%PDF-1.3 1 0 obj << /Type /Catalog /Outlines 2 0 R /Pages 3 0 R >> endobj 2 0 obj << /Type /Outlines /Count 0 >> endobj 3 0 obj << /Type /Pages /Kids [6 0 R 62 0 R 116 0 R 190 0 R 372 0 R 442 0 R 504 0 R 506 0 R ] /Count 8 /Resources << /ProcSet 4 0 R /Font << /F1 8 0 R /F2 9 0 R /F3 10 0 R /F4 11 0 R >> /XObject << /I1 12 0 R /I2 13 0 R /I3 68 0 R /I4 69 0 R /I5 70 0 R /I6 71 0 R /I7 72 0 R /I8 73 0 R /I9 74 0 R /I10 75 0 R /I11 78 0 R /I12 79 0 R /I13 84 0 R /I14 85 0 R /I15 86 0 R /I16 87 0 R /I17 88 0 R /I18 89 0 R /I19 90 0 R /I20 91 0 R /I21 94 0 R /I22 95 0 R /I23 100 0 R /I24 101 0 R /I25 102 0 R /I26 103 0 R /I27 104 0 R /I28 105 0 R /I29 106 0 R /I30 107 0 R /I31 110 0 R /I32 111 0 R /I33 112 0 R /I34 113 0 R /I35 114 0 R /I36 115 0 R /I37 118 0 R /I38 119 0 R /I39 138 0 R /I40 139 0 R /I41 142 0 R /I42 143 0 R /I43 162 0 R /I44 163 0 R /I45 166 0 R /I46 167 0 R /I47 186 0 R /I48 187 0 R /I49 208 0 R /I50 209 0 R /I51 210 0 R /I52 211 0 R /I53 214 0 R /I54 215 0 R /I55 216 0 R /I56 217 0 R /I57 218 0 R /I58 219 0 R /I59 230 0 R /I60 231 0 R /I61 232 0 R /I62 233 0 R /I63 234 0 R /I64 235 0 R /I65 236 0 R /I66 237 0 R /I67 240 0 R /I68 241 0 R /I69 242 0 R /I70 243 0 R /I71 244 0 R /I72 245 0 R /I73 248 0 R /I74 249 0 R /I75 266 0 R /I76 267 0 R /I77 268 0 R /I78 269 0 R /I79 272 0 R /I80 273 0 R /I81 274 0 R /I82 275 0 R /I83 276 0 R /I84 277 0 R /I85 288 0 R /I86 289 0 R /I87 290 0 R /I88 291 0 R /I89 292 0 R /I90 293 0 R /I91 294 0 R /I92 295 0 R /I93 298 0 R /I94 299 0 R /I95 300 0 R /I96 301 0 R /I97 302 0 R /I98 303 0 R /I99 306 0 R /I100 307 0 R /I101 324 0 R /I102 325 0 R /I103 326 0 R /I104 327 0 R /I105 330 0 R /I106 331 0 R /I107 332 0 R /I108 333 0 R /I109 334 0 R /I110 335 0 R /I111 346 0 R /I112 347 0 R /I113 348 0 R /I114 349 0 R /I115 350 0 R /I116 351 0 R /I117 352 0 R /I118 353 0 R /I119 356 0 R /I120 357 0 R /I121 358 0 R /I122 359 0 R /I123 360 0 R /I124 361 0 R /I125 364 0 R /I126 365 0 R /I127 366 0 R /I128 367 0 R /I129 368 0 R /I130 369 0 R /I131 370 0 R /I132 371 0 R /I133 374 0 R /I134 375 0 R /I135 378 0 R /I136 379 0 R /I137 382 0 R /I138 383 0 R /I139 384 0 R /I140 385 0 R /I141 388 0 R /I142 389 0 R /I143 392 0 R /I144 393 0 R /I145 394 0 R /I146 395 0 R /I147 398 0 R /I148 399 0 R /I149 402 0 R /I150 403 0 R /I151 404 0 R /I152 405 0 R /I153 408 0 R /I154 409 0 R /I155 412 0 R /I156 413 0 R /I157 414 0 R /I158 415 0 R /I159 418 0 R /I160 419 0 R /I161 422 0 R /I162 423 0 R /I163 424 0 R /I164 425 0 R /I165 428 0 R /I166 429 0 R /I167 432 0 R /I168 433 0 R /I169 434 0 R /I170 435 0 R /I171 436 0 R /I172 437 0 R /I173 438 0 R /I174 439 0 R /I175 440 0 R /I176 441 0 R /I177 444 0 R /I178 445 0 R /I179 448 0 R /I180 449 0 R /I181 450 0 R /I182 451 0 R /I183 454 0 R /I184 455 0 R /I185 456 0 R /I186 457 0 R /I187 460 0 R /I188 461 0 R /I189 462 0 R /I190 463 0 R /I191 466 0 R /I192 467 0 R /I193 468 0 R /I194 469 0 R /I195 472 0 R /I196 473 0 R /I197 474 0 R /I198 475 0 R /I199 478 0 R /I200 479 0 R /I201 480 0 R /I202 481 0 R /I203 484 0 R /I204 485 0 R /I205 486 0 R /I206 487 0 R /I207 490 0 R /I208 491 0 R /I209 492 0 R /I210 493 0 R /I211 496 0 R /I212 497 0 R /I213 498 0 R /I214 499 0 R /I215 500 0 R /I216 501 0 R /I217 502 0 R /I218 503 0 R >> >> /MediaBox [0.000 0.000 612.000 792.000] >> endobj 4 0 obj [/PDF /Text /ImageC ] endobj 5 0 obj << /Creator (DOMPDF) /CreationDate (D:20180721143423+00'00') /ModDate (D:20180721143423+00'00') /Title (Optimizing allocation for a delayed influenza vaccination campaign PLOS Currents Influenza) >> endobj 6 0 obj << /Type /Page /Parent 3 0 R /Annots [ 14 0 R 16 0 R 18 0 R 20 0 R 22 0 R 24 0 R 26 0 R 28 0 R 30 0 R 32 0 R 34 0 