characters may be added to the Fonts, only if the fonts are renamed to names not containing either the words "Bitstream" or the word "Vera". This License becomes null and void to the extent applicable to Fonts or Font Software that has been modified and is distributed under the "Bitstream Vera" names. The Font Software may be sold as part of a larger software package but no copy of one or more of the Font Software typefaces may be sold by itself. THE FONT SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT OF COPYRIGHT, PATENT, TRADEMARK, OR OTHER RIGHT. IN NO EVENT SHALL BITSTREAM OR THE GNOME FOUNDATION BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, INCLUDING ANY GENERAL, SPECIAL, INDIRECT, INCIDENTAL, OR CONSEQUENTIAL DAMAGES, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF THE USE OR INABILITY TO USE THE FONT SOFTWARE OR FROM OTHER DEALINGS IN THE FONT SOFTWARE. Except as contained in this notice, the names of Gnome, the Gnome Foundation, and Bitstream Inc., shall not be used in advertising or otherwise to promote the sale, use or other dealings in this Font Software without prior written authorization from the Gnome Foundation or Bitstream Inc., respectively. For further information, contact: fonts at gnome dot org. http://dejavu.sourceforge.net/wiki/index.php/Licensehttps://dejavu.sourceforge.net/wiki/index.php/LicenseDejaVu SerifDejaVu SerifItalicItalic~Z   !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghjikmlnoqprsutvwxzy{}|~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~                           ! 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Bu xd xu xd xd xu xd xd xu xd xu xu@@,@,@,@,@,@,@,@@,@,@,@,@,@,@,@@,@,@,@,@,@,@,@@,@,@,@,@,@,@,@@,@,@,@,@,@,@,@@,@,@,@,@,@,@,@@,@,@,@,@,@,@,@@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@@,@,@,@,@,@,@,@@,@,@,@,@,@,@,@@,@,@,@,@,@,@,@@,@,@,@,@,@,@,@@,@,@,@,@,@,@,@@,@,@,@,@,@,@,@@,@,@,@,@,@,@,@@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,@,du__::: J776676uuMM''''$$"pMM   )fB3R\\b1 c: =sH7NBNXx\qffiishc1 1 wwjff,O`qwP9w9Wqfffff+'fw1 wff,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,5| >t b` d8( dq[{es^Lq fXLfX @fX: Lu w3v3vLLLRsRs@ tnxj jX F X oX `X `XH `XDeXVvS@xX! @fX! 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All Rights Reserved. Copyright (c) 2006 by Tavmjong Bah. All Rights Reserved. DejaVu changes are in public domain Copyright (c) 2003 by Bitstream, Inc. All Rights Reserved. Copyright (c) 2006 by Tavmjong Bah. All Rights Reserved. DejaVu changes are in public domain DejaVu SansDejaVu SansBoldBoldDejaVu Sans BoldDejaVu Sans BoldDejaVu Sans BoldDejaVu Sans BoldVersion 2.32Version 2.32DejaVuSans-BoldDejaVuSans-BoldDejaVu fonts teamDejaVu fonts teamhttp://dejavu.sourceforge.nethttps://dejavu.sourceforge.netFonts are (c) Bitstream (see below). DejaVu changes are in public domain. Glyphs imported from Arev fonts are (c) Tavmjung Bah (see below) Bitstream Vera Fonts Copyright ------------------------------ Copyright (c) 2003 by Bitstream, Inc. All Rights Reserved. Bitstream Vera is a trademark of Bitstream, Inc. Permission is hereby granted, free of charge, to any person obtaining a copy of the fonts accompanying this license ("Fonts") and associated documentation files (the "Font Software"), to reproduce and distribute the Font Software, including without limitation the rights to use, copy, merge, publish, distribute, and/or sell copies of the Font Software, and to permit persons to whom the Font Software is furnished to do so, subject to the following conditions: The above copyright and trademark notices and this permission notice shall be included in all copies of one or more of the Font Software typefaces. The Font Software may be modified, altered, or added to, and in particular the designs of glyphs or characters in the Fonts may be modified and additional glyphs or characters may be added to the Fonts, only if the fonts are renamed to names not containing either the words "Bitstream" or the word "Vera". This License becomes null and void to the extent applicable to Fonts or Font Software that has been modified and is distributed under the "Bitstream Vera" names. The Font Software may be sold as part of a larger software package but no copy of one or more of the Font Software typefaces may be sold by itself. THE FONT SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT OF COPYRIGHT, PATENT, TRADEMARK, OR OTHER RIGHT. IN NO EVENT SHALL BITSTREAM OR THE GNOME FOUNDATION BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, INCLUDING ANY GENERAL, SPECIAL, INDIRECT, INCIDENTAL, OR CONSEQUENTIAL DAMAGES, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF THE USE OR INABILITY TO USE THE FONT SOFTWARE OR FROM OTHER DEALINGS IN THE FONT SOFTWARE. Except as contained in this notice, the names of Gnome, the Gnome Foundation, and Bitstream Inc., shall not be used in advertising or otherwise to promote the sale, use or other dealings in this Font Software without prior written authorization from the Gnome Foundation or Bitstream Inc., respectively. For further information, contact: fonts at gnome dot org. Arev Fonts Copyright ------------------------------ Copyright (c) 2006 by Tavmjong Bah. All Rights Reserved. Permission is hereby granted, free of charge, to any person obtaining a copy of the fonts accompanying this license ("Fonts") and associated documentation files (the "Font Software"), to reproduce and distribute the modifications to the Bitstream Vera Font Software, including without limitation the rights to use, copy, merge, publish, distribute, and/or sell copies of the Font Software, and to permit persons to whom the Font Software is furnished to do so, subject to the following conditions: The above copyright and trademark notices and this permission notice shall be included in all copies of one or more of the Font Software typefaces. The Font Software may be modified, altered, or added to, and in particular the designs of glyphs or characters in the Fonts may be modified and additional glyphs or characters may be added to the Fonts, only if the fonts are renamed to names not containing either the words "Tavmjong Bah" or the word "Arev". This License becomes null and void to the extent applicable to Fonts or Font Software that has been modified and is distributed under the "Tavmjong Bah Arev" names. The Font Software may be sold as part of a larger software package but no copy of one or more of the Font Software typefaces may be sold by itself. THE FONT SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT OF COPYRIGHT, PATENT, TRADEMARK, OR OTHER RIGHT. IN NO EVENT SHALL TAVMJONG BAH BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, INCLUDING ANY GENERAL, SPECIAL, INDIRECT, INCIDENTAL, OR CONSEQUENTIAL DAMAGES, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF THE USE OR INABILITY TO USE THE FONT SOFTWARE OR FROM OTHER DEALINGS IN THE FONT SOFTWARE. Except as contained in this notice, the name of Tavmjong Bah shall not be used in advertising or otherwise to promote the sale, use or other dealings in this Font Software without prior written authorization from Tavmjong Bah. For further information, contact: tavmjong @ free . fr.Fonts are (c) Bitstream (see below). DejaVu changes are in public domain. Glyphs imported from Arev fonts are (c) Tavmjung Bah (see below) Bitstream Vera Fonts Copyright ------------------------------ Copyright (c) 2003 by Bitstream, Inc. All Rights Reserved. Bitstream Vera is a trademark of Bitstream, Inc. Permission is hereby granted, free of charge, to any person obtaining a copy of the fonts accompanying this license ("Fonts") and associated documentation files (the "Font Software"), to reproduce and distribute the Font Software, including without limitation the rights to use, copy, merge, publish, distribute, and/or sell copies of the Font Software, and to permit persons to whom the Font Software is furnished to do so, subject to the following conditions: The above copyright and trademark notices and this permission notice shall be included in all copies of one or more of the Font Software typefaces. The Font Software may be modified, altered, or added to, and in particular the designs of glyphs or characters in the Fonts may be modified and additional glyphs or characters may be added to the Fonts, only if the fonts are renamed to names not containing either the words "Bitstream" or the word "Vera". This License becomes null and void to the extent applicable to Fonts or Font Software that has been modified and is distributed under the "Bitstream Vera" names. The Font Software may be sold as part of a larger software package but no copy of one or more of the Font Software typefaces may be sold by itself. THE FONT SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT OF COPYRIGHT, PATENT, TRADEMARK, OR OTHER RIGHT. IN NO EVENT SHALL BITSTREAM OR THE GNOME FOUNDATION BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, INCLUDING ANY GENERAL, SPECIAL, INDIRECT, INCIDENTAL, OR CONSEQUENTIAL DAMAGES, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF THE USE OR INABILITY TO USE THE FONT SOFTWARE OR FROM OTHER DEALINGS IN THE FONT SOFTWARE. Except as contained in this notice, the names of Gnome, the Gnome Foundation, and Bitstream Inc., shall not be used in advertising or otherwise to promote the sale, use or other dealings in this Font Software without prior written authorization from the Gnome Foundation or Bitstream Inc., respectively. For further information, contact: fonts at gnome dot org. Arev Fonts Copyright ------------------------------ Copyright (c) 2006 by Tavmjong Bah. All Rights Reserved. Permission is hereby granted, free of charge, to any person obtaining a copy of the fonts accompanying this license ("Fonts") and associated documentation files (the "Font Software"), to reproduce and distribute the modifications to the Bitstream Vera Font Software, including without limitation the rights to use, copy, merge, publish, distribute, and/or sell copies of the Font Software, and to permit persons to whom the Font Software is furnished to do so, subject to the following conditions: The above copyright and trademark notices and this permission notice shall be included in all copies of one or more of the Font Software typefaces. The Font Software may be modified, altered, or added to, and in particular the designs of glyphs or characters in the Fonts may be modified and additional glyphs or characters may be added to the Fonts, only if the fonts are renamed to names not containing either the words "Tavmjong Bah" or the word "Arev". This License becomes null and void to the extent applicable to Fonts or Font Software that has been modified and is distributed under the "Tavmjong Bah Arev" names. The Font Software may be sold as part of a larger software package but no copy of one or more of the Font Software typefaces may be sold by itself. THE FONT SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT OF COPYRIGHT, PATENT, TRADEMARK, OR OTHER RIGHT. IN NO EVENT SHALL TAVMJONG BAH BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, INCLUDING ANY GENERAL, SPECIAL, INDIRECT, INCIDENTAL, OR CONSEQUENTIAL DAMAGES, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF THE USE OR INABILITY TO USE THE FONT SOFTWARE OR FROM OTHER DEALINGS IN THE FONT SOFTWARE. Except as contained in this notice, the name of Tavmjong Bah shall not be used in advertising or otherwise to promote the sale, use or other dealings in this Font Software without prior written authorization from Tavmjong Bah. For further information, contact: tavmjong @ free . fr.http://dejavu.sourceforge.net/wiki/index.php/Licensehttps://dejavu.sourceforge.net/wiki/index.php/LicenseDejaVu SansDejaVu SansBoldBold~Z:  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghjikmlnoqprsutvwxzy{}|~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~                           ! 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arrowdblbothuni21D5uni21D6uni21D7uni21D8uni21D9uni21DAuni21DBuni21DCuni21DDuni21DEuni21DFuni21E0uni21E1uni21E2uni21E3uni21E4uni21E5uni21E6uni21E7uni21E8uni21E9uni21EAuni21EBuni21ECuni21EDuni21EEuni21EFuni21F0uni21F1uni21F2uni21F3uni21F4uni21F5uni21F6uni21F7uni21F8uni21F9uni21FAuni21FBuni21FCuni21FDuni21FEuni21FF universaluni2201 existentialuni2204emptysetgradientelement notelementuni220Asuchthatuni220Cuni220Duni220Euni2210uni2213uni2214uni2215uni2216 asteriskmathuni2218uni2219uni221Buni221C proportional orthogonalangleuni2221uni2222uni2223uni2224uni2225uni2226 logicaland logicalor intersectionunionuni222Cuni222Duni222Euni222Funi2230uni2231uni2232uni2233 thereforeuni2235uni2236uni2237uni2238uni2239uni223Auni223Bsimilaruni223Duni223Euni223Funi2240uni2241uni2242uni2243uni2244 congruentuni2246uni2247uni2249uni224Auni224Buni224Cuni224Duni224Euni224Funi2250uni2251uni2252uni2253uni2254uni2255uni2256uni2257uni2258uni2259uni225Auni225Buni225Cuni225Duni225Euni225F equivalenceuni2262uni2263uni2266uni2267uni2268uni2269uni226Auni226Buni226Cuni226Duni226Euni226Funi2270uni2271uni2272uni2273uni2274uni2275uni2276uni2277uni2278uni2279uni227Auni227Buni227Cuni227Duni227Euni227Funi2280uni2281 propersubsetpropersuperset notsubsetuni2285 reflexsubsetreflexsupersetuni2288uni2289uni228Auni228Buni228Cuni228Duni228Euni228Funi2290uni2291uni2292uni2293uni2294 circleplusuni2296circlemultiplyuni2298uni2299uni229Auni229Buni229Cuni229Duni229Euni229Funi22A0uni22A1uni22A2uni22A3uni22A4 perpendicularuni22A6uni22A7uni22A8uni22A9uni22AAuni22ABuni22ACuni22ADuni22AEuni22AFuni22B0uni22B1uni22B2uni22B3uni22B4uni22B5uni22B6uni22B7uni22B8uni22B9uni22BAuni22BBuni22BCuni22BDuni22BEuni22BFuni22C0uni22C1uni22C2uni22C3uni22C4dotmathuni22C6uni22C7uni22C8uni22C9uni22CAuni22CBuni22CCuni22CDuni22CEuni22CFuni22D0uni22D1uni22D2uni22D3uni22D4uni22D5uni22D6uni22D7uni22D8uni22D9uni22DAuni22DBuni22DCuni22DDuni22DEuni22DFuni22E0uni22E1uni22E2uni22E3uni22E4uni22E5uni22E6uni22E7uni22E8uni22E9uni22EAuni22EBuni22ECuni22EDuni22EEuni22EFuni22F0uni22F1uni22F2uni22F3uni22F4uni22F5uni22F6uni22F7uni22F8uni22F9uni22FAuni22FBuni22FCuni22FDuni22FEuni22FFuni2300uni2301houseuni2303uni2304uni2305uni2306uni2307uni2308uni2309uni230Auni230Buni230Cuni230Duni230Euni230F revlogicalnotuni2311uni2318uni2319uni231Cuni231Duni231Euni231F integraltp integralbtuni2324uni2325uni2326uni2327uni2328uni232Buni232Cuni2373uni2374uni2375uni237Auni237Duni2387uni2394uni239Buni239Cuni239Duni239Euni239Funi23A0uni23A1uni23A2uni23A3uni23A4uni23A5uni23A6uni23A7uni23A8uni23A9uni23AAuni23ABuni23ACuni23ADuni23AEuni23CEuni23CFuni23E3uni23E5uni23E8uni2422uni2423uni2460uni2461uni2462uni2463uni2464uni2465uni2466uni2467uni2468uni2469upblockuni2581uni2582uni2583dnblockuni2585uni2586uni2587blockuni2589uni258Auni258Blfblockuni258Duni258Euni258Frtblockltshadeshadedkshadeuni2594uni2595uni2596uni2597uni2598uni2599uni259Auni259Buni259Cuni259Duni259Euni259F filledboxH22073uni25A2uni25A3uni25A4uni25A5uni25A6uni25A7uni25A8uni25A9H18543H18551 filledrectuni25ADuni25AEuni25AFuni25B0uni25B1triagupuni25B3uni25B4uni25B5uni25B6uni25B7uni25B8uni25B9triagrtuni25BBtriagdnuni25BDuni25BEuni25BFuni25C0uni25C1uni25C2uni25C3triaglfuni25C5uni25C6uni25C7uni25C8uni25C9circleuni25CCuni25CDuni25CEH18533uni25D0uni25D1uni25D2uni25D3uni25D4uni25D5uni25D6uni25D7 invbullet invcircleuni25DAuni25DBuni25DCuni25DDuni25DEuni25DFuni25E0uni25E1uni25E2uni25E3uni25E4uni25E5 openbulletuni25E7uni25E8uni25E9uni25EAuni25EBuni25ECuni25EDuni25EEuni25EFuni25F0uni25F1uni25F2uni25F3uni25F4uni25F5uni25F6uni25F7uni25F8uni25F9uni25FAuni25FBuni25FCuni25FDuni25FEuni25FFuni2600uni2601uni2602uni2603uni2604uni2605uni2606uni2607uni2608uni2609uni260Auni260Buni260Cuni260Duni260Euni260Funi2610uni2611uni2612uni2613uni2614uni2615uni2616uni2617uni2618uni2619uni261Auni261Buni261Cuni261Duni261Euni261Funi2620uni2621uni2622uni2623uni2624uni2625uni2626uni2627uni2628uni2629uni262Auni262Buni262Cuni262Duni262Euni262Funi2630uni2631uni2632uni2633uni2634uni2635uni2636uni2637uni2638uni2639 smileface invsmilefacesununi263Duni263Euni263Ffemaleuni2641maleuni2643uni2644uni2645uni2646uni2647uni2648uni2649uni264Auni264Buni264Cuni264Duni264Euni264Funi2650uni2651uni2652uni2653uni2654uni2655uni2656uni2657uni2658uni2659uni265Auni265Buni265Cuni265Duni265Euni265Fspadeuni2661uni2662clubuni2664heartdiamonduni2667uni2668uni2669 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130 0 R 132 0 R 134 0 R 136 0 R 138 0 R 140 0 R 142 0 R 144 0 R 146 0 R 148 0 R 150 0 R 152 0 R 154 0 R 156 0 R 158 0 R 160 0 R 162 0 R 164 0 R 166 0 R 168 0 R 170 0 R 172 0 R 174 0 R 176 0 R 178 0 R 180 0 R 182 0 R 184 0 R 186 0 R 188 0 R 190 0 R 192 0 R 194 0 R 196 0 R 198 0 R 200 0 R 202 0 R 204 0 R 206 0 R 208 0 R 210 0 R 212 0 R 214 0 R 216 0 R 218 0 R 220 0 R 222 0 R 224 0 R 226 0 R 228 0 R 230 0 R 232 0 R 234 0 R 236 0 R 238 0 R 240 0 R 242 0 R ] /Contents 93 0 R >> endobj 93 0 obj << /Length 36004 >> stream 0.271 0.267 0.267 rg q 15.000 42.732 577.500 734.268 re W n 0.271 0.267 0.267 rg BT 26.250 764.645 Td /F1 9.8 Tf [(presentation; the dominant motor feature being a parkinsonian type syndrome of rigidity, dystonia and )] TJ ET BT 26.250 749.201 Td /F1 9.8 Tf [(bradykinesia, rather than chorea)] TJ ET 0.267 0.267 0.267 rg BT 186.735 751.156 Td /F4 8.7 Tf [(2)] TJ ET BT 192.767 751.156 Td /F4 8.7 Tf [(3)] TJ ET BT 198.799 751.156 Td /F4 8.7 Tf [(4)] TJ ET 0.271 0.267 0.267 rg BT 204.831 749.201 Td /F1 9.8 Tf [( . In addition, childhood cases may also present with cerebellar signs, )] TJ ET BT 26.250 733.757 Td /F1 9.8 Tf [(epilepsy, myoclonus and spasticity)] TJ ET 0.267 0.267 0.267 rg BT 196.894 735.712 Td /F4 8.7 Tf [(5)] TJ ET BT 202.927 735.712 Td /F4 8.7 Tf [(6)] TJ ET 0.271 0.267 0.267 rg BT 208.959 733.757 Td /F1 9.8 Tf [( . Behavioural problems and cognitive decline are also common in JHD)] TJ ET 0.267 0.267 0.267 rg BT 552.977 735.712 Td /F4 8.7 Tf [(4)] TJ ET BT 559.010 735.712 Td /F4 8.7 Tf [(6)] TJ ET 0.271 0.267 0.267 rg BT 565.042 733.757 Td /F1 9.8 Tf [( , )] TJ ET BT 26.250 718.313 Td /F1 9.8 Tf [(with additional features of developmental delay and autism in childhood cases)] TJ ET 0.267 0.267 0.267 rg BT 411.394 720.268 Td /F4 8.7 Tf [(5)] TJ ET 0.271 0.267 0.267 rg BT 417.427 718.313 Td /F1 9.8 Tf [( .)] TJ ET BT 26.250 695.369 Td /F1 9.8 Tf [(The causative mutation in HD has been identified as an expanded CAG repeat sequence in the first exon of the )] TJ ET BT 26.250 679.925 Td /F1 9.8 Tf [(HTT gene )] TJ ET 0.267 0.267 0.267 rg BT 76.063 681.880 Td /F4 8.7 Tf [(7)] TJ ET 0.271 0.267 0.267 rg BT 82.095 679.925 Td /F1 9.8 Tf [( . A CAG repeat of ? 40 is unequivocally fully penetrant, with CAG repeats of 36-39 showing reduced )] TJ ET BT 26.250 664.481 Td /F1 9.8 Tf [(penetrance)] TJ ET 0.267 0.267 0.267 rg BT 81.962 666.436 Td /F4 8.7 Tf [(8)] TJ ET 0.271 0.267 0.267 rg BT 87.994 664.481 Td /F1 9.8 Tf [( . JHD is usually associated with a CAG repeat of ? 60 repeats in approximately 50% of cases)] TJ ET 0.267 0.267 0.267 rg BT 540.959 666.436 Td /F4 8.7 Tf [(9)] TJ ET 0.271 0.267 0.267 rg BT 546.991 664.481 Td /F1 9.8 Tf [( , with )] TJ ET BT 26.250 649.037 Td /F1 9.8 Tf [(childhood onset often exhibiting a repeat size of ? 80)] TJ ET 0.267 0.267 0.267 rg BT 286.380 650.992 Td /F4 8.7 Tf [(5)] TJ ET BT 292.412 650.992 Td /F4 8.7 Tf [(10)] TJ ET 0.271 0.267 0.267 rg BT 304.476 649.037 Td /F1 9.8 Tf [( . However, consistent with findings in adult cases,CAG )] TJ ET BT 26.250 633.593 Td /F1 9.8 Tf [(repeat size does not always correlate with age of onset in JHD)] TJ ET 0.267 0.267 0.267 rg BT 329.699 635.548 Td /F4 8.7 Tf [(5)] TJ ET 0.271 0.267 0.267 rg BT 335.731 633.593 Td /F1 9.8 Tf [( .)] TJ ET BT 26.250 610.649 Td /F1 9.8 Tf [(The prevalence of HD is considered to be approximately 4-10 cases per 100,000 in Caucasian populations)] TJ ET 0.267 0.267 0.267 rg BT 545.603 612.604 Td /F4 8.7 Tf [(11)] TJ ET 0.271 0.267 0.267 rg BT 557.667 610.649 Td /F1 9.8 Tf [(but )] TJ ET BT 26.250 595.205 Td /F1 9.8 Tf [(this may be higher)] TJ ET 0.267 0.267 0.267 rg BT 118.046 597.160 Td /F4 8.7 Tf [(15)] TJ ET 0.271 0.267 0.267 rg BT 130.110 595.205 Td /F1 9.8 Tf [( . Such variability may be accounted for in part by differences in methods of )] TJ ET BT 26.250 579.761 Td /F1 9.8 Tf [(ascertainment, prevalence method used \(period or point prevalence\) and diagnostic/age of onset criteria. Low )] TJ ET BT 26.250 564.317 Td /F1 9.8 Tf [(prevalence rates of less than 1 case per 100,000 have been reported in Japanese populations)] TJ ET 0.267 0.267 0.267 rg BT 484.890 566.272 Td /F4 8.7 Tf [(11)] TJ ET BT 496.954 566.272 Td /F4 8.7 Tf [(12)] TJ ET 0.271 0.267 0.267 rg BT 509.018 564.317 Td /F1 9.8 Tf [( . Well )] TJ ET BT 26.250 548.873 Td /F1 9.8 Tf [(developed medical services in Japan mean under-ascertainment is unlikely)] TJ ET 0.267 0.267 0.267 rg BT 392.645 550.828 Td /F4 8.7 Tf [(12)] TJ ET 0.271 0.267 0.267 rg BT 404.709 546.195 Td /F1 8.7 Tf [(.. )] TJ ET BT 412.977 548.873 Td /F1 9.8 Tf [(More recently, Warby et al \(2011\))] TJ ET 0.267 0.267 0.267 rg BT 26.250 535.384 Td /F4 8.7 Tf [(16)] TJ ET 0.271 0.267 0.267 rg BT 38.314 533.429 Td /F1 9.8 Tf [( have summarised prevalence data from around the world and discussed the reasons for low prevalence in )] TJ ET BT 26.250 517.985 Td /F1 9.8 Tf [(some countries. Prevalence in African and American black populations is also considered to be lower than in )] TJ ET BT 26.250 502.541 Td /F1 9.8 Tf [(white populations)] TJ ET 0.267 0.267 0.267 rg BT 113.015 504.496 Td /F4 8.7 Tf [(17)] TJ ET BT 125.079 504.496 Td /F4 8.7 Tf [(18)] TJ ET 0.271 0.267 0.267 rg BT 137.143 502.541 Td /F1 9.8 Tf [( . However this may represent under-ascertainment)] TJ ET 0.267 0.267 0.267 rg BT 390.897 504.496 Td /F4 8.7 Tf [(12)] TJ ET 0.271 0.267 0.267 rg BT 402.961 502.541 Td /F1 9.8 Tf [( , with studies employing more )] TJ ET BT 26.250 487.097 Td /F1 9.8 Tf [(extensive methods reporting equivalent rates)] TJ ET 0.267 0.267 0.267 rg BT 250.208 489.052 Td /F4 8.7 Tf [(19)] TJ ET 0.271 0.267 0.267 rg BT 262.272 487.097 Td /F1 9.8 Tf [( . Juvenile onset HD is considered to be extremely rare, with few )] TJ ET BT 26.250 471.653 Td /F1 9.8 Tf [(clinicians ever seeing more than one case. In 1981, Hayden summarised the prevalence of JHD, expressed as a )] TJ ET BT 26.250 456.209 Td /F1 9.8 Tf [(percentage of the total number of HD cases surveyed)] TJ ET 0.267 0.267 0.267 rg BT 289.256 458.164 Td /F4 8.7 Tf [(11)] TJ ET 0.271 0.267 0.267 rg BT 301.320 456.209 Td /F1 9.8 Tf [( . Presented by country, a mean of 5.7% of HD cases )] TJ ET BT 26.250 440.765 Td /F1 9.8 Tf [(were found to be of juvenile onset, with a range of 1-9.6%. Childhood onset was rarer than adolescent onset, )] TJ ET BT 26.250 425.321 Td /F1 9.8 Tf [(with means of 1.3% and 4.4%, respectively. These findings are consistent with the widely accepted belief that )] TJ ET BT 26.250 409.877 Td /F1 9.8 Tf [(JHD is indeed a rare form of the disease.)] TJ ET BT 26.250 386.933 Td /F1 9.8 Tf [(Although Hayden s work has been the first and only summary of the epidemiology of JHD known to the authors, )] TJ ET BT 26.250 371.489 Td /F1 9.8 Tf [(there are several limitations in combining and interpreting the data in this way to obtain an estimate of the )] TJ ET BT 26.250 356.045 Td /F1 9.8 Tf [(proportion of JHD cases. The first concerns the pooling of data from different types of studies, such as those )] TJ ET BT 26.250 340.601 Td /F1 9.8 Tf [(reporting period with those reporting point prevalence. Secondly, data are included that are published in more )] TJ ET BT 26.250 325.157 Td /F1 9.8 Tf [(than one paper. Furthermore, the Hayden report includes studies which, due to differences in country and year )] TJ ET BT 26.250 309.713 Td /F1 9.8 Tf [(of study, report prevalence in populations with different age-sex structures. This potentially introduces a bias; )] TJ ET BT 26.250 294.269 Td /F1 9.8 Tf [(lower life expectancies artificially raise the proportion of cases with juvenile onset as patients with adult onset )] TJ ET BT 26.250 278.825 Td /F1 9.8 Tf [(are more likely to die prematurely from unrelated causes. The aim of the current study is therefore to update )] TJ ET BT 26.250 263.381 Td /F1 9.8 Tf [(and expand Hayden s work, exploring the impact of study level factors on the estimated proportion of HD cases )] TJ ET BT 26.250 247.937 Td /F1 9.8 Tf [(with juvenile onset.)] TJ ET BT 26.250 207.142 Td /F4 12.0 Tf [(Methods)] TJ ET BT 26.250 183.485 Td /F1 9.8 Tf [(We searched the MEDLINE and EMBASE databases for the period 1981-May 2011. The following search terms )] TJ ET BT 26.250 168.041 Td /F1 9.8 Tf [(were used in the title and abstract field:)] TJ ET BT 26.250 145.097 Td /F1 9.8 Tf [(Huntington s AND disease AND Prevalence)] TJ ET BT 26.250 122.153 Td /F1 9.8 Tf [(Huntington s AND disease AND Population)] TJ ET BT 26.250 99.209 Td /F1 9.8 Tf [(Huntington s AND disease AND Epidemiology*)] TJ ET BT 26.250 76.265 Td /F1 9.8 Tf [(Huntington s AND disease AND Incidence)] TJ ET BT 26.250 53.321 Td /F1 9.8 Tf [(Huntington*AND Prevalence)] TJ ET Q q 15.000 42.732 577.500 734.268 re W n 0.271 0.267 0.267 rg BT 26.250 764.645 Td /F1 9.8 Tf [(presentation; the dominant motor feature being a parkinsonian type syndrome of rigidity, dystonia and )] TJ ET BT 26.250 749.201 Td /F1 9.8 Tf [(bradykinesia, rather than chorea)] TJ ET 0.267 0.267 0.267 rg BT 186.735 751.156 Td /F4 8.7 Tf [(2)] TJ ET BT 192.767 751.156 Td /F4 8.7 Tf [(3)] TJ ET BT 198.799 751.156 Td /F4 8.7 Tf [(4)] TJ ET 0.271 0.267 0.267 rg BT 204.831 749.201 Td /F1 9.8 Tf [( . In addition, childhood cases may also present with cerebellar signs, )] TJ ET BT 26.250 733.757 Td /F1 9.8 Tf [(epilepsy, myoclonus and spasticity)] TJ ET 0.267 0.267 0.267 rg BT 196.894 735.712 Td /F4 8.7 Tf [(5)] TJ ET BT 202.927 735.712 Td /F4 8.7 Tf [(6)] TJ ET 0.271 0.267 0.267 rg BT 208.959 733.757 Td /F1 9.8 Tf [( . Behavioural problems and cognitive decline are also common in JHD)] TJ ET 0.267 0.267 0.267 rg BT 552.977 735.712 Td /F4 8.7 Tf [(4)] TJ ET BT 559.010 735.712 Td /F4 8.7 Tf [(6)] TJ ET 0.271 0.267 0.267 rg BT 565.042 733.757 Td /F1 9.8 Tf [( , )] TJ ET BT 26.250 718.313 Td /F1 9.8 Tf [(with additional features of developmental delay and autism in childhood cases)] TJ ET 0.267 0.267 0.267 rg BT 411.394 720.268 Td /F4 8.7 Tf [(5)] TJ ET 0.271 0.267 0.267 rg BT 417.427 718.313 Td /F1 9.8 Tf [( .)] TJ ET BT 26.250 695.369 Td /F1 9.8 Tf [(The causative mutation in HD has been identified as an expanded CAG repeat sequence in the first exon of the )] TJ ET BT 26.250 679.925 Td /F1 9.8 Tf [(HTT gene )] TJ ET 0.267 0.267 0.267 rg BT 76.063 681.880 Td /F4 8.7 Tf [(7)] TJ ET 0.271 0.267 0.267 rg BT 82.095 679.925 Td /F1 9.8 Tf [( . A CAG repeat of ? 40 is unequivocally fully penetrant, with CAG repeats of 36-39 showing reduced )] TJ ET BT 26.250 664.481 Td /F1 9.8 Tf [(penetrance)] TJ ET 0.267 0.267 0.267 rg BT 81.962 666.436 Td /F4 8.7 Tf [(8)] TJ ET 0.271 0.267 0.267 rg BT 87.994 664.481 Td /F1 9.8 Tf [( . JHD is usually associated with a CAG repeat of ? 60 repeats in approximately 50% of cases)] TJ ET 0.267 0.267 0.267 rg BT 540.959 666.436 Td /F4 8.7 Tf [(9)] TJ ET 0.271 0.267 0.267 rg BT 546.991 664.481 Td /F1 9.8 Tf [( , with )] TJ ET BT 26.250 649.037 Td /F1 9.8 Tf [(childhood onset often exhibiting a repeat size of ? 80)] TJ ET 0.267 0.267 0.267 rg BT 286.380 650.992 Td /F4 8.7 Tf [(5)] TJ ET BT 292.412 650.992 Td /F4 8.7 Tf [(10)] TJ ET 0.271 0.267 0.267 rg BT 304.476 649.037 Td /F1 9.8 Tf [( . However, consistent with findings in adult cases,CAG )] TJ ET BT 26.250 633.593 Td /F1 9.8 Tf [(repeat size does not always correlate with age of onset in JHD)] TJ ET 0.267 0.267 0.267 rg BT 329.699 635.548 Td /F4 8.7 Tf [(5)] TJ ET 0.271 0.267 0.267 rg BT 335.731 633.593 Td /F1 9.8 Tf [( .)] TJ ET BT 26.250 610.649 Td /F1 9.8 Tf [(The prevalence of HD is considered to be approximately 4-10 cases per 100,000 in Caucasian populations)] TJ ET 0.267 0.267 0.267 rg BT 545.603 612.604 Td /F4 8.7 Tf [(11)] TJ ET 0.271 0.267 0.267 rg BT 557.667 610.649 Td /F1 9.8 Tf [(but )] TJ ET BT 26.250 595.205 Td /F1 9.8 Tf [(this may be higher)] TJ ET 0.267 0.267 0.267 rg BT 118.046 597.160 Td /F4 8.7 Tf [(15)] TJ ET 0.271 0.267 0.267 rg BT 130.110 595.205 Td /F1 9.8 Tf [( . Such variability may be accounted for in part by differences in methods of )] TJ ET BT 26.250 579.761 Td /F1 9.8 Tf [(ascertainment, prevalence method used \(period or point prevalence\) and diagnostic/age of onset criteria. Low )] TJ ET BT 26.250 564.317 Td /F1 9.8 Tf [(prevalence rates of less than 1 case per 100,000 have been reported in Japanese populations)] TJ ET 0.267 0.267 0.267 rg BT 484.890 566.272 Td /F4 8.7 Tf [(11)] TJ ET BT 496.954 566.272 Td /F4 8.7 Tf [(12)] TJ ET 0.271 0.267 0.267 rg BT 509.018 564.317 Td /F1 9.8 Tf [( . Well )] TJ ET BT 26.250 548.873 Td /F1 9.8 Tf [(developed medical services in Japan mean under-ascertainment is unlikely)] TJ ET 0.267 0.267 0.267 rg BT 392.645 550.828 Td /F4 8.7 Tf [(12)] TJ ET 0.271 0.267 0.267 rg BT 404.709 546.195 Td /F1 8.7 Tf [(.. )] TJ ET BT 412.977 548.873 Td /F1 9.8 Tf [(More recently, Warby et al \(2011\))] TJ ET 0.267 0.267 0.267 rg BT 26.250 535.384 Td /F4 8.7 Tf [(16)] TJ ET 0.271 0.267 0.267 rg BT 38.314 533.429 Td /F1 9.8 Tf [( have summarised prevalence data from around the world and discussed the reasons for low prevalence in )] TJ ET BT 26.250 517.985 Td /F1 9.8 Tf [(some countries. Prevalence in African and American black populations is also considered to be lower than in )] TJ ET BT 26.250 502.541 Td /F1 9.8 Tf [(white populations)] TJ ET 0.267 0.267 0.267 rg BT 113.015 504.496 Td /F4 8.7 Tf [(17)] TJ ET BT 125.079 504.496 Td /F4 8.7 Tf [(18)] TJ ET 0.271 0.267 0.267 rg BT 137.143 502.541 Td /F1 9.8 Tf [( . However this may represent under-ascertainment)] TJ ET 0.267 0.267 0.267 rg BT 390.897 504.496 Td /F4 8.7 Tf [(12)] TJ ET 0.271 0.267 0.267 rg BT 402.961 502.541 Td /F1 9.8 Tf [( , with studies employing more )] TJ ET BT 26.250 487.097 Td /F1 9.8 Tf [(extensive methods reporting equivalent rates)] TJ ET 0.267 0.267 0.267 rg BT 250.208 489.052 Td /F4 8.7 Tf [(19)] TJ ET 0.271 0.267 0.267 rg BT 262.272 487.097 Td /F1 9.8 Tf [( . Juvenile onset HD is considered to be extremely rare, with few )] TJ ET BT 26.250 471.653 Td /F1 9.8 Tf [(clinicians ever seeing more than one case. In 1981, Hayden summarised the prevalence of JHD, expressed as a )] TJ ET BT 26.250 456.209 Td /F1 9.8 Tf [(percentage of the total number of HD cases surveyed)] TJ ET 0.267 0.267 0.267 rg BT 289.256 458.164 Td /F4 8.7 Tf [(11)] TJ ET 0.271 0.267 0.267 rg BT 301.320 456.209 Td /F1 9.8 Tf [( . Presented by country, a mean of 5.7% of HD cases )] TJ ET BT 26.250 440.765 Td /F1 9.8 Tf [(were found to be of juvenile onset, with a range of 1-9.6%. Childhood onset was rarer than adolescent onset, )] TJ ET BT 26.250 425.321 Td /F1 9.8 Tf [(with means of 1.3% and 4.4%, respectively. These findings are consistent with the widely accepted belief that )] TJ ET BT 26.250 409.877 Td /F1 9.8 Tf [(JHD is indeed a rare form of the disease.)] TJ ET BT 26.250 386.933 Td /F1 9.8 Tf [(Although Hayden s work has been the first and only summary of the epidemiology of JHD known to the authors, )] TJ ET BT 26.250 371.489 Td /F1 9.8 Tf [(there are several limitations in combining and interpreting the data in this way to obtain an estimate of the )] TJ ET BT 26.250 356.045 Td /F1 9.8 Tf [(proportion of JHD cases. The first concerns the pooling of data from different types of studies, such as those )] TJ ET BT 26.250 340.601 Td /F1 9.8 Tf [(reporting period with those reporting point prevalence. Secondly, data are included that are published in more )] TJ ET BT 26.250 325.157 Td /F1 9.8 Tf [(than one paper. Furthermore, the Hayden report includes studies which, due to differences in country and year )] TJ ET BT 26.250 309.713 Td /F1 9.8 Tf [(of study, report prevalence in populations with different age-sex structures. This potentially introduces a bias; )] TJ ET BT 26.250 294.269 Td /F1 9.8 Tf [(lower life expectancies artificially raise the proportion of cases with juvenile onset as patients with adult onset )] TJ ET BT 26.250 278.825 Td /F1 9.8 Tf [(are more likely to die prematurely from unrelated causes. The aim of the current study is therefore to update )] TJ ET BT 26.250 263.381 Td /F1 9.8 Tf [(and expand Hayden s work, exploring the impact of study level factors on the estimated proportion of HD cases )] TJ ET BT 26.250 247.937 Td /F1 9.8 Tf [(with juvenile onset.)] TJ ET BT 26.250 207.142 Td /F4 12.0 Tf [(Methods)] TJ ET BT 26.250 183.485 Td /F1 9.8 Tf [(We searched the MEDLINE and EMBASE databases for the period 1981-May 2011. The following search terms )] TJ ET BT 26.250 168.041 Td /F1 9.8 Tf [(were used in the title and abstract field:)] TJ ET BT 26.250 145.097 Td /F1 9.8 Tf [(Huntington s AND disease AND Prevalence)] TJ ET BT 26.250 122.153 Td /F1 9.8 Tf [(Huntington s AND disease AND Population)] TJ ET BT 26.250 99.209 Td /F1 9.8 Tf [(Huntington s AND disease AND Epidemiology*)] TJ ET BT 26.250 76.265 Td /F1 9.8 Tf [(Huntington s AND disease AND Incidence)] TJ ET BT 26.250 53.321 Td /F1 9.8 Tf [(Huntington*AND Prevalence)] TJ ET Q q 15.000 42.732 577.500 734.268 re W n 0.271 0.267 0.267 rg BT 26.250 764.645 Td /F1 9.8 Tf [(presentation; the dominant motor feature being a parkinsonian type syndrome of rigidity, dystonia and )] TJ ET BT 26.250 749.201 Td /F1 9.8 Tf [(bradykinesia, rather than chorea)] TJ ET 0.267 0.267 0.267 rg BT 186.735 751.156 Td /F4 8.7 Tf [(2)] TJ ET BT 192.767 751.156 Td /F4 8.7 Tf [(3)] TJ ET BT 198.799 751.156 Td /F4 8.7 Tf [(4)] TJ ET 0.271 0.267 0.267 rg BT 204.831 749.201 Td /F1 9.8 Tf [( . In addition, childhood cases may also present with cerebellar signs, )] TJ ET BT 26.250 733.757 Td /F1 9.8 Tf [(epilepsy, myoclonus and spasticity)] TJ ET 0.267 0.267 0.267 rg BT 196.894 735.712 Td /F4 8.7 Tf [(5)] TJ ET BT 202.927 735.712 Td /F4 8.7 Tf [(6)] TJ ET 0.271 0.267 0.267 rg BT 208.959 733.757 Td /F1 9.8 Tf [( . Behavioural problems and cognitive decline are also common in JHD)] TJ ET 0.267 0.267 0.267 rg BT 552.977 735.712 Td /F4 8.7 Tf [(4)] TJ ET BT 559.010 735.712 Td /F4 8.7 Tf [(6)] TJ ET 0.271 0.267 0.267 rg BT 565.042 733.757 Td /F1 9.8 Tf [( , )] TJ ET BT 26.250 718.313 Td /F1 9.8 Tf [(with additional features of developmental delay and autism in childhood cases)] TJ ET 0.267 0.267 0.267 rg BT 411.394 720.268 Td /F4 8.7 Tf [(5)] TJ ET 0.271 0.267 0.267 rg BT 417.427 718.313 Td /F1 9.8 Tf [( .)] TJ ET BT 26.250 695.369 Td /F1 9.8 Tf [(The causative mutation in HD has been identified as an expanded CAG repeat sequence in the first exon of the )] TJ ET BT 26.250 679.925 Td /F1 9.8 Tf [(HTT gene )] TJ ET 0.267 0.267 0.267 rg BT 76.063 681.880 Td /F4 8.7 Tf [(7)] TJ ET 0.271 0.267 0.267 rg BT 82.095 679.925 Td /F1 9.8 Tf [( . A CAG repeat of ? 40 is unequivocally fully penetrant, with CAG repeats of 36-39 showing reduced )] TJ ET BT 26.250 664.481 Td /F1 9.8 Tf [(penetrance)] TJ ET 0.267 0.267 0.267 rg BT 81.962 666.436 Td /F4 8.7 Tf [(8)] TJ ET 0.271 0.267 0.267 rg BT 87.994 664.481 Td /F1 9.8 Tf [( . JHD is usually associated with a CAG repeat of ? 60 repeats in approximately 50% of cases)] TJ ET 0.267 0.267 0.267 rg BT 540.959 666.436 Td /F4 8.7 Tf [(9)] TJ ET 0.271 0.267 0.267 rg BT 546.991 664.481 Td /F1 9.8 Tf [( , with )] TJ ET BT 26.250 649.037 Td /F1 9.8 Tf [(childhood onset often exhibiting a repeat size of ? 80)] TJ ET 0.267 0.267 0.267 rg BT 286.380 650.992 Td /F4 8.7 Tf [(5)] TJ ET BT 292.412 650.992 Td /F4 8.7 Tf [(10)] TJ ET 0.271 0.267 0.267 rg BT 304.476 649.037 Td /F1 9.8 Tf [( . However, consistent with findings in adult cases,CAG )] TJ ET BT 26.250 633.593 Td /F1 9.8 Tf [(repeat size does not always correlate with age of onset in JHD)] TJ ET 0.267 0.267 0.267 rg BT 329.699 635.548 Td /F4 8.7 Tf [(5)] TJ ET 0.271 0.267 0.267 rg BT 335.731 633.593 Td /F1 9.8 Tf [( .)] TJ ET BT 26.250 610.649 Td /F1 9.8 Tf [(The prevalence of HD is considered to be approximately 4-10 cases per 100,000 in Caucasian populations)] TJ ET 0.267 0.267 0.267 rg BT 545.603 612.604 Td /F4 8.7 Tf [(11)] TJ ET 0.271 0.267 0.267 rg BT 557.667 610.649 Td /F1 9.8 Tf [(but )] TJ ET BT 26.250 595.205 Td /F1 9.8 Tf [(this may be higher)] TJ ET 0.267 0.267 0.267 rg BT 118.046 597.160 Td /F4 8.7 Tf [(15)] TJ ET 0.271 0.267 0.267 rg BT 130.110 595.205 Td /F1 9.8 Tf [( . Such variability may be accounted for in part by differences in methods of )] TJ ET BT 26.250 579.761 Td /F1 9.8 Tf [(ascertainment, prevalence method used \(period or point prevalence\) and diagnostic/age of onset criteria. Low )] TJ ET BT 26.250 564.317 Td /F1 9.8 Tf [(prevalence rates of less than 1 case per 100,000 have been reported in Japanese populations)] TJ ET 0.267 0.267 0.267 rg BT 484.890 566.272 Td /F4 8.7 Tf [(11)] TJ ET BT 496.954 566.272 Td /F4 8.7 Tf [(12)] TJ ET 0.271 0.267 0.267 rg BT 509.018 564.317 Td /F1 9.8 Tf [( . Well )] TJ ET BT 26.250 548.873 Td /F1 9.8 Tf [(developed medical services in Japan mean under-ascertainment is unlikely)] TJ ET 0.267 0.267 0.267 rg BT 392.645 550.828 Td /F4 8.7 Tf [(12)] TJ ET 0.271 0.267 0.267 rg BT 404.709 546.195 Td /F1 8.7 Tf [(.. )] TJ ET BT 412.977 548.873 Td /F1 9.8 Tf [(More recently, Warby et al \(2011\))] TJ ET 0.267 0.267 0.267 rg BT 26.250 535.384 Td /F4 8.7 Tf [(16)] TJ ET 0.271 0.267 0.267 rg BT 38.314 533.429 Td /F1 9.8 Tf [( have summarised prevalence data from around the world and discussed the reasons for low prevalence in )] TJ ET BT 26.250 517.985 Td /F1 9.8 Tf [(some countries. Prevalence in African and American black populations is also considered to be lower than in )] TJ ET BT 26.250 502.541 Td /F1 9.8 Tf [(white populations)] TJ ET 0.267 0.267 0.267 rg BT 113.015 504.496 Td /F4 8.7 Tf [(17)] TJ ET BT 125.079 504.496 Td /F4 8.7 Tf [(18)] TJ ET 0.271 0.267 0.267 rg BT 137.143 502.541 Td /F1 9.8 Tf [( . However this may represent under-ascertainment)] TJ ET 0.267 0.267 0.267 rg BT 390.897 504.496 Td /F4 8.7 Tf [(12)] TJ ET 0.271 0.267 0.267 rg BT 402.961 502.541 Td /F1 9.8 Tf [( , with studies employing more )] TJ ET BT 26.250 487.097 Td /F1 9.8 Tf [(extensive methods reporting equivalent rates)] TJ ET 0.267 0.267 0.267 rg BT 250.208 489.052 Td /F4 8.7 Tf [(19)] TJ ET 0.271 0.267 0.267 rg BT 262.272 487.097 Td /F1 9.8 Tf [( . Juvenile onset HD is considered to be extremely rare, with few )] TJ ET BT 26.250 471.653 Td /F1 9.8 Tf [(clinicians ever seeing more than one case. In 1981, Hayden summarised the prevalence of JHD, expressed as a )] TJ ET BT 26.250 456.209 Td /F1 9.8 Tf [(percentage of the total number of HD cases surveyed)] TJ ET 0.267 0.267 0.267 rg BT 289.256 458.164 Td /F4 8.7 Tf [(11)] TJ ET 0.271 0.267 0.267 rg BT 301.320 456.209 Td /F1 9.8 Tf [( . Presented by country, a mean of 5.7% of HD cases )] TJ ET BT 26.250 440.765 Td /F1 9.8 Tf [(were found to be of juvenile onset, with a range of 1-9.6%. Childhood onset was rarer than adolescent onset, )] TJ ET BT 26.250 425.321 Td /F1 9.8 Tf [(with means of 1.3% and 4.4%, respectively. These findings are consistent with the widely accepted belief that )] TJ ET BT 26.250 409.877 Td /F1 9.8 Tf [(JHD is indeed a rare form of the disease.)] TJ ET BT 26.250 386.933 Td /F1 9.8 Tf [(Although Hayden s work has been the first and only summary of the epidemiology of JHD known to the authors, )] TJ ET BT 26.250 371.489 Td /F1 9.8 Tf [(there are several limitations in combining and interpreting the data in this way to obtain an estimate of the )] TJ ET BT 26.250 356.045 Td /F1 9.8 Tf [(proportion of JHD cases. The first concerns the pooling of data from different types of studies, such as those )] TJ ET BT 26.250 340.601 Td /F1 9.8 Tf [(reporting period with those reporting point prevalence. Secondly, data are included that are published in more )] TJ ET BT 26.250 325.157 Td /F1 9.8 Tf [(than one paper. Furthermore, the Hayden report includes studies which, due to differences in country and year )] TJ ET BT 26.250 309.713 Td /F1 9.8 Tf [(of study, report prevalence in populations with different age-sex structures. This potentially introduces a bias; )] TJ ET BT 26.250 294.269 Td /F1 9.8 Tf [(lower life expectancies artificially raise the proportion of cases with juvenile onset as patients with adult onset )] TJ ET BT 26.250 278.825 Td /F1 9.8 Tf [(are more likely to die prematurely from unrelated causes. The aim of the current study is therefore to update )] TJ ET BT 26.250 263.381 Td /F1 9.8 Tf [(and expand Hayden s work, exploring the impact of study level factors on the estimated proportion of HD cases )] TJ ET BT 26.250 247.937 Td /F1 9.8 Tf [(with juvenile onset.)] TJ ET BT 26.250 207.142 Td /F4 12.0 Tf [(Methods)] TJ ET BT 26.250 183.485 Td /F1 9.8 Tf [(We searched the MEDLINE and EMBASE databases for the period 1981-May 2011. The following search terms )] TJ ET BT 26.250 168.041 Td /F1 9.8 Tf [(were used in the title and abstract field:)] TJ ET BT 26.250 145.097 Td /F1 9.8 Tf [(Huntington s AND disease AND Prevalence)] TJ ET BT 26.250 122.153 Td /F1 9.8 Tf [(Huntington s AND disease AND Population)] TJ ET BT 26.250 99.209 Td /F1 9.8 Tf [(Huntington s AND disease AND Epidemiology*)] TJ ET BT 26.250 76.265 Td /F1 9.8 Tf [(Huntington s AND disease AND Incidence)] TJ ET BT 26.250 53.321 Td /F1 9.8 Tf [(Huntington*AND Prevalence)] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 18.032 Td /F5 11.0 Tf [(2)] TJ ET BT 25.000 18.032 Td /F5 11.0 Tf [(PLOS Currents Huntington Disease)] TJ ET Q endstream endobj 94 0 obj << /Type /Annot /Subtype /Link /A 95 0 R /Border [0 0 0] /H /I /Rect [ 186.7350 750.1160 192.7670 761.5560 ] >> endobj 95 0 obj << /Type /Action >> endobj 96 0 obj << /Type /Annot /Subtype /Link /A 97 0 R /Border [0 0 0] /H /I /Rect [ 192.7670 750.1160 198.7990 761.5560 ] >> endobj 97 0 obj << /Type /Action >> 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No JHD cases were reported in the Bickford )] TJ ET BT 26.250 115.097 Td /F1 9.8 Tf [(and Ellison paper)] TJ ET 0.267 0.267 0.267 rg BT 110.685 117.052 Td /F4 8.7 Tf [(25)] TJ ET 0.271 0.267 0.267 rg BT 122.749 115.097 Td /F1 9.8 Tf [( and this was therefore excluded. Therefore, only the data from Pleydell)] TJ ET 0.267 0.267 0.267 rg BT 475.046 117.052 Td /F4 8.7 Tf [(26)] TJ ET BT 487.110 117.052 Td /F4 8.7 Tf [(27)] TJ ET 0.271 0.267 0.267 rg BT 499.174 115.097 Td /F1 9.8 Tf [( and Cameron )] TJ ET BT 26.250 99.653 Td /F1 9.8 Tf [(and Venters)] TJ ET 0.267 0.267 0.267 rg BT 85.452 101.608 Td /F4 8.7 Tf [(24)] TJ ET 0.271 0.267 0.267 rg BT 97.516 99.653 Td /F1 9.8 Tf [( are included in our review. Although the counts of JHD cases in the Cameron and Venters paper )] TJ ET BT 26.250 84.209 Td /F1 9.8 Tf [(are not explicitly reported, these were deduced by calculating the number of cases reported in the two Pleydell)] TJ ET 0.267 0.267 0.267 rg BT 26.250 70.720 Td /F4 8.7 Tf [(26)] TJ ET BT 38.314 70.720 Td /F4 8.7 Tf [(27)] TJ ET 0.271 0.267 0.267 rg BT 50.378 68.765 Td /F1 9.8 Tf [(studies.)] TJ ET BT 26.250 45.821 Td /F1 9.8 Tf [(Cases in the Hayden South African study)] TJ ET 0.267 0.267 0.267 rg BT 225.862 47.776 Td /F4 8.7 Tf [(28)] TJ ET 0.271 0.267 0.267 rg BT 237.926 45.821 Td /F1 9.8 Tf [(were categorised by ethnicity into white, mixed and black )] TJ ET Q q 15.000 27.288 577.500 749.712 re W n 0.271 0.267 0.267 rg BT 26.250 764.645 Td /F1 9.8 Tf [(Huntington*AND Population)] TJ ET BT 26.250 741.701 Td /F1 9.8 Tf [(Huntington*AND Epidemiology*)] TJ ET BT 26.250 718.757 Td /F1 9.8 Tf [(Huntington*AND Incidence)] TJ ET BT 26.250 695.813 Td /F1 9.8 Tf [(Juvenile AND Huntington*)] TJ ET BT 26.250 672.869 Td /F1 9.8 Tf [(\(* indicates searches including unlimited truncations of the target word\))] TJ ET BT 26.250 649.925 Td /F1 9.8 Tf [(Studies that did not include a defined HD population were excluded. Literature reviews were included if they )] TJ ET BT 26.250 634.481 Td /F1 9.8 Tf [(provided information on the total number of HD cases surveyed. Studies were excluded if they did not include )] TJ ET BT 26.250 619.037 Td /F1 9.8 Tf [(information on ages of onset, number of juvenile cases, or patients with onset before age 21. We only used )] TJ ET BT 26.250 603.593 Td /F1 9.8 Tf [(published data once. Articles not written in English were excluded, the one exception being the German )] TJ ET BT 26.250 588.149 Td /F1 9.8 Tf [(language Panse study)] TJ ET 0.267 0.267 0.267 rg BT 134.017 590.104 Td /F4 8.7 Tf [(20)] TJ ET 0.271 0.267 0.267 rg BT 146.081 588.149 Td /F1 9.8 Tf [( as it was included in the original Hayden study. For each study, data relating to the )] TJ ET BT 26.250 572.705 Td /F1 9.8 Tf [(total number of HD cases and total number of juvenile cases were extracted. In addition, the number of cases )] TJ ET BT 26.250 557.261 Td /F1 9.8 Tf [(with childhood \(onset 0-10 years\) and adolescent \(11-20 years\) was extracted if available. For each study the )] TJ ET BT 26.250 541.817 Td /F1 9.8 Tf [(proportion of HD cases with juvenile onset was calculated and expressed as a percentage.)] TJ ET BT 26.250 518.873 Td /F4 9.8 Tf [(Sub-group analyses.)] TJ ET BT 138.765 518.873 Td /F1 9.8 Tf [( Studies were subdivided based on methodology, year of publication and country )] TJ ET BT 26.250 503.429 Td /F1 9.8 Tf [(studied. Study methodology was defined as either multiple methods of ascertainment  or HD roster/clinic )] TJ ET BT 26.250 487.985 Td /F1 9.8 Tf [(population . Of these, the most accurate estimates of prevalence were considered to be from studies with )] TJ ET BT 26.250 472.541 Td /F1 9.8 Tf [(multiple methods of ascertainment. Therefore, studies meeting this criterion were used for all further sub-)] TJ ET BT 26.250 457.097 Td /F1 9.8 Tf [(analyses. To account for any biases relating to age-based population structure, studies were further divided by )] TJ ET BT 26.250 441.653 Td /F1 9.8 Tf [(economic status as defined by the World Bank)] TJ ET 0.267 0.267 0.267 rg BT 253.688 443.608 Td /F4 8.7 Tf [(21)] TJ ET 0.271 0.267 0.267 rg BT 265.752 441.653 Td /F1 9.8 Tf [( . To account for any time related changes in population )] TJ ET BT 26.250 426.209 Td /F1 9.8 Tf [(structure and to gain an accurate estimate of the current prevalence of JHD, the final sub-group analysis was )] TJ ET BT 26.250 410.765 Td /F1 9.8 Tf [(conducted using studies published between 1980 and 2011.)] TJ ET BT 26.250 387.821 Td /F4 9.8 Tf [(Statistical analysis.)] TJ ET BT 133.880 387.821 Td /F1 9.8 Tf [( Within each sub-group, study results were pooled in a meta-analysis. Proportions were )] TJ ET BT 26.250 372.377 Td /F1 9.8 Tf [(first transformed using the Freeman-Tukey double arc-sin transformation before being combined. A random )] TJ ET BT 26.250 356.933 Td /F1 9.8 Tf [(effects model was assumed for each meta analysis due to the heterogeneity in the study characteristics. For )] TJ ET BT 26.250 341.489 Td /F1 9.8 Tf [(each meta-analysis the I)] TJ ET BT 146.243 346.533 Td /F1 8.7 Tf [(2)] TJ ET BT 151.755 341.489 Td /F1 9.8 Tf [( value is reported as a measure of statistical heterogeneity. Confidence intervals )] TJ ET BT 26.250 326.045 Td /F1 9.8 Tf [(presented for each individual study were computed using the exact binomial method. All analyses were )] TJ ET BT 26.250 310.601 Td /F1 9.8 Tf [(conducted using the meta  package in R 2.13.1 )] TJ ET 0.267 0.267 0.267 rg BT 268.060 312.556 Td /F4 8.7 Tf [(22)] TJ ET 0.271 0.267 0.267 rg BT 280.124 310.601 Td /F1 9.8 Tf [( .)] TJ ET BT 26.250 269.806 Td /F4 12.0 Tf [(Results)] TJ ET BT 26.250 246.149 Td /F1 9.8 Tf [(The search criteria produced a total of 1594 articles. Of these, 48 studies met the inclusion criteria. These )] TJ ET BT 26.250 230.705 Td /F1 9.8 Tf [(studies were combined with those reported by Hayden)] TJ ET 0.267 0.267 0.267 rg BT 294.414 232.660 Td /F4 8.7 Tf [(11)] TJ ET 0.271 0.267 0.267 rg BT 306.478 230.705 Td /F1 9.8 Tf [( , increasing the total number of studies to 59. The )] TJ ET BT 26.250 215.261 Td /F1 9.8 Tf [(study by van Dijk et al)] TJ ET 0.267 0.267 0.267 rg BT 135.772 217.216 Td /F4 8.7 Tf [(2)] TJ ET 0.271 0.267 0.267 rg BT 141.804 215.261 Td /F1 9.8 Tf [( was excluded as this literature survey was specifically searching for articles with JHD )] TJ ET BT 26.250 199.817 Td /F1 9.8 Tf [(cases and did not define a denominator total HD population. Although the aim of the study was to update )] TJ ET BT 26.250 184.373 Td /F1 9.8 Tf [(Hayden s work we also included the paper by Julia Bell 1948 )] TJ ET 0.267 0.267 0.267 rg BT 324.502 186.328 Td /F4 8.7 Tf [(23)] TJ ET 0.271 0.267 0.267 rg BT 336.567 184.373 Td /F1 9.8 Tf [( .)] TJ ET BT 26.250 161.429 Td /F1 9.8 Tf [(The pooled data presented in the Cameron and Venters paper)] TJ ET 0.267 0.267 0.267 rg BT 330.528 163.384 Td /F4 8.7 Tf [(24)] TJ ET 0.271 0.267 0.267 rg BT 342.592 161.429 Td /F1 9.8 Tf [( , which originally included data from their own )] TJ ET BT 26.250 145.985 Td /F1 9.8 Tf [(sample \(Scotland\) plus that of Bickford and Ellison \(Cornwall\))] TJ ET 0.267 0.267 0.267 rg BT 325.692 147.940 Td /F4 8.7 Tf [(25)] TJ ET 0.271 0.267 0.267 rg BT 337.756 145.985 Td /F1 9.8 Tf [(and Pleydell \(Northamptonshire\))] TJ ET 0.267 0.267 0.267 rg BT 496.759 147.940 Td /F4 8.7 Tf [(26)] TJ ET BT 508.823 147.940 Td /F4 8.7 Tf [(27)] TJ ET 0.271 0.267 0.267 rg BT 520.887 145.985 Td /F1 9.8 Tf [( , has been )] TJ ET BT 26.250 130.541 Td /F1 9.8 Tf [(disaggregated to recreate counts in the three study populations. No JHD cases were reported in the Bickford )] TJ ET BT 26.250 115.097 Td /F1 9.8 Tf [(and Ellison paper)] TJ ET 0.267 0.267 0.267 rg BT 110.685 117.052 Td /F4 8.7 Tf [(25)] TJ ET 0.271 0.267 0.267 rg BT 122.749 115.097 Td /F1 9.8 Tf [( and this was therefore excluded. Therefore, only the data from Pleydell)] TJ ET 0.267 0.267 0.267 rg BT 475.046 117.052 Td /F4 8.7 Tf [(26)] TJ ET BT 487.110 117.052 Td /F4 8.7 Tf [(27)] TJ ET 0.271 0.267 0.267 rg BT 499.174 115.097 Td /F1 9.8 Tf [( and Cameron )] TJ ET BT 26.250 99.653 Td /F1 9.8 Tf [(and Venters)] TJ ET 0.267 0.267 0.267 rg BT 85.452 101.608 Td /F4 8.7 Tf [(24)] TJ ET 0.271 0.267 0.267 rg BT 97.516 99.653 Td /F1 9.8 Tf [( are included in our review. Although the counts of JHD cases in the Cameron and Venters paper )] TJ ET BT 26.250 84.209 Td /F1 9.8 Tf [(are not explicitly reported, these were deduced by calculating the number of cases reported in the two Pleydell)] TJ ET 0.267 0.267 0.267 rg BT 26.250 70.720 Td /F4 8.7 Tf [(26)] TJ ET BT 38.314 70.720 Td /F4 8.7 Tf [(27)] TJ ET 0.271 0.267 0.267 rg BT 50.378 68.765 Td /F1 9.8 Tf [(studies.)] TJ ET BT 26.250 45.821 Td /F1 9.8 Tf [(Cases in the Hayden South African study)] TJ ET 0.267 0.267 0.267 rg BT 225.862 47.776 Td /F4 8.7 Tf [(28)] TJ ET 0.271 0.267 0.267 rg BT 237.926 45.821 Td /F1 9.8 Tf [(were categorised by ethnicity into white, mixed and black )] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 18.032 Td /F5 11.0 Tf [(3)] TJ ET BT 25.000 18.032 Td /F5 11.0 Tf [(PLOS Currents Huntington Disease)] TJ ET Q endstream endobj 246 0 obj << /Type /Annot /Subtype /Link /A 247 0 R /Border [0 0 0] /H /I /Rect [ 134.0168 589.0640 146.0808 600.5040 ] >> endobj 247 0 obj << /Type /Action >> 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To avoid double counting of )] TJ ET BT 26.250 718.313 Td /F1 9.8 Tf [(data in the meta-analysis, the overall total for South Africa was not included. This produced a revised total of 62 )] TJ ET BT 26.250 702.869 Td /F1 9.8 Tf [(studies. A summary of these studies is presented in an appendix.)] TJ ET BT 26.250 679.925 Td /F1 9.8 Tf [(The results of the meta-analysis are presented as a forest plot in Figure 1. The black population data from )] TJ ET BT 26.250 664.481 Td /F1 9.8 Tf [(Hayden)] TJ ET 0.267 0.267 0.267 rg BT 63.700 666.436 Td /F4 8.7 Tf [(28)] TJ ET 0.271 0.267 0.267 rg BT 75.764 664.481 Td /F1 9.8 Tf [( were excluded for purposes of the statistical analysis since there were no HD cases reported. The )] TJ ET BT 26.250 649.037 Td /F1 9.8 Tf [(overall pooled proportion of JHD cases was 4.92% \(95% confidence interval \(CI\) 4.07% to 5.84%\), with a range )] TJ ET BT 26.250 633.593 Td /F1 9.8 Tf [(of 1-15%.)] TJ ET Q q 15.000 623.004 577.500 153.996 re W n 0.271 0.267 0.267 rg BT 26.250 764.645 Td /F1 9.8 Tf [(populations recognising that the white South African population has a mortality distribution similar to that in )] TJ ET BT 26.250 749.201 Td /F1 9.8 Tf [(countries listed as high income, whereas the mixed population has a mortality distribution similar to countries in )] TJ ET BT 26.250 733.757 Td /F1 9.8 Tf [(the upper middle income group \(no cases were reported in the black population\). To avoid double counting of )] TJ ET BT 26.250 718.313 Td /F1 9.8 Tf [(data in the meta-analysis, the overall total for South Africa was not included. This produced a revised total of 62 )] TJ ET BT 26.250 702.869 Td /F1 9.8 Tf [(studies. A summary of these studies is presented in an appendix.)] TJ ET BT 26.250 679.925 Td /F1 9.8 Tf [(The results of the meta-analysis are presented as a forest plot in Figure 1. The black population data from )] TJ ET BT 26.250 664.481 Td /F1 9.8 Tf [(Hayden)] TJ ET 0.267 0.267 0.267 rg BT 63.700 666.436 Td /F4 8.7 Tf [(28)] TJ ET 0.271 0.267 0.267 rg BT 75.764 664.481 Td /F1 9.8 Tf [( were excluded for purposes of the statistical analysis since there were no HD cases reported. The )] TJ ET BT 26.250 649.037 Td /F1 9.8 Tf [(overall pooled proportion of JHD cases was 4.92% \(95% confidence interval \(CI\) 4.07% to 5.84%\), with a range )] TJ ET BT 26.250 633.593 Td /F1 9.8 Tf [(of 1-15%.)] TJ ET Q q 15.000 623.004 577.500 153.996 re W n 0.271 0.267 0.267 rg BT 26.250 764.645 Td /F1 9.8 Tf [(populations recognising that the white South African population has a mortality distribution similar to that in )] TJ ET BT 26.250 749.201 Td /F1 9.8 Tf [(countries listed as high income, whereas the mixed population has a mortality distribution similar to countries in )] TJ ET BT 26.250 733.757 Td /F1 9.8 Tf [(the upper middle income group \(no cases were reported in the black population\). To avoid double counting of )] TJ ET BT 26.250 718.313 Td /F1 9.8 Tf [(data in the meta-analysis, the overall total for South Africa was not included. This produced a revised total of 62 )] TJ ET BT 26.250 702.869 Td /F1 9.8 Tf [(studies. A summary of these studies is presented in an appendix.)] TJ ET BT 26.250 679.925 Td /F1 9.8 Tf [(The results of the meta-analysis are presented as a forest plot in Figure 1. The black population data from )] TJ ET BT 26.250 664.481 Td /F1 9.8 Tf [(Hayden)] TJ ET 0.267 0.267 0.267 rg BT 63.700 666.436 Td /F4 8.7 Tf [(28)] TJ ET 0.271 0.267 0.267 rg BT 75.764 664.481 Td /F1 9.8 Tf [( were excluded for purposes of the statistical analysis since there were no HD cases reported. The )] TJ ET BT 26.250 649.037 Td /F1 9.8 Tf [(overall pooled proportion of JHD cases was 4.92% \(95% confidence interval \(CI\) 4.07% to 5.84%\), with a range )] TJ ET BT 26.250 633.593 Td /F1 9.8 Tf [(of 1-15%.)] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 18.032 Td /F5 11.0 Tf [(4)] TJ ET BT 25.000 18.032 Td /F5 11.0 Tf [(PLOS Currents Huntington Disease)] TJ ET Q endstream endobj 350 0 obj << /Type /Annot /Subtype /Link /A 351 0 R /Border [0 0 0] /H /I /Rect [ 63.6998 665.3960 75.7638 676.8360 ] >> endobj 351 0 obj << /Type /Action >> endobj 352 0 obj << /Type /Annot /Subtype /Link /A 353 0 R /Border [0 0 0] /H /I /Rect [ 63.6998 665.3960 75.7638 676.8360 ] >> endobj 353 0 obj << /Type /Action >> endobj 354 0 obj << /Type /Annot /Subtype /Link /A 355 0 R /Border [0 0 0] /H /I /Rect [ 63.6998 665.3960 75.7638 676.8360 ] >> endobj 355 0 obj << /Type /Action >> endobj 356 0 obj << /Type /Page /Parent 3 0 R /Annots [ 358 0 R 361 0 R 363 0 R ] /Contents 357 0 R >> endobj 357 0 obj << /Length 7240 >> stream 0.271 0.267 0.267 rg q 15.000 572.892 577.500 204.108 re W n 0.965 0.965 0.965 rg 26.250 688.056 555.000 88.944 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 777.000 m 581.250 777.000 l 581.250 776.250 l 26.250 776.250 l f 26.250 688.056 m 581.250 688.056 l 581.250 688.806 l 26.250 688.806 l f q 48.000 0 0 48.000 35.250 719.250 cm /I3 Do Q 0.500 0.500 0.500 rg BT 35.250 757.650 Td /F1 8.0 Tf [(Image not found)] TJ ET BT 35.250 747.650 Td /F1 8.0 Tf [(http://currents-stage.plos.org/hd/files/2012/04/all_jhd_studies_fig13-342x600.jpg)] TJ ET q 35.250 691.806 537.000 21.444 re W n 0.271 0.267 0.267 rg BT 35.250 700.895 Td /F4 9.8 Tf [(Fig. 1: Forest plot of all studies used in this anlysis)] TJ ET Q BT 26.250 668.201 Td /F4 9.8 Tf [(Sub-analyses. )] TJ ET BT 106.356 668.201 Td /F1 9.8 Tf [( Table 1 below summarises the results of a number of sub-group analyses of the data which are )] TJ ET BT 26.250 652.757 Td /F1 9.8 Tf [(described below.)] TJ ET BT 26.250 629.813 Td /F4 9.8 Tf [(HD roster or clinic. )] TJ ET BT 133.207 629.813 Td /F1 9.8 Tf [(Thirty-five studies reported data obtained from either a HD roster or clinic population )] TJ ET BT 26.250 614.369 Td /F1 9.8 Tf [(which are summarised in Fig 2. It is possible that a centre which uses a roster approach may have some )] TJ ET BT 26.250 598.925 Td /F1 9.8 Tf [(patients included in different studies but our final analysis was based on studies which used multiple methods )] TJ ET BT 26.250 583.481 Td /F1 9.8 Tf [(of ascertainment \(MMA\) so this is is less likely to be a problem.)] TJ ET Q q 15.000 572.892 577.500 204.108 re W n 0.965 0.965 0.965 rg 26.250 688.056 555.000 88.944 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 777.000 m 581.250 777.000 l 581.250 776.250 l 26.250 776.250 l f 26.250 688.056 m 581.250 688.056 l 581.250 688.806 l 26.250 688.806 l f q 48.000 0 0 48.000 35.250 719.250 cm /I3 Do Q 0.500 0.500 0.500 rg BT 35.250 757.650 Td /F1 8.0 Tf [(Image not found)] TJ ET BT 35.250 747.650 Td /F1 8.0 Tf [(http://currents-stage.plos.org/hd/files/2012/04/all_jhd_studies_fig13-342x600.jpg)] TJ ET q 35.250 691.806 537.000 21.444 re W n 0.271 0.267 0.267 rg BT 35.250 700.895 Td /F4 9.8 Tf [(Fig. 1: Forest plot of all studies used in this anlysis)] TJ ET Q BT 26.250 668.201 Td /F4 9.8 Tf [(Sub-analyses. )] TJ ET BT 106.356 668.201 Td /F1 9.8 Tf [( Table 1 below summarises the results of a number of sub-group analyses of the data which are )] TJ ET BT 26.250 652.757 Td /F1 9.8 Tf [(described below.)] TJ ET BT 26.250 629.813 Td /F4 9.8 Tf [(HD roster or clinic. )] TJ ET BT 133.207 629.813 Td /F1 9.8 Tf [(Thirty-five studies reported data obtained from either a HD roster or clinic population )] TJ ET BT 26.250 614.369 Td /F1 9.8 Tf [(which are summarised in Fig 2. It is possible that a centre which uses a roster approach may have some )] TJ ET BT 26.250 598.925 Td /F1 9.8 Tf [(patients included in different studies but our final analysis was based on studies which used multiple methods )] TJ ET BT 26.250 583.481 Td /F1 9.8 Tf [(of ascertainment \(MMA\) so this is is less likely to be a problem.)] TJ ET Q q 15.000 572.892 577.500 204.108 re W n 0.965 0.965 0.965 rg 26.250 688.056 555.000 88.944 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 777.000 m 581.250 777.000 l 581.250 776.250 l 26.250 776.250 l f 26.250 688.056 m 581.250 688.056 l 581.250 688.806 l 26.250 688.806 l f q 48.000 0 0 48.000 35.250 719.250 cm /I3 Do Q 0.500 0.500 0.500 rg BT 35.250 757.650 Td /F1 8.0 Tf [(Image not found)] TJ ET BT 35.250 747.650 Td /F1 8.0 Tf [(http://currents-stage.plos.org/hd/files/2012/04/all_jhd_studies_fig13-342x600.jpg)] TJ ET q 35.250 691.806 537.000 21.444 re W n 0.271 0.267 0.267 rg BT 35.250 700.895 Td /F4 9.8 Tf [(Fig. 1: Forest plot of all studies used in this anlysis)] TJ ET Q BT 26.250 668.201 Td /F4 9.8 Tf [(Sub-analyses. )] TJ ET BT 106.356 668.201 Td /F1 9.8 Tf [( Table 1 below summarises the results of a number of sub-group analyses of the data which are )] TJ ET BT 26.250 652.757 Td /F1 9.8 Tf [(described below.)] TJ ET BT 26.250 629.813 Td /F4 9.8 Tf [(HD roster or clinic. )] TJ ET BT 133.207 629.813 Td /F1 9.8 Tf [(Thirty-five studies reported data obtained from either a HD roster or clinic population )] TJ ET BT 26.250 614.369 Td /F1 9.8 Tf [(which are summarised in Fig 2. It is possible that a centre which uses a roster approach may have some )] TJ ET BT 26.250 598.925 Td /F1 9.8 Tf [(patients included in different studies but our final analysis was based on studies which used multiple methods )] TJ ET BT 26.250 583.481 Td /F1 9.8 Tf [(of ascertainment \(MMA\) so this is is less likely to be a problem.)] TJ ET Q q 48.000 0 0 48.000 35.250 719.250 cm /I3 Do Q 0.500 0.500 0.500 rg BT 35.250 757.650 Td /F1 8.0 Tf [(Image not found)] TJ ET BT 35.250 747.650 Td /F1 8.0 Tf [(http://currents-stage.plos.org/hd/files/2012/04/all_jhd_studies_fig13-342x600.jpg)] TJ ET q 0.000 0.000 0.000 rg BT 291.710 18.032 Td /F5 11.0 Tf [(5)] TJ ET BT 25.000 18.032 Td /F5 11.0 Tf [(PLOS Currents Huntington Disease)] TJ ET Q endstream endobj 358 0 obj << /Type /Annot /Subtype /Link /A 359 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 719.2500 83.2500 767.2500 ] >> endobj 359 0 obj << /Type /Action /S /URI /URI 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clinic)] TJ ET Q BT 26.250 668.201 Td /F4 9.8 Tf [(Multiple methods of ascertainment \(MMA\).)] TJ ET BT 262.590 668.201 Td /F1 9.8 Tf [( There were 25 studies applying MMA summarised in Fig 3.)] TJ ET Q q 15.000 657.612 577.500 119.388 re W n 0.965 0.965 0.965 rg 26.250 688.056 555.000 88.944 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 777.000 m 581.250 777.000 l 581.250 776.250 l 26.250 776.250 l f 26.250 688.056 m 581.250 688.056 l 581.250 688.806 l 26.250 688.806 l f q 48.000 0 0 48.000 35.250 719.250 cm /I3 Do Q 0.500 0.500 0.500 rg BT 35.250 757.650 Td /F1 8.0 Tf [(Image not found)] TJ ET BT 35.250 747.650 Td /F1 8.0 Tf [(http://currents-stage.plos.org/hd/files/2012/04/HD_rosterclinic_fig21-568x600.jpg)] TJ ET q 35.250 691.806 537.000 21.444 re W n 0.271 0.267 0.267 rg BT 35.250 700.895 Td /F4 9.8 Tf [(Fig. 2: Forest plot of studies from a roster or clinic)] TJ ET Q BT 26.250 668.201 Td /F4 9.8 Tf [(Multiple methods of ascertainment \(MMA\).)] TJ ET BT 262.590 668.201 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700.895 Td /F4 9.8 Tf [(Fig. 3: Forest plot of studies which used multiple methods of ascertainment \(MMA\))] TJ ET Q BT 26.250 668.201 Td /F4 9.8 Tf [(Income status.)] TJ ET BT 107.614 668.201 Td /F1 9.8 Tf [( The World Bank)] TJ ET 0.267 0.267 0.267 rg BT 188.061 670.156 Td /F4 8.7 Tf [(21)] TJ ET 0.271 0.267 0.267 rg BT 200.125 668.201 Td /F1 9.8 Tf [( classification of countries was used to subdivide the studies, the majority )] TJ ET BT 26.250 652.757 Td /F1 9.8 Tf [(\(22 studies\) came from the high income group. By comparison, three studies came from the upper middle )] TJ ET BT 26.250 637.313 Td /F1 9.8 Tf [(income group, two came from Venezuela)] TJ ET 0.267 0.267 0.267 rg BT 227.431 639.268 Td /F4 8.7 Tf [(10)] TJ ET BT 239.496 639.268 Td /F4 8.7 Tf [(44)] TJ ET 0.271 0.267 0.267 rg BT 251.560 637.313 Td /F1 9.8 Tf [( and the third study was that of Hayden)] TJ ET 0.267 0.267 0.267 rg BT 446.355 639.268 Td /F4 8.7 Tf [(28)] TJ ET 0.271 0.267 0.267 rg BT 458.419 637.313 Td /F1 9.8 Tf [(, where the data from )] TJ ET BT 26.250 621.869 Td /F1 9.8 Tf [(the White South African population was included in the high income analysis and data from the mixed )] TJ ET BT 26.250 606.425 Td /F1 9.8 Tf [(population was included in the middle income group. Fig 4 summarises these studies from high income )] TJ ET BT 26.250 590.981 Td /F1 9.8 Tf [(countries.)] TJ ET Q q 15.000 580.392 577.500 196.608 re W n 0.965 0.965 0.965 rg 26.250 688.056 555.000 88.944 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 777.000 m 581.250 777.000 l 581.250 776.250 l 26.250 776.250 l f 26.250 688.056 m 581.250 688.056 l 581.250 688.806 l 26.250 688.806 l f q 48.000 0 0 48.000 35.250 719.250 cm /I3 Do Q 0.500 0.500 0.500 rg BT 35.250 757.650 Td /F1 8.0 Tf [(Image not found)] TJ ET BT 35.250 747.650 Td /F1 8.0 Tf [(http://currents-stage.plos.org/hd/files/2012/04/multiple_methods_fig3-300x270.jpg)] TJ ET q 35.250 691.806 537.000 21.444 re W n 0.271 0.267 0.267 rg BT 35.250 700.895 Td /F4 9.8 Tf [(Fig. 3: Forest plot of studies which used multiple methods of ascertainment \(MMA\))] TJ ET Q BT 26.250 668.201 Td /F4 9.8 Tf [(Income status.)] TJ ET BT 107.614 668.201 Td /F1 9.8 Tf [( The World Bank)] TJ ET 0.267 0.267 0.267 rg BT 188.061 670.156 Td /F4 8.7 Tf [(21)] TJ ET 0.271 0.267 0.267 rg BT 200.125 668.201 Td /F1 9.8 Tf [( classification of countries was used to subdivide the studies, the majority )] TJ ET BT 26.250 652.757 Td /F1 9.8 Tf [(\(22 studies\) came from the high income group. By comparison, three studies came from the upper middle )] TJ ET BT 26.250 637.313 Td /F1 9.8 Tf [(income group, two came from Venezuela)] TJ ET 0.267 0.267 0.267 rg BT 227.431 639.268 Td /F4 8.7 Tf [(10)] TJ ET BT 239.496 639.268 Td /F4 8.7 Tf [(44)] TJ ET 0.271 0.267 0.267 rg BT 251.560 637.313 Td /F1 9.8 Tf [( and the third study was that of Hayden)] TJ ET 0.267 0.267 0.267 rg BT 446.355 639.268 Td /F4 8.7 Tf [(28)] TJ ET 0.271 0.267 0.267 rg BT 458.419 637.313 Td /F1 9.8 Tf [(, where the data from )] TJ ET BT 26.250 621.869 Td /F1 9.8 Tf [(the White South African population was included in the high income analysis and data from the mixed )] TJ ET BT 26.250 606.425 Td /F1 9.8 Tf [(population was included in the middle income group. Fig 4 summarises these studies from high income )] TJ ET BT 26.250 590.981 Td /F1 9.8 Tf [(countries.)] TJ ET Q q 15.000 580.392 577.500 196.608 re W n 0.965 0.965 0.965 rg 26.250 688.056 555.000 88.944 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 777.000 m 581.250 777.000 l 581.250 776.250 l 26.250 776.250 l f 26.250 688.056 m 581.250 688.056 l 581.250 688.806 l 26.250 688.806 l f q 48.000 0 0 48.000 35.250 719.250 cm /I3 Do Q 0.500 0.500 0.500 rg BT 35.250 757.650 Td /F1 8.0 Tf [(Image not found)] TJ ET BT 35.250 747.650 Td /F1 8.0 Tf [(http://currents-stage.plos.org/hd/files/2012/04/multiple_methods_fig3-300x270.jpg)] TJ ET q 35.250 691.806 537.000 21.444 re W n 0.271 0.267 0.267 rg BT 35.250 700.895 Td /F4 9.8 Tf [(Fig. 3: Forest plot of studies which used multiple methods of ascertainment \(MMA\))] TJ ET Q BT 26.250 668.201 Td /F4 9.8 Tf [(Income status.)] TJ ET BT 107.614 668.201 Td /F1 9.8 Tf [( The World Bank)] TJ ET 0.267 0.267 0.267 rg BT 188.061 670.156 Td /F4 8.7 Tf [(21)] TJ ET 0.271 0.267 0.267 rg BT 200.125 668.201 Td /F1 9.8 Tf [( classification of countries was used to subdivide the studies, the majority )] TJ ET BT 26.250 652.757 Td /F1 9.8 Tf [(\(22 studies\) came from the high income group. By comparison, three studies came from the upper middle )] TJ ET BT 26.250 637.313 Td /F1 9.8 Tf [(income group, two came from Venezuela)] TJ ET 0.267 0.267 0.267 rg BT 227.431 639.268 Td /F4 8.7 Tf [(10)] TJ ET BT 239.496 639.268 Td /F4 8.7 Tf [(44)] TJ ET 0.271 0.267 0.267 rg BT 251.560 637.313 Td /F1 9.8 Tf [( and the third study was that of Hayden)] TJ ET 0.267 0.267 0.267 rg BT 446.355 639.268 Td /F4 8.7 Tf [(28)] TJ ET 0.271 0.267 0.267 rg BT 458.419 637.313 Td /F1 9.8 Tf [(, where the data from )] TJ ET BT 26.250 621.869 Td /F1 9.8 Tf [(the White South African population was included in the high income analysis and data from the mixed )] TJ ET BT 26.250 606.425 Td /F1 9.8 Tf [(population was included in the middle income group. Fig 4 summarises these studies from high income )] TJ ET BT 26.250 590.981 Td /F1 9.8 Tf [(countries.)] TJ ET Q q 48.000 0 0 48.000 35.250 719.250 cm /I3 Do Q 0.500 0.500 0.500 rg BT 35.250 757.650 Td /F1 8.0 Tf [(Image not found)] TJ ET BT 35.250 747.650 Td /F1 8.0 Tf [(http://currents-stage.plos.org/hd/files/2012/04/multiple_methods_fig3-300x270.jpg)] TJ ET q 0.000 0.000 0.000 rg BT 291.710 18.032 Td /F5 11.0 Tf [(7)] TJ ET BT 25.000 18.032 Td /F5 11.0 Tf [(PLOS Currents Huntington Disease)] TJ ET Q endstream endobj 375 0 obj << /Type /Annot /Subtype /Link /A 376 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 719.2500 83.2500 767.2500 ] >> endobj 376 0 obj << /Type /Action /S /URI /URI (https://currents-stage.plos.org/hd/files/2012/04/multiple_methods_fig3.jpg) >> endobj 377 0 obj << /Type /Annot /Subtype /Link /A 378 0 R /Border [0 0 0] /H /I /Rect [ 188.0610 669.1160 200.1250 680.5560 ] >> endobj 378 0 obj << /Type /Action >> endobj 379 0 obj << /Type /Annot /Subtype /Link /A 380 0 R /Border [0 0 0] /H /I /Rect [ 227.4315 638.2280 239.4955 649.6680 ] >> endobj 380 0 obj << /Type /Action >> endobj 381 0 obj << /Type /Annot /Subtype /Link /A 382 0 R /Border [0 0 0] /H /I /Rect [ 239.4955 638.2280 251.5595 649.6680 ] >> endobj 382 0 obj << /Type /Action >> endobj 383 0 obj << /Type /Annot /Subtype /Link /A 384 0 R /Border [0 0 0] /H /I /Rect [ 446.3548 638.2280 458.4188 649.6680 ] >> endobj 384 0 obj << /Type /Action >> endobj 385 0 obj << /Type /Annot /Subtype /Link /A 386 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 719.2500 83.2500 767.2500 ] >> endobj 386 0 obj << /Type /Action /S /URI /URI (https://currents-stage.plos.org/hd/files/2012/04/multiple_methods_fig3.jpg) >> endobj 387 0 obj << /Type /Annot /Subtype /Link /A 388 0 R /Border [0 0 0] /H /I /Rect [ 188.0610 669.1160 200.1250 680.5560 ] >> endobj 388 0 obj << /Type /Action >> endobj 389 0 obj << /Type /Annot /Subtype /Link /A 390 0 R /Border [0 0 0] /H /I /Rect [ 227.4315 638.2280 239.4955 649.6680 ] >> endobj 390 0 obj << /Type /Action >> endobj 391 0 obj << /Type /Annot /Subtype /Link /A 392 0 R /Border [0 0 0] /H /I /Rect [ 239.4955 638.2280 251.5595 649.6680 ] >> endobj 392 0 obj << /Type /Action >> endobj 393 0 obj << /Type /Annot /Subtype /Link /A 394 0 R /Border [0 0 0] /H /I /Rect [ 446.3548 638.2280 458.4188 649.6680 ] >> endobj 394 0 obj << /Type /Action >> endobj 395 0 obj << /Type /Annot /Subtype /Link /A 396 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 719.2500 83.2500 767.2500 ] >> endobj 396 0 obj << /Type /Action /S /URI /URI (https://currents-stage.plos.org/hd/files/2012/04/multiple_methods_fig3.jpg) >> endobj 397 0 obj << /Type /Annot /Subtype /Link /A 398 0 R /Border [0 0 0] /H /I /Rect [ 188.0610 669.1160 200.1250 680.5560 ] >> endobj 398 0 obj << /Type /Action >> endobj 399 0 obj << /Type /Annot /Subtype /Link /A 400 0 R /Border [0 0 0] /H /I /Rect [ 227.4315 638.2280 239.4955 649.6680 ] >> endobj 400 0 obj << /Type /Action >> endobj 401 0 obj << /Type /Annot /Subtype /Link /A 402 0 R /Border [0 0 0] /H /I /Rect [ 239.4955 638.2280 251.5595 649.6680 ] >> endobj 402 0 obj << /Type /Action >> endobj 403 0 obj << /Type /Annot /Subtype /Link /A 404 0 R /Border [0 0 0] /H /I /Rect [ 446.3548 638.2280 458.4188 649.6680 ] >> endobj 404 0 obj << /Type /Action >> endobj 405 0 obj << /Type /Page /Parent 3 0 R /Annots [ 407 0 R 409 0 R 411 0 R ] /Contents 406 0 R >> endobj 406 0 obj << /Length 7445 >> stream 0.500 0.500 0.500 rg q 15.000 595.836 577.500 181.164 re W n 0.965 0.965 0.965 rg 26.250 688.056 555.000 88.944 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 777.000 m 581.250 777.000 l 581.250 776.250 l 26.250 776.250 l f 26.250 688.056 m 581.250 688.056 l 581.250 688.806 l 26.250 688.806 l f q 48.000 0 0 48.000 35.250 719.250 cm /I3 Do Q 0.500 0.500 0.500 rg BT 35.250 757.650 Td /F1 8.0 Tf [(Image not found)] TJ ET BT 35.250 747.650 Td /F1 8.0 Tf [(http://currents-stage.plos.org/hd/files/2012/04/MMA_high_income_fig4-300x242.jpg)] TJ ET q 35.250 691.806 537.000 21.444 re W n 0.271 0.267 0.267 rg BT 35.250 700.895 Td /F4 9.8 Tf [(Fig. 4: Forest plot of studies using MMA from high income countries)] TJ ET Q BT 26.250 668.201 Td /F4 9.8 Tf [(Post 1980 studies.)] TJ ET BT 128.332 668.201 Td /F1 9.8 Tf [( Of the MMA studies, 14 were published between 1980 and 2011. 