http://currents.plos.org/influenza/article/fitness-of-pandemic-h1n1-and-seasonal-2e4ii3cnzi06d-2/ Wed, 16 Dec 2015 13:44:17 +0000 hourly 1 https://wordpress.org/?v=4.5.3 http://currents.plos.org/influenza/article/fitness-of-pandemic-h1n1-and-seasonal-2e4ii3cnzi06d-2/#comment-47 Sat, 05 Sep 2009 13:14:41 +0000 http://currents.plos.org/influenza/article/fitness-of-pandemic-h1n1-and-seasonal-2e4ii3cnzi06d-2/#comment-47 H5N1/H1N1 virus co-infection - Egypt (02): ex S.Arabia, NOT (Wednesday, September 2, 2009)"Jason L Garner, Senior Molecular Biologist, Global Influenza Surveillance: "A University of Maryland/NIH study, using ferret animal models, suggests that co-infections of A(H1N1) with seasonal flu viruses do not produce chimeric or reassortant viruses. Said another way, the A(H1N1) outcompetes seasonal viruses, possibly demonstrating the pandemic strain is not under biological pressure and is perhaps more efficiently communicable.However, with regard to the H5N1-A(H1N1) co-infections reported recently, there is no data to suggest these latest findings could apply to H5N1 co-infections. In light of the [lack of efficient transmission] characteristic that HPAI H5N1 has been shown to be a "dead-end" infection in humans, it could possibly be out-competed by a more robust strain such as A(H1N1) rather than being a player in a recombination event. [Or not!?!]."]]> Thanks guys for the “down to earth” approach, much appreciated. On the subject of viral evolution (or not) via co-infection, I agree with Jason Garner it would be very helpful to have controlled lab study data to gain insight into what’s probably happening in areas where naive politics creates obstacles for medicine and science. An example is Indonesia, where both H1N1/2009 and H5N1 are cross-species co-circulating…Cheers Then — Jonathon Singleton, Perth, Western Australia Excerpt from “PRO/AH/EDR> H5N1/H1N1 virus co-infection – Egypt (02): ex S.Arabia, NOT (Wednesday, September 2, 2009)”Jason L Garner, Senior Molecular Biologist, Global Influenza Surveillance: “A University of Maryland/NIH study, using ferret animal models, suggests that co-infections of A(H1N1) with seasonal flu viruses do not produce chimeric or reassortant viruses. Said another way, the A(H1N1) outcompetes seasonal viruses, possibly demonstrating the pandemic strain is not under biological pressure and is perhaps more efficiently communicable.However, with regard to the H5N1-A(H1N1) co-infections reported recently, there is no data to suggest these latest findings could apply to H5N1 co-infections. In light of the [lack of efficient transmission] characteristic that HPAI H5N1 has been shown to be a “dead-end” infection in humans, it could possibly be out-competed by a more robust strain such as A(H1N1) rather than being a player in a recombination event. [Or not!?!].”

]]> http://currents.plos.org/influenza/article/fitness-of-pandemic-h1n1-and-seasonal-2e4ii3cnzi06d-2/#comment-45 Sat, 05 Sep 2009 11:05:36 +0000 http://currents.plos.org/influenza/article/fitness-of-pandemic-h1n1-and-seasonal-2e4ii3cnzi06d-2/#comment-45 Please assist civilian comprehension — Doctors, professors and researchers –Could you kindly write a NY Times or CNN-style headline for your paper? What does your research mean to civilians or signify for influenza? 5 – 25 words, please, at high school level.I will include your headline in Swine Flu News & Influenza Times, http://knol.google.com/k/-/-/2srzofgvr8kjr/26#With gratitude,Murry

]]> http://currents.plos.org/influenza/article/fitness-of-pandemic-h1n1-and-seasonal-2e4ii3cnzi06d-2/#comment-49 Mon, 31 Aug 2009 08:30:54 +0000 http://currents.plos.org/influenza/article/fitness-of-pandemic-h1n1-and-seasonal-2e4ii3cnzi06d-2/#comment-49 Thanks, Daniel.Murry

]]> http://currents.plos.org/influenza/article/fitness-of-pandemic-h1n1-and-seasonal-2e4ii3cnzi06d-2/#comment-51 Mon, 31 Aug 2009 03:26:06 +0000 http://currents.plos.org/influenza/article/fitness-of-pandemic-h1n1-and-seasonal-2e4ii3cnzi06d-2/#comment-51 H1N1 Pandemic Virus Does Not Mutate Into ‘Superbug’ in UMd. Lab Study

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