R 36 0 R 38 0 R 40 0 R 42 0 R 44 0 R 46 0 R 48 0 R 50 0 R 52 0 R 54 0 R 56 0 R 58 0 R 60 0 R ] /Contents 7 0 R >> endobj 7 0 obj << /Length 19841 >> stream q 375.000 0 0 39.000 222.000 738.000 cm /I2 Do Q q 15.000 684.354 577.500 53.646 re W n 0.267 0.267 0.267 rg BT 15.000 718.042 Td /F2 21.0 Tf [(Optimizing allocation for a delayed influenza vaccination )] TJ ET BT 15.000 693.094 Td /F2 21.0 Tf [(campaign)] TJ ET Q 0.271 0.267 0.267 rg BT 15.000 675.088 Td /F3 9.8 Tf [(December 13, 2009)] TJ ET BT 26.250 663.247 Td /F1 9.8 Tf [(, )] TJ ET BT 31.671 663.247 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 37.092 663.247 Td /F1 9.8 Tf [(Lauren Meyers)] TJ ET 0.271 0.267 0.267 rg BT 102.115 663.247 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 107.536 663.247 Td /F1 9.8 Tf [(Alison Galvani)] TJ ET 0.271 0.267 0.267 rg BT 169.848 663.247 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 175.269 663.247 Td /F1 9.8 Tf [(Jan Medlock)] TJ ET 0.271 0.267 0.267 rg BT 26.250 651.342 Td /F1 9.8 Tf [(Meyers L, Galvani A, Medlock J. Optimizing allocation for a delayed influenza vaccination campaign. PLOS Currents Influenza. )] TJ ET BT 26.250 639.438 Td /F1 9.8 Tf [(2009 Dec 13 . Edition 1. doi: 10.1371/currents.RRN1134.)] TJ ET q 15.000 35.720 577.500 601.336 re W n 0.271 0.267 0.267 rg BT 26.250 610.335 Td /F4 12.0 Tf [(Abstract)] TJ ET BT 26.250 590.381 Td /F1 9.8 Tf [(During unexpected infectious disease outbreaks, public health agencies must make effective use of limited resources. Vaccine )] TJ ET BT 26.250 578.476 Td /F1 9.8 Tf [(distribution may be delayed and staggered through time, as underscored by the 2009 H1N1 influenza pandemic. Using a )] TJ ET BT 26.250 566.571 Td /F1 9.8 Tf [(mathematical model parametrized with data from the 2009 H1N1 pandemic, we found that optimal allocations of vaccine among )] TJ ET BT 26.250 554.667 Td /F1 9.8 Tf [(people in different age groups and people with high-risk conditions depends on the schedule of vaccine availability relative to )] TJ ET BT 26.250 542.762 Td /F1 9.8 Tf [(the progress of the epidemic. For the projected schedule of H1N1 vaccine availability, the optimal strategy to reduce influenza-)] TJ ET BT 26.250 530.857 Td /F1 9.8 Tf [(related deaths is to initial target high-risk people, followed by school-aged children \(5-17\) and then young adults \(18-44\). The )] TJ ET BT 26.250 518.952 Td /F1 9.8 Tf [(optimal strategy to minimize hospitalizations, however, is to target ages 5-44 throughout the vaccination campaign, with only a )] TJ ET BT 26.250 507.048 Td /F1 9.8 Tf [(tiny amount of vaccine used on high-risk people. We find that optimizing at each vaccine release time independently does not )] TJ ET BT 26.250 495.143 Td /F1 9.8 Tf [(give the overall optimal strategy. In this manuscript, we derive policy recommendations for 2009 H1N1 vaccine allocation using )] TJ ET BT 26.250 483.238 Td /F1 9.8 Tf [(a mathematical model. In addition, our optimization procedures, which consider staggered releases over the entire epidemic )] TJ ET BT 26.250 471.333 Td /F1 9.8 Tf [(altogether, are applicable to other outbreaks where not all supplies are available initially.)] TJ ET BT 26.250 434.731 Td /F4 12.0 Tf [(Funding Statement)] TJ ET BT 26.250 414.777 Td /F1 9.8 Tf [(Funding was provided in part by NIH grant 1U01GM087719-01. JM was supported in part by start-up funding from the Clemson )] TJ ET BT 26.250 402.872 Td /F1 9.8 Tf [(University Department of Mathematical Sciences. The funders had no role in study design, data collection and analysis, )] TJ ET BT 26.250 390.967 Td /F1 9.8 Tf [(decision to publish, or preparation of the manuscript.)] TJ ET