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Ten were conducted in )] TJ ET BT 26.250 652.757 Td /F1 9.8 Tf [(high income and three in the upper middle income. As above, the final study was that of Hayden)] TJ ET BT 500.353 657.801 Td /F1 8.7 Tf [(28)] TJ ET BT 511.378 652.757 Td /F1 9.8 Tf [(, where the )] TJ ET BT 26.250 637.313 Td /F1 9.8 Tf [(data from the white South African population was included in the high income analysis and data from the mixed )] TJ ET BT 26.250 621.869 Td /F1 9.8 Tf [(population was included in the upper middle income group. 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[(http://currents-stage.plos.org/hd/files/2012/04/MMA_uppermiddle_income-600x225.jpg)] TJ ET q 35.250 691.806 537.000 21.444 re W n 0.271 0.267 0.267 rg BT 35.250 700.895 Td /F4 9.8 Tf [(Fig. 6: Forest plot of post 1980 studies using MMA from upper middle income countries)] TJ ET Q Q q 48.000 0 0 48.000 35.250 719.250 cm /I3 Do Q 0.500 0.500 0.500 rg BT 35.250 757.650 Td /F4 8.0 Tf [(Image not found)] TJ ET BT 35.250 747.650 Td /F4 8.0 Tf [(http://currents-stage.plos.org/hd/files/2012/04/MMA_uppermiddle_income-600x225.jpg)] TJ ET q 0.000 0.000 0.000 rg BT 291.710 18.032 Td /F5 11.0 Tf [(10)] TJ ET BT 25.000 18.032 Td /F5 11.0 Tf [(PLOS Currents Huntington Disease)] TJ ET Q endstream endobj 423 0 obj << /Type /Annot /Subtype /Link /A 424 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 719.2500 83.2500 767.2500 ] >> endobj 424 0 obj << /Type /Action /S /URI /URI (https://currents-stage.plos.org/hd/files/2012/04/MMA_uppermiddle_income.jpg) >> endobj 425 0 obj << /Type /Annot /Subtype /Link /A 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725.550 l 580.500 750.930 l f 26.250 751.680 m 26.250 725.550 l 27.000 725.550 l 27.000 750.930 l f 0.271 0.267 0.267 rg BT 33.000 735.426 Td /F1 9.0 Tf [(Summary of Meta-Analyses)] TJ ET 1.000 1.000 1.000 rg 26.250 500.793 555.000 224.757 re f 0.965 0.965 0.965 rg 27.000 678.093 175.904 46.707 re f 0.267 0.267 0.267 rg 26.625 724.425 176.279 0.750 re f 26.625 677.718 0.750 47.457 re f 0.271 0.267 0.267 rg BT 31.500 712.445 Td /F4 9.8 Tf [(Study type)] TJ ET 0.965 0.965 0.965 rg 202.904 678.093 94.406 46.707 re f 0.267 0.267 0.267 rg 202.904 724.425 94.406 0.750 re f 0.271 0.267 0.267 rg BT 207.404 712.445 Td /F4 9.8 Tf [(number)] TJ ET 0.965 0.965 0.965 rg 297.311 678.093 74.104 46.707 re f 0.267 0.267 0.267 rg 297.311 724.425 74.104 0.750 re f 0.271 0.267 0.267 rg BT 301.811 712.445 Td /F4 9.8 Tf [(Mean )] TJ ET BT 301.811 697.001 Td /F4 9.8 Tf [(%)] TJ ET 0.965 0.965 0.965 rg 371.415 678.093 129.030 46.707 re f 0.267 0.267 0.267 rg 371.415 724.425 129.030 0.750 re f 0.271 0.267 0.267 rg BT 375.915 712.445 Td /F4 9.8 Tf [(95%)] TJ ET BT 375.915 697.001 Td /F4 9.8 Tf [(Confidence)] TJ ET BT 375.915 681.557 Td /F4 9.8 Tf [(Interval)] TJ ET 0.965 0.965 0.965 rg 500.444 678.093 80.056 46.707 re f 0.267 0.267 0.267 rg 500.444 724.425 80.431 0.750 re f 580.125 677.718 0.750 47.457 re f 0.271 0.267 0.267 rg BT 504.944 712.445 Td /F4 9.8 Tf [(Range)] TJ ET BT 504.944 697.001 Td /F4 9.8 Tf [(%)] TJ ET 0.267 0.267 0.267 rg 26.625 677.718 176.654 0.750 re f 26.625 659.568 0.750 18.900 re f 0.271 0.267 0.267 rg BT 31.875 666.048 Td /F1 9.8 Tf [(All studies)] TJ ET 0.267 0.267 0.267 rg 202.529 677.718 95.156 0.750 re f 202.529 659.568 0.750 18.900 re f 0.271 0.267 0.267 rg BT 207.779 666.048 Td /F1 9.8 Tf [(62)] TJ ET 0.267 0.267 0.267 rg 296.936 677.718 74.854 0.750 re f 296.936 659.568 0.750 18.900 re f 0.271 0.267 0.267 rg BT 302.186 666.048 Td /F1 9.8 Tf [(4.92)] TJ ET 0.267 0.267 0.267 rg 371.040 677.718 129.780 0.750 re f 371.040 659.568 0.750 18.900 re f 0.271 0.267 0.267 rg BT 376.290 666.048 Td /F1 9.8 Tf [(4.07-5.84)] TJ ET 0.267 0.267 0.267 rg 500.069 677.718 80.806 0.750 re f 500.069 659.568 0.750 18.900 re f 580.125 659.568 0.750 18.900 re f 0.271 0.267 0.267 rg BT 505.319 666.048 Td /F1 9.8 Tf [(1-15)] TJ ET 0.267 0.267 0.267 rg 26.625 659.568 176.654 0.750 re f 26.625 641.418 0.750 18.900 re f 0.271 0.267 0.267 rg BT 31.875 647.898 Td /F1 9.8 Tf [(HD clinic/Roster)] TJ ET 0.267 0.267 0.267 rg 202.529 659.568 95.156 0.750 re f 202.529 641.418 0.750 18.900 re f 0.271 0.267 0.267 rg BT 207.779 647.898 Td /F1 9.8 Tf [(35)] TJ ET 0.267 0.267 0.267 rg 296.936 659.568 74.854 0.750 re f 296.936 641.418 0.750 18.900 re f 0.271 0.267 0.267 rg BT 302.186 647.898 Td /F1 9.8 Tf [(4.94)] TJ ET 0.267 0.267 0.267 rg 371.040 659.568 129.780 0.750 re f 371.040 641.418 0.750 18.900 re f 0.271 0.267 0.267 rg BT 376.290 647.898 Td /F1 9.8 Tf [(3.85-6.16)] TJ ET 0.267 0.267 0.267 rg 500.069 659.568 80.806 0.750 re f 500.069 641.418 0.750 18.900 re f 580.125 641.418 0.750 18.900 re f 0.271 0.267 0.267 rg BT 505.319 647.898 Td /F1 9.8 Tf [(1-15)] TJ ET 0.267 0.267 0.267 rg 26.625 641.418 176.654 0.750 re f 26.625 603.468 0.750 38.700 re f 0.271 0.267 0.267 rg BT 31.875 629.748 Td /F1 9.8 Tf [(Multiple Metods )] TJ ET BT 31.875 619.848 Td /F1 9.8 Tf [(of Ascertainment)] TJ ET BT 31.875 609.948 Td /F1 9.8 Tf [(MMA)] TJ ET 0.267 0.267 0.267 rg 202.529 641.418 95.156 0.750 re f 202.529 603.468 0.750 38.700 re f 0.271 0.267 0.267 rg BT 207.779 629.748 Td /F1 9.8 Tf [(25)] TJ ET 0.267 0.267 0.267 rg 296.936 641.418 74.854 0.750 re f 296.936 603.468 0.750 38.700 re f 0.271 0.267 0.267 rg BT 302.186 629.748 Td /F1 9.8 Tf [(5.32)] TJ ET 0.267 0.267 0.267 rg 371.040 641.418 129.780 0.750 re f 371.040 603.468 0.750 38.700 re f 0.271 0.267 0.267 rg BT 376.290 629.748 Td /F1 9.8 Tf [(4.18-6.60)] TJ ET 0.267 0.267 0.267 rg 500.069 641.418 80.806 0.750 re f 500.069 603.468 0.750 38.700 re f 580.125 603.468 0.750 38.700 re f 0.271 0.267 0.267 rg BT 505.319 629.748 Td /F1 9.8 Tf [(1-15)] TJ ET 0.267 0.267 0.267 rg 26.625 603.468 176.654 0.750 re f 26.625 585.318 0.750 18.900 re f 0.271 0.267 0.267 rg BT 31.875 591.798 Td /F1 9.8 Tf [(MMA + High Income)] TJ ET 0.267 0.267 0.267 rg 202.529 603.468 95.156 0.750 re f 202.529 585.318 0.750 18.900 re f 0.271 0.267 0.267 rg BT 207.779 591.798 Td /F1 9.8 Tf [(22)] TJ ET 0.267 0.267 0.267 rg 296.936 603.468 74.854 0.750 re f 296.936 585.318 0.750 18.900 re f 0.271 0.267 0.267 rg BT 302.186 591.798 Td /F1 9.8 Tf [(4.70)] TJ ET 0.267 0.267 0.267 rg 371.040 603.468 129.780 0.750 re f 371.040 585.318 0.750 18.900 re f 0.271 0.267 0.267 rg BT 376.290 591.798 Td /F1 9.8 Tf [(3.71-5.80)] TJ ET 0.267 0.267 0.267 rg 500.069 603.468 80.806 0.750 re f 500.069 585.318 0.750 18.900 re f 580.125 585.318 0.750 18.900 re f 0.271 0.267 0.267 rg BT 505.319 591.798 Td /F1 9.8 Tf [(1-12)] TJ ET 0.267 0.267 0.267 rg 26.625 585.318 176.654 0.750 re f 26.625 557.268 0.750 28.800 re f 0.271 0.267 0.267 rg BT 31.875 573.648 Td /F1 9.8 Tf [(MMA + Upper)] TJ ET BT 31.875 563.748 Td /F1 9.8 Tf [(Middle Income)] TJ ET 0.267 0.267 0.267 rg 202.529 585.318 95.156 0.750 re f 202.529 557.268 0.750 28.800 re f 0.271 0.267 0.267 rg BT 207.779 573.648 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 296.936 585.318 74.854 0.750 re f 296.936 557.268 0.750 28.800 re f 0.271 0.267 0.267 rg BT 302.186 573.648 Td /F1 9.8 Tf [(9.95)] TJ ET 0.267 0.267 0.267 rg 371.040 585.318 129.780 0.750 re f 371.040 557.268 0.750 28.800 re f 0.271 0.267 0.267 rg BT 376.290 573.648 Td /F1 9.8 Tf [(6.37-14.22)] TJ ET 0.267 0.267 0.267 rg 500.069 585.318 80.806 0.750 re f 500.069 557.268 0.750 28.800 re f 580.125 557.268 0.750 28.800 re f 0.271 0.267 0.267 rg BT 505.319 573.648 Td /F1 9.8 Tf [(6-15)] TJ ET 0.267 0.267 0.267 rg 26.625 557.268 176.654 0.750 re f 26.625 529.218 0.750 28.800 re f 0.271 0.267 0.267 rg BT 31.875 545.598 Td /F1 9.8 Tf [(MMA + Post 1980 +)] TJ ET BT 31.875 535.698 Td /F1 9.8 Tf [(High Income)] TJ ET 0.267 0.267 0.267 rg 202.529 557.268 95.156 0.750 re f 202.529 529.218 0.750 28.800 re f 0.271 0.267 0.267 rg BT 207.779 545.598 Td /F1 9.8 Tf [(11)] TJ ET 0.267 0.267 0.267 rg 296.936 557.268 74.854 0.750 re f 296.936 529.218 0.750 28.800 re f 0.271 0.267 0.267 rg BT 302.186 545.598 Td /F1 9.8 Tf [(4.81)] TJ ET 0.267 0.267 0.267 rg 371.040 557.268 129.780 0.750 re f 371.040 529.218 0.750 28.800 re f 0.271 0.267 0.267 rg BT 376.290 545.598 Td /F1 9.8 Tf [(3.31-6.58)] TJ ET 0.267 0.267 0.267 rg 500.069 557.268 80.806 0.750 re f 500.069 529.218 0.750 28.800 re f 580.125 529.218 0.750 28.800 re f 0.271 0.267 0.267 rg BT 505.319 545.598 Td /F1 9.8 Tf [(1-10)] TJ ET 0.267 0.267 0.267 rg 26.625 529.218 176.654 0.750 re f 26.625 501.168 176.654 0.750 re f 26.625 501.168 0.750 28.800 re f 0.271 0.267 0.267 rg BT 31.875 517.548 Td /F1 9.8 Tf [(MMA + Post 1980 +)] TJ ET BT 31.875 507.648 Td /F1 9.8 Tf [(Upper Middle Income)] TJ ET 0.267 0.267 0.267 rg 202.529 529.218 95.156 0.750 re f 202.529 501.168 95.156 0.750 re f 202.529 501.168 0.750 28.800 re f 0.271 0.267 0.267 rg BT 207.779 517.548 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 296.936 529.218 74.854 0.750 re f 296.936 501.168 74.854 0.750 re f 296.936 501.168 0.750 28.800 re f 0.271 0.267 0.267 rg BT 302.186 517.548 Td /F1 9.8 Tf [(9.95)] TJ ET 0.267 0.267 0.267 rg 371.040 529.218 129.780 0.750 re f 371.040 501.168 129.780 0.750 re f 371.040 501.168 0.750 28.800 re f 0.271 0.267 0.267 rg BT 376.290 517.548 Td /F1 9.8 Tf [(6.37- 14.22)] TJ ET 0.267 0.267 0.267 rg 500.069 529.218 80.806 0.750 re f 500.069 501.168 80.806 0.750 re f 500.069 501.168 0.750 28.800 re f 580.125 501.168 0.750 28.800 re f 0.271 0.267 0.267 rg BT 505.319 517.548 Td /F1 9.8 Tf [(6-15)] TJ ET BT 26.250 450.938 Td /F1 9.8 Tf [(Data on childhood and adolescent onset cases was available for 42 studies, representing 475 cases. Of these, )] TJ ET BT 26.250 435.494 Td /F1 9.8 Tf [(111 \(23.4%\) and 364 \(76.6%\) were childhood and adolescent onset, respectively. Only seven studies found a )] TJ ET BT 26.250 420.050 Td /F1 9.8 Tf [(higher proportion of childhood onset cases, with two studies reporting equal numbers. Therefore in 76% of )] TJ ET BT 26.250 404.606 Td /F1 9.8 Tf [(studies, adolescent onset occurred more frequently than childhood onset. When we consider just the most )] TJ ET BT 26.250 389.162 Td /F1 9.8 Tf [(recent studies of the highest quality from the high income group \(the MMA-post 1980 studies\), the pattern is )] TJ ET BT 26.250 373.718 Td /F1 9.8 Tf [(similar with 40 out of 50 \(80%\) cases being of adolescent onset.)] TJ ET BT 26.250 332.923 Td /F4 12.0 Tf [(Discussion)] TJ ET BT 26.250 309.266 Td /F4 9.8 Tf [(Main results.)] TJ ET BT 97.883 309.266 Td /F1 9.8 Tf [( In the meta-analysis of all the studies identified in this review we estimate the proportion of JHD )] TJ ET BT 26.250 293.822 Td /F1 9.8 Tf [(cases to be 4.92% \(95% CI 4.07%  5.84%\). In order to expand on Hayden s original work)] TJ ET 0.267 0.267 0.267 rg BT 464.308 295.777 Td /F4 8.7 Tf [(11)] TJ ET 0.271 0.267 0.267 rg BT 476.372 293.822 Td /F1 9.8 Tf [( and produce more )] TJ ET BT 26.250 278.378 Td /F1 9.8 Tf [(robust estimates of the proportion of JHD cases, the potential sources of bias associated with the various )] TJ ET BT 26.250 262.934 Td /F1 9.8 Tf [(studies were considered. We identified 35 studies which were based on clinic lists or rosters \(Figure 2\); and 25 )] TJ ET BT 26.250 247.490 Td /F1 9.8 Tf [(studies which used multiple methods of ascertainment \(Figure 3\). These gave mean estimates of the proportion )] TJ ET BT 26.250 232.046 Td /F1 9.8 Tf [(of 4.94% and 5.32% respectively. A clinic list or roster approach may downwardly bias the proportion of JHD )] TJ ET BT 26.250 216.602 Td /F1 9.8 Tf [(cases if it is perceived that the clinic serves mainly adult patients. Studies with multiple methods of )] TJ ET BT 26.250 201.158 Td /F1 9.8 Tf [(ascertainment are more likely to give a robust estimate.)] TJ ET Q q 15.000 28.629 577.500 748.371 re W n q 26.250 759.180 555.000 17.820 re W n 0.271 0.267 0.267 rg BT 26.250 762.744 Td /F1 9.8 Tf [(Table 1)] TJ ET Q 0.965 0.965 0.965 rg 26.250 725.550 555.000 26.130 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 751.680 m 581.250 751.680 l 580.500 750.930 l 27.000 750.930 l f 581.250 751.680 m 581.250 725.550 l 580.500 725.550 l 580.500 750.930 l f 26.250 751.680 m 26.250 725.550 l 27.000 725.550 l 27.000 750.930 l f 0.271 0.267 0.267 rg BT 33.000 735.426 Td /F1 9.0 Tf [(Summary of Meta-Analyses)] TJ ET 1.000 1.000 1.000 rg 26.250 500.793 555.000 224.757 re f 0.965 0.965 0.965 rg 27.000 678.093 175.904 46.707 re f 0.267 0.267 0.267 rg 26.625 724.425 176.279 0.750 re f 26.625 677.718 0.750 47.457 re f 0.271 0.267 0.267 rg BT 31.500 712.445 Td /F4 9.8 Tf [(Study type)] TJ ET 0.965 0.965 0.965 rg 202.904 678.093 94.406 46.707 re f 0.267 0.267 0.267 rg 202.904 724.425 94.406 0.750 re f 0.271 0.267 0.267 rg BT 207.404 712.445 Td /F4 9.8 Tf [(number)] TJ ET 0.965 0.965 0.965 rg 297.311 678.093 74.104 46.707 re f 0.267 0.267 0.267 rg 297.311 724.425 74.104 0.750 re f 0.271 0.267 0.267 rg BT 301.811 712.445 Td /F4 9.8 Tf [(Mean )] TJ ET BT 301.811 697.001 Td /F4 9.8 Tf [(%)] TJ ET 0.965 0.965 0.965 rg 371.415 678.093 129.030 46.707 re f 0.267 0.267 0.267 rg 371.415 724.425 129.030 0.750 re f 0.271 0.267 0.267 rg BT 375.915 712.445 Td /F4 9.8 Tf [(95%)] TJ ET BT 375.915 697.001 Td /F4 9.8 Tf [(Confidence)] TJ ET BT 375.915 681.557 Td /F4 9.8 Tf [(Interval)] TJ ET 0.965 0.965 0.965 rg 500.444 678.093 80.056 46.707 re f 0.267 0.267 0.267 rg 500.444 724.425 80.431 0.750 re f 580.125 677.718 0.750 47.457 re f 0.271 0.267 0.267 rg BT 504.944 712.445 Td /F4 9.8 Tf [(Range)] TJ ET BT 504.944 697.001 Td /F4 9.8 Tf [(%)] TJ ET 0.267 0.267 0.267 rg 26.625 677.718 176.654 0.750 re f 26.625 659.568 0.750 18.900 re f 0.271 0.267 0.267 rg BT 31.875 666.048 Td /F1 9.8 Tf [(All studies)] TJ ET 0.267 0.267 0.267 rg 202.529 677.718 95.156 0.750 re f 202.529 659.568 0.750 18.900 re f 0.271 0.267 0.267 rg BT 207.779 666.048 Td /F1 9.8 Tf [(62)] TJ ET 0.267 0.267 0.267 rg 296.936 677.718 74.854 0.750 re f 296.936 659.568 0.750 18.900 re f 0.271 0.267 0.267 rg BT 302.186 666.048 Td /F1 9.8 Tf [(4.92)] TJ ET 0.267 0.267 0.267 rg 371.040 677.718 129.780 0.750 re f 371.040 659.568 0.750 18.900 re f 0.271 0.267 0.267 rg BT 376.290 666.048 Td /F1 9.8 Tf [(4.07-5.84)] TJ ET 0.267 0.267 0.267 rg 500.069 677.718 80.806 0.750 re f 500.069 659.568 0.750 18.900 re f 580.125 659.568 0.750 18.900 re f 0.271 0.267 0.267 rg BT 505.319 666.048 Td /F1 9.8 Tf [(1-15)] TJ ET 0.267 0.267 0.267 rg 26.625 659.568 176.654 0.750 re f 26.625 641.418 0.750 18.900 re f 0.271 0.267 0.267 rg BT 31.875 647.898 Td /F1 9.8 Tf [(HD clinic/Roster)] TJ ET 0.267 0.267 0.267 rg 202.529 659.568 95.156 0.750 re f 202.529 641.418 0.750 18.900 re f 0.271 0.267 0.267 rg BT 207.779 647.898 Td /F1 9.8 Tf [(35)] TJ ET 0.267 0.267 0.267 rg 296.936 659.568 74.854 0.750 re f 296.936 641.418 0.750 18.900 re f 0.271 0.267 0.267 rg BT 302.186 647.898 Td /F1 9.8 Tf [(4.94)] TJ ET 0.267 0.267 0.267 rg 371.040 659.568 129.780 0.750 re f 371.040 641.418 0.750 18.900 re f 0.271 0.267 0.267 rg BT 376.290 647.898 Td /F1 9.8 Tf [(3.85-6.16)] TJ ET 0.267 0.267 0.267 rg 500.069 659.568 80.806 0.750 re f 500.069 641.418 0.750 18.900 re f 580.125 641.418 0.750 18.900 re f 0.271 0.267 0.267 rg BT 505.319 647.898 Td /F1 9.8 Tf [(1-15)] TJ ET 0.267 0.267 0.267 rg 26.625 641.418 176.654 0.750 re f 26.625 603.468 0.750 38.700 re f 0.271 0.267 0.267 rg BT 31.875 629.748 Td /F1 9.8 Tf [(Multiple Metods )] TJ ET BT 31.875 619.848 Td /F1 9.8 Tf [(of Ascertainment)] TJ ET BT 31.875 609.948 Td /F1 9.8 Tf [(MMA)] TJ ET 0.267 0.267 0.267 rg 202.529 641.418 95.156 0.750 re f 202.529 603.468 0.750 38.700 re f 0.271 0.267 0.267 rg BT 207.779 629.748 Td /F1 9.8 Tf [(25)] TJ ET 0.267 0.267 0.267 rg 296.936 641.418 74.854 0.750 re f 296.936 603.468 0.750 38.700 re f 0.271 0.267 0.267 rg BT 302.186 629.748 Td /F1 9.8 Tf [(5.32)] TJ ET 0.267 0.267 0.267 rg 371.040 641.418 129.780 0.750 re f 371.040 603.468 0.750 38.700 re f 0.271 0.267 0.267 rg BT 376.290 629.748 Td /F1 9.8 Tf [(4.18-6.60)] TJ ET 0.267 0.267 0.267 rg 500.069 641.418 80.806 0.750 re f 500.069 603.468 0.750 38.700 re f 580.125 603.468 0.750 38.700 re f 0.271 0.267 0.267 rg BT 505.319 629.748 Td /F1 9.8 Tf [(1-15)] TJ ET 0.267 0.267 0.267 rg 26.625 603.468 176.654 0.750 re f 26.625 585.318 0.750 18.900 re f 0.271 0.267 0.267 rg BT 31.875 591.798 Td /F1 9.8 Tf [(MMA + High Income)] TJ ET 0.267 0.267 0.267 rg 202.529 603.468 95.156 0.750 re f 202.529 585.318 0.750 18.900 re f 0.271 0.267 0.267 rg BT 207.779 591.798 Td /F1 9.8 Tf [(22)] TJ ET 0.267 0.267 0.267 rg 296.936 603.468 74.854 0.750 re f 296.936 585.318 0.750 18.900 re f 0.271 0.267 0.267 rg BT 302.186 591.798 Td /F1 9.8 Tf [(4.70)] TJ ET 0.267 0.267 0.267 rg 371.040 603.468 129.780 0.750 re f 371.040 585.318 0.750 18.900 re f 0.271 0.267 0.267 rg BT 376.290 591.798 Td /F1 9.8 Tf [(3.71-5.80)] TJ ET 0.267 0.267 0.267 rg 500.069 603.468 80.806 0.750 re f 500.069 585.318 0.750 18.900 re f 580.125 585.318 0.750 18.900 re f 0.271 0.267 0.267 rg BT 505.319 591.798 Td /F1 9.8 Tf [(1-12)] TJ ET 0.267 0.267 0.267 rg 26.625 585.318 176.654 0.750 re f 26.625 557.268 0.750 28.800 re f 0.271 0.267 0.267 rg BT 31.875 573.648 Td /F1 9.8 Tf [(MMA + Upper)] TJ ET BT 31.875 563.748 Td /F1 9.8 Tf [(Middle Income)] TJ ET 0.267 0.267 0.267 rg 202.529 585.318 95.156 0.750 re f 202.529 557.268 0.750 28.800 re f 0.271 0.267 0.267 rg BT 207.779 573.648 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 296.936 585.318 74.854 0.750 re f 296.936 557.268 0.750 28.800 re f 0.271 0.267 0.267 rg BT 302.186 573.648 Td /F1 9.8 Tf [(9.95)] TJ ET 0.267 0.267 0.267 rg 371.040 585.318 129.780 0.750 re f 371.040 557.268 0.750 28.800 re f 0.271 0.267 0.267 rg BT 376.290 573.648 Td /F1 9.8 Tf [(6.37-14.22)] TJ ET 0.267 0.267 0.267 rg 500.069 585.318 80.806 0.750 re f 500.069 557.268 0.750 28.800 re f 580.125 557.268 0.750 28.800 re f 0.271 0.267 0.267 rg BT 505.319 573.648 Td /F1 9.8 Tf [(6-15)] TJ ET 0.267 0.267 0.267 rg 26.625 557.268 176.654 0.750 re f 26.625 529.218 0.750 28.800 re f 0.271 0.267 0.267 rg BT 31.875 545.598 Td /F1 9.8 Tf [(MMA + Post 1980 +)] TJ ET BT 31.875 535.698 Td /F1 9.8 Tf [(High Income)] TJ ET 0.267 0.267 0.267 rg 202.529 557.268 95.156 0.750 re f 202.529 529.218 0.750 28.800 re f 0.271 0.267 0.267 rg BT 207.779 545.598 Td /F1 9.8 Tf [(11)] TJ ET 0.267 0.267 0.267 rg 296.936 557.268 74.854 0.750 re f 296.936 529.218 0.750 28.800 re f 0.271 0.267 0.267 rg BT 302.186 545.598 Td /F1 9.8 Tf [(4.81)] TJ ET 0.267 0.267 0.267 rg 371.040 557.268 129.780 0.750 re f 371.040 529.218 0.750 28.800 re f 0.271 0.267 0.267 rg BT 376.290 545.598 Td /F1 9.8 Tf [(3.31-6.58)] TJ ET 0.267 0.267 0.267 rg 500.069 557.268 80.806 0.750 re f 500.069 529.218 0.750 28.800 re f 580.125 529.218 0.750 28.800 re f 0.271 0.267 0.267 rg BT 505.319 545.598 Td /F1 9.8 Tf [(1-10)] TJ ET 0.267 0.267 0.267 rg 26.625 529.218 176.654 0.750 re f 26.625 501.168 176.654 0.750 re f 26.625 501.168 0.750 28.800 re f 0.271 0.267 0.267 rg BT 31.875 517.548 Td /F1 9.8 Tf [(MMA + Post 1980 +)] TJ ET BT 31.875 507.648 Td /F1 9.8 Tf [(Upper Middle Income)] TJ ET 0.267 0.267 0.267 rg 202.529 529.218 95.156 0.750 re f 202.529 501.168 95.156 0.750 re f 202.529 501.168 0.750 28.800 re f 0.271 0.267 0.267 rg BT 207.779 517.548 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 296.936 529.218 74.854 0.750 re f 296.936 501.168 74.854 0.750 re f 296.936 501.168 0.750 28.800 re f 0.271 0.267 0.267 rg BT 302.186 517.548 Td /F1 9.8 Tf [(9.95)] TJ ET 0.267 0.267 0.267 rg 371.040 529.218 129.780 0.750 re f 371.040 501.168 129.780 0.750 re f 371.040 501.168 0.750 28.800 re f 0.271 0.267 0.267 rg BT 376.290 517.548 Td /F1 9.8 Tf [(6.37- 14.22)] TJ ET 0.267 0.267 0.267 rg 500.069 529.218 80.806 0.750 re f 500.069 501.168 80.806 0.750 re f 500.069 501.168 0.750 28.800 re f 580.125 501.168 0.750 28.800 re f 0.271 0.267 0.267 rg BT 505.319 517.548 Td /F1 9.8 Tf [(6-15)] TJ ET BT 26.250 450.938 Td /F1 9.8 Tf [(Data on childhood and adolescent onset cases was available for 42 studies, representing 475 cases. Of these, )] TJ ET BT 26.250 435.494 Td /F1 9.8 Tf [(111 \(23.4%\) and 364 \(76.6%\) were childhood and adolescent onset, respectively. Only seven studies found a )] TJ ET BT 26.250 420.050 Td /F1 9.8 Tf [(higher proportion of childhood onset cases, with two studies reporting equal numbers. Therefore in 76% of )] TJ ET BT 26.250 404.606 Td /F1 9.8 Tf [(studies, adolescent onset occurred more frequently than childhood onset. When we consider just the most )] TJ ET BT 26.250 389.162 Td /F1 9.8 Tf [(recent studies of the highest quality from the high income group \(the MMA-post 1980 studies\), the pattern is )] TJ ET BT 26.250 373.718 Td /F1 9.8 Tf [(similar with 40 out of 50 \(80%\) cases being of adolescent onset.)] TJ ET BT 26.250 332.923 Td /F4 12.0 Tf [(Discussion)] TJ ET BT 26.250 309.266 Td /F4 9.8 Tf [(Main results.)] TJ ET BT 97.883 309.266 Td /F1 9.8 Tf [( In the meta-analysis of all the studies identified in this review we estimate the proportion of JHD )] TJ ET BT 26.250 293.822 Td /F1 9.8 Tf [(cases to be 4.92% \(95% CI 4.07%  5.84%\). In order to expand on Hayden s original work)] TJ ET 0.267 0.267 0.267 rg BT 464.308 295.777 Td /F4 8.7 Tf [(11)] TJ ET 0.271 0.267 0.267 rg BT 476.372 293.822 Td /F1 9.8 Tf [( and produce more )] TJ ET BT 26.250 278.378 Td /F1 9.8 Tf [(robust estimates of the proportion of JHD cases, the potential sources of bias associated with the various )] TJ ET BT 26.250 262.934 Td /F1 9.8 Tf [(studies were considered. We identified 35 studies which were based on clinic lists or rosters \(Figure 2\); and 25 )] TJ ET BT 26.250 247.490 Td /F1 9.8 Tf [(studies which used multiple methods of ascertainment \(Figure 3\). These gave mean estimates of the proportion )] TJ ET BT 26.250 232.046 Td /F1 9.8 Tf [(of 4.94% and 5.32% respectively. A clinic list or roster approach may downwardly bias the proportion of JHD )] TJ ET BT 26.250 216.602 Td /F1 9.8 Tf [(cases if it is perceived that the clinic serves mainly adult patients. Studies with multiple methods of )] TJ ET BT 26.250 201.158 Td /F1 9.8 Tf [(ascertainment are more likely to give a robust estimate.)] TJ ET Q q 15.000 28.629 577.500 748.371 re W n q 26.250 759.180 555.000 17.820 re W n 0.271 0.267 0.267 rg BT 26.250 762.744 Td /F1 9.8 Tf [(Table 1)] TJ ET Q 0.965 0.965 0.965 rg 26.250 725.550 555.000 26.130 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 751.680 m 581.250 751.680 l 580.500 750.930 l 27.000 750.930 l f 581.250 751.680 m 581.250 725.550 l 580.500 725.550 l 580.500 750.930 l f 26.250 751.680 m 26.250 725.550 l 27.000 725.550 l 27.000 750.930 l f 0.271 0.267 0.267 rg BT 33.000 735.426 Td /F1 9.0 Tf [(Summary of Meta-Analyses)] TJ ET 1.000 1.000 1.000 rg 26.250 500.793 555.000 224.757 re f 0.965 0.965 0.965 rg 27.000 678.093 175.904 46.707 re f 0.267 0.267 0.267 rg 26.625 724.425 176.279 0.750 re f 26.625 677.718 0.750 47.457 re f 0.271 0.267 0.267 rg BT 31.500 712.445 Td /F4 9.8 Tf [(Study type)] TJ ET 0.965 0.965 0.965 rg 202.904 678.093 94.406 46.707 re f 0.267 0.267 0.267 rg 202.904 724.425 94.406 0.750 re f 0.271 0.267 0.267 rg BT 207.404 712.445 Td /F4 9.8 Tf [(number)] TJ ET 0.965 0.965 0.965 rg 297.311 678.093 74.104 46.707 re f 0.267 0.267 0.267 rg 297.311 724.425 74.104 0.750 re f 0.271 0.267 0.267 rg BT 301.811 712.445 Td /F4 9.8 Tf [(Mean )] TJ ET BT 301.811 697.001 Td /F4 9.8 Tf [(%)] TJ ET 0.965 0.965 0.965 rg 371.415 678.093 129.030 46.707 re f 0.267 0.267 0.267 rg 371.415 724.425 129.030 0.750 re f 0.271 0.267 0.267 rg BT 375.915 712.445 Td /F4 9.8 Tf [(95%)] TJ ET BT 375.915 697.001 Td /F4 9.8 Tf [(Confidence)] TJ ET BT 375.915 681.557 Td /F4 9.8 Tf [(Interval)] TJ ET 0.965 0.965 0.965 rg 500.444 678.093 80.056 46.707 re f 0.267 0.267 0.267 rg 500.444 724.425 80.431 0.750 re f 580.125 677.718 0.750 47.457 re f 0.271 0.267 0.267 rg BT 504.944 712.445 Td /F4 9.8 Tf [(Range)] TJ ET BT 504.944 697.001 Td /F4 9.8 Tf [(%)] TJ ET 0.267 0.267 0.267 rg 26.625 677.718 176.654 0.750 re f 26.625 659.568 0.750 18.900 re f 0.271 0.267 0.267 rg BT 31.875 666.048 Td /F1 9.8 Tf [(All studies)] TJ ET 0.267 0.267 0.267 rg 202.529 677.718 95.156 0.750 re f 202.529 659.568 0.750 18.900 re f 0.271 0.267 0.267 rg BT 207.779 666.048 Td /F1 9.8 Tf [(62)] TJ ET 0.267 0.267 0.267 rg 296.936 677.718 74.854 0.750 re f 296.936 659.568 0.750 18.900 re f 0.271 0.267 0.267 rg BT 302.186 666.048 Td /F1 9.8 Tf [(4.92)] TJ ET 0.267 0.267 0.267 rg 371.040 677.718 129.780 0.750 re f 371.040 659.568 0.750 18.900 re f 0.271 0.267 0.267 rg BT 376.290 666.048 Td /F1 9.8 Tf [(4.07-5.84)] TJ ET 0.267 0.267 0.267 rg 500.069 677.718 80.806 0.750 re f 500.069 659.568 0.750 18.900 re f 580.125 659.568 0.750 18.900 re f 0.271 0.267 0.267 rg BT 505.319 666.048 Td /F1 9.8 Tf [(1-15)] TJ ET 0.267 0.267 0.267 rg 26.625 659.568 176.654 0.750 re f 26.625 641.418 0.750 18.900 re f 0.271 0.267 0.267 rg BT 31.875 647.898 Td /F1 9.8 Tf [(HD clinic/Roster)] TJ ET 0.267 0.267 0.267 rg 202.529 659.568 95.156 0.750 re f 202.529 641.418 0.750 18.900 re f 0.271 0.267 0.267 rg BT 207.779 647.898 Td /F1 9.8 Tf [(35)] TJ ET 0.267 0.267 0.267 rg 296.936 659.568 74.854 0.750 re f 296.936 641.418 0.750 18.900 re f 0.271 0.267 0.267 rg BT 302.186 647.898 Td /F1 9.8 Tf [(4.94)] TJ ET 0.267 0.267 0.267 rg 371.040 659.568 129.780 0.750 re f 371.040 641.418 0.750 18.900 re f 0.271 0.267 0.267 rg BT 376.290 647.898 Td /F1 9.8 Tf [(3.85-6.16)] TJ ET 0.267 0.267 0.267 rg 500.069 659.568 80.806 0.750 re f 500.069 641.418 0.750 18.900 re f 580.125 641.418 0.750 18.900 re f 0.271 0.267 0.267 rg BT 505.319 647.898 Td /F1 9.8 Tf [(1-15)] TJ ET 0.267 0.267 0.267 rg 26.625 641.418 176.654 0.750 re f 26.625 603.468 0.750 38.700 re f 0.271 0.267 0.267 rg BT 31.875 629.748 Td /F1 9.8 Tf [(Multiple Metods )] TJ ET BT 31.875 619.848 Td /F1 9.8 Tf [(of Ascertainment)] TJ ET BT 31.875 609.948 Td /F1 9.8 Tf [(MMA)] TJ ET 0.267 0.267 0.267 rg 202.529 641.418 95.156 0.750 re f 202.529 603.468 0.750 38.700 re f 0.271 0.267 0.267 rg BT 207.779 629.748 Td /F1 9.8 Tf [(25)] TJ ET 0.267 0.267 0.267 rg 296.936 641.418 74.854 0.750 re f 296.936 603.468 0.750 38.700 re f 0.271 0.267 0.267 rg BT 302.186 629.748 Td /F1 9.8 Tf [(5.32)] TJ ET 0.267 0.267 0.267 rg 371.040 641.418 129.780 0.750 re f 371.040 603.468 0.750 38.700 re f 0.271 0.267 0.267 rg BT 376.290 629.748 Td /F1 9.8 Tf [(4.18-6.60)] TJ ET 0.267 0.267 0.267 rg 500.069 641.418 80.806 0.750 re f 500.069 603.468 0.750 38.700 re f 580.125 603.468 0.750 38.700 re f 0.271 0.267 0.267 rg BT 505.319 629.748 Td /F1 9.8 Tf [(1-15)] TJ ET 0.267 0.267 0.267 rg 26.625 603.468 176.654 0.750 re f 26.625 585.318 0.750 18.900 re f 0.271 0.267 0.267 rg BT 31.875 591.798 Td /F1 9.8 Tf [(MMA + High Income)] TJ ET 0.267 0.267 0.267 rg 202.529 603.468 95.156 0.750 re f 202.529 585.318 0.750 18.900 re f 0.271 0.267 0.267 rg BT 207.779 591.798 Td /F1 9.8 Tf [(22)] TJ ET 0.267 0.267 0.267 rg 296.936 603.468 74.854 0.750 re f 296.936 585.318 0.750 18.900 re f 0.271 0.267 0.267 rg BT 302.186 591.798 Td /F1 9.8 Tf [(4.70)] TJ ET 0.267 0.267 0.267 rg 371.040 603.468 129.780 0.750 re f 371.040 585.318 0.750 18.900 re f 0.271 0.267 0.267 rg BT 376.290 591.798 Td /F1 9.8 Tf [(3.71-5.80)] TJ ET 0.267 0.267 0.267 rg 500.069 603.468 80.806 0.750 re f 500.069 585.318 0.750 18.900 re f 580.125 585.318 0.750 18.900 re f 0.271 0.267 0.267 rg BT 505.319 591.798 Td /F1 9.8 Tf [(1-12)] TJ ET 0.267 0.267 0.267 rg 26.625 585.318 176.654 0.750 re f 26.625 557.268 0.750 28.800 re f 0.271 0.267 0.267 rg BT 31.875 573.648 Td /F1 9.8 Tf [(MMA + Upper)] TJ ET BT 31.875 563.748 Td /F1 9.8 Tf [(Middle Income)] TJ ET 0.267 0.267 0.267 rg 202.529 585.318 95.156 0.750 re f 202.529 557.268 0.750 28.800 re f 0.271 0.267 0.267 rg BT 207.779 573.648 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 296.936 585.318 74.854 0.750 re f 296.936 557.268 0.750 28.800 re f 0.271 0.267 0.267 rg BT 302.186 573.648 Td /F1 9.8 Tf [(9.95)] TJ ET 0.267 0.267 0.267 rg 371.040 585.318 129.780 0.750 re f 371.040 557.268 0.750 28.800 re f 0.271 0.267 0.267 rg BT 376.290 573.648 Td /F1 9.8 Tf [(6.37-14.22)] TJ ET 0.267 0.267 0.267 rg 500.069 585.318 80.806 0.750 re f 500.069 557.268 0.750 28.800 re f 580.125 557.268 0.750 28.800 re f 0.271 0.267 0.267 rg BT 505.319 573.648 Td /F1 9.8 Tf [(6-15)] TJ ET 0.267 0.267 0.267 rg 26.625 557.268 176.654 0.750 re f 26.625 529.218 0.750 28.800 re f 0.271 0.267 0.267 rg BT 31.875 545.598 Td /F1 9.8 Tf [(MMA + Post 1980 +)] TJ ET BT 31.875 535.698 Td /F1 9.8 Tf [(High Income)] TJ ET 0.267 0.267 0.267 rg 202.529 557.268 95.156 0.750 re f 202.529 529.218 0.750 28.800 re f 0.271 0.267 0.267 rg BT 207.779 545.598 Td /F1 9.8 Tf [(11)] TJ ET 0.267 0.267 0.267 rg 296.936 557.268 74.854 0.750 re f 296.936 529.218 0.750 28.800 re f 0.271 0.267 0.267 rg BT 302.186 545.598 Td /F1 9.8 Tf [(4.81)] TJ ET 0.267 0.267 0.267 rg 371.040 557.268 129.780 0.750 re f 371.040 529.218 0.750 28.800 re f 0.271 0.267 0.267 rg BT 376.290 545.598 Td /F1 9.8 Tf [(3.31-6.58)] TJ ET 0.267 0.267 0.267 rg 500.069 557.268 80.806 0.750 re f 500.069 529.218 0.750 28.800 re f 580.125 529.218 0.750 28.800 re f 0.271 0.267 0.267 rg BT 505.319 545.598 Td /F1 9.8 Tf [(1-10)] TJ ET 0.267 0.267 0.267 rg 26.625 529.218 176.654 0.750 re f 26.625 501.168 176.654 0.750 re f 26.625 501.168 0.750 28.800 re f 0.271 0.267 0.267 rg BT 31.875 517.548 Td /F1 9.8 Tf [(MMA + Post 1980 +)] TJ ET BT 31.875 507.648 Td /F1 9.8 Tf [(Upper Middle Income)] TJ ET 0.267 0.267 0.267 rg 202.529 529.218 95.156 0.750 re f 202.529 501.168 95.156 0.750 re f 202.529 501.168 0.750 28.800 re f 0.271 0.267 0.267 rg BT 207.779 517.548 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 296.936 529.218 74.854 0.750 re f 296.936 501.168 74.854 0.750 re f 296.936 501.168 0.750 28.800 re f 0.271 0.267 0.267 rg BT 302.186 517.548 Td /F1 9.8 Tf [(9.95)] TJ ET 0.267 0.267 0.267 rg 371.040 529.218 129.780 0.750 re f 371.040 501.168 129.780 0.750 re f 371.040 501.168 0.750 28.800 re f 0.271 0.267 0.267 rg BT 376.290 517.548 Td /F1 9.8 Tf [(6.37- 14.22)] TJ ET 0.267 0.267 0.267 rg 500.069 529.218 80.806 0.750 re f 500.069 501.168 80.806 0.750 re f 500.069 501.168 0.750 28.800 re f 580.125 501.168 0.750 28.800 re f 0.271 0.267 0.267 rg BT 505.319 517.548 Td /F1 9.8 Tf [(6-15)] TJ ET BT 26.250 450.938 Td /F1 9.8 Tf [(Data on childhood and adolescent onset cases was available for 42 studies, representing 475 cases. Of these, )] TJ ET BT 26.250 435.494 Td /F1 9.8 Tf [(111 \(23.4%\) and 364 \(76.6%\) were childhood and adolescent onset, respectively. Only seven studies found a )] TJ ET BT 26.250 420.050 Td /F1 9.8 Tf [(higher proportion of childhood onset cases, with two studies reporting equal numbers. Therefore in 76% of )] TJ ET BT 26.250 404.606 Td /F1 9.8 Tf [(studies, adolescent onset occurred more frequently than childhood onset. When we consider just the most )] TJ ET BT 26.250 389.162 Td /F1 9.8 Tf [(recent studies of the highest quality from the high income group \(the MMA-post 1980 studies\), the pattern is )] TJ ET BT 26.250 373.718 Td /F1 9.8 Tf [(similar with 40 out of 50 \(80%\) cases being of adolescent onset.)] TJ ET BT 26.250 332.923 Td /F4 12.0 Tf [(Discussion)] TJ ET BT 26.250 309.266 Td /F4 9.8 Tf [(Main results.)] TJ ET BT 97.883 309.266 Td /F1 9.8 Tf [( In the meta-analysis of all the studies identified in this review we estimate the proportion of JHD )] TJ ET BT 26.250 293.822 Td /F1 9.8 Tf [(cases to be 4.92% \(95% CI 4.07%  5.84%\). In order to expand on Hayden s original work)] TJ ET 0.267 0.267 0.267 rg BT 464.308 295.777 Td /F4 8.7 Tf [(11)] TJ ET 0.271 0.267 0.267 rg BT 476.372 293.822 Td /F1 9.8 Tf [( and produce more )] TJ ET BT 26.250 278.378 Td /F1 9.8 Tf [(robust estimates of the proportion of JHD cases, the potential sources of bias associated with the various )] TJ ET BT 26.250 262.934 Td /F1 9.8 Tf [(studies were considered. We identified 35 studies which were based on clinic lists or rosters \(Figure 2\); and 25 )] TJ ET BT 26.250 247.490 Td /F1 9.8 Tf [(studies which used multiple methods of ascertainment \(Figure 3\). These gave mean estimates of the proportion )] TJ ET BT 26.250 232.046 Td /F1 9.8 Tf [(of 4.94% and 5.32% respectively. A clinic list or roster approach may downwardly bias the proportion of JHD )] TJ ET BT 26.250 216.602 Td /F1 9.8 Tf [(cases if it is perceived that the clinic serves mainly adult patients. Studies with multiple methods of )] TJ ET BT 26.250 201.158 Td /F1 9.8 Tf [(ascertainment are more likely to give a robust estimate.)] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 18.032 Td /F5 11.0 Tf [(11)] TJ ET BT 25.000 18.032 Td /F5 11.0 Tf [(PLOS Currents Huntington Disease)] TJ ET Q endstream endobj 431 0 obj << /Type /Annot /Subtype /Link /A 432 0 R /Border [0 0 0] /H /I /Rect [ 464.3077 294.7370 476.3718 306.1770 ] >> endobj 432 0 obj << /Type /Action >> endobj 433 0 obj << /Type /Annot /Subtype /Link /A 434 0 R /Border [0 0 0] /H /I /Rect [ 464.3077 294.7370 476.3718 306.1770 ] >> endobj 434 0 obj << /Type /Action >> endobj 435 0 obj << /Type /Annot /Subtype /Link /A 436 0 R /Border [0 0 0] /H /I /Rect [ 464.3077 294.7370 476.3718 306.1770 ] >> endobj 436 0 obj << /Type /Action >> endobj 437 0 obj << /Type /Page /Parent 3 0 R /Annots [ 439 0 R 441 0 R 443 0 R 445 0 R 447 0 R 449 0 R 451 0 R 453 0 R 455 0 R 457 0 R 459 0 R 461 0 R 463 0 R 465 0 R 467 0 R 469 0 R 471 0 R 473 0 R 475 0 R 477 0 R 479 0 R 481 0 R 483 0 R 485 0 R ] /Contents 438 0 R >> endobj 438 0 obj << /Length 22065 >> stream 0.271 0.267 0.267 rg 0.267 0.267 0.267 RG q 15.000 258.060 577.500 518.940 re W n 0.271 0.267 0.267 rg BT 26.250 764.645 Td /F1 9.8 Tf [(Most studies were conducted in Europe and North America so the effect of considering geography was minimal )] TJ ET BT 26.250 749.201 Td /F1 9.8 Tf [(\(Figure 4\); however, the three studies from economically less developed countries \(Figure 5\) were effectively )] TJ ET BT 26.250 733.757 Td /F1 9.8 Tf [(from the South African black population and Venezuela. The longitudinal study of families from the area around )] TJ ET BT 26.250 718.313 Td /F1 9.8 Tf [(Lake Maricaibo has been important in that it contributed to the original localisation of the gene to chromosome )] TJ ET BT 26.250 702.869 Td /F1 9.8 Tf [(4 and for an understanding of the natural history of the condition )] TJ ET 0.267 0.267 0.267 rg BT 348.751 704.824 Td /F4 8.7 Tf [(10)] TJ ET BT 360.815 704.824 Td /F4 8.7 Tf [(44)] TJ ET BT 372.879 704.824 Td /F4 8.7 Tf [(80)] TJ ET 0.271 0.267 0.267 rg BT 384.943 702.869 Td /F1 9.8 Tf [( The mean proportion of JHD cases )] TJ ET BT 26.250 687.425 Td /F1 9.8 Tf [(from these three studies was 9.95% \(95% CI 6.57%  14.22%\). If the age of death was lower in the general )] TJ ET BT 26.250 671.981 Td /F1 9.8 Tf [(population in which these cases live, then those with HD who were destined to develop the condition later in life )] TJ ET BT 26.250 656.537 Td /F1 9.8 Tf [(may not manifest as they die of other causes; consequently the proportion of JHD cases will be higher. In )] TJ ET BT 26.250 641.093 Td /F1 9.8 Tf [(addition, the patients with HD living around Lake Maricaibo are a relatively closed community so it is possible )] TJ ET BT 26.250 625.649 Td /F1 9.8 Tf [(that this also has an effect on the proportion of JHD cases. These three studies were reported after 1980.)] TJ ET BT 26.250 602.705 Td /F1 9.8 Tf [(Eleven studies were reported after 1980, which used multiple methods of ascertainment, and were from )] TJ ET BT 26.250 587.261 Td /F1 9.8 Tf [(economically more developed countries; these gave a slightly lower proportion of 4.81% \(95% CI 3.31%  )] TJ ET BT 26.250 571.817 Td /F1 9.8 Tf [(6.58%\) and may be considered the most robust estimate to use when considering European and North )] TJ ET BT 26.250 556.373 Td /F1 9.8 Tf [(American populations.)] TJ ET BT 26.250 533.429 Td /F4 9.8 Tf [(Implications for Research.)] TJ ET BT 170.394 533.429 Td /F1 9.8 Tf [( At present, there is no treatment to alter the natural history of HD. As soon as )] TJ ET BT 26.250 517.985 Td /F1 9.8 Tf [(treatments become available which do alter the natural history of HD, then it will be important to assess their )] TJ ET BT 26.250 502.541 Td /F1 9.8 Tf [(effects on patients at the more extreme end of the phenotypic spectrum. If a faster rate of disease progression )] TJ ET BT 26.250 487.097 Td /F1 9.8 Tf [(can be demonstrated in this group of patients, then any compound which affects the natural history of HD may )] TJ ET BT 26.250 471.653 Td /F1 9.8 Tf [(show an effect more quickly.)] TJ ET BT 26.250 448.709 Td /F1 9.8 Tf [(In June 2010, the UK population was estimated to be 62.3 million)] TJ ET 0.267 0.267 0.267 rg BT 344.276 450.664 Td /F4 8.7 Tf [(79)] TJ ET 0.271 0.267 0.267 rg BT 356.340 448.709 Td /F1 9.8 Tf [( . If we assume the prevalence of HD is )] TJ ET BT 26.250 433.265 Td /F1 9.8 Tf [(approximately 4-10 per 100)] TJ ET 0.267 0.267 0.267 rg BT 163.062 435.220 Td /F4 8.7 Tf [(11)] TJ ET BT 175.126 435.220 Td /F4 8.7 Tf [(12)] TJ ET BT 187.190 435.220 Td /F4 8.7 Tf [(13)] TJ ET BT 199.254 435.220 Td /F4 8.7 Tf [(14)] TJ ET 0.271 0.267 0.267 rg BT 211.318 433.265 Td /F1 9.8 Tf [( , in the UK and we also assume some degree of under-ascertainment; )] TJ ET BT 26.250 417.821 Td /F1 9.8 Tf [(therefore, using a figure of 100 HD patients per million would imply that there are around 6,230 patients with )] TJ ET BT 26.250 402.377 Td /F1 9.8 Tf [(HD in the UK, so we should expect to see approximately 300 cases with an onset under the age of 20 years )] TJ ET BT 26.250 386.933 Td /F1 9.8 Tf [(\(95% CI 205  411\). Identifying these patients represents a considerable challenge.)] TJ ET BT 26.250 363.989 Td /F4 9.8 Tf [(Conclusion)] TJ ET BT 26.250 341.045 Td /F1 9.8 Tf [(We have presented a review of the proportion of cases with JHD from 62 studies. Using data from 25 studies )] TJ ET BT 26.250 325.601 Td /F1 9.8 Tf [(after 1980 which were mainly fromNorthern Europe suggests that the mean proportion of JHD cases is just less )] TJ ET BT 26.250 310.157 Td /F1 9.8 Tf [(than 5%.)] TJ ET BT 26.250 269.362 Td /F4 12.0 Tf [(APPENDIX 1)] TJ ET Q q 15.000 258.060 577.500 518.940 re W n 0.271 0.267 0.267 rg BT 26.250 764.645 Td /F1 9.8 Tf [(Most studies were conducted in Europe and North America so the effect of considering geography was minimal )] TJ ET BT 26.250 749.201 Td /F1 9.8 Tf [(\(Figure 4\); however, the three studies from economically less developed countries \(Figure 5\) were effectively )] TJ ET BT 26.250 733.757 Td /F1 9.8 Tf [(from the South African black population and Venezuela. The longitudinal study of families from the area around )] TJ ET BT 26.250 718.313 Td /F1 9.8 Tf [(Lake Maricaibo has been important in that it contributed to the original localisation of the gene to chromosome )] TJ ET BT 26.250 702.869 Td /F1 9.8 Tf [(4 and for an understanding of the natural history of the condition )] TJ ET 0.267 0.267 0.267 rg BT 348.751 704.824 Td /F4 8.7 Tf [(10)] TJ ET BT 360.815 704.824 Td /F4 8.7 Tf [(44)] TJ ET BT 372.879 704.824 Td /F4 8.7 Tf [(80)] TJ ET 0.271 0.267 0.267 rg BT 384.943 702.869 Td /F1 9.8 Tf [( The mean proportion of JHD cases )] TJ ET BT 26.250 687.425 Td /F1 9.8 Tf [(from these three studies was 9.95% \(95% CI 6.57%  14.22%\). If the age of death was lower in the general )] TJ ET BT 26.250 671.981 Td /F1 9.8 Tf [(population in which these cases live, then those with HD who were destined to develop the condition later in life )] TJ ET BT 26.250 656.537 Td /F1 9.8 Tf [(may not manifest as they die of other causes; consequently the proportion of JHD cases will be higher. In )] TJ ET BT 26.250 641.093 Td /F1 9.8 Tf [(addition, the patients with HD living around Lake Maricaibo are a relatively closed community so it is possible )] TJ ET BT 26.250 625.649 Td /F1 9.8 Tf [(that this also has an effect on the proportion of JHD cases. These three studies were reported after 1980.)] TJ ET BT 26.250 602.705 Td /F1 9.8 Tf [(Eleven studies were reported after 1980, which used multiple methods of ascertainment, and were from )] TJ ET BT 26.250 587.261 Td /F1 9.8 Tf [(economically more developed countries; these gave a slightly lower proportion of 4.81% \(95% CI 3.31%  )] TJ ET BT 26.250 571.817 Td /F1 9.8 Tf [(6.58%\) and may be considered the most robust estimate to use when considering European and North )] TJ ET BT 26.250 556.373 Td /F1 9.8 Tf [(American populations.)] TJ ET BT 26.250 533.429 Td /F4 9.8 Tf [(Implications for Research.)] TJ ET BT 170.394 533.429 Td /F1 9.8 Tf [( At present, there is no treatment to alter the natural history of HD. As soon as )] TJ ET BT 26.250 517.985 Td /F1 9.8 Tf [(treatments become available which do alter the natural history of HD, then it will be important to assess their )] TJ ET BT 26.250 502.541 Td /F1 9.8 Tf [(effects on patients at the more extreme end of the phenotypic spectrum. If a faster rate of disease progression )] TJ ET BT 26.250 487.097 Td /F1 9.8 Tf [(can be demonstrated in this group of patients, then any compound which affects the natural history of HD may )] TJ ET BT 26.250 471.653 Td /F1 9.8 Tf [(show an effect more quickly.)] TJ ET BT 26.250 448.709 Td /F1 9.8 Tf [(In June 2010, the UK population was estimated to be 62.3 million)] TJ ET 0.267 0.267 0.267 rg BT 344.276 450.664 Td /F4 8.7 Tf [(79)] TJ ET 0.271 0.267 0.267 rg BT 356.340 448.709 Td /F1 9.8 Tf [( . If we assume the prevalence of HD is )] TJ ET BT 26.250 433.265 Td /F1 9.8 Tf [(approximately 4-10 per 100)] TJ ET 0.267 0.267 0.267 rg BT 163.062 435.220 Td /F4 8.7 Tf [(11)] TJ ET BT 175.126 435.220 Td /F4 8.7 Tf [(12)] TJ ET BT 187.190 435.220 Td /F4 8.7 Tf [(13)] TJ ET BT 199.254 435.220 Td /F4 8.7 Tf [(14)] TJ ET 0.271 0.267 0.267 rg BT 211.318 433.265 Td /F1 9.8 Tf [( , in the UK and we also assume some degree of under-ascertainment; )] TJ ET BT 26.250 417.821 Td /F1 9.8 Tf [(therefore, using a figure of 100 HD patients per million would imply that there are around 6,230 patients with )] TJ ET BT 26.250 402.377 Td /F1 9.8 Tf [(HD in the UK, so we should expect to see approximately 300 cases with an onset under the age of 20 years )] TJ ET BT 26.250 386.933 Td /F1 9.8 Tf [(\(95% CI 205  411\). Identifying these patients represents a considerable challenge.)] TJ ET BT 26.250 363.989 Td /F4 9.8 Tf [(Conclusion)] TJ ET BT 26.250 341.045 Td /F1 9.8 Tf [(We have presented a review of the proportion of cases with JHD from 62 studies. Using data from 25 studies )] TJ ET BT 26.250 325.601 Td /F1 9.8 Tf [(after 1980 which were mainly fromNorthern Europe suggests that the mean proportion of JHD cases is just less )] TJ ET BT 26.250 310.157 Td /F1 9.8 Tf [(than 5%.)] TJ ET BT 26.250 269.362 Td /F4 12.0 Tf [(APPENDIX 1)] TJ ET Q q 15.000 258.060 577.500 518.940 re W n 0.271 0.267 0.267 rg BT 26.250 764.645 Td /F1 9.8 Tf [(Most studies were conducted in Europe and North America so the effect of considering geography was minimal )] TJ ET BT 26.250 749.201 Td /F1 9.8 Tf [(\(Figure 4\); however, the three studies from economically less developed countries \(Figure 5\) were effectively )] TJ ET BT 26.250 733.757 Td /F1 9.8 Tf [(from the South African black population and Venezuela. The longitudinal study of families from the area around )] TJ ET BT 26.250 718.313 Td /F1 9.8 Tf [(Lake Maricaibo has been important in that it contributed to the original localisation of the gene to chromosome )] TJ ET BT 26.250 702.869 Td /F1 9.8 Tf [(4 and for an understanding of the natural history of the condition )] TJ ET 0.267 0.267 0.267 rg BT 348.751 704.824 Td /F4 8.7 Tf [(10)] TJ ET BT 360.815 704.824 Td /F4 8.7 Tf [(44)] TJ ET BT 372.879 704.824 Td /F4 8.7 Tf [(80)] TJ ET 0.271 0.267 0.267 rg BT 384.943 702.869 Td /F1 9.8 Tf [( The mean proportion of JHD cases )] TJ ET BT 26.250 687.425 Td /F1 9.8 Tf [(from these three studies was 9.95% \(95% CI 6.57%  14.22%\). If the age of death was lower in the general )] TJ ET BT 26.250 671.981 Td /F1 9.8 Tf [(population in which these cases live, then those with HD who were destined to develop the condition later in life )] TJ ET BT 26.250 656.537 Td /F1 9.8 Tf [(may not manifest as they die of other causes; consequently the proportion of JHD cases will be higher. In )] TJ ET BT 26.250 641.093 Td /F1 9.8 Tf [(addition, the patients with HD living around Lake Maricaibo are a relatively closed community so it is possible )] TJ ET BT 26.250 625.649 Td /F1 9.8 Tf [(that this also has an effect on the proportion of JHD cases. These three studies were reported after 1980.)] TJ ET BT 26.250 602.705 Td /F1 9.8 Tf [(Eleven studies were reported after 1980, which used multiple methods of ascertainment, and were from )] TJ ET BT 26.250 587.261 Td /F1 9.8 Tf [(economically more developed countries; these gave a slightly lower proportion of 4.81% \(95% CI 3.31%  )] TJ ET BT 26.250 571.817 Td /F1 9.8 Tf [(6.58%\) and may be considered the most robust estimate to use when considering European and North )] TJ ET BT 26.250 556.373 Td /F1 9.8 Tf [(American populations.)] TJ ET BT 26.250 533.429 Td /F4 9.8 Tf [(Implications for Research.)] TJ ET BT 170.394 533.429 Td /F1 9.8 Tf [( At present, there is no treatment to alter the natural history of HD. As soon as )] TJ ET BT 26.250 517.985 Td /F1 9.8 Tf [(treatments become available which do alter the natural history of HD, then it will be important to assess their )] TJ ET BT 26.250 502.541 Td /F1 9.8 Tf [(effects on patients at the more extreme end of the phenotypic spectrum. If a faster rate of disease progression )] TJ ET BT 26.250 487.097 Td /F1 9.8 Tf [(can be demonstrated in this group of patients, then any compound which affects the natural history of HD may )] TJ ET BT 26.250 471.653 Td /F1 9.8 Tf [(show an effect more quickly.)] TJ ET BT 26.250 448.709 Td /F1 9.8 Tf [(In June 2010, the UK population was estimated to be 62.3 million)] TJ ET 0.267 0.267 0.267 rg BT 344.276 450.664 Td /F4 8.7 Tf [(79)] TJ ET 0.271 0.267 0.267 rg BT 356.340 448.709 Td /F1 9.8 Tf [( . If we assume the prevalence of HD is )] TJ ET BT 26.250 433.265 Td /F1 9.8 Tf [(approximately 4-10 per 100)] TJ ET 0.267 0.267 0.267 rg BT 163.062 435.220 Td /F4 8.7 Tf [(11)] TJ ET BT 175.126 435.220 Td /F4 8.7 Tf [(12)] TJ ET BT 187.190 435.220 Td /F4 8.7 Tf [(13)] TJ ET BT 199.254 435.220 Td /F4 8.7 Tf [(14)] TJ ET 0.271 0.267 0.267 rg BT 211.318 433.265 Td /F1 9.8 Tf [( , in the UK and we also assume some degree of under-ascertainment; )] TJ ET BT 26.250 417.821 Td /F1 9.8 Tf [(therefore, using a figure of 100 HD patients per million would imply that there are around 6,230 patients with )] TJ ET BT 26.250 402.377 Td /F1 9.8 Tf [(HD in the UK, so we should expect to see approximately 300 cases with an onset under the age of 20 years )] TJ ET BT 26.250 386.933 Td /F1 9.8 Tf [(\(95% CI 205  411\). Identifying these patients represents a considerable challenge.)] TJ ET BT 26.250 363.989 Td /F4 9.8 Tf [(Conclusion)] TJ ET BT 26.250 341.045 Td /F1 9.8 Tf [(We have presented a review of the proportion of cases with JHD from 62 studies. Using data from 25 studies )] TJ ET BT 26.250 325.601 Td /F1 9.8 Tf [(after 1980 which were mainly fromNorthern Europe suggests that the mean proportion of JHD cases is just less )] TJ ET BT 26.250 310.157 Td /F1 9.8 Tf [(than 5%.)] TJ ET BT 26.250 269.362 Td /F4 12.0 Tf [(APPENDIX 1)] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 18.032 Td /F5 11.0 Tf [(12)] TJ ET BT 25.000 18.032 Td /F5 11.0 Tf [(PLOS Currents Huntington Disease)] TJ ET Q endstream endobj 439 0 obj << /Type /Annot /Subtype /Link /A 440 0 R /Border [0 0 0] /H /I /Rect [ 348.7507 703.7840 360.8148 715.2240 ] >> endobj 440 0 obj << /Type /Action >> endobj 441 0 obj << /Type /Annot /Subtype /Link /A 442 0 R /Border [0 0 0] /H /I /Rect [ 360.8148 703.7840 372.8788 715.2240 ] >> endobj 442 0 obj << /Type /Action >> endobj 443 0 obj << /Type /Annot /Subtype /Link /A 444 0 R /Border [0 0 0] /H /I /Rect [ 372.8788 703.7840 384.9428 715.2240 ] >> endobj 444 0 obj << /Type /Action >> endobj 445 0 obj << /Type /Annot /Subtype /Link 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R 607 0 R ] /Contents 488 0 R >> endobj 488 0 obj << /Length 125808 >> stream 0.271 0.267 0.267 rg q 15.000 95.247 577.500 681.753 re W n q 26.250 759.180 555.000 17.820 re W n 0.271 0.267 0.267 rg BT 26.250 762.744 Td /F1 9.8 Tf [(Summary of all studies used in this analysis)] TJ ET Q 0.965 0.965 0.965 rg 26.250 712.086 555.000 39.594 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 751.680 m 581.250 751.680 l 580.500 750.930 l 27.000 750.930 l f 581.250 751.680 m 581.250 712.086 l 580.500 712.086 l 580.500 750.930 l f 26.250 751.680 m 26.250 712.086 l 27.000 712.086 l 27.000 750.930 l f 0.271 0.267 0.267 rg BT 33.000 734.792 Td /F1 9.0 Tf [(* refers to studies included in the original Hayden study)] TJ ET 0.267 0.267 0.267 rg BT 285.477 735.330 Td /F4 8.0 Tf [(11)] TJ ET 0.271 0.267 0.267 rg BT 296.613 734.792 Td /F1 9.0 Tf [( The paper from Pleydell 1954)] TJ ET 0.267 0.267 0.267 rg BT 435.789 735.330 Td /F4 8.0 Tf [(26)] TJ ET 0.271 0.267 0.267 rg BT 446.925 734.792 Td /F1 9.0 Tf [(was included with )] TJ ET BT 33.000 722.120 Td /F1 9.0 Tf [(additional data from Pleydell 1955)] TJ ET 0.267 0.267 0.267 rg BT 188.520 722.658 Td /F4 8.0 Tf [(27)] TJ ET 0.271 0.267 0.267 rg BT 199.656 722.120 Td /F1 9.0 Tf [( - means there was no furher specification of age)] TJ ET 1.000 1.000 1.000 rg 26.250 95.247 555.000 616.839 re f 0.965 0.965 0.965 rg 27.000 680.073 81.234 31.263 re f 0.267 0.267 0.267 rg 26.625 710.961 81.609 0.750 re f 26.625 679.698 0.750 32.013 re f 0.271 0.267 0.267 rg BT 31.500 698.981 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 108.234 680.073 70.068 31.263 re f 0.267 0.267 0.267 rg 108.234 710.961 70.068 0.750 re f 0.271 0.267 0.267 rg BT 112.734 698.981 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 178.302 680.073 79.835 31.263 re f 0.267 0.267 0.267 rg 178.302 710.961 79.835 0.750 re f 0.271 0.267 0.267 rg BT 182.802 698.981 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 258.136 680.073 46.292 31.263 re f 0.267 0.267 0.267 rg 258.136 710.961 46.292 0.750 re f 0.271 0.267 0.267 rg BT 262.636 698.981 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 304.428 680.073 56.616 31.263 re f 0.267 0.267 0.267 rg 304.428 710.961 56.616 0.750 re f 0.271 0.267 0.267 rg BT 308.928 698.981 Td /F4 9.8 Tf [(0 -10 )] TJ ET BT 308.928 683.537 Td /F4 9.8 Tf [(years)] TJ ET 0.965 0.965 0.965 rg 361.044 680.073 31.314 31.263 re f 0.267 0.267 0.267 rg 361.044 710.961 31.314 0.750 re f 0.271 0.267 0.267 rg BT 365.544 698.981 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 392.358 680.073 56.616 31.263 re f 0.267 0.267 0.267 rg 392.358 710.961 56.616 0.750 re f 0.271 0.267 0.267 rg BT 396.858 698.981 Td /F4 9.8 Tf [(11-20 )] TJ ET BT 396.858 683.537 Td /F4 9.8 Tf [(years)] TJ ET 0.965 0.965 0.965 rg 448.973 680.073 38.162 31.263 re f 0.267 0.267 0.267 rg 448.973 710.961 38.162 0.750 re f 0.271 0.267 0.267 rg BT 453.473 698.981 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 487.135 680.073 55.203 31.263 re f 0.267 0.267 0.267 rg 487.135 710.961 55.203 0.750 re f 0.271 0.267 0.267 rg BT 491.635 698.981 Td /F4 9.8 Tf [(Total )] TJ ET BT 491.635 683.537 Td /F4 9.8 Tf [(JHD)] TJ ET 0.965 0.965 0.965 rg 542.338 680.073 38.162 31.263 re f 0.267 0.267 0.267 rg 542.338 710.961 38.537 0.750 re f 580.125 679.698 0.750 32.013 re f 0.271 0.267 0.267 rg BT 546.838 698.981 Td /F4 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 26.625 679.698 81.984 0.750 re f 26.625 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 31.875 668.028 Td /F1 9.8 Tf [(Authors)] TJ ET 0.267 0.267 0.267 rg 107.859 679.698 70.818 0.750 re f 107.859 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 113.109 668.028 Td /F1 9.8 Tf [(Publication)] TJ ET BT 113.109 658.128 Td /F1 9.8 Tf [(year)] TJ ET 0.267 0.267 0.267 rg 177.927 679.698 80.585 0.750 re f 177.927 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 183.177 668.028 Td /F1 9.8 Tf [(Location)] TJ ET 0.267 0.267 0.267 rg 257.761 679.698 47.042 0.750 re f 257.761 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 263.011 668.028 Td /F1 9.8 Tf [(Total )] TJ ET BT 263.011 658.128 Td /F1 9.8 Tf [(HD )] TJ ET BT 263.011 648.228 Td /F1 9.8 Tf [(cases)] TJ ET 0.267 0.267 0.267 rg 304.053 679.698 57.366 0.750 re f 304.053 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 309.303 668.028 Td /F1 9.8 Tf [(Number)] TJ ET 0.267 0.267 0.267 rg 360.669 679.698 32.064 0.750 re f 360.669 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 365.919 668.028 Td /F1 9.8 Tf [(%)] TJ ET 0.267 0.267 0.267 rg 391.983 679.698 57.366 0.750 re f 391.983 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 397.233 668.028 Td /F1 9.8 Tf [(Number)] TJ ET 0.267 0.267 0.267 rg 448.598 679.698 38.912 0.750 re f 448.598 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 453.848 668.028 Td /F1 9.8 Tf [(%)] TJ ET 0.267 0.267 0.267 rg 486.760 679.698 55.953 0.750 re f 486.760 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 492.010 668.028 Td /F1 9.8 Tf [(Number)] TJ ET 0.267 0.267 0.267 rg 541.963 679.698 38.912 0.750 re f 541.963 641.748 0.750 38.700 re f 580.125 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 547.213 668.028 Td /F1 9.8 Tf [(%)] TJ ET 0.267 0.267 0.267 rg 26.625 641.748 81.984 0.750 re f 26.625 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 630.078 Td /F1 9.8 Tf [(*Davenport )] TJ ET BT 31.875 617.116 Td /F1 9.8 Tf [(& Muncey)] TJ ET 0.267 0.267 0.267 rg BT 80.489 617.698 Td /F4 8.7 Tf [(29)] TJ ET 0.271 0.267 0.267 rg BT 92.553 617.116 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 641.748 70.818 0.750 re f 107.859 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 630.078 Td /F1 9.8 Tf [(1916)] TJ ET 0.267 0.267 0.267 rg 177.927 641.748 80.585 0.750 re f 177.927 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 630.078 Td /F1 9.8 Tf [(USA)] TJ ET 0.267 0.267 0.267 rg 257.761 641.748 47.042 0.750 re f 257.761 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 630.078 Td /F1 9.8 Tf [(138)] TJ ET 0.267 0.267 0.267 rg 304.053 641.748 57.366 0.750 re f 304.053 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 630.078 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 360.669 641.748 32.064 0.750 re f 360.669 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 630.078 Td /F1 9.8 Tf [(2.2)] TJ ET 0.267 0.267 0.267 rg 391.983 641.748 57.366 0.750 re f 391.983 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 630.078 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 448.598 641.748 38.912 0.750 re f 448.598 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 630.078 Td /F1 9.8 Tf [(1.4)] TJ ET 0.267 0.267 0.267 rg 486.760 641.748 55.953 0.750 re f 486.760 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 630.078 Td /F1 9.8 Tf [(5)] TJ ET 0.267 0.267 0.267 rg 541.963 641.748 38.912 0.750 re f 541.963 609.870 0.750 32.628 re f 580.125 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 630.078 Td /F1 9.8 Tf [(3.6)] TJ ET 0.267 0.267 0.267 rg 26.625 609.870 81.984 0.750 re f 26.625 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 598.200 Td /F1 9.8 Tf [(*Spillane &)] TJ ET BT 31.875 585.238 Td /F1 9.8 Tf [(Phillips)] TJ ET 0.267 0.267 0.267 rg BT 66.049 585.820 Td /F4 8.7 Tf [(30)] TJ ET 0.271 0.267 0.267 rg BT 78.113 585.238 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 609.870 70.818 0.750 re f 107.859 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 598.200 Td /F1 9.8 Tf [(1937)] TJ ET 0.267 0.267 0.267 rg 177.927 609.870 80.585 0.750 re f 177.927 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 598.200 Td /F1 9.8 Tf [(South )] TJ ET BT 183.177 588.300 Td /F1 9.8 Tf [(Wales)] TJ ET 0.267 0.267 0.267 rg 257.761 609.870 47.042 0.750 re f 257.761 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 598.200 Td /F1 9.8 Tf [(21)] TJ ET 0.267 0.267 0.267 rg 304.053 609.870 57.366 0.750 re f 304.053 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 598.200 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 609.870 32.064 0.750 re f 360.669 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 598.200 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 609.870 57.366 0.750 re f 391.983 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 598.200 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 448.598 609.870 38.912 0.750 re f 448.598 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 598.200 Td /F1 9.8 Tf [(9.5)] TJ ET 0.267 0.267 0.267 rg 486.760 609.870 55.953 0.750 re f 486.760 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 598.200 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 541.963 609.870 38.912 0.750 re f 541.963 577.992 0.750 32.628 re f 580.125 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 598.200 Td /F1 9.8 Tf [(9.5)] TJ ET 0.267 0.267 0.267 rg 26.625 577.992 81.984 0.750 re f 26.625 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 563.260 Td /F1 9.8 Tf [(*Panse)] TJ ET 0.267 0.267 0.267 rg BT 68.964 563.842 Td /F4 8.7 Tf [(20)] TJ ET 0.271 0.267 0.267 rg BT 81.028 563.260 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 577.992 70.818 0.750 re f 107.859 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 566.322 Td /F1 9.8 Tf [(1942)] TJ ET 0.267 0.267 0.267 rg 177.927 577.992 80.585 0.750 re f 177.927 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 566.322 Td /F1 9.8 Tf [(Germany)] TJ ET 0.267 0.267 0.267 rg 257.761 577.992 47.042 0.750 re f 257.761 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 566.322 Td /F1 9.8 Tf [(446)] TJ ET 0.267 0.267 0.267 rg 304.053 577.992 57.366 0.750 re f 304.053 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 566.322 Td /F1 9.8 Tf [(7)] TJ ET 0.267 0.267 0.267 rg 360.669 577.992 32.064 0.750 re f 360.669 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 566.322 Td /F1 9.8 Tf [(1.6)] TJ ET 0.267 0.267 0.267 rg 391.983 577.992 57.366 0.750 re f 391.983 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 566.322 Td /F1 9.8 Tf [(17)] TJ ET 0.267 0.267 0.267 rg 448.598 577.992 38.912 0.750 re f 448.598 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 566.322 Td /F1 9.8 Tf [(3.8)] TJ ET 0.267 0.267 0.267 rg 486.760 577.992 55.953 0.750 re f 486.760 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 566.322 Td /F1 9.8 Tf [(24)] TJ ET 0.267 0.267 0.267 rg 541.963 577.992 38.912 0.750 re f 541.963 556.014 0.750 22.728 re f 580.125 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 566.322 Td /F1 9.8 Tf [(5.4)] TJ ET 0.267 0.267 0.267 rg 26.625 556.014 81.984 0.750 re f 26.625 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 541.282 Td /F1 9.8 Tf [(Pleydell)] TJ ET 0.267 0.267 0.267 rg BT 72.942 541.864 Td /F4 8.7 Tf [(26)] TJ ET 0.271 0.267 0.267 rg BT 85.006 541.282 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 556.014 70.818 0.750 re f 107.859 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 544.344 Td /F1 9.8 Tf [(1954)] TJ ET 0.267 0.267 0.267 rg 177.927 556.014 80.585 0.750 re f 177.927 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 544.344 Td /F1 9.8 Tf [(England)] TJ ET 0.267 0.267 0.267 rg 257.761 556.014 47.042 0.750 re f 257.761 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 544.344 Td /F1 9.8 Tf [(17)] TJ ET 0.267 0.267 0.267 rg 304.053 556.014 57.366 0.750 re f 304.053 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 544.344 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 556.014 32.064 0.750 re f 360.669 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 544.344 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 556.014 57.366 0.750 re f 391.983 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 544.344 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 448.598 556.014 38.912 0.750 re f 448.598 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 544.344 Td /F1 9.8 Tf [(11.8)] TJ ET 0.267 0.267 0.267 rg 486.760 556.014 55.953 0.750 re f 486.760 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 544.344 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 541.963 556.014 38.912 0.750 re f 541.963 534.036 0.750 22.728 re f 580.125 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 544.344 Td /F1 9.8 Tf [(11.8)] TJ ET 0.267 0.267 0.267 rg 26.625 534.036 81.984 0.750 re f 26.625 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 522.366 Td /F1 9.8 Tf [(*Reed )] TJ ET BT 31.875 509.404 Td /F1 9.8 Tf [(et al)] TJ ET 0.267 0.267 0.267 rg BT 53.481 509.986 Td /F4 8.7 Tf [(18)] TJ ET 0.271 0.267 0.267 rg BT 65.545 509.404 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 534.036 70.818 0.750 re f 107.859 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 522.366 Td /F1 9.8 Tf [(1958)] TJ ET 0.267 0.267 0.267 rg 177.927 534.036 80.585 0.750 re f 177.927 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 522.366 Td /F1 9.8 Tf [(USA)] TJ ET 0.267 0.267 0.267 rg 257.761 534.036 47.042 0.750 re f 257.761 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 522.366 Td /F1 9.8 Tf [(203)] TJ ET 0.267 0.267 0.267 rg 304.053 534.036 57.366 0.750 re f 304.053 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 522.366 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 534.036 32.064 0.750 re f 360.669 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 522.366 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 534.036 57.366 0.750 re f 391.983 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 522.366 Td /F1 9.8 Tf [(12)] TJ ET 0.267 0.267 0.267 rg 448.598 534.036 38.912 0.750 re f 448.598 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 522.366 Td /F1 9.8 Tf [(5.9)] TJ ET 0.267 0.267 0.267 rg 486.760 534.036 55.953 0.750 re f 486.760 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 522.366 Td /F1 9.8 Tf [(12)] TJ ET 0.267 0.267 0.267 rg 541.963 534.036 38.912 0.750 re f 541.963 502.158 0.750 32.628 re f 580.125 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 522.366 Td /F1 9.8 Tf [(5.9)] TJ ET 0.267 0.267 0.267 rg 26.625 502.158 81.984 0.750 re f 26.625 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 487.426 Td /F1 9.8 Tf [(*Brothers)] TJ ET 0.267 0.267 0.267 rg BT 78.499 488.008 Td /F4 8.7 Tf [(31)] TJ ET 0.271 0.267 0.267 rg BT 90.564 487.426 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 502.158 70.818 0.750 re f 107.859 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 490.488 Td /F1 9.8 Tf [(1964)] TJ ET 0.267 0.267 0.267 rg 177.927 502.158 80.585 0.750 re f 177.927 