Author Profile

Fuat Balci

Affiliation: Department of Psychology, Koç University, Istanbul, Turkey

Koç University (BA) Rutgers University (MS) Rutgers University (Ph.D.) Rutgers University (Graduate Certificate in Cognitive Science) PsychoGenics Inc (Research Scientist) Princeton University (Post-doc) Koç University (Assistant Professor)

Recent Posts

Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington’s Disease

Huntington’s disease (HD) is a progressive neurodegenerative disease marked by psychiatric and motor problems. Recently, these findings have been extended to deficits in sleep and circadian function that can be observed in HD patients and in HD mouse models, with abnormal sleep patterns correlating with symptom severity in patients. Here, we studied the behavior of the BAC HD mouse model using an 24/7 automated system; the results indicate significant lengthening of the circadian period in the mutant mice. These results reinforce previous findings in HD models and symptomatic HD patients, indicating that circadian dysfunction is a core feature of HD.