BT 26.250 361.865 Td /F4 12.0 Tf [(Introduction)] TJ ET BT 26.250 341.910 Td /F1 9.8 Tf [(Vaccines are critical to controlling the spread of influenza. The development and distribution of effective vaccines for new )] TJ ET BT 26.250 330.006 Td /F1 9.8 Tf [(pandemic strains may take several months, and not all the vaccine doses may be available at the same time. In addition, prior )] TJ ET BT 26.250 318.101 Td /F1 9.8 Tf [(to and throughout the vaccination period, a substantial fraction of the population may become infected and thereby naturally )] TJ ET BT 26.250 306.196 Td /F1 9.8 Tf [(immunized to re-infection. These dynamics change the transmission pattern and need to be considered in order to optimize )] TJ ET BT 26.250 294.291 Td /F1 9.8 Tf [(vaccine allocation.)] TJ ET BT 26.250 274.887 Td /F1 9.8 Tf [(Such changing dynamics are also the case for the 2009 H1N1 influenza pandemic. The first 2009 H1N1 vaccines were )] TJ ET BT 26.250 262.982 Td /F1 9.8 Tf [(distributed in the US in early October mainly to health care personnel and young children )] TJ ET 0.267 0.267 0.267 rg BT 411.550 262.982 Td /F1 9.8 Tf [([1])] TJ ET 0.271 0.267 0.267 rg BT 422.392 262.982 Td /F1 9.8 Tf [( . The Centers for Disease Control )] TJ ET BT 26.250 251.077 Td /F1 9.8 Tf [(and Prevention \(CDC\) projected that a total of 45 million doses would be available by mid-October, followed by 20 million doses )] TJ ET BT 26.250 239.172 Td /F1 9.8 Tf [(every week thereafter )] TJ ET 0.267 0.267 0.267 rg BT 122.707 239.172 Td /F1 9.8 Tf [([2])] TJ ET 0.271 0.267 0.267 rg BT 133.549 239.172 Td /F1 9.8 Tf [( . The optimal allocation of influenza vaccines when vaccination is delayed and staggered throughout )] TJ ET BT 26.250 227.268 Td /F1 9.8 Tf [(the epidemic period is critical to public health, yet may differ substantially from the optimal allocation of vaccines prior to an )] TJ ET BT 26.250 215.363 Td /F1 9.8 Tf [(epidemic. Here we evaluate age-specific and risk-specific vaccine allocation strategies according to the CDCs projected 2009-)] TJ ET BT 26.250 203.458 Td /F1 9.8 Tf [(2010 schedule of vaccine availability for 2009 H1N1.)] TJ ET BT 26.250 184.053 Td /F1 9.8 Tf [(Public health agencies often consider projected impacts on deaths and hospitalizations when determining intervention policy )] TJ ET 0.267 0.267 0.267 rg BT 563.836 184.053 Td /F1 9.8 Tf [([3])] TJ ET 0.271 0.267 0.267 rg BT 26.250 172.149 Td /F1 9.8 Tf [(. Severe infections that require hospitalization have the potential to exceed the capacity of health services, particularly at the )] TJ ET BT 26.250 160.244 Td /F1 9.8 Tf [(peak of an outbreak. Averting deaths is also clearly a prime humanitarian goal. We determine the optimal allocation of vaccines )] TJ ET BT 26.250 148.339 Td /F1 9.8 Tf [(according to both of these measures by employing an optimization procedure that explicitly incorporates the transmission )] TJ ET BT 26.250 136.434 Td /F1 9.8 Tf [(dynamics of 2009 H1N1 influenza prior to and throughout the vaccination period.)] TJ ET Q q 15.000 684.354 577.500 53.646 re W n 0.267 0.267 0.267 rg BT 15.000 718.042 Td /F2 21.0 Tf [(Optimizing allocation for a delayed influenza vaccination )] TJ ET BT 15.000 693.094 Td /F2 21.0 Tf [(campaign)] TJ ET Q 0.271 0.267 0.267 rg BT 15.000 675.088 Td /F3 9.8 Tf [(December 13, 2009)] TJ ET BT 26.250 663.247 Td /F1 9.8 Tf [(, )] TJ ET BT 31.671 663.247 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 37.092 663.247 Td /F1 9.8 Tf [(Lauren Meyers)] TJ ET 0.271 0.267 0.267 rg BT 102.115 663.247 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 107.536 663.247 Td /F1 9.8 Tf [(Alison Galvani)] TJ ET 0.271 0.267 