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 490.488 Td /F1 9.8 Tf [(Australia)] TJ ET 0.267 0.267 0.267 rg 257.761 502.158 47.042 0.750 re f 257.761 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 490.488 Td /F1 9.8 Tf [(206)] TJ ET 0.267 0.267 0.267 rg 304.053 502.158 57.366 0.750 re f 304.053 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 490.488 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 360.669 502.158 32.064 0.750 re f 360.669 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 490.488 Td /F1 9.8 Tf [(1.9)] TJ ET 0.267 0.267 0.267 rg 391.983 502.158 57.366 0.750 re f 391.983 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 490.488 Td /F1 9.8 Tf [(11)] TJ ET 0.267 0.267 0.267 rg 448.598 502.158 38.912 0.750 re f 448.598 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 490.488 Td /F1 9.8 Tf [(5.3)] TJ ET 0.267 0.267 0.267 rg 486.760 502.158 55.953 0.750 re f 486.760 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 490.488 Td /F1 9.8 Tf [(15)] TJ ET 0.267 0.267 0.267 rg 541.963 502.158 38.912 0.750 re f 541.963 480.180 0.750 22.728 re f 580.125 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 490.488 Td /F1 9.8 Tf [(7.3)] TJ ET 0.267 0.267 0.267 rg 26.625 480.180 81.984 0.750 re f 26.625 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 468.510 Td /F1 9.8 Tf [(*Cameron )] TJ ET BT 31.875 455.548 Td /F1 9.8 Tf [(& Venters)] TJ ET 0.267 0.267 0.267 rg BT 80.333 456.130 Td /F4 8.7 Tf [(24)] TJ ET 0.271 0.267 0.267 rg BT 92.397 455.548 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 480.180 70.818 0.750 re f 107.859 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 468.510 Td /F1 9.8 Tf [(1967)] TJ ET 0.267 0.267 0.267 rg 177.927 480.180 80.585 0.750 re f 177.927 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 468.510 Td /F1 9.8 Tf [(Scotland)] TJ ET 0.267 0.267 0.267 rg 257.761 480.180 47.042 0.750 re f 257.761 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 468.510 Td /F1 9.8 Tf [(143)] TJ ET 0.267 0.267 0.267 rg 304.053 480.180 57.366 0.750 re f 304.053 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 468.510 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 480.180 32.064 0.750 re f 360.669 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 468.510 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 480.180 57.366 0.750 re f 391.983 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 468.510 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 480.180 38.912 0.750 re f 448.598 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 468.510 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 480.180 55.953 0.750 re f 486.760 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 468.510 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 541.963 480.180 38.912 0.750 re f 541.963 448.302 0.750 32.628 re f 580.125 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 468.510 Td /F1 9.8 Tf [(21)] TJ ET 0.267 0.267 0.267 rg 26.625 448.302 81.984 0.750 re f 26.625 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 433.570 Td /F1 9.8 Tf [(*Heathfield)] TJ ET 0.267 0.267 0.267 rg BT 90.200 434.152 Td /F4 8.7 Tf [(32)] TJ ET 0.271 0.267 0.267 rg BT 31.875 422.904 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 448.302 70.818 0.750 re f 107.859 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 436.632 Td /F1 9.8 Tf [(1967)] TJ ET 0.267 0.267 0.267 rg 177.927 448.302 80.585 0.750 re f 177.927 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 436.632 Td /F1 9.8 Tf [(England)] TJ ET 0.267 0.267 0.267 rg 257.761 448.302 47.042 0.750 re f 257.761 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 436.632 Td /F1 9.8 Tf [(81)] TJ ET 0.267 0.267 0.267 rg 304.053 448.302 57.366 0.750 re f 304.053 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 436.632 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 448.302 32.064 0.750 re f 360.669 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 436.632 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 448.302 57.366 0.750 re f 391.983 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 436.632 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 448.598 448.302 38.912 0.750 re f 448.598 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 436.632 Td /F1 9.8 Tf [(2.5)] TJ ET 0.267 0.267 0.267 rg 486.760 448.302 55.953 0.750 re f 486.760 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 436.632 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 541.963 448.302 38.912 0.750 re f 541.963 416.424 0.750 32.628 re f 580.125 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 436.632 Td /F1 9.8 Tf [(2.5)] TJ ET 0.267 0.267 0.267 rg 26.625 416.424 81.984 0.750 re f 26.625 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 401.692 Td /F1 9.8 Tf [(*Oliver)] TJ ET 0.267 0.267 0.267 rg BT 65.620 402.274 Td /F4 8.7 Tf [(33)] TJ ET 0.271 0.267 0.267 rg BT 77.684 401.692 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 416.424 70.818 0.750 re f 107.859 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 404.754 Td /F1 9.8 Tf [(1970)] TJ ET 0.267 0.267 0.267 rg 177.927 416.424 80.585 0.750 re f 177.927 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 404.754 Td /F1 9.8 Tf [(England)] TJ ET 0.267 0.267 0.267 rg 257.761 416.424 47.042 0.750 re f 257.761 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 404.754 Td /F1 9.8 Tf [(115)] TJ ET 0.267 0.267 0.267 rg 304.053 416.424 57.366 0.750 re f 304.053 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 404.754 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 360.669 416.424 32.064 0.750 re f 360.669 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 404.754 Td /F1 9.8 Tf [(3.5)] TJ ET 0.267 0.267 0.267 rg 391.983 416.424 57.366 0.750 re f 391.983 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 404.754 Td /F1 9.8 Tf [(7)] TJ ET 0.267 0.267 0.267 rg 448.598 416.424 38.912 0.750 re f 448.598 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 404.754 Td /F1 9.8 Tf [(6.1)] TJ ET 0.267 0.267 0.267 rg 486.760 416.424 55.953 0.750 re f 486.760 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 404.754 Td /F1 9.8 Tf [(11)] TJ ET 0.267 0.267 0.267 rg 541.963 416.424 38.912 0.750 re f 541.963 394.446 0.750 22.728 re f 580.125 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 404.754 Td /F1 9.8 Tf [(9.6)] TJ ET 0.267 0.267 0.267 rg 26.625 394.446 81.984 0.750 re f 26.625 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 379.714 Td /F1 9.8 Tf [(*Mattsson)] TJ ET 0.267 0.267 0.267 rg BT 84.194 380.296 Td /F4 8.7 Tf [(34)] TJ ET 0.271 0.267 0.267 rg BT 96.258 379.714 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 394.446 70.818 0.750 re f 107.859 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 382.776 Td /F1 9.8 Tf [(1974)] TJ ET 0.267 0.267 0.267 rg 177.927 394.446 80.585 0.750 re f 177.927 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 382.776 Td /F1 9.8 Tf [(Sweden)] TJ ET 0.267 0.267 0.267 rg 257.761 394.446 47.042 0.750 re f 257.761 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 382.776 Td /F1 9.8 Tf [(362)] TJ ET 0.267 0.267 0.267 rg 304.053 394.446 57.366 0.750 re f 304.053 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 382.776 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 394.446 32.064 0.750 re f 360.669 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 382.776 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 394.446 57.366 0.750 re f 391.983 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 382.776 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 394.446 38.912 0.750 re f 448.598 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 382.776 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 394.446 55.953 0.750 re f 486.760 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 382.776 Td /F1 9.8 Tf [(17)] TJ ET 0.267 0.267 0.267 rg 541.963 394.446 38.912 0.750 re f 541.963 372.468 0.750 22.728 re f 580.125 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 382.776 Td /F1 9.8 Tf [(4.7)] TJ ET 0.267 0.267 0.267 rg 26.625 372.468 81.984 0.750 re f 26.625 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 357.736 Td /F1 9.8 Tf [(*Stevens)] TJ ET 0.267 0.267 0.267 rg BT 78.889 358.318 Td /F4 8.7 Tf [(35)] TJ ET 0.271 0.267 0.267 rg BT 90.954 357.736 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 372.468 70.818 0.750 re f 107.859 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 360.798 Td /F1 9.8 Tf [(1976)] TJ ET 0.267 0.267 0.267 rg 177.927 372.468 80.585 0.750 re f 177.927 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 360.798 Td /F1 9.8 Tf [(England)] TJ ET 0.267 0.267 0.267 rg 257.761 372.468 47.042 0.750 re f 257.761 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 360.798 Td /F1 9.8 Tf [(133)] TJ ET 0.267 0.267 0.267 rg 304.053 372.468 57.366 0.750 re f 304.053 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 360.798 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 372.468 32.064 0.750 re f 360.669 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 360.798 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 391.983 372.468 57.366 0.750 re f 391.983 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 360.798 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 448.598 372.468 38.912 0.750 re f 448.598 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 360.798 Td /F1 9.8 Tf [(0.8)] TJ ET 0.267 0.267 0.267 rg 486.760 372.468 55.953 0.750 re f 486.760 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 360.798 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 541.963 372.468 38.912 0.750 re f 541.963 350.490 0.750 22.728 re f 580.125 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 360.798 Td /F1 9.8 Tf [(0.8)] TJ ET 0.267 0.267 0.267 rg 26.625 350.490 81.984 0.750 re f 26.625 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 338.820 Td /F1 9.8 Tf [(Walker et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 326.440 Td /F4 8.7 Tf [(36)] TJ ET 0.271 0.267 0.267 rg BT 43.939 325.858 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 350.490 70.818 0.750 re f 107.859 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 338.820 Td /F1 9.8 Tf [(1981)] TJ ET 0.267 0.267 0.267 rg 177.927 350.490 80.585 0.750 re f 177.927 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 338.820 Td /F1 9.8 Tf [(South)] TJ ET BT 183.177 328.920 Td /F1 9.8 Tf [(Wales)] TJ ET 0.267 0.267 0.267 rg 257.761 350.490 47.042 0.750 re f 257.761 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 338.820 Td /F1 9.8 Tf [(333)] TJ ET 0.267 0.267 0.267 rg 304.053 350.490 57.366 0.750 re f 304.053 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 338.820 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 360.669 350.490 32.064 0.750 re f 360.669 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 338.820 Td /F1 9.8 Tf [(0.9)] TJ ET 0.267 0.267 0.267 rg 391.983 350.490 57.366 0.750 re f 391.983 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 338.820 Td /F1 9.8 Tf [(11)] TJ ET 0.267 0.267 0.267 rg 448.598 350.490 38.912 0.750 re f 448.598 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 338.820 Td /F1 9.8 Tf [(3.3)] TJ ET 0.267 0.267 0.267 rg 486.760 350.490 55.953 0.750 re f 486.760 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 338.820 Td /F1 9.8 Tf [(14)] TJ ET 0.267 0.267 0.267 rg 541.963 350.490 38.912 0.750 re f 541.963 318.612 0.750 32.628 re f 580.125 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 338.820 Td /F1 9.8 Tf [(4.2)] TJ ET 0.267 0.267 0.267 rg 26.625 318.612 81.984 0.750 re f 26.625 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 306.942 Td /F1 9.8 Tf [(*Hayden et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 294.562 Td /F4 8.7 Tf [(28)] TJ ET 0.271 0.267 0.267 rg BT 43.939 293.980 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 318.612 70.818 0.750 re f 107.859 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 306.942 Td /F1 9.8 Tf [(1982)] TJ ET 0.267 0.267 0.267 rg 177.927 318.612 80.585 0.750 re f 177.927 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 306.942 Td /F1 9.8 Tf [(S Africa )] TJ ET BT 183.177 297.042 Td /F1 9.8 Tf [(Total)] TJ ET 0.267 0.267 0.267 rg 257.761 318.612 47.042 0.750 re f 257.761 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 306.942 Td /F1 9.8 Tf [(219)] TJ ET 0.267 0.267 0.267 rg 304.053 318.612 57.366 0.750 re f 304.053 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 306.942 Td /F1 9.8 Tf [(6)] TJ ET 0.267 0.267 0.267 rg 360.669 318.612 32.064 0.750 re f 360.669 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 306.942 Td /F1 9.8 Tf [(2.7)] TJ ET 0.267 0.267 0.267 rg 391.983 318.612 57.366 0.750 re f 391.983 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 306.942 Td /F1 9.8 Tf [(11)] TJ ET 0.267 0.267 0.267 rg 448.598 318.612 38.912 0.750 re f 448.598 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 306.942 Td /F1 9.8 Tf [(5)] TJ ET 0.267 0.267 0.267 rg 486.760 318.612 55.953 0.750 re f 486.760 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 306.942 Td /F1 9.8 Tf [(17)] TJ ET 0.267 0.267 0.267 rg 541.963 318.612 38.912 0.750 re f 541.963 286.734 0.750 32.628 re f 580.125 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 306.942 Td /F1 9.8 Tf [(7.7)] TJ ET 0.267 0.267 0.267 rg 26.625 286.734 81.984 0.750 re f 26.625 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 31.875 275.064 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 286.734 70.818 0.750 re f 107.859 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 113.109 275.064 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 177.927 286.734 80.585 0.750 re f 177.927 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 183.177 275.064 Td /F1 9.8 Tf [(S Africa)] TJ ET BT 183.177 265.164 Td /F1 9.8 Tf [(Whites)] TJ ET 0.267 0.267 0.267 rg 257.761 286.734 47.042 0.750 re f 257.761 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 263.011 275.064 Td /F1 9.8 Tf [(147)] TJ ET 0.267 0.267 0.267 rg 304.053 286.734 57.366 0.750 re f 304.053 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 309.303 275.064 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 360.669 286.734 32.064 0.750 re f 360.669 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 365.919 275.064 Td /F1 9.8 Tf [(2.0)] TJ ET 0.267 0.267 0.267 rg 391.983 286.734 57.366 0.750 re f 391.983 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 397.233 275.064 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 448.598 286.734 38.912 0.750 re f 448.598 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 453.848 275.064 Td /F1 9.8 Tf [(2.0)] TJ ET 0.267 0.267 0.267 rg 486.760 286.734 55.953 0.750 re f 486.760 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 492.010 275.064 Td /F1 9.8 Tf [(6)] TJ ET 0.267 0.267 0.267 rg 541.963 286.734 38.912 0.750 re f 541.963 258.684 0.750 28.800 re f 580.125 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 547.213 275.064 Td /F1 9.8 Tf [(4.1)] TJ ET 0.267 0.267 0.267 rg 26.625 258.684 81.984 0.750 re f 26.625 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 31.875 247.014 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 258.684 70.818 0.750 re f 107.859 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 113.109 247.014 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 177.927 258.684 80.585 0.750 re f 177.927 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 183.177 247.014 Td /F1 9.8 Tf [(S Africa )] TJ ET BT 183.177 237.114 Td /F1 9.8 Tf [(Mixed)] TJ ET 0.267 0.267 0.267 rg 257.761 258.684 47.042 0.750 re f 257.761 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 263.011 247.014 Td /F1 9.8 Tf [(72)] TJ ET 0.267 0.267 0.267 rg 304.053 258.684 57.366 0.750 re f 304.053 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 309.303 247.014 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 360.669 258.684 32.064 0.750 re f 360.669 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 365.919 247.014 Td /F1 9.8 Tf [(4.2)] TJ ET 0.267 0.267 0.267 rg 391.983 258.684 57.366 0.750 re f 391.983 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 397.233 247.014 Td /F1 9.8 Tf [(8)] TJ ET 0.267 0.267 0.267 rg 448.598 258.684 38.912 0.750 re f 448.598 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 453.848 247.014 Td /F1 9.8 Tf [(11.1)] TJ ET 0.267 0.267 0.267 rg 486.760 258.684 55.953 0.750 re f 486.760 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 492.010 247.014 Td /F1 9.8 Tf [(11)] TJ ET 0.267 0.267 0.267 rg 541.963 258.684 38.912 0.750 re f 541.963 230.634 0.750 28.800 re f 580.125 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 547.213 247.014 Td /F1 9.8 Tf [(15.3)] TJ ET 0.267 0.267 0.267 rg 26.625 230.634 81.984 0.750 re f 26.625 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 31.875 218.964 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 230.634 70.818 0.750 re f 107.859 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 113.109 218.964 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 177.927 230.634 80.585 0.750 re f 177.927 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 183.177 218.964 Td /F1 9.8 Tf [(S Africa)] TJ ET BT 183.177 209.064 Td /F1 9.8 Tf [(Blacks)] TJ ET 0.267 0.267 0.267 rg 257.761 230.634 47.042 0.750 re f 257.761 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 263.011 218.964 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 304.053 230.634 57.366 0.750 re f 304.053 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 309.303 218.964 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 360.669 230.634 32.064 0.750 re f 360.669 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 365.919 218.964 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 391.983 230.634 57.366 0.750 re f 391.983 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 397.233 218.964 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 448.598 230.634 38.912 0.750 re f 448.598 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 453.848 218.964 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 486.760 230.634 55.953 0.750 re f 486.760 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 492.010 218.964 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 541.963 230.634 38.912 0.750 re f 541.963 202.584 0.750 28.800 re f 580.125 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 547.213 218.964 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 26.625 202.584 81.984 0.750 re f 26.625 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 187.852 Td /F1 9.8 Tf [(Myers et al)] TJ ET 0.267 0.267 0.267 rg BT 88.952 188.434 Td /F4 8.7 Tf [(37)] TJ ET 0.271 0.267 0.267 rg BT 31.875 177.186 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 202.584 70.818 0.750 re f 107.859 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 190.914 Td /F1 9.8 Tf [(1982)] TJ ET 0.267 0.267 0.267 rg 177.927 202.584 80.585 0.750 re f 177.927 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 190.914 Td /F1 9.8 Tf [(USA)] TJ ET 0.267 0.267 0.267 rg 257.761 202.584 47.042 0.750 re f 257.761 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 190.914 Td /F1 9.8 Tf [(83)] TJ ET 0.267 0.267 0.267 rg 304.053 202.584 57.366 0.750 re f 304.053 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 190.914 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 360.669 202.584 32.064 0.750 re f 360.669 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 190.914 Td /F1 9.8 Tf [(2.4)] TJ ET 0.267 0.267 0.267 rg 391.983 202.584 57.366 0.750 re f 391.983 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 190.914 Td /F1 9.8 Tf [(7)] TJ ET 0.267 0.267 0.267 rg 448.598 202.584 38.912 0.750 re f 448.598 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 190.914 Td /F1 9.8 Tf [(8.4)] TJ ET 0.267 0.267 0.267 rg 486.760 202.584 55.953 0.750 re f 486.760 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 190.914 Td /F1 9.8 Tf [(9)] TJ ET 0.267 0.267 0.267 rg 541.963 202.584 38.912 0.750 re f 541.963 170.706 0.750 32.628 re f 580.125 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 190.914 Td /F1 9.8 Tf [(10.8)] TJ ET 0.267 0.267 0.267 rg 26.625 170.706 81.984 0.750 re f 26.625 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 155.974 Td /F1 9.8 Tf [(Went et al)] TJ ET 0.267 0.267 0.267 rg BT 85.325 156.556 Td /F4 8.7 Tf [(38)] TJ ET 0.271 0.267 0.267 rg BT 97.389 155.974 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 170.706 70.818 0.750 re f 107.859 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 159.036 Td /F1 9.8 Tf [(1983)] TJ ET 0.267 0.267 0.267 rg 177.927 170.706 80.585 0.750 re f 177.927 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 159.036 Td /F1 9.8 Tf [(Netherlands)] TJ ET 0.267 0.267 0.267 rg 257.761 170.706 47.042 0.750 re f 257.761 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 159.036 Td /F1 9.8 Tf [(276)] TJ ET 0.267 0.267 0.267 rg 304.053 170.706 57.366 0.750 re f 304.053 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 159.036 Td /F1 9.8 Tf [(5)] TJ ET 0.267 0.267 0.267 rg 360.669 170.706 32.064 0.750 re f 360.669 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 159.036 Td /F1 9.8 Tf [(81.)] TJ ET 0.267 0.267 0.267 rg 391.983 170.706 57.366 0.750 re f 391.983 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 159.036 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 448.598 170.706 38.912 0.750 re f 448.598 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 159.036 Td /F1 9.8 Tf [(1.1)] TJ ET 0.267 0.267 0.267 rg 486.760 170.706 55.953 0.750 re f 486.760 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 159.036 Td /F1 9.8 Tf [(8)] TJ ET 0.267 0.267 0.267 rg 541.963 170.706 38.912 0.750 re f 541.963 148.728 0.750 22.728 re f 580.125 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 159.036 Td /F1 9.8 Tf [(2.9)] TJ ET 0.267 0.267 0.267 rg 26.625 148.728 81.984 0.750 re f 26.625 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 137.058 Td /F1 9.8 Tf [(Di Maio et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 124.678 Td /F4 8.7 Tf [(39)] TJ ET 0.271 0.267 0.267 rg BT 43.939 124.096 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 148.728 70.818 0.750 re f 107.859 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 137.058 Td /F1 9.8 Tf [(1984)] TJ ET 0.267 0.267 0.267 rg 177.927 148.728 80.585 0.750 re f 177.927 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 137.058 Td /F1 9.8 Tf [(Italy)] TJ ET 0.267 0.267 0.267 rg 257.761 148.728 47.042 0.750 re f 257.761 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 137.058 Td /F1 9.8 Tf [(95)] TJ ET 0.267 0.267 0.267 rg 304.053 148.728 57.366 0.750 re f 304.053 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 137.058 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 148.728 32.064 0.750 re f 360.669 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 137.058 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 148.728 57.366 0.750 re f 391.983 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 137.058 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 148.728 38.912 0.750 re f 448.598 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 137.058 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 148.728 55.953 0.750 re f 486.760 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 137.058 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 541.963 148.728 38.912 0.750 re f 541.963 116.850 0.750 32.628 re f 580.125 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 137.058 Td /F1 9.8 Tf [(4.2)] TJ ET 0.267 0.267 0.267 rg 26.625 116.850 81.984 0.750 re f 26.625 94.872 81.984 0.750 re f 26.625 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 102.118 Td /F1 9.8 Tf [(Went et al)] TJ ET 0.267 0.267 0.267 rg BT 85.325 102.700 Td /F4 8.7 Tf [(40)] TJ ET 0.271 0.267 0.267 rg BT 97.389 102.118 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 116.850 70.818 0.750 re f 107.859 94.872 70.818 0.750 re f 107.859 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 105.180 Td /F1 9.8 Tf [(1984)] TJ ET 0.267 0.267 0.267 rg 177.927 116.850 80.585 0.750 re f 177.927 94.872 80.585 0.750 re f 177.927 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 105.180 Td /F1 9.8 Tf [(Netherlands)] TJ ET 0.267 0.267 0.267 rg 257.761 116.850 47.042 0.750 re f 257.761 94.872 47.042 0.750 re f 257.761 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 105.180 Td /F1 9.8 Tf [(1246)] TJ ET 0.267 0.267 0.267 rg 304.053 116.850 57.366 0.750 re f 304.053 94.872 57.366 0.750 re f 304.053 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 105.180 Td /F1 9.8 Tf [(13)] TJ ET 0.267 0.267 0.267 rg 360.669 116.850 32.064 0.750 re f 360.669 94.872 32.064 0.750 re f 360.669 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 105.180 Td /F1 9.8 Tf [(1.0)] TJ ET 0.267 0.267 0.267 rg 391.983 116.850 57.366 0.750 re f 391.983 94.872 57.366 0.750 re f 391.983 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 105.180 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 448.598 116.850 38.912 0.750 re f 448.598 94.872 38.912 0.750 re f 448.598 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 105.180 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 486.760 116.850 55.953 0.750 re f 486.760 94.872 55.953 0.750 re f 486.760 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 105.180 Td /F1 9.8 Tf [(13)] TJ ET 0.267 0.267 0.267 rg 541.963 116.850 38.912 0.750 re f 541.963 94.872 38.912 0.750 re f 541.963 94.872 0.750 22.728 re f 580.125 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 105.180 Td /F1 9.8 Tf [(1.0)] TJ ET Q q 15.000 95.247 577.500 681.753 re W n q 26.250 759.180 555.000 17.820 re W n 0.271 0.267 0.267 rg BT 26.250 762.744 Td /F1 9.8 Tf [(Summary of all studies used in this analysis)] TJ ET Q 0.965 0.965 0.965 rg 26.250 712.086 555.000 39.594 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 751.680 m 581.250 751.680 l 580.500 750.930 l 27.000 750.930 l f 581.250 751.680 m 581.250 712.086 l 580.500 712.086 l 580.500 750.930 l f 26.250 751.680 m 26.250 712.086 l 27.000 712.086 l 27.000 750.930 l f 0.271 0.267 0.267 rg BT 33.000 734.792 Td /F1 9.0 Tf [(* refers to studies included in the original Hayden study)] TJ ET 0.267 0.267 0.267 rg BT 285.477 735.330 Td /F4 8.0 Tf [(11)] TJ ET 0.271 0.267 0.267 rg BT 296.613 734.792 Td /F1 9.0 Tf [( The paper from Pleydell 1954)] TJ ET 0.267 0.267 0.267 rg BT 435.789 735.330 Td /F4 8.0 Tf [(26)] TJ ET 0.271 0.267 0.267 rg BT 446.925 734.792 Td /F1 9.0 Tf [(was included with )] TJ ET BT 33.000 722.120 Td /F1 9.0 Tf [(additional data from Pleydell 1955)] TJ ET 0.267 0.267 0.267 rg BT 188.520 722.658 Td /F4 8.0 Tf [(27)] TJ ET 0.271 0.267 0.267 rg BT 199.656 722.120 Td /F1 9.0 Tf [( - means there was no furher specification of age)] TJ ET 1.000 1.000 1.000 rg 26.250 95.247 555.000 616.839 re f 0.965 0.965 0.965 rg 27.000 680.073 81.234 31.263 re f 0.267 0.267 0.267 rg 26.625 710.961 81.609 0.750 re f 26.625 679.698 0.750 32.013 re f 0.271 0.267 0.267 rg BT 31.500 698.981 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 108.234 680.073 70.068 31.263 re f 0.267 0.267 0.267 rg 108.234 710.961 70.068 0.750 re f 0.271 0.267 0.267 rg BT 112.734 698.981 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 178.302 680.073 79.835 31.263 re f 0.267 0.267 0.267 rg 178.302 710.961 79.835 0.750 re f 0.271 0.267 0.267 rg BT 182.802 698.981 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 258.136 680.073 46.292 31.263 re f 0.267 0.267 0.267 rg 258.136 710.961 46.292 0.750 re f 0.271 0.267 0.267 rg BT 262.636 698.981 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 304.428 680.073 56.616 31.263 re f 0.267 0.267 0.267 rg 304.428 710.961 56.616 0.750 re f 0.271 0.267 0.267 rg BT 308.928 698.981 Td /F4 9.8 Tf [(0 -10 )] TJ ET BT 308.928 683.537 Td /F4 9.8 Tf [(years)] TJ ET 0.965 0.965 0.965 rg 361.044 680.073 31.314 31.263 re f 0.267 0.267 0.267 rg 361.044 710.961 31.314 0.750 re f 0.271 0.267 0.267 rg BT 365.544 698.981 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 392.358 680.073 56.616 31.263 re f 0.267 0.267 0.267 rg 392.358 710.961 56.616 0.750 re f 0.271 0.267 0.267 rg BT 396.858 698.981 Td /F4 9.8 Tf [(11-20 )] TJ ET BT 396.858 683.537 Td /F4 9.8 Tf [(years)] TJ ET 0.965 0.965 0.965 rg 448.973 680.073 38.162 31.263 re f 0.267 0.267 0.267 rg 448.973 710.961 38.162 0.750 re f 0.271 0.267 0.267 rg BT 453.473 698.981 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 487.135 680.073 55.203 31.263 re f 0.267 0.267 0.267 rg 487.135 710.961 55.203 0.750 re f 0.271 0.267 0.267 rg BT 491.635 698.981 Td /F4 9.8 Tf [(Total )] TJ ET BT 491.635 683.537 Td /F4 9.8 Tf [(JHD)] TJ ET 0.965 0.965 0.965 rg 542.338 680.073 38.162 31.263 re f 0.267 0.267 0.267 rg 542.338 710.961 38.537 0.750 re f 580.125 679.698 0.750 32.013 re f 0.271 0.267 0.267 rg BT 546.838 698.981 Td /F4 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 26.625 679.698 81.984 0.750 re f 26.625 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 31.875 668.028 Td /F1 9.8 Tf [(Authors)] TJ ET 0.267 0.267 0.267 rg 107.859 679.698 70.818 0.750 re f 107.859 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 113.109 668.028 Td /F1 9.8 Tf [(Publication)] TJ ET BT 113.109 658.128 Td /F1 9.8 Tf [(year)] TJ ET 0.267 0.267 0.267 rg 177.927 679.698 80.585 0.750 re f 177.927 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 183.177 668.028 Td /F1 9.8 Tf [(Location)] TJ ET 0.267 0.267 0.267 rg 257.761 679.698 47.042 0.750 re f 257.761 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 263.011 668.028 Td /F1 9.8 Tf [(Total )] TJ ET BT 263.011 658.128 Td /F1 9.8 Tf [(HD )] TJ ET BT 263.011 648.228 Td /F1 9.8 Tf [(cases)] TJ ET 0.267 0.267 0.267 rg 304.053 679.698 57.366 0.750 re f 304.053 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 309.303 668.028 Td /F1 9.8 Tf [(Number)] TJ ET 0.267 0.267 0.267 rg 360.669 679.698 32.064 0.750 re f 360.669 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 365.919 668.028 Td /F1 9.8 Tf [(%)] TJ ET 0.267 0.267 0.267 rg 391.983 679.698 57.366 0.750 re f 391.983 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 397.233 668.028 Td /F1 9.8 Tf [(Number)] TJ ET 0.267 0.267 0.267 rg 448.598 679.698 38.912 0.750 re f 448.598 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 453.848 668.028 Td /F1 9.8 Tf [(%)] TJ ET 0.267 0.267 0.267 rg 486.760 679.698 55.953 0.750 re f 486.760 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 492.010 668.028 Td /F1 9.8 Tf [(Number)] TJ ET 0.267 0.267 0.267 rg 541.963 679.698 38.912 0.750 re f 541.963 641.748 0.750 38.700 re f 580.125 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 547.213 668.028 Td /F1 9.8 Tf [(%)] TJ ET 0.267 0.267 0.267 rg 26.625 641.748 81.984 0.750 re f 26.625 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 630.078 Td /F1 9.8 Tf [(*Davenport )] TJ ET BT 31.875 617.116 Td /F1 9.8 Tf [(& Muncey)] TJ ET 0.267 0.267 0.267 rg BT 80.489 617.698 Td /F4 8.7 Tf [(29)] TJ ET 0.271 0.267 0.267 rg BT 92.553 617.116 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 641.748 70.818 0.750 re f 107.859 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 630.078 Td /F1 9.8 Tf [(1916)] TJ ET 0.267 0.267 0.267 rg 177.927 641.748 80.585 0.750 re f 177.927 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 630.078 Td /F1 9.8 Tf [(USA)] TJ ET 0.267 0.267 0.267 rg 257.761 641.748 47.042 0.750 re f 257.761 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 630.078 Td /F1 9.8 Tf [(138)] TJ ET 0.267 0.267 0.267 rg 304.053 641.748 57.366 0.750 re f 304.053 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 630.078 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 360.669 641.748 32.064 0.750 re f 360.669 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 630.078 Td /F1 9.8 Tf [(2.2)] TJ ET 0.267 0.267 0.267 rg 391.983 641.748 57.366 0.750 re f 391.983 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 630.078 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 448.598 641.748 38.912 0.750 re f 448.598 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 630.078 Td /F1 9.8 Tf [(1.4)] TJ ET 0.267 0.267 0.267 rg 486.760 641.748 55.953 0.750 re f 486.760 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 630.078 Td /F1 9.8 Tf [(5)] TJ ET 0.267 0.267 0.267 rg 541.963 641.748 38.912 0.750 re f 541.963 609.870 0.750 32.628 re f 580.125 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 630.078 Td /F1 9.8 Tf [(3.6)] TJ ET 0.267 0.267 0.267 rg 26.625 609.870 81.984 0.750 re f 26.625 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 598.200 Td /F1 9.8 Tf [(*Spillane &)] TJ ET BT 31.875 585.238 Td /F1 9.8 Tf [(Phillips)] TJ ET 0.267 0.267 0.267 rg BT 66.049 585.820 Td /F4 8.7 Tf [(30)] TJ ET 0.271 0.267 0.267 rg BT 78.113 585.238 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 609.870 70.818 0.750 re f 107.859 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 598.200 Td /F1 9.8 Tf [(1937)] TJ ET 0.267 0.267 0.267 rg 177.927 609.870 80.585 0.750 re f 177.927 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 598.200 Td /F1 9.8 Tf [(South )] TJ ET BT 183.177 588.300 Td /F1 9.8 Tf [(Wales)] TJ ET 0.267 0.267 0.267 rg 257.761 609.870 47.042 0.750 re f 257.761 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 598.200 Td /F1 9.8 Tf [(21)] TJ ET 0.267 0.267 0.267 rg 304.053 609.870 57.366 0.750 re f 304.053 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 598.200 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 609.870 32.064 0.750 re f 360.669 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 598.200 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 609.870 57.366 0.750 re f 391.983 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 598.200 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 448.598 609.870 38.912 0.750 re f 448.598 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 598.200 Td /F1 9.8 Tf [(9.5)] TJ ET 0.267 0.267 0.267 rg 486.760 609.870 55.953 0.750 re f 486.760 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 598.200 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 541.963 609.870 38.912 0.750 re f 541.963 577.992 0.750 32.628 re f 580.125 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 598.200 Td /F1 9.8 Tf [(9.5)] TJ ET 0.267 0.267 0.267 rg 26.625 577.992 81.984 0.750 re f 26.625 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 563.260 Td /F1 9.8 Tf [(*Panse)] TJ ET 0.267 0.267 0.267 rg BT 68.964 563.842 Td /F4 8.7 Tf [(20)] TJ ET 0.271 0.267 0.267 rg BT 81.028 563.260 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 577.992 70.818 0.750 re f 107.859 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 566.322 Td /F1 9.8 Tf [(1942)] TJ ET 0.267 0.267 0.267 rg 177.927 577.992 80.585 0.750 re f 177.927 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 566.322 Td /F1 9.8 Tf [(Germany)] TJ ET 0.267 0.267 0.267 rg 257.761 577.992 47.042 0.750 re f 257.761 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 566.322 Td /F1 9.8 Tf [(446)] TJ ET 0.267 0.267 0.267 rg 304.053 577.992 57.366 0.750 re f 304.053 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 566.322 Td /F1 9.8 Tf [(7)] TJ ET 0.267 0.267 0.267 rg 360.669 577.992 32.064 0.750 re f 360.669 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 566.322 Td /F1 9.8 Tf [(1.6)] TJ ET 0.267 0.267 0.267 rg 391.983 577.992 57.366 0.750 re f 391.983 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 566.322 Td /F1 9.8 Tf [(17)] TJ ET 0.267 0.267 0.267 rg 448.598 577.992 38.912 0.750 re f 448.598 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 566.322 Td /F1 9.8 Tf [(3.8)] TJ ET 0.267 0.267 0.267 rg 486.760 577.992 55.953 0.750 re f 486.760 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 566.322 Td /F1 9.8 Tf [(24)] TJ ET 0.267 0.267 0.267 rg 541.963 577.992 38.912 0.750 re f 541.963 556.014 0.750 22.728 re f 580.125 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 566.322 Td /F1 9.8 Tf [(5.4)] TJ ET 0.267 0.267 0.267 rg 26.625 556.014 81.984 0.750 re f 26.625 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 541.282 Td /F1 9.8 Tf [(Pleydell)] TJ ET 0.267 0.267 0.267 rg BT 72.942 541.864 Td /F4 8.7 Tf [(26)] TJ ET 0.271 0.267 0.267 rg BT 85.006 541.282 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 556.014 70.818 0.750 re f 107.859 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 544.344 Td /F1 9.8 Tf [(1954)] TJ ET 0.267 0.267 0.267 rg 177.927 556.014 80.585 0.750 re f 177.927 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 544.344 Td /F1 9.8 Tf [(England)] TJ ET 0.267 0.267 0.267 rg 257.761 556.014 47.042 0.750 re f 257.761 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 544.344 Td /F1 9.8 Tf [(17)] TJ ET 0.267 0.267 0.267 rg 304.053 556.014 57.366 0.750 re f 304.053 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 544.344 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 556.014 32.064 0.750 re f 360.669 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 544.344 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 556.014 57.366 0.750 re f 391.983 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 544.344 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 448.598 556.014 38.912 0.750 re f 448.598 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 544.344 Td /F1 9.8 Tf [(11.8)] TJ ET 0.267 0.267 0.267 rg 486.760 556.014 55.953 0.750 re f 486.760 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 544.344 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 541.963 556.014 38.912 0.750 re f 541.963 534.036 0.750 22.728 re f 580.125 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 544.344 Td /F1 9.8 Tf [(11.8)] TJ ET 0.267 0.267 0.267 rg 26.625 534.036 81.984 0.750 re f 26.625 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 522.366 Td /F1 9.8 Tf [(*Reed )] TJ ET BT 31.875 509.404 Td /F1 9.8 Tf [(et al)] TJ ET 0.267 0.267 0.267 rg BT 53.481 509.986 Td /F4 8.7 Tf [(18)] TJ ET 0.271 0.267 0.267 rg BT 65.545 509.404 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 534.036 70.818 0.750 re f 107.859 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 522.366 Td /F1 9.8 Tf [(1958)] TJ ET 0.267 0.267 0.267 rg 177.927 534.036 80.585 0.750 re f 177.927 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 522.366 Td /F1 9.8 Tf [(USA)] TJ ET 0.267 0.267 0.267 rg 257.761 534.036 47.042 0.750 re f 257.761 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 522.366 Td /F1 9.8 Tf [(203)] TJ ET 0.267 0.267 0.267 rg 304.053 534.036 57.366 0.750 re f 304.053 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 522.366 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 534.036 32.064 0.750 re f 360.669 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 522.366 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 534.036 57.366 0.750 re f 391.983 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 522.366 Td /F1 9.8 Tf [(12)] TJ ET 0.267 0.267 0.267 rg 448.598 534.036 38.912 0.750 re f 448.598 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 522.366 Td /F1 9.8 Tf [(5.9)] TJ ET 0.267 0.267 0.267 rg 486.760 534.036 55.953 0.750 re f 486.760 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 522.366 Td /F1 9.8 Tf [(12)] TJ ET 0.267 0.267 0.267 rg 541.963 534.036 38.912 0.750 re f 541.963 502.158 0.750 32.628 re f 580.125 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 522.366 Td /F1 9.8 Tf [(5.9)] TJ ET 0.267 0.267 0.267 rg 26.625 502.158 81.984 0.750 re f 26.625 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 487.426 Td /F1 9.8 Tf [(*Brothers)] TJ ET 0.267 0.267 0.267 rg BT 78.499 488.008 Td /F4 8.7 Tf [(31)] TJ ET 0.271 0.267 0.267 rg BT 90.564 487.426 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 502.158 70.818 0.750 re f 107.859 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 490.488 Td /F1 9.8 Tf [(1964)] TJ ET 0.267 0.267 0.267 rg 177.927 502.158 80.585 0.750 re f 177.927 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 490.488 Td /F1 9.8 Tf [(Australia)] TJ ET 0.267 0.267 0.267 rg 257.761 502.158 47.042 0.750 re f 257.761 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 490.488 Td /F1 9.8 Tf [(206)] TJ ET 0.267 0.267 0.267 rg 304.053 502.158 57.366 0.750 re f 304.053 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 490.488 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 360.669 502.158 32.064 0.750 re f 360.669 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 490.488 Td /F1 9.8 Tf [(1.9)] TJ ET 0.267 0.267 0.267 rg 391.983 502.158 57.366 0.750 re f 391.983 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 490.488 Td /F1 9.8 Tf [(11)] TJ ET 0.267 0.267 0.267 rg 448.598 502.158 38.912 0.750 re f 448.598 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 490.488 Td /F1 9.8 Tf [(5.3)] TJ ET 0.267 0.267 0.267 rg 486.760 502.158 55.953 0.750 re f 486.760 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 490.488 Td /F1 9.8 Tf [(15)] TJ ET 0.267 0.267 0.267 rg 541.963 502.158 38.912 0.750 re f 541.963 480.180 0.750 22.728 re f 580.125 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 490.488 Td /F1 9.8 Tf [(7.3)] TJ ET 0.267 0.267 0.267 rg 26.625 480.180 81.984 0.750 re f 26.625 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 468.510 Td /F1 9.8 Tf [(*Cameron )] TJ ET BT 31.875 455.548 Td /F1 9.8 Tf [(& Venters)] TJ ET 0.267 0.267 0.267 rg BT 80.333 456.130 Td /F4 8.7 Tf [(24)] TJ ET 0.271 0.267 0.267 rg BT 92.397 455.548 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 480.180 70.818 0.750 re f 107.859 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 468.510 Td /F1 9.8 Tf [(1967)] TJ ET 0.267 0.267 0.267 rg 177.927 480.180 80.585 0.750 re f 177.927 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 468.510 Td /F1 9.8 Tf [(Scotland)] TJ ET 0.267 0.267 0.267 rg 257.761 480.180 47.042 0.750 re f 257.761 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 468.510 Td /F1 9.8 Tf [(143)] TJ ET 0.267 0.267 0.267 rg 304.053 480.180 57.366 0.750 re f 304.053 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 468.510 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 480.180 32.064 0.750 re f 360.669 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 468.510 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 480.180 57.366 0.750 re f 391.983 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 468.510 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 480.180 38.912 0.750 re f 448.598 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 468.510 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 480.180 55.953 0.750 re f 486.760 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 468.510 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 541.963 480.180 38.912 0.750 re f 541.963 448.302 0.750 32.628 re f 580.125 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 468.510 Td /F1 9.8 Tf [(21)] TJ ET 0.267 0.267 0.267 rg 26.625 448.302 81.984 0.750 re f 26.625 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 433.570 Td /F1 9.8 Tf [(*Heathfield)] TJ ET 0.267 0.267 0.267 rg BT 90.200 434.152 Td /F4 8.7 Tf [(32)] TJ ET 0.271 0.267 0.267 rg BT 31.875 422.904 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 448.302 70.818 0.750 re f 107.859 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 436.632 Td /F1 9.8 Tf [(1967)] TJ ET 0.267 0.267 0.267 rg 177.927 448.302 80.585 0.750 re f 177.927 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 436.632 Td /F1 9.8 Tf [(England)] TJ ET 0.267 0.267 0.267 rg 257.761 448.302 47.042 0.750 re f 257.761 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 436.632 Td /F1 9.8 Tf [(81)] TJ ET 0.267 0.267 0.267 rg 304.053 448.302 57.366 0.750 re f 304.053 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 436.632 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 448.302 32.064 0.750 re f 360.669 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 436.632 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 448.302 57.366 0.750 re f 391.983 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 436.632 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 448.598 448.302 38.912 0.750 re f 448.598 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 436.632 Td /F1 9.8 Tf [(2.5)] TJ ET 0.267 0.267 0.267 rg 486.760 448.302 55.953 0.750 re f 486.760 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 436.632 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 541.963 448.302 38.912 0.750 re f 541.963 416.424 0.750 32.628 re f 580.125 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 436.632 Td /F1 9.8 Tf [(2.5)] TJ ET 0.267 0.267 0.267 rg 26.625 416.424 81.984 0.750 re f 26.625 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 401.692 Td /F1 9.8 Tf [(*Oliver)] TJ ET 0.267 0.267 0.267 rg BT 65.620 402.274 Td /F4 8.7 Tf [(33)] TJ ET 0.271 0.267 0.267 rg BT 77.684 401.692 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 416.424 70.818 0.750 re f 107.859 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 404.754 Td /F1 9.8 Tf [(1970)] TJ ET 0.267 0.267 0.267 rg 177.927 416.424 80.585 0.750 re f 177.927 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 404.754 Td /F1 9.8 Tf [(England)] TJ ET 0.267 0.267 0.267 rg 257.761 416.424 47.042 0.750 re f 257.761 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 404.754 Td /F1 9.8 Tf [(115)] TJ ET 0.267 0.267 0.267 rg 304.053 416.424 57.366 0.750 re f 304.053 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 404.754 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 360.669 416.424 32.064 0.750 re f 360.669 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 404.754 Td /F1 9.8 Tf [(3.5)] TJ ET 0.267 0.267 0.267 rg 391.983 416.424 57.366 0.750 re f 391.983 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 404.754 Td /F1 9.8 Tf [(7)] TJ ET 0.267 0.267 0.267 rg 448.598 416.424 38.912 0.750 re f 448.598 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 404.754 Td /F1 9.8 Tf [(6.1)] TJ ET 0.267 0.267 0.267 rg 486.760 416.424 55.953 0.750 re f 486.760 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 404.754 Td /F1 9.8 Tf [(11)] TJ ET 0.267 0.267 0.267 rg 541.963 416.424 38.912 0.750 re f 541.963 394.446 0.750 22.728 re f 580.125 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 404.754 Td /F1 9.8 Tf [(9.6)] TJ ET 0.267 0.267 0.267 rg 26.625 394.446 81.984 0.750 re f 26.625 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 379.714 Td /F1 9.8 Tf [(*Mattsson)] TJ ET 0.267 0.267 0.267 rg BT 84.194 380.296 Td /F4 8.7 Tf [(34)] TJ ET 0.271 0.267 0.267 rg BT 96.258 379.714 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 394.446 70.818 0.750 re f 107.859 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 382.776 Td /F1 9.8 Tf [(1974)] TJ ET 0.267 0.267 0.267 rg 177.927 394.446 80.585 0.750 re f 177.927 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 382.776 Td /F1 9.8 Tf [(Sweden)] TJ ET 0.267 0.267 0.267 rg 257.761 394.446 47.042 0.750 re f 257.761 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 382.776 Td /F1 9.8 Tf [(362)] TJ ET 0.267 0.267 0.267 rg 304.053 394.446 57.366 0.750 re f 304.053 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 382.776 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 394.446 32.064 0.750 re f 360.669 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 382.776 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 394.446 57.366 0.750 re f 391.983 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 382.776 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 394.446 38.912 0.750 re f 448.598 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 382.776 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 394.446 55.953 0.750 re f 486.760 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 382.776 Td /F1 9.8 Tf [(17)] TJ ET 0.267 0.267 0.267 rg 541.963 394.446 38.912 0.750 re f 541.963 372.468 0.750 22.728 re f 580.125 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 382.776 Td /F1 9.8 Tf [(4.7)] TJ ET 0.267 0.267 0.267 rg 26.625 372.468 81.984 0.750 re f 26.625 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 357.736 Td /F1 9.8 Tf [(*Stevens)] TJ ET 0.267 0.267 0.267 rg BT 78.889 358.318 Td /F4 8.7 Tf [(35)] TJ ET 0.271 0.267 0.267 rg BT 90.954 357.736 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 372.468 70.818 0.750 re f 107.859 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 360.798 Td /F1 9.8 Tf [(1976)] TJ ET 0.267 0.267 0.267 rg 177.927 372.468 80.585 0.750 re f 177.927 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 360.798 Td /F1 9.8 Tf [(England)] TJ ET 0.267 0.267 0.267 rg 257.761 372.468 47.042 0.750 re f 257.761 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 360.798 Td /F1 9.8 Tf [(133)] TJ ET 0.267 0.267 0.267 rg 304.053 372.468 57.366 0.750 re f 304.053 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 360.798 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 372.468 32.064 0.750 re f 360.669 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 360.798 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 391.983 372.468 57.366 0.750 re f 391.983 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 360.798 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 448.598 372.468 38.912 0.750 re f 448.598 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 360.798 Td /F1 9.8 Tf [(0.8)] TJ ET 0.267 0.267 0.267 rg 486.760 372.468 55.953 0.750 re f 486.760 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 360.798 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 541.963 372.468 38.912 0.750 re f 541.963 350.490 0.750 22.728 re f 580.125 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 360.798 Td /F1 9.8 Tf [(0.8)] TJ ET 0.267 0.267 0.267 rg 26.625 350.490 81.984 0.750 re f 26.625 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 338.820 Td /F1 9.8 Tf [(Walker et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 326.440 Td /F4 8.7 Tf [(36)] TJ ET 0.271 0.267 0.267 rg BT 43.939 325.858 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 350.490 70.818 0.750 re f 107.859 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 338.820 Td /F1 9.8 Tf [(1981)] TJ ET 0.267 0.267 0.267 rg 177.927 350.490 80.585 0.750 re f 177.927 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 338.820 Td /F1 9.8 Tf [(South)] TJ ET BT 183.177 328.920 Td /F1 9.8 Tf [(Wales)] TJ ET 0.267 0.267 0.267 rg 257.761 350.490 47.042 0.750 re f 257.761 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 338.820 Td /F1 9.8 Tf [(333)] TJ ET 0.267 0.267 0.267 rg 304.053 350.490 57.366 0.750 re f 304.053 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 338.820 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 360.669 350.490 32.064 0.750 re f 360.669 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 338.820 Td /F1 9.8 Tf [(0.9)] TJ ET 0.267 0.267 0.267 rg 391.983 350.490 57.366 0.750 re f 391.983 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 338.820 Td /F1 9.8 Tf [(11)] TJ ET 0.267 0.267 0.267 rg 448.598 350.490 38.912 0.750 re f 448.598 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 338.820 Td /F1 9.8 Tf [(3.3)] TJ ET 0.267 0.267 0.267 rg 486.760 350.490 55.953 0.750 re f 486.760 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 338.820 Td /F1 9.8 Tf [(14)] TJ ET 0.267 0.267 0.267 rg 541.963 350.490 38.912 0.750 re f 541.963 318.612 0.750 32.628 re f 580.125 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 338.820 Td /F1 9.8 Tf [(4.2)] TJ ET 0.267 0.267 0.267 rg 26.625 318.612 81.984 0.750 re f 26.625 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 306.942 Td /F1 9.8 Tf [(*Hayden et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 294.562 Td /F4 8.7 Tf [(28)] TJ ET 0.271 0.267 0.267 rg BT 43.939 293.980 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 318.612 70.818 0.750 re f 107.859 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 306.942 Td /F1 9.8 Tf [(1982)] TJ ET 0.267 0.267 0.267 rg 177.927 318.612 80.585 0.750 re f 177.927 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 306.942 Td /F1 9.8 Tf [(S Africa )] TJ ET BT 183.177 297.042 Td /F1 9.8 Tf [(Total)] TJ ET 0.267 0.267 0.267 rg 257.761 318.612 47.042 0.750 re f 257.761 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 306.942 Td /F1 9.8 Tf [(219)] TJ ET 0.267 0.267 0.267 rg 304.053 318.612 57.366 0.750 re f 304.053 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 306.942 Td /F1 9.8 Tf [(6)] TJ ET 0.267 0.267 0.267 rg 360.669 318.612 32.064 0.750 re f 360.669 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 306.942 Td /F1 9.8 Tf [(2.7)] TJ ET 0.267 0.267 0.267 rg 391.983 318.612 57.366 0.750 re f 391.983 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 306.942 Td /F1 9.8 Tf [(11)] TJ ET 0.267 0.267 0.267 rg 448.598 318.612 38.912 0.750 re f 448.598 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 306.942 Td /F1 9.8 Tf [(5)] TJ ET 0.267 0.267 0.267 rg 486.760 318.612 55.953 0.750 re f 486.760 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 306.942 Td /F1 9.8 Tf [(17)] TJ ET 0.267 0.267 0.267 rg 541.963 318.612 38.912 0.750 re f 541.963 286.734 0.750 32.628 re f 580.125 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 306.942 Td /F1 9.8 Tf [(7.7)] TJ ET 0.267 0.267 0.267 rg 26.625 286.734 81.984 0.750 re f 26.625 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 31.875 275.064 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 286.734 70.818 0.750 re f 107.859 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 113.109 275.064 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 177.927 286.734 80.585 0.750 re f 177.927 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 183.177 275.064 Td /F1 9.8 Tf [(S Africa)] TJ ET BT 183.177 265.164 Td /F1 9.8 Tf [(Whites)] TJ ET 0.267 0.267 0.267 rg 257.761 286.734 47.042 0.750 re f 257.761 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 263.011 275.064 Td /F1 9.8 Tf [(147)] TJ ET 0.267 0.267 0.267 rg 304.053 286.734 57.366 0.750 re f 304.053 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 309.303 275.064 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 360.669 286.734 32.064 0.750 re f 360.669 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 365.919 275.064 Td /F1 9.8 Tf [(2.0)] TJ ET 0.267 0.267 0.267 rg 391.983 286.734 57.366 0.750 re f 391.983 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 397.233 275.064 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 448.598 286.734 38.912 0.750 re f 448.598 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 453.848 275.064 Td /F1 9.8 Tf [(2.0)] TJ ET 0.267 0.267 0.267 rg 486.760 286.734 55.953 0.750 re f 486.760 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 492.010 275.064 Td /F1 9.8 Tf [(6)] TJ ET 0.267 0.267 0.267 rg 541.963 286.734 38.912 0.750 re f 541.963 258.684 0.750 28.800 re f 580.125 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 547.213 275.064 Td /F1 9.8 Tf [(4.1)] TJ ET 0.267 0.267 0.267 rg 26.625 258.684 81.984 0.750 re f 26.625 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 31.875 247.014 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 258.684 70.818 0.750 re f 107.859 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 113.109 247.014 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 177.927 258.684 80.585 0.750 re f 177.927 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 183.177 247.014 Td /F1 9.8 Tf [(S Africa )] TJ ET BT 183.177 237.114 Td /F1 9.8 Tf [(Mixed)] TJ ET 0.267 0.267 0.267 rg 257.761 258.684 47.042 0.750 re f 257.761 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 263.011 247.014 Td /F1 9.8 Tf [(72)] TJ ET 0.267 0.267 0.267 rg 304.053 258.684 57.366 0.750 re f 304.053 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 309.303 247.014 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 360.669 258.684 32.064 0.750 re f 360.669 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 365.919 247.014 Td /F1 9.8 Tf [(4.2)] TJ ET 0.267 0.267 0.267 rg 391.983 258.684 57.366 0.750 re f 391.983 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 397.233 247.014 Td /F1 9.8 Tf [(8)] TJ ET 0.267 0.267 0.267 rg 448.598 258.684 38.912 0.750 re f 448.598 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 453.848 247.014 Td /F1 9.8 Tf [(11.1)] TJ ET 0.267 0.267 0.267 rg 486.760 258.684 55.953 0.750 re f 486.760 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 492.010 247.014 Td /F1 9.8 Tf [(11)] TJ ET 0.267 0.267 0.267 rg 541.963 258.684 38.912 0.750 re f 541.963 230.634 0.750 28.800 re f 580.125 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 547.213 247.014 Td /F1 9.8 Tf [(15.3)] TJ ET 0.267 0.267 0.267 rg 26.625 230.634 81.984 0.750 re f 26.625 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 31.875 218.964 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 230.634 70.818 0.750 re f 107.859 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 113.109 218.964 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 177.927 230.634 80.585 0.750 re f 177.927 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 183.177 218.964 Td /F1 9.8 Tf [(S Africa)] TJ ET BT 183.177 209.064 Td /F1 9.8 Tf [(Blacks)] TJ ET 0.267 0.267 0.267 rg 257.761 230.634 47.042 0.750 re f 257.761 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 263.011 218.964 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 304.053 230.634 57.366 0.750 re f 304.053 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 309.303 218.964 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 360.669 230.634 32.064 0.750 re f 360.669 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 365.919 218.964 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 391.983 230.634 57.366 0.750 re f 391.983 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 397.233 218.964 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 448.598 230.634 38.912 0.750 re f 448.598 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 453.848 218.964 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 486.760 230.634 55.953 0.750 re f 486.760 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 492.010 218.964 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 541.963 230.634 38.912 0.750 re f 541.963 202.584 0.750 28.800 re f 580.125 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 547.213 218.964 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 26.625 202.584 81.984 0.750 re f 26.625 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 187.852 Td /F1 9.8 Tf [(Myers et al)] TJ ET 0.267 0.267 0.267 rg BT 88.952 188.434 Td /F4 8.7 Tf [(37)] TJ ET 0.271 0.267 0.267 rg BT 31.875 177.186 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 202.584 70.818 0.750 re f 107.859 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 190.914 Td /F1 9.8 Tf [(1982)] TJ ET 0.267 0.267 0.267 rg 177.927 202.584 80.585 0.750 re f 177.927 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 190.914 Td /F1 9.8 Tf [(USA)] TJ ET 0.267 0.267 0.267 rg 257.761 202.584 47.042 0.750 re f 257.761 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 190.914 Td /F1 9.8 Tf [(83)] TJ ET 0.267 0.267 0.267 rg 304.053 202.584 57.366 0.750 re f 304.053 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 190.914 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 360.669 202.584 32.064 0.750 re f 360.669 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 190.914 Td /F1 9.8 Tf [(2.4)] TJ ET 0.267 0.267 0.267 rg 391.983 202.584 57.366 0.750 re f 391.983 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 190.914 Td /F1 9.8 Tf [(7)] TJ ET 0.267 0.267 0.267 rg 448.598 202.584 38.912 0.750 re f 448.598 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 190.914 Td /F1 9.8 Tf [(8.4)] TJ ET 0.267 0.267 0.267 rg 486.760 202.584 55.953 0.750 re f 486.760 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 190.914 Td /F1 9.8 Tf [(9)] TJ ET 0.267 0.267 0.267 rg 541.963 202.584 38.912 0.750 re f 541.963 170.706 0.750 32.628 re f 580.125 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 190.914 Td /F1 9.8 Tf [(10.8)] TJ ET 0.267 0.267 0.267 rg 26.625 170.706 81.984 0.750 re f 26.625 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 155.974 Td /F1 9.8 Tf [(Went et al)] TJ ET 0.267 0.267 0.267 rg BT 85.325 156.556 Td /F4 8.7 Tf [(38)] TJ ET 0.271 0.267 0.267 rg BT 97.389 155.974 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 170.706 70.818 0.750 re f 107.859 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 159.036 Td /F1 9.8 Tf [(1983)] TJ ET 0.267 0.267 0.267 rg 177.927 170.706 80.585 0.750 re f 177.927 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 159.036 Td /F1 9.8 Tf [(Netherlands)] TJ ET 0.267 0.267 0.267 rg 257.761 170.706 47.042 0.750 re f 257.761 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 159.036 Td /F1 9.8 Tf [(276)] TJ ET 0.267 0.267 0.267 rg 304.053 170.706 57.366 0.750 re f 304.053 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 159.036 Td /F1 9.8 Tf [(5)] TJ ET 0.267 0.267 0.267 rg 360.669 170.706 32.064 0.750 re f 360.669 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 159.036 Td /F1 9.8 Tf [(81.)] TJ ET 0.267 0.267 0.267 rg 391.983 170.706 57.366 0.750 re f 391.983 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 159.036 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 448.598 170.706 38.912 0.750 re f 448.598 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 159.036 Td /F1 9.8 Tf [(1.1)] TJ ET 0.267 0.267 0.267 rg 486.760 170.706 55.953 0.750 re f 486.760 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 159.036 Td /F1 9.8 Tf [(8)] TJ ET 0.267 0.267 0.267 rg 541.963 170.706 38.912 0.750 re f 541.963 148.728 0.750 22.728 re f 580.125 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 159.036 Td /F1 9.8 Tf [(2.9)] TJ ET 0.267 0.267 0.267 rg 26.625 148.728 81.984 0.750 re f 26.625 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 137.058 Td /F1 9.8 Tf [(Di Maio et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 124.678 Td /F4 8.7 Tf [(39)] TJ ET 0.271 0.267 0.267 rg BT 43.939 124.096 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 148.728 70.818 0.750 re f 107.859 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 137.058 Td /F1 9.8 Tf [(1984)] TJ ET 0.267 0.267 0.267 rg 177.927 148.728 80.585 0.750 re f 177.927 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 137.058 Td /F1 9.8 Tf [(Italy)] TJ ET 0.267 0.267 0.267 rg 257.761 148.728 47.042 0.750 re f 257.761 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 137.058 Td /F1 9.8 Tf [(95)] TJ ET 0.267 0.267 0.267 rg 304.053 148.728 57.366 0.750 re f 304.053 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 137.058 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 148.728 32.064 0.750 re f 360.669 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 137.058 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 148.728 57.366 0.750 re f 391.983 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 137.058 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 148.728 38.912 0.750 re f 448.598 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 137.058 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 148.728 55.953 0.750 re f 486.760 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 137.058 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 541.963 148.728 38.912 0.750 re f 541.963 116.850 0.750 32.628 re f 580.125 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 137.058 Td /F1 9.8 Tf [(4.2)] TJ ET 0.267 0.267 0.267 rg 26.625 116.850 81.984 0.750 re f 26.625 94.872 81.984 0.750 re f 26.625 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 102.118 Td /F1 9.8 Tf [(Went et al)] TJ ET 0.267 0.267 0.267 rg BT 85.325 102.700 Td /F4 8.7 Tf [(40)] TJ ET 0.271 0.267 0.267 rg BT 97.389 102.118 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 116.850 70.818 0.750 re f 107.859 94.872 70.818 0.750 re f 107.859 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 105.180 Td /F1 9.8 Tf [(1984)] TJ ET 0.267 0.267 0.267 rg 177.927 116.850 80.585 0.750 re f 177.927 94.872 80.585 0.750 re f 177.927 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 105.180 Td /F1 9.8 Tf [(Netherlands)] TJ ET 0.267 0.267 0.267 rg 257.761 116.850 47.042 0.750 re f 257.761 94.872 47.042 0.750 re f 257.761 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 105.180 Td /F1 9.8 Tf [(1246)] TJ ET 0.267 0.267 0.267 rg 304.053 116.850 57.366 0.750 re f 304.053 94.872 57.366 0.750 re f 304.053 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 105.180 Td /F1 9.8 Tf [(13)] TJ ET 0.267 0.267 0.267 rg 360.669 116.850 32.064 0.750 re f 360.669 94.872 32.064 0.750 re f 360.669 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 105.180 Td /F1 9.8 Tf [(1.0)] TJ ET 0.267 0.267 0.267 rg 391.983 116.850 57.366 0.750 re f 391.983 94.872 57.366 0.750 re f 391.983 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 105.180 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 448.598 116.850 38.912 0.750 re f 448.598 94.872 38.912 0.750 re f 448.598 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 105.180 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 486.760 116.850 55.953 0.750 re f 486.760 94.872 55.953 0.750 re f 486.760 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 105.180 Td /F1 9.8 Tf [(13)] TJ ET 0.267 0.267 0.267 rg 541.963 116.850 38.912 0.750 re f 541.963 94.872 38.912 0.750 re f 541.963 94.872 0.750 22.728 re f 580.125 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 105.180 Td /F1 9.8 Tf [(1.0)] TJ ET Q q 15.000 95.247 577.500 681.753 re W n q 26.250 759.180 555.000 17.820 re W n 0.271 0.267 0.267 rg BT 26.250 762.744 Td /F1 9.8 Tf [(Summary of all studies used in this analysis)] TJ ET Q 0.965 0.965 0.965 rg 26.250 712.086 555.000 39.594 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 751.680 m 581.250 751.680 l 580.500 750.930 l 27.000 750.930 l f 581.250 751.680 m 581.250 712.086 l 580.500 712.086 l 580.500 750.930 l f 26.250 751.680 m 26.250 712.086 l 27.000 712.086 l 27.000 750.930 l f 0.271 0.267 0.267 rg BT 33.000 734.792 Td /F1 9.0 Tf [(* refers to studies included in the original Hayden study)] TJ ET 0.267 0.267 0.267 rg BT 285.477 735.330 Td /F4 8.0 Tf [(11)] TJ ET 0.271 0.267 0.267 rg BT 296.613 734.792 Td /F1 9.0 Tf [( The paper from Pleydell 1954)] TJ ET 0.267 0.267 0.267 rg BT 435.789 735.330 Td /F4 8.0 Tf [(26)] TJ ET 0.271 0.267 0.267 rg BT 446.925 734.792 Td /F1 9.0 Tf [(was included with )] TJ ET BT 33.000 722.120 Td /F1 9.0 Tf [(additional data from Pleydell 1955)] TJ ET 0.267 0.267 0.267 rg BT 188.520 722.658 Td /F4 8.0 Tf [(27)] TJ ET 0.271 0.267 0.267 rg BT 199.656 722.120 Td /F1 9.0 Tf [( - means there was no furher specification of age)] TJ ET 1.000 1.000 1.000 rg 26.250 95.247 555.000 616.839 re f 0.965 0.965 0.965 rg 27.000 680.073 81.234 31.263 re f 0.267 0.267 0.267 rg 26.625 710.961 81.609 0.750 re f 26.625 679.698 0.750 32.013 re f 0.271 0.267 0.267 rg BT 31.500 698.981 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 108.234 680.073 70.068 31.263 re f 0.267 0.267 0.267 rg 108.234 710.961 70.068 0.750 re f 0.271 0.267 0.267 rg BT 112.734 698.981 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 178.302 680.073 79.835 31.263 re f 0.267 0.267 0.267 rg 178.302 710.961 79.835 0.750 re f 0.271 0.267 0.267 rg BT 182.802 698.981 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 258.136 680.073 46.292 31.263 re f 0.267 0.267 0.267 rg 258.136 710.961 46.292 0.750 re f 0.271 0.267 0.267 rg BT 262.636 698.981 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 304.428 680.073 56.616 31.263 re f 0.267 0.267 0.267 rg 304.428 710.961 56.616 0.750 re f 0.271 0.267 0.267 rg BT 308.928 698.981 Td /F4 9.8 Tf [(0 -10 )] TJ ET BT 308.928 683.537 Td /F4 9.8 Tf [(years)] TJ ET 0.965 0.965 0.965 rg 361.044 680.073 31.314 31.263 re f 0.267 0.267 0.267 rg 361.044 710.961 31.314 0.750 re f 0.271 0.267 0.267 rg BT 365.544 698.981 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 392.358 680.073 56.616 31.263 re f 0.267 0.267 0.267 rg 392.358 710.961 56.616 0.750 re f 0.271 0.267 0.267 rg BT 396.858 698.981 Td /F4 9.8 Tf [(11-20 )] TJ ET BT 396.858 683.537 Td /F4 9.8 Tf [(years)] TJ ET 0.965 0.965 0.965 rg 448.973 680.073 38.162 31.263 re f 0.267 0.267 0.267 rg 448.973 710.961 38.162 0.750 re f 0.271 0.267 0.267 rg BT 453.473 698.981 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 487.135 680.073 55.203 31.263 re f 0.267 0.267 0.267 rg 487.135 710.961 55.203 0.750 re f 0.271 0.267 0.267 rg BT 491.635 698.981 Td /F4 9.8 Tf [(Total )] TJ ET BT 491.635 683.537 Td /F4 9.8 Tf [(JHD)] TJ ET 0.965 0.965 0.965 rg 542.338 680.073 38.162 31.263 re f 0.267 0.267 0.267 rg 542.338 710.961 38.537 0.750 re f 580.125 679.698 0.750 32.013 re f 0.271 0.267 0.267 rg BT 546.838 698.981 Td /F4 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 26.625 679.698 81.984 0.750 re f 26.625 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 31.875 668.028 Td /F1 9.8 Tf [(Authors)] TJ ET 0.267 0.267 0.267 rg 107.859 679.698 70.818 0.750 re f 107.859 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 113.109 668.028 Td /F1 9.8 Tf [(Publication)] TJ ET BT 113.109 658.128 Td /F1 9.8 Tf [(year)] TJ ET 0.267 0.267 0.267 rg 177.927 679.698 80.585 0.750 re f 177.927 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 183.177 668.028 Td /F1 9.8 Tf [(Location)] TJ ET 0.267 0.267 0.267 rg 257.761 679.698 47.042 0.750 re f 257.761 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 263.011 668.028 Td /F1 9.8 Tf [(Total )] TJ ET BT 263.011 658.128 Td /F1 9.8 Tf [(HD )] TJ ET BT 263.011 648.228 Td /F1 9.8 Tf [(cases)] TJ ET 0.267 0.267 0.267 rg 304.053 679.698 57.366 0.750 re f 304.053 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 309.303 668.028 Td /F1 9.8 Tf [(Number)] TJ ET 0.267 0.267 0.267 rg 360.669 679.698 32.064 0.750 re f 360.669 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 365.919 668.028 Td /F1 9.8 Tf [(%)] TJ ET 0.267 0.267 0.267 rg 391.983 679.698 57.366 0.750 re f 391.983 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 397.233 668.028 Td /F1 9.8 Tf [(Number)] TJ ET 0.267 0.267 0.267 rg 448.598 679.698 38.912 0.750 re f 448.598 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 453.848 668.028 Td /F1 9.8 Tf [(%)] TJ ET 0.267 0.267 0.267 rg 486.760 679.698 55.953 0.750 re f 486.760 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 492.010 668.028 Td /F1 9.8 Tf [(Number)] TJ ET 0.267 0.267 0.267 rg 541.963 679.698 38.912 0.750 re f 541.963 641.748 0.750 38.700 re f 580.125 641.748 0.750 38.700 re f 0.271 0.267 0.267 rg BT 547.213 668.028 Td /F1 9.8 Tf [(%)] TJ ET 0.267 0.267 0.267 rg 26.625 641.748 81.984 0.750 re f 26.625 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 630.078 Td /F1 9.8 Tf [(*Davenport )] TJ ET BT 31.875 617.116 Td /F1 9.8 Tf [(& Muncey)] TJ ET 0.267 0.267 0.267 rg BT 80.489 617.698 Td /F4 8.7 Tf [(29)] TJ ET 0.271 0.267 0.267 rg BT 92.553 617.116 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 641.748 70.818 0.750 re f 107.859 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 630.078 Td /F1 9.8 Tf [(1916)] TJ ET 0.267 0.267 0.267 rg 177.927 641.748 80.585 0.750 re f 177.927 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 630.078 Td /F1 9.8 Tf [(USA)] TJ ET 0.267 0.267 0.267 rg 257.761 641.748 47.042 0.750 re f 257.761 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 630.078 Td /F1 9.8 Tf [(138)] TJ ET 0.267 0.267 0.267 rg 304.053 641.748 57.366 0.750 re f 304.053 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 630.078 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 360.669 641.748 32.064 0.750 re f 360.669 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 630.078 Td /F1 9.8 Tf [(2.2)] TJ ET 0.267 0.267 0.267 rg 391.983 641.748 57.366 0.750 re f 391.983 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 630.078 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 448.598 641.748 38.912 0.750 re f 448.598 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 630.078 Td /F1 9.8 Tf [(1.4)] TJ ET 0.267 0.267 0.267 rg 486.760 641.748 55.953 0.750 re f 486.760 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 630.078 Td /F1 9.8 Tf [(5)] TJ ET 0.267 0.267 0.267 rg 541.963 641.748 38.912 0.750 re f 541.963 609.870 0.750 32.628 re f 580.125 609.870 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 630.078 Td /F1 9.8 Tf [(3.6)] TJ ET 0.267 0.267 0.267 rg 26.625 609.870 81.984 0.750 re f 26.625 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 598.200 Td /F1 9.8 Tf [(*Spillane &)] TJ ET BT 31.875 585.238 Td /F1 9.8 Tf [(Phillips)] TJ ET 0.267 0.267 0.267 rg BT 66.049 585.820 Td /F4 8.7 Tf [(30)] TJ ET 0.271 0.267 0.267 rg BT 78.113 585.238 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 609.870 70.818 0.750 re f 107.859 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 598.200 Td /F1 9.8 Tf [(1937)] TJ ET 0.267 0.267 0.267 rg 177.927 609.870 80.585 0.750 re f 177.927 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 598.200 Td /F1 9.8 Tf [(South )] TJ ET BT 183.177 588.300 Td /F1 9.8 Tf [(Wales)] TJ ET 0.267 0.267 0.267 rg 257.761 609.870 47.042 0.750 re f 257.761 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 598.200 Td /F1 9.8 Tf [(21)] TJ ET 0.267 0.267 0.267 rg 304.053 609.870 57.366 0.750 re f 304.053 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 598.200 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 609.870 32.064 0.750 re f 360.669 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 598.200 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 609.870 57.366 0.750 re f 391.983 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 598.200 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 448.598 609.870 38.912 0.750 re f 448.598 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 598.200 Td /F1 9.8 Tf [(9.5)] TJ ET 0.267 0.267 0.267 rg 486.760 609.870 55.953 0.750 re f 486.760 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 598.200 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 541.963 609.870 38.912 0.750 re f 541.963 577.992 0.750 32.628 re f 580.125 577.992 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 598.200 Td /F1 9.8 Tf [(9.5)] TJ ET 0.267 0.267 0.267 rg 26.625 577.992 81.984 0.750 re f 26.625 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 563.260 Td /F1 9.8 Tf [(*Panse)] TJ ET 0.267 0.267 0.267 rg BT 68.964 563.842 Td /F4 8.7 Tf [(20)] TJ ET 0.271 0.267 0.267 rg BT 81.028 563.260 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 577.992 70.818 0.750 re f 107.859 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 566.322 Td /F1 9.8 Tf [(1942)] TJ ET 0.267 0.267 0.267 rg 177.927 577.992 80.585 0.750 re f 177.927 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 566.322 Td /F1 9.8 Tf [(Germany)] TJ ET 0.267 0.267 0.267 rg 257.761 577.992 47.042 0.750 re f 257.761 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 566.322 Td /F1 9.8 Tf [(446)] TJ ET 0.267 0.267 0.267 rg 304.053 577.992 57.366 0.750 re f 304.053 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 566.322 Td /F1 9.8 Tf [(7)] TJ ET 0.267 0.267 0.267 rg 360.669 577.992 32.064 0.750 re f 360.669 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 566.322 Td /F1 9.8 Tf [(1.6)] TJ ET 0.267 0.267 0.267 rg 391.983 577.992 57.366 0.750 re f 391.983 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 566.322 Td /F1 9.8 Tf [(17)] TJ ET 0.267 0.267 0.267 rg 448.598 577.992 38.912 0.750 re f 448.598 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 566.322 Td /F1 9.8 Tf [(3.8)] TJ ET 0.267 0.267 0.267 rg 486.760 577.992 55.953 0.750 re f 486.760 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 566.322 Td /F1 9.8 Tf [(24)] TJ ET 0.267 0.267 0.267 rg 541.963 577.992 38.912 0.750 re f 541.963 556.014 0.750 22.728 re f 580.125 556.014 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 566.322 Td /F1 9.8 Tf [(5.4)] TJ ET 0.267 0.267 0.267 rg 26.625 556.014 81.984 0.750 re f 26.625 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 541.282 Td /F1 9.8 Tf [(Pleydell)] TJ ET 0.267 0.267 0.267 rg BT 72.942 541.864 Td /F4 8.7 Tf [(26)] TJ ET 0.271 0.267 0.267 rg BT 85.006 541.282 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 556.014 70.818 0.750 re f 107.859 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 544.344 Td /F1 9.8 Tf [(1954)] TJ ET 0.267 0.267 0.267 rg 177.927 556.014 80.585 0.750 re f 177.927 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 544.344 Td /F1 9.8 Tf [(England)] TJ ET 0.267 0.267 0.267 rg 257.761 556.014 47.042 0.750 re f 257.761 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 544.344 Td /F1 9.8 Tf [(17)] TJ ET 0.267 0.267 0.267 rg 304.053 556.014 57.366 0.750 re f 304.053 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 544.344 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 556.014 32.064 0.750 re f 360.669 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 544.344 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 556.014 57.366 0.750 re f 391.983 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 544.344 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 448.598 556.014 38.912 0.750 re f 448.598 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 544.344 Td /F1 9.8 Tf [(11.8)] TJ ET 0.267 0.267 0.267 rg 486.760 556.014 55.953 0.750 re f 486.760 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 544.344 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 541.963 556.014 38.912 0.750 re f 541.963 534.036 0.750 22.728 re f 580.125 534.036 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 544.344 Td /F1 9.8 Tf [(11.8)] TJ ET 0.267 0.267 0.267 rg 26.625 534.036 81.984 0.750 re f 26.625 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 522.366 Td /F1 9.8 Tf [(*Reed )] TJ ET BT 31.875 509.404 Td /F1 9.8 Tf [(et al)] TJ ET 0.267 0.267 0.267 rg BT 53.481 509.986 Td /F4 8.7 Tf [(18)] TJ ET 0.271 0.267 0.267 rg BT 65.545 509.404 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 534.036 70.818 0.750 re f 107.859 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 522.366 Td /F1 9.8 Tf [(1958)] TJ ET 0.267 0.267 0.267 rg 177.927 534.036 80.585 0.750 re f 177.927 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 522.366 Td /F1 9.8 Tf [(USA)] TJ ET 0.267 0.267 0.267 rg 257.761 534.036 47.042 0.750 re f 257.761 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 522.366 Td /F1 9.8 Tf [(203)] TJ ET 0.267 0.267 0.267 rg 304.053 534.036 57.366 0.750 re f 304.053 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 522.366 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 534.036 32.064 0.750 re f 360.669 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 522.366 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 534.036 57.366 0.750 re f 391.983 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 522.366 Td /F1 9.8 Tf [(12)] TJ ET 0.267 0.267 0.267 rg 448.598 534.036 38.912 0.750 re f 448.598 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 522.366 Td /F1 9.8 Tf [(5.9)] TJ ET 0.267 0.267 0.267 rg 486.760 534.036 55.953 0.750 re f 486.760 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 522.366 Td /F1 9.8 Tf [(12)] TJ ET 0.267 0.267 0.267 rg 541.963 534.036 38.912 0.750 re f 541.963 502.158 0.750 32.628 re f 580.125 502.158 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 522.366 Td /F1 9.8 Tf [(5.9)] TJ ET 0.267 0.267 0.267 rg 26.625 502.158 81.984 0.750 re f 26.625 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 487.426 Td /F1 9.8 Tf [(*Brothers)] TJ ET 0.267 0.267 0.267 rg BT 78.499 488.008 Td /F4 8.7 Tf [(31)] TJ ET 0.271 0.267 0.267 rg BT 90.564 487.426 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 502.158 70.818 0.750 re f 107.859 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 490.488 Td /F1 9.8 Tf [(1964)] TJ ET 0.267 0.267 0.267 rg 177.927 502.158 80.585 0.750 re f 177.927 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 490.488 Td /F1 9.8 Tf [(Australia)] TJ ET 0.267 0.267 0.267 rg 257.761 502.158 47.042 0.750 re f 257.761 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 490.488 Td /F1 9.8 Tf [(206)] TJ ET 0.267 0.267 0.267 rg 304.053 502.158 57.366 0.750 re f 304.053 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 490.488 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 360.669 502.158 32.064 0.750 re f 360.669 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 490.488 Td /F1 9.8 Tf [(1.9)] TJ ET 0.267 0.267 0.267 rg 391.983 502.158 57.366 0.750 re f 391.983 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 490.488 Td /F1 9.8 Tf [(11)] TJ ET 0.267 0.267 0.267 rg 448.598 502.158 38.912 0.750 re f 448.598 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 490.488 Td /F1 9.8 Tf [(5.3)] TJ ET 0.267 0.267 0.267 rg 486.760 502.158 55.953 0.750 re f 486.760 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 490.488 Td /F1 9.8 Tf [(15)] TJ ET 0.267 0.267 0.267 rg 541.963 502.158 38.912 0.750 re f 541.963 480.180 0.750 22.728 re f 580.125 480.180 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 490.488 Td /F1 9.8 Tf [(7.3)] TJ ET 0.267 0.267 0.267 rg 26.625 480.180 81.984 0.750 re f 26.625 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 468.510 Td /F1 9.8 Tf [(*Cameron )] TJ ET BT 31.875 455.548 Td /F1 9.8 Tf [(& Venters)] TJ ET 0.267 0.267 0.267 rg BT 80.333 456.130 Td /F4 8.7 Tf [(24)] TJ ET 0.271 0.267 0.267 rg BT 92.397 455.548 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 480.180 70.818 0.750 re f 107.859 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 468.510 Td /F1 9.8 Tf [(1967)] TJ ET 0.267 0.267 0.267 rg 177.927 480.180 80.585 0.750 re f 177.927 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 468.510 Td /F1 9.8 Tf [(Scotland)] TJ ET 0.267 0.267 0.267 rg 257.761 480.180 47.042 0.750 re f 257.761 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 468.510 Td /F1 9.8 Tf [(143)] TJ ET 0.267 0.267 0.267 rg 304.053 480.180 57.366 0.750 re f 304.053 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 468.510 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 480.180 32.064 0.750 re f 360.669 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 468.510 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 480.180 57.366 0.750 re f 391.983 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 468.510 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 480.180 38.912 0.750 re f 448.598 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 468.510 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 480.180 55.953 0.750 re f 486.760 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 468.510 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 541.963 480.180 38.912 0.750 re f 541.963 448.302 0.750 32.628 re f 580.125 448.302 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 468.510 Td /F1 9.8 Tf [(21)] TJ ET 0.267 0.267 0.267 rg 26.625 448.302 81.984 0.750 re f 26.625 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 433.570 Td /F1 9.8 Tf [(*Heathfield)] TJ ET 0.267 0.267 0.267 rg BT 90.200 434.152 Td /F4 8.7 Tf [(32)] TJ ET 0.271 0.267 0.267 rg BT 31.875 422.904 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 448.302 70.818 0.750 re f 107.859 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 436.632 Td /F1 9.8 Tf [(1967)] TJ ET 0.267 0.267 0.267 rg 177.927 448.302 80.585 0.750 re f 177.927 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 436.632 Td /F1 9.8 Tf [(England)] TJ ET 0.267 0.267 0.267 rg 257.761 448.302 47.042 0.750 re f 257.761 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 436.632 Td /F1 9.8 Tf [(81)] TJ ET 0.267 0.267 0.267 rg 304.053 448.302 57.366 0.750 re f 304.053 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 436.632 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 448.302 32.064 0.750 re f 360.669 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 436.632 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 448.302 57.366 0.750 re f 391.983 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 436.632 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 448.598 448.302 38.912 0.750 re f 448.598 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 436.632 Td /F1 9.8 Tf [(2.5)] TJ ET 0.267 0.267 0.267 rg 486.760 448.302 55.953 0.750 re f 486.760 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 436.632 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 541.963 448.302 38.912 0.750 re f 541.963 416.424 0.750 32.628 re f 580.125 416.424 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 436.632 Td /F1 9.8 Tf [(2.5)] TJ ET 0.267 0.267 0.267 rg 26.625 416.424 81.984 0.750 re f 26.625 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 401.692 Td /F1 9.8 Tf [(*Oliver)] TJ ET 0.267 0.267 0.267 rg BT 65.620 402.274 Td /F4 8.7 Tf [(33)] TJ ET 0.271 0.267 0.267 rg BT 77.684 401.692 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 416.424 70.818 0.750 re f 107.859 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 404.754 Td /F1 9.8 Tf [(1970)] TJ ET 0.267 0.267 0.267 rg 177.927 416.424 80.585 0.750 re f 177.927 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 404.754 Td /F1 9.8 Tf [(England)] TJ ET 0.267 0.267 0.267 rg 257.761 416.424 47.042 0.750 re f 257.761 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 404.754 Td /F1 9.8 Tf [(115)] TJ ET 0.267 0.267 0.267 rg 304.053 416.424 57.366 0.750 re f 304.053 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 404.754 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 360.669 416.424 32.064 0.750 re f 360.669 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 404.754 Td /F1 9.8 Tf [(3.5)] TJ ET 0.267 0.267 0.267 rg 391.983 416.424 57.366 0.750 re f 391.983 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 404.754 Td /F1 9.8 Tf [(7)] TJ ET 0.267 0.267 0.267 rg 448.598 416.424 38.912 0.750 re f 448.598 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 404.754 Td /F1 9.8 Tf [(6.1)] TJ ET 0.267 0.267 0.267 rg 486.760 416.424 55.953 0.750 re f 486.760 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 404.754 Td /F1 9.8 Tf [(11)] TJ ET 0.267 0.267 0.267 rg 541.963 416.424 38.912 0.750 re f 541.963 394.446 0.750 22.728 re f 580.125 394.446 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 404.754 Td /F1 9.8 Tf [(9.6)] TJ ET 0.267 0.267 0.267 rg 26.625 394.446 81.984 0.750 re f 26.625 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 379.714 Td /F1 9.8 Tf [(*Mattsson)] TJ ET 0.267 0.267 0.267 rg BT 84.194 380.296 Td /F4 8.7 Tf [(34)] TJ ET 0.271 0.267 0.267 rg BT 96.258 379.714 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 394.446 70.818 0.750 re f 107.859 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 382.776 Td /F1 9.8 Tf [(1974)] TJ ET 0.267 0.267 0.267 rg 177.927 394.446 80.585 0.750 re f 177.927 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 382.776 Td /F1 9.8 Tf [(Sweden)] TJ ET 0.267 0.267 0.267 rg 257.761 394.446 47.042 0.750 re f 257.761 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 382.776 Td /F1 9.8 Tf [(362)] TJ ET 0.267 0.267 0.267 rg 304.053 394.446 57.366 0.750 re f 304.053 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 382.776 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 394.446 32.064 0.750 re f 360.669 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 382.776 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 394.446 57.366 0.750 re f 391.983 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 382.776 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 394.446 38.912 0.750 re f 448.598 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 382.776 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 394.446 55.953 0.750 re f 486.760 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 382.776 Td /F1 9.8 Tf [(17)] TJ ET 0.267 0.267 0.267 rg 541.963 394.446 38.912 0.750 re f 541.963 372.468 0.750 22.728 re f 580.125 372.468 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 382.776 Td /F1 9.8 Tf [(4.7)] TJ ET 0.267 0.267 0.267 rg 26.625 372.468 81.984 0.750 re f 26.625 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 357.736 Td /F1 9.8 Tf [(*Stevens)] TJ ET 0.267 0.267 0.267 rg BT 78.889 358.318 Td /F4 8.7 Tf [(35)] TJ ET 0.271 0.267 0.267 rg BT 90.954 357.736 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 372.468 70.818 0.750 re f 107.859 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 360.798 Td /F1 9.8 Tf [(1976)] TJ ET 0.267 0.267 0.267 rg 177.927 372.468 80.585 0.750 re f 177.927 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 360.798 Td /F1 9.8 Tf [(England)] TJ ET 0.267 0.267 0.267 rg 257.761 372.468 47.042 0.750 re f 257.761 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 360.798 Td /F1 9.8 Tf [(133)] TJ ET 0.267 0.267 0.267 rg 304.053 372.468 57.366 0.750 re f 304.053 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 360.798 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 372.468 32.064 0.750 re f 360.669 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 360.798 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 391.983 372.468 57.366 0.750 re f 391.983 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 360.798 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 448.598 372.468 38.912 0.750 re f 448.598 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 360.798 Td /F1 9.8 Tf [(0.8)] TJ ET 0.267 0.267 0.267 rg 486.760 372.468 55.953 0.750 re f 486.760 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 360.798 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 541.963 372.468 38.912 0.750 re f 541.963 350.490 0.750 22.728 re f 580.125 350.490 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 360.798 Td /F1 9.8 Tf [(0.8)] TJ ET 0.267 0.267 0.267 rg 26.625 350.490 81.984 0.750 re f 26.625 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 338.820 Td /F1 9.8 Tf [(Walker et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 326.440 Td /F4 8.7 Tf [(36)] TJ ET 0.271 0.267 0.267 rg BT 43.939 325.858 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 350.490 70.818 0.750 re f 107.859 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 338.820 Td /F1 9.8 Tf [(1981)] TJ ET 0.267 0.267 0.267 rg 177.927 350.490 80.585 0.750 re f 177.927 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 338.820 Td /F1 9.8 Tf [(South)] TJ ET BT 183.177 328.920 Td /F1 9.8 Tf [(Wales)] TJ ET 0.267 0.267 0.267 rg 257.761 350.490 47.042 0.750 re f 257.761 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 338.820 Td /F1 9.8 Tf [(333)] TJ ET 0.267 0.267 0.267 rg 304.053 350.490 57.366 0.750 re f 304.053 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 338.820 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 360.669 350.490 32.064 0.750 re f 360.669 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 338.820 Td /F1 9.8 Tf [(0.9)] TJ ET 0.267 0.267 0.267 rg 391.983 350.490 57.366 0.750 re f 391.983 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 338.820 Td /F1 9.8 Tf [(11)] TJ ET 0.267 0.267 0.267 rg 448.598 350.490 38.912 0.750 re f 448.598 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 338.820 Td /F1 9.8 Tf [(3.3)] TJ ET 0.267 0.267 0.267 rg 486.760 350.490 55.953 0.750 re f 486.760 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 338.820 Td /F1 9.8 Tf [(14)] TJ ET 0.267 0.267 0.267 rg 541.963 350.490 38.912 0.750 re f 541.963 318.612 0.750 32.628 re f 580.125 318.612 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 338.820 Td /F1 9.8 Tf [(4.2)] TJ ET 0.267 0.267 0.267 rg 26.625 318.612 81.984 0.750 re f 26.625 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 306.942 Td /F1 9.8 Tf [(*Hayden et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 294.562 Td /F4 8.7 Tf [(28)] TJ ET 0.271 0.267 0.267 rg BT 43.939 293.980 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 318.612 70.818 0.750 re f 107.859 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 306.942 Td /F1 9.8 Tf [(1982)] TJ ET 0.267 0.267 0.267 rg 177.927 318.612 80.585 0.750 re f 177.927 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 306.942 Td /F1 9.8 Tf [(S Africa )] TJ ET BT 183.177 297.042 Td /F1 9.8 Tf [(Total)] TJ ET 0.267 0.267 0.267 rg 257.761 318.612 47.042 0.750 re f 257.761 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 306.942 Td /F1 9.8 Tf [(219)] TJ ET 0.267 0.267 0.267 rg 304.053 318.612 57.366 0.750 re f 304.053 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 306.942 Td /F1 9.8 Tf [(6)] TJ ET 0.267 0.267 0.267 rg 360.669 318.612 32.064 0.750 re f 360.669 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 306.942 Td /F1 9.8 Tf [(2.7)] TJ ET 0.267 0.267 0.267 rg 391.983 318.612 57.366 0.750 re f 391.983 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 306.942 Td /F1 9.8 Tf [(11)] TJ ET 0.267 0.267 0.267 rg 448.598 318.612 38.912 0.750 re f 448.598 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 306.942 Td /F1 9.8 Tf [(5)] TJ ET 0.267 0.267 0.267 rg 486.760 318.612 55.953 0.750 re f 486.760 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 306.942 Td /F1 9.8 Tf [(17)] TJ ET 0.267 0.267 0.267 rg 541.963 318.612 38.912 0.750 re f 541.963 286.734 0.750 32.628 re f 580.125 286.734 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 306.942 Td /F1 9.8 Tf [(7.7)] TJ ET 0.267 0.267 0.267 rg 26.625 286.734 81.984 0.750 re f 26.625 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 31.875 275.064 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 286.734 70.818 0.750 re f 107.859 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 113.109 275.064 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 177.927 286.734 80.585 0.750 re f 177.927 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 183.177 275.064 Td /F1 9.8 Tf [(S Africa)] TJ ET BT 183.177 265.164 Td /F1 9.8 Tf [(Whites)] TJ ET 0.267 0.267 0.267 rg 257.761 286.734 47.042 0.750 re f 257.761 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 263.011 275.064 Td /F1 9.8 Tf [(147)] TJ ET 0.267 0.267 0.267 rg 304.053 286.734 57.366 0.750 re f 304.053 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 309.303 275.064 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 360.669 286.734 32.064 0.750 re f 360.669 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 365.919 275.064 Td /F1 9.8 Tf [(2.0)] TJ ET 0.267 0.267 0.267 rg 391.983 286.734 57.366 0.750 re f 391.983 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 397.233 275.064 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 448.598 286.734 38.912 0.750 re f 448.598 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 453.848 275.064 Td /F1 9.8 Tf [(2.0)] TJ ET 0.267 0.267 0.267 rg 486.760 286.734 55.953 0.750 re f 486.760 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 492.010 275.064 Td /F1 9.8 Tf [(6)] TJ ET 0.267 0.267 0.267 rg 541.963 286.734 38.912 0.750 re f 541.963 258.684 0.750 28.800 re f 580.125 258.684 0.750 28.800 re f 0.271 0.267 0.267 rg BT 547.213 275.064 Td /F1 9.8 Tf [(4.1)] TJ ET 0.267 0.267 0.267 rg 26.625 258.684 81.984 0.750 re f 26.625 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 31.875 247.014 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 258.684 70.818 0.750 re f 107.859 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 113.109 247.014 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 177.927 258.684 80.585 0.750 re f 177.927 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 183.177 247.014 Td /F1 9.8 Tf [(S Africa )] TJ ET BT 183.177 237.114 Td /F1 9.8 Tf [(Mixed)] TJ ET 0.267 0.267 0.267 rg 257.761 258.684 47.042 0.750 re f 257.761 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 263.011 247.014 Td /F1 9.8 Tf [(72)] TJ ET 0.267 0.267 0.267 rg 304.053 258.684 57.366 0.750 re f 304.053 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 309.303 247.014 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 360.669 258.684 32.064 0.750 re f 360.669 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 365.919 247.014 Td /F1 9.8 Tf [(4.2)] TJ ET 0.267 0.267 0.267 rg 391.983 258.684 57.366 0.750 re f 391.983 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 397.233 247.014 Td /F1 9.8 Tf [(8)] TJ ET 0.267 0.267 0.267 rg 448.598 258.684 38.912 0.750 re f 448.598 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 453.848 247.014 Td /F1 9.8 Tf [(11.1)] TJ ET 0.267 0.267 0.267 rg 486.760 258.684 55.953 0.750 re f 486.760 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 492.010 247.014 Td /F1 9.8 Tf [(11)] TJ ET 0.267 0.267 0.267 rg 541.963 258.684 38.912 0.750 re f 541.963 230.634 0.750 28.800 re f 580.125 230.634 0.750 28.800 re f 0.271 0.267 0.267 rg BT 547.213 247.014 Td /F1 9.8 Tf [(15.3)] TJ ET 0.267 0.267 0.267 rg 26.625 230.634 81.984 0.750 re f 26.625 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 31.875 218.964 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 230.634 70.818 0.750 re f 107.859 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 113.109 218.964 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 177.927 230.634 80.585 0.750 re f 177.927 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 183.177 218.964 Td /F1 9.8 Tf [(S Africa)] TJ ET BT 183.177 209.064 Td /F1 9.8 Tf [(Blacks)] TJ ET 0.267 0.267 0.267 rg 257.761 230.634 47.042 0.750 re f 257.761 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 263.011 218.964 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 304.053 230.634 57.366 0.750 re f 304.053 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 309.303 218.964 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 360.669 230.634 32.064 0.750 re f 360.669 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 365.919 218.964 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 391.983 230.634 57.366 0.750 re f 391.983 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 397.233 218.964 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 448.598 230.634 38.912 0.750 re f 448.598 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 453.848 218.964 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 486.760 230.634 55.953 0.750 re f 486.760 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 492.010 218.964 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 541.963 230.634 38.912 0.750 re f 541.963 202.584 0.750 28.800 re f 580.125 202.584 0.750 28.800 re f 0.271 0.267 0.267 rg BT 547.213 218.964 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 26.625 202.584 81.984 0.750 re f 26.625 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 187.852 Td /F1 9.8 Tf [(Myers et al)] TJ ET 0.267 0.267 0.267 rg BT 88.952 188.434 Td /F4 8.7 Tf [(37)] TJ ET 0.271 0.267 0.267 rg BT 31.875 177.186 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 202.584 70.818 0.750 re f 107.859 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 190.914 Td /F1 9.8 Tf [(1982)] TJ ET 0.267 0.267 0.267 rg 177.927 202.584 80.585 0.750 re f 177.927 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 190.914 Td /F1 9.8 Tf [(USA)] TJ ET 0.267 0.267 0.267 rg 257.761 202.584 47.042 0.750 re f 257.761 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 190.914 Td /F1 9.8 Tf [(83)] TJ ET 0.267 0.267 0.267 rg 304.053 202.584 57.366 0.750 re f 304.053 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 190.914 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 360.669 202.584 32.064 0.750 re f 360.669 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 190.914 Td /F1 9.8 Tf [(2.4)] TJ ET 0.267 0.267 0.267 rg 391.983 202.584 57.366 0.750 re f 391.983 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 190.914 Td /F1 9.8 Tf [(7)] TJ ET 0.267 0.267 0.267 rg 448.598 202.584 38.912 0.750 re f 448.598 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 190.914 Td /F1 9.8 Tf [(8.4)] TJ ET 0.267 0.267 0.267 rg 486.760 202.584 55.953 0.750 re f 486.760 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 190.914 Td /F1 9.8 Tf [(9)] TJ ET 0.267 0.267 0.267 rg 541.963 202.584 38.912 0.750 re f 541.963 170.706 0.750 32.628 re f 580.125 170.706 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 190.914 Td /F1 9.8 Tf [(10.8)] TJ ET 0.267 0.267 0.267 rg 26.625 170.706 81.984 0.750 re f 26.625 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 155.974 Td /F1 9.8 Tf [(Went et al)] TJ ET 0.267 0.267 0.267 rg BT 85.325 156.556 Td /F4 8.7 Tf [(38)] TJ ET 0.271 0.267 0.267 rg BT 97.389 155.974 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 170.706 70.818 0.750 re f 107.859 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 159.036 Td /F1 9.8 Tf [(1983)] TJ ET 0.267 0.267 0.267 rg 177.927 170.706 80.585 0.750 re f 177.927 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 159.036 Td /F1 9.8 Tf [(Netherlands)] TJ ET 0.267 0.267 0.267 rg 257.761 170.706 47.042 0.750 re f 257.761 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 159.036 Td /F1 9.8 Tf [(276)] TJ ET 0.267 0.267 0.267 rg 304.053 170.706 57.366 0.750 re f 304.053 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 159.036 Td /F1 9.8 Tf [(5)] TJ ET 0.267 0.267 0.267 rg 360.669 170.706 32.064 0.750 re f 360.669 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 159.036 Td /F1 9.8 Tf [(81.)] TJ ET 0.267 0.267 0.267 rg 391.983 170.706 57.366 0.750 re f 391.983 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 159.036 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 448.598 170.706 38.912 0.750 re f 448.598 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 159.036 Td /F1 9.8 Tf [(1.1)] TJ ET 0.267 0.267 0.267 rg 486.760 170.706 55.953 0.750 re f 486.760 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 159.036 Td /F1 9.8 Tf [(8)] TJ ET 0.267 0.267 0.267 rg 541.963 170.706 38.912 0.750 re f 541.963 148.728 0.750 22.728 re f 580.125 148.728 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 159.036 Td /F1 9.8 Tf [(2.9)] TJ ET 0.267 0.267 0.267 rg 26.625 148.728 81.984 0.750 re f 26.625 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 137.058 Td /F1 9.8 Tf [(Di Maio et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 124.678 Td /F4 8.7 Tf [(39)] TJ ET 0.271 0.267 0.267 rg BT 43.939 124.096 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 148.728 70.818 0.750 re f 107.859 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 137.058 Td /F1 9.8 Tf [(1984)] TJ ET 0.267 0.267 0.267 rg 177.927 148.728 80.585 0.750 re f 177.927 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 137.058 Td /F1 9.8 Tf [(Italy)] TJ ET 0.267 0.267 0.267 rg 257.761 148.728 47.042 0.750 re f 257.761 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 137.058 Td /F1 9.8 Tf [(95)] TJ ET 0.267 0.267 0.267 rg 304.053 148.728 57.366 0.750 re f 304.053 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 137.058 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 148.728 32.064 0.750 re f 360.669 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 137.058 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 148.728 57.366 0.750 re f 391.983 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 137.058 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 148.728 38.912 0.750 re f 448.598 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 137.058 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 148.728 55.953 0.750 re f 486.760 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 137.058 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 541.963 148.728 38.912 0.750 re f 541.963 116.850 0.750 32.628 re f 580.125 116.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 137.058 Td /F1 9.8 Tf [(4.2)] TJ ET 0.267 0.267 0.267 rg 26.625 116.850 81.984 0.750 re f 26.625 94.872 81.984 0.750 re f 26.625 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 102.118 Td /F1 9.8 Tf [(Went et al)] TJ ET 0.267 0.267 0.267 rg BT 85.325 102.700 Td /F4 8.7 Tf [(40)] TJ ET 0.271 0.267 0.267 rg BT 97.389 102.118 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 116.850 70.818 0.750 re f 107.859 94.872 70.818 0.750 re f 107.859 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 105.180 Td /F1 9.8 Tf [(1984)] TJ ET 0.267 0.267 0.267 rg 177.927 116.850 80.585 0.750 re f 177.927 94.872 80.585 0.750 re f 177.927 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 105.180 Td /F1 9.8 Tf [(Netherlands)] TJ ET 0.267 0.267 0.267 rg 257.761 116.850 47.042 0.750 re f 257.761 94.872 47.042 0.750 re f 257.761 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 105.180 Td /F1 9.8 Tf [(1246)] TJ ET 0.267 0.267 0.267 rg 304.053 116.850 57.366 0.750 re f 304.053 94.872 57.366 0.750 re f 304.053 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 105.180 Td /F1 9.8 Tf [(13)] TJ ET 0.267 0.267 0.267 rg 360.669 116.850 32.064 0.750 re f 360.669 94.872 32.064 0.750 re f 360.669 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 105.180 Td /F1 9.8 Tf [(1.0)] TJ ET 0.267 0.267 0.267 rg 391.983 116.850 57.366 0.750 re f 391.983 94.872 57.366 0.750 re f 391.983 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 105.180 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 448.598 116.850 38.912 0.750 re f 448.598 94.872 38.912 0.750 re f 448.598 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 105.180 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 486.760 116.850 55.953 0.750 re f 486.760 94.872 55.953 0.750 re f 486.760 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 105.180 Td /F1 9.8 Tf [(13)] TJ ET 0.267 0.267 0.267 rg 541.963 116.850 38.912 0.750 re f 541.963 94.872 38.912 0.750 re f 541.963 94.872 0.750 22.728 re f 580.125 94.872 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 105.180 Td /F1 9.8 Tf [(1.0)] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 18.032 Td /F5 11.0 Tf [(13)] TJ ET BT 25.000 18.032 Td /F5 11.0 Tf [(PLOS Currents Huntington Disease)] TJ ET Q endstream endobj 489 0 obj << /Type /Annot /Subtype /Link /A 490 0 R /Border [0 0 0] /H /I /Rect [ 285.4770 734.3700 296.6130 744.9300 ] >> endobj 490 0 obj << /Type /Action >> endobj 491 0 obj << /Type /Annot /Subtype /Link /A 492 0 R /Border [0 0 0] /H /I /Rect [ 435.7890 734.3700 446.9250 744.9300 ] 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681.606 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 701.814 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 713.484 55.953 0.750 re f 486.760 681.606 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 701.814 Td /F1 9.8 Tf [(89)] TJ ET 0.267 0.267 0.267 rg 541.963 713.484 38.912 0.750 re f 541.963 681.606 0.750 32.628 re f 580.125 681.606 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 701.814 Td /F1 9.8 Tf [(14.9)] TJ ET 0.267 0.267 0.267 rg 26.625 681.606 81.984 0.750 re f 26.625 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 669.936 Td /F1 9.8 Tf [(Groppi et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 657.556 Td /F4 8.7 Tf [(43)] TJ ET 0.271 0.267 0.267 rg BT 43.939 656.974 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 681.606 70.818 0.750 re f 107.859 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 669.936 Td /F1 9.8 Tf [(1986)] TJ ET 0.267 0.267 0.267 rg 177.927 681.606 80.585 0.750 re f 177.927 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 669.936 Td /F1 9.8 Tf [(Italy)] TJ ET 0.267 0.267 0.267 rg 257.761 681.606 47.042 0.750 re f 257.761 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 669.936 Td /F1 9.8 Tf [(48)] TJ ET 0.267 0.267 0.267 rg 304.053 681.606 57.366 0.750 re f 304.053 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 669.936 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 681.606 32.064 0.750 re f 360.669 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 669.936 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 681.606 57.366 0.750 re f 391.983 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 669.936 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 681.606 38.912 0.750 re f 448.598 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 669.936 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 681.606 55.953 0.750 re f 486.760 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 669.936 Td /F1 9.8 Tf [(5)] TJ ET 0.267 0.267 0.267 rg 541.963 681.606 38.912 0.750 re f 541.963 649.728 0.750 32.628 re f 580.125 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 669.936 Td /F1 9.8 Tf [(10.4)] TJ ET 0.267 0.267 0.267 rg 26.625 649.728 81.984 0.750 re f 26.625 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 634.996 Td /F1 9.8 Tf [(Young et al)] TJ ET 0.267 0.267 0.267 rg BT 90.160 635.578 Td /F4 8.7 Tf [(44)] TJ ET 0.271 0.267 0.267 rg BT 31.875 624.330 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 649.728 70.818 0.750 re f 107.859 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 638.058 Td /F1 9.8 Tf [(1986)] TJ ET 0.267 0.267 0.267 rg 177.927 649.728 80.585 0.750 re f 177.927 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 638.058 Td /F1 9.8 Tf [(Venezueala)] TJ ET 0.267 0.267 0.267 rg 257.761 649.728 47.042 0.750 re f 257.761 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 638.058 Td /F1 9.8 Tf [(65)] TJ ET 0.267 0.267 0.267 rg 304.053 649.728 57.366 0.750 re f 304.053 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 638.058 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 360.669 649.728 32.064 0.750 re f 360.669 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 638.058 Td /F1 9.8 Tf [(1.5)] TJ ET 0.267 0.267 0.267 rg 391.983 649.728 57.366 0.750 re f 391.983 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 638.058 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 448.598 649.728 38.912 0.750 re f 448.598 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 638.058 Td /F1 9.8 Tf [(4.6)] TJ ET 0.267 0.267 0.267 rg 486.760 649.728 55.953 0.750 re f 486.760 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 638.058 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 541.963 649.728 38.912 0.750 re f 541.963 617.850 0.750 32.628 re f 580.125 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 638.058 Td /F1 9.8 Tf [(6.2)] TJ ET 0.267 0.267 0.267 rg 26.625 617.850 81.984 0.750 re f 26.625 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 606.180 Td /F1 9.8 Tf [(Folstein et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 593.800 Td /F4 8.7 Tf [(19)] TJ ET 0.271 0.267 0.267 rg BT 43.939 593.218 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 617.850 70.818 0.750 re f 107.859 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 606.180 Td /F1 9.8 Tf [(1987)] TJ ET 0.267 0.267 0.267 rg 177.927 617.850 80.585 0.750 re f 177.927 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 606.180 Td /F1 9.8 Tf [(USA)] TJ ET 0.267 0.267 0.267 rg 257.761 617.850 47.042 0.750 re f 257.761 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 606.180 Td /F1 9.8 Tf [(217)] TJ ET 0.267 0.267 0.267 rg 304.053 617.850 57.366 0.750 re f 304.053 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 606.180 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 617.850 32.064 0.750 re f 360.669 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 606.180 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 617.850 57.366 0.750 re f 391.983 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 606.180 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 617.850 38.912 0.750 re f 448.598 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 606.180 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 617.850 55.953 0.750 re f 486.760 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 606.180 Td /F1 9.8 Tf [(15)] TJ ET 0.267 0.267 0.267 rg 541.963 617.850 38.912 0.750 re f 541.963 585.972 0.750 32.628 re f 580.125 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 606.180 Td /F1 9.8 Tf [(6.9)] TJ ET 0.267 0.267 0.267 rg 26.625 585.972 81.984 0.750 re f 26.625 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 574.302 Td /F1 9.8 Tf [(Adams et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 561.922 Td /F4 8.7 Tf [(45)] TJ ET 0.271 0.267 0.267 rg BT 43.939 561.340 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 585.972 70.818 0.750 re f 107.859 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 574.302 Td /F1 9.8 Tf [(1988)] TJ ET 0.267 0.267 0.267 rg 177.927 585.972 80.585 0.750 re f 177.927 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 574.302 Td /F1 9.8 Tf [(USA)] TJ ET 0.267 0.267 0.267 rg 257.761 585.972 47.042 0.750 re f 257.761 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 574.302 Td /F1 9.8 Tf [(611)] TJ ET 0.267 0.267 0.267 rg 304.053 585.972 57.366 0.750 re f 304.053 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 574.302 Td /F1 9.8 Tf [(5)] TJ ET 0.267 0.267 0.267 rg 360.669 585.972 32.064 0.750 re f 360.669 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 574.302 Td /F1 9.8 Tf [(0.8)] TJ ET 0.267 0.267 0.267 rg 391.983 585.972 57.366 0.750 re f 391.983 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 574.302 Td /F1 9.8 Tf [(25)] TJ ET 0.267 0.267 0.267 rg 448.598 585.972 38.912 0.750 re f 448.598 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 574.302 Td /F1 9.8 Tf [(4.1)] TJ ET 0.267 0.267 0.267 rg 486.760 585.972 55.953 0.750 re f 486.760 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 574.302 Td /F1 9.8 Tf [(30)] TJ ET 0.267 0.267 0.267 rg 541.963 585.972 38.912 0.750 re f 541.963 554.094 0.750 32.628 re f 580.125 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 574.302 Td /F1 9.8 Tf [(4.9)] TJ ET 0.267 0.267 0.267 rg 26.625 554.094 81.984 0.750 re f 26.625 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 542.424 Td /F1 9.8 Tf [(Fromtali et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 530.044 Td /F4 8.7 Tf [(46)] TJ ET 0.271 0.267 0.267 rg BT 43.939 529.462 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 554.094 70.818 0.750 re f 107.859 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 542.424 Td /F1 9.8 Tf [(1990)] TJ ET 0.267 0.267 0.267 rg 177.927 554.094 80.585 0.750 re f 177.927 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 542.424 Td /F1 9.8 Tf [(Italy)] TJ ET 0.267 0.267 0.267 rg 257.761 554.094 47.042 0.750 re f 257.761 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 542.424 Td /F1 9.8 Tf [(299)] TJ ET 0.267 0.267 0.267 rg 304.053 554.094 57.366 0.750 re f 304.053 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 542.424 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 360.669 554.094 32.064 0.750 re f 360.669 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 542.424 Td /F1 9.8 Tf [(0.7)] TJ ET 0.267 0.267 0.267 rg 391.983 554.094 57.366 0.750 re f 391.983 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 542.424 Td /F1 9.8 Tf [(9)] TJ ET 0.267 0.267 0.267 rg 448.598 554.094 38.912 0.750 re f 448.598 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 542.424 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 486.760 554.094 55.953 0.750 re f 486.760 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 542.424 Td /F1 9.8 Tf [(11)] TJ ET 0.267 0.267 0.267 rg 541.963 554.094 38.912 0.750 re f 541.963 522.216 0.750 32.628 re f 580.125 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 542.424 Td /F1 9.8 Tf [(3.7)] TJ ET 0.267 0.267 0.267 rg 26.625 522.216 81.984 0.750 re f 26.625 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 510.546 Td /F1 9.8 Tf [(Pavomi et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 498.166 Td /F4 8.7 Tf [(47)] TJ ET 0.271 0.267 0.267 rg BT 43.939 497.584 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 522.216 70.818 0.750 re f 107.859 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 510.546 Td /F1 9.8 Tf [(1990)] TJ ET 0.267 0.267 0.267 rg 177.927 522.216 80.585 0.750 re f 177.927 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 510.546 Td /F1 9.8 Tf [(Italy)] TJ ET 0.267 0.267 0.267 rg 257.761 522.216 47.042 0.750 re f 257.761 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 510.546 Td /F1 9.8 Tf [(47)] TJ ET 0.267 0.267 0.267 rg 304.053 522.216 57.366 0.750 re f 304.053 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 510.546 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 522.216 32.064 0.750 re f 360.669 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 510.546 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 522.216 57.366 0.750 re f 391.983 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 510.546 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 448.598 522.216 38.912 0.750 re f 448.598 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 510.546 Td /F1 9.8 Tf [(3.1)] TJ ET 0.267 0.267 0.267 rg 486.760 522.216 55.953 0.750 re f 486.760 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 510.546 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 541.963 522.216 38.912 0.750 re f 541.963 490.338 0.750 32.628 re f 580.125 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 510.546 Td /F1 9.8 Tf [(2.1)] TJ ET 0.267 0.267 0.267 rg 26.625 490.338 81.984 0.750 re f 26.625 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 475.606 Td /F1 9.8 Tf [(Pridmore)] TJ ET 0.267 0.267 0.267 rg BT 79.231 476.188 Td /F4 8.7 Tf [(48)] TJ ET 0.271 0.267 0.267 rg BT 91.295 475.606 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 490.338 70.818 0.750 re f 107.859 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 478.668 Td /F1 9.8 Tf [(1990)] TJ ET 0.267 0.267 0.267 rg 177.927 490.338 80.585 0.750 re f 177.927 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 478.668 Td /F1 9.8 Tf [(Tasmania)] TJ ET 0.267 0.267 0.267 rg 257.761 490.338 47.042 0.750 re f 257.761 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 478.668 Td /F1 9.8 Tf [(48)] TJ ET 0.267 0.267 0.267 rg 304.053 490.338 57.366 0.750 re f 304.053 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 478.668 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 490.338 32.064 0.750 re f 360.669 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 478.668 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 490.338 57.366 0.750 re f 391.983 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 478.668 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 448.598 490.338 38.912 0.750 re f 448.598 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 478.668 Td /F1 9.8 Tf [(6.3)] TJ ET 0.267 0.267 0.267 rg 486.760 490.338 55.953 0.750 re f 486.760 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 478.668 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 541.963 490.338 38.912 0.750 re f 541.963 468.360 0.750 22.728 re f 580.125 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 478.668 Td /F1 9.8 Tf [(6.3)] TJ ET 0.267 0.267 0.267 rg 26.625 468.360 81.984 0.750 re f 26.625 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 453.628 Td /F1 9.8 Tf [(Roos et al)] TJ ET 0.267 0.267 0.267 rg BT 83.472 454.210 Td /F4 8.7 Tf [(49)] TJ ET 0.271 0.267 0.267 rg BT 95.536 453.628 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 468.360 70.818 0.750 re f 107.859 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 456.690 Td /F1 9.8 Tf [(1991)] TJ ET 0.267 0.267 0.267 rg 177.927 468.360 80.585 0.750 re f 177.927 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 456.690 Td /F1 9.8 Tf [(Netherlands)] TJ ET 0.267 0.267 0.267 rg 257.761 468.360 47.042 0.750 re f 257.761 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 456.690 Td /F1 9.8 Tf [(632)] TJ ET 0.267 0.267 0.267 rg 304.053 468.360 57.366 0.750 re f 304.053 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 456.690 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 468.360 32.064 0.750 re f 360.669 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 456.690 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 468.360 57.366 0.750 re f 391.983 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 456.690 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 468.360 38.912 0.750 re f 448.598 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 456.690 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 468.360 55.953 0.750 re f 486.760 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 456.690 Td /F1 9.8 Tf [(12)] TJ ET 0.267 0.267 0.267 rg 541.963 468.360 38.912 0.750 re f 541.963 446.382 0.750 22.728 re f 580.125 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 456.690 Td /F1 9.8 Tf [(1.9)] TJ ET 0.267 0.267 0.267 rg 26.625 446.382 81.984 0.750 re f 26.625 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 31.875 431.650 Td /F1 9.8 Tf [(Leung et al)] TJ ET 0.267 0.267 0.267 rg BT 86.563 432.232 Td /F4 8.7 Tf [(50)] TJ ET 0.271 0.267 0.267 rg BT 98.627 431.650 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 446.382 70.818 0.750 re f 107.859 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 113.109 434.712 Td /F1 9.8 Tf [(1992)] TJ ET 0.267 0.267 0.267 rg 177.927 446.382 80.585 0.750 re f 177.927 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 183.177 434.712 Td /F1 9.8 Tf [(China &)] TJ ET BT 183.177 424.812 Td /F1 9.8 Tf [(Hong Kong)] TJ ET 0.267 0.267 0.267 rg 257.761 446.382 47.042 0.750 re f 257.761 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 263.011 434.712 Td /F1 9.8 Tf [(89)] TJ ET 0.267 0.267 0.267 rg 304.053 446.382 57.366 0.750 re f 304.053 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 309.303 434.712 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 360.669 446.382 32.064 0.750 re f 360.669 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 365.919 434.712 Td /F1 9.8 Tf [(4.5)] TJ ET 0.267 0.267 0.267 rg 391.983 446.382 57.366 0.750 re f 391.983 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 397.233 434.712 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 448.598 446.382 38.912 0.750 re f 448.598 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 453.848 434.712 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 486.760 446.382 55.953 0.750 re f 486.760 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 492.010 434.712 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 541.963 446.382 38.912 0.750 re f 541.963 418.332 0.750 28.800 re f 580.125 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 547.213 434.712 Td /F1 9.8 Tf [(4.5)] TJ ET 0.267 0.267 0.267 rg 26.625 418.332 81.984 0.750 re f 26.625 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 403.600 Td /F1 9.8 Tf [(Ridley et al)] TJ ET 0.267 0.267 0.267 rg BT 89.839 404.182 Td /F4 8.7 Tf [(51)] TJ ET 0.271 0.267 0.267 rg BT 31.875 392.934 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 418.332 70.818 0.750 re f 107.859 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 406.662 Td /F1 9.8 Tf [(1992)] TJ ET 0.267 0.267 0.267 rg 177.927 418.332 80.585 0.750 re f 177.927 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 406.662 Td /F1 9.8 Tf [(USA)] TJ ET 0.267 0.267 0.267 rg 257.761 418.332 47.042 0.750 re f 257.761 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 406.662 Td /F1 9.8 Tf [(3945)] TJ ET 0.267 0.267 0.267 rg 304.053 418.332 57.366 0.750 re f 304.053 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 406.662 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 418.332 32.064 0.750 re f 360.669 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 406.662 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 418.332 57.366 0.750 re f 391.983 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 406.662 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 418.332 38.912 0.750 re f 448.598 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 406.662 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 418.332 55.953 0.750 re f 486.760 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 406.662 Td /F1 9.8 Tf [(208)] TJ ET 0.267 0.267 0.267 rg 541.963 418.332 38.912 0.750 re f 541.963 386.454 0.750 32.628 re f 580.125 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 406.662 Td /F1 9.8 Tf [(5.3)] TJ ET 0.267 0.267 0.267 rg 26.625 386.454 81.984 0.750 re f 26.625 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 374.784 Td /F1 9.8 Tf [(Morrison &)] TJ ET BT 31.875 361.822 Td /F1 9.8 Tf [(Nevin)] TJ ET 0.267 0.267 0.267 rg BT 59.828 362.404 Td /F4 8.7 Tf [(52)] TJ ET 0.271 0.267 0.267 rg BT 71.892 361.822 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 386.454 70.818 0.750 re f 107.859 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 374.784 Td /F1 9.8 Tf [(1993)] TJ ET 0.267 0.267 0.267 rg 177.927 386.454 80.585 0.750 re f 177.927 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 374.784 Td /F1 9.8 Tf [(N Ireland)] TJ ET 0.267 0.267 0.267 rg 257.761 386.454 47.042 0.750 re f 257.761 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 374.784 Td /F1 9.8 Tf [(12)] TJ ET 0.267 0.267 0.267 rg 304.053 386.454 57.366 0.750 re f 304.053 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 374.784 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 386.454 32.064 0.750 re f 360.669 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 374.784 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 386.454 57.366 0.750 re f 391.983 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 374.784 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 448.598 386.454 38.912 0.750 re f 448.598 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 374.784 Td /F1 9.8 Tf [(8.3)] TJ ET 0.267 0.267 0.267 rg 486.760 386.454 55.953 0.750 re f 486.760 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 374.784 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 541.963 386.454 38.912 0.750 re f 541.963 354.576 0.750 32.628 re f 580.125 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 374.784 Td /F1 9.8 Tf [(8.3)] TJ ET 0.267 0.267 0.267 rg 26.625 354.576 81.984 0.750 re f 26.625 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 339.844 Td /F1 9.8 Tf [(Roos et al)] TJ ET 0.267 0.267 0.267 rg BT 83.472 340.426 Td /F4 8.7 Tf [(53)] TJ ET 0.271 0.267 0.267 rg BT 95.536 339.844 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 354.576 70.818 0.750 re f 107.859 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 342.906 Td /F1 9.8 Tf [(1993)] TJ ET 0.267 0.267 0.267 rg 177.927 354.576 80.585 0.750 re f 177.927 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 342.906 Td /F1 9.8 Tf [(Netherlands)] TJ ET 0.267 0.267 0.267 rg 257.761 354.576 47.042 0.750 re f 257.761 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 342.906 Td /F1 9.8 Tf [(1106)] TJ ET 0.267 0.267 0.267 rg 304.053 354.576 57.366 0.750 re f 304.053 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 342.906 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 354.576 32.064 0.750 re f 360.669 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 342.906 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 354.576 57.366 0.750 re f 391.983 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 342.906 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 354.576 38.912 0.750 re f 448.598 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 342.906 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 354.576 55.953 0.750 re f 486.760 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 342.906 Td /F1 9.8 Tf [(6.5)] TJ ET 0.267 0.267 0.267 rg 541.963 354.576 38.912 0.750 re f 541.963 332.598 0.750 22.728 re f 580.125 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 342.906 Td /F1 9.8 Tf [(5.9)] TJ ET 0.267 0.267 0.267 rg 26.625 332.598 81.984 0.750 re f 26.625 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 320.928 Td /F1 9.8 Tf [(Simpson et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 308.548 Td /F4 8.7 Tf [(54)] TJ ET 0.271 0.267 0.267 rg BT 43.939 307.966 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 332.598 70.818 0.750 re f 107.859 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 320.928 Td /F1 9.8 Tf [(1993)] TJ ET 0.267 0.267 0.267 rg 177.927 332.598 80.585 0.750 re f 177.927 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 320.928 Td /F1 9.8 Tf [(Scotland)] TJ ET 0.267 0.267 0.267 rg 257.761 332.598 47.042 0.750 re f 257.761 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 320.928 Td /F1 9.8 Tf [(82)] TJ ET 0.267 0.267 0.267 rg 304.053 332.598 57.366 0.750 re f 304.053 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 320.928 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 332.598 32.064 0.750 re f 360.669 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 320.928 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 332.598 57.366 0.750 re f 391.983 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 320.928 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 448.598 332.598 38.912 0.750 re f 448.598 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 320.928 Td /F1 9.8 Tf [(3.7)] TJ ET 0.267 0.267 0.267 rg 486.760 332.598 55.953 0.750 re f 486.760 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 320.928 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 541.963 332.598 38.912 0.750 re f 541.963 300.720 0.750 32.628 re f 580.125 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 320.928 Td /F1 9.8 Tf [(3.7)] TJ ET 0.267 0.267 0.267 rg 26.625 300.720 81.984 0.750 re f 26.625 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 289.050 Td /F1 9.8 Tf [(Watt & Seller)] TJ ET 0.267 0.267 0.267 rg BT 31.875 276.670 Td /F4 8.7 Tf [(55)] TJ ET 0.271 0.267 0.267 rg BT 43.939 276.088 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 300.720 70.818 0.750 re f 107.859 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 289.050 Td /F1 9.8 Tf [(1993)] TJ ET 0.267 0.267 0.267 rg 177.927 300.720 80.585 0.750 re f 177.927 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 289.050 Td /F1 9.8 Tf [(England)] TJ ET 0.267 0.267 0.267 rg 257.761 300.720 47.042 0.750 re f 257.761 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 289.050 Td /F1 9.8 Tf [(101)] TJ ET 0.267 0.267 0.267 rg 304.053 300.720 57.366 0.750 re f 304.053 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 289.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 300.720 32.064 0.750 re f 360.669 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 289.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 300.720 57.366 0.750 re f 391.983 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 289.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 300.720 38.912 0.750 re f 448.598 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 289.