0.267 rg BT 169.848 663.247 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 175.269 663.247 Td /F1 9.8 Tf [(Jan Medlock)] TJ ET 0.271 0.267 0.267 rg BT 26.250 651.342 Td /F1 9.8 Tf [(Meyers L, Galvani A, Medlock J. Optimizing allocation for a delayed influenza vaccination campaign. PLOS Currents Influenza. )] TJ ET BT 26.250 639.438 Td /F1 9.8 Tf [(2009 Dec 13 . Edition 1. doi: 10.1371/currents.RRN1134.)] TJ ET q 15.000 35.720 577.500 601.336 re W n 0.271 0.267 0.267 rg BT 26.250 610.335 Td /F4 12.0 Tf [(Abstract)] TJ ET BT 26.250 590.381 Td /F1 9.8 Tf [(During unexpected infectious disease outbreaks, public health agencies must make effective use of limited resources. Vaccine )] TJ ET BT 26.250 578.476 Td /F1 9.8 Tf [(distribution may be delayed and staggered through time, as underscored by the 2009 H1N1 influenza pandemic. Using a )] TJ ET BT 26.250 566.571 Td /F1 9.8 Tf [(mathematical model parametrized with data from the 2009 H1N1 pandemic, we found that optimal allocations of vaccine among )] TJ ET BT 26.250 554.667 Td /F1 9.8 Tf [(people in different age groups and people with high-risk conditions depends on the schedule of vaccine availability relative to )] TJ ET BT 26.250 542.762 Td /F1 9.8 Tf [(the progress of the epidemic. For the projected schedule of H1N1 vaccine availability, the optimal strategy to reduce influenza-)] TJ ET BT 26.250 530.857 Td /F1 9.8 Tf [(related deaths is to initial target high-risk people, followed by school-aged children \(5-17\) and then young adults \(18-44\). The )] TJ ET BT 26.250 518.952 Td /F1 9.8 Tf [(optimal strategy to minimize hospitalizations, however, is to target ages 5-44 throughout the vaccination campaign, with only a )] TJ ET BT 26.250 507.048 Td /F1 9.8 Tf [(tiny amount of vaccine used on high-risk people. We find that optimizing at each vaccine release time independently does not )] TJ ET BT 26.250 495.143 Td /F1 9.8 Tf [(give the overall optimal strategy. In this manuscript, we derive policy recommendations for 2009 H1N1 vaccine allocation using )] TJ ET BT 26.250 483.238 Td /F1 9.8 Tf [(a mathematical model. In addition, our optimization procedures, which consider staggered releases over the entire epidemic )] TJ ET BT 26.250 471.333 Td /F1 9.8 Tf [(altogether, are applicable to other outbreaks where not all supplies are available initially.)] TJ ET BT 26.250 434.731 Td /F4 12.0 Tf [(Funding Statement)] TJ ET BT 26.250 414.777 Td /F1 9.8 Tf [(Funding was provided in part by NIH grant 1U01GM087719-01. JM was supported in part by start-up funding from the Clemson )] TJ ET BT 26.250 402.872 Td /F1 9.8 Tf [(University Department of Mathematical Sciences. The funders had no role in study design, data collection and analysis, )] TJ ET BT 26.250 390.967 Td /F1 9.8 Tf [(decision to publish, or preparation of the manuscript.)] TJ ET BT 26.250 361.865 Td /F4 12.0 Tf [(Introduction)] TJ ET BT 26.250 341.910 Td /F1 9.8 Tf [(Vaccines are critical to controlling the spread of influenza. The development and distribution of effective vaccines for new )] TJ ET BT 26.250 330.006 Td /F1 9.8 Tf [(pandemic strains may take several months, and not all the vaccine doses may be available at the same time. In addition, prior )] TJ ET BT 26.250 318.101 Td /F1 9.8 Tf [(to and throughout the vaccination period, a substantial fraction of the population may become infected and thereby naturally )] TJ ET BT 26.250 306.196 Td /F1 9.8 Tf [(immunized to re-infection. These dynamics change the transmission pattern and need to be considered in order to optimize )] TJ ET BT 26.250 294.291 Td /F1 9.8 Tf [(vaccine allocation.)] TJ ET BT 26.250 274.887 Td /F1 9.8 Tf [(Such