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 300.720 55.953 0.750 re f 486.760 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 289.050 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 541.963 300.720 38.912 0.750 re f 541.963 268.842 0.750 32.628 re f 580.125 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 289.050 Td /F1 9.8 Tf [(4.0)] TJ ET 0.267 0.267 0.267 rg 26.625 268.842 81.984 0.750 re f 26.625 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 254.110 Td /F1 9.8 Tf [(Shiwach)] TJ ET 0.267 0.267 0.267 rg BT 75.555 254.692 Td /F4 8.7 Tf [(56)] TJ ET 0.271 0.267 0.267 rg BT 87.619 254.110 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 268.842 70.818 0.750 re f 107.859 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 257.172 Td /F1 9.8 Tf [(1994)] TJ ET 0.267 0.267 0.267 rg 177.927 268.842 80.585 0.750 re f 177.927 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 257.172 Td /F1 9.8 Tf [(England)] TJ ET 0.267 0.267 0.267 rg 257.761 268.842 47.042 0.750 re f 257.761 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 257.172 Td /F1 9.8 Tf [(135)] TJ ET 0.267 0.267 0.267 rg 304.053 268.842 57.366 0.750 re f 304.053 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 257.172 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 268.842 32.064 0.750 re f 360.669 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 257.172 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 268.842 57.366 0.750 re f 391.983 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 257.172 Td /F1 9.8 Tf [(8)] TJ ET 0.267 0.267 0.267 rg 448.598 268.842 38.912 0.750 re f 448.598 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 257.172 Td /F1 9.8 Tf [(5.9)] TJ ET 0.267 0.267 0.267 rg 486.760 268.842 55.953 0.750 re f 486.760 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 257.172 Td /F1 9.8 Tf [(8)] TJ ET 0.267 0.267 0.267 rg 541.963 268.842 38.912 0.750 re f 541.963 246.864 0.750 22.728 re f 580.125 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 257.172 Td /F1 9.8 Tf [(5.9)] TJ ET 0.267 0.267 0.267 rg 26.625 246.864 81.984 0.750 re f 26.625 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 235.194 Td /F1 9.8 Tf [(Morrison et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 222.814 Td /F4 8.7 Tf [(57)] TJ ET 0.271 0.267 0.267 rg BT 43.939 222.232 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 246.864 70.818 0.750 re f 107.859 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 235.194 Td /F1 9.8 Tf [(1995)] TJ ET 0.267 0.267 0.267 rg 177.927 246.864 80.585 0.750 re f 177.927 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 235.194 Td /F1 9.8 Tf [(N Ireland)] TJ ET 0.267 0.267 0.267 rg 257.761 246.864 47.042 0.750 re f 257.761 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 235.194 Td /F1 9.8 Tf [(101)] TJ ET 0.267 0.267 0.267 rg 304.053 246.864 57.366 0.750 re f 304.053 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 235.194 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 360.669 246.864 32.064 0.750 re f 360.669 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 235.194 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 391.983 246.864 57.366 0.750 re f 391.983 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 235.194 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 448.598 246.864 38.912 0.750 re f 448.598 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 235.194 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 486.760 246.864 55.953 0.750 re f 486.760 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 235.194 Td /F1 9.8 Tf [(6)] TJ ET 0.267 0.267 0.267 rg 541.963 246.864 38.912 0.750 re f 541.963 214.986 0.750 32.628 re f 580.125 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 235.194 Td /F1 9.8 Tf [(6)] TJ ET 0.267 0.267 0.267 rg 26.625 214.986 81.984 0.750 re f 26.625 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 203.316 Td /F1 9.8 Tf [(Sanchest et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 190.936 Td /F4 8.7 Tf [(59)] TJ ET 0.271 0.267 0.267 rg BT 43.939 190.354 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 214.986 70.818 0.750 re f 107.859 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 203.316 Td /F1 9.8 Tf [(1996)] TJ ET 0.267 0.267 0.267 rg 177.927 214.986 80.585 0.750 re f 177.927 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 203.316 Td /F1 9.8 Tf [(Spain)] TJ ET 0.267 0.267 0.267 rg 257.761 214.986 47.042 0.750 re f 257.761 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 203.316 Td /F1 9.8 Tf [(31)] TJ ET 0.267 0.267 0.267 rg 304.053 214.986 57.366 0.750 re f 304.053 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 203.316 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 214.986 32.064 0.750 re f 360.669 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 203.316 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 214.986 57.366 0.750 re f 391.983 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 203.316 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 448.598 214.986 38.912 0.750 re f 448.598 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 203.316 Td /F1 9.8 Tf [(12.9)] TJ ET 0.267 0.267 0.267 rg 486.760 214.986 55.953 0.750 re f 486.760 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 203.316 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 541.963 214.986 38.912 0.750 re f 541.963 183.108 0.750 32.628 re f 580.125 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 203.316 Td /F1 9.8 Tf [(12.9)] TJ ET 0.267 0.267 0.267 rg 26.625 183.108 81.984 0.750 re f 26.625 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 171.438 Td /F1 9.8 Tf [(Alonso et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 159.058 Td /F4 8.7 Tf [(58)] TJ ET 0.271 0.267 0.267 rg BT 43.939 158.476 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 183.108 70.818 0.750 re f 107.859 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 171.438 Td /F1 9.8 Tf [(1997)] TJ ET 0.267 0.267 0.267 rg 177.927 183.108 80.585 0.750 re f 177.927 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 171.438 Td /F1 9.8 Tf [(Mexico)] TJ ET 0.267 0.267 0.267 rg 257.761 183.108 47.042 0.750 re f 257.761 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 171.438 Td /F1 9.8 Tf [(83)] TJ ET 0.267 0.267 0.267 rg 304.053 183.108 57.366 0.750 re f 304.053 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 171.438 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 183.108 32.064 0.750 re f 360.669 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 171.438 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 183.108 57.366 0.750 re f 391.983 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 171.438 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 183.108 38.912 0.750 re f 448.598 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 171.438 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 183.108 55.953 0.750 re f 486.760 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 171.438 Td /F1 9.8 Tf [(6)] TJ ET 0.267 0.267 0.267 rg 541.963 183.108 38.912 0.750 re f 541.963 151.230 0.750 32.628 re f 580.125 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 171.438 Td /F1 9.8 Tf [(7.2)] TJ ET 0.267 0.267 0.267 rg 26.625 151.230 81.984 0.750 re f 26.625 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 139.560 Td /F1 9.8 Tf [(Siesling et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 127.180 Td /F4 8.7 Tf [(4)] TJ ET 0.271 0.267 0.267 rg BT 37.907 126.598 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 151.230 70.818 0.750 re f 107.859 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 139.560 Td /F1 9.8 Tf [(1997)] TJ ET 0.267 0.267 0.267 rg 177.927 151.230 80.585 0.750 re f 177.927 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 139.560 Td /F1 9.8 Tf [(Netherlands)] TJ ET 0.267 0.267 0.267 rg 257.761 151.230 47.042 0.750 re f 257.761 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 139.560 Td /F1 9.8 Tf [(2787)] TJ ET 0.267 0.267 0.267 rg 304.053 151.230 57.366 0.750 re f 304.053 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 139.560 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 151.230 32.064 0.750 re f 360.669 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 139.560 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 151.230 57.366 0.750 re f 391.983 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 139.560 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 151.230 38.912 0.750 re f 448.598 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 139.560 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 151.230 55.953 0.750 re f 486.760 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 139.560 Td /F1 9.8 Tf [(65)] TJ ET 0.267 0.267 0.267 rg 541.963 151.230 38.912 0.750 re f 541.963 119.352 0.750 32.628 re f 580.125 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 139.560 Td /F1 9.8 Tf [(2.3)] TJ ET 0.267 0.267 0.267 rg 26.625 119.352 81.984 0.750 re f 26.625 77.574 81.984 0.750 re f 26.625 77.574 0.750 42.528 re f 0.271 0.267 0.267 rg BT 31.875 107.682 Td /F1 9.8 Tf [(Gomez-)] TJ ET BT 31.875 94.720 Td /F1 9.8 Tf [(Totosa et al)] TJ ET 0.267 0.267 0.267 rg BT 89.351 95.302 Td /F4 8.7 Tf [(59)] TJ ET 0.271 0.267 0.267 rg BT 31.875 84.054 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 119.352 70.818 0.750 re f 107.859 77.574 70.818 0.750 re f 107.859 77.574 0.750 42.528 re f 0.271 0.267 0.267 rg BT 113.109 107.682 Td /F1 9.8 Tf [(1998)] TJ ET 0.267 0.267 0.267 rg 177.927 119.352 80.585 0.750 re f 177.927 77.574 80.585 0.750 re f 177.927 77.574 0.750 42.528 re f 0.271 0.267 0.267 rg BT 183.177 107.682 Td /F1 9.8 Tf [(Spain)] TJ ET 0.267 0.267 0.267 rg 257.761 119.352 47.042 0.750 re f 257.761 77.574 47.042 0.750 re f 257.761 77.574 0.750 42.528 re f 0.271 0.267 0.267 rg BT 263.011 107.682 Td /F1 9.8 Tf [(81)] TJ ET 0.267 0.267 0.267 rg 304.053 119.352 57.366 0.750 re f 304.053 77.574 57.366 0.750 re f 304.053 77.574 0.750 42.528 re f 0.271 0.267 0.267 rg BT 309.303 107.682 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 360.669 119.352 32.064 0.750 re f 360.669 77.574 32.064 0.750 re f 360.669 77.574 0.750 42.528 re f 0.271 0.267 0.267 rg BT 365.919 107.682 Td /F1 9.8 Tf [(1.2)] TJ ET 0.267 0.267 0.267 rg 391.983 119.352 57.366 0.750 re f 391.983 77.574 57.366 0.750 re f 391.983 77.574 0.750 42.528 re f 0.271 0.267 0.267 rg BT 397.233 107.682 Td /F1 9.8 Tf [(6)] TJ ET 0.267 0.267 0.267 rg 448.598 119.352 38.912 0.750 re f 448.598 77.574 38.912 0.750 re f 448.598 77.574 0.750 42.528 re f 0.271 0.267 0.267 rg BT 453.848 107.682 Td /F1 9.8 Tf [(7.4)] TJ ET 0.267 0.267 0.267 rg 486.760 119.352 55.953 0.750 re f 486.760 77.574 55.953 0.750 re f 486.760 77.574 0.750 42.528 re f 0.271 0.267 0.267 rg BT 492.010 107.682 Td /F1 9.8 Tf [(7)] TJ ET 0.267 0.267 0.267 rg 541.963 119.352 38.912 0.750 re f 541.963 77.574 38.912 0.750 re f 541.963 77.574 0.750 42.528 re f 580.125 77.574 0.750 42.528 re f 0.271 0.267 0.267 rg BT 547.213 107.682 Td /F1 9.8 Tf [(8.6)] TJ ET Q q 15.000 77.199 577.500 699.801 re W n 1.000 1.000 1.000 rg 26.250 77.199 555.000 699.801 re f 0.965 0.965 0.965 rg 27.000 745.737 81.234 31.263 re f 0.267 0.267 0.267 rg 26.625 745.362 0.750 31.638 re f 0.271 0.267 0.267 rg BT 31.500 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 108.234 745.737 70.068 31.263 re f 0.271 0.267 0.267 rg BT 112.734 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 178.302 745.737 79.835 31.263 re f 0.271 0.267 0.267 rg BT 182.802 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 258.136 745.737 46.292 31.263 re f 0.271 0.267 0.267 rg BT 262.636 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 304.428 745.737 56.616 31.263 re f 0.271 0.267 0.267 rg BT 308.928 764.645 Td /F4 9.8 Tf [(0 -10 )] TJ ET BT 308.928 749.201 Td /F4 9.8 Tf [(years)] TJ ET 0.965 0.965 0.965 rg 361.044 745.737 31.314 31.263 re f 0.271 0.267 0.267 rg BT 365.544 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 392.358 745.737 56.616 31.263 re f 0.271 0.267 0.267 rg BT 396.858 764.645 Td /F4 9.8 Tf [(11-20 )] TJ ET BT 396.858 749.201 Td /F4 9.8 Tf [(years)] TJ ET 0.965 0.965 0.965 rg 448.973 745.737 38.162 31.263 re f 0.271 0.267 0.267 rg BT 453.473 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 487.135 745.737 55.203 31.263 re f 0.271 0.267 0.267 rg BT 491.635 764.645 Td /F4 9.8 Tf [(Total )] TJ ET BT 491.635 749.201 Td /F4 9.8 Tf [(JHD)] TJ ET 0.965 0.965 0.965 rg 542.338 745.737 38.162 31.263 re f 0.267 0.267 0.267 rg 580.125 745.362 0.750 31.638 re f 0.271 0.267 0.267 rg BT 546.838 764.645 Td /F4 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 26.625 745.362 81.984 0.750 re f 26.625 713.484 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 733.692 Td /F1 9.8 Tf [(Farrer &)] TJ ET BT 31.875 720.730 Td /F1 9.8 Tf [(Conneally)] TJ ET 0.267 0.267 0.267 rg BT 80.177 721.312 Td /F4 8.7 Tf [(41)] TJ ET 0.271 0.267 0.267 rg BT 92.241 720.730 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 745.362 70.818 0.750 re f 107.859 713.484 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 733.692 Td /F1 9.8 Tf [(1985)] TJ ET 0.267 0.267 0.267 rg 177.927 745.362 80.585 0.750 re f 177.927 713.484 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 733.692 Td /F1 9.8 Tf [(USA)] TJ ET 0.267 0.267 0.267 rg 257.761 745.362 47.042 0.750 re f 257.761 713.484 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 733.692 Td /F1 9.8 Tf [(569)] TJ ET 0.267 0.267 0.267 rg 304.053 745.362 57.366 0.750 re f 304.053 713.484 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 733.692 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 360.669 745.362 32.064 0.750 re f 360.669 713.484 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 733.692 Td /F1 9.8 Tf [(0.7)] TJ ET 0.267 0.267 0.267 rg 391.983 745.362 57.366 0.750 re f 391.983 713.484 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 733.692 Td /F1 9.8 Tf [(24)] TJ ET 0.267 0.267 0.267 rg 448.598 745.362 38.912 0.750 re f 448.598 713.484 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 733.692 Td /F1 9.8 Tf [(4.2)] TJ ET 0.267 0.267 0.267 rg 486.760 745.362 55.953 0.750 re f 486.760 713.484 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 733.692 Td /F1 9.8 Tf [(28)] TJ ET 0.267 0.267 0.267 rg 541.963 745.362 38.912 0.750 re f 541.963 713.484 0.750 32.628 re f 580.125 713.484 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 733.692 Td /F1 9.8 Tf [(4.9)] TJ ET 0.267 0.267 0.267 rg 26.625 713.484 81.984 0.750 re f 26.625 681.606 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 701.814 Td /F1 9.8 Tf [(Hayden et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 689.434 Td /F4 8.7 Tf [(42)] TJ ET 0.271 0.267 0.267 rg BT 43.939 688.852 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 713.484 70.818 0.750 re f 107.859 681.606 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 701.814 Td /F1 9.8 Tf [(1985)] TJ ET 0.267 0.267 0.267 rg 177.927 713.484 80.585 0.750 re f 177.927 681.606 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 701.814 Td /F1 9.8 Tf [(USA)] TJ ET 0.267 0.267 0.267 rg 257.761 713.484 47.042 0.750 re f 257.761 681.606 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 701.814 Td /F1 9.8 Tf [(598)] TJ ET 0.267 0.267 0.267 rg 304.053 713.484 57.366 0.750 re f 304.053 681.606 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 701.814 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 713.484 32.064 0.750 re f 360.669 681.606 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 701.814 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 713.484 57.366 0.750 re f 391.983 681.606 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 701.814 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 713.484 38.912 0.750 re f 448.598 681.606 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 701.814 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 713.484 55.953 0.750 re f 486.760 681.606 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 701.814 Td /F1 9.8 Tf [(89)] TJ ET 0.267 0.267 0.267 rg 541.963 713.484 38.912 0.750 re f 541.963 681.606 0.750 32.628 re f 580.125 681.606 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 701.814 Td /F1 9.8 Tf [(14.9)] TJ ET 0.267 0.267 0.267 rg 26.625 681.606 81.984 0.750 re f 26.625 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 669.936 Td /F1 9.8 Tf [(Groppi et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 657.556 Td /F4 8.7 Tf [(43)] TJ ET 0.271 0.267 0.267 rg BT 43.939 656.974 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 681.606 70.818 0.750 re f 107.859 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 669.936 Td /F1 9.8 Tf [(1986)] TJ ET 0.267 0.267 0.267 rg 177.927 681.606 80.585 0.750 re f 177.927 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 669.936 Td /F1 9.8 Tf [(Italy)] TJ ET 0.267 0.267 0.267 rg 257.761 681.606 47.042 0.750 re f 257.761 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 669.936 Td /F1 9.8 Tf [(48)] TJ ET 0.267 0.267 0.267 rg 304.053 681.606 57.366 0.750 re f 304.053 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 669.936 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 681.606 32.064 0.750 re f 360.669 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 669.936 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 681.606 57.366 0.750 re f 391.983 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 669.936 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 681.606 38.912 0.750 re f 448.598 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 669.936 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 681.606 55.953 0.750 re f 486.760 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 669.936 Td /F1 9.8 Tf [(5)] TJ ET 0.267 0.267 0.267 rg 541.963 681.606 38.912 0.750 re f 541.963 649.728 0.750 32.628 re f 580.125 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 669.936 Td /F1 9.8 Tf [(10.4)] TJ ET 0.267 0.267 0.267 rg 26.625 649.728 81.984 0.750 re f 26.625 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 634.996 Td /F1 9.8 Tf [(Young et al)] TJ ET 0.267 0.267 0.267 rg BT 90.160 635.578 Td /F4 8.7 Tf [(44)] TJ ET 0.271 0.267 0.267 rg BT 31.875 624.330 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 649.728 70.818 0.750 re f 107.859 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 638.058 Td /F1 9.8 Tf [(1986)] TJ ET 0.267 0.267 0.267 rg 177.927 649.728 80.585 0.750 re f 177.927 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 638.058 Td /F1 9.8 Tf [(Venezueala)] TJ ET 0.267 0.267 0.267 rg 257.761 649.728 47.042 0.750 re f 257.761 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 638.058 Td /F1 9.8 Tf [(65)] TJ ET 0.267 0.267 0.267 rg 304.053 649.728 57.366 0.750 re f 304.053 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 638.058 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 360.669 649.728 32.064 0.750 re f 360.669 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 638.058 Td /F1 9.8 Tf [(1.5)] TJ ET 0.267 0.267 0.267 rg 391.983 649.728 57.366 0.750 re f 391.983 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 638.058 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 448.598 649.728 38.912 0.750 re f 448.598 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 638.058 Td /F1 9.8 Tf [(4.6)] TJ ET 0.267 0.267 0.267 rg 486.760 649.728 55.953 0.750 re f 486.760 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 638.058 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 541.963 649.728 38.912 0.750 re f 541.963 617.850 0.750 32.628 re f 580.125 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 638.058 Td /F1 9.8 Tf [(6.2)] TJ ET 0.267 0.267 0.267 rg 26.625 617.850 81.984 0.750 re f 26.625 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 606.180 Td /F1 9.8 Tf [(Folstein et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 593.800 Td /F4 8.7 Tf [(19)] TJ ET 0.271 0.267 0.267 rg BT 43.939 593.218 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 617.850 70.818 0.750 re f 107.859 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 606.180 Td /F1 9.8 Tf [(1987)] TJ ET 0.267 0.267 0.267 rg 177.927 617.850 80.585 0.750 re f 177.927 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 606.180 Td /F1 9.8 Tf [(USA)] TJ ET 0.267 0.267 0.267 rg 257.761 617.850 47.042 0.750 re f 257.761 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 606.180 Td /F1 9.8 Tf [(217)] TJ ET 0.267 0.267 0.267 rg 304.053 617.850 57.366 0.750 re f 304.053 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 606.180 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 617.850 32.064 0.750 re f 360.669 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 606.180 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 617.850 57.366 0.750 re f 391.983 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 606.180 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 617.850 38.912 0.750 re f 448.598 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 606.180 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 617.850 55.953 0.750 re f 486.760 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 606.180 Td /F1 9.8 Tf [(15)] TJ ET 0.267 0.267 0.267 rg 541.963 617.850 38.912 0.750 re f 541.963 585.972 0.750 32.628 re f 580.125 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 606.180 Td /F1 9.8 Tf [(6.9)] TJ ET 0.267 0.267 0.267 rg 26.625 585.972 81.984 0.750 re f 26.625 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 574.302 Td /F1 9.8 Tf [(Adams et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 561.922 Td /F4 8.7 Tf [(45)] TJ ET 0.271 0.267 0.267 rg BT 43.939 561.340 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 585.972 70.818 0.750 re f 107.859 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 574.302 Td /F1 9.8 Tf [(1988)] TJ ET 0.267 0.267 0.267 rg 177.927 585.972 80.585 0.750 re f 177.927 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 574.302 Td /F1 9.8 Tf [(USA)] TJ ET 0.267 0.267 0.267 rg 257.761 585.972 47.042 0.750 re f 257.761 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 574.302 Td /F1 9.8 Tf [(611)] TJ ET 0.267 0.267 0.267 rg 304.053 585.972 57.366 0.750 re f 304.053 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 574.302 Td /F1 9.8 Tf [(5)] TJ ET 0.267 0.267 0.267 rg 360.669 585.972 32.064 0.750 re f 360.669 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 574.302 Td /F1 9.8 Tf [(0.8)] TJ ET 0.267 0.267 0.267 rg 391.983 585.972 57.366 0.750 re f 391.983 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 574.302 Td /F1 9.8 Tf [(25)] TJ ET 0.267 0.267 0.267 rg 448.598 585.972 38.912 0.750 re f 448.598 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 574.302 Td /F1 9.8 Tf [(4.1)] TJ ET 0.267 0.267 0.267 rg 486.760 585.972 55.953 0.750 re f 486.760 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 574.302 Td /F1 9.8 Tf [(30)] TJ ET 0.267 0.267 0.267 rg 541.963 585.972 38.912 0.750 re f 541.963 554.094 0.750 32.628 re f 580.125 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 574.302 Td /F1 9.8 Tf [(4.9)] TJ ET 0.267 0.267 0.267 rg 26.625 554.094 81.984 0.750 re f 26.625 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 542.424 Td /F1 9.8 Tf [(Fromtali et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 530.044 Td /F4 8.7 Tf [(46)] TJ ET 0.271 0.267 0.267 rg BT 43.939 529.462 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 554.094 70.818 0.750 re f 107.859 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 542.424 Td /F1 9.8 Tf [(1990)] TJ ET 0.267 0.267 0.267 rg 177.927 554.094 80.585 0.750 re f 177.927 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 542.424 Td /F1 9.8 Tf [(Italy)] TJ ET 0.267 0.267 0.267 rg 257.761 554.094 47.042 0.750 re f 257.761 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 542.424 Td /F1 9.8 Tf [(299)] TJ ET 0.267 0.267 0.267 rg 304.053 554.094 57.366 0.750 re f 304.053 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 542.424 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 360.669 554.094 32.064 0.750 re f 360.669 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 542.424 Td /F1 9.8 Tf [(0.7)] TJ ET 0.267 0.267 0.267 rg 391.983 554.094 57.366 0.750 re f 391.983 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 542.424 Td /F1 9.8 Tf [(9)] TJ ET 0.267 0.267 0.267 rg 448.598 554.094 38.912 0.750 re f 448.598 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 542.424 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 486.760 554.094 55.953 0.750 re f 486.760 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 542.424 Td /F1 9.8 Tf [(11)] TJ ET 0.267 0.267 0.267 rg 541.963 554.094 38.912 0.750 re f 541.963 522.216 0.750 32.628 re f 580.125 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 542.424 Td /F1 9.8 Tf [(3.7)] TJ ET 0.267 0.267 0.267 rg 26.625 522.216 81.984 0.750 re f 26.625 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 510.546 Td /F1 9.8 Tf [(Pavomi et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 498.166 Td /F4 8.7 Tf [(47)] TJ ET 0.271 0.267 0.267 rg BT 43.939 497.584 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 522.216 70.818 0.750 re f 107.859 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 510.546 Td /F1 9.8 Tf [(1990)] TJ ET 0.267 0.267 0.267 rg 177.927 522.216 80.585 0.750 re f 177.927 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 510.546 Td /F1 9.8 Tf [(Italy)] TJ ET 0.267 0.267 0.267 rg 257.761 522.216 47.042 0.750 re f 257.761 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 510.546 Td /F1 9.8 Tf [(47)] TJ ET 0.267 0.267 0.267 rg 304.053 522.216 57.366 0.750 re f 304.053 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 510.546 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 522.216 32.064 0.750 re f 360.669 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 510.546 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 522.216 57.366 0.750 re f 391.983 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 510.546 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 448.598 522.216 38.912 0.750 re f 448.598 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 510.546 Td /F1 9.8 Tf [(3.1)] TJ ET 0.267 0.267 0.267 rg 486.760 522.216 55.953 0.750 re f 486.760 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 510.546 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 541.963 522.216 38.912 0.750 re f 541.963 490.338 0.750 32.628 re f 580.125 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 510.546 Td /F1 9.8 Tf [(2.1)] TJ ET 0.267 0.267 0.267 rg 26.625 490.338 81.984 0.750 re f 26.625 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 475.606 Td /F1 9.8 Tf [(Pridmore)] TJ ET 0.267 0.267 0.267 rg BT 79.231 476.188 Td /F4 8.7 Tf [(48)] TJ ET 0.271 0.267 0.267 rg BT 91.295 475.606 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 490.338 70.818 0.750 re f 107.859 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 478.668 Td /F1 9.8 Tf [(1990)] TJ ET 0.267 0.267 0.267 rg 177.927 490.338 80.585 0.750 re f 177.927 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 478.668 Td /F1 9.8 Tf [(Tasmania)] TJ ET 0.267 0.267 0.267 rg 257.761 490.338 47.042 0.750 re f 257.761 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 478.668 Td /F1 9.8 Tf [(48)] TJ ET 0.267 0.267 0.267 rg 304.053 490.338 57.366 0.750 re f 304.053 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 478.668 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 490.338 32.064 0.750 re f 360.669 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 478.668 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 490.338 57.366 0.750 re f 391.983 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 478.668 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 448.598 490.338 38.912 0.750 re f 448.598 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 478.668 Td /F1 9.8 Tf [(6.3)] TJ ET 0.267 0.267 0.267 rg 486.760 490.338 55.953 0.750 re f 486.760 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 478.668 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 541.963 490.338 38.912 0.750 re f 541.963 468.360 0.750 22.728 re f 580.125 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 478.668 Td /F1 9.8 Tf [(6.3)] TJ ET 0.267 0.267 0.267 rg 26.625 468.360 81.984 0.750 re f 26.625 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 453.628 Td /F1 9.8 Tf [(Roos et al)] TJ ET 0.267 0.267 0.267 rg BT 83.472 454.210 Td /F4 8.7 Tf [(49)] TJ ET 0.271 0.267 0.267 rg BT 95.536 453.628 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 468.360 70.818 0.750 re f 107.859 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 456.690 Td /F1 9.8 Tf [(1991)] TJ ET 0.267 0.267 0.267 rg 177.927 468.360 80.585 0.750 re f 177.927 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 456.690 Td /F1 9.8 Tf [(Netherlands)] TJ ET 0.267 0.267 0.267 rg 257.761 468.360 47.042 0.750 re f 257.761 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 456.690 Td /F1 9.8 Tf [(632)] TJ ET 0.267 0.267 0.267 rg 304.053 468.360 57.366 0.750 re f 304.053 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 456.690 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 468.360 32.064 0.750 re f 360.669 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 456.690 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 468.360 57.366 0.750 re f 391.983 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 456.690 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 468.360 38.912 0.750 re f 448.598 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 456.690 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 468.360 55.953 0.750 re f 486.760 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 456.690 Td /F1 9.8 Tf [(12)] TJ ET 0.267 0.267 0.267 rg 541.963 468.360 38.912 0.750 re f 541.963 446.382 0.750 22.728 re f 580.125 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 456.690 Td /F1 9.8 Tf [(1.9)] TJ ET 0.267 0.267 0.267 rg 26.625 446.382 81.984 0.750 re f 26.625 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 31.875 431.650 Td /F1 9.8 Tf [(Leung et al)] TJ ET 0.267 0.267 0.267 rg BT 86.563 432.232 Td /F4 8.7 Tf [(50)] TJ ET 0.271 0.267 0.267 rg BT 98.627 431.650 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 446.382 70.818 0.750 re f 107.859 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 113.109 434.712 Td /F1 9.8 Tf [(1992)] TJ ET 0.267 0.267 0.267 rg 177.927 446.382 80.585 0.750 re f 177.927 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 183.177 434.712 Td /F1 9.8 Tf [(China &)] TJ ET BT 183.177 424.812 Td /F1 9.8 Tf [(Hong Kong)] TJ ET 0.267 0.267 0.267 rg 257.761 446.382 47.042 0.750 re f 257.761 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 263.011 434.712 Td /F1 9.8 Tf [(89)] TJ ET 0.267 0.267 0.267 rg 304.053 446.382 57.366 0.750 re f 304.053 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 309.303 434.712 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 360.669 446.382 32.064 0.750 re f 360.669 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 365.919 434.712 Td /F1 9.8 Tf [(4.5)] TJ ET 0.267 0.267 0.267 rg 391.983 446.382 57.366 0.750 re f 391.983 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 397.233 434.712 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 448.598 446.382 38.912 0.750 re f 448.598 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 453.848 434.712 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 486.760 446.382 55.953 0.750 re f 486.760 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 492.010 434.712 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 541.963 446.382 38.912 0.750 re f 541.963 418.332 0.750 28.800 re f 580.125 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 547.213 434.712 Td /F1 9.8 Tf [(4.5)] TJ ET 0.267 0.267 0.267 rg 26.625 418.332 81.984 0.750 re f 26.625 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 403.600 Td /F1 9.8 Tf [(Ridley et al)] TJ ET 0.267 0.267 0.267 rg BT 89.839 404.182 Td /F4 8.7 Tf [(51)] TJ ET 0.271 0.267 0.267 rg BT 31.875 392.934 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 418.332 70.818 0.750 re f 107.859 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 406.662 Td /F1 9.8 Tf [(1992)] TJ ET 0.267 0.267 0.267 rg 177.927 418.332 80.585 0.750 re f 177.927 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 406.662 Td /F1 9.8 Tf [(USA)] TJ ET 0.267 0.267 0.267 rg 257.761 418.332 47.042 0.750 re f 257.761 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 406.662 Td /F1 9.8 Tf [(3945)] TJ ET 0.267 0.267 0.267 rg 304.053 418.332 57.366 0.750 re f 304.053 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 406.662 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 418.332 32.064 0.750 re f 360.669 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 406.662 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 418.332 57.366 0.750 re f 391.983 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 406.662 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 418.332 38.912 0.750 re f 448.598 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 406.662 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 418.332 55.953 0.750 re f 486.760 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 406.662 Td /F1 9.8 Tf [(208)] TJ ET 0.267 0.267 0.267 rg 541.963 418.332 38.912 0.750 re f 541.963 386.454 0.750 32.628 re f 580.125 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 406.662 Td /F1 9.8 Tf [(5.3)] TJ ET 0.267 0.267 0.267 rg 26.625 386.454 81.984 0.750 re f 26.625 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 374.784 Td /F1 9.8 Tf [(Morrison &)] TJ ET BT 31.875 361.822 Td /F1 9.8 Tf [(Nevin)] TJ ET 0.267 0.267 0.267 rg BT 59.828 362.404 Td /F4 8.7 Tf [(52)] TJ ET 0.271 0.267 0.267 rg BT 71.892 361.822 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 386.454 70.818 0.750 re f 107.859 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 374.784 Td /F1 9.8 Tf [(1993)] TJ ET 0.267 0.267 0.267 rg 177.927 386.454 80.585 0.750 re f 177.927 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 374.784 Td /F1 9.8 Tf [(N Ireland)] TJ ET 0.267 0.267 0.267 rg 257.761 386.454 47.042 0.750 re f 257.761 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 374.784 Td /F1 9.8 Tf [(12)] TJ ET 0.267 0.267 0.267 rg 304.053 386.454 57.366 0.750 re f 304.053 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 374.784 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 386.454 32.064 0.750 re f 360.669 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 374.784 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 386.454 57.366 0.750 re f 391.983 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 374.784 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 448.598 386.454 38.912 0.750 re f 448.598 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 374.784 Td /F1 9.8 Tf [(8.3)] TJ ET 0.267 0.267 0.267 rg 486.760 386.454 55.953 0.750 re f 486.760 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 374.784 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 541.963 386.454 38.912 0.750 re f 541.963 354.576 0.750 32.628 re f 580.125 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 374.784 Td /F1 9.8 Tf [(8.3)] TJ ET 0.267 0.267 0.267 rg 26.625 354.576 81.984 0.750 re f 26.625 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 339.844 Td /F1 9.8 Tf [(Roos et al)] TJ ET 0.267 0.267 0.267 rg BT 83.472 340.426 Td /F4 8.7 Tf [(53)] TJ ET 0.271 0.267 0.267 rg BT 95.536 339.844 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 354.576 70.818 0.750 re f 107.859 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 342.906 Td /F1 9.8 Tf [(1993)] TJ ET 0.267 0.267 0.267 rg 177.927 354.576 80.585 0.750 re f 177.927 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 342.906 Td /F1 9.8 Tf [(Netherlands)] TJ ET 0.267 0.267 0.267 rg 257.761 354.576 47.042 0.750 re f 257.761 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 342.906 Td /F1 9.8 Tf [(1106)] TJ ET 0.267 0.267 0.267 rg 304.053 354.576 57.366 0.750 re f 304.053 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 342.906 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 354.576 32.064 0.750 re f 360.669 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 342.906 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 354.576 57.366 0.750 re f 391.983 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 342.906 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 354.576 38.912 0.750 re f 448.598 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 342.906 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 354.576 55.953 0.750 re f 486.760 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 342.906 Td /F1 9.8 Tf [(6.5)] TJ ET 0.267 0.267 0.267 rg 541.963 354.576 38.912 0.750 re f 541.963 332.598 0.750 22.728 re f 580.125 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 342.906 Td /F1 9.8 Tf [(5.9)] TJ ET 0.267 0.267 0.267 rg 26.625 332.598 81.984 0.750 re f 26.625 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 320.928 Td /F1 9.8 Tf [(Simpson et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 308.548 Td /F4 8.7 Tf [(54)] TJ ET 0.271 0.267 0.267 rg BT 43.939 307.966 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 332.598 70.818 0.750 re f 107.859 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 320.928 Td /F1 9.8 Tf [(1993)] TJ ET 0.267 0.267 0.267 rg 177.927 332.598 80.585 0.750 re f 177.927 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 320.928 Td /F1 9.8 Tf [(Scotland)] TJ ET 0.267 0.267 0.267 rg 257.761 332.598 47.042 0.750 re f 257.761 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 320.928 Td /F1 9.8 Tf [(82)] TJ ET 0.267 0.267 0.267 rg 304.053 332.598 57.366 0.750 re f 304.053 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 320.928 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 332.598 32.064 0.750 re f 360.669 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 320.928 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 332.598 57.366 0.750 re f 391.983 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 320.928 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 448.598 332.598 38.912 0.750 re f 448.598 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 320.928 Td /F1 9.8 Tf [(3.7)] TJ ET 0.267 0.267 0.267 rg 486.760 332.598 55.953 0.750 re f 486.760 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 320.928 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 541.963 332.598 38.912 0.750 re f 541.963 300.720 0.750 32.628 re f 580.125 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 320.928 Td /F1 9.8 Tf [(3.7)] TJ ET 0.267 0.267 0.267 rg 26.625 300.720 81.984 0.750 re f 26.625 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 289.050 Td /F1 9.8 Tf [(Watt & Seller)] TJ ET 0.267 0.267 0.267 rg BT 31.875 276.670 Td /F4 8.7 Tf [(55)] TJ ET 0.271 0.267 0.267 rg BT 43.939 276.088 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 300.720 70.818 0.750 re f 107.859 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 289.050 Td /F1 9.8 Tf [(1993)] TJ ET 0.267 0.267 0.267 rg 177.927 300.720 80.585 0.750 re f 177.927 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 289.050 Td /F1 9.8 Tf [(England)] TJ ET 0.267 0.267 0.267 rg 257.761 300.720 47.042 0.750 re f 257.761 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 289.050 Td /F1 9.8 Tf [(101)] TJ ET 0.267 0.267 0.267 rg 304.053 300.720 57.366 0.750 re f 304.053 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 289.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 300.720 32.064 0.750 re f 360.669 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 289.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 300.720 57.366 0.750 re f 391.983 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 289.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 300.720 38.912 0.750 re f 448.598 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 289.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 300.720 55.953 0.750 re f 486.760 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 289.050 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 541.963 300.720 38.912 0.750 re f 541.963 268.842 0.750 32.628 re f 580.125 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 289.050 Td /F1 9.8 Tf [(4.0)] TJ ET 0.267 0.267 0.267 rg 26.625 268.842 81.984 0.750 re f 26.625 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 254.110 Td /F1 9.8 Tf [(Shiwach)] TJ ET 0.267 0.267 0.267 rg BT 75.555 254.692 Td /F4 8.7 Tf [(56)] TJ ET 0.271 0.267 0.267 rg BT 87.619 254.110 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 268.842 70.818 0.750 re f 107.859 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 257.172 Td /F1 9.8 Tf [(1994)] TJ ET 0.267 0.267 0.267 rg 177.927 268.842 80.585 0.750 re f 177.927 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 257.172 Td /F1 9.8 Tf [(England)] TJ ET 0.267 0.267 0.267 rg 257.761 268.842 47.042 0.750 re f 257.761 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 257.172 Td /F1 9.8 Tf [(135)] TJ ET 0.267 0.267 0.267 rg 304.053 268.842 57.366 0.750 re f 304.053 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 257.172 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 268.842 32.064 0.750 re f 360.669 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 257.172 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 268.842 57.366 0.750 re f 391.983 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 257.172 Td /F1 9.8 Tf [(8)] TJ ET 0.267 0.267 0.267 rg 448.598 268.842 38.912 0.750 re f 448.598 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 257.172 Td /F1 9.8 Tf [(5.9)] TJ ET 0.267 0.267 0.267 rg 486.760 268.842 55.953 0.750 re f 486.760 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 257.172 Td /F1 9.8 Tf [(8)] TJ ET 0.267 0.267 0.267 rg 541.963 268.842 38.912 0.750 re f 541.963 246.864 0.750 22.728 re f 580.125 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 257.172 Td /F1 9.8 Tf [(5.9)] TJ ET 0.267 0.267 0.267 rg 26.625 246.864 81.984 0.750 re f 26.625 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 235.194 Td /F1 9.8 Tf [(Morrison et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 222.814 Td /F4 8.7 Tf [(57)] TJ ET 0.271 0.267 0.267 rg BT 43.939 222.232 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 246.864 70.818 0.750 re f 107.859 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 235.194 Td /F1 9.8 Tf [(1995)] TJ ET 0.267 0.267 0.267 rg 177.927 246.864 80.585 0.750 re f 177.927 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 235.194 Td /F1 9.8 Tf [(N Ireland)] TJ ET 0.267 0.267 0.267 rg 257.761 246.864 47.042 0.750 re f 257.761 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 235.194 Td /F1 9.8 Tf [(101)] TJ ET 0.267 0.267 0.267 rg 304.053 246.864 57.366 0.750 re f 304.053 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 235.194 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 360.669 246.864 32.064 0.750 re f 360.669 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 235.194 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 391.983 246.864 57.366 0.750 re f 391.983 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 235.194 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 448.598 246.864 38.912 0.750 re f 448.598 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 235.194 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 486.760 246.864 55.953 0.750 re f 486.760 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 235.194 Td /F1 9.8 Tf [(6)] TJ ET 0.267 0.267 0.267 rg 541.963 246.864 38.912 0.750 re f 541.963 214.986 0.750 32.628 re f 580.125 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 235.194 Td /F1 9.8 Tf [(6)] TJ ET 0.267 0.267 0.267 rg 26.625 214.986 81.984 0.750 re f 26.625 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 203.316 Td /F1 9.8 Tf [(Sanchest et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 190.936 Td /F4 8.7 Tf [(59)] TJ ET 0.271 0.267 0.267 rg BT 43.939 190.354 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 214.986 70.818 0.750 re f 107.859 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 203.316 Td /F1 9.8 Tf [(1996)] TJ ET 0.267 0.267 0.267 rg 177.927 214.986 80.585 0.750 re f 177.927 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 203.316 Td /F1 9.8 Tf [(Spain)] TJ ET 0.267 0.267 0.267 rg 257.761 214.986 47.042 0.750 re f 257.761 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 203.316 Td /F1 9.8 Tf [(31)] TJ ET 0.267 0.267 0.267 rg 304.053 214.986 57.366 0.750 re f 304.053 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 203.316 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 214.986 32.064 0.750 re f 360.669 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 203.316 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 214.986 57.366 0.750 re f 391.983 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 203.316 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 448.598 214.986 38.912 0.750 re f 448.598 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 203.316 Td /F1 9.8 Tf [(12.9)] TJ ET 0.267 0.267 0.267 rg 486.760 214.986 55.953 0.750 re f 486.760 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 203.316 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 541.963 214.986 38.912 0.750 re f 541.963 183.108 0.750 32.628 re f 580.125 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 203.316 Td /F1 9.8 Tf [(12.9)] TJ ET 0.267 0.267 0.267 rg 26.625 183.108 81.984 0.750 re f 26.625 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 171.438 Td /F1 9.8 Tf [(Alonso et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 159.058 Td /F4 8.7 Tf [(58)] TJ ET 0.271 0.267 0.267 rg BT 43.939 158.476 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 183.108 70.818 0.750 re f 107.859 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 171.438 Td /F1 9.8 Tf [(1997)] TJ ET 0.267 0.267 0.267 rg 177.927 183.108 80.585 0.750 re f 177.927 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 171.438 Td /F1 9.8 Tf [(Mexico)] TJ ET 0.267 0.267 0.267 rg 257.761 183.108 47.042 0.750 re f 257.761 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 171.438 Td /F1 9.8 Tf [(83)] TJ ET 0.267 0.267 0.267 rg 304.053 183.108 57.366 0.750 re f 304.053 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 171.438 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 183.108 32.064 0.750 re f 360.669 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 171.438 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 183.108 57.366 0.750 re f 391.983 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 171.438 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 183.108 38.912 0.750 re f 448.598 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 171.438 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 183.108 55.953 0.750 re f 486.760 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 171.438 Td /F1 9.8 Tf [(6)] TJ ET 0.267 0.267 0.267 rg 541.963 183.108 38.912 0.750 re f 541.963 151.230 0.750 32.628 re f 580.125 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 171.438 Td /F1 9.8 Tf [(7.2)] TJ ET 0.267 0.267 0.267 rg 26.625 151.230 81.984 0.750 re f 26.625 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 139.560 Td /F1 9.8 Tf [(Siesling et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 127.180 Td /F4 8.7 Tf [(4)] TJ ET 0.271 0.267 0.267 rg BT 37.907 126.598 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 151.230 70.818 0.750 re f 107.859 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 139.560 Td /F1 9.8 Tf [(1997)] TJ ET 0.267 0.267 0.267 rg 177.927 151.230 80.585 0.750 re f 177.927 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 139.560 Td /F1 9.8 Tf [(Netherlands)] TJ ET 0.267 0.267 0.267 rg 257.761 151.230 47.042 0.750 re f 257.761 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 139.560 Td /F1 9.8 Tf [(2787)] TJ ET 0.267 0.267 0.267 rg 304.053 151.230 57.366 0.750 re f 304.053 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 139.560 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 151.230 32.064 0.750 re f 360.669 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 139.560 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 151.230 57.366 0.750 re f 391.983 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 139.560 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 151.230 38.912 0.750 re f 448.598 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 139.560 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 151.230 55.953 0.750 re f 486.760 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 139.560 Td /F1 9.8 Tf [(65)] TJ ET 0.267 0.267 0.267 rg 541.963 151.230 38.912 0.750 re f 541.963 119.352 0.750 32.628 re f 580.125 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 139.560 Td /F1 9.8 Tf [(2.3)] TJ ET 0.267 0.267 0.267 rg 26.625 119.352 81.984 0.750 re f 26.625 77.574 81.984 0.750 re f 26.625 77.574 0.750 42.528 re f 0.271 0.267 0.267 rg BT 31.875 107.682 Td /F1 9.8 Tf [(Gomez-)] TJ ET BT 31.875 94.720 Td /F1 9.8 Tf [(Totosa et al)] TJ ET 0.267 0.267 0.267 rg BT 89.351 95.302 Td /F4 8.7 Tf [(59)] TJ ET 0.271 0.267 0.267 rg BT 31.875 84.054 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 119.352 70.818 0.750 re f 107.859 77.574 70.818 0.750 re f 107.859 77.574 0.750 42.528 re f 0.271 0.267 0.267 rg BT 113.109 107.682 Td /F1 9.8 Tf [(1998)] TJ ET 0.267 0.267 0.267 rg 177.927 119.352 80.585 0.750 re f 177.927 77.574 80.585 0.750 re f 177.927 77.574 0.750 42.528 re f 0.271 0.267 0.267 rg BT 183.177 107.682 Td /F1 9.8 Tf [(Spain)] TJ ET 0.267 0.267 0.267 rg 257.761 119.352 47.042 0.750 re f 257.761 77.574 47.042 0.750 re f 257.761 77.574 0.750 42.528 re f 0.271 0.267 0.267 rg BT 263.011 107.682 Td /F1 9.8 Tf [(81)] TJ ET 0.267 0.267 0.267 rg 304.053 119.352 57.366 0.750 re f 304.053 77.574 57.366 0.750 re f 304.053 77.574 0.750 42.528 re f 0.271 0.267 0.267 rg BT 309.303 107.682 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 360.669 119.352 32.064 0.750 re f 360.669 77.574 32.064 0.750 re f 360.669 77.574 0.750 42.528 re f 0.271 0.267 0.267 rg BT 365.919 107.682 Td /F1 9.8 Tf [(1.2)] TJ ET 0.267 0.267 0.267 rg 391.983 119.352 57.366 0.750 re f 391.983 77.574 57.366 0.750 re f 391.983 77.574 0.750 42.528 re f 0.271 0.267 0.267 rg BT 397.233 107.682 Td /F1 9.8 Tf [(6)] TJ ET 0.267 0.267 0.267 rg 448.598 119.352 38.912 0.750 re f 448.598 77.574 38.912 0.750 re f 448.598 77.574 0.750 42.528 re f 0.271 0.267 0.267 rg BT 453.848 107.682 Td /F1 9.8 Tf [(7.4)] TJ ET 0.267 0.267 0.267 rg 486.760 119.352 55.953 0.750 re f 486.760 77.574 55.953 0.750 re f 486.760 77.574 0.750 42.528 re f 0.271 0.267 0.267 rg BT 492.010 107.682 Td /F1 9.8 Tf [(7)] TJ ET 0.267 0.267 0.267 rg 541.963 119.352 38.912 0.750 re f 541.963 77.574 38.912 0.750 re f 541.963 77.574 0.750 42.528 re f 580.125 77.574 0.750 42.528 re f 0.271 0.267 0.267 rg BT 547.213 107.682 Td /F1 9.8 Tf [(8.6)] TJ ET Q q 15.000 77.199 577.500 699.801 re W n 1.000 1.000 1.000 rg 26.250 77.199 555.000 699.801 re f 0.965 0.965 0.965 rg 27.000 745.737 81.234 31.263 re f 0.267 0.267 0.267 rg 26.625 745.362 0.750 31.638 re f 0.271 0.267 0.267 rg BT 31.500 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 108.234 745.737 70.068 31.263 re f 0.271 0.267 0.267 rg BT 112.734 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 178.302 745.737 79.835 31.263 re f 0.271 0.267 0.267 rg BT 182.802 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 258.136 745.737 46.292 31.263 re f 0.271 0.267 0.267 rg BT 262.636 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 304.428 745.737 56.616 31.263 re f 0.271 0.267 0.267 rg BT 308.928 764.645 Td /F4 9.8 Tf [(0 -10 )] TJ ET BT 308.928 749.201 Td /F4 9.8 Tf [(years)] TJ ET 0.965 0.965 0.965 rg 361.044 745.737 31.314 31.263 re f 0.271 0.267 0.267 rg BT 365.544 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 392.358 745.737 56.616 31.263 re f 0.271 0.267 0.267 rg BT 396.858 764.645 Td /F4 9.8 Tf [(11-20 )] TJ ET BT 396.858 749.201 Td /F4 9.8 Tf [(years)] TJ ET 0.965 0.965 0.965 rg 448.973 745.737 38.162 31.263 re f 0.271 0.267 0.267 rg BT 453.473 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 487.135 745.737 55.203 31.263 re f 0.271 0.267 0.267 rg BT 491.635 764.645 Td /F4 9.8 Tf [(Total )] TJ ET BT 491.635 749.201 Td /F4 9.8 Tf [(JHD)] TJ ET 0.965 0.965 0.965 rg 542.338 745.737 38.162 31.263 re f 0.267 0.267 0.267 rg 580.125 745.362 0.750 31.638 re f 0.271 0.267 0.267 rg BT 546.838 764.645 Td /F4 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 26.625 745.362 81.984 0.750 re f 26.625 713.484 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 733.692 Td /F1 9.8 Tf [(Farrer &)] TJ ET BT 31.875 720.730 Td /F1 9.8 Tf [(Conneally)] TJ ET 0.267 0.267 0.267 rg BT 80.177 721.312 Td /F4 8.7 Tf [(41)] TJ ET 0.271 0.267 0.267 rg BT 92.241 720.730 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 745.362 70.818 0.750 re f 107.859 713.484 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 733.692 Td /F1 9.8 Tf [(1985)] TJ ET 0.267 0.267 0.267 rg 177.927 745.362 80.585 0.750 re f 177.927 713.484 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 733.692 Td /F1 9.8 Tf [(USA)] TJ ET 0.267 0.267 0.267 rg 257.761 745.362 47.042 0.750 re f 257.761 713.484 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 733.692 Td /F1 9.8 Tf [(569)] TJ ET 0.267 0.267 0.267 rg 304.053 745.362 57.366 0.750 re f 304.053 713.484 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 733.692 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 360.669 745.362 32.064 0.750 re f 360.669 713.484 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 733.692 Td /F1 9.8 Tf [(0.7)] TJ ET 0.267 0.267 0.267 rg 391.983 745.362 57.366 0.750 re f 391.983 713.484 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 733.692 Td /F1 9.8 Tf [(24)] TJ ET 0.267 0.267 0.267 rg 448.598 745.362 38.912 0.750 re f 448.598 713.484 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 733.692 Td /F1 9.8 Tf [(4.2)] TJ ET 0.267 0.267 0.267 rg 486.760 745.362 55.953 0.750 re f 486.760 713.484 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 733.692 Td /F1 9.8 Tf [(28)] TJ ET 0.267 0.267 0.267 rg 541.963 745.362 38.912 0.750 re f 541.963 713.484 0.750 32.628 re f 580.125 713.484 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 733.692 Td /F1 9.8 Tf [(4.9)] TJ ET 0.267 0.267 0.267 rg 26.625 713.484 81.984 0.750 re f 26.625 681.606 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 701.814 Td /F1 9.8 Tf [(Hayden et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 689.434 Td /F4 8.7 Tf [(42)] TJ ET 0.271 0.267 0.267 rg BT 43.939 688.852 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 713.484 70.818 0.750 re f 107.859 681.606 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 701.814 Td /F1 9.8 Tf [(1985)] TJ ET 0.267 0.267 0.267 rg 177.927 713.484 80.585 0.750 re f 177.927 681.606 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 701.814 Td /F1 9.8 Tf [(USA)] TJ ET 0.267 0.267 0.267 rg 257.761 713.484 47.042 0.750 re f 257.761 681.606 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 701.814 Td /F1 9.8 Tf [(598)] TJ ET 0.267 0.267 0.267 rg 304.053 713.484 57.366 0.750 re f 304.053 681.606 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 701.814 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 713.484 32.064 0.750 re f 360.669 681.606 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 701.814 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 713.484 57.366 0.750 re f 391.983 681.606 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 701.814 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 713.484 38.912 0.750 re f 448.598 681.606 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 701.814 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 713.484 55.953 0.750 re f 486.760 681.606 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 701.814 Td /F1 9.8 Tf [(89)] TJ ET 0.267 0.267 0.267 rg 541.963 713.484 38.912 0.750 re f 541.963 681.606 0.750 32.628 re f 580.125 681.606 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 701.814 Td /F1 9.8 Tf [(14.9)] TJ ET 0.267 0.267 0.267 rg 26.625 681.606 81.984 0.750 re f 26.625 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 669.936 Td /F1 9.8 Tf [(Groppi et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 657.556 Td /F4 8.7 Tf [(43)] TJ ET 0.271 0.267 0.267 rg BT 43.939 656.974 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 681.606 70.818 0.750 re f 107.859 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 669.936 Td /F1 9.8 Tf [(1986)] TJ ET 0.267 0.267 0.267 rg 177.927 681.606 80.585 0.750 re f 177.927 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 669.936 Td /F1 9.8 Tf [(Italy)] TJ ET 0.267 0.267 0.267 rg 257.761 681.606 47.042 0.750 re f 257.761 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 669.936 Td /F1 9.8 Tf [(48)] TJ ET 0.267 0.267 0.267 rg 304.053 681.606 57.366 0.750 re f 304.053 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 669.936 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 681.606 32.064 0.750 re f 360.669 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 669.936 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 681.606 57.366 0.750 re f 391.983 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 669.936 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 681.606 38.912 0.750 re f 448.598 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 669.936 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 681.606 55.953 0.750 re f 486.760 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 669.936 Td /F1 9.8 Tf [(5)] TJ ET 0.267 0.267 0.267 rg 541.963 681.606 38.912 0.750 re f 541.963 649.728 0.750 32.628 re f 580.125 649.728 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 669.936 Td /F1 9.8 Tf [(10.4)] TJ ET 0.267 0.267 0.267 rg 26.625 649.728 81.984 0.750 re f 26.625 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 634.996 Td /F1 9.8 Tf [(Young et al)] TJ ET 0.267 0.267 0.267 rg BT 90.160 635.578 Td /F4 8.7 Tf [(44)] TJ ET 0.271 0.267 0.267 rg BT 31.875 624.330 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 649.728 70.818 0.750 re f 107.859 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 638.058 Td /F1 9.8 Tf [(1986)] TJ ET 0.267 0.267 0.267 rg 177.927 649.728 80.585 0.750 re f 177.927 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 638.058 Td /F1 9.8 Tf [(Venezueala)] TJ ET 0.267 0.267 0.267 rg 257.761 649.728 47.042 0.750 re f 257.761 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 638.058 Td /F1 9.8 Tf [(65)] TJ ET 0.267 0.267 0.267 rg 304.053 649.728 57.366 0.750 re f 304.053 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 638.058 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 360.669 649.728 32.064 0.750 re f 360.669 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 638.058 Td /F1 9.8 Tf [(1.5)] TJ ET 0.267 0.267 0.267 rg 391.983 649.728 57.366 0.750 re f 391.983 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 638.058 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 448.598 649.728 38.912 0.750 re f 448.598 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 638.058 Td /F1 9.8 Tf [(4.6)] TJ ET 0.267 0.267 0.267 rg 486.760 649.728 55.953 0.750 re f 486.760 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 638.058 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 541.963 649.728 38.912 0.750 re f 541.963 617.850 0.750 32.628 re f 580.125 617.850 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 638.058 Td /F1 9.8 Tf [(6.2)] TJ ET 0.267 0.267 0.267 rg 26.625 617.850 81.984 0.750 re f 26.625 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 606.180 Td /F1 9.8 Tf [(Folstein et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 593.800 Td /F4 8.7 Tf [(19)] TJ ET 0.271 0.267 0.267 rg BT 43.939 593.218 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 617.850 70.818 0.750 re f 107.859 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 606.180 Td /F1 9.8 Tf [(1987)] TJ ET 0.267 0.267 0.267 rg 177.927 617.850 80.585 0.750 re f 177.927 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 606.180 Td /F1 9.8 Tf [(USA)] TJ ET 0.267 0.267 0.267 rg 257.761 617.850 47.042 0.750 re f 257.761 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 606.180 Td /F1 9.8 Tf [(217)] TJ ET 0.267 0.267 0.267 rg 304.053 617.850 57.366 0.750 re f 304.053 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 606.180 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 617.850 32.064 0.750 re f 360.669 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 606.180 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 617.850 57.366 0.750 re f 391.983 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 606.180 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 617.850 38.912 0.750 re f 448.598 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 606.180 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 617.850 55.953 0.750 re f 486.760 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 606.180 Td /F1 9.8 Tf [(15)] TJ ET 0.267 0.267 0.267 rg 541.963 617.850 38.912 0.750 re f 541.963 585.972 0.750 32.628 re f 580.125 585.972 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 606.180 Td /F1 9.8 Tf [(6.9)] TJ ET 0.267 0.267 0.267 rg 26.625 585.972 81.984 0.750 re f 26.625 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 574.302 Td /F1 9.8 Tf [(Adams et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 561.922 Td /F4 8.7 Tf [(45)] TJ ET 0.271 0.267 0.267 rg BT 43.939 561.340 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 585.972 70.818 0.750 re f 107.859 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 574.302 Td /F1 9.8 Tf [(1988)] TJ ET 0.267 0.267 0.267 rg 177.927 585.972 80.585 0.750 re f 177.927 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 574.302 Td /F1 9.8 Tf [(USA)] TJ ET 0.267 0.267 0.267 rg 257.761 585.972 47.042 0.750 re f 257.761 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 574.302 Td /F1 9.8 Tf [(611)] TJ ET 0.267 0.267 0.267 rg 304.053 585.972 57.366 0.750 re f 304.053 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 574.302 Td /F1 9.8 Tf [(5)] TJ ET 0.267 0.267 0.267 rg 360.669 585.972 32.064 0.750 re f 360.669 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 574.302 Td /F1 9.8 Tf [(0.8)] TJ ET 0.267 0.267 0.267 rg 391.983 585.972 57.366 0.750 re f 391.983 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 574.302 Td /F1 9.8 Tf [(25)] TJ ET 0.267 0.267 0.267 rg 448.598 585.972 38.912 0.750 re f 448.598 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 574.302 Td /F1 9.8 Tf [(4.1)] TJ ET 0.267 0.267 0.267 rg 486.760 585.972 55.953 0.750 re f 486.760 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 574.302 Td /F1 9.8 Tf [(30)] TJ ET 0.267 0.267 0.267 rg 541.963 585.972 38.912 0.750 re f 541.963 554.094 0.750 32.628 re f 580.125 554.094 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 574.302 Td /F1 9.8 Tf [(4.9)] TJ ET 0.267 0.267 0.267 rg 26.625 554.094 81.984 0.750 re f 26.625 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 542.424 Td /F1 9.8 Tf [(Fromtali et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 530.044 Td /F4 8.7 Tf [(46)] TJ ET 0.271 0.267 0.267 rg BT 43.939 529.462 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 554.094 70.818 0.750 re f 107.859 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 542.424 Td /F1 9.8 Tf [(1990)] TJ ET 0.267 0.267 0.267 rg 177.927 554.094 80.585 0.750 re f 177.927 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 542.424 Td /F1 9.8 Tf [(Italy)] TJ ET 0.267 0.267 0.267 rg 257.761 554.094 47.042 0.750 re f 257.761 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 542.424 Td /F1 9.8 Tf [(299)] TJ ET 0.267 0.267 0.267 rg 304.053 554.094 57.366 0.750 re f 304.053 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 542.424 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 360.669 554.094 32.064 0.750 re f 360.669 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 542.424 Td /F1 9.8 Tf [(0.7)] TJ ET 0.267 0.267 0.267 rg 391.983 554.094 57.366 0.750 re f 391.983 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 542.424 Td /F1 9.8 Tf [(9)] TJ ET 0.267 0.267 0.267 rg 448.598 554.094 38.912 0.750 re f 448.598 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 542.424 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 486.760 554.094 55.953 0.750 re f 486.760 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 542.424 Td /F1 9.8 Tf [(11)] TJ ET 0.267 0.267 0.267 rg 541.963 554.094 38.912 0.750 re f 541.963 522.216 0.750 32.628 re f 580.125 522.216 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 542.424 Td /F1 9.8 Tf [(3.7)] TJ ET 0.267 0.267 0.267 rg 26.625 522.216 81.984 0.750 re f 26.625 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 510.546 Td /F1 9.8 Tf [(Pavomi et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 498.166 Td /F4 8.7 Tf [(47)] TJ ET 0.271 0.267 0.267 rg BT 43.939 497.584 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 522.216 70.818 0.750 re f 107.859 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 510.546 Td /F1 9.8 Tf [(1990)] TJ ET 0.267 0.267 0.267 rg 177.927 522.216 80.585 0.750 re f 177.927 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 510.546 Td /F1 9.8 Tf [(Italy)] TJ ET 0.267 0.267 0.267 rg 257.761 522.216 47.042 0.750 re f 257.761 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 510.546 Td /F1 9.8 Tf [(47)] TJ ET 0.267 0.267 0.267 rg 304.053 522.216 57.366 0.750 re f 304.053 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 510.546 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 522.216 32.064 0.750 re f 360.669 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 510.546 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 522.216 57.366 0.750 re f 391.983 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 510.546 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 448.598 522.216 38.912 0.750 re f 448.598 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 510.546 Td /F1 9.8 Tf [(3.1)] TJ ET 0.267 0.267 0.267 rg 486.760 522.216 55.953 0.750 re f 486.760 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 510.546 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 541.963 522.216 38.912 0.750 re f 541.963 490.338 0.750 32.628 re f 580.125 490.338 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 510.546 Td /F1 9.8 Tf [(2.1)] TJ ET 0.267 0.267 0.267 rg 26.625 490.338 81.984 0.750 re f 26.625 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 475.606 Td /F1 9.8 Tf [(Pridmore)] TJ ET 0.267 0.267 0.267 rg BT 79.231 476.188 Td /F4 8.7 Tf [(48)] TJ ET 0.271 0.267 0.267 rg BT 91.295 475.606 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 490.338 70.818 0.750 re f 107.859 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 478.668 Td /F1 9.8 Tf [(1990)] TJ ET 0.267 0.267 0.267 rg 177.927 490.338 80.585 0.750 re f 177.927 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 478.668 Td /F1 9.8 Tf [(Tasmania)] TJ ET 0.267 0.267 0.267 rg 257.761 490.338 47.042 0.750 re f 257.761 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 478.668 Td /F1 9.8 Tf [(48)] TJ ET 0.267 0.267 0.267 rg 304.053 490.338 57.366 0.750 re f 304.053 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 478.668 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 490.338 32.064 0.750 re f 360.669 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 478.668 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 490.338 57.366 0.750 re f 391.983 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 478.668 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 448.598 490.338 38.912 0.750 re f 448.598 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 478.668 Td /F1 9.8 Tf [(6.3)] TJ ET 0.267 0.267 0.267 rg 486.760 490.338 55.953 0.750 re f 486.760 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 478.668 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 541.963 490.338 38.912 0.750 re f 541.963 468.360 0.750 22.728 re f 580.125 468.360 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 478.668 Td /F1 9.8 Tf [(6.3)] TJ ET 0.267 0.267 0.267 rg 26.625 468.360 81.984 0.750 re f 26.625 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 453.628 Td /F1 9.8 Tf [(Roos et al)] TJ ET 0.267 0.267 0.267 rg BT 83.472 454.210 Td /F4 8.7 Tf [(49)] TJ ET 0.271 0.267 0.267 rg BT 95.536 453.628 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 468.360 70.818 0.750 re f 107.859 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 456.690 Td /F1 9.8 Tf [(1991)] TJ ET 0.267 0.267 0.267 rg 177.927 468.360 80.585 0.750 re f 177.927 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 456.690 Td /F1 9.8 Tf [(Netherlands)] TJ ET 0.267 0.267 0.267 rg 257.761 468.360 47.042 0.750 re f 257.761 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 456.690 Td /F1 9.8 Tf [(632)] TJ ET 0.267 0.267 0.267 rg 304.053 468.360 57.366 0.750 re f 304.053 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 456.690 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 468.360 32.064 0.750 re f 360.669 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 456.690 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 468.360 57.366 0.750 re f 391.983 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 456.690 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 468.360 38.912 0.750 re f 448.598 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 456.690 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 468.360 55.953 0.750 re f 486.760 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 456.690 Td /F1 9.8 Tf [(12)] TJ ET 0.267 0.267 0.267 rg 541.963 468.360 38.912 0.750 re f 541.963 446.382 0.750 22.728 re f 580.125 446.382 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 456.690 Td /F1 9.8 Tf [(1.9)] TJ ET 0.267 0.267 0.267 rg 26.625 446.382 81.984 0.750 re f 26.625 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 31.875 431.650 Td /F1 9.8 Tf [(Leung et al)] TJ ET 0.267 0.267 0.267 rg BT 86.563 432.232 Td /F4 8.7 Tf [(50)] TJ ET 0.271 0.267 0.267 rg BT 98.627 431.650 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 446.382 70.818 0.750 re f 107.859 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 113.109 434.712 Td /F1 9.8 Tf [(1992)] TJ ET 0.267 0.267 0.267 rg 177.927 446.382 80.585 0.750 re f 177.927 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 183.177 434.712 Td /F1 9.8 Tf [(China &)] TJ ET BT 183.177 424.812 Td /F1 9.8 Tf [(Hong Kong)] TJ ET 0.267 0.267 0.267 rg 257.761 446.382 47.042 0.750 re f 257.761 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 263.011 434.712 Td /F1 9.8 Tf [(89)] TJ ET 0.267 0.267 0.267 rg 304.053 446.382 57.366 0.750 re f 304.053 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 309.303 434.712 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 360.669 446.382 32.064 0.750 re f 360.669 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 365.919 434.712 Td /F1 9.8 Tf [(4.5)] TJ ET 0.267 0.267 0.267 rg 391.983 446.382 57.366 0.750 re f 391.983 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 397.233 434.712 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 448.598 446.382 38.912 0.750 re f 448.598 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 453.848 434.712 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 486.760 446.382 55.953 0.750 re f 486.760 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 492.010 434.712 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 541.963 446.382 38.912 0.750 re f 541.963 418.332 0.750 28.800 re f 580.125 418.332 0.750 28.800 re f 0.271 0.267 0.267 rg BT 547.213 434.712 Td /F1 9.8 Tf [(4.5)] TJ ET 0.267 0.267 0.267 rg 26.625 418.332 81.984 0.750 re f 26.625 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 403.600 Td /F1 9.8 Tf [(Ridley et al)] TJ ET 0.267 0.267 0.267 rg BT 89.839 404.182 Td /F4 8.7 Tf [(51)] TJ ET 0.271 0.267 0.267 rg BT 31.875 392.934 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 418.332 70.818 0.750 re f 107.859 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 406.662 Td /F1 9.8 Tf [(1992)] TJ ET 0.267 0.267 0.267 rg 177.927 418.332 80.585 0.750 re f 177.927 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 406.662 Td /F1 9.8 Tf [(USA)] TJ ET 0.267 0.267 0.267 rg 257.761 418.332 47.042 0.750 re f 257.761 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 406.662 Td /F1 9.8 Tf [(3945)] TJ ET 0.267 0.267 0.267 rg 304.053 418.332 57.366 0.750 re f 304.053 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 406.662 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 418.332 32.064 0.750 re f 360.669 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 406.662 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 418.332 57.366 0.750 re f 391.983 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 406.662 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 418.332 38.912 0.750 re f 448.598 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 406.662 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 418.332 55.953 0.750 re f 486.760 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 406.662 Td /F1 9.8 Tf [(208)] TJ ET 0.267 0.267 0.267 rg 541.963 418.332 38.912 0.750 re f 541.963 386.454 0.750 32.628 re f 580.125 386.