changing dynamics are also the case for the 2009 H1N1 influenza pandemic. The first 2009 H1N1 vaccines were )] TJ ET BT 26.250 262.982 Td /F1 9.8 Tf [(distributed in the US in early October mainly to health care personnel and young children )] TJ ET 0.267 0.267 0.267 rg BT 411.550 262.982 Td /F1 9.8 Tf [([1])] TJ ET 0.271 0.267 0.267 rg BT 422.392 262.982 Td /F1 9.8 Tf [( . The Centers for Disease Control )] TJ ET BT 26.250 251.077 Td /F1 9.8 Tf [(and Prevention \(CDC\) projected that a total of 45 million doses would be available by mid-October, followed by 20 million doses )] TJ ET BT 26.250 239.172 Td /F1 9.8 Tf [(every week thereafter )] TJ ET 0.267 0.267 0.267 rg BT 122.707 239.172 Td /F1 9.8 Tf [([2])] TJ ET 0.271 0.267 0.267 rg BT 133.549 239.172 Td /F1 9.8 Tf [( . The optimal allocation of influenza vaccines when vaccination is delayed and staggered throughout )] TJ ET BT 26.250 227.268 Td /F1 9.8 Tf [(the epidemic period is critical to public health, yet may differ substantially from the optimal allocation of vaccines prior to an )] TJ ET BT 26.250 215.363 Td /F1 9.8 Tf [(epidemic. Here we evaluate age-specific and risk-specific vaccine allocation strategies according to the CDCs projected 2009-)] TJ ET BT 26.250 203.458 Td /F1 9.8 Tf [(2010 schedule of vaccine availability for 2009 H1N1.)] TJ ET BT 26.250 184.053 Td /F1 9.8 Tf [(Public health agencies often consider projected impacts on deaths and hospitalizations when determining intervention policy )] TJ ET 0.267 0.267 0.267 rg BT 563.836 184.053 Td /F1 9.8 Tf [([3])] TJ ET 0.271 0.267 0.267 rg BT 26.250 172.149 Td /F1 9.8 Tf [(. Severe infections that require hospitalization have the potential to exceed the capacity of health services, particularly at the )] TJ ET BT 26.250 160.244 Td /F1 9.8 Tf [(peak of an outbreak. Averting deaths is also clearly a prime humanitarian goal. We determine the optimal allocation of vaccines )] TJ ET BT 26.250 148.339 Td /F1 9.8 Tf [(according to both of these measures by employing an optimization procedure that explicitly incorporates the transmission )] TJ ET BT 26.250 136.434 Td /F1 9.8 Tf [(dynamics of 2009 H1N1 influenza prior to and throughout the vaccination period.)] TJ ET Q q 15.000 684.354 577.500 53.646 re W n 0.267 0.267 0.267 rg BT 15.000 718.042 Td /F2 21.0 Tf [(Optimizing allocation for a delayed influenza vaccination )] TJ ET BT 15.000 693.094 Td /F2 21.0 Tf [(campaign)] TJ ET Q 0.271 0.267 0.267 rg BT 15.000 675.088 Td /F3 9.8 Tf [(December 13, 2009)] TJ ET BT 26.250 663.247 Td /F1 9.8 Tf [(, )] TJ ET BT 31.671 663.247 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 37.092 663.247 Td /F1 9.8 Tf [(Lauren Meyers)] TJ ET 0.271 0.267 0.267 rg BT 102.115 663.247 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 107.536 663.247 Td /F1 9.8 Tf [(Alison Galvani)] TJ ET 0.271 0.267 0.267 rg BT 169.848 663.247 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 175.269 663.247 Td /F1 9.8 Tf [(Jan Medlock)] TJ ET 0.271 0.267 0.267 rg BT 26.250 651.342 Td /F1 9.8 Tf [(Meyers L, Galvani A, Medlock J. Optimizing allocation for a delayed influenza vaccination campaign. PLOS Currents Influenza. )] TJ ET BT 26.250 639.438 Td /F1 9.8 Tf [(2009 Dec 13 . Edition 1. doi: 10.1371/currents.RRN1134.)] TJ ET q 15.000 35.720 577.500 601.336 re W n 0.271 0.267 0.267 rg BT 26.250 610.335 Td /F4 12.0 Tf [(Abstract)] TJ ET BT 26.250 590.381 Td /F1 9.8 Tf [(During unexpected infectious disease outbreaks, public health agencies must make effective use of limited resources. Vaccine )] TJ ET BT 26.250 578.476 Td /F1 9.8 Tf [(distribution may be delayed and staggered through time, as underscored by the 2009 H1N1 influenza