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 406.662 Td /F1 9.8 Tf [(5.3)] TJ ET 0.267 0.267 0.267 rg 26.625 386.454 81.984 0.750 re f 26.625 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 374.784 Td /F1 9.8 Tf [(Morrison &)] TJ ET BT 31.875 361.822 Td /F1 9.8 Tf [(Nevin)] TJ ET 0.267 0.267 0.267 rg BT 59.828 362.404 Td /F4 8.7 Tf [(52)] TJ ET 0.271 0.267 0.267 rg BT 71.892 361.822 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 386.454 70.818 0.750 re f 107.859 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 374.784 Td /F1 9.8 Tf [(1993)] TJ ET 0.267 0.267 0.267 rg 177.927 386.454 80.585 0.750 re f 177.927 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 374.784 Td /F1 9.8 Tf [(N Ireland)] TJ ET 0.267 0.267 0.267 rg 257.761 386.454 47.042 0.750 re f 257.761 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 374.784 Td /F1 9.8 Tf [(12)] TJ ET 0.267 0.267 0.267 rg 304.053 386.454 57.366 0.750 re f 304.053 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 374.784 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 386.454 32.064 0.750 re f 360.669 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 374.784 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 386.454 57.366 0.750 re f 391.983 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 374.784 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 448.598 386.454 38.912 0.750 re f 448.598 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 374.784 Td /F1 9.8 Tf [(8.3)] TJ ET 0.267 0.267 0.267 rg 486.760 386.454 55.953 0.750 re f 486.760 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 374.784 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 541.963 386.454 38.912 0.750 re f 541.963 354.576 0.750 32.628 re f 580.125 354.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 374.784 Td /F1 9.8 Tf [(8.3)] TJ ET 0.267 0.267 0.267 rg 26.625 354.576 81.984 0.750 re f 26.625 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 339.844 Td /F1 9.8 Tf [(Roos et al)] TJ ET 0.267 0.267 0.267 rg BT 83.472 340.426 Td /F4 8.7 Tf [(53)] TJ ET 0.271 0.267 0.267 rg BT 95.536 339.844 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 354.576 70.818 0.750 re f 107.859 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 342.906 Td /F1 9.8 Tf [(1993)] TJ ET 0.267 0.267 0.267 rg 177.927 354.576 80.585 0.750 re f 177.927 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 342.906 Td /F1 9.8 Tf [(Netherlands)] TJ ET 0.267 0.267 0.267 rg 257.761 354.576 47.042 0.750 re f 257.761 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 342.906 Td /F1 9.8 Tf [(1106)] TJ ET 0.267 0.267 0.267 rg 304.053 354.576 57.366 0.750 re f 304.053 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 342.906 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 354.576 32.064 0.750 re f 360.669 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 342.906 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 354.576 57.366 0.750 re f 391.983 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 342.906 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 354.576 38.912 0.750 re f 448.598 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 342.906 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 354.576 55.953 0.750 re f 486.760 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 342.906 Td /F1 9.8 Tf [(6.5)] TJ ET 0.267 0.267 0.267 rg 541.963 354.576 38.912 0.750 re f 541.963 332.598 0.750 22.728 re f 580.125 332.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 342.906 Td /F1 9.8 Tf [(5.9)] TJ ET 0.267 0.267 0.267 rg 26.625 332.598 81.984 0.750 re f 26.625 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 320.928 Td /F1 9.8 Tf [(Simpson et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 308.548 Td /F4 8.7 Tf [(54)] TJ ET 0.271 0.267 0.267 rg BT 43.939 307.966 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 332.598 70.818 0.750 re f 107.859 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 320.928 Td /F1 9.8 Tf [(1993)] TJ ET 0.267 0.267 0.267 rg 177.927 332.598 80.585 0.750 re f 177.927 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 320.928 Td /F1 9.8 Tf [(Scotland)] TJ ET 0.267 0.267 0.267 rg 257.761 332.598 47.042 0.750 re f 257.761 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 320.928 Td /F1 9.8 Tf [(82)] TJ ET 0.267 0.267 0.267 rg 304.053 332.598 57.366 0.750 re f 304.053 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 320.928 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 332.598 32.064 0.750 re f 360.669 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 320.928 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 332.598 57.366 0.750 re f 391.983 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 320.928 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 448.598 332.598 38.912 0.750 re f 448.598 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 320.928 Td /F1 9.8 Tf [(3.7)] TJ ET 0.267 0.267 0.267 rg 486.760 332.598 55.953 0.750 re f 486.760 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 320.928 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 541.963 332.598 38.912 0.750 re f 541.963 300.720 0.750 32.628 re f 580.125 300.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 320.928 Td /F1 9.8 Tf [(3.7)] TJ ET 0.267 0.267 0.267 rg 26.625 300.720 81.984 0.750 re f 26.625 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 289.050 Td /F1 9.8 Tf [(Watt & Seller)] TJ ET 0.267 0.267 0.267 rg BT 31.875 276.670 Td /F4 8.7 Tf [(55)] TJ ET 0.271 0.267 0.267 rg BT 43.939 276.088 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 300.720 70.818 0.750 re f 107.859 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 289.050 Td /F1 9.8 Tf [(1993)] TJ ET 0.267 0.267 0.267 rg 177.927 300.720 80.585 0.750 re f 177.927 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 289.050 Td /F1 9.8 Tf [(England)] TJ ET 0.267 0.267 0.267 rg 257.761 300.720 47.042 0.750 re f 257.761 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 289.050 Td /F1 9.8 Tf [(101)] TJ ET 0.267 0.267 0.267 rg 304.053 300.720 57.366 0.750 re f 304.053 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 289.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 300.720 32.064 0.750 re f 360.669 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 289.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 300.720 57.366 0.750 re f 391.983 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 289.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 300.720 38.912 0.750 re f 448.598 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 289.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 300.720 55.953 0.750 re f 486.760 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 289.050 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 541.963 300.720 38.912 0.750 re f 541.963 268.842 0.750 32.628 re f 580.125 268.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 289.050 Td /F1 9.8 Tf [(4.0)] TJ ET 0.267 0.267 0.267 rg 26.625 268.842 81.984 0.750 re f 26.625 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 254.110 Td /F1 9.8 Tf [(Shiwach)] TJ ET 0.267 0.267 0.267 rg BT 75.555 254.692 Td /F4 8.7 Tf [(56)] TJ ET 0.271 0.267 0.267 rg BT 87.619 254.110 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 268.842 70.818 0.750 re f 107.859 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 257.172 Td /F1 9.8 Tf [(1994)] TJ ET 0.267 0.267 0.267 rg 177.927 268.842 80.585 0.750 re f 177.927 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 257.172 Td /F1 9.8 Tf [(England)] TJ ET 0.267 0.267 0.267 rg 257.761 268.842 47.042 0.750 re f 257.761 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 257.172 Td /F1 9.8 Tf [(135)] TJ ET 0.267 0.267 0.267 rg 304.053 268.842 57.366 0.750 re f 304.053 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 257.172 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 268.842 32.064 0.750 re f 360.669 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 257.172 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 268.842 57.366 0.750 re f 391.983 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 257.172 Td /F1 9.8 Tf [(8)] TJ ET 0.267 0.267 0.267 rg 448.598 268.842 38.912 0.750 re f 448.598 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 257.172 Td /F1 9.8 Tf [(5.9)] TJ ET 0.267 0.267 0.267 rg 486.760 268.842 55.953 0.750 re f 486.760 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 257.172 Td /F1 9.8 Tf [(8)] TJ ET 0.267 0.267 0.267 rg 541.963 268.842 38.912 0.750 re f 541.963 246.864 0.750 22.728 re f 580.125 246.864 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 257.172 Td /F1 9.8 Tf [(5.9)] TJ ET 0.267 0.267 0.267 rg 26.625 246.864 81.984 0.750 re f 26.625 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 235.194 Td /F1 9.8 Tf [(Morrison et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 222.814 Td /F4 8.7 Tf [(57)] TJ ET 0.271 0.267 0.267 rg BT 43.939 222.232 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 246.864 70.818 0.750 re f 107.859 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 235.194 Td /F1 9.8 Tf [(1995)] TJ ET 0.267 0.267 0.267 rg 177.927 246.864 80.585 0.750 re f 177.927 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 235.194 Td /F1 9.8 Tf [(N Ireland)] TJ ET 0.267 0.267 0.267 rg 257.761 246.864 47.042 0.750 re f 257.761 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 235.194 Td /F1 9.8 Tf [(101)] TJ ET 0.267 0.267 0.267 rg 304.053 246.864 57.366 0.750 re f 304.053 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 235.194 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 360.669 246.864 32.064 0.750 re f 360.669 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 235.194 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 391.983 246.864 57.366 0.750 re f 391.983 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 235.194 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 448.598 246.864 38.912 0.750 re f 448.598 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 235.194 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 486.760 246.864 55.953 0.750 re f 486.760 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 235.194 Td /F1 9.8 Tf [(6)] TJ ET 0.267 0.267 0.267 rg 541.963 246.864 38.912 0.750 re f 541.963 214.986 0.750 32.628 re f 580.125 214.986 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 235.194 Td /F1 9.8 Tf [(6)] TJ ET 0.267 0.267 0.267 rg 26.625 214.986 81.984 0.750 re f 26.625 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 203.316 Td /F1 9.8 Tf [(Sanchest et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 190.936 Td /F4 8.7 Tf [(59)] TJ ET 0.271 0.267 0.267 rg BT 43.939 190.354 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 214.986 70.818 0.750 re f 107.859 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 203.316 Td /F1 9.8 Tf [(1996)] TJ ET 0.267 0.267 0.267 rg 177.927 214.986 80.585 0.750 re f 177.927 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 203.316 Td /F1 9.8 Tf [(Spain)] TJ ET 0.267 0.267 0.267 rg 257.761 214.986 47.042 0.750 re f 257.761 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 203.316 Td /F1 9.8 Tf [(31)] TJ ET 0.267 0.267 0.267 rg 304.053 214.986 57.366 0.750 re f 304.053 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 203.316 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 214.986 32.064 0.750 re f 360.669 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 203.316 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 214.986 57.366 0.750 re f 391.983 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 203.316 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 448.598 214.986 38.912 0.750 re f 448.598 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 203.316 Td /F1 9.8 Tf [(12.9)] TJ ET 0.267 0.267 0.267 rg 486.760 214.986 55.953 0.750 re f 486.760 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 203.316 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 541.963 214.986 38.912 0.750 re f 541.963 183.108 0.750 32.628 re f 580.125 183.108 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 203.316 Td /F1 9.8 Tf [(12.9)] TJ ET 0.267 0.267 0.267 rg 26.625 183.108 81.984 0.750 re f 26.625 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 171.438 Td /F1 9.8 Tf [(Alonso et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 159.058 Td /F4 8.7 Tf [(58)] TJ ET 0.271 0.267 0.267 rg BT 43.939 158.476 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 183.108 70.818 0.750 re f 107.859 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 171.438 Td /F1 9.8 Tf [(1997)] TJ ET 0.267 0.267 0.267 rg 177.927 183.108 80.585 0.750 re f 177.927 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 171.438 Td /F1 9.8 Tf [(Mexico)] TJ ET 0.267 0.267 0.267 rg 257.761 183.108 47.042 0.750 re f 257.761 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 171.438 Td /F1 9.8 Tf [(83)] TJ ET 0.267 0.267 0.267 rg 304.053 183.108 57.366 0.750 re f 304.053 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 171.438 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 183.108 32.064 0.750 re f 360.669 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 171.438 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 183.108 57.366 0.750 re f 391.983 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 171.438 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 183.108 38.912 0.750 re f 448.598 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 171.438 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 183.108 55.953 0.750 re f 486.760 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 171.438 Td /F1 9.8 Tf [(6)] TJ ET 0.267 0.267 0.267 rg 541.963 183.108 38.912 0.750 re f 541.963 151.230 0.750 32.628 re f 580.125 151.230 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 171.438 Td /F1 9.8 Tf [(7.2)] TJ ET 0.267 0.267 0.267 rg 26.625 151.230 81.984 0.750 re f 26.625 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 139.560 Td /F1 9.8 Tf [(Siesling et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 127.180 Td /F4 8.7 Tf [(4)] TJ ET 0.271 0.267 0.267 rg BT 37.907 126.598 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 151.230 70.818 0.750 re f 107.859 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 139.560 Td /F1 9.8 Tf [(1997)] TJ ET 0.267 0.267 0.267 rg 177.927 151.230 80.585 0.750 re f 177.927 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 139.560 Td /F1 9.8 Tf [(Netherlands)] TJ ET 0.267 0.267 0.267 rg 257.761 151.230 47.042 0.750 re f 257.761 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 139.560 Td /F1 9.8 Tf [(2787)] TJ ET 0.267 0.267 0.267 rg 304.053 151.230 57.366 0.750 re f 304.053 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 139.560 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 151.230 32.064 0.750 re f 360.669 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 139.560 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 151.230 57.366 0.750 re f 391.983 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 139.560 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 151.230 38.912 0.750 re f 448.598 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 139.560 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 151.230 55.953 0.750 re f 486.760 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 139.560 Td /F1 9.8 Tf [(65)] TJ ET 0.267 0.267 0.267 rg 541.963 151.230 38.912 0.750 re f 541.963 119.352 0.750 32.628 re f 580.125 119.352 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 139.560 Td /F1 9.8 Tf [(2.3)] TJ ET 0.267 0.267 0.267 rg 26.625 119.352 81.984 0.750 re f 26.625 77.574 81.984 0.750 re f 26.625 77.574 0.750 42.528 re f 0.271 0.267 0.267 rg BT 31.875 107.682 Td /F1 9.8 Tf [(Gomez-)] TJ ET BT 31.875 94.720 Td /F1 9.8 Tf [(Totosa et al)] TJ ET 0.267 0.267 0.267 rg BT 89.351 95.302 Td /F4 8.7 Tf [(59)] TJ ET 0.271 0.267 0.267 rg BT 31.875 84.054 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 119.352 70.818 0.750 re f 107.859 77.574 70.818 0.750 re f 107.859 77.574 0.750 42.528 re f 0.271 0.267 0.267 rg BT 113.109 107.682 Td /F1 9.8 Tf [(1998)] TJ ET 0.267 0.267 0.267 rg 177.927 119.352 80.585 0.750 re f 177.927 77.574 80.585 0.750 re f 177.927 77.574 0.750 42.528 re f 0.271 0.267 0.267 rg BT 183.177 107.682 Td /F1 9.8 Tf [(Spain)] TJ ET 0.267 0.267 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611.220 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 448.598 622.890 38.912 0.750 re f 448.598 600.912 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 611.220 Td /F1 9.8 Tf [(10)] TJ ET 0.267 0.267 0.267 rg 486.760 622.890 55.953 0.750 re f 486.760 600.912 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 611.220 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 541.963 622.890 38.912 0.750 re f 541.963 600.912 0.750 22.728 re f 580.125 600.912 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 611.220 Td /F1 9.8 Tf [(10)] TJ ET 0.267 0.267 0.267 rg 26.625 600.912 81.984 0.750 re f 26.625 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 589.242 Td /F1 9.8 Tf [(Raskin et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 576.862 Td /F4 8.7 Tf [(64)] TJ ET 0.271 0.267 0.267 rg BT 43.939 576.280 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 600.912 70.818 0.750 re f 107.859 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 589.242 Td /F1 9.8 Tf [(2000)] TJ ET 0.267 0.267 0.267 rg 177.927 600.912 80.585 0.750 re f 177.927 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 589.242 Td /F1 9.8 Tf [(Brazil)] TJ ET 0.267 0.267 0.267 rg 257.761 600.912 47.042 0.750 re f 257.761 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 589.242 Td /F1 9.8 Tf [(59)] TJ ET 0.267 0.267 0.267 rg 304.053 600.912 57.366 0.750 re f 304.053 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 589.242 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 360.669 600.912 32.064 0.750 re f 360.669 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 589.242 Td /F1 9.8 Tf [(5.1)] TJ ET 0.267 0.267 0.267 rg 391.983 600.912 57.366 0.750 re f 391.983 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 589.242 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 448.598 600.912 38.912 0.750 re f 448.598 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 589.242 Td /F1 9.8 Tf [(6.8)] TJ ET 0.267 0.267 0.267 rg 486.760 600.912 55.953 0.750 re f 486.760 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 589.242 Td /F1 9.8 Tf [(7)] TJ ET 0.267 0.267 0.267 rg 541.963 600.912 38.912 0.750 re f 541.963 569.034 0.750 32.628 re f 580.125 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 589.242 Td /F1 9.8 Tf [(11.9)] TJ ET 0.267 0.267 0.267 rg 26.625 569.034 81.984 0.750 re f 26.625 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 557.364 Td /F1 9.8 Tf [(Rasmussen )] TJ ET BT 31.875 544.402 Td /F1 9.8 Tf [(et al)] TJ ET 0.267 0.267 0.267 rg BT 53.481 544.984 Td /F4 8.7 Tf [(65)] TJ ET 0.271 0.267 0.267 rg BT 65.545 544.402 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 569.034 70.818 0.750 re f 107.859 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 557.364 Td /F1 9.8 Tf [(2000)] TJ ET 0.267 0.267 0.267 rg 177.927 569.034 80.585 0.750 re f 177.927 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 557.364 Td /F1 9.8 Tf [(Mexico)] TJ ET 0.267 0.267 0.267 rg 257.761 569.034 47.042 0.750 re f 257.761 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 557.364 Td /F1 9.8 Tf [(364)] TJ ET 0.267 0.267 0.267 rg 304.053 569.034 57.366 0.750 re f 304.053 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 557.364 Td /F1 9.8 Tf [(7)] TJ ET 0.267 0.267 0.267 rg 360.669 569.034 32.064 0.750 re f 360.669 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 557.364 Td /F1 9.8 Tf [(1.9)] TJ ET 0.267 0.267 0.267 rg 391.983 569.034 57.366 0.750 re f 391.983 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 557.364 Td /F1 9.8 Tf [(18)] TJ ET 0.267 0.267 0.267 rg 448.598 569.034 38.912 0.750 re f 448.598 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 557.364 Td /F1 9.8 Tf [(4.9)] TJ ET 0.267 0.267 0.267 rg 486.760 569.034 55.953 0.750 re f 486.760 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 557.364 Td /F1 9.8 Tf [(25)] TJ ET 0.267 0.267 0.267 rg 541.963 569.034 38.912 0.750 re f 541.963 537.156 0.750 32.628 re f 580.125 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 557.364 Td /F1 9.8 Tf [(6.9)] TJ ET 0.267 0.267 0.267 rg 26.625 537.156 81.984 0.750 re f 26.625 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 525.486 Td /F1 9.8 Tf [(Almqvist et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 513.106 Td /F4 8.7 Tf [(66)] TJ ET 0.271 0.267 0.267 rg BT 43.939 512.524 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 537.156 70.818 0.750 re f 107.859 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 525.486 Td /F1 9.8 Tf [(2001)] TJ ET 0.267 0.267 0.267 rg 177.927 537.156 80.585 0.750 re f 177.927 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 525.486 Td /F1 9.8 Tf [(Canada)] TJ ET 0.267 0.267 0.267 rg 257.761 537.156 47.042 0.750 re f 257.761 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 525.486 Td /F1 9.8 Tf [(102)] TJ ET 0.267 0.267 0.267 rg 304.053 537.156 57.366 0.750 re f 304.053 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 525.486 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 537.156 32.064 0.750 re f 360.669 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 525.486 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 537.156 57.366 0.750 re f 391.983 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 525.486 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 448.598 537.156 38.912 0.750 re f 448.598 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 525.486 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 486.760 537.156 55.953 0.750 re f 486.760 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 525.486 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 541.963 537.156 38.912 0.750 re f 541.963 505.278 0.750 32.628 re f 580.125 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 525.486 Td /F1 9.8 Tf [(2.0)] TJ ET 0.267 0.267 0.267 rg 26.625 505.278 81.984 0.750 re f 26.625 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 493.608 Td /F1 9.8 Tf [(Murgod et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 481.228 Td /F4 8.7 Tf [(68)] TJ ET 0.271 0.267 0.267 rg BT 43.939 480.646 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 505.278 70.818 0.750 re f 107.859 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 493.608 Td /F1 9.8 Tf [(2001)] TJ ET 0.267 0.267 0.267 rg 177.927 505.278 80.585 0.750 re f 177.927 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 493.608 Td /F1 9.8 Tf [(India)] TJ ET 0.267 0.267 0.267 rg 257.761 505.278 47.042 0.750 re f 257.761 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 493.608 Td /F1 9.8 Tf [(26)] TJ ET 0.267 0.267 0.267 rg 304.053 505.278 57.366 0.750 re f 304.053 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 493.608 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 505.278 32.064 0.750 re f 360.669 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 493.608 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 505.278 57.366 0.750 re f 391.983 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 493.608 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 505.278 38.912 0.750 re f 448.598 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 493.608 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 505.278 55.953 0.750 re f 486.760 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 493.608 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 541.963 505.278 38.912 0.750 re f 541.963 473.400 0.750 32.628 re f 580.125 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 493.608 Td /F1 9.8 Tf [(15.4)] TJ ET 0.267 0.267 0.267 rg 26.625 473.400 81.984 0.750 re f 26.625 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 461.730 Td /F1 9.8 Tf [(Maat Kievit et )] TJ ET BT 31.875 448.768 Td /F1 9.8 Tf [(al)] TJ ET 0.267 0.267 0.267 rg BT 40.562 449.350 Td /F4 8.7 Tf [(68)] TJ ET 0.271 0.267 0.267 rg BT 52.626 448.768 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 473.400 70.818 0.750 re f 107.859 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 461.730 Td /F1 9.8 Tf [(2002)] TJ ET 0.267 0.267 0.267 rg 177.927 473.400 80.585 0.750 re f 177.927 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 461.730 Td /F1 9.8 Tf [(Netherlands)] TJ ET 0.267 0.267 0.267 rg 257.761 473.400 47.042 0.750 re f 257.761 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 461.730 Td /F1 9.8 Tf [(755)] TJ ET 0.267 0.267 0.267 rg 304.053 473.400 57.366 0.750 re f 304.053 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 461.730 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 473.400 32.064 0.750 re f 360.669 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 461.730 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 473.400 57.366 0.750 re f 391.983 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 461.730 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 473.400 38.912 0.750 re f 448.598 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 461.730 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 473.400 55.953 0.750 re f 486.760 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 461.730 Td /F1 9.8 Tf [(18)] TJ ET 0.267 0.267 0.267 rg 541.963 473.400 38.912 0.750 re f 541.963 441.522 0.750 32.628 re f 580.125 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 461.730 Td /F1 9.8 Tf [(3.0)] TJ ET 0.267 0.267 0.267 rg 26.625 441.522 81.984 0.750 re f 26.625 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 31.875 429.852 Td /F1 9.8 Tf [(Akbas )] TJ ET BT 31.875 419.952 Td /F1 9.8 Tf [(Erginel-)] TJ ET BT 31.875 406.990 Td /F1 9.8 Tf [(Unaltuna)] TJ ET 0.267 0.267 0.267 rg BT 76.042 407.572 Td /F4 8.7 Tf [(69)] TJ ET 0.271 0.267 0.267 rg BT 88.107 406.990 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 441.522 70.818 0.750 re f 107.859 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 113.109 429.852 Td /F1 9.8 Tf [(2003)] TJ ET 0.267 0.267 0.267 rg 177.927 441.522 80.585 0.750 re f 177.927 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 183.177 429.852 Td /F1 9.8 Tf [(Turkey)] TJ ET 0.267 0.267 0.267 rg 257.761 441.522 47.042 0.750 re f 257.761 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 263.011 429.852 Td /F1 9.8 Tf [(127)] TJ ET 0.267 0.267 0.267 rg 304.053 441.522 57.366 0.750 re f 304.053 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 309.303 429.852 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 360.669 441.522 32.064 0.750 re f 360.669 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 365.919 429.852 Td /F1 9.8 Tf [(0.8)] TJ ET 0.267 0.267 0.267 rg 391.983 441.522 57.366 0.750 re f 391.983 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 397.233 429.852 Td /F1 9.8 Tf [(7)] TJ ET 0.267 0.267 0.267 rg 448.598 441.522 38.912 0.750 re f 448.598 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 453.848 429.852 Td /F1 9.8 Tf [(5.5)] TJ ET 0.267 0.267 0.267 rg 486.760 441.522 55.953 0.750 re f 486.760 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 492.010 429.852 Td /F1 9.8 Tf [(8)] TJ ET 0.267 0.267 0.267 rg 541.963 441.522 38.912 0.750 re f 541.963 399.744 0.750 42.528 re f 580.125 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 547.213 429.852 Td /F1 9.8 Tf [(6.3)] TJ ET 0.267 0.267 0.267 rg 26.625 399.744 81.984 0.750 re f 26.625 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 388.074 Td /F1 9.8 Tf [(Creighton et )] TJ ET BT 31.875 375.112 Td /F1 9.8 Tf [(al)] TJ ET 0.267 0.267 0.267 rg BT 40.562 375.694 Td /F4 8.7 Tf [(71)] TJ ET 107.859 399.744 70.818 0.750 re f 107.859 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 388.074 Td /F1 9.8 Tf [(2003)] TJ ET 0.267 0.267 0.267 rg 177.927 399.744 80.585 0.750 re f 177.927 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 388.074 Td /F1 9.8 Tf [(Canada)] TJ ET 0.267 0.267 0.267 rg 257.761 399.744 47.042 0.750 re f 257.761 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 388.074 Td /F1 9.8 Tf [(282)] TJ ET 0.267 0.267 0.267 rg 304.053 399.744 57.366 0.750 re f 304.053 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 388.074 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 399.744 32.064 0.750 re f 360.669 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 388.074 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 399.744 57.366 0.750 re f 391.983 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 388.074 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 399.744 38.912 0.750 re f 448.598 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 388.074 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 399.744 55.953 0.750 re f 486.760 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 388.074 Td /F1 9.8 Tf [(5)] TJ ET 0.267 0.267 0.267 rg 541.963 399.744 38.912 0.750 re f 541.963 367.866 0.750 32.628 re f 580.125 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 388.074 Td /F1 9.8 Tf [(1.8)] TJ ET 0.267 0.267 0.267 rg 26.625 367.866 81.984 0.750 re f 26.625 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 31.875 356.196 Td /F1 9.8 Tf [(do Como )] TJ ET BT 31.875 346.296 Td /F1 9.8 Tf [(Costa)] TJ ET BT 31.875 333.334 Td /F1 9.8 Tf [(et al)] TJ ET 0.267 0.267 0.267 rg BT 53.481 333.916 Td /F4 8.7 Tf [(72)] TJ ET 107.859 367.866 70.818 0.750 re f 107.859 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 113.109 356.196 Td /F1 9.8 Tf [(2003)] TJ ET 0.267 0.267 0.267 rg 177.927 367.866 80.585 0.750 re f 177.927 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 183.177 356.196 Td /F1 9.8 Tf [(Portugaul)] TJ ET 0.267 0.267 0.267 rg 257.761 367.866 47.042 0.750 re f 257.761 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 263.011 356.196 Td /F1 9.8 Tf [(120)] TJ ET 0.267 0.267 0.267 rg 304.053 367.866 57.366 0.750 re f 304.053 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 309.303 356.196 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 360.669 367.866 32.064 0.750 re f 360.669 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 365.919 356.196 Td /F1 9.8 Tf [(2.5)] TJ ET 0.267 0.267 0.267 rg 391.983 367.866 57.366 0.750 re f 391.983 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 397.233 356.196 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 448.598 367.866 38.912 0.750 re f 448.598 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 453.848 356.196 Td /F1 9.8 Tf [(0.8)] TJ ET 0.267 0.267 0.267 rg 486.760 367.866 55.953 0.750 re f 486.760 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 492.010 356.196 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 541.963 367.866 38.912 0.750 re f 541.963 326.088 0.750 42.528 re f 580.125 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 547.213 356.196 Td /F1 9.8 Tf [(3.3)] TJ ET 0.267 0.267 0.267 rg 26.625 326.088 81.984 0.750 re f 26.625 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 314.418 Td /F1 9.8 Tf [(Cannella et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 302.038 Td /F4 8.7 Tf [(73)] TJ ET 107.859 326.088 70.818 0.750 re f 107.859 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 314.418 Td /F1 9.8 Tf [(2004)] TJ ET 0.267 0.267 0.267 rg 177.927 326.088 80.585 0.750 re f 177.927 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 314.418 Td /F1 9.8 Tf [(Italy)] TJ ET 0.267 0.267 0.267 rg 257.761 326.088 47.042 0.750 re f 257.761 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 314.418 Td /F1 9.8 Tf [(524)] TJ ET 0.267 0.267 0.267 rg 304.053 326.088 57.366 0.750 re f 304.053 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 314.418 Td /F1 9.8 Tf [(5)] TJ ET 0.267 0.267 0.267 rg 360.669 326.088 32.064 0.750 re f 360.669 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 314.418 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 391.983 326.088 57.366 0.750 re f 391.983 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 314.418 Td /F1 9.8 Tf [(52)] TJ ET 0.267 0.267 0.267 rg 448.598 326.088 38.912 0.750 re f 448.598 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 314.418 Td /F1 9.8 Tf [(9.9)] TJ ET 0.267 0.267 0.267 rg 486.760 326.088 55.953 0.750 re f 486.760 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 314.418 Td /F1 9.8 Tf [(57)] TJ ET 0.267 0.267 0.267 rg 541.963 326.088 38.912 0.750 re f 541.963 294.210 0.750 32.628 re f 580.125 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 314.418 Td /F1 9.8 Tf [(10.9)] TJ ET 0.267 0.267 0.267 rg 26.625 294.210 81.984 0.750 re f 26.625 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 282.540 Td /F1 9.8 Tf [(Wexler et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 270.160 Td /F4 8.7 Tf [(10)] TJ ET 0.271 0.267 0.267 rg BT 43.939 269.578 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 294.210 70.818 0.750 re f 107.859 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 282.540 Td /F1 9.8 Tf [(2004)] TJ ET 0.267 0.267 0.267 rg 177.927 294.210 80.585 0.750 re f 177.927 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 282.540 Td /F1 9.8 Tf [(Venezueala)] TJ ET 0.267 0.267 0.267 rg 257.761 294.210 47.042 0.750 re f 257.761 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 282.540 Td /F1 9.8 Tf [(443)] TJ ET 0.267 0.267 0.267 rg 304.053 294.210 57.366 0.750 re f 304.053 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 282.540 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 294.210 32.064 0.750 re f 360.669 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 282.540 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 294.210 57.366 0.750 re f 391.983 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 282.540 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 294.210 38.912 0.750 re f 448.598 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 282.540 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 294.210 55.953 0.750 re f 486.760 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 282.540 Td /F1 9.8 Tf [(40)] TJ ET 0.267 0.267 0.267 rg 541.963 294.210 38.912 0.750 re f 541.963 262.332 0.750 32.628 re f 580.125 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 282.540 Td /F1 9.8 Tf [(9.0)] TJ ET 0.267 0.267 0.267 rg 26.625 262.332 81.984 0.750 re f 26.625 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 250.662 Td /F1 9.8 Tf [(Ramos-Aroyo )] TJ ET BT 31.875 237.700 Td /F1 9.8 Tf [(et al)] TJ ET 0.267 0.267 0.267 rg BT 53.481 238.282 Td /F4 8.7 Tf [(74)] TJ ET 0.271 0.267 0.267 rg BT 65.545 237.700 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 262.332 70.818 0.750 re f 107.859 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 250.662 Td /F1 9.8 Tf [(2005)] TJ ET 0.267 0.267 0.267 rg 177.927 262.332 80.585 0.750 re f 177.927 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 250.662 Td /F1 9.8 Tf [(Spain)] TJ ET 0.267 0.267 0.267 rg 257.761 262.332 47.042 0.750 re f 257.761 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 250.662 Td /F1 9.8 Tf [(112)] TJ ET 0.267 0.267 0.267 rg 304.053 262.332 57.366 0.750 re f 304.053 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 250.662 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 262.332 32.064 0.750 re f 360.669 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 250.662 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 262.332 57.366 0.750 re f 391.983 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 250.662 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 262.332 38.912 0.750 re f 448.598 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 250.662 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 262.332 55.953 0.750 re f 486.760 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 250.662 Td /F1 9.8 Tf [(7)] TJ ET 0.267 0.267 0.267 rg 541.963 262.332 38.912 0.750 re f 541.963 230.454 0.750 32.628 re f 580.125 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 250.662 Td /F1 9.8 Tf [(6.3)] TJ ET 0.267 0.267 0.267 rg 26.625 230.454 81.984 0.750 re f 26.625 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 218.784 Td /F1 9.8 Tf [(Ruocco et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 206.404 Td /F4 8.7 Tf [(74)] TJ ET 0.271 0.267 0.267 rg BT 43.939 205.822 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 230.454 70.818 0.750 re f 107.859 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 218.784 Td /F1 9.8 Tf [(2006)] TJ ET 0.267 0.267 0.267 rg 177.927 230.454 80.585 0.750 re f 177.927 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 218.784 Td /F1 9.8 Tf [(Brazil)] TJ ET 0.267 0.267 0.267 rg 257.761 230.454 47.042 0.750 re f 257.761 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 218.784 Td /F1 9.8 Tf [(50)] TJ ET 0.267 0.267 0.267 rg 304.053 230.454 57.366 0.750 re f 304.053 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 218.784 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 360.669 230.454 32.064 0.750 re f 360.669 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 218.784 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 391.983 230.454 57.366 0.750 re f 391.983 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 218.784 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 448.598 230.454 38.912 0.750 re f 448.598 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 218.784 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 486.760 230.454 55.953 0.750 re f 486.760 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 218.784 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 541.963 230.454 38.912 0.750 re f 541.963 198.576 0.750 32.628 re f 580.125 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 218.784 Td /F1 9.8 Tf [(8.0)] TJ ET 0.267 0.267 0.267 rg 26.625 198.576 81.984 0.750 re f 26.625 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 183.844 Td /F1 9.8 Tf [(Ribai et al)] TJ ET 0.267 0.267 0.267 rg BT 84.047 184.426 Td /F4 8.7 Tf [(6)] TJ ET 0.271 0.267 0.267 rg BT 90.079 183.844 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 198.576 70.818 0.750 re f 107.859 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 186.906 Td /F1 9.8 Tf [(2007)] TJ ET 0.267 0.267 0.267 rg 177.927 198.576 80.585 0.750 re f 177.927 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 186.906 Td /F1 9.8 Tf [(France)] TJ ET 0.267 0.267 0.267 rg 257.761 198.576 47.042 0.750 re f 257.761 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 186.906 Td /F1 9.8 Tf [(1453)] TJ ET 0.267 0.267 0.267 rg 304.053 198.576 57.366 0.750 re f 304.053 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 186.906 Td /F1 9.8 Tf [(8)] TJ ET 0.267 0.267 0.267 rg 360.669 198.576 32.064 0.750 re f 360.669 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 186.906 Td /F1 9.8 Tf [(0.6)] TJ ET 0.267 0.267 0.267 rg 391.983 198.576 57.366 0.750 re f 391.983 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 186.906 Td /F1 9.8 Tf [(21)] TJ ET 0.267 0.267 0.267 rg 448.598 198.576 38.912 0.750 re f 448.598 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 186.906 Td /F1 9.8 Tf [(1.4)] TJ ET 0.267 0.267 0.267 rg 486.760 198.576 55.953 0.750 re f 486.760 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 186.906 Td /F1 9.8 Tf [(29)] TJ ET 0.267 0.267 0.267 rg 541.963 198.576 38.912 0.750 re f 541.963 176.598 0.750 22.728 re f 580.125 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 186.906 Td /F1 9.8 Tf [(2.0)] TJ ET 0.267 0.267 0.267 rg 26.625 176.598 81.984 0.750 re f 26.625 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 164.928 Td /F1 9.8 Tf [(Zidovska et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 152.548 Td /F4 8.7 Tf [(76)] TJ ET 0.271 0.267 0.267 rg BT 43.939 151.966 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 176.598 70.818 0.750 re f 107.859 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 164.928 Td /F1 9.8 Tf [(2007)] TJ ET 0.267 0.267 0.267 rg 177.927 176.598 80.585 0.750 re f 177.927 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 164.928 Td /F1 9.8 Tf [(Czech )] TJ ET BT 183.177 155.028 Td /F1 9.8 Tf [(Republic)] TJ ET 0.267 0.267 0.267 rg 257.761 176.598 47.042 0.750 re f 257.761 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 164.928 Td /F1 9.8 Tf [(411)] TJ ET 0.267 0.267 0.267 rg 304.053 176.598 57.366 0.750 re f 304.053 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 164.928 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 176.598 32.064 0.750 re f 360.669 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 164.928 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 176.598 57.366 0.750 re f 391.983 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 164.928 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 176.598 38.912 0.750 re f 448.598 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 164.928 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 176.598 55.953 0.750 re f 486.760 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 164.928 Td /F1 9.8 Tf [(12)] TJ ET 0.267 0.267 0.267 rg 541.963 176.598 38.912 0.750 re f 541.963 144.720 0.750 32.628 re f 580.125 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 164.928 Td /F1 9.8 Tf [(2.9)] TJ ET 0.267 0.267 0.267 rg 26.625 144.720 81.984 0.750 re f 26.625 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 133.050 Td /F1 9.8 Tf [(Van Duijn et )] TJ ET BT 31.875 120.088 Td /F1 9.8 Tf [(al)] TJ ET 0.267 0.267 0.267 rg BT 40.562 120.670 Td /F4 8.7 Tf [(77)] TJ ET 107.859 144.720 70.818 0.750 re f 107.859 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 133.050 Td /F1 9.8 Tf [(2008)] TJ ET 0.267 0.267 0.267 rg 177.927 144.720 80.585 0.750 re f 177.927 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 133.050 Td /F1 9.8 Tf [(Netherlands)] TJ ET 0.267 0.267 0.267 rg 257.761 144.720 47.042 0.750 re f 257.761 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 133.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 304.053 144.720 57.366 0.750 re f 304.053 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 133.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 144.720 32.064 0.750 re f 360.669 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 133.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 144.720 57.366 0.750 re f 391.983 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 133.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 144.720 38.912 0.750 re f 448.598 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 133.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 144.720 55.953 0.750 re f 486.760 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 133.050 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 541.963 144.720 38.912 0.750 re f 541.963 112.842 0.750 32.628 re f 580.125 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 133.050 Td /F1 9.8 Tf [(0.6)] TJ ET 0.267 0.267 0.267 rg 26.625 112.842 81.984 0.750 re f 26.625 80.964 81.984 0.750 re f 26.625 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 101.172 Td /F1 9.8 Tf [(Alonso et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 88.792 Td /F4 8.7 Tf [(78)] TJ ET 107.859 112.842 70.818 0.750 re f 107.859 80.964 70.818 0.750 re f 107.859 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 101.172 Td /F1 9.8 Tf [(2009)] TJ ET 0.267 0.267 0.267 rg 177.927 112.842 80.585 0.750 re f 177.927 80.964 80.585 0.750 re f 177.927 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 101.172 Td /F1 9.8 Tf [(Mexico)] TJ ET 0.267 0.267 0.267 rg 257.761 112.842 47.042 0.750 re f 257.761 80.964 47.042 0.750 re f 257.761 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 101.172 Td /F1 9.8 Tf [(691)] TJ ET 0.267 0.267 0.267 rg 304.053 112.842 57.366 0.750 re f 304.053 80.964 57.366 0.750 re f 304.053 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 101.172 Td /F1 9.8 Tf [(16)] TJ ET 0.267 0.267 0.267 rg 360.669 112.842 32.064 0.750 re f 360.669 80.964 32.064 0.750 re f 360.669 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 101.172 Td /F1 9.8 Tf [(2.3)] TJ ET 0.267 0.267 0.267 rg 391.983 112.842 57.366 0.750 re f 391.983 80.964 57.366 0.750 re f 391.983 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 101.172 Td /F1 9.8 Tf [(41)] TJ ET 0.267 0.267 0.267 rg 448.598 112.842 38.912 0.750 re f 448.598 80.964 38.912 0.750 re f 448.598 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 101.172 Td /F1 9.8 Tf [(5.9)] TJ ET 0.267 0.267 0.267 rg 486.760 112.842 55.953 0.750 re f 486.760 80.964 55.953 0.750 re f 486.760 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 101.172 Td /F1 9.8 Tf [(57)] TJ ET 0.267 0.267 0.267 rg 541.963 112.842 38.912 0.750 re f 541.963 80.964 38.912 0.750 re f 541.963 80.964 0.750 32.628 re f 580.125 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 101.172 Td /F1 9.8 Tf [(8.2)] TJ ET Q q 15.000 80.589 577.500 696.411 re W n 1.000 1.000 1.000 rg 26.250 80.589 555.000 696.411 re f 0.965 0.965 0.965 rg 27.000 745.737 81.234 31.263 re f 0.267 0.267 0.267 rg 26.625 745.362 0.750 31.638 re f 0.271 0.267 0.267 rg BT 31.500 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 108.234 745.737 70.068 31.263 re f 0.271 0.267 0.267 rg BT 112.734 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 178.302 745.737 79.835 31.263 re f 0.271 0.267 0.267 rg BT 182.802 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 258.136 745.737 46.292 31.263 re f 0.271 0.267 0.267 rg BT 262.636 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 304.428 745.737 56.616 31.263 re f 0.271 0.267 0.267 rg BT 308.928 764.645 Td /F4 9.8 Tf [(0 -10 )] TJ ET BT 308.928 749.201 Td /F4 9.8 Tf [(years)] TJ ET 0.965 0.965 0.965 rg 361.044 745.737 31.314 31.263 re f 0.271 0.267 0.267 rg BT 365.544 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 392.358 745.737 56.616 31.263 re f 0.271 0.267 0.267 rg BT 396.858 764.645 Td /F4 9.8 Tf [(11-20 )] TJ ET BT 396.858 749.201 Td /F4 9.8 Tf [(years)] TJ ET 0.965 0.965 0.965 rg 448.973 745.737 38.162 31.263 re f 0.271 0.267 0.267 rg BT 453.473 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 487.135 745.737 55.203 31.263 re f 0.271 0.267 0.267 rg BT 491.635 764.645 Td /F4 9.8 Tf [(Total )] TJ ET BT 491.635 749.201 Td /F4 9.8 Tf [(JHD)] TJ ET 0.965 0.965 0.965 rg 542.338 745.737 38.162 31.263 re f 0.267 0.267 0.267 rg 580.125 745.362 0.750 31.638 re f 0.271 0.267 0.267 rg BT 546.838 764.645 Td /F4 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 26.625 745.362 81.984 0.750 re f 26.625 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 31.875 730.630 Td /F1 9.8 Tf [(Atac et al)] TJ ET 0.267 0.267 0.267 rg BT 81.512 731.212 Td /F4 8.7 Tf [(60)] TJ ET 0.271 0.267 0.267 rg BT 93.576 730.630 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 745.362 70.818 0.750 re f 107.859 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 113.109 733.692 Td /F1 9.8 Tf [(1999)] TJ ET 0.267 0.267 0.267 rg 177.927 745.362 80.585 0.750 re f 177.927 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 183.177 733.692 Td /F1 9.8 Tf [(Turkey)] TJ ET 0.267 0.267 0.267 rg 257.761 745.362 47.042 0.750 re f 257.761 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 263.011 733.692 Td /F1 9.8 Tf [(27)] TJ ET 0.267 0.267 0.267 rg 304.053 745.362 57.366 0.750 re f 304.053 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 309.303 733.692 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 745.362 32.064 0.750 re f 360.669 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 365.919 733.692 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 745.362 57.366 0.750 re f 391.983 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 397.233 733.692 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 448.598 745.362 38.912 0.750 re f 448.598 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 453.848 733.692 Td /F1 9.8 Tf [(7.4)] TJ ET 0.267 0.267 0.267 rg 486.760 745.362 55.953 0.750 re f 486.760 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 492.010 733.692 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 541.963 745.362 38.912 0.750 re f 541.963 676.746 0.750 69.366 re f 580.125 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 547.213 733.692 Td /F1 9.8 Tf [(7.4)] TJ ET 0.267 0.267 0.267 rg 26.625 676.746 81.984 0.750 re f 26.625 644.868 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 665.076 Td /F1 9.8 Tf [(Faroud et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 652.696 Td /F4 8.7 Tf [(61)] TJ ET 0.271 0.267 0.267 rg BT 43.939 652.114 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 676.746 70.818 0.750 re f 107.859 644.868 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 665.076 Td /F1 9.8 Tf [(1999)] TJ ET 0.267 0.267 0.267 rg 177.927 676.746 80.585 0.750 re f 177.927 644.868 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 665.076 Td /F1 9.8 Tf [(USA)] TJ ET 0.267 0.267 0.267 rg 257.761 676.746 47.042 0.750 re f 257.761 644.868 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 665.076 Td /F1 9.8 Tf [(2068)] TJ ET 0.267 0.267 0.267 rg 304.053 676.746 57.366 0.750 re f 304.053 644.868 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 665.076 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 676.746 32.064 0.750 re f 360.669 644.868 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 665.076 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 676.746 57.366 0.750 re f 391.983 644.868 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 665.076 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 676.746 38.912 0.750 re f 448.598 644.868 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 665.076 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 676.746 55.953 0.750 re f 486.760 644.868 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 665.076 Td /F1 9.8 Tf [(94)] TJ ET 0.267 0.267 0.267 rg 541.963 676.746 38.912 0.750 re f 541.963 644.868 0.750 32.628 re f 580.125 644.868 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 665.076 Td /F1 9.8 Tf [(4.5)] TJ ET 0.267 0.267 0.267 rg 26.625 644.868 81.984 0.750 re f 26.625 622.890 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 630.136 Td /F1 9.8 Tf [(Louis et al)] TJ ET 0.267 0.267 0.267 rg BT 85.052 630.718 Td /F4 8.7 Tf [(62)] TJ ET 0.271 0.267 0.267 rg BT 97.116 630.136 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 644.868 70.818 0.750 re f 107.859 622.890 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 633.198 Td /F1 9.8 Tf [(1999)] TJ ET 0.267 0.267 0.267 rg 177.927 644.868 80.585 0.750 re f 177.927 622.890 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 633.198 Td /F1 9.8 Tf [(USA)] TJ ET 0.267 0.267 0.267 rg 257.761 644.868 47.042 0.750 re f 257.761 622.890 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 633.198 Td /F1 9.8 Tf [(43)] TJ ET 0.267 0.267 0.267 rg 304.053 644.868 57.366 0.750 re f 304.053 622.890 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 633.198 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 644.868 32.064 0.750 re f 360.669 622.890 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 633.198 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 644.868 57.366 0.750 re f 391.983 622.890 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 633.198 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 448.598 644.868 38.912 0.750 re f 448.598 622.890 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 633.198 Td /F1 9.8 Tf [(2.3)] TJ ET 0.267 0.267 0.267 rg 486.760 644.868 55.953 0.750 re f 486.760 622.890 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 633.198 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 541.963 644.868 38.912 0.750 re f 541.963 622.890 0.750 22.728 re f 580.125 622.890 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 633.198 Td /F1 9.8 Tf [(2.3)] TJ ET 0.267 0.267 0.267 rg 26.625 622.890 81.984 0.750 re f 26.625 600.912 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 608.158 Td /F1 9.8 Tf [(Lima et al)] TJ ET 0.267 0.267 0.267 rg BT 83.297 608.740 Td /F4 8.7 Tf [(63)] TJ ET 0.271 0.267 0.267 rg BT 95.361 608.158 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 622.890 70.818 0.750 re f 107.859 600.912 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 611.220 Td /F1 9.8 Tf [(2000)] TJ ET 0.267 0.267 0.267 rg 177.927 622.890 80.585 0.750 re f 177.927 600.912 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 611.220 Td /F1 9.8 Tf [(Brazil)] TJ ET 0.267 0.267 0.267 rg 257.761 622.890 47.042 0.750 re f 257.761 600.912 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 611.220 Td /F1 9.8 Tf [(30)] TJ ET 0.267 0.267 0.267 rg 304.053 622.890 57.366 0.750 re f 304.053 600.912 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 611.220 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 622.890 32.064 0.750 re f 360.669 600.912 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 611.220 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 622.890 57.366 0.750 re f 391.983 600.912 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 611.220 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 448.598 622.890 38.912 0.750 re f 448.598 600.912 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 611.220 Td /F1 9.8 Tf [(10)] TJ ET 0.267 0.267 0.267 rg 486.760 622.890 55.953 0.750 re f 486.760 600.912 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 611.220 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 541.963 622.890 38.912 0.750 re f 541.963 600.912 0.750 22.728 re f 580.125 600.912 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 611.220 Td /F1 9.8 Tf [(10)] TJ ET 0.267 0.267 0.267 rg 26.625 600.912 81.984 0.750 re f 26.625 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 589.242 Td /F1 9.8 Tf [(Raskin et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 576.862 Td /F4 8.7 Tf [(64)] TJ ET 0.271 0.267 0.267 rg BT 43.939 576.280 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 600.912 70.818 0.750 re f 107.859 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 589.242 Td /F1 9.8 Tf [(2000)] TJ ET 0.267 0.267 0.267 rg 177.927 600.912 80.585 0.750 re f 177.927 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 589.242 Td /F1 9.8 Tf [(Brazil)] TJ ET 0.267 0.267 0.267 rg 257.761 600.912 47.042 0.750 re f 257.761 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 589.242 Td /F1 9.8 Tf [(59)] TJ ET 0.267 0.267 0.267 rg 304.053 600.912 57.366 0.750 re f 304.053 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 589.242 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 360.669 600.912 32.064 0.750 re f 360.669 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 589.242 Td /F1 9.8 Tf [(5.1)] TJ ET 0.267 0.267 0.267 rg 391.983 600.912 57.366 0.750 re f 391.983 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 589.242 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 448.598 600.912 38.912 0.750 re f 448.598 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 589.242 Td /F1 9.8 Tf [(6.8)] TJ ET 0.267 0.267 0.267 rg 486.760 600.912 55.953 0.750 re f 486.760 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 589.242 Td /F1 9.8 Tf [(7)] TJ ET 0.267 0.267 0.267 rg 541.963 600.912 38.912 0.750 re f 541.963 569.034 0.750 32.628 re f 580.125 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 589.242 Td /F1 9.8 Tf [(11.9)] TJ ET 0.267 0.267 0.267 rg 26.625 569.034 81.984 0.750 re f 26.625 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 557.364 Td /F1 9.8 Tf [(Rasmussen )] TJ ET BT 31.875 544.402 Td /F1 9.8 Tf [(et al)] TJ ET 0.267 0.267 0.267 rg BT 53.481 544.984 Td /F4 8.7 Tf [(65)] TJ ET 0.271 0.267 0.267 rg BT 65.545 544.402 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 569.034 70.818 0.750 re f 107.859 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 557.364 Td /F1 9.8 Tf [(2000)] TJ ET 0.267 0.267 0.267 rg 177.927 569.034 80.585 0.750 re f 177.927 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 557.364 Td /F1 9.8 Tf [(Mexico)] TJ ET 0.267 0.267 0.267 rg 257.761 569.034 47.042 0.750 re f 257.761 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 557.364 Td /F1 9.8 Tf [(364)] TJ ET 0.267 0.267 0.267 rg 304.053 569.034 57.366 0.750 re f 304.053 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 557.364 Td /F1 9.8 Tf [(7)] TJ ET 0.267 0.267 0.267 rg 360.669 569.034 32.064 0.750 re f 360.669 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 557.364 Td /F1 9.8 Tf [(1.9)] TJ ET 0.267 0.267 0.267 rg 391.983 569.034 57.366 0.750 re f 391.983 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 557.364 Td /F1 9.8 Tf [(18)] TJ ET 0.267 0.267 0.267 rg 448.598 569.034 38.912 0.750 re f 448.598 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 557.364 Td /F1 9.8 Tf [(4.9)] TJ ET 0.267 0.267 0.267 rg 486.760 569.034 55.953 0.750 re f 486.760 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 557.364 Td /F1 9.8 Tf [(25)] TJ ET 0.267 0.267 0.267 rg 541.963 569.034 38.912 0.750 re f 541.963 537.156 0.750 32.628 re f 580.125 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 557.364 Td /F1 9.8 Tf [(6.9)] TJ ET 0.267 0.267 0.267 rg 26.625 537.156 81.984 0.750 re f 26.625 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 525.486 Td /F1 9.8 Tf [(Almqvist et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 513.106 Td /F4 8.7 Tf [(66)] TJ ET 0.271 0.267 0.267 rg BT 43.939 512.524 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 537.156 70.818 0.750 re f 107.859 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 525.486 Td /F1 9.8 Tf [(2001)] TJ ET 0.267 0.267 0.267 rg 177.927 537.156 80.585 0.750 re f 177.927 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 525.486 Td /F1 9.8 Tf [(Canada)] TJ ET 0.267 0.267 0.267 rg 257.761 537.156 47.042 0.750 re f 257.761 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 525.486 Td /F1 9.8 Tf [(102)] TJ ET 0.267 0.267 0.267 rg 304.053 537.156 57.366 0.750 re f 304.053 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 525.486 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 537.156 32.064 0.750 re f 360.669 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 525.486 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 537.156 57.366 0.750 re f 391.983 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 525.486 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 448.598 537.156 38.912 0.750 re f 448.598 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 525.486 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 486.760 537.156 55.953 0.750 re f 486.760 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 525.486 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 541.963 537.156 38.912 0.750 re f 541.963 505.278 0.750 32.628 re f 580.125 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 525.486 Td /F1 9.8 Tf [(2.0)] TJ ET 0.267 0.267 0.267 rg 26.625 505.278 81.984 0.750 re f 26.625 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 493.608 Td /F1 9.8 Tf [(Murgod et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 481.228 Td /F4 8.7 Tf [(68)] TJ ET 0.271 0.267 0.267 rg BT 43.939 480.646 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 505.278 70.818 0.750 re f 107.859 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 493.608 Td /F1 9.8 Tf [(2001)] TJ ET 0.267 0.267 0.267 rg 177.927 505.278 80.585 0.750 re f 177.927 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 493.608 Td /F1 9.8 Tf [(India)] TJ ET 0.267 0.267 0.267 rg 257.761 505.278 47.042 0.750 re f 257.761 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 493.608 Td /F1 9.8 Tf [(26)] TJ ET 0.267 0.267 0.267 rg 304.053 505.278 57.366 0.750 re f 304.053 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 493.608 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 505.278 32.064 0.750 re f 360.669 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 493.608 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 505.278 57.366 0.750 re f 391.983 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 493.608 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 505.278 38.912 0.750 re f 448.598 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 493.608 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 505.278 55.953 0.750 re f 486.760 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 493.608 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 541.963 505.278 38.912 0.750 re f 541.963 473.400 0.750 32.628 re f 580.125 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 493.608 Td /F1 9.8 Tf [(15.4)] TJ ET 0.267 0.267 0.267 rg 26.625 473.400 81.984 0.750 re f 26.625 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 461.730 Td /F1 9.8 Tf [(Maat Kievit et )] TJ ET BT 31.875 448.768 Td /F1 9.8 Tf [(al)] TJ ET 0.267 0.267 0.267 rg BT 40.562 449.350 Td /F4 8.7 Tf [(68)] TJ ET 0.271 0.267 0.267 rg BT 52.626 448.768 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 473.400 70.818 0.750 re f 107.859 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 461.730 Td /F1 9.8 Tf [(2002)] TJ ET 0.267 0.267 0.267 rg 177.927 473.400 80.585 0.750 re f 177.927 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 461.730 Td /F1 9.8 Tf [(Netherlands)] TJ ET 0.267 0.267 0.267 rg 257.761 473.400 47.042 0.750 re f 257.761 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 461.730 Td /F1 9.8 Tf [(755)] TJ ET 0.267 0.267 0.267 rg 304.053 473.400 57.366 0.750 re f 304.053 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 461.730 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 473.400 32.064 0.750 re f 360.669 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 461.730 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 473.400 57.366 0.750 re f 391.983 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 461.730 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 473.400 38.912 0.750 re f 448.598 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 461.730 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 473.400 55.953 0.750 re f 486.760 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 461.730 Td /F1 9.8 Tf [(18)] TJ ET 0.267 0.267 0.267 rg 541.963 473.400 38.912 0.750 re f 541.963 441.522 0.750 32.628 re f 580.125 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 461.730 Td /F1 9.8 Tf [(3.0)] TJ ET 0.267 0.267 0.267 rg 26.625 441.522 81.984 0.750 re f 26.625 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 31.875 429.852 Td /F1 9.8 Tf [(Akbas )] TJ ET BT 31.875 419.952 Td /F1 9.8 Tf [(Erginel-)] TJ ET BT 31.875 406.990 Td /F1 9.8 Tf [(Unaltuna)] TJ ET 0.267 0.267 0.267 rg BT 76.042 407.572 Td /F4 8.7 Tf [(69)] TJ ET 0.271 0.267 0.267 rg BT 88.107 406.990 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 441.522 70.818 0.750 re f 107.859 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 113.109 429.852 Td /F1 9.8 Tf [(2003)] TJ ET 0.267 0.267 0.267 rg 177.927 441.522 80.585 0.750 re f 177.927 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 183.177 429.852 Td /F1 9.8 Tf [(Turkey)] TJ ET 0.267 0.267 0.267 rg 257.761 441.522 47.042 0.750 re f 257.761 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 263.011 429.852 Td /F1 9.8 Tf [(127)] TJ ET 0.267 0.267 0.267 rg 304.053 441.522 57.366 0.750 re f 304.053 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 309.303 429.852 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 360.669 441.522 32.064 0.750 re f 360.669 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 365.919 429.852 Td /F1 9.8 Tf [(0.8)] TJ ET 0.267 0.267 0.267 rg 391.983 441.522 57.366 0.750 re f 391.983 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 397.233 429.852 Td /F1 9.8 Tf [(7)] TJ ET 0.267 0.267 0.267 rg 448.598 441.522 38.912 0.750 re f 448.598 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 453.848 429.852 Td /F1 9.8 Tf [(5.5)] TJ ET 0.267 0.267 0.267 rg 486.760 441.522 55.953 0.750 re f 486.760 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 492.010 429.852 Td /F1 9.8 Tf [(8)] TJ ET 0.267 0.267 0.267 rg 541.963 441.522 38.912 0.750 re f 541.963 399.744 0.750 42.528 re f 580.125 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 547.213 429.852 Td /F1 9.8 Tf [(6.3)] TJ ET 0.267 0.267 0.267 rg 26.625 399.744 81.984 0.750 re f 26.625 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 388.074 Td /F1 9.8 Tf [(Creighton et )] TJ ET BT 31.875 375.112 Td /F1 9.8 Tf [(al)] TJ ET 0.267 0.267 0.267 rg BT 40.562 375.694 Td /F4 8.7 Tf [(71)] TJ ET 107.859 399.744 70.818 0.750 re f 107.859 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 388.074 Td /F1 9.8 Tf [(2003)] TJ ET 0.267 0.267 0.267 rg 177.927 399.744 80.585 0.750 re f 177.927 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 388.074 Td /F1 9.8 Tf [(Canada)] TJ ET 0.267 0.267 0.267 rg 257.761 399.744 47.042 0.750 re f 257.761 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 388.074 Td /F1 9.8 Tf [(282)] TJ ET 0.267 0.267 0.267 rg 304.053 399.744 57.366 0.750 re f 304.053 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 388.074 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 399.744 32.064 0.750 re f 360.669 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 388.074 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 399.744 57.366 0.750 re f 391.983 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 388.074 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 399.744 38.912 0.750 re f 448.598 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 388.074 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 399.744 55.953 0.750 re f 486.760 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 388.074 Td /F1 9.8 Tf [(5)] TJ ET 0.267 0.267 0.267 rg 541.963 399.744 38.912 0.750 re f 541.963 367.866 0.750 32.628 re f 580.125 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 388.074 Td /F1 9.8 Tf [(1.8)] TJ ET 0.267 0.267 0.267 rg 26.625 367.866 81.984 0.750 re f 26.625 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 31.875 356.196 Td /F1 9.8 Tf [(do Como )] TJ ET BT 31.875 346.296 Td /F1 9.8 Tf [(Costa)] TJ ET BT 31.875 333.334 Td /F1 9.8 Tf [(et al)] TJ ET 0.267 0.267 0.267 rg BT 53.481 333.916 Td /F4 8.7 Tf [(72)] TJ ET 107.859 367.866 70.818 0.750 re f 107.859 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 113.109 356.196 Td /F1 9.8 Tf [(2003)] TJ ET 0.267 0.267 0.267 rg 177.927 367.866 80.585 0.750 re f 177.927 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 183.177 356.196 Td /F1 9.8 Tf [(Portugaul)] TJ ET 0.267 0.267 0.267 rg 257.761 367.866 47.042 0.750 re f 257.761 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 263.011 356.196 Td /F1 9.8 Tf [(120)] TJ ET 0.267 0.267 0.267 rg 304.053 367.866 57.366 0.750 re f 304.053 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 309.303 356.196 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 360.669 367.866 32.064 0.750 re f 360.669 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 365.919 356.196 Td /F1 9.8 Tf [(2.5)] TJ ET 0.267 0.267 0.267 rg 391.983 367.866 57.366 0.750 re f 391.983 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 397.233 356.196 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 448.598 367.866 38.912 0.750 re f 448.598 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 453.848 356.196 Td /F1 9.8 Tf [(0.8)] TJ ET 0.267 0.267 0.267 rg 486.760 367.866 55.953 0.750 re f 486.760 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 492.010 356.196 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 541.963 367.866 38.912 0.750 re f 541.963 326.088 0.750 42.528 re f 580.125 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 547.213 356.196 Td /F1 9.8 Tf [(3.3)] TJ ET 0.267 0.267 0.267 rg 26.625 326.088 81.984 0.750 re f 26.625 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 314.418 Td /F1 9.8 Tf [(Cannella et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 302.038 Td /F4 8.7 Tf [(73)] TJ ET 107.859 326.088 70.818 0.750 re f 107.859 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 314.418 Td /F1 9.8 Tf [(2004)] TJ ET 0.267 0.267 0.267 rg 177.927 326.088 80.585 0.750 re f 177.927 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 314.418 Td /F1 9.8 Tf [(Italy)] TJ ET 0.267 0.267 0.267 rg 257.761 326.088 47.042 0.750 re f 257.761 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 314.418 Td /F1 9.8 Tf [(524)] TJ ET 0.267 0.267 0.267 rg 304.053 326.088 57.366 0.750 re f 304.053 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 314.418 Td /F1 9.8 Tf [(5)] TJ ET 0.267 0.267 0.267 rg 360.669 326.088 32.064 0.750 re f 360.669 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 314.418 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 391.983 326.088 57.366 0.750 re f 391.983 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 314.418 Td /F1 9.8 Tf [(52)] TJ ET 0.267 0.267 0.267 rg 448.598 326.088 38.912 0.750 re f 448.598 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 314.418 Td /F1 9.8 Tf [(9.9)] TJ ET 0.267 0.267 0.267 rg 486.760 326.088 55.953 0.750 re f 486.760 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 314.418 Td /F1 9.8 Tf [(57)] TJ ET 0.267 0.267 0.267 rg 541.963 326.088 38.912 0.750 re f 541.963 294.210 0.750 32.628 re f 580.125 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 314.418 Td /F1 9.8 Tf [(10.9)] TJ ET 0.267 0.267 0.267 rg 26.625 294.210 81.984 0.750 re f 26.625 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 282.540 Td /F1 9.8 Tf [(Wexler et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 270.160 Td /F4 8.7 Tf [(10)] TJ ET 0.271 0.267 0.267 rg BT 43.939 269.578 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 294.210 70.818 0.750 re f 107.859 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 282.540 Td /F1 9.8 Tf [(2004)] TJ ET 0.267 0.267 0.267 rg 177.927 294.210 80.585 0.750 re f 177.927 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 282.540 Td /F1 9.8 Tf [(Venezueala)] TJ ET 0.267 0.267 0.267 rg 257.761 294.210 47.042 0.750 re f 257.761 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 282.540 Td /F1 9.8 Tf [(443)] TJ ET 0.267 0.267 0.267 rg 304.053 294.210 57.366 0.750 re f 304.053 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 282.540 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 294.210 32.064 0.750 re f 360.669 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 282.540 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 294.210 57.366 0.750 re f 391.983 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 282.540 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 294.210 38.912 0.750 re f 448.598 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 282.540 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 294.210 55.953 0.750 re f 486.760 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 282.540 Td /F1 9.8 Tf [(40)] TJ ET 0.267 0.267 0.267 rg 541.963 294.210 38.912 0.750 re f 541.963 262.332 0.750 32.628 re f 580.125 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 282.540 Td /F1 9.8 Tf [(9.0)] TJ ET 0.267 0.267 0.267 rg 26.625 262.332 81.984 0.750 re f 26.625 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 250.662 Td /F1 9.8 Tf [(Ramos-Aroyo )] TJ ET BT 31.875 237.700 Td /F1 9.8 Tf [(et al)] TJ ET 0.267 0.267 0.267 rg BT 53.481 238.282 Td /F4 8.7 Tf [(74)] TJ ET 0.271 0.267 0.267 rg BT 65.545 237.700 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 262.332 70.818 0.750 re f 107.859 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 250.662 Td /F1 9.8 Tf [(2005)] TJ ET 0.267 0.267 0.267 rg 177.927 262.332 80.585 0.750 re f 177.927 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 250.662 Td /F1 9.8 Tf [(Spain)] TJ ET 0.267 0.267 0.267 rg 257.761 262.332 47.042 0.750 re f 257.761 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 250.662 Td /F1 9.8 Tf [(112)] TJ ET 0.267 0.267 0.267 rg 304.053 262.332 57.366 0.750 re f 304.053 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 250.662 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 262.332 32.064 0.750 re f 360.669 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 250.662 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 262.332 57.366 0.750 re f 391.983 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 250.662 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 262.332 38.912 0.750 re f 448.598 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 250.662 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 262.332 55.953 0.750 re f 486.760 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 250.662 Td /F1 9.8 Tf [(7)] TJ ET 0.267 0.267 0.267 rg 541.963 262.332 38.912 0.750 re f 541.963 230.454 0.750 32.628 re f 580.125 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 250.662 Td /F1 9.8 Tf [(6.3)] TJ ET 0.267 0.267 0.267 rg 26.625 230.454 81.984 0.750 re f 26.625 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 218.784 Td /F1 9.8 Tf [(Ruocco et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 206.404 Td /F4 8.7 Tf [(74)] TJ ET 0.271 0.267 0.267 rg BT 43.939 205.822 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 230.454 70.818 0.750 re f 107.859 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 218.784 Td /F1 9.8 Tf [(2006)] TJ ET 0.267 0.267 0.267 rg 177.927 230.454 80.585 0.750 re f 177.927 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 218.784 Td /F1 9.8 Tf [(Brazil)] TJ ET 0.267 0.267 0.267 rg 257.761 230.454 47.042 0.750 re f 257.761 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 218.784 Td /F1 9.8 Tf [(50)] TJ ET 0.267 0.267 0.267 rg 304.053 230.454 57.366 0.750 re f 304.053 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 218.784 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 360.669 230.454 32.064 0.750 re f 360.669 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 218.784 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 391.983 230.454 57.366 0.750 re f 391.983 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 218.784 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 448.598 230.454 38.912 0.750 re f 448.598 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 218.784 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 486.760 230.454 55.953 0.750 re f 486.760 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 218.784 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 541.963 230.454 38.912 0.750 re f 541.963 198.576 0.750 32.628 re f 580.125 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 218.784 Td /F1 9.8 Tf [(8.0)] TJ ET 0.267 0.267 0.267 rg 26.625 198.576 81.984 0.750 re f 26.625 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 183.844 Td /F1 9.8 Tf [(Ribai et al)] TJ ET 0.267 0.267 0.267 rg BT 84.047 184.426 Td /F4 8.7 Tf [(6)] TJ ET 0.271 0.267 0.267 rg BT 90.079 183.844 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 198.576 70.818 0.750 re f 107.859 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 186.906 Td /F1 9.8 Tf [(2007)] TJ ET 0.267 0.267 0.267 rg 177.927 198.576 80.585 0.750 re f 177.927 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 186.906 Td /F1 9.8 Tf [(France)] TJ ET 0.267 0.267 0.267 rg 257.761 198.576 47.042 0.750 re f 257.761 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 186.906 Td /F1 9.8 Tf [(1453)] TJ ET 0.267 0.267 0.267 rg 304.053 198.576 57.366 0.750 re f 304.053 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 186.906 Td /F1 9.8 Tf [(8)] TJ ET 0.267 0.267 0.267 rg 360.669 198.576 32.064 0.750 re f 360.669 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 186.906 Td /F1 9.8 Tf [(0.6)] TJ ET 0.267 0.267 0.267 rg 391.983 198.576 57.366 0.750 re f 391.983 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 186.906 Td /F1 9.8 Tf [(21)] TJ ET 0.267 0.267 0.267 rg 448.598 198.576 38.912 0.750 re f 448.598 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 186.906 Td /F1 9.8 Tf [(1.4)] TJ ET 0.267 0.267 0.267 rg 486.760 198.576 55.953 0.750 re f 486.760 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 186.906 Td /F1 9.8 Tf [(29)] TJ ET 0.267 0.267 0.267 rg 541.963 198.576 38.912 0.750 re f 541.963 176.598 0.750 22.728 re f 580.125 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 186.906 Td /F1 9.8 Tf [(2.0)] TJ ET 0.267 0.267 0.267 rg 26.625 176.598 81.984 0.750 re f 26.625 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 164.928 Td /F1 9.8 Tf [(Zidovska et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 152.548 Td /F4 8.7 Tf [(76)] TJ ET 0.271 0.267 0.267 rg BT 43.939 151.966 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 176.598 70.818 0.750 re f 107.859 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 164.928 Td /F1 9.8 Tf [(2007)] TJ ET 0.267 0.267 0.267 rg 177.927 176.598 80.585 0.750 re f 177.927 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 164.928 Td /F1 9.8 Tf [(Czech )] TJ ET BT 183.177 155.028 Td /F1 9.8 Tf [(Republic)] TJ ET 0.267 0.267 0.267 rg 257.761 176.598 47.042 0.750 re f 257.761 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 164.928 Td /F1 9.8 Tf [(411)] TJ ET 0.267 0.267 0.267 rg 304.053 176.598 57.366 0.750 re f 304.053 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 164.928 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 176.598 32.064 0.750 re f 360.669 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 164.928 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 176.598 57.366 0.750 re f 391.983 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 164.928 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 176.598 38.912 0.750 re f 448.598 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 164.928 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 176.598 55.953 0.750 re f 486.760 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 164.928 Td /F1 9.8 Tf [(12)] TJ ET 0.267 0.267 0.267 rg 541.963 176.598 38.912 0.750 re f 541.963 144.720 0.750 32.628 re f 580.125 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 164.928 Td /F1 9.8 Tf [(2.9)] TJ ET 0.267 0.267 0.267 rg 26.625 144.720 81.984 0.750 re f 26.625 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 133.050 Td /F1 9.8 Tf [(Van Duijn et )] TJ ET BT 31.875 120.088 Td /F1 9.8 Tf [(al)] TJ ET 0.267 0.267 0.267 rg BT 40.562 120.670 Td /F4 8.7 Tf [(77)] TJ ET 107.859 144.720 70.818 0.750 re f 107.859 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 133.050 Td /F1 9.8 Tf [(2008)] TJ ET 0.267 0.267 0.267 rg 177.927 144.720 80.585 0.750 re f 177.927 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 133.050 Td /F1 9.8 Tf [(Netherlands)] TJ ET 0.267 0.267 0.267 rg 257.761 144.720 47.042 0.750 re f 257.761 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 133.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 304.053 144.720 57.366 0.750 re f 304.053 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 133.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 144.720 32.064 0.750 re f 360.669 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 133.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 144.720 57.366 0.750 re f 391.983 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 133.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 144.720 38.912 0.750 re f 448.598 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 133.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 144.720 55.953 0.750 re f 486.760 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 133.050 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 541.963 144.720 38.912 0.750 re f 541.963 112.842 0.750 32.628 re f 580.125 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 133.050 Td /F1 9.8 Tf [(0.6)] TJ ET 0.267 0.267 0.267 rg 26.625 112.842 81.984 0.750 re f 26.625 80.964 81.984 0.750 re f 26.625 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 101.172 Td /F1 9.8 Tf [(Alonso et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 88.792 Td /F4 8.7 Tf [(78)] TJ ET 107.859 112.842 70.818 0.750 re f 107.859 80.964 70.818 0.750 re f 107.859 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 101.172 Td /F1 9.8 Tf [(2009)] TJ ET 0.267 0.267 0.267 rg 177.927 112.842 80.585 0.750 re f 177.927 80.964 80.585 0.750 re f 177.927 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 101.172 Td /F1 9.8 Tf [(Mexico)] TJ ET 0.267 0.267 0.267 rg 257.761 112.842 47.042 0.750 re f 257.761 80.964 47.042 0.750 re f 257.761 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 101.172 Td /F1 9.8 Tf [(691)] TJ ET 0.267 0.267 0.267 rg 304.053 112.842 57.366 0.750 re f 304.053 80.964 57.366 0.750 re f 304.053 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 101.172 Td /F1 9.8 Tf [(16)] TJ ET 0.267 0.267 0.267 rg 360.669 112.842 32.064 0.750 re f 360.669 80.964 32.064 0.750 re f 360.669 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 101.172 Td /F1 9.8 Tf [(2.3)] TJ ET 0.267 0.267 0.267 rg 391.983 112.842 57.366 0.750 re f 391.983 80.964 57.366 0.750 re f 391.983 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 101.172 Td /F1 9.8 Tf [(41)] TJ ET 0.267 0.267 0.267 rg 448.598 112.842 38.912 0.750 re f 448.598 80.964 38.912 0.750 re f 448.598 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 101.172 Td /F1 9.8 Tf [(5.9)] TJ ET 0.267 0.267 0.267 rg 486.760 112.842 55.953 0.750 re f 486.760 80.964 55.953 0.750 re f 486.760 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 101.172 Td /F1 9.8 Tf [(57)] TJ ET 0.267 0.267 0.267 rg 541.963 112.842 38.912 0.750 re f 541.963 80.964 38.912 0.750 re f 541.963 80.964 0.750 32.628 re f 580.125 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 101.172 Td /F1 9.8 Tf [(8.2)] TJ ET Q q 15.000 80.589 577.500 696.411 re W n 1.000 1.000 1.000 rg 26.250 80.589 555.000 696.411 re f 0.965 0.965 0.965 rg 27.000 745.737 81.234 31.263 re f 0.267 0.267 0.267 rg 26.625 745.362 0.750 31.638 re f 0.271 0.267 0.267 rg BT 31.500 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 108.234 745.737 70.068 31.263 re f 0.271 0.267 0.267 rg BT 112.734 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 178.302 745.737 79.835 31.263 re f 0.271 0.267 0.267 rg BT 182.802 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 258.136 745.737 46.292 31.263 re f 0.271 0.267 0.267 rg BT 262.636 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 304.428 745.737 56.616 31.263 re f 0.271 0.267 0.267 rg BT 308.928 764.645 Td /F4 9.8 Tf [(0 -10 )] TJ ET BT 308.928 749.201 Td /F4 9.8 Tf [(years)] TJ ET 0.965 0.965 0.965 rg 361.044 745.737 31.314 31.263 re f 0.271 0.267 0.267 rg BT 365.544 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 392.358 745.737 56.616 31.263 re f 0.271 0.267 0.267 rg BT 396.858 764.645 Td /F4 9.8 Tf [(11-20 )] TJ ET BT 396.858 749.201 Td /F4 9.8 Tf [(years)] TJ ET 0.965 0.965 0.965 rg 448.973 745.737 38.162 31.263 re f 0.271 0.267 0.267 rg BT 453.473 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 487.135 745.737 55.203 31.263 re f 0.271 0.267 0.267 rg BT 491.635 764.645 Td /F4 9.8 Tf [(Total )] TJ ET BT 491.635 749.201 Td /F4 9.8 Tf [(JHD)] TJ ET 0.965 0.965 0.965 rg 542.338 745.737 38.162 31.263 re f 0.267 0.267 0.267 rg 580.125 745.362 0.750 31.638 re f 0.271 0.267 0.267 rg BT 546.838 764.645 Td /F4 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 26.625 745.362 81.984 0.750 re f 26.625 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 31.875 730.630 Td /F1 9.8 Tf [(Atac et al)] TJ ET 0.267 0.267 0.267 rg BT 81.512 731.212 Td /F4 8.7 Tf [(60)] TJ ET 0.271 0.267 0.267 rg BT 93.576 730.630 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 745.362 70.818 0.750 re f 107.859 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 113.109 733.692 Td /F1 9.8 Tf [(1999)] TJ ET 0.267 0.267 0.267 rg 177.927 745.362 80.585 0.750 re f 177.927 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 183.177 733.692 Td /F1 9.8 Tf [(Turkey)] TJ ET 0.267 0.267 0.267 rg 257.761 745.362 47.042 0.750 re f 257.761 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 263.011 733.692 Td /F1 9.8 Tf [(27)] TJ ET 0.267 0.267 0.267 rg 304.053 745.362 57.366 0.750 re f 304.053 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 309.303 733.692 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 745.362 32.064 0.750 re f 360.669 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 365.919 733.692 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 745.362 57.366 0.750 re f 391.983 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 397.233 733.692 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 448.598 745.362 38.912 0.750 re f 448.598 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 453.848 733.692 Td /F1 9.8 Tf [(7.4)] TJ ET 0.267 0.267 0.267 rg 486.760 745.362 55.953 0.750 re f 486.760 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 492.010 733.692 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 541.963 745.362 38.912 0.750 re f 541.963 676.746 0.750 69.366 re f 580.125 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 547.213 733.692 Td /F1 9.8 Tf [(7.4)] TJ ET 0.267 0.267 0.267 rg 26.625 676.746 81.984 0.750 re f 26.625 644.868 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 665.076 Td /F1 9.8 Tf [(Faroud et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 652.696 Td /F4 8.7 Tf [(61)] TJ ET 0.271 0.267 0.267 rg BT 43.939 652.114 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 676.746 70.818 0.750 re f 107.859 644.868 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 665.076 Td /F1 9.8 Tf [(1999)] TJ ET 0.267 0.267 0.267 rg 177.927 676.746 80.585 0.750 re f 177.927 644.868 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 665.076 Td /F1 9.8 Tf [(USA)] TJ ET 0.267 0.267 0.267 rg 257.761 676.746 47.042 0.750 re f 257.761 644.868 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 665.076 Td /F1 9.8 Tf [(2068)] TJ ET 0.267 0.267 0.267 rg 304.053 676.746 57.366 0.750 re f 304.053 644.868 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 665.076 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 676.746 32.064 0.750 re f 360.669 644.868 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 665.076 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 676.746 57.366 0.750 re f 391.983 644.868 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 665.076 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 676.746 38.912 0.750 re f 448.598 644.868 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 665.076 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 676.746 55.953 0.750 re f 486.760 644.868 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 665.076 Td /F1 9.8 Tf [(94)] TJ ET 0.267 0.267 0.267 rg 541.963 676.746 38.912 0.750 re f 541.963 644.868 0.750 32.628 re f 580.125 644.868 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 665.076 Td /F1 9.8 Tf [(4.5)] TJ ET 0.267 0.267 0.267 rg 26.625 644.868 81.984 0.750 re f 26.625 622.890 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 630.136 Td /F1 9.8 Tf [(Louis et al)] TJ ET 0.267 0.267 0.267 rg BT 85.052 630.718 Td /F4 8.7 Tf [(62)] TJ ET 0.271 0.267 0.267 rg BT 97.116 630.136 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 644.868 70.818 0.750 re f 107.859 622.890 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 633.198 Td /F1 9.8 Tf [(1999)] TJ ET 0.267 0.267 0.267 rg 177.927 644.868 80.585 0.750 re f 177.927 622.890 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 633.198 Td /F1 9.8 Tf [(USA)] TJ ET 0.267 0.267 0.267 rg 257.761 644.868 47.042 0.750 re f 257.761 622.890 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 633.198 Td /F1 9.8 Tf [(43)] TJ ET 0.267 0.267 0.267 rg 304.053 644.868 57.366 0.750 re f 304.053 622.890 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 633.198 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 644.868 32.064 0.750 re f 360.669 622.890 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 633.198 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 644.868 57.366 0.750 re f 391.983 622.890 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 633.198 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 448.598 644.868 38.912 0.750 re f 448.598 622.890 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 633.198 Td /F1 9.8 Tf [(2.3)] TJ ET 0.267 0.267 0.267 rg 486.760 644.868 55.953 0.750 re f 486.760 622.890 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 633.198 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 541.963 644.868 38.912 0.750 re f 541.963 622.890 0.750 22.728 re f 580.125 622.890 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 633.198 Td /F1 9.8 Tf [(2.3)] TJ ET 0.267 0.267 0.267 rg 26.625 622.890 81.984 0.750 re f 26.625 600.912 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 608.158 Td /F1 9.8 Tf [(Lima et al)] TJ ET 0.267 0.267 0.267 rg BT 83.297 608.740 Td /F4 8.7 Tf [(63)] TJ ET 0.271 0.267 0.267 rg BT 95.361 608.158 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 622.890 70.818 0.750 re f 107.859 600.912 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 611.220 Td /F1 9.8 Tf [(2000)] TJ ET 0.267 0.267 0.267 rg 177.927 622.890 80.585 0.750 re f 177.927 600.912 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 611.220 Td /F1 9.8 Tf [(Brazil)] TJ ET 0.267 0.267 0.267 rg 257.761 622.890 47.042 0.750 re f 257.761 600.912 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 611.220 Td /F1 9.8 Tf [(30)] TJ ET 0.267 0.267 0.267 rg 304.053 622.890 57.366 0.750 re f 304.053 600.912 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 611.220 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 622.890 32.064 0.750 re f 360.669 600.912 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 611.220 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 622.890 57.366 0.750 re f 391.983 600.912 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 611.220 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 448.598 622.890 38.912 0.750 re f 448.598 600.912 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 611.220 Td /F1 9.8 Tf [(10)] TJ ET 0.267 0.267 0.267 rg 486.760 622.890 55.953 0.750 re f 486.760 600.912 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 611.220 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 541.963 622.890 38.912 0.750 re f 541.963 600.912 0.750 22.728 re f 580.125 600.912 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 611.220 Td /F1 9.8 Tf [(10)] TJ ET 0.267 0.267 0.267 rg 26.625 600.912 81.984 0.750 re f 26.625 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 589.242 Td /F1 9.8 Tf [(Raskin et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 576.862 Td /F4 8.7 Tf [(64)] TJ ET 0.271 0.267 0.267 rg BT 43.939 576.280 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 600.912 70.818 0.750 re f 107.859 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 589.242 Td /F1 9.8 Tf [(2000)] TJ ET 0.267 0.267 0.267 rg 177.927 600.912 80.585 0.750 re f 177.927 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 589.242 Td /F1 9.8 Tf [(Brazil)] TJ ET 0.267 0.267 0.267 rg 257.761 600.912 47.042 0.750 re f 257.761 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 589.242 Td /F1 9.8 Tf [(59)] TJ ET 0.267 0.267 0.267 rg 304.053 600.912 57.366 0.750 re f 304.053 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 589.242 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 360.669 600.912 32.064 0.750 re f 360.669 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 589.242 Td /F1 9.8 Tf [(5.1)] TJ ET 0.267 0.267 0.267 rg 391.983 600.912 57.366 0.750 re f 391.983 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 589.242 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 448.598 600.912 38.912 0.750 re f 448.598 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 589.242 Td /F1 9.8 Tf [(6.8)] TJ ET 0.267 0.267 0.267 rg 486.760 600.912 55.953 0.750 re f 486.760 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 589.242 Td /F1 9.8 Tf [(7)] TJ ET 0.267 0.267 0.267 rg 541.963 600.912 38.912 0.750 re f 541.963 569.034 0.750 32.628 re f 580.125 569.034 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 589.242 Td /F1 9.8 Tf [(11.9)] TJ ET 0.267 0.267 0.267 rg 26.625 569.034 81.984 0.750 re f 26.625 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 557.364 Td /F1 9.8 Tf [(Rasmussen )] TJ ET BT 31.875 544.402 Td /F1 9.8 Tf [(et al)] TJ ET 0.267 0.267 0.267 rg BT 53.481 544.984 Td /F4 8.7 Tf [(65)] TJ ET 0.271 0.267 0.267 rg BT 65.545 544.402 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 569.034 70.818 0.750 re f 107.859 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 557.364 Td /F1 9.8 Tf [(2000)] TJ ET 0.267 0.267 0.267 rg 177.927 569.034 80.585 0.750 re f 177.927 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 557.364 Td /F1 9.8 Tf [(Mexico)] TJ ET 0.267 0.267 0.267 rg 257.761 569.034 47.042 0.750 re f 257.761 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 557.364 Td /F1 9.8 Tf [(364)] TJ ET 0.267 0.267 0.267 rg 304.053 569.034 57.366 0.750 re f 304.053 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 557.364 Td /F1 9.8 Tf [(7)] TJ ET 0.267 0.267 0.267 rg 360.669 569.034 32.064 0.750 re f 360.669 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 557.364 Td /F1 9.8 Tf [(1.9)] TJ ET 0.267 0.267 0.267 rg 391.983 569.034 57.366 0.750 re f 391.983 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 557.364 Td /F1 9.8 Tf [(18)] TJ ET 0.267 0.267 0.267 rg 448.598 569.034 38.912 0.750 re f 448.598 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 557.364 Td /F1 9.8 Tf [(4.9)] TJ ET 0.267 0.267 0.267 rg 486.760 569.034 55.953 0.750 re f 486.760 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 557.364 Td /F1 9.8 Tf [(25)] TJ ET 0.267 0.267 0.267 rg 541.963 569.034 38.912 0.750 re f 541.963 537.156 0.750 32.628 re f 580.125 537.156 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 557.364 Td /F1 9.8 Tf [(6.9)] TJ ET 0.267 0.267 0.267 rg 26.625 537.156 81.984 0.750 re f 26.625 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 525.486 Td /F1 9.8 Tf [(Almqvist et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 513.106 Td /F4 8.7 Tf [(66)] TJ ET 0.271 0.267 0.267 rg BT 43.939 512.524 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 537.156 70.818 0.750 re f 107.859 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 525.486 Td /F1 9.8 Tf [(2001)] TJ ET 0.267 0.267 0.267 rg 177.927 537.156 80.585 0.750 re f 177.927 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 525.486 Td /F1 9.8 Tf [(Canada)] TJ ET 0.267 0.267 0.267 rg 257.761 537.156 47.042 0.750 re f 257.761 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 525.486 Td /F1 9.8 Tf [(102)] TJ ET 0.267 0.267 0.267 rg 304.053 537.156 57.366 0.750 re f 304.053 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 525.486 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 360.669 537.156 32.064 0.750 re f 360.669 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 525.486 Td /F1 9.8 Tf [(0)] TJ ET 0.267 0.267 0.267 rg 391.983 537.156 57.366 0.750 re f 391.983 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 525.486 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 448.598 537.156 38.912 0.750 re f 448.598 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 525.486 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 486.760 537.156 55.953 0.750 re f 486.760 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 525.486 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 541.963 537.156 38.912 0.750 re f 541.963 505.278 0.750 32.628 re f 580.125 505.278 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 525.486 Td /F1 9.8 Tf [(2.0)] TJ ET 0.267 0.267 0.267 rg 26.625 505.278 81.984 0.750 re f 26.625 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 493.608 Td /F1 9.8 Tf [(Murgod et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 481.228 Td /F4 8.7 Tf [(68)] TJ ET 0.271 0.267 0.267 rg BT 43.939 480.646 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 505.278 70.818 0.750 re f 107.859 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 493.608 Td /F1 9.8 Tf [(2001)] TJ ET 0.267 0.267 0.267 rg 177.927 505.278 80.585 0.750 re f 177.927 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 493.608 Td /F1 9.8 Tf [(India)] TJ ET 0.267 0.267 0.267 rg 257.761 505.278 47.042 0.750 re f 257.761 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 493.608 Td /F1 9.8 Tf [(26)] TJ ET 0.267 0.267 0.267 rg 304.053 505.278 57.366 0.750 re f 304.053 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 493.608 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 505.278 32.064 0.750 re f 360.669 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 493.608 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 505.278 57.366 0.750 re f 391.983 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 493.608 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 505.278 38.912 0.750 re f 448.598 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 493.608 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 505.278 55.953 0.750 re f 486.760 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 493.608 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 541.963 505.278 38.912 0.750 re f 541.963 473.400 0.750 32.628 re f 580.125 473.400 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 493.608 Td /F1 9.8 Tf [(15.4)] TJ ET 0.267 0.267 0.267 rg 26.625 473.400 81.984 0.750 re f 26.625 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 461.730 Td /F1 9.8 Tf [(Maat Kievit et )] TJ ET BT 31.875 448.768 Td /F1 9.8 Tf [(al)] TJ ET 0.267 0.267 0.267 rg BT 40.562 449.350 Td /F4 8.7 Tf [(68)] TJ ET 0.271 0.267 0.267 rg BT 52.626 448.768 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 473.400 70.818 0.750 re f 107.859 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 461.730 Td /F1 9.8 Tf [(2002)] TJ ET 0.267 0.267 0.267 rg 177.927 473.400 80.585 0.750 re f 177.927 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 461.730 Td /F1 9.8 Tf [(Netherlands)] TJ ET 0.267 0.267 0.267 rg 257.761 473.400 47.042 0.750 re f 257.761 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 461.730 Td /F1 9.8 Tf [(755)] TJ ET 0.267 0.267 0.267 rg 304.053 473.400 57.366 0.750 re f 304.053 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 461.730 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 473.400 32.064 0.750 re f 360.669 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 461.730 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 473.400 57.366 0.750 re f 391.983 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 461.730 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 473.400 38.912 0.750 re f 448.598 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 461.730 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 473.400 55.953 0.750 re f 486.760 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 461.730 Td /F1 9.8 Tf [(18)] TJ ET 0.267 0.267 0.267 rg 541.963 473.400 38.912 0.750 re f 541.963 441.522 0.750 32.628 re f 580.125 441.522 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 461.730 Td /F1 9.8 Tf [(3.0)] TJ ET 0.267 0.267 0.267 rg 26.625 441.522 81.984 0.750 re f 26.625 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 31.875 429.852 Td /F1 9.8 Tf [(Akbas )] TJ ET BT 31.875 419.952 Td /F1 9.8 Tf [(Erginel-)] TJ ET BT 31.875 406.990 Td /F1 9.8 Tf [(Unaltuna)] TJ ET 0.267 0.267 0.267 rg BT 76.042 407.572 Td /F4 8.7 Tf [(69)] TJ ET 0.271 0.267 0.267 rg BT 88.107 406.990 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 441.522 70.818 0.750 re f 107.859 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 113.109 429.852 Td /F1 9.8 Tf [(2003)] TJ ET 0.267 0.267 0.267 rg 177.927 441.522 80.585 0.750 re f 177.927 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 183.177 429.852 Td /F1 9.8 Tf [(Turkey)] TJ ET 0.267 0.267 0.267 rg 257.761 441.522 47.042 0.750 re f 257.761 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 263.011 429.852 Td /F1 9.8 Tf [(127)] TJ ET 0.267 0.267 0.267 rg 304.053 441.522 57.366 0.750 re f 304.053 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 309.303 429.852 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 360.669 441.522 32.064 0.750 re f 360.669 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 365.919 429.852 Td /F1 9.8 Tf [(0.8)] TJ ET 0.267 0.267 0.267 rg 391.983 441.522 57.366 0.750 re f 391.983 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 397.233 429.852 Td /F1 9.8 Tf [(7)] TJ ET 0.267 0.267 0.267 rg 448.598 441.522 38.912 0.750 re f 448.598 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 453.848 429.852 Td /F1 9.8 Tf [(5.5)] TJ ET 0.267 0.267 0.267 rg 486.760 441.522 55.953 0.750 re f 486.760 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 492.010 429.852 Td /F1 9.8 Tf [(8)] TJ ET 0.267 0.267 0.267 rg 541.963 441.522 38.912 0.750 re f 541.963 399.744 0.750 42.528 re f 580.125 399.744 0.750 42.528 re f 0.271 0.267 0.267 rg BT 547.213 429.852 Td /F1 9.8 Tf [(6.3)] TJ ET 0.267 0.267 0.267 rg 26.625 399.744 81.984 0.750 re f 26.625 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 388.074 Td /F1 9.8 Tf [(Creighton et )] TJ ET BT 31.875 375.112 Td /F1 9.8 Tf [(al)] TJ ET 0.267 0.267 0.267 rg BT 40.562 375.694 Td /F4 8.7 Tf [(71)] TJ ET 107.859 399.744 70.818 0.750 re f 107.859 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 388.074 Td /F1 9.8 Tf [(2003)] TJ ET 0.267 0.267 0.267 rg 177.927 399.744 80.585 0.750 re f 177.927 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 388.074 Td /F1 9.8 Tf [(Canada)] TJ ET 0.267 0.267 0.267 rg 257.761 399.744 47.042 0.750 re f 257.761 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 388.074 Td /F1 9.8 Tf [(282)] TJ ET 0.267 0.267 0.267 rg 304.053 399.744 57.366 0.750 re f 304.053 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 388.074 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 399.744 32.064 0.750 re f 360.669 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 388.074 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 399.744 57.366 0.750 re f 391.983 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 388.074 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 399.744 38.912 0.750 re f 448.598 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 388.074 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 399.744 55.953 0.750 re f 486.760 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 388.074 Td /F1 9.8 Tf [(5)] TJ ET 0.267 0.267 0.267 rg 541.963 399.744 38.912 0.750 re f 541.963 367.866 0.750 32.628 re f 580.125 367.866 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 388.074 Td /F1 9.8 Tf [(1.8)] TJ ET 0.267 0.267 0.267 rg 26.625 367.866 81.984 0.750 re f 26.625 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 31.875 356.196 Td /F1 9.8 Tf [(do Como )] TJ ET BT 31.875 346.296 Td /F1 9.8 Tf [(Costa)] TJ ET BT 31.875 333.334 Td /F1 9.8 Tf [(et al)] TJ ET 0.267 0.267 0.267 rg BT 53.481 333.916 Td /F4 8.7 Tf [(72)] TJ ET 107.859 367.866 70.818 0.750 re f 107.859 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 113.109 356.196 Td /F1 9.8 Tf [(2003)] TJ ET 0.267 0.267 0.267 rg 177.927 367.866 80.585 0.750 re f 177.927 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 183.177 356.196 Td /F1 9.8 Tf [(Portugaul)] TJ ET 0.267 0.267 0.267 rg 257.761 367.866 47.042 0.750 re f 257.761 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 263.011 356.196 Td /F1 9.8 Tf [(120)] TJ ET 0.267 0.267 0.267 rg 304.053 367.866 57.366 0.750 re f 304.053 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 309.303 356.196 Td /F1 9.8 Tf [(3)] TJ ET 0.267 0.267 0.267 rg 360.669 367.866 32.064 0.750 re f 360.669 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 365.919 356.196 Td /F1 9.8 Tf [(2.5)] TJ ET 0.267 0.267 0.267 rg 391.983 367.866 57.366 0.750 re f 391.983 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 397.233 356.196 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 448.598 367.866 38.912 0.750 re f 448.598 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 453.848 356.196 Td /F1 9.8 Tf [(0.8)] TJ ET 0.267 0.267 0.267 rg 486.760 367.866 55.953 0.750 re f 486.760 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 492.010 356.196 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 541.963 367.866 38.912 0.750 re f 541.963 326.088 0.750 42.528 re f 580.125 326.088 0.750 42.528 re f 0.271 0.267 0.267 rg BT 547.213 356.196 Td /F1 9.8 Tf [(3.3)] TJ ET 0.267 0.267 0.267 rg 26.625 326.088 81.984 0.750 re f 26.625 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 314.418 Td /F1 9.8 Tf [(Cannella et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 302.038 Td /F4 8.7 Tf [(73)] TJ ET 107.859 326.088 70.818 0.750 re f 107.859 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 314.418 Td /F1 9.8 Tf [(2004)] TJ ET 0.267 0.267 0.267 rg 177.927 326.088 80.585 0.750 re f 177.927 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 314.418 Td /F1 9.8 Tf [(Italy)] TJ ET 0.267 0.267 0.267 rg 257.761 326.088 47.042 0.750 re f 257.761 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 314.418 Td /F1 9.8 Tf [(524)] TJ ET 0.267 0.267 0.267 rg 304.053 326.088 57.366 0.750 re f 304.053 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 314.418 Td /F1 9.8 Tf [(5)] TJ ET 0.267 0.267 0.267 rg 360.669 326.088 32.064 0.750 re f 360.669 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 314.418 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 391.983 326.088 57.366 0.750 re f 391.983 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 314.418 Td /F1 9.8 Tf [(52)] TJ ET 0.267 0.267 0.267 rg 448.598 326.088 38.912 0.750 re f 448.598 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 314.418 Td /F1 9.8 Tf [(9.9)] TJ ET 0.267 0.267 0.267 rg 486.760 326.088 55.953 0.750 re f 486.760 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 314.418 Td /F1 9.8 Tf [(57)] TJ ET 0.267 0.267 0.267 rg 541.963 326.088 38.912 0.750 re f 541.963 294.210 0.750 32.628 re f 580.125 294.210 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 314.418 Td /F1 9.8 Tf [(10.9)] TJ ET 0.267 0.267 0.267 rg 26.625 294.210 81.984 0.750 re f 26.625 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 282.540 Td /F1 9.8 Tf [(Wexler et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 270.160 Td /F4 8.7 Tf [(10)] TJ ET 0.271 0.267 0.267 rg BT 43.939 269.578 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 294.210 70.818 0.750 re f 107.859 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 282.540 Td /F1 9.8 Tf [(2004)] TJ ET 0.267 0.267 0.267 rg 177.927 294.210 80.585 0.750 re f 177.927 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 282.540 Td /F1 9.8 Tf [(Venezueala)] TJ ET 0.267 0.267 0.267 rg 257.761 294.210 47.042 0.750 re f 257.761 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 282.540 Td /F1 9.8 Tf [(443)] TJ ET 0.267 0.267 0.267 rg 304.053 294.210 57.366 0.750 re f 304.053 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 282.540 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 294.210 32.064 0.750 re f 360.669 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 282.540 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 294.210 57.366 0.750 re f 391.983 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 282.540 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 294.210 38.912 0.750 re f 448.598 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 282.540 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 294.210 55.953 0.750 re f 486.760 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 282.540 Td /F1 9.8 Tf [(40)] TJ ET 0.267 0.267 0.267 rg 541.963 294.210 38.912 0.750 re f 541.963 262.332 0.750 32.628 re f 580.125 262.332 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 282.540 Td /F1 9.8 Tf [(9.0)] TJ ET 0.267 0.267 0.267 rg 26.625 262.332 81.984 0.750 re f 26.625 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 250.662 Td /F1 9.8 Tf [(Ramos-Aroyo )] TJ ET BT 31.875 237.700 Td /F1 9.8 Tf [(et al)] TJ ET 0.267 0.267 0.267 rg BT 53.481 238.282 Td /F4 8.7 Tf [(74)] TJ ET 0.271 0.267 0.267 rg BT 65.545 237.700 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 262.332 70.818 0.750 re f 107.859 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 250.662 Td /F1 9.8 Tf [(2005)] TJ ET 0.267 0.267 0.267 rg 177.927 262.332 80.585 0.750 re f 177.927 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 250.662 Td /F1 9.8 Tf [(Spain)] TJ ET 0.267 0.267 0.267 rg 257.761 262.332 47.042 0.750 re f 257.761 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 250.662 Td /F1 9.8 Tf [(112)] TJ ET 0.267 0.267 0.267 rg 304.053 262.332 57.366 0.750 re f 304.053 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 250.662 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 262.332 32.064 0.750 re f 360.669 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 250.662 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 262.332 57.366 0.750 re f 391.983 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 250.662 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 262.332 38.912 0.750 re f 448.598 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 250.662 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 262.332 55.953 0.750 re f 486.760 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 250.662 Td /F1 9.8 Tf [(7)] TJ ET 0.267 0.267 0.267 rg 541.963 262.332 38.912 0.750 re f 541.963 230.454 0.750 32.628 re f 580.125 230.454 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 250.662 Td /F1 9.8 Tf [(6.3)] TJ ET 0.267 0.267 0.267 rg 26.625 230.454 81.984 0.750 re f 26.625 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 218.784 Td /F1 9.8 Tf [(Ruocco et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 206.404 Td /F4 8.7 Tf [(74)] TJ ET 0.271 0.267 0.267 rg BT 43.939 205.822 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 230.454 70.818 0.750 re f 107.859 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 218.784 Td /F1 9.8 Tf [(2006)] TJ ET 0.267 0.267 0.267 rg 177.927 230.454 80.585 0.750 re f 177.927 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 218.784 Td /F1 9.8 Tf [(Brazil)] TJ ET 0.267 0.267 0.267 rg 257.761 230.454 47.042 0.750 re f 257.761 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 218.784 Td /F1 9.8 Tf [(50)] TJ ET 0.267 0.267 0.267 rg 304.053 230.454 57.366 0.750 re f 304.053 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 218.784 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 360.669 230.454 32.064 0.750 re f 360.669 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 218.784 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 391.983 230.454 57.366 0.750 re f 391.983 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 218.784 Td /F1 9.8 Tf [(2)] TJ ET 0.267 0.267 0.267 rg 448.598 230.454 38.912 0.750 re f 448.598 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 218.784 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 486.760 230.454 55.953 0.750 re f 486.760 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 218.784 Td /F1 9.8 Tf [(4)] TJ ET 0.267 0.267 0.267 rg 541.963 230.454 38.912 0.750 re f 541.963 198.576 0.750 32.628 re f 580.125 198.576 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 218.784 Td /F1 9.8 Tf [(8.0)] TJ ET 0.267 0.267 0.267 rg 26.625 198.576 81.984 0.750 re f 26.625 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 31.875 183.844 Td /F1 9.8 Tf [(Ribai et al)] TJ ET 0.267 0.267 0.267 rg BT 84.047 184.426 Td /F4 8.7 Tf [(6)] TJ ET 0.271 0.267 0.267 rg BT 90.079 183.844 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 198.576 70.818 0.750 re f 107.859 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 113.109 186.906 Td /F1 9.8 Tf [(2007)] TJ ET 0.267 0.267 0.267 rg 177.927 198.576 80.585 0.750 re f 177.927 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 183.177 186.906 Td /F1 9.8 Tf [(France)] TJ ET 0.267 0.267 0.267 rg 257.761 198.576 47.042 0.750 re f 257.761 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 263.011 186.906 Td /F1 9.8 Tf [(1453)] TJ ET 0.267 0.267 0.267 rg 304.053 198.576 57.366 0.750 re f 304.053 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 309.303 186.906 Td /F1 9.8 Tf [(8)] TJ ET 0.267 0.267 0.267 rg 360.669 198.576 32.064 0.750 re f 360.669 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 365.919 186.906 Td /F1 9.8 Tf [(0.6)] TJ ET 0.267 0.267 0.267 rg 391.983 198.576 57.366 0.750 re f 391.983 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 397.233 186.906 Td /F1 9.8 Tf [(21)] TJ ET 0.267 0.267 0.267 rg 448.598 198.576 38.912 0.750 re f 448.598 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 453.848 186.906 Td /F1 9.8 Tf [(1.4)] TJ ET 0.267 0.267 0.267 rg 486.760 198.576 55.953 0.750 re f 486.760 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 492.010 186.906 Td /F1 9.8 Tf [(29)] TJ ET 0.267 0.267 0.267 rg 541.963 198.576 38.912 0.750 re f 541.963 176.598 0.750 22.728 re f 580.125 176.598 0.750 22.728 re f 0.271 0.267 0.267 rg BT 547.213 186.906 Td /F1 9.8 Tf [(2.0)] TJ ET 0.267 0.267 0.267 rg 26.625 176.598 81.984 0.750 re f 26.625 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 164.928 Td /F1 9.8 Tf [(Zidovska et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 152.548 Td /F4 8.7 Tf [(76)] TJ ET 0.271 0.267 0.267 rg BT 43.939 151.966 Td /F1 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 107.859 176.598 70.818 0.750 re f 107.859 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 164.928 Td /F1 9.8 Tf [(2007)] TJ ET 0.267 0.267 0.267 rg 177.927 176.598 80.585 0.750 re f 177.927 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 164.928 Td /F1 9.8 Tf [(Czech )] TJ ET BT 183.177 155.028 Td /F1 9.8 Tf [(Republic)] TJ ET 0.267 0.267 0.267 rg 257.761 176.598 47.042 0.750 re f 257.761 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 164.928 Td /F1 9.8 Tf [(411)] TJ ET 0.267 0.267 0.267 rg 304.053 176.598 57.366 0.750 re f 304.053 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 164.928 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 176.598 32.064 0.750 re f 360.669 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 164.928 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 176.598 57.366 0.750 re f 391.983 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 164.928 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 176.598 38.912 0.750 re f 448.598 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 164.928 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 176.598 55.953 0.750 re f 486.760 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 164.928 Td /F1 9.8 Tf [(12)] TJ ET 0.267 0.267 0.267 rg 541.963 176.598 38.912 0.750 re f 541.963 144.720 0.750 32.628 re f 580.125 144.720 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 164.928 Td /F1 9.8 Tf [(2.9)] TJ ET 0.267 0.267 0.267 rg 26.625 144.720 81.984 0.750 re f 26.625 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 133.050 Td /F1 9.8 Tf [(Van Duijn et )] TJ ET BT 31.875 120.088 Td /F1 9.8 Tf [(al)] TJ ET 0.267 0.267 0.267 rg BT 40.562 120.670 Td /F4 8.7 Tf [(77)] TJ ET 107.859 144.720 70.818 0.750 re f 107.859 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 133.050 Td /F1 9.8 Tf [(2008)] TJ ET 0.267 0.267 0.267 rg 177.927 144.720 80.585 0.750 re f 177.927 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 133.050 Td /F1 9.8 Tf [(Netherlands)] TJ ET 0.267 0.267 0.267 rg 257.761 144.720 47.042 0.750 re f 257.761 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 133.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 304.053 144.720 57.366 0.750 re f 304.053 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 133.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 144.720 32.064 0.750 re f 360.669 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 133.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 144.720 57.366 0.750 re f 391.983 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 133.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 144.720 38.912 0.750 re f 448.598 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 133.050 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 144.720 55.953 0.750 re f 486.760 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 133.050 Td /F1 9.8 Tf [(1)] TJ ET 0.267 0.267 0.267 rg 541.963 144.720 38.912 0.750 re f 541.963 112.842 0.750 32.628 re f 580.125 112.842 0.750 32.628 re f 0.271 0.267 0.267 rg BT 547.213 133.050 Td /F1 9.8 Tf [(0.6)] TJ ET 0.267 0.267 0.267 rg 26.625 112.842 81.984 0.750 re f 26.625 80.964 81.984 0.750 re f 26.625 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 31.875 101.172 Td /F1 9.8 Tf [(Alonso et al)] TJ ET 0.267 0.267 0.267 rg BT 31.875 88.792 Td /F4 8.7 Tf [(78)] TJ ET 107.859 112.842 70.818 0.750 re f 107.859 80.964 70.818 0.750 re f 107.859 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 113.109 101.172 Td /F1 9.8 Tf [(2009)] TJ ET 0.267 0.267 0.267 rg 177.927 112.842 80.585 0.750 re f 177.927 80.964 80.585 0.750 re f 177.927 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 183.177 101.172 Td /F1 9.8 Tf [(Mexico)] TJ ET 0.267 0.267 0.267 rg 257.761 112.842 47.042 0.750 re f 257.761 80.964 47.042 0.750 re f 257.761 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 263.011 101.172 Td /F1 9.8 Tf [(691)] TJ ET 0.267 0.267 0.267 rg 304.053 112.842 57.366 0.750 re f 304.053 80.964 57.366 0.750 re f 304.053 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 309.303 101.172 Td /F1 9.8 Tf [(16)] TJ ET 0.267 0.267 0.267 rg 360.669 112.842 32.064 0.750 re f 360.669 80.964 32.064 0.750 re f 360.669 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 365.919 101.172 Td /F1 9.8 Tf [(2.3)] TJ ET 0.267 0.267 0.267 rg 391.983 112.842 57.366 0.750 re f 391.983 80.964 57.366 0.750 re f 391.983 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 397.233 101.172 Td /F1 9.8 Tf [(41)] TJ ET 0.267 0.267 0.267 rg 448.598 112.842 38.912 0.750 re f 448.598 80.964 38.912 0.750 re f 448.598 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 453.848 101.172 Td /F1 9.8 Tf [(5.9)] TJ ET 0.267 0.267 0.267 rg 486.760 112.842 55.953 0.750 re f 486.760 80.964 55.953 0.750 re f 486.760 80.964 0.750 32.628 re f 0.271 0.267 0.267 rg BT 492.010 101.172 Td /F1 9.8 Tf [(57)] TJ ET 0.267 0.267 0.267 rg 541.963 112.842 38.912 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262.636 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 304.428 745.737 56.616 31.263 re f 0.271 0.267 0.267 rg BT 308.928 764.645 Td /F4 9.8 Tf [(0 -10 )] TJ ET BT 308.928 749.201 Td /F4 9.8 Tf [(years)] TJ ET 0.965 0.965 0.965 rg 361.044 745.737 31.314 31.263 re f 0.271 0.267 0.267 rg BT 365.544 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 392.358 745.737 56.616 31.263 re f 0.271 0.267 0.267 rg BT 396.858 764.645 Td /F4 9.8 Tf [(11-20 )] TJ ET BT 396.858 749.201 Td /F4 9.8 Tf [(years)] TJ ET 0.965 0.965 0.965 rg 448.973 745.737 38.162 31.263 re f 0.271 0.267 0.267 rg BT 453.473 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 487.135 745.737 55.203 31.263 re f 0.271 0.267 0.267 rg BT 491.635 764.645 Td /F4 9.8 Tf [(Total )] TJ ET BT 491.635 749.201 Td /F4 9.8 Tf [(JHD)] TJ ET 0.965 0.965 0.965 rg 542.338 745.737 38.162 31.263 re f 0.267 0.267 0.267 rg 580.125 745.362 0.750 31.638 re f 0.271 0.267 0.267 rg BT 546.838 764.645 Td /F4 9.8 Tf [()] TJ ET 0.267 0.267 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0.267 0.267 rg 360.669 745.362 32.064 0.750 re f 360.669 676.746 32.064 0.750 re f 360.669 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 365.919 733.692 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 745.362 57.366 0.750 re f 391.983 676.746 57.366 0.750 re f 391.983 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 397.233 733.692 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 745.362 38.912 0.750 re f 448.598 676.746 38.912 0.750 re f 448.598 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 453.848 733.692 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 745.362 55.953 0.750 re f 486.760 676.746 55.953 0.750 re f 486.760 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 492.010 733.692 Td /F1 9.8 Tf [(9)] TJ ET 0.267 0.267 0.267 rg 541.963 745.362 38.912 0.750 re f 541.963 676.746 38.912 0.750 re f 541.963 676.746 0.750 69.366 re f 580.125 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 547.213 733.692 Td /F1 9.8 Tf [(6.9)] TJ ET BT 26.250 608.665 Td /F4 12.0 Tf [(References)] TJ ET BT 26.250 577.508 Td /F1 9.8 Tf [(1.)] TJ ET BT 39.302 577.508 Td /F1 9.8 Tf [( Orth, Michael; Schwenke, Carsten. Age-at-onset in Huntington disease [Internet]. Version 10. PLoS Currents: )] TJ ET BT 26.250 562.064 Td /F1 9.8 Tf [(Huntington Disease. 2011 Jul 1 [revised 2011 Jul 29]. Available from: http://knol.google.com/k/michael-orth/age-)] TJ ET BT 26.250 546.620 Td /F1 9.8 Tf [(at-onset-in-huntington-disease/3dua5u7tnja1b/3.)] TJ ET BT 26.250 523.676 Td /F1 9.8 Tf [(2.)] TJ ET BT 39.302 523.676 Td /F1 9.8 Tf [(van Dijk JG, van der Velde EA, Roos RAC, Bruyn GW. Juvenile Huntington s disease. Hum Genet 1986;73:235-)] TJ ET BT 26.250 508.232 Td /F1 9.8 Tf [(39.)] TJ ET BT 26.250 485.288 Td /F1 9.8 Tf [(3.)] TJ ET BT 39.302 485.288 Td /F1 9.8 Tf [(Barker RA, Squitieri F. The clinical phenotype of juvenile Huntington s disease. In: Quarrell OWJ, Brewer HM, )] TJ ET BT 26.250 469.844 Td /F1 9.8 Tf [(Squitieri F, Barker RA, Nance MA, Landwehrmeyer BG, eds. Juvenile Huntington s Disease and Other )] TJ ET BT 26.250 454.400 Td /F1 9.8 Tf [(Trinucleotide Repeat Disorders. New York: Oxford University Press; 2009.)] TJ ET BT 26.250 431.456 Td /F1 9.8 Tf [(4.)] TJ ET BT 39.302 431.456 Td /F1 9.8 Tf [(Siesling S, Vegter-van der Vlis M, Roos RAC. Juvenile Huntington disease in the Netherlands. Paed Neurol )] TJ ET BT 26.250 416.012 Td /F1 9.8 Tf [(1997;17:37-43.)] TJ ET BT 26.250 393.068 Td /F1 9.8 Tf [(5.)] TJ ET BT 39.302 393.068 Td /F1 9.8 Tf [(Squitieri F, Frati L, Ciarmiello A, Lastoria S, Quarrell O. Juvenile Huntington s disease: Does a dosage-effect )] TJ ET BT 26.250 377.624 Td /F1 9.8 Tf [(pathogenic mechanism differ from the classical adult disease? Mech Ageing Dev 2006;127:208-212.)] TJ ET BT 26.250 354.680 Td /F1 9.8 Tf [(6.)] TJ ET BT 39.302 354.680 Td /F1 9.8 Tf [(Ribai P, Nguyen K, Hahn-Barma V, et al. Psychiatric and cognitive difficulties as indicators of juvenile )] TJ ET BT 26.250 339.236 Td /F1 9.8 Tf [(Huntington disease onset in 29 patients. Arch Neurol 2007;64:813-19.)] TJ ET BT 26.250 316.292 Td /F1 9.8 Tf [(7.)] TJ ET BT 39.302 316.292 Td /F1 9.8 Tf [(The Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that )] TJ ET BT 26.250 300.848 Td /F1 9.8 Tf [(is expanded and unstable on Huntington's disease chromosomes. Cell 1993;72:971-83.)] TJ ET BT 26.250 277.904 Td /F1 9.8 Tf [(8.)] TJ ET BT 39.302 277.904 Td /F1 9.8 Tf [(ACMG/ASHG. ACMG/ASHG Statement. Laboratory guidelines for Huntington s disease genetic testing. Am J )] TJ ET BT 26.250 262.460 Td /F1 9.8 Tf [(Hum Genet 1998;62:1243 7)] TJ ET BT 26.250 239.516 Td /F1 9.8 Tf [(9.)] TJ ET BT 39.302 239.516 Td /F1 9.8 Tf [(Quarrell OWJ, Nance MA. The diagnostic challenge. In: Quarrell OWJ, Brewer HM, Squitieri F, Barker RA, Nance )] TJ ET BT 26.250 224.072 Td /F1 9.8 Tf [(MA, Landwehrmeyer BG, eds. Juvenile Huntington s Disease and Other Trinucleotide Repeat Disorders. New )] TJ ET BT 26.250 208.628 Td /F1 9.8 Tf [(York: Oxford University Press; 2009.)] TJ ET BT 26.250 185.684 Td /F1 9.8 Tf [(10.)] TJ ET BT 45.502 185.684 Td /F1 9.8 Tf [(The U.S. Venezuela Collaborative Research Project and Wexler N. Venezuelan kindreds reveal that genetic )] TJ ET BT 26.250 170.240 Td /F1 9.8 Tf [(and environmental factors modulate Huntington's disease age of onset. Proc Natl Acad Sci U S A 2004;101:3498-)] TJ ET BT 26.250 154.796 Td /F1 9.8 Tf [(503.)] TJ ET BT 26.250 131.852 Td /F1 9.8 Tf [(11.)] TJ ET BT 45.502 131.852 Td /F1 9.8 Tf [(Hayden MR. Huntington s Chorea. Berlin: Springer-Verlag; 1981)] TJ ET BT 26.250 108.908 Td /F1 9.8 Tf [(12.)] TJ ET BT 45.502 108.908 Td /F1 9.8 Tf [(Harper PS. The epidemiology of Huntington s disease. Hum Genet 1992;89:365-76.)] TJ ET BT 26.250 85.964 Td /F1 9.8 Tf [(13.)] TJ ET BT 45.502 85.964 Td /F1 9.8 Tf [(Morrison PJ, Harding-Lester S, Bradley A. Uptake of Huntington s disease testing in a complete population. )] TJ ET BT 26.250 70.520 Td /F1 9.8 Tf [(Clin Gen 2011;80:281-6.)] TJ ET BT 26.250 47.576 Td /F1 9.8 Tf [(14.)] TJ ET BT 45.502 47.576 Td /F1 9.8 Tf [(Hoppitt T, Calvert M, Pall H, Rickards H, Sackley C. Huntington s disease. Lancet 2010;376:1463-4.)] TJ ET Q q 15.000 36.987 577.500 740.013 re W n 1.000 1.000 1.000 rg 26.250 676.371 555.000 100.629 re f 0.965 0.965 0.965 rg 27.000 745.737 81.234 31.263 re f 0.267 0.267 0.267 rg 26.625 745.362 0.750 31.638 re f 0.271 0.267 0.267 rg BT 31.500 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 108.234 745.737 70.068 31.263 re f 0.271 0.267 0.267 rg BT 112.734 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 178.302 745.737 79.835 31.263 re f 0.271 0.267 0.267 rg BT 182.802 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 258.136 745.737 46.292 31.263 re f 0.271 0.267 0.267 rg BT 262.636 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 304.428 745.737 56.616 31.263 re f 0.271 0.267 0.267 rg BT 308.928 764.645 Td /F4 9.8 Tf [(0 -10 )] TJ ET BT 308.928 749.201 Td /F4 9.8 Tf [(years)] TJ ET 0.965 0.965 0.965 rg 361.044 745.737 31.314 31.263 re f 0.271 0.267 0.267 rg BT 365.544 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 392.358 745.737 56.616 31.263 re f 0.271 0.267 0.267 rg BT 396.858 764.645 Td /F4 9.8 Tf [(11-20 )] TJ ET BT 396.858 749.201 Td /F4 9.8 Tf [(years)] TJ ET 0.965 0.965 0.965 rg 448.973 745.737 38.162 31.263 re f 0.271 0.267 0.267 rg BT 453.473 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 487.135 745.737 55.203 31.263 re f 0.271 0.267 0.267 rg BT 491.635 764.645 Td /F4 9.8 Tf [(Total )] TJ ET BT 491.635 749.201 Td /F4 9.8 Tf [(JHD)] TJ ET 0.965 0.965 0.965 rg 542.338 745.737 38.162 31.263 re f 0.267 0.267 0.267 rg 580.125 745.362 0.750 31.638 re f 0.271 0.267 0.267 rg BT 546.838 764.645 Td /F4 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 26.625 745.362 81.984 0.750 re f 26.625 676.746 81.984 0.750 re f 26.625 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 31.875 730.630 Td /F1 9.8 Tf [(Torres et al)] TJ ET 0.267 0.267 0.267 rg BT 90.697 731.212 Td /F4 8.7 Tf [(79)] TJ ET 107.859 745.362 70.818 0.750 re f 107.859 676.746 70.818 0.750 re f 107.859 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 113.109 733.692 Td /F1 9.8 Tf [(2010)] TJ ET 0.267 0.267 0.267 rg 177.927 745.362 80.585 0.750 re f 177.927 676.746 80.585 0.750 re f 177.927 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 183.177 733.692 Td /F1 9.8 Tf [(Peru)] TJ ET 0.267 0.267 0.267 rg 257.761 745.362 47.042 0.750 re f 257.761 676.746 47.042 0.750 re f 257.761 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 263.011 733.692 Td /F1 9.8 Tf [(131)] TJ ET 0.267 0.267 0.267 rg 304.053 745.362 57.366 0.750 re f 304.053 676.746 57.366 0.750 re f 304.053 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 309.303 733.692 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 745.362 32.064 0.750 re f 360.669 676.746 32.064 0.750 re f 360.669 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 365.919 733.692 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 745.362 57.366 0.750 re f 391.983 676.746 57.366 0.750 re f 391.983 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 397.233 733.692 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 745.362 38.912 0.750 re f 448.598 676.746 38.912 0.750 re f 448.598 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 453.848 733.692 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 745.362 55.953 0.750 re f 486.760 676.746 55.953 0.750 re f 486.760 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 492.010 733.692 Td /F1 9.8 Tf [(9)] TJ ET 0.267 0.267 0.267 rg 541.963 745.362 38.912 0.750 re f 541.963 676.746 38.912 0.750 re f 541.963 676.746 0.750 69.366 re f 580.125 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 547.213 733.692 Td /F1 9.8 Tf [(6.9)] TJ ET BT 26.250 608.665 Td /F4 12.0 Tf [(References)] TJ ET BT 26.250 577.508 Td /F1 9.8 Tf [(1.)] TJ ET BT 39.302 577.508 Td /F1 9.8 Tf [( Orth, Michael; Schwenke, Carsten. Age-at-onset in Huntington disease [Internet]. Version 10. PLoS Currents: )] TJ ET BT 26.250 562.064 Td /F1 9.8 Tf [(Huntington Disease. 