pandemic. Using a )] TJ ET BT 26.250 566.571 Td /F1 9.8 Tf [(mathematical model parametrized with data from the 2009 H1N1 pandemic, we found that optimal allocations of vaccine among )] TJ ET BT 26.250 554.667 Td /F1 9.8 Tf [(people in different age groups and people with high-risk conditions depends on the schedule of vaccine availability relative to )] TJ ET BT 26.250 542.762 Td /F1 9.8 Tf [(the progress of the epidemic. For the projected schedule of H1N1 vaccine availability, the optimal strategy to reduce influenza-)] TJ ET BT 26.250 530.857 Td /F1 9.8 Tf [(related deaths is to initial target high-risk people, followed by school-aged children \(5-17\) and then young adults \(18-44\). The )] TJ ET BT 26.250 518.952 Td /F1 9.8 Tf [(optimal strategy to minimize hospitalizations, however, is to target ages 5-44 throughout the vaccination campaign, with only a )] TJ ET BT 26.250 507.048 Td /F1 9.8 Tf [(tiny amount of vaccine used on high-risk people. We find that optimizing at each vaccine release time independently does not )] TJ ET BT 26.250 495.143 Td /F1 9.8 Tf [(give the overall optimal strategy. In this manuscript, we derive policy recommendations for 2009 H1N1 vaccine allocation using )] TJ ET BT 26.250 483.238 Td /F1 9.8 Tf [(a mathematical model. In addition, our optimization procedures, which consider staggered releases over the entire epidemic )] TJ ET BT 26.250 471.333 Td /F1 9.8 Tf [(altogether, are applicable to other outbreaks where not all supplies are available initially.)] TJ ET BT 26.250 434.731 Td /F4 12.0 Tf [(Funding Statement)] TJ ET BT 26.250 414.777 Td /F1 9.8 Tf [(Funding was provided in part by NIH grant 1U01GM087719-01. JM was supported in part by start-up funding from the Clemson )] TJ ET BT 26.250 402.872 Td /F1 9.8 Tf [(University Department of Mathematical Sciences. The funders had no role in study design, data collection and analysis, )] TJ ET BT 26.250 390.967 Td /F1 9.8 Tf [(decision to publish, or preparation of the manuscript.)] TJ ET BT 26.250 361.865 Td /F4 12.0 Tf [(Introduction)] TJ ET BT 26.250 341.910 Td /F1 9.8 Tf [(Vaccines are critical to controlling the spread of influenza. The development and distribution of effective vaccines for new )] TJ ET BT 26.250 330.006 Td /F1 9.8 Tf [(pandemic strains may take several months, and not all the vaccine doses may be available at the same time. In addition, prior )] TJ ET BT 26.250 318.101 Td /F1 9.8 Tf [(to and throughout the vaccination period, a substantial fraction of the population may become infected and thereby naturally )] TJ ET BT 26.250 306.196 Td /F1 9.8 Tf [(immunized to re-infection. These dynamics change the transmission pattern and need to be considered in order to optimize )] TJ ET BT 26.250 294.291 Td /F1 9.8 Tf [(vaccine allocation.)] TJ ET BT 26.250 274.887 Td /F1 9.8 Tf [(Such changing dynamics are also the case for the 2009 H1N1 influenza pandemic. The first 2009 H1N1 vaccines were )] TJ ET BT 26.250 262.982 Td /F1 9.8 Tf [(distributed in the US in early October mainly to health care personnel and young children )] TJ ET 0.267 0.267 0.267 rg BT 411.550 262.982 Td /F1 9.8 Tf [([1])] TJ ET 0.271 0.267 0.267 rg BT 422.392 262.982 Td /F1 9.8 Tf [( . The Centers for Disease Control )] TJ ET BT 26.250 251.077 Td /F1 9.8 Tf [(and Prevention \(CDC\) projected that a total of 45 million doses would be available by mid-October, followed by 20 million doses )] TJ ET BT 26.250 239.172 Td /F1 9.8 Tf [(every week thereafter )] TJ ET 0.267 0.267 0.267 rg BT 122.707 239.172 Td /F1 9.8 Tf [([2])] TJ ET 0.271 0.267 0.267 rg BT 133.549 239.172 Td /F1 9.8 Tf [( . The optimal allocation of influenza vaccines when