2011 Jul 1 [revised 2011 Jul 29]. Available from: http://knol.google.com/k/michael-orth/age-)] TJ ET BT 26.250 546.620 Td /F1 9.8 Tf [(at-onset-in-huntington-disease/3dua5u7tnja1b/3.)] TJ ET BT 26.250 523.676 Td /F1 9.8 Tf [(2.)] TJ ET BT 39.302 523.676 Td /F1 9.8 Tf [(van Dijk JG, van der Velde EA, Roos RAC, Bruyn GW. Juvenile Huntington s disease. Hum Genet 1986;73:235-)] TJ ET BT 26.250 508.232 Td /F1 9.8 Tf [(39.)] TJ ET BT 26.250 485.288 Td /F1 9.8 Tf [(3.)] TJ ET BT 39.302 485.288 Td /F1 9.8 Tf [(Barker RA, Squitieri F. The clinical phenotype of juvenile Huntington s disease. In: Quarrell OWJ, Brewer HM, )] TJ ET BT 26.250 469.844 Td /F1 9.8 Tf [(Squitieri F, Barker RA, Nance MA, Landwehrmeyer BG, eds. Juvenile Huntington s Disease and Other )] TJ ET BT 26.250 454.400 Td /F1 9.8 Tf [(Trinucleotide Repeat Disorders. New York: Oxford University Press; 2009.)] TJ ET BT 26.250 431.456 Td /F1 9.8 Tf [(4.)] TJ ET BT 39.302 431.456 Td /F1 9.8 Tf [(Siesling S, Vegter-van der Vlis M, Roos RAC. Juvenile Huntington disease in the Netherlands. Paed Neurol )] TJ ET BT 26.250 416.012 Td /F1 9.8 Tf [(1997;17:37-43.)] TJ ET BT 26.250 393.068 Td /F1 9.8 Tf [(5.)] TJ ET BT 39.302 393.068 Td /F1 9.8 Tf [(Squitieri F, Frati L, Ciarmiello A, Lastoria S, Quarrell O. Juvenile Huntington s disease: Does a dosage-effect )] TJ ET BT 26.250 377.624 Td /F1 9.8 Tf [(pathogenic mechanism differ from the classical adult disease? Mech Ageing Dev 2006;127:208-212.)] TJ ET BT 26.250 354.680 Td /F1 9.8 Tf [(6.)] TJ ET BT 39.302 354.680 Td /F1 9.8 Tf [(Ribai P, Nguyen K, Hahn-Barma V, et al. Psychiatric and cognitive difficulties as indicators of juvenile )] TJ ET BT 26.250 339.236 Td /F1 9.8 Tf [(Huntington disease onset in 29 patients. Arch Neurol 2007;64:813-19.)] TJ ET BT 26.250 316.292 Td /F1 9.8 Tf [(7.)] TJ ET BT 39.302 316.292 Td /F1 9.8 Tf [(The Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that )] TJ ET BT 26.250 300.848 Td /F1 9.8 Tf [(is expanded and unstable on Huntington's disease chromosomes. Cell 1993;72:971-83.)] TJ ET BT 26.250 277.904 Td /F1 9.8 Tf [(8.)] TJ ET BT 39.302 277.904 Td /F1 9.8 Tf [(ACMG/ASHG. ACMG/ASHG Statement. Laboratory guidelines for Huntington s disease genetic testing. Am J )] TJ ET BT 26.250 262.460 Td /F1 9.8 Tf [(Hum Genet 1998;62:1243 7)] TJ ET BT 26.250 239.516 Td /F1 9.8 Tf [(9.)] TJ ET BT 39.302 239.516 Td /F1 9.8 Tf [(Quarrell OWJ, Nance MA. The diagnostic challenge. In: Quarrell OWJ, Brewer HM, Squitieri F, Barker RA, Nance )] TJ ET BT 26.250 224.072 Td /F1 9.8 Tf [(MA, Landwehrmeyer BG, eds. Juvenile Huntington s Disease and Other Trinucleotide Repeat Disorders. New )] TJ ET BT 26.250 208.628 Td /F1 9.8 Tf [(York: Oxford University Press; 2009.)] TJ ET BT 26.250 185.684 Td /F1 9.8 Tf [(10.)] TJ ET BT 45.502 185.684 Td /F1 9.8 Tf [(The U.S. Venezuela Collaborative Research Project and Wexler N. Venezuelan kindreds reveal that genetic )] TJ ET BT 26.250 170.240 Td /F1 9.8 Tf [(and environmental factors modulate Huntington's disease age of onset. Proc Natl Acad Sci U S A 2004;101:3498-)] TJ ET BT 26.250 154.796 Td /F1 9.8 Tf [(503.)] TJ ET BT 26.250 131.852 Td /F1 9.8 Tf [(11.)] TJ ET BT 45.502 131.852 Td /F1 9.8 Tf [(Hayden MR. Huntington s Chorea. Berlin: Springer-Verlag; 1981)] TJ ET BT 26.250 108.908 Td /F1 9.8 Tf [(12.)] TJ ET BT 45.502 108.908 Td /F1 9.8 Tf [(Harper PS. The epidemiology of Huntington s disease. Hum Genet 1992;89:365-76.)] TJ ET BT 26.250 85.964 Td /F1 9.8 Tf [(13.)] TJ ET BT 45.502 85.964 Td /F1 9.8 Tf [(Morrison PJ, Harding-Lester S, Bradley A. Uptake of Huntington s disease testing in a complete population. )] TJ ET BT 26.250 70.520 Td /F1 9.8 Tf [(Clin Gen 2011;80:281-6.)] TJ ET BT 26.250 47.576 Td /F1 9.8 Tf [(14.)] TJ ET BT 45.502 47.576 Td /F1 9.8 Tf [(Hoppitt T, Calvert M, Pall H, Rickards H, Sackley C. Huntington s disease. Lancet 2010;376:1463-4.)] TJ ET Q q 15.000 36.987 577.500 740.013 re W n 1.000 1.000 1.000 rg 26.250 676.371 555.000 100.629 re f 0.965 0.965 0.965 rg 27.000 745.737 81.234 31.263 re f 0.267 0.267 0.267 rg 26.625 745.362 0.750 31.638 re f 0.271 0.267 0.267 rg BT 31.500 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 108.234 745.737 70.068 31.263 re f 0.271 0.267 0.267 rg BT 112.734 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 178.302 745.737 79.835 31.263 re f 0.271 0.267 0.267 rg BT 182.802 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 258.136 745.737 46.292 31.263 re f 0.271 0.267 0.267 rg BT 262.636 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 304.428 745.737 56.616 31.263 re f 0.271 0.267 0.267 rg BT 308.928 764.645 Td /F4 9.8 Tf [(0 -10 )] TJ ET BT 308.928 749.201 Td /F4 9.8 Tf [(years)] TJ ET 0.965 0.965 0.965 rg 361.044 745.737 31.314 31.263 re f 0.271 0.267 0.267 rg BT 365.544 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 392.358 745.737 56.616 31.263 re f 0.271 0.267 0.267 rg BT 396.858 764.645 Td /F4 9.8 Tf [(11-20 )] TJ ET BT 396.858 749.201 Td /F4 9.8 Tf [(years)] TJ ET 0.965 0.965 0.965 rg 448.973 745.737 38.162 31.263 re f 0.271 0.267 0.267 rg BT 453.473 764.645 Td /F4 9.8 Tf [()] TJ ET 0.965 0.965 0.965 rg 487.135 745.737 55.203 31.263 re f 0.271 0.267 0.267 rg BT 491.635 764.645 Td /F4 9.8 Tf [(Total )] TJ ET BT 491.635 749.201 Td /F4 9.8 Tf [(JHD)] TJ ET 0.965 0.965 0.965 rg 542.338 745.737 38.162 31.263 re f 0.267 0.267 0.267 rg 580.125 745.362 0.750 31.638 re f 0.271 0.267 0.267 rg BT 546.838 764.645 Td /F4 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg 26.625 745.362 81.984 0.750 re f 26.625 676.746 81.984 0.750 re f 26.625 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 31.875 730.630 Td /F1 9.8 Tf [(Torres et al)] TJ ET 0.267 0.267 0.267 rg BT 90.697 731.212 Td /F4 8.7 Tf [(79)] TJ ET 107.859 745.362 70.818 0.750 re f 107.859 676.746 70.818 0.750 re f 107.859 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 113.109 733.692 Td /F1 9.8 Tf [(2010)] TJ ET 0.267 0.267 0.267 rg 177.927 745.362 80.585 0.750 re f 177.927 676.746 80.585 0.750 re f 177.927 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 183.177 733.692 Td /F1 9.8 Tf [(Peru)] TJ ET 0.267 0.267 0.267 rg 257.761 745.362 47.042 0.750 re f 257.761 676.746 47.042 0.750 re f 257.761 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 263.011 733.692 Td /F1 9.8 Tf [(131)] TJ ET 0.267 0.267 0.267 rg 304.053 745.362 57.366 0.750 re f 304.053 676.746 57.366 0.750 re f 304.053 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 309.303 733.692 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 360.669 745.362 32.064 0.750 re f 360.669 676.746 32.064 0.750 re f 360.669 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 365.919 733.692 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 391.983 745.362 57.366 0.750 re f 391.983 676.746 57.366 0.750 re f 391.983 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 397.233 733.692 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 448.598 745.362 38.912 0.750 re f 448.598 676.746 38.912 0.750 re f 448.598 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 453.848 733.692 Td /F1 9.8 Tf [(-)] TJ ET 0.267 0.267 0.267 rg 486.760 745.362 55.953 0.750 re f 486.760 676.746 55.953 0.750 re f 486.760 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 492.010 733.692 Td /F1 9.8 Tf [(9)] TJ ET 0.267 0.267 0.267 rg 541.963 745.362 38.912 0.750 re f 541.963 676.746 38.912 0.750 re f 541.963 676.746 0.750 69.366 re f 580.125 676.746 0.750 69.366 re f 0.271 0.267 0.267 rg BT 547.213 733.692 Td /F1 9.8 Tf [(6.9)] TJ ET BT 26.250 608.665 Td /F4 12.0 Tf [(References)] TJ ET BT 26.250 577.508 Td /F1 9.8 Tf [(1.)] TJ ET BT 39.302 577.508 Td /F1 9.8 Tf [( Orth, Michael; Schwenke, Carsten. Age-at-onset in Huntington disease [Internet]. Version 10. PLoS Currents: )] TJ ET BT 26.250 562.064 Td /F1 9.8 Tf [(Huntington Disease. 2011 Jul 1 [revised 2011 Jul 29]. Available from: http://knol.google.com/k/michael-orth/age-)] TJ ET BT 26.250 546.620 Td /F1 9.8 Tf [(at-onset-in-huntington-disease/3dua5u7tnja1b/3.)] TJ ET BT 26.250 523.676 Td /F1 9.8 Tf [(2.)] TJ ET BT 39.302 523.676 Td /F1 9.8 Tf [(van Dijk JG, van der Velde EA, Roos RAC, Bruyn GW. Juvenile Huntington s disease. Hum Genet 1986;73:235-)] TJ ET BT 26.250 508.232 Td /F1 9.8 Tf [(39.)] TJ ET BT 26.250 485.288 Td /F1 9.8 Tf [(3.)] TJ ET BT 39.302 485.288 Td /F1 9.8 Tf [(Barker RA, Squitieri F. The clinical phenotype of juvenile Huntington s disease. In: Quarrell OWJ, Brewer HM, )] TJ ET BT 26.250 469.844 Td /F1 9.8 Tf [(Squitieri F, Barker RA, Nance MA, Landwehrmeyer BG, eds. Juvenile Huntington s Disease and Other )] TJ ET BT 26.250 454.400 Td /F1 9.8 Tf [(Trinucleotide Repeat Disorders. New York: Oxford University Press; 2009.)] TJ ET BT 26.250 431.456 Td /F1 9.8 Tf [(4.)] TJ ET BT 39.302 431.456 Td /F1 9.8 Tf [(Siesling S, Vegter-van der Vlis M, Roos RAC. Juvenile Huntington disease in the Netherlands. Paed Neurol )] TJ ET BT 26.250 416.012 Td /F1 9.8 Tf [(1997;17:37-43.)] TJ ET BT 26.250 393.068 Td /F1 9.8 Tf [(5.)] TJ ET BT 39.302 393.068 Td /F1 9.8 Tf [(Squitieri F, Frati L, Ciarmiello A, Lastoria S, Quarrell O. Juvenile Huntington s disease: Does a dosage-effect )] TJ ET BT 26.250 377.624 Td /F1 9.8 Tf [(pathogenic mechanism differ from the classical adult disease? Mech Ageing Dev 2006;127:208-212.)] TJ ET BT 26.250 354.680 Td /F1 9.8 Tf [(6.)] TJ ET BT 39.302 354.680 Td /F1 9.8 Tf [(Ribai P, Nguyen K, Hahn-Barma V, et al. Psychiatric and cognitive difficulties as indicators of juvenile )] TJ ET BT 26.250 339.236 Td /F1 9.8 Tf [(Huntington disease onset in 29 patients. Arch Neurol 2007;64:813-19.)] TJ ET BT 26.250 316.292 Td /F1 9.8 Tf [(7.)] TJ ET BT 39.302 316.292 Td /F1 9.8 Tf [(The Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that )] TJ ET BT 26.250 300.848 Td /F1 9.8 Tf [(is expanded and unstable on Huntington's disease chromosomes. Cell 1993;72:971-83.)] TJ ET BT 26.250 277.904 Td /F1 9.8 Tf [(8.)] TJ ET BT 39.302 277.904 Td /F1 9.8 Tf [(ACMG/ASHG. ACMG/ASHG Statement. Laboratory guidelines for Huntington s disease genetic testing. Am J )] TJ ET BT 26.250 262.460 Td /F1 9.8 Tf [(Hum Genet 1998;62:1243 7)] TJ ET BT 26.250 239.516 Td /F1 9.8 Tf [(9.)] TJ ET BT 39.302 239.516 Td /F1 9.8 Tf [(Quarrell OWJ, Nance MA. The diagnostic challenge. In: Quarrell OWJ, Brewer HM, Squitieri F, Barker RA, Nance )] TJ ET BT 26.250 224.072 Td /F1 9.8 Tf [(MA, Landwehrmeyer BG, eds. Juvenile Huntington s Disease and Other Trinucleotide Repeat Disorders. New )] TJ ET BT 26.250 208.628 Td /F1 9.8 Tf [(York: Oxford University Press; 2009.)] TJ ET BT 26.250 185.684 Td /F1 9.8 Tf [(10.)] TJ ET BT 45.502 185.684 Td /F1 9.8 Tf [(The U.S. Venezuela Collaborative Research Project and Wexler N. Venezuelan kindreds reveal that genetic )] TJ ET BT 26.250 170.240 Td /F1 9.8 Tf [(and environmental factors modulate Huntington's disease age of onset. Proc Natl Acad Sci U S A 2004;101:3498-)] TJ ET BT 26.250 154.796 Td /F1 9.8 Tf [(503.)] TJ ET BT 26.250 131.852 Td /F1 9.8 Tf [(11.)] TJ ET BT 45.502 131.852 Td /F1 9.8 Tf [(Hayden MR. Huntington s Chorea. Berlin: Springer-Verlag; 1981)] TJ ET BT 26.250 108.908 Td /F1 9.8 Tf [(12.)] TJ ET BT 45.502 108.908 Td /F1 9.8 Tf [(Harper PS. The epidemiology of Huntington s disease. Hum Genet 1992;89:365-76.)] TJ ET BT 26.250 85.964 Td /F1 9.8 Tf [(13.)] TJ ET BT 45.502 85.964 Td /F1 9.8 Tf [(Morrison PJ, Harding-Lester S, Bradley A. Uptake of Huntington s disease testing in a complete population. )] TJ ET BT 26.250 70.520 Td /F1 9.8 Tf [(Clin Gen 2011;80:281-6.)] TJ ET BT 26.250 47.576 Td /F1 9.8 Tf [(14.)] TJ ET BT 45.502 47.576 Td /F1 9.8 Tf [(Hoppitt T, Calvert M, Pall H, Rickards H, Sackley C. Huntington s disease. Lancet 2010;376:1463-4.)] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 18.032 Td /F5 11.0 Tf [(16)] TJ ET BT 25.000 18.032 Td /F5 11.0 Tf [(PLOS Currents Huntington Disease)] TJ ET Q endstream endobj 867 0 obj << /Type /Annot /Subtype /Link /A 868 0 R /Border [0 0 0] /H /I /Rect [ 90.6968 730.1720 102.7608 741.6120 ] >> endobj 868 0 obj << /Type /Action >> endobj 869 0 obj << /Type /Annot /Subtype /Link /A 870 0 R /Border [0 0 0] /H /I /Rect [ 90.6968 730.1720 102.7608 741.6120 ] >> endobj 870 0 obj << /Type /Action >> endobj 871 0 obj << /Type /Annot /Subtype /Link /A 872 0 R /Border [0 0 0] /H /I /Rect [ 90.6968 730.1720 102.7608 741.6120 ] >> endobj 872 0 obj << /Type /Action >> endobj 873 0 obj << /Type /Page /Parent 3 0 R /Contents 874 0 R >> endobj 874 0 obj << /Length 24753 >> stream 0.271 0.267 0.267 rg q 15.000 40.572 577.500 736.428 re W n 0.271 0.267 0.267 rg BT 26.250 757.145 Td /F1 9.8 Tf [(15.)] TJ ET BT 45.502 757.145 Td /F1 9.8 Tf [(Rawlins M. Huntington s disease out of the closet? Lancet 2010;376:1372-3.)] TJ ET BT 26.250 734.201 Td /F1 9.8 Tf [(16.)] TJ ET BT 45.502 734.201 Td /F1 9.8 Tf [(Warby SC, Visscher H, Collins JA, Doty CN et al. HTT haplotypes contribute to differences in Huntington s )] TJ ET BT 26.250 718.757 Td /F1 9.8 Tf [(disease prevalence between Europe and Eas Asia Europ J Hum Genet 2011; 19:561-566.)] TJ ET BT 26.250 695.813 Td /F1 9.8 Tf [(17.)] TJ ET BT 45.502 695.813 Td /F1 9.8 Tf [(Hayden MR, MacGregor, JM, Beighton, PH. The prevalence of Huntington s Chorea in South Africa. S Afr Med )] TJ ET BT 26.250 680.369 Td /F1 9.8 Tf [(J 1980;58:193-6.)] TJ ET BT 26.250 657.425 Td /F1 9.8 Tf [(18.)] TJ ET BT 45.502 657.425 Td /F1 9.8 Tf [(Reed TE, Chandler JH, Hughes EM, Davidson RT. Huntington s Chorea in Michigan: Demography and )] TJ ET BT 26.250 641.981 Td /F1 9.8 Tf [(genetics. Am J Hum Genet 1958;10:201-25.)] TJ ET BT 26.250 619.037 Td /F1 9.8 Tf [(19.)] TJ ET BT 45.502 619.037 Td /F1 9.8 Tf [(Folstein SE, Chase GA, Wahl WE, McDonnell AM, Folstein, MF. Huntington disease in Maryland: clinical )] TJ ET BT 26.250 603.593 Td /F1 9.8 Tf [(aspects of racial variation. Am J Hum Genet 1987;41:168-79.)] TJ ET BT 26.250 580.649 Td /F1 9.8 Tf [(20.)] TJ ET BT 45.502 580.649 Td /F1 9.8 Tf [(Panse F. Die Erbchorea: Eine klinische-genetische studie. Samml Psychiatr Neurol Einzeldarst, 18. Leipzig: )] TJ ET BT 26.250 565.205 Td /F1 9.8 Tf [(Thieme; 1942.)] TJ ET BT 26.250 542.261 Td /F1 9.8 Tf [(21.)] TJ ET BT 45.502 542.261 Td /F1 9.8 Tf [(The World Bank. Country Classifications, 2012. Available from http://data.worldbank.org/about/country-)] TJ ET BT 26.250 526.817 Td /F1 9.8 Tf [(classifications.)] TJ ET BT 26.250 503.873 Td /F1 9.8 Tf [(22.)] TJ ET BT 45.502 503.873 Td /F1 9.8 Tf [(R Development Core Team \(2011\). R: A Language and Environment for Statistical Computing, R Foundation )] TJ ET BT 26.250 488.429 Td /F1 9.8 Tf [(for Statistical Computing, Vienna, Austria, ISBN 3-900051-07-0.)] TJ ET BT 26.250 465.485 Td /F1 9.8 Tf [(23.)] TJ ET BT 45.502 465.485 Td /F1 9.8 Tf [(Bell J. Nervous Diseases and Muscular Dystrophies. In: Fisher RA, Penrose S, eds. The Treasury of Human )] TJ ET BT 26.250 450.041 Td /F1 9.8 Tf [(Inheritance. Vol IV. Cambridge: Cambridge University Press, pp.1-69; 1948.)] TJ ET BT 26.250 427.097 Td /F1 9.8 Tf [(24.)] TJ ET BT 45.502 427.097 Td /F1 9.8 Tf [(Cameron D, Venters GA. Some problems in Huntington s chorea. Scott Med J. 1967;12\(4\):152-6.)] TJ ET BT 26.250 404.153 Td /F1 9.8 Tf [(25.)] TJ ET BT 45.502 404.153 Td /F1 9.8 Tf [(Bickford JAR, Ellison RM. The high incidence of Huntington s chorea in the Duchy of Cornwall. J Ment Sci. )] TJ ET BT 26.250 388.709 Td /F1 9.8 Tf [(1953;99\(415\):291-4.)] TJ ET BT 26.250 365.765 Td /F1 9.8 Tf [(26.)] TJ ET BT 45.502 365.765 Td /F1 9.8 Tf [(Pleydell MJ. Huntington s chorea in Northamptonshire. Br Med J. 1954;2\(4897\):1121-8.)] TJ ET BT 26.250 342.821 Td /F1 9.8 Tf [(27.)] TJ ET BT 45.502 342.821 Td /F1 9.8 Tf [(Pleydell MJ. Huntington s chorea in Northamptonshire. Br Med J. 1955;2\(4944\):889.)] TJ ET BT 26.250 319.877 Td /F1 9.8 Tf [(28.)] TJ ET BT 45.502 319.877 Td /F1 9.8 Tf [(Hayden MR, MacGregor JM, Saffer DS, Beighton PH. The high frequency of juvenile Huntington s chorea in )] TJ ET BT 26.250 304.433 Td /F1 9.8 Tf [(South Africa. J Med Genet. 1982;19\(2\):94-7.)] TJ ET BT 26.250 281.489 Td /F1 9.8 Tf [(29.)] TJ ET BT 45.502 281.489 Td /F1 9.8 Tf [(Davenport CB, Muncey, EB. Huntington s Chorea in relation to history and eugenics. Am J Insan. )] TJ ET BT 26.250 266.045 Td /F1 9.8 Tf [(1916;73:195-222.)] TJ ET BT 26.250 243.101 Td /F1 9.8 Tf [(30.)] TJ ET BT 45.502 243.101 Td /F1 9.8 Tf [(Spillane J, Phillips R. Huntington s Chorea in South Wales. Q J Med. 1937;6:403-423.)] TJ ET BT 26.250 220.157 Td /F1 9.8 Tf [(31.)] TJ ET BT 45.502 220.157 Td /F1 9.8 Tf [(Brothers CR. Huntington s Chorea in Victoria and Tasmania. J Neurol Sci. 1964;1:405-420.)] TJ ET BT 26.250 197.213 Td /F1 9.8 Tf [(32.)] TJ ET BT 45.502 197.213 Td /F1 9.8 Tf [(Heathfield KWG. Huntington s chorea: Investigation into the prevalence of this disease in the area covered )] TJ ET BT 26.250 181.769 Td /F1 9.8 Tf [(by the North East Metropolitan Regional Hospital Board. Brain. 1967;90:203-232.)] TJ ET BT 26.250 158.825 Td /F1 9.8 Tf [(33.)] TJ ET BT 45.502 158.825 Td /F1 9.8 Tf [(Oliver JE. Huntington s chorea in Northamptonshire. Br J Psychiatry. 1970;116:241-253.)] TJ ET BT 26.250 135.881 Td /F1 9.8 Tf [(34.)] TJ ET BT 45.502 135.881 Td /F1 9.8 Tf [(Mattsson B. Clinical, genetic and pharmacological studies in Huntington s chorea. UMEA University Medical )] TJ ET BT 26.250 120.437 Td /F1 9.8 Tf [(Dissertations 7. Sweden: UMEA:21-51; 1974.)] TJ ET BT 26.250 97.493 Td /F1 9.8 Tf [(35.)] TJ ET BT 45.502 97.493 Td /F1 9.8 Tf [(Stevens DL. Huntington s chorea: a demographic, genetic and clinical study. MD thesis, University of )] TJ ET BT 26.250 82.049 Td /F1 9.8 Tf [(London, pp. 1-338; 1976.)] TJ ET BT 26.250 59.105 Td /F1 9.8 Tf [(36.)] TJ ET BT 45.502 59.105 Td /F1 9.8 Tf [(Walker DA, Harper PS, Wells CEC, Tyler A, Davies K, Newcombe RG. Huntington's Chorea in South Wales A )] TJ ET Q q 15.000 40.572 577.500 736.428 re W n 0.271 0.267 0.267 rg BT 26.250 757.145 Td /F1 9.8 Tf [(15.)] TJ ET BT 45.502 757.145 Td /F1 9.8 Tf [(Rawlins M. Huntington s disease out of the closet? Lancet 2010;376:1372-3.)] TJ ET BT 26.250 734.201 Td /F1 9.8 Tf [(16.)] TJ ET BT 45.502 734.201 Td /F1 9.8 Tf [(Warby SC, Visscher H, Collins JA, Doty CN et al. HTT haplotypes contribute to differences in Huntington s )] TJ ET BT 26.250 718.757 Td /F1 9.8 Tf [(disease prevalence between Europe and Eas Asia Europ J Hum Genet 2011; 19:561-566.)] TJ ET BT 26.250 695.813 Td /F1 9.8 Tf [(17.)] TJ ET BT 45.502 695.813 Td /F1 9.8 Tf [(Hayden MR, MacGregor, JM, Beighton, PH. The prevalence of Huntington s Chorea in South Africa. S Afr Med )] TJ ET BT 26.250 680.369 Td /F1 9.8 Tf [(J 1980;58:193-6.)] TJ ET BT 26.250 657.425 Td /F1 9.8 Tf [(18.)] TJ ET BT 45.502 657.425 Td /F1 9.8 Tf [(Reed TE, Chandler JH, Hughes EM, Davidson RT. Huntington s Chorea in Michigan: Demography and )] TJ ET BT 26.250 641.981 Td /F1 9.8 Tf [(genetics. Am J Hum Genet 1958;10:201-25.)] TJ ET BT 26.250 619.037 Td /F1 9.8 Tf [(19.)] TJ ET BT 45.502 619.037 Td /F1 9.8 Tf [(Folstein SE, Chase GA, Wahl WE, McDonnell AM, Folstein, MF. Huntington disease in Maryland: clinical )] TJ ET BT 26.250 603.593 Td /F1 9.8 Tf [(aspects of racial variation. Am J Hum Genet 1987;41:168-79.)] TJ ET BT 26.250 580.649 Td /F1 9.8 Tf [(20.)] TJ ET BT 45.502 580.649 Td /F1 9.8 Tf [(Panse F. Die Erbchorea: Eine klinische-genetische studie. Samml Psychiatr Neurol Einzeldarst, 18. Leipzig: )] TJ ET BT 26.250 565.205 Td /F1 9.8 Tf [(Thieme; 1942.)] TJ ET BT 26.250 542.261 Td /F1 9.8 Tf [(21.)] TJ ET BT 45.502 542.261 Td /F1 9.8 Tf [(The World Bank. Country Classifications, 2012. Available from http://data.worldbank.org/about/country-)] TJ ET BT 26.250 526.817 Td /F1 9.8 Tf [(classifications.)] TJ ET BT 26.250 503.873 Td /F1 9.8 Tf [(22.)] TJ ET BT 45.502 503.873 Td /F1 9.8 Tf [(R Development Core Team \(2011\). R: A Language and Environment for Statistical Computing, R Foundation )] TJ ET BT 26.250 488.429 Td /F1 9.8 Tf [(for Statistical Computing, Vienna, Austria, ISBN 3-900051-07-0.)] TJ ET BT 26.250 465.485 Td /F1 9.8 Tf [(23.)] TJ ET BT 45.502 465.485 Td /F1 9.8 Tf [(Bell J. Nervous Diseases and Muscular Dystrophies. In: Fisher RA, Penrose S, eds. The Treasury of Human )] TJ ET BT 26.250 450.041 Td /F1 9.8 Tf [(Inheritance. Vol IV. Cambridge: Cambridge University Press, pp.1-69; 1948.)] TJ ET BT 26.250 427.097 Td /F1 9.8 Tf [(24.)] TJ ET BT 45.502 427.097 Td /F1 9.8 Tf [(Cameron D, Venters GA. Some problems in Huntington s chorea. Scott Med J. 1967;12\(4\):152-6.)] TJ ET BT 26.250 404.153 Td /F1 9.8 Tf [(25.)] TJ ET BT 45.502 404.153 Td /F1 9.8 Tf [(Bickford JAR, Ellison RM. The high incidence of Huntington s chorea in the Duchy of Cornwall. J Ment Sci. )] TJ ET BT 26.250 388.709 Td /F1 9.8 Tf [(1953;99\(415\):291-4.)] TJ ET BT 26.250 365.765 Td /F1 9.8 Tf [(26.)] TJ ET BT 45.502 365.765 Td /F1 9.8 Tf [(Pleydell MJ. Huntington s chorea in Northamptonshire. Br Med J. 1954;2\(4897\):1121-8.)] TJ ET BT 26.250 342.821 Td /F1 9.8 Tf [(27.)] TJ ET BT 45.502 342.821 Td /F1 9.8 Tf [(Pleydell MJ. Huntington s chorea in Northamptonshire. Br Med J. 1955;2\(4944\):889.)] TJ ET BT 26.250 319.877 Td /F1 9.8 Tf [(28.)] TJ ET BT 45.502 319.877 Td /F1 9.8 Tf [(Hayden MR, MacGregor JM, Saffer DS, Beighton PH. The high frequency of juvenile Huntington s chorea in )] TJ ET BT 26.250 304.433 Td /F1 9.8 Tf [(South Africa. J Med Genet. 1982;19\(2\):94-7.)] TJ ET BT 26.250 281.489 Td /F1 9.8 Tf [(29.)] TJ ET BT 45.502 281.489 Td /F1 9.8 Tf [(Davenport CB, Muncey, EB. Huntington s Chorea in relation to history and eugenics. Am J Insan. )] TJ ET BT 26.250 266.045 Td /F1 9.8 Tf [(1916;73:195-222.)] TJ ET BT 26.250 243.101 Td /F1 9.8 Tf [(30.)] TJ ET BT 45.502 243.101 Td /F1 9.8 Tf [(Spillane J, Phillips R. Huntington s Chorea in South Wales. Q J Med. 1937;6:403-423.)] TJ ET BT 26.250 220.157 Td /F1 9.8 Tf [(31.)] TJ ET BT 45.502 220.157 Td /F1 9.8 Tf [(Brothers CR. Huntington s Chorea in Victoria and Tasmania. J Neurol Sci. 1964;1:405-420.)] TJ ET BT 26.250 197.213 Td /F1 9.8 Tf [(32.)] TJ ET BT 45.502 197.213 Td /F1 9.8 Tf [(Heathfield KWG. Huntington s chorea: Investigation into the prevalence of this disease in the area covered )] TJ ET BT 26.250 181.769 Td /F1 9.8 Tf [(by the North East Metropolitan Regional Hospital Board. Brain. 1967;90:203-232.)] TJ ET BT 26.250 158.825 Td /F1 9.8 Tf [(33.)] TJ ET BT 45.502 158.825 Td /F1 9.8 Tf [(Oliver JE. Huntington s chorea in Northamptonshire. Br J Psychiatry. 1970;116:241-253.)] TJ ET BT 26.250 135.881 Td /F1 9.8 Tf [(34.)] TJ ET BT 45.502 135.881 Td /F1 9.8 Tf [(Mattsson B. Clinical, genetic and pharmacological studies in Huntington s chorea. UMEA University Medical )] TJ ET BT 26.250 120.437 Td /F1 9.8 Tf [(Dissertations 7. Sweden: UMEA:21-51; 1974.)] TJ ET BT 26.250 97.493 Td /F1 9.8 Tf [(35.)] TJ ET BT 45.502 97.493 Td /F1 9.8 Tf [(Stevens DL. Huntington s chorea: a demographic, genetic and clinical study. MD thesis, University of )] TJ ET BT 26.250 82.049 Td /F1 9.8 Tf [(London, pp. 1-338; 1976.)] TJ ET BT 26.250 59.105 Td /F1 9.8 Tf [(36.)] TJ ET BT 45.502 59.105 Td /F1 9.8 Tf [(Walker DA, Harper PS, Wells CEC, Tyler A, Davies K, Newcombe RG. Huntington's Chorea in South Wales A )] TJ ET Q q 15.000 40.572 577.500 736.428 re W n 0.271 0.267 0.267 rg BT 26.250 757.145 Td /F1 9.8 Tf [(15.)] TJ ET BT 45.502 757.145 Td /F1 9.8 Tf [(Rawlins M. Huntington s disease out of the closet? Lancet 2010;376:1372-3.)] TJ ET BT 26.250 734.201 Td /F1 9.8 Tf [(16.)] TJ ET BT 45.502 734.201 Td /F1 9.8 Tf [(Warby SC, Visscher H, Collins JA, Doty CN et al. HTT haplotypes contribute to differences in Huntington s )] TJ ET BT 26.250 718.757 Td /F1 9.8 Tf [(disease prevalence between Europe and Eas Asia Europ J Hum Genet 2011; 19:561-566.)] TJ ET BT 26.250 695.813 Td /F1 9.8 Tf [(17.)] TJ ET BT 45.502 695.813 Td /F1 9.8 Tf [(Hayden MR, MacGregor, JM, Beighton, PH. The prevalence of Huntington s Chorea in South Africa. S Afr Med )] TJ ET BT 26.250 680.369 Td /F1 9.8 Tf [(J 1980;58:193-6.)] TJ ET BT 26.250 657.425 Td /F1 9.8 Tf [(18.)] TJ ET BT 45.502 657.425 Td /F1 9.8 Tf [(Reed TE, Chandler JH, Hughes EM, Davidson RT. Huntington s Chorea in Michigan: Demography and )] TJ ET BT 26.250 641.981 Td /F1 9.8 Tf [(genetics. Am J Hum Genet 1958;10:201-25.)] TJ ET BT 26.250 619.037 Td /F1 9.8 Tf [(19.)] TJ ET BT 45.502 619.037 Td /F1 9.8 Tf [(Folstein SE, Chase GA, Wahl WE, McDonnell AM, Folstein, MF. Huntington disease in Maryland: clinical )] TJ ET BT 26.250 603.593 Td /F1 9.8 Tf [(aspects of racial variation. Am J Hum Genet 1987;41:168-79.)] TJ ET BT 26.250 580.649 Td /F1 9.8 Tf [(20.)] TJ ET BT 45.502 580.649 Td /F1 9.8 Tf [(Panse F. Die Erbchorea: Eine klinische-genetische studie. Samml Psychiatr Neurol Einzeldarst, 18. Leipzig: )] TJ ET BT 26.250 565.205 Td /F1 9.8 Tf [(Thieme; 1942.)] TJ ET BT 26.250 542.261 Td /F1 9.8 Tf [(21.)] TJ ET BT 45.502 542.261 Td /F1 9.8 Tf [(The World Bank. Country Classifications, 2012. Available from http://data.worldbank.org/about/country-)] TJ ET BT 26.250 526.817 Td /F1 9.8 Tf [(classifications.)] TJ ET BT 26.250 503.873 Td /F1 9.8 Tf [(22.)] TJ ET BT 45.502 503.873 Td /F1 9.8 Tf [(R Development Core Team \(2011\). R: A Language and Environment for Statistical Computing, R Foundation )] TJ ET BT 26.250 488.429 Td /F1 9.8 Tf [(for Statistical Computing, Vienna, Austria, ISBN 3-900051-07-0.)] TJ ET BT 26.250 465.485 Td /F1 9.8 Tf [(23.)] TJ ET BT 45.502 465.485 Td /F1 9.8 Tf [(Bell J. Nervous Diseases and Muscular Dystrophies. In: Fisher RA, Penrose S, eds. The Treasury of Human )] TJ ET BT 26.250 450.041 Td /F1 9.8 Tf [(Inheritance. Vol IV. Cambridge: Cambridge University Press, pp.1-69; 1948.)] TJ ET BT 26.250 427.097 Td /F1 9.8 Tf [(24.)] TJ ET BT 45.502 427.097 Td /F1 9.8 Tf [(Cameron D, Venters GA. Some problems in Huntington s chorea. Scott Med J. 1967;12\(4\):152-6.)] TJ ET BT 26.250 404.153 Td /F1 9.8 Tf [(25.)] TJ ET BT 45.502 404.153 Td /F1 9.8 Tf [(Bickford JAR, Ellison RM. The high incidence of Huntington s chorea in the Duchy of Cornwall. J Ment Sci. )] TJ ET BT 26.250 388.709 Td /F1 9.8 Tf [(1953;99\(415\):291-4.)] TJ ET BT 26.250 365.765 Td /F1 9.8 Tf [(26.)] TJ ET BT 45.502 365.765 Td /F1 9.8 Tf [(Pleydell MJ. Huntington s chorea in Northamptonshire. Br Med J. 1954;2\(4897\):1121-8.)] TJ ET BT 26.250 342.821 Td /F1 9.8 Tf [(27.)] TJ ET BT 45.502 342.821 Td /F1 9.8 Tf [(Pleydell MJ. Huntington s chorea in Northamptonshire. Br Med J. 1955;2\(4944\):889.)] TJ ET BT 26.250 319.877 Td /F1 9.8 Tf [(28.)] TJ ET BT 45.502 319.877 Td /F1 9.8 Tf [(Hayden MR, MacGregor JM, Saffer DS, Beighton PH. The high frequency of juvenile Huntington s chorea in )] TJ ET BT 26.250 304.433 Td /F1 9.8 Tf [(South Africa. J Med Genet. 1982;19\(2\):94-7.)] TJ ET BT 26.250 281.489 Td /F1 9.8 Tf [(29.)] TJ ET BT 45.502 281.489 Td /F1 9.8 Tf [(Davenport CB, Muncey, EB. Huntington s Chorea in relation to history and eugenics. Am J Insan. )] TJ ET BT 26.250 266.045 Td /F1 9.8 Tf [(1916;73:195-222.)] TJ ET BT 26.250 243.101 Td /F1 9.8 Tf [(30.)] TJ ET BT 45.502 243.101 Td /F1 9.8 Tf [(Spillane J, Phillips R. Huntington s Chorea in South Wales. Q J Med. 1937;6:403-423.)] TJ ET BT 26.250 220.157 Td /F1 9.8 Tf [(31.)] TJ ET BT 45.502 220.157 Td /F1 9.8 Tf [(Brothers CR. Huntington s Chorea in Victoria and Tasmania. J Neurol Sci. 1964;1:405-420.)] TJ ET BT 26.250 197.213 Td /F1 9.8 Tf [(32.)] TJ ET BT 45.502 197.213 Td /F1 9.8 Tf [(Heathfield KWG. Huntington s chorea: Investigation into the prevalence of this disease in the area covered )] TJ ET BT 26.250 181.769 Td /F1 9.8 Tf [(by the North East Metropolitan Regional Hospital Board. Brain. 1967;90:203-232.)] TJ ET BT 26.250 158.825 Td /F1 9.8 Tf [(33.)] TJ ET BT 45.502 158.825 Td /F1 9.8 Tf [(Oliver JE. Huntington s chorea in Northamptonshire. Br J Psychiatry. 1970;116:241-253.)] TJ ET BT 26.250 135.881 Td /F1 9.8 Tf [(34.)] TJ ET BT 45.502 135.881 Td /F1 9.8 Tf [(Mattsson B. Clinical, genetic and pharmacological studies in Huntington s chorea. UMEA University Medical )] TJ ET BT 26.250 120.437 Td /F1 9.8 Tf [(Dissertations 7. Sweden: UMEA:21-51; 1974.)] TJ ET BT 26.250 97.493 Td /F1 9.8 Tf [(35.)] TJ ET BT 45.502 97.493 Td /F1 9.8 Tf [(Stevens DL. Huntington s chorea: a demographic, genetic and clinical study. MD thesis, University of )] TJ ET BT 26.250 82.049 Td /F1 9.8 Tf [(London, pp. 1-338; 1976.)] TJ ET BT 26.250 59.105 Td /F1 9.8 Tf [(36.)] TJ ET BT 45.502 59.105 Td /F1 9.8 Tf [(Walker DA, Harper PS, Wells CEC, Tyler A, Davies K, Newcombe RG. Huntington's Chorea in South Wales A )] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 18.032 Td /F5 11.0 Tf [(17)] TJ ET BT 25.000 18.032 Td /F5 11.0 Tf [(PLOS Currents Huntington Disease)] TJ ET Q endstream endobj 875 0 obj << /Type /Page /Parent 3 0 R /Contents 876 0 R >> endobj 876 0 obj << /Length 25146 >> stream 0.271 0.267 0.267 rg q 15.000 40.128 577.500 736.872 re W n 0.271 0.267 0.267 rg BT 26.250 764.645 Td /F1 9.8 Tf [(genetic and epidemiological study. Clin Gen. 1981;19\(4\):213 221.)] TJ ET BT 26.250 741.701 Td /F1 9.8 Tf [(37.)] TJ ET BT 45.502 741.701 Td /F1 9.8 Tf [(Myers RH, Madden JJ, Teague JL, Falek A. Factors related to onset age of Huntington disease. Am J Hum )] TJ ET BT 26.250 726.257 Td /F1 9.8 Tf [(Genet. 1982;34\(3\):481-8.)] TJ ET BT 26.250 703.313 Td /F1 9.8 Tf [(38.)] TJ ET BT 45.502 703.313 Td /F1 9.8 Tf [(Went LN, Vegter-van der Vlis M, Bruyn LW, Vlkers WS. Huntington's chorea in the Netherlands - The problem )] TJ ET BT 26.250 687.869 Td /F1 9.8 Tf [(of genetic heterogeneity. Ann Hum Genet 1983;47\(3\):205-14)] TJ ET BT 26.250 664.925 Td /F1 9.8 Tf [(39.)] TJ ET BT 45.502 664.925 Td /F1 9.8 Tf [(Di Maio L, Mengano A, Maggio MA, Michele G De, Campanella G. Paternal and maternal transmission in )] TJ ET BT 26.250 649.481 Td /F1 9.8 Tf [(Huntington s disease. Acta Neurol. 1984;6\(6\):447-50.)] TJ ET BT 26.250 626.537 Td /F1 9.8 Tf [(40.)] TJ ET BT 45.502 626.537 Td /F1 9.8 Tf [(Went LN, Vegter-van der Vlis M, Bruyn GW. Parental transmission in Huntington s disease. Lancet. )] TJ ET BT 26.250 611.093 Td /F1 9.8 Tf [(1984;1\(8386\):1100-2.)] TJ ET BT 26.250 588.149 Td /F1 9.8 Tf [(41.)] TJ ET BT 45.502 588.149 Td /F1 9.8 Tf [(Farrer LA, Conneally PM. A genetic model for age at onset in Huntington disease. Am J Hum Genet. )] TJ ET BT 26.250 572.705 Td /F1 9.8 Tf [(1985;37\(2\):350-7.)] TJ ET BT 26.250 549.761 Td /F1 9.8 Tf [(42.)] TJ ET BT 45.502 549.761 Td /F1 9.8 Tf [(Hayden MR, Soles JA, Ward RH. Age of onset in siblings of persons with juvenile Huntington disease. Clin )] TJ ET BT 26.250 534.317 Td /F1 9.8 Tf [(Gen. 1985;28\(2\):100-5.)] TJ ET BT 26.250 511.373 Td /F1 9.8 Tf [(43.)] TJ ET BT 45.502 511.373 Td /F1 9.8 Tf [(Groppi C, Barontini F, Bracco L, et al. Huntington s chorea: a prevalence study in the Florence area. Acta )] TJ ET BT 26.250 495.929 Td /F1 9.8 Tf [(Neurol Scand. 1986;74\(4\):266-8.)] TJ ET BT 26.250 472.985 Td /F1 9.8 Tf [(44.)] TJ ET BT 45.502 472.985 Td /F1 9.8 Tf [(Young AB, Shoulson I, Penney JB, et al. Huntington s disease in Venezuela: neurologic features and )] TJ ET BT 26.250 457.541 Td /F1 9.8 Tf [(functional decline. Neurol. 1986;36\(2\):244-9.)] TJ ET BT 26.250 434.597 Td /F1 9.8 Tf [(45.)] TJ ET BT 45.502 434.597 Td /F1 9.8 Tf [(Adams P, Falek A, Arnold J. Huntington disease in Georgia: age at onset. Am J of Hum Genet. 1988;43\(5\):695-)] TJ ET BT 26.250 419.153 Td /F1 9.8 Tf [(704.)] TJ ET BT 26.250 396.209 Td /F1 9.8 Tf [(46.)] TJ ET BT 45.502 396.209 Td /F1 9.8 Tf [(Frontali M, Malaspina P, Rossi C, et al. Epidemiological and linkage studies on Huntington s disease in Italy. )] TJ ET BT 26.250 380.765 Td /F1 9.8 Tf [(Hum Genet. 1990;85\(2\):165-70.)] TJ ET BT 26.250 357.821 Td /F1 9.8 Tf [(47.)] TJ ET BT 45.502 357.821 Td /F1 9.8 Tf [( Pavoni M, Granieri E, Govoni V, et al. Epidemiologic approach to Huntington s disease in northern Italy )] TJ ET BT 26.250 342.377 Td /F1 9.8 Tf [(\(Ferrara area\). Neuroepidemiology. 1990;9\(6\):306-14.)] TJ ET BT 26.250 319.433 Td /F1 9.8 Tf [(48.)] TJ ET BT 45.502 319.433 Td /F1 9.8 Tf [(Pridmore SA. Age of onset of Huntington s disease in Tasmania. Med J Aust. 1990;153\(3\):135-7.)] TJ ET BT 26.250 296.489 Td /F1 9.8 Tf [(49.)] TJ ET BT 45.502 296.489 Td /F1 9.8 Tf [(Roos RA, Vegter-van der Vlis M, Hermans J, et al. Age at onset in Huntington s disease: effect of line of )] TJ ET BT 26.250 281.045 Td /F1 9.8 Tf [(inheritance and patient's sex. J Med Genet. 1991;28\(8\):515-9.)] TJ ET BT 26.250 258.101 Td /F1 9.8 Tf [(50.)] TJ ET BT 45.502 258.101 Td /F1 9.8 Tf [(Leung CM, Chan YW, Chang CM, Yu YL, Chen CN. Huntington s disease in Chinese: a hypothesis of its origin. )] TJ ET BT 26.250 242.657 Td /F1 9.8 Tf [(J Neurol, Neurosurg, and Psychiatry. 1992;55\(8\):681-4.)] TJ ET BT 26.250 219.713 Td /F1 9.8 Tf [(51.)] TJ ET BT 45.502 219.713 Td /F1 9.8 Tf [(Ridley RM, Farrer LA, Frith CD, Conneally PM. A test of the hypothesis that age at onset in Huntington )] TJ ET BT 26.250 204.269 Td /F1 9.8 Tf [(disease is controlled by an X-linked recessive modifier. Am J Hum Genet. 1992;50\(3\):536-43)] TJ ET BT 26.250 181.325 Td /F1 9.8 Tf [(52.)] TJ ET BT 45.502 181.325 Td /F1 9.8 Tf [(Morrison PJ, Nevin NC. Huntington disease in County Donegal: epidemiological trends over four decades. )] TJ ET BT 26.250 165.881 Td /F1 9.8 Tf [(Ulster Med J. 1993;62\(2\):141-4)] TJ ET BT 26.250 142.937 Td /F1 9.8 Tf [(53.)] TJ ET BT 45.502 142.937 Td /F1 9.8 Tf [(Roos RA, Hermans J, Vegter-van der Vlis M, Ommen GJ van, Bruyn GW. Duration of illness in Huntington s )] TJ ET BT 26.250 127.493 Td /F1 9.8 Tf [(disease is not related to age at onset. J Neurol Neurosurg Psychiatry. 1993;56\(1\):98-100.)] TJ ET BT 26.250 104.549 Td /F1 9.8 Tf [(54.)] TJ ET BT 45.502 104.549 Td /F1 9.8 Tf [(Simpson SA, Davidson MJ, Barron LH. Huntington s disease in Grampian region: correlation of the CAG )] TJ ET BT 26.250 89.105 Td /F1 9.8 Tf [(repeat number and the age of onset of the disease. J Med Genet. 1993;30\(12\):1014-7.)] TJ ET BT 26.250 66.161 Td /F1 9.8 Tf [(55.)] TJ ET BT 45.502 66.161 Td /F1 9.8 Tf [( Watt DC, Seller A. A clinico-genetic study of psychiatric disorder in Huntington s chorea. Psychol Med. )] TJ ET BT 26.250 50.717 Td /F1 9.8 Tf [(1993;Suppl 23:1-46.)] TJ ET Q q 15.000 40.128 577.500 736.872 re W n 0.271 0.267 0.267 rg BT 26.250 764.645 Td /F1 9.8 Tf [(genetic and epidemiological study. Clin Gen. 1981;19\(4\):213 221.)] TJ ET BT 26.250 741.701 Td /F1 9.8 Tf [(37.)] TJ ET BT 45.502 741.701 Td /F1 9.8 Tf [(Myers RH, Madden JJ, Teague JL, Falek A. Factors related to onset age of Huntington disease. Am J Hum )] TJ ET BT 26.250 726.257 Td /F1 9.8 Tf [(Genet. 1982;34\(3\):481-8.)] TJ ET BT 26.250 703.313 Td /F1 9.8 Tf [(38.)] TJ ET BT 45.502 703.313 Td /F1 9.8 Tf [(Went LN, Vegter-van der Vlis M, Bruyn LW, Vlkers WS. Huntington's chorea in the Netherlands - The problem )] TJ ET BT 26.250 687.869 Td /F1 9.8 Tf [(of genetic heterogeneity. Ann Hum Genet 1983;47\(3\):205-14)] TJ ET BT 26.250 664.925 Td /F1 9.8 Tf [(39.)] TJ ET BT 45.502 664.925 Td /F1 9.8 Tf [(Di Maio L, Mengano A, Maggio MA, Michele G De, Campanella G. Paternal and maternal transmission in )] TJ ET BT 26.250 649.481 Td /F1 9.8 Tf [(Huntington s disease. Acta Neurol. 1984;6\(6\):447-50.)] TJ ET BT 26.250 626.537 Td /F1 9.8 Tf [(40.)] TJ ET BT 45.502 626.537 Td /F1 9.8 Tf [(Went LN, Vegter-van der Vlis M, Bruyn GW. Parental transmission in Huntington s disease. Lancet. )] TJ ET BT 26.250 611.093 Td /F1 9.8 Tf [(1984;1\(8386\):1100-2.)] TJ ET BT 26.250 588.149 Td /F1 9.8 Tf [(41.)] TJ ET BT 45.502 588.149 Td /F1 9.8 Tf [(Farrer LA, Conneally PM. A genetic model for age at onset in Huntington disease. Am J Hum Genet. )] TJ ET BT 26.250 572.705 Td /F1 9.8 Tf [(1985;37\(2\):350-7.)] TJ ET BT 26.250 549.761 Td /F1 9.8 Tf [(42.)] TJ ET BT 45.502 549.761 Td /F1 9.8 Tf [(Hayden MR, Soles JA, Ward RH. Age of onset in siblings of persons with juvenile Huntington disease. Clin )] TJ ET BT 26.250 534.317 Td /F1 9.8 Tf [(Gen. 1985;28\(2\):100-5.)] TJ ET BT 26.250 511.373 Td /F1 9.8 Tf [(43.)] TJ ET BT 45.502 511.373 Td /F1 9.8 Tf [(Groppi C, Barontini F, Bracco L, et al. Huntington s chorea: a prevalence study in the Florence area. Acta )] TJ ET BT 26.250 495.929 Td /F1 9.8 Tf [(Neurol Scand. 1986;74\(4\):266-8.)] TJ ET BT 26.250 472.985 Td /F1 9.8 Tf [(44.)] TJ ET BT 45.502 472.985 Td /F1 9.8 Tf [(Young AB, Shoulson I, Penney JB, et al. Huntington s disease in Venezuela: neurologic features and )] TJ ET BT 26.250 457.541 Td /F1 9.8 Tf [(functional decline. Neurol. 1986;36\(2\):244-9.)] TJ ET BT 26.250 434.597 Td /F1 9.8 Tf [(45.)] TJ ET BT 45.502 434.597 Td /F1 9.8 Tf [(Adams P, Falek A, Arnold J. Huntington disease in Georgia: age at onset. Am J of Hum Genet. 1988;43\(5\):695-)] TJ ET BT 26.250 419.153 Td /F1 9.8 Tf [(704.)] TJ ET BT 26.250 396.209 Td /F1 9.8 Tf [(46.)] TJ ET BT 45.502 396.209 Td /F1 9.8 Tf [(Frontali M, Malaspina P, Rossi C, et al. Epidemiological and linkage studies on Huntington s disease in Italy. )] TJ ET BT 26.250 380.765 Td /F1 9.8 Tf [(Hum Genet. 1990;85\(2\):165-70.)] TJ ET BT 26.250 357.821 Td /F1 9.8 Tf [(47.)] TJ ET BT 45.502 357.821 Td /F1 9.8 Tf [( Pavoni M, Granieri E, Govoni V, et al. Epidemiologic approach to Huntington s disease in northern Italy )] TJ ET BT 26.250 342.377 Td /F1 9.8 Tf [(\(Ferrara area\). Neuroepidemiology. 1990;9\(6\):306-14.)] TJ ET BT 26.250 319.433 Td /F1 9.8 Tf [(48.)] TJ ET BT 45.502 319.433 Td /F1 9.8 Tf [(Pridmore SA. Age of onset of Huntington s disease in Tasmania. Med J Aust. 1990;153\(3\):135-7.)] TJ ET BT 26.250 296.489 Td /F1 9.8 Tf [(49.)] TJ ET BT 45.502 296.489 Td /F1 9.8 Tf [(Roos RA, Vegter-van der Vlis M, Hermans J, et al. Age at onset in Huntington s disease: effect of line of )] TJ ET BT 26.250 281.045 Td /F1 9.8 Tf [(inheritance and patient's sex. J Med Genet. 1991;28\(8\):515-9.)] TJ ET BT 26.250 258.101 Td /F1 9.8 Tf [(50.)] TJ ET BT 45.502 258.101 Td /F1 9.8 Tf [(Leung CM, Chan YW, Chang CM, Yu YL, Chen CN. Huntington s disease in Chinese: a hypothesis of its origin. )] TJ ET BT 26.250 242.657 Td /F1 9.8 Tf [(J Neurol, Neurosurg, and Psychiatry. 1992;55\(8\):681-4.)] TJ ET BT 26.250 219.713 Td /F1 9.8 Tf [(51.)] TJ ET BT 45.502 219.713 Td /F1 9.8 Tf [(Ridley RM, Farrer LA, Frith CD, Conneally PM. A test of the hypothesis that age at onset in Huntington )] TJ ET BT 26.250 204.269 Td /F1 9.8 Tf [(disease is controlled by an X-linked recessive modifier. Am J Hum Genet. 1992;50\(3\):536-43)] TJ ET BT 26.250 181.325 Td /F1 9.8 Tf [(52.)] TJ ET BT 45.502 181.325 Td /F1 9.8 Tf [(Morrison PJ, Nevin NC. Huntington disease in County Donegal: epidemiological trends over four decades. )] TJ ET BT 26.250 165.881 Td /F1 9.8 Tf [(Ulster Med J. 1993;62\(2\):141-4)] TJ ET BT 26.250 142.937 Td /F1 9.8 Tf [(53.)] TJ ET BT 45.502 142.937 Td /F1 9.8 Tf [(Roos RA, Hermans J, Vegter-van der Vlis M, Ommen GJ van, Bruyn GW. Duration of illness in Huntington s )] TJ ET BT 26.250 127.493 Td /F1 9.8 Tf [(disease is not related to age at onset. J Neurol Neurosurg Psychiatry. 1993;56\(1\):98-100.)] TJ ET BT 26.250 104.549 Td /F1 9.8 Tf [(54.)] TJ ET BT 45.502 104.549 Td /F1 9.8 Tf [(Simpson SA, Davidson MJ, Barron LH. Huntington s disease in Grampian region: correlation of the CAG )] TJ ET BT 26.250 89.105 Td /F1 9.8 Tf [(repeat number and the age of onset of the disease. J Med Genet. 1993;30\(12\):1014-7.)] TJ ET BT 26.250 66.161 Td /F1 9.8 Tf [(55.)] TJ ET BT 45.502 66.161 Td /F1 9.8 Tf [( Watt DC, Seller A. A clinico-genetic study of psychiatric disorder in Huntington s chorea. Psychol Med. )] TJ ET BT 26.250 50.717 Td /F1 9.8 Tf [(1993;Suppl 23:1-46.)] TJ ET Q q 15.000 40.128 577.500 736.872 re W n 0.271 0.267 0.267 rg BT 26.250 764.645 Td /F1 9.8 Tf [(genetic and epidemiological study. Clin Gen. 1981;19\(4\):213 221.)] TJ ET BT 26.250 741.701 Td /F1 9.8 Tf [(37.)] TJ ET BT 45.502 741.701 Td /F1 9.8 Tf [(Myers RH, Madden JJ, Teague JL, Falek A. Factors related to onset age of Huntington disease. Am J Hum )] TJ ET BT 26.250 726.257 Td /F1 9.8 Tf [(Genet. 1982;34\(3\):481-8.)] TJ ET BT 26.250 703.313 Td /F1 9.8 Tf [(38.)] TJ ET BT 45.502 703.313 Td /F1 9.8 Tf [(Went LN, Vegter-van der Vlis M, Bruyn LW, Vlkers WS. Huntington's chorea in the Netherlands - The problem )] TJ ET BT 26.250 687.869 Td /F1 9.8 Tf [(of genetic heterogeneity. Ann Hum Genet 1983;47\(3\):205-14)] TJ ET BT 26.250 664.925 Td /F1 9.8 Tf [(39.)] TJ ET BT 45.502 664.925 Td /F1 9.8 Tf [(Di Maio L, Mengano A, Maggio MA, Michele G De, Campanella G. Paternal and maternal transmission in )] TJ ET BT 26.250 649.481 Td /F1 9.8 Tf [(Huntington s disease. Acta Neurol. 1984;6\(6\):447-50.)] TJ ET BT 26.250 626.537 Td /F1 9.8 Tf [(40.)] TJ ET BT 45.502 626.537 Td /F1 9.8 Tf [(Went LN, Vegter-van der Vlis M, Bruyn GW. Parental transmission in Huntington s disease. Lancet. )] TJ ET BT 26.250 611.093 Td /F1 9.8 Tf [(1984;1\(8386\):1100-2.)] TJ ET BT 26.250 588.149 Td /F1 9.8 Tf [(41.)] TJ ET BT 45.502 588.149 Td /F1 9.8 Tf [(Farrer LA, Conneally PM. A genetic model for age at onset in Huntington disease. Am J Hum Genet. )] TJ ET BT 26.250 572.705 Td /F1 9.8 Tf [(1985;37\(2\):350-7.)] TJ ET BT 26.250 549.761 Td /F1 9.8 Tf [(42.)] TJ ET BT 45.502 549.761 Td /F1 9.8 Tf [(Hayden MR, Soles JA, Ward RH. Age of onset in siblings of persons with juvenile Huntington disease. Clin )] TJ ET BT 26.250 534.317 Td /F1 9.8 Tf [(Gen. 1985;28\(2\):100-5.)] TJ ET BT 26.250 511.373 Td /F1 9.8 Tf [(43.)] TJ ET BT 45.502 511.373 Td /F1 9.8 Tf [(Groppi C, Barontini F, Bracco L, et al. Huntington s chorea: a prevalence study in the Florence area. Acta )] TJ ET BT 26.250 495.929 Td /F1 9.8 Tf [(Neurol Scand. 1986;74\(4\):266-8.)] TJ ET BT 26.250 472.985 Td /F1 9.8 Tf [(44.)] TJ ET BT 45.502 472.985 Td /F1 9.8 Tf [(Young AB, Shoulson I, Penney JB, et al. Huntington s disease in Venezuela: neurologic features and )] TJ ET BT 26.250 457.541 Td /F1 9.8 Tf [(functional decline. Neurol. 1986;36\(2\):244-9.)] TJ ET BT 26.250 434.597 Td /F1 9.8 Tf [(45.)] TJ ET BT 45.502 434.597 Td /F1 9.8 Tf [(Adams P, Falek A, Arnold J. Huntington disease in Georgia: age at onset. Am J of Hum Genet. 1988;43\(5\):695-)] TJ ET BT 26.250 419.153 Td /F1 9.8 Tf [(704.)] TJ ET BT 26.250 396.209 Td /F1 9.8 Tf [(46.)] TJ ET BT 45.502 396.209 Td /F1 9.8 Tf [(Frontali M, Malaspina P, Rossi C, et al. Epidemiological and linkage studies on Huntington s disease in Italy. )] TJ ET BT 26.250 380.765 Td /F1 9.8 Tf [(Hum Genet. 1990;85\(2\):165-70.)] TJ ET BT 26.250 357.821 Td /F1 9.8 Tf [(47.)] TJ ET BT 45.502 357.821 Td /F1 9.8 Tf [( Pavoni M, Granieri E, Govoni V, et al. Epidemiologic approach to Huntington s disease in northern Italy )] TJ ET BT 26.250 342.377 Td /F1 9.8 Tf [(\(Ferrara area\). Neuroepidemiology. 1990;9\(6\):306-14.)] TJ ET BT 26.250 319.433 Td /F1 9.8 Tf [(48.)] TJ ET BT 45.502 319.433 Td /F1 9.8 Tf [(Pridmore SA. Age of onset of Huntington s disease in Tasmania. Med J Aust. 1990;153\(3\):135-7.)] TJ ET BT 26.250 296.489 Td /F1 9.8 Tf [(49.)] TJ ET BT 45.502 296.489 Td /F1 9.8 Tf [(Roos RA, Vegter-van der Vlis M, Hermans J, et al. Age at onset in Huntington s disease: effect of line of )] TJ ET BT 26.250 281.045 Td /F1 9.8 Tf [(inheritance and patient's sex. J Med Genet. 1991;28\(8\):515-9.)] TJ ET BT 26.250 258.101 Td /F1 9.8 Tf [(50.)] TJ ET BT 45.502 258.101 Td /F1 9.8 Tf [(Leung CM, Chan YW, Chang CM, Yu YL, Chen CN. Huntington s disease in Chinese: a hypothesis of its origin. )] TJ ET BT 26.250 242.657 Td /F1 9.8 Tf [(J Neurol, Neurosurg, and Psychiatry. 1992;55\(8\):681-4.)] TJ ET BT 26.250 219.713 Td /F1 9.8 Tf [(51.)] TJ ET BT 45.502 219.713 Td /F1 9.8 Tf [(Ridley RM, Farrer LA, Frith CD, Conneally PM. A test of the hypothesis that age at onset in Huntington )] TJ ET BT 26.250 204.269 Td /F1 9.8 Tf [(disease is controlled by an X-linked recessive modifier. Am J Hum Genet. 1992;50\(3\):536-43)] TJ ET BT 26.250 181.325 Td /F1 9.8 Tf [(52.)] TJ ET BT 45.502 181.325 Td /F1 9.8 Tf [(Morrison PJ, Nevin NC. Huntington disease in County Donegal: epidemiological trends over four decades. )] TJ ET BT 26.250 165.881 Td /F1 9.8 Tf [(Ulster Med J. 1993;62\(2\):141-4)] TJ ET BT 26.250 142.937 Td /F1 9.8 Tf [(53.)] TJ ET BT 45.502 142.937 Td /F1 9.8 Tf [(Roos RA, Hermans J, Vegter-van der Vlis M, Ommen GJ van, Bruyn GW. Duration of illness in Huntington s )] TJ ET BT 26.250 127.493 Td /F1 9.8 Tf [(disease is not related to age at onset. J Neurol Neurosurg Psychiatry. 1993;56\(1\):98-100.)] TJ ET BT 26.250 104.549 Td /F1 9.8 Tf [(54.)] TJ ET BT 45.502 104.549 Td /F1 9.8 Tf [(Simpson SA, Davidson MJ, Barron LH. Huntington s disease in Grampian region: correlation of the CAG )] TJ ET BT 26.250 89.105 Td /F1 9.8 Tf [(repeat number and the age of onset of the disease. J Med Genet. 1993;30\(12\):1014-7.)] TJ ET BT 26.250 66.161 Td /F1 9.8 Tf [(55.)] TJ ET BT 45.502 66.161 Td /F1 9.8 Tf [( Watt DC, Seller A. A clinico-genetic study of psychiatric disorder in Huntington s chorea. Psychol Med. )] TJ ET BT 26.250 50.717 Td /F1 9.8 Tf [(1993;Suppl 23:1-46.)] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 18.032 Td /F5 11.0 Tf [(18)] TJ ET BT 25.000 18.032 Td /F5 11.0 Tf [(PLOS Currents Huntington Disease)] TJ ET Q endstream endobj 877 0 obj << /Type /Page /Parent 3 0 R /Contents 878 0 R >> endobj 878 0 obj << /Length 26151 >> stream 0.271 0.267 0.267 rg q 15.000 32.184 577.500 744.816 re W n 0.271 0.267 0.267 rg BT 26.250 757.145 Td /F1 9.8 Tf [(56.)] TJ ET BT 45.502 757.145 Td /F1 9.8 Tf [(Shiwach RS. Prevalence of Huntington s disease in the Oxford region. Br J Psychiatry /: J Ment Sci. )] TJ ET BT 26.250 741.701 Td /F1 9.8 Tf [(1994;165\(3\):414-5.)] TJ ET BT 26.250 718.757 Td /F1 9.8 Tf [(57.)] TJ ET BT 45.502 718.757 Td /F1 9.8 Tf [(Morrison PJ, Johnston WP, Nevin NC. The epidemiology of Huntington s disease in Northern Ireland. J Med )] TJ ET BT 26.250 703.313 Td /F1 9.8 Tf [(Genet. 1995;32\(7\):524-30.)] TJ ET BT 26.250 680.369 Td /F1 9.8 Tf [(58.)] TJ ET BT 45.502 680.369 Td /F1 9.8 Tf [(Alonso ME, Yescas P, Cisneros B, et al. Analysis of the \(CAG\)n repeat causing Huntington s disease in a )] TJ ET BT 26.250 664.925 Td /F1 9.8 Tf [(Mexican population. Clin Gen. 1997;51\(4\):225-30.)] TJ ET BT 26.250 641.981 Td /F1 9.8 Tf [(59.)] TJ ET BT 45.502 641.981 Td /F1 9.8 Tf [( Gmez-Tortosa E, Barrio A del, Garca Ruiz PJ, et al. Severity of cognitive impairment in juvenile and late-)] TJ ET BT 26.250 626.537 Td /F1 9.8 Tf [(onset Huntington disease. Arch Neurol. 1998;55\(6\):835-43)] TJ ET BT 26.250 603.593 Td /F1 9.8 Tf [(60.)] TJ ET BT 45.502 603.593 Td /F1 9.8 Tf [(Ata FB, Elibol B, Schaefer F. The genetic analysis of Turkish patients with Huntington s disease. Acta Neurol )] TJ ET BT 26.250 588.149 Td /F1 9.8 Tf [(Scand. 1999;100\(3\):195-8.)] TJ ET BT 26.250 565.205 Td /F1 9.8 Tf [(61.)] TJ ET BT 45.502 565.205 Td /F1 9.8 Tf [(Foroud T, Gray J, Ivashina J, Conneally PM. Differences in duration of Huntington s disease based on age at )] TJ ET BT 26.250 549.761 Td /F1 9.8 Tf [(onset. J Neurol Neurosurg Psychiatry. 1999;66\(1\):52-6)] TJ ET BT 26.250 526.817 Td /F1 9.8 Tf [(62.)] TJ ET BT 45.502 526.817 Td /F1 9.8 Tf [(Louis ED, Lee P, Quinn L, Marder K. Dystonia in Huntington s disease: prevalence and clinical characteristics. )] TJ ET BT 26.250 511.373 Td /F1 9.8 Tf [(Mov Disord. 1999;14\(1\):95-101.)] TJ ET BT 26.250 488.429 Td /F1 9.8 Tf [(63.)] TJ ET BT 45.502 488.429 Td /F1 9.8 Tf [( Lima E Silva TC, Serra HG, Bertuzzo CS, Lopes-Cendes I. Molecular diagnosis of Huntington disease in )] TJ ET BT 26.250 472.985 Td /F1 9.8 Tf [(Brazilian patients. Arq Neuropsiquiatr. 2000;58\(1\):11-7.)] TJ ET BT 26.250 450.041 Td /F1 9.8 Tf [(64.)] TJ ET BT 45.502 450.041 Td /F1 9.8 Tf [(Raskin S, Allan N, Teive HA, et al. Huntington disease: DNA analysis in Brazilian population. Arq )] TJ ET BT 26.250 434.597 Td /F1 9.8 Tf [(Neuropsiquiatr. 2000;58\(4\):977-85.)] TJ ET BT 26.250 411.653 Td /F1 9.8 Tf [(65.)] TJ ET BT 45.502 411.653 Td /F1 9.8 Tf [(Rasmussen A, Macias R, Yescas P, et al. Huntington disease in children: genotype-phenotype correlation. )] TJ ET BT 26.250 396.209 Td /F1 9.8 Tf [(Neuropediatrics. 2000;31\(4\):190-4.)] TJ ET BT 26.250 373.265 Td /F1 9.8 Tf [(66.)] TJ ET BT 45.502 373.265 Td /F1 9.8 Tf [(Almqvist EW, Elterman DS, MacLeod PM, Hayden MR. High incidence rate and absent family histories in one )] TJ ET BT 26.250 357.821 Td /F1 9.8 Tf [(quarter of patients newly diagnosed with Huntington disease in British Columbia. Clin Gen. 2001;60\(3\):198-205.)] TJ ET BT 26.250 334.877 Td /F1 9.8 Tf [(67.)] TJ ET BT 45.502 334.877 Td /F1 9.8 Tf [( Murgod UA, Saleem Q, Anand A, et al. A clinical study of patients with genetically confirmed Huntington s )] TJ ET BT 26.250 319.433 Td /F1 9.8 Tf [(disease from India. J Neurol Sci. 2001;190\(1-2\):73-8.)] TJ ET BT 26.250 296.489 Td /F1 9.8 Tf [(68.)] TJ ET BT 45.502 296.489 Td /F1 9.8 Tf [(Maat-Kievit A, Losekoot M, Zwinderman K, et al. Predictability of age at onset in Huntington disease in the )] TJ ET BT 26.250 281.045 Td /F1 9.8 Tf [(Dutch population. Medicine. 2002;81\(4\):251-9.)] TJ ET BT 26.250 258.101 Td /F1 9.8 Tf [(69.)] TJ ET BT 45.502 258.101 Td /F1 9.8 Tf [(Akbas F, Erginel-Unaltuna N. DNA testing for Huntington disease in the Turkish population. Eur Neurol. )] TJ ET BT 26.250 242.657 Td /F1 9.8 Tf [(2003;50\(1\):20-4.)] TJ ET BT 26.250 219.713 Td /F1 9.8 Tf [(70.)] TJ ET BT 45.502 219.713 Td /F1 9.8 Tf [(Creighton S, Almqvist EW, MacGregor D, et al. Predictive, pre-natal and diagnostic genetic testing for )] TJ ET BT 26.250 204.269 Td /F1 9.8 Tf [(Huntington s disease: the experience in Canada from 1987)] TJ ET BT 26.250 181.325 Td /F1 9.8 Tf [(71.)] TJ ET BT 45.502 181.325 Td /F1 9.8 Tf [(do Camo Costa M, Magalhes P, Ferreirinha F, et al. Molecular diagnosis of Huntington disease in Portugal: )] TJ ET BT 26.250 165.881 Td /F1 9.8 Tf [(implications for genetic counselling and clinical practice. Eur J Hum Genet:2003;11\(11\):872-8.)] TJ ET BT 26.250 142.937 Td /F1 9.8 Tf [(72.)] TJ ET BT 45.502 142.937 Td /F1 9.8 Tf [(Cannella M, Gellera C, Maglione V, et al. The gender effect in juvenile Huntington disease patients of Italian )] TJ ET BT 26.250 127.493 Td /F1 9.8 Tf [(origin. American journal of medical genetics. Part B, Am J Med Genet B Neuropsychiatr Genet. 2004;125B\(1\):92-)] TJ ET BT 26.250 112.049 Td /F1 9.8 Tf [(8.)] TJ ET BT 26.250 89.105 Td /F1 9.8 Tf [(73.)] TJ ET BT 45.502 89.105 Td /F1 9.8 Tf [(Ramos-Arroyo MA, Moreno S, Valiente A. Incidence and mutation rates of Huntington s disease in Spain: )] TJ ET BT 26.250 73.661 Td /F1 9.8 Tf [(experience of 9 years of direct genetic testing. J Neurol Neurosurg Psychiatry. 2005;76\(3\):337-42.)] TJ ET BT 26.250 50.717 Td /F1 9.8 Tf [(74.)] TJ ET BT 45.502 50.717 Td /F1 9.8 Tf [(Ruocco HH, Lopes-Cendes I, Laurito TL, Li LM, Cendes F. Clinical presentation of juvenile Huntington disease. )] TJ ET Q q 15.000 32.184 577.500 744.816 re W n 0.271 0.267 0.267 rg BT 26.250 757.145 Td /F1 9.8 Tf [(56.)] TJ ET BT 45.502 757.145 Td /F1 9.8 Tf [(Shiwach RS. Prevalence of Huntington s disease in the Oxford region. Br J Psychiatry /: J Ment Sci. )] TJ ET BT 26.250 741.701 Td /F1 9.8 Tf [(1994;165\(3\):414-5.)] TJ ET BT 26.250 718.757 Td /F1 9.8 Tf [(57.)] TJ ET BT 45.502 718.757 Td /F1 9.8 Tf [(Morrison PJ, Johnston WP, Nevin NC. The epidemiology of Huntington s disease in Northern Ireland. J Med )] TJ ET BT 26.250 703.313 Td /F1 9.8 Tf [(Genet. 1995;32\(7\):524-30.)] TJ ET BT 26.250 680.369 Td /F1 9.8 Tf [(58.)] TJ ET BT 45.502 680.369 Td /F1 9.8 Tf [(Alonso ME, Yescas P, Cisneros B, et al. Analysis of the \(CAG\)n repeat causing Huntington s disease in a )] TJ ET BT 26.250 664.925 Td /F1 9.8 Tf [(Mexican population. Clin Gen. 1997;51\(4\):225-30.)] TJ ET BT 26.250 641.981 Td /F1 9.8 Tf [(59.)] TJ ET BT 45.502 641.981 Td /F1 9.8 Tf [( Gmez-Tortosa E, Barrio A del, Garca Ruiz PJ, et al. Severity of cognitive impairment in juvenile and late-)] TJ ET BT 26.250 626.537 Td /F1 9.8 Tf [(onset Huntington disease. Arch Neurol. 1998;55\(6\):835-43)] TJ ET BT 26.250 603.593 Td /F1 9.8 Tf [(60.)] TJ ET BT 45.502 603.593 Td /F1 9.8 Tf [(Ata FB, Elibol B, Schaefer F. The genetic analysis of Turkish patients with Huntington s disease. Acta Neurol )] TJ ET BT 26.250 588.149 Td /F1 9.8 Tf [(Scand. 1999;100\(3\):195-8.)] TJ ET BT 26.250 565.205 Td /F1 9.8 Tf [(61.)] TJ ET BT 45.502 565.205 Td /F1 9.8 Tf [(Foroud T, Gray J, Ivashina J, Conneally PM. Differences in duration of Huntington s disease based on age at )] TJ ET BT 26.250 549.761 Td /F1 9.8 Tf [(onset. J Neurol Neurosurg Psychiatry. 1999;66\(1\):52-6)] TJ ET BT 26.250 526.817 Td /F1 9.8 Tf [(62.)] TJ ET BT 45.502 526.817 Td /F1 9.8 Tf [(Louis ED, Lee P, Quinn L, Marder K. Dystonia in Huntington s disease: prevalence and clinical characteristics. )] TJ ET BT 26.250 511.373 Td /F1 9.8 Tf [(Mov Disord. 1999;14\(1\):95-101.)] TJ ET BT 26.250 488.429 Td /F1 9.8 Tf [(63.)] TJ ET BT 45.502 488.429 Td /F1 9.8 Tf [( Lima E Silva TC, Serra HG, Bertuzzo CS, Lopes-Cendes I. Molecular diagnosis of Huntington disease in )] TJ ET BT 26.250 472.985 Td /F1 9.8 Tf [(Brazilian patients. Arq Neuropsiquiatr. 2000;58\(1\):11-7.)] TJ ET BT 26.250 450.041 Td /F1 9.8 Tf [(64.)] TJ ET BT 45.502 450.041 Td /F1 9.8 Tf [(Raskin S, Allan N, Teive HA, et al. Huntington disease: DNA analysis in Brazilian population. Arq )] TJ ET BT 26.250 434.597 Td /F1 9.8 Tf [(Neuropsiquiatr. 2000;58\(4\):977-85.)] TJ ET BT 26.250 411.653 Td /F1 9.8 Tf [(65.)] TJ ET BT 45.502 411.653 Td /F1 9.8 Tf [(Rasmussen A, Macias R, Yescas P, et al. Huntington disease in children: genotype-phenotype correlation. )] TJ ET BT 26.250 396.209 Td /F1 9.8 Tf [(Neuropediatrics. 2000;31\(4\):190-4.)] TJ ET BT 26.250 373.265 Td /F1 9.8 Tf [(66.)] TJ ET BT 45.502 373.265 Td /F1 9.8 Tf [(Almqvist EW, Elterman DS, MacLeod PM, Hayden MR. High incidence rate and absent family histories in one )] TJ ET BT 26.250 357.821 Td /F1 9.8 Tf [(quarter of patients newly diagnosed with Huntington disease in British Columbia. Clin Gen. 2001;60\(3\):198-205.)] TJ ET BT 26.250 334.877 Td /F1 9.8 Tf [(67.)] TJ ET BT 45.502 334.877 Td /F1 9.8 Tf [( Murgod UA, Saleem Q, Anand A, et al. A clinical study of patients with genetically confirmed Huntington s )] TJ ET BT 26.250 319.433 Td /F1 9.8 Tf [(disease from India. J Neurol Sci. 2001;190\(1-2\):73-8.)] TJ ET BT 26.250 296.489 Td /F1 9.8 Tf [(68.)] TJ ET BT 45.502 296.489 Td /F1 9.8 Tf [(Maat-Kievit A, Losekoot M, Zwinderman K, et al. Predictability of age at onset in Huntington disease in the )] TJ ET BT 26.250 281.045 Td /F1 9.8 Tf [(Dutch population. Medicine. 2002;81\(4\):251-9.)] TJ ET BT 26.250 258.101 Td /F1 9.8 Tf [(69.)] TJ ET BT 45.502 258.101 Td /F1 9.8 Tf [(Akbas F, Erginel-Unaltuna N. DNA testing for Huntington disease in the Turkish population. Eur Neurol. )] TJ ET BT 26.250 242.657 Td /F1 9.8 Tf [(2003;50\(1\):20-4.)] TJ ET BT 26.250 219.713 Td /F1 9.8 Tf [(70.)] TJ ET BT 45.502 219.713 Td /F1 9.8 Tf [(Creighton S, Almqvist EW, MacGregor D, et al. Predictive, pre-natal and diagnostic genetic testing for )] TJ ET BT 26.250 204.269 Td /F1 9.8 Tf [(Huntington s disease: the experience in Canada from 1987)] TJ ET BT 26.250 181.325 Td /F1 9.8 Tf [(71.)] TJ ET BT 45.502 181.325 Td /F1 9.8 Tf [(do Camo Costa M, Magalhes P, Ferreirinha F, et al. Molecular diagnosis of Huntington disease in Portugal: )] TJ ET BT 26.250 165.881 Td /F1 9.8 Tf [(implications for genetic counselling and clinical practice. Eur J Hum Genet:2003;11\(11\):872-8.)] TJ ET BT 26.250 142.937 Td /F1 9.8 Tf [(72.)] TJ ET BT 45.502 142.937 Td /F1 9.8 Tf [(Cannella M, Gellera C, Maglione V, et al. The gender effect in juvenile Huntington disease patients of Italian )] TJ ET BT 26.250 127.493 Td /F1 9.8 Tf [(origin. American journal of medical genetics. Part B, Am J Med Genet B Neuropsychiatr Genet. 2004;125B\(1\):92-)] TJ ET BT 26.250 112.049 Td /F1 9.8 Tf [(8.)] TJ ET BT 26.250 89.105 Td /F1 9.8 Tf [(73.)] TJ ET BT 45.502 89.105 Td /F1 9.8 Tf [(Ramos-Arroyo MA, Moreno S, Valiente A. Incidence and mutation rates of Huntington s disease in Spain: )] TJ ET BT 26.250 73.661 Td /F1 9.8 Tf [(experience of 9 years of direct genetic testing. J Neurol Neurosurg Psychiatry. 2005;76\(3\):337-42.)] TJ ET BT 26.250 50.717 Td /F1 9.8 Tf [(74.)] TJ ET BT 45.502 50.717 Td /F1 9.8 Tf [(Ruocco HH, Lopes-Cendes I, Laurito TL, Li LM, Cendes F. Clinical presentation of juvenile Huntington disease. )] TJ ET Q q 15.000 32.184 577.500 744.816 re W n 0.271 0.267 0.267 rg BT 26.250 757.145 Td /F1 9.8 Tf [(56.)] TJ ET BT 45.502 757.145 Td /F1 9.8 Tf [(Shiwach RS. Prevalence of Huntington s disease in the Oxford region. Br J Psychiatry /: J Ment Sci. )] TJ ET BT 26.250 741.701 Td /F1 9.8 Tf [(1994;165\(3\):414-5.)] TJ ET BT 26.250 718.757 Td /F1 9.8 Tf [(57.)] TJ ET BT 45.502 718.757 Td /F1 9.8 Tf [(Morrison PJ, Johnston WP, Nevin NC. The epidemiology of Huntington s disease in Northern Ireland. J Med )] TJ ET BT 26.250 703.313 Td /F1 9.8 Tf [(Genet. 1995;32\(7\):524-30.)] TJ ET BT 26.250 680.369 Td /F1 9.8 Tf [(58.)] TJ ET BT 45.502 680.369 Td /F1 9.8 Tf [(Alonso ME, Yescas P, Cisneros B, et al. Analysis of the \(CAG\)n repeat causing Huntington s disease in a )] TJ ET BT 26.250 664.925 Td /F1 9.8 Tf [(Mexican population. Clin Gen. 1997;51\(4\):225-30.)] TJ ET BT 26.250 641.981 Td /F1 9.8 Tf [(59.)] TJ ET BT 45.502 641.981 Td /F1 9.8 Tf [( Gmez-Tortosa E, Barrio A del, Garca Ruiz PJ, et al. Severity of cognitive impairment in juvenile and late-)] TJ ET BT 26.250 626.537 Td /F1 9.8 Tf [(onset Huntington disease. Arch Neurol. 1998;55\(6\):835-43)] TJ ET BT 26.250 603.593 Td /F1 9.8 Tf [(60.)] TJ ET BT 45.502 603.593 Td /F1 9.8 Tf [(Ata FB, Elibol B, Schaefer F. The genetic analysis of Turkish patients with Huntington s disease. Acta Neurol )] TJ ET BT 26.250 588.149 Td /F1 9.8 Tf [(Scand. 1999;100\(3\):195-8.)] TJ ET BT 26.250 565.205 Td /F1 9.8 Tf [(61.)] TJ ET BT 45.502 565.205 Td /F1 9.8 Tf [(Foroud T, Gray J, Ivashina J, Conneally PM. Differences in duration of Huntington s disease based on age at )] TJ ET BT 26.250 549.761 Td /F1 9.8 Tf [(onset. J Neurol Neurosurg Psychiatry. 1999;66\(1\):52-6)] TJ ET BT 26.250 526.817 Td /F1 9.8 Tf [(62.)] TJ ET BT 45.502 526.817 Td /F1 9.8 Tf [(Louis ED, Lee P, Quinn L, Marder K. Dystonia in Huntington s disease: prevalence and clinical characteristics. )] TJ ET BT 26.250 511.373 Td /F1 9.8 Tf [(Mov Disord. 1999;14\(1\):95-101.)] TJ ET BT 26.250 488.429 Td /F1 9.8 Tf [(63.)] TJ ET BT 45.502 488.429 Td /F1 9.8 Tf [( Lima E Silva TC, Serra HG, Bertuzzo CS, Lopes-Cendes I. Molecular diagnosis of Huntington disease in )] TJ ET BT 26.250 472.985 Td /F1 9.8 Tf [(Brazilian patients. Arq Neuropsiquiatr. 2000;58\(1\):11-7.)] TJ ET BT 26.250 450.041 Td /F1 9.8 Tf [(64.)] TJ ET BT 45.502 450.041 Td /F1 9.8 Tf [(Raskin S, Allan N, Teive HA, et al. Huntington disease: DNA analysis in Brazilian population. Arq )] TJ ET BT 26.250 434.597 Td /F1 9.8 Tf [(Neuropsiquiatr. 2000;58\(4\):977-85.)] TJ ET BT 26.250 411.653 Td /F1 9.8 Tf [(65.)] TJ ET BT 45.502 411.653 Td /F1 9.8 Tf [(Rasmussen A, Macias R, Yescas P, et al. Huntington disease in children: genotype-phenotype correlation. )] TJ ET BT 26.250 396.209 Td /F1 9.8 Tf [(Neuropediatrics. 2000;31\(4\):190-4.)] TJ ET BT 26.250 373.265 Td /F1 9.8 Tf [(66.)] TJ ET BT 45.502 373.265 Td /F1 9.8 Tf [(Almqvist EW, Elterman DS, MacLeod PM, Hayden MR. High incidence rate and absent family histories in one )] TJ ET BT 26.250 357.821 Td /F1 9.8 Tf [(quarter of patients newly diagnosed with Huntington disease in British Columbia. Clin Gen. 2001;60\(3\):198-205.)] TJ ET BT 26.250 334.877 Td /F1 9.8 Tf [(67.)] TJ ET BT 45.502 334.877 Td /F1 9.8 Tf [( Murgod UA, Saleem Q, Anand A, et al. A clinical study of patients with genetically confirmed Huntington s )] TJ ET BT 26.250 319.433 Td /F1 9.8 Tf [(disease from India. J Neurol Sci. 2001;190\(1-2\):73-8.)] TJ ET BT 26.250 296.489 Td /F1 9.8 Tf [(68.)] TJ ET BT 45.502 296.489 Td /F1 9.8 Tf [(Maat-Kievit A, Losekoot M, Zwinderman K, et al. Predictability of age at onset in Huntington disease in the )] TJ ET BT 26.250 281.045 Td /F1 9.8 Tf [(Dutch population. Medicine. 2002;81\(4\):251-9.)] TJ ET BT 26.250 258.101 Td /F1 9.8 Tf [(69.)] TJ ET BT 45.502 258.101 Td /F1 9.8 Tf [(Akbas F, Erginel-Unaltuna N. DNA testing for Huntington disease in the Turkish population. Eur Neurol. )] TJ ET BT 26.250 242.657 Td /F1 9.8 Tf [(2003;50\(1\):20-4.)] TJ ET BT 26.250 219.713 Td /F1 9.8 Tf [(70.)] TJ ET BT 45.502 219.713 Td /F1 9.8 Tf [(Creighton S, Almqvist EW, MacGregor D, et al. Predictive, pre-natal and diagnostic genetic testing for )] TJ ET BT 26.250 204.269 Td /F1 9.8 Tf [(Huntington s disease: the experience in Canada from 1987)] TJ ET BT 26.250 181.325 Td /F1 9.8 Tf [(71.)] TJ ET BT 45.502 181.325 Td /F1 9.8 Tf [(do Camo Costa M, Magalhes P, Ferreirinha F, et al. Molecular diagnosis of Huntington disease in Portugal: )] TJ ET BT 26.250 165.881 Td /F1 9.8 Tf [(implications for genetic counselling and clinical practice. Eur J Hum Genet:2003;11\(11\):872-8.)] TJ ET BT 26.250 142.937 Td /F1 9.8 Tf [(72.)] TJ ET BT 45.502 142.937 Td /F1 9.8 Tf [(Cannella M, Gellera C, Maglione V, et al. The gender effect in juvenile Huntington disease patients of Italian )] TJ ET BT 26.250 127.493 Td /F1 9.8 Tf [(origin. American journal of medical genetics. Part B, Am J Med Genet B Neuropsychiatr Genet. 2004;125B\(1\):92-)] TJ ET BT 26.250 112.049 Td /F1 9.8 Tf [(8.)] TJ ET BT 26.250 89.105 Td /F1 9.8 Tf [(73.)] TJ ET BT 45.502 89.105 Td /F1 9.8 Tf [(Ramos-Arroyo MA, Moreno S, Valiente A. Incidence and mutation rates of Huntington s disease in Spain: )] TJ ET BT 26.250 73.661 Td /F1 9.8 Tf [(experience of 9 years of direct genetic testing. J Neurol Neurosurg Psychiatry. 2005;76\(3\):337-42.)] TJ ET BT 26.250 50.717 Td /F1 9.8 Tf [(74.)] TJ ET BT 45.502 50.717 Td /F1 9.8 Tf [(Ruocco HH, Lopes-Cendes I, Laurito TL, Li LM, Cendes F. Clinical presentation of juvenile Huntington disease. )] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 18.032 Td /F5 11.0 Tf [(19)] TJ ET BT 25.000 18.032 Td /F5 11.0 Tf [(PLOS Currents Huntington Disease)] TJ ET Q endstream endobj 879 0 obj << /Type /Page /Parent 3 0 R /Contents 880 0 R >> endobj 880 0 obj << /Length 10173 >> stream 0.271 0.267 0.267 rg q 15.000 485.340 577.500 291.660 re W n 0.271 0.267 0.267 rg BT 26.250 764.645 Td /F1 9.8 Tf [(Arq Neuropsiquiatr 2006;64\(1\):5-9)] TJ ET BT 26.250 741.701 Td /F1 9.8 Tf [(75.)] TJ ET BT 45.502 741.701 Td /F1 9.8 Tf [(}idovsk J, KlempY J, Kebrdlov V, et al. Huntington s Disease: Experience with Genetic Testing within )] TJ ET BT 26.250 726.257 Td /F1 9.8 Tf [(1994 2005. Cesk Slov Neurol N 2007; 70/103\(1\): 72 77)] TJ ET BT 26.250 703.313 Td /F1 9.8 Tf [(76.)] TJ ET BT 45.502 703.313 Td /F1 9.8 Tf [(van Duijn E, Kingma EM, Timman R, et al. Cross-sectional study on prevalences of psychiatric disorders in )] TJ ET BT 26.250 687.869 Td /F1 9.8 Tf [(mutation carriers of Huntington s disease compared with mutation-negative first-degree relatives. J Clin )] TJ ET BT 26.250 672.425 Td /F1 9.8 Tf [(Psychiatry. 2008;69\(11\):1804-10.)] TJ ET BT 26.250 649.481 Td /F1 9.8 Tf [(77.)] TJ ET BT 45.502 649.481 Td /F1 9.8 Tf [(Alonso ME, Ochoa A, Boll M-C, et al. Clinical and genetic characteristics of Mexican Huntington s disease )] TJ ET BT 26.250 634.037 Td /F1 9.8 Tf [(patients. Movement. 2009;24\(13\):2012-5)] TJ ET BT 26.250 611.093 Td /F1 9.8 Tf [(78.)] TJ ET BT 45.502 611.093 Td /F1 9.8 Tf [(Torres G, Timana C, Cornejo M, et al. Molecular diagnosis of Huntington s disease in Peruvian population. )] TJ ET BT 26.250 595.649 Td /F1 9.8 Tf [(Mov Disord. 2010;25\(Suppl. 2\):S278)] TJ ET BT 26.250 572.705 Td /F1 9.8 Tf [(79.)] TJ ET BT 45.502 572.705 Td /F1 9.8 Tf [(Office for National Statistics. Annual Mid-year Population Estimates, 2010. Available at: )] TJ ET BT 26.250 557.261 Td /F1 9.8 Tf [(http://www.ons.gov.uk/ons/taxonomy/index.html?nscl=Population+Estimates. Accessed September 16, 2011.)] TJ ET BT 26.250 534.317 Td /F1 9.8 Tf [(80.)] TJ ET BT 45.502 534.317 Td /F1 9.8 Tf [(Gusella JF , Wexler NS, Conneally PM, Naylor SL, Anderson MA, Tanzi RE, Watkins PC, Ottina K, Wallace MR, )] TJ ET BT 26.250 518.873 Td /F1 9.8 Tf [(Sakaguchi AY \( 1983\) A polymorphic DNA marker genetically linked to Huntington s disease . Nature.1983 Nov )] TJ ET BT 26.250 503.429 Td /F1 9.8 Tf [(17-23; 306\(5940\):234-8.)] TJ ET Q q 15.000 485.340 577.500 291.660 re W n 0.271 0.267 0.267 rg BT 26.250 764.645 Td /F1 9.8 Tf [(Arq Neuropsiquiatr 2006;64\(1\):5-9)] TJ ET BT 26.250 741.701 Td /F1 9.8 Tf [(75.)] TJ ET BT 45.502 741.701 Td /F1 9.8 Tf [(}idovsk J, KlempY J, Kebrdlov V, et al. Huntington s Disease: Experience with Genetic Testing within )] TJ ET BT 26.250 726.257 Td /F1 9.8 Tf [(1994 2005. Cesk Slov Neurol N 2007; 70/103\(1\): 72 77)] TJ ET BT 26.250 703.313 Td /F1 9.8 Tf [(76.)] TJ ET BT 45.502 703.313 Td /F1 9.8 Tf [(van Duijn E, Kingma EM, Timman R, et al. Cross-sectional study on prevalences of psychiatric disorders in )] TJ ET BT 26.250 687.869 Td /F1 9.8 Tf [(mutation carriers of Huntington s disease compared with mutation-negative first-degree relatives. J Clin )] TJ ET BT 26.250 672.425 Td /F1 9.8 Tf [(Psychiatry. 2008;69\(11\):1804-10.)] TJ ET BT 26.250 649.481 Td /F1 9.8 Tf [(77.)] TJ ET BT 45.502 649.481 Td /F1 9.8 Tf [(Alonso ME, Ochoa A, Boll M-C, et al. Clinical and genetic characteristics of Mexican Huntington s disease )] TJ ET BT 26.250 634.037 Td /F1 9.8 Tf [(patients. Movement. 2009;24\(13\):2012-5)] TJ ET BT 26.250 611.093 Td /F1 9.8 Tf [(78.)] TJ ET BT 45.502 611.093 Td /F1 9.8 Tf [(Torres G, Timana C, Cornejo M, et al. Molecular diagnosis of Huntington s disease in Peruvian population. )] TJ ET BT 26.250 595.649 Td /F1 9.8 Tf [(Mov Disord. 2010;25\(Suppl. 2\):S278)] TJ ET BT 26.250 572.705 Td /F1 9.8 Tf [(79.)] TJ ET BT 45.502 572.705 Td /F1 9.8 Tf [(Office for National Statistics. Annual Mid-year Population Estimates, 2010. Available at: )] TJ ET BT 26.250 557.261 Td /F1 9.8 Tf [(http://www.ons.gov.uk/ons/taxonomy/index.html?nscl=Population+Estimates. Accessed September 16, 2011.)] TJ ET BT 26.250 534.317 Td /F1 9.8 Tf [(80.)] TJ ET BT 45.502 534.317 Td /F1 9.8 Tf [(Gusella JF , Wexler NS, Conneally PM, Naylor SL, Anderson MA, Tanzi RE, Watkins PC, Ottina K, Wallace MR, )] TJ ET BT 26.250 518.873 Td /F1 9.8 Tf [(Sakaguchi AY \( 1983\) A polymorphic DNA marker genetically linked to Huntington s disease . Nature.1983 Nov )] TJ ET BT 26.250 503.429 Td /F1 9.8 Tf [(17-23; 306\(5940\):234-8.)] TJ ET Q q 15.000 485.340 577.500 291.660 re W n 0.271 0.267 0.267 rg BT 26.250 764.645 Td /F1 9.8 Tf [(Arq Neuropsiquiatr 2006;64\(1\):5-9)] TJ ET BT 26.250 741.701 Td /F1 9.8 Tf [(75.)] TJ ET BT 45.502 741.701 Td /F1 9.8 Tf [(}idovsk J, KlempY J, Kebrdlov V, et al. Huntington s Disease: Experience with Genetic Testing within )] TJ ET BT 26.250 726.257 Td /F1 9.8 Tf [(1994 2005. Cesk Slov Neurol N 2007; 70/103\(1\): 72 77)] TJ ET BT 26.250 703.313 Td /F1 9.8 Tf [(76.)] TJ ET BT 45.502 703.313 Td /F1 9.8 Tf [(van Duijn E, Kingma EM, Timman R, et al. Cross-sectional study on prevalences of psychiatric disorders in )] TJ ET BT 26.250 687.869 Td /F1 9.8 Tf [(mutation carriers of Huntington s disease compared with mutation-negative first-degree relatives. J Clin )] TJ ET BT 26.250 672.425 Td /F1 9.8 Tf [(Psychiatry. 2008;69\(11\):1804-10.)] TJ ET BT 26.250 649.481 Td /F1 9.8 Tf [(77.)] TJ ET BT 45.502 649.481 Td /F1 9.8 Tf [(Alonso ME, Ochoa A, Boll M-C, et al. Clinical and genetic characteristics of Mexican Huntington s disease )] TJ ET BT 26.250 634.037 Td /F1 9.8 Tf [(patients. Movement. 2009;24\(13\):2012-5)] TJ ET BT 26.250 611.093 Td /F1 9.8 Tf [(78.)] TJ ET BT 45.502 611.093 Td /F1 9.8 Tf [(Torres G, Timana C, Cornejo M, et al. Molecular diagnosis of Huntington s disease in Peruvian population. )] TJ ET BT 26.250 595.649 Td /F1 9.8 Tf [(Mov Disord. 2010;25\(Suppl. 2\):S278)] TJ ET BT 26.250 572.705 Td /F1 9.8 Tf [(79.)] TJ ET BT 45.502 572.705 Td /F1 9.8 Tf [(Office for National Statistics. Annual Mid-year Population Estimates, 2010. Available at: )] TJ ET BT 26.250 557.261 Td /F1 9.8 Tf [(http://www.ons.gov.uk/ons/taxonomy/index.html?nscl=Population+Estimates. Accessed September 16, 2011.)] TJ ET BT 26.250 534.317 Td /F1 9.8 Tf [(80.)] TJ ET BT 45.502 534.317 Td /F1 9.8 Tf [(Gusella JF , Wexler NS, Conneally PM, Naylor SL, Anderson MA, Tanzi RE, Watkins PC, Ottina K, Wallace MR, )] TJ ET BT 26.250 518.873 Td /F1 9.8 Tf [(Sakaguchi AY \( 1983\) A polymorphic DNA marker genetically linked to Huntington s disease . Nature.1983 Nov )] TJ ET BT 26.250 503.429 Td /F1 9.8 Tf [(17-23; 306\(5940\):234-8.)] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 18.032 Td /F5 11.0 Tf [(20)] TJ ET BT 25.000 18.032 Td /F5 11.0 Tf [(PLOS Currents Huntington Disease)] TJ ET Q endstream endobj 881 0 obj <> endobj 882 0 obj <> stream /CIDInit /ProcSet findresource begin 12 dict begin begincmap /CIDSystemInfo <> def /CMapName /Adobe-Identity-UCS def /CMapType 2 def 1 begincodespacerange <0000> endcodespacerange 1 beginbfrange <0000> <0000> endbfrange endcmap CMapName currentdict /CMap defineresource pop end endendstream endobj 883 0 obj <> endobj 884 0 obj <> endobj 885 0 obj << /Filter /FlateDecode /Length 1484>> stream xcd˶m۶m۶msc۶۶m{nMGͽ'NLOڹW^k.R:WeT&eVeU6eWT.VU>WT!VU1W T)VU9WUT%UVUU5UW T-VU=W5T#5V5U35W T+VU;WuT'uVuU7uWT/VU?  0 (֘}kClձz[udϿEjҧL8m6Ot.\_ ]{u.X5A>=;%uzB>fMM MLYٚyZZEzWTKL+\tJu^?G}OOљO>ŧ43|7>g|/_|VOy*_k|sv9˹G5u>蛜7| R].;|Nu..{|~!?.G~OWt%Wv_3~yp{A O^ zY?XcO?"121;W?'Wſ.G)2F%F9"gܑ'FZQ F(EhQ"JƖ(]uF(BTJQ9!F5fԊQ'F (Gh͢y*ZGh}t):Gݢ{+zG 1(ǐbx1*Fǘb|L1)&ǔbz̈1+fǜb~,(XKcY,2VXkc]>61J{9_k~@V<=or]zZ+uLTv wĪ}Hͺ%oޘf죍;kMhƇvoؼxjU}W=aZNM|o*'& hm:;yv[[%'^:O_mvSkֶs} N򝒱s2vIƮ-S{L5﵇vu? 0(8O$OO4Og$dqzrC)R'ƒT)&yY2{{/]r*-^U^<_kbuۏc7&sy^YnmtSo0*O endstream endobj 886 0 obj << /Type /FontDescriptor /Flags 32 /FontName /LiberationSans /StemV 70 /Ascent 728 /Descent -210 /FontBBox [-203 -303 1050 910] /ItalicAngle 0 /FontFile2 887 0 R >> endobj 887 0 obj << /Length1 110660 /Length 110660 >> stream  LTSHh xOS/2w`VDMXPjcmapV_cvt :> ofpgms#f|gasp 4glyfj9wzhdmxn ?head,6hheaKd$hmtx)G pkern.5}|Zloca q:maxp  namehVhpost@prep\0m0:Z_<c^`gH >NC`gRT/Z33f Px1ASC@ Q3>`: 999Ws sIVHh !d9[99sPssgsNs/sRshsisYs`99edesTVVhV9g9 Vs9aV9aV].V  V.V-A999 sjsWsWsVsW9sVsssVssV99s1""\VVhV9asWsWsWsWsWsWWsWsWsWsW99 99ssVsVsVsVsVsssss3zss:ssQLPH-dA9GWdAd?dAs81%lB,dd3sd8sSsSVV9aaVsKKdAV-V`sXYs9K7VVVVV9999 9a9a9a933wPsV]9A1sVV-VseP)88Is9gsV9V]9hWhWsVkVsWVsWVVsWVsWs[sUsss9asV8V]9.9.ssA1A1h9abuVtVFV)0Ukedd"g{))+kUFQ@;@<fBUUEmmsVsWhWhWVsWVsWVsW9gsV9gsV9gsVss 999 9 999\ Vs~ss9asV9asVV]9.9ssss V-VsWB9G,9   V-~s:XP=]wWF2AVVX=VA9VX 3Z9aVl.V-V.W9V-VFsj`VsjsjVsVV`3?S`sV`?SW.UhV]99 u.7V@VUkVcC@9aVh.7vV.UUU.@i`sWx@sWZ1xx ksVUsW#V+zk-+7UsWs W99@ s kJOsq5+-|ZjZH-/ H% >u&5#'eS79]9q7$5S+7Ƥc  ) R M_c  S>+. . -%&%&.. 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