vaccination is delayed and staggered throughout )] TJ ET BT 26.250 227.268 Td /F1 9.8 Tf [(the epidemic period is critical to public health, yet may differ substantially from the optimal allocation of vaccines prior to an )] TJ ET BT 26.250 215.363 Td /F1 9.8 Tf [(epidemic. Here we evaluate age-specific and risk-specific vaccine allocation strategies according to the CDCs projected 2009-)] TJ ET BT 26.250 203.458 Td /F1 9.8 Tf [(2010 schedule of vaccine availability for 2009 H1N1.)] TJ ET BT 26.250 184.053 Td /F1 9.8 Tf [(Public health agencies often consider projected impacts on deaths and hospitalizations when determining intervention policy )] TJ ET 0.267 0.267 0.267 rg BT 563.836 184.053 Td /F1 9.8 Tf [([3])] TJ ET 0.271 0.267 0.267 rg BT 26.250 172.149 Td /F1 9.8 Tf [(. Severe infections that require hospitalization have the potential to exceed the capacity of health services, particularly at the )] TJ ET BT 26.250 160.244 Td /F1 9.8 Tf [(peak of an outbreak. Averting deaths is also clearly a prime humanitarian goal. We determine the optimal allocation of vaccines )] TJ ET BT 26.250 148.339 Td /F1 9.8 Tf [(according to both of these measures by employing an optimization procedure that explicitly incorporates the transmission )] TJ ET BT 26.250 136.434 Td /F1 9.8 Tf [(dynamics of 2009 H1N1 influenza prior to and throughout the vaccination period.)] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(1)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Influenza)] TJ ET Q endstream endobj 8 0 obj << /Type /Font /Subtype /Type1 /Name /F1 /BaseFont /Helvetica /Encoding /WinAnsiEncoding >> endobj 9 0 obj << /Type /Font /Subtype /Type1 /Name /F2 /BaseFont /Times-Bold /Encoding /WinAnsiEncoding >> endobj 10 0 obj << /Type /Font /Subtype /Type1 /Name /F3 /BaseFont /Times-Italic /Encoding /WinAnsiEncoding >> endobj 11 0 obj << /Type /Font /Subtype /Type1 /Name /F4 /BaseFont /Helvetica-Bold /Encoding /WinAnsiEncoding >> endobj 12 0 obj << /Type /XObject /Subtype /Image /Width 500 /Height 52 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 500 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 144>> stream x1 0 'ݲ؎"e{dzAdzAdzAdzAdzAdzAdzAdzAdzAdzAdzAdzAtlM0\ endstream endobj 13 0 obj << /Type /XObject /Subtype /Image /Width 500 /Height 52 /SMask 12 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 500 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 3574>> stream x}ƕK*8+0T ֮ S L*0߇d" sl2FBiFwY0 00 0ŝa0 aqgR܋x||lu2 03UL۶BxI 0:UU0x;֝($z%șHڶ ÐVz ]IS> â(.* TQUuL5 $>BvpH0U:xkkGJT{OɗRNyGOΙyn)q7`(~_Ji2vgk]qVꔷ3N'ȴy4Ikm6!q:FJ)-0n܋v!^}_Z l61va_~Bxw8mv;EJY8}zzQ3]Pȹ,2_jfY4MQ[ '.uO O͋kշ9b6.#ߦUUzhf09+nKɿ4 f7Bu7ĨMfrF0`s8429j1}ZWDW;A4ҫ'TQ{7Cb[$ -"ΨMQgzN/2R7Tco*W:N݋6TUu8`RSi O>r;z^m(0w`:m=]գCE&t |ZYQ%{X[nR+zbEFΧ5pzq`ުం Ih{9G 4wMx' nmvEZ sg7?ZQ}&ҎKGuPu.j8UgNKꓙQC)s#$1䧈x[Z(|Xzc;t<~50Hh_T3Ur>a$]B8Fz[?K>Y/rQ=E4?EaLqzpX!(nNut]}e(/S\fz,<ZOEa]0 sCS_}I Y}n۶r(fg7#)h6ա}$ üvq]Aא$c0ddBDQ)ueypU-z~9Hk<$I©y'Tk`yY d}e{䨙ǐu>&w񚓶('GI\rm[G4 Sk7$B pEkYYC/ 9&Ʋ[V9MQ':X|C֨ʉ jt"ޡ+rttBռGdiM FuTEi(łv]fk"8Ldp' ^הMup2`M?dE!|KJ-\.MzکC=&¾HfR7$ev,La0+$OFuEQ"i,ːN?~E*t4qΚF:t`,{RkR]ޜ(Ԕѣ$IbN}5لS1(Ȱ$I$(eWp8Lٱ3߯ky۶&. Ck+'kL'`YG<=jͦ:l/@ߧ x$'UewYV_|H獃ׯ_ϲ,j##k4=n̲,KSq^m[P'̚ݮ(8.ﱟ5f3Mh'Ͳ I.u7~~Ӫ 3'i91ӜP j0kY4jBv04Y-CV'9H藗̑ʬEFXR8~CBBg,J}<?#&(X} vm-- 1F<6 d 䣨*mރ,;]u X.a_sOH5auUyӪ 3qwIX"@ צYZ iLA+-^!;5 ނ_gB<t 0|wX~2bўk۶{0W\.g{,O3 ֊Ѣz4pumqu&38E=X}R~mrt,۩Z]B}TSY i zʲDs# w]m+­{bqFQdu2wa+ ѣ=t,70 3[d` D"-eLwQG[0 ]h9I 0/{tFwca~!-0 B.aa~ Xa> , 0wa;0ŝa?9 endstream endobj 14 0 obj << /Type /Annot /Subtype /Link /A 15 0 R /Border [0 0 0] /H /I /Rect [ 15.0000 716.1516 532.4400 736.9416 ] >> endobj 15 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/article/optimizing-allocation-for-a-delayed-3hdphgna5k6zf-1/) >> endobj 16 0 obj << /Type /Annot /Subtype /Link /A 17 0 R /Border [0 0 0] /H /I /Rect [ 15.0000 691.2036 102.5070 711.9936 ] >> endobj 17 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/article/optimizing-allocation-for-a-delayed-3hdphgna5k6zf-1/) >> endobj 18 0 obj << /Type /Annot /Subtype /Link /A 19 0 R /Border [0 0 0] /H /I /Rect [ 37.0920 662.3453 102.1148 672.2659 ] >> endobj 19 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/author/laurenmeyers/) >> endobj 20 0 obj << /Type /Annot /Subtype /Link /A 21 0 R /Border [0 0 0] /H /I /Rect [ 107.5358 662.3453 169.8480 672.2659 ] >> endobj 21 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/author/alisongalvani/) >> endobj 22 0 obj << /Type /Annot /Subtype /Link /A 23 0 R /Border [0 0 0] /H /I /Rect [ 175.2690 662.3453 229.9958 672.2659 ] >> endobj 23 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/author/janmedlock/) >> endobj 24 0 obj << /Type /Annot /Subtype /Link /A 25 0 R /Border [0 0 0] /H /I /Rect [ 411.5505 262.0801 422.3925 272.0007 ] >> endobj 25 0 obj << /Type /Action >> endobj 26 0 obj << /Type /Annot /Subtype /Link /A 27 0 R /Border [0 0 0] /H /I /Rect [ 122.7067 238.2706 133.5488 248.1912 ] >> endobj 27 0 obj << /Type /Action >> endobj 28 0 obj << /Type /Annot /Subtype /Link /A 29 0 R /Border [0 0 0] /H /I /Rect [ 563.8357 183.1516 574.6777 193.0722 ] >> endobj 29 0 obj << /Type /Action >> endobj 30 0 obj << /Type /Annot /Subtype /Link /A 31 0 R /Border [0 0 0] /H /I /Rect [ 15.0000 716.1516 532.4400 736.9416 ] >> endobj 31 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/article/optimizing-allocation-for-a-delayed-3hdphgna5k6zf-1/) >> endobj 32 0 obj << /Type /Annot /Subtype /Link /A 33 0 R /Border [0 0 0] /H /I /Rect [ 15.0000 691.2036 102.5070 711.9936 ] >> endobj 33 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/article/optimizing-allocation-for-a-delayed-3hdphgna5k6zf-1/) >> endobj 34 0 obj << /Type /Annot /Subtype /Link /A 35 0 R /Border [0 0 0] /H /I /Rect [ 37.0920 662.3453 102.1148 672.2659 ] >> endobj 35 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/author/laurenmeyers/) >> endobj 36 0 obj << /Type /Annot /Subtype /Link /A 37 0 R /Border [0 0 0] /H /I /Rect [ 107.5358 662.3453 169.8480 672.2659 ] >> endobj 37 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/author/alisongalvani/) >> endobj 38 0 obj << /Type /Annot /Subtype /Link /A 39 0 R /Border [0 0 0] /H /I /Rect [ 175.2690 662.3453 229.9958 672.2659 ] >> endobj 39 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/author/janmedlock/) >> endobj 40 0 obj << /Type /Annot /Subtype /Link /A 41 0 R /Border [0 0 0] /H /I /Rect [ 411.5505 262.0801 422.3925 272.0007 ] >> endobj 41 0 obj << /Type /Action >> endobj 42 0 obj << /Type /Annot /Subtype /Link /A 43 0 R /Border [0 0 0] /H /I /Rect [ 122.7067 238.2706 133.5488 248.1912 ] >> endobj 43 0 obj << /Type /Action >> endobj 44 0 obj << /Type /Annot /Subtype /Link /A 45 0 R /Border [0 0 0] /H /I /Rect [ 563.8357 183.1516 574.6777 193.0722 ] >> endobj 45 0 obj << /Type /Action >> endobj 46 0 obj << /Type /Annot /Subtype /Link /A 47 0 R /Border [0 0 0] /H /I /Rect [ 15.0000 716.1516 532.4400 736.9416 ] >> endobj 47 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/article/optimizing-allocation-for-a-delayed-3hdphgna5k6zf-1/) >> endobj 48 0 obj << /Type /Annot /Subtype /Link /A 49 0 R /Border [0 0 0] /H /I /Rect [ 15.0000 691.2036 102.5070 711.9936 ] >> endobj 49 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/article/optimizing-allocation-for-a-delayed-3hdphgna5k6zf-1/) >> endobj 50 0 obj << /Type /Annot /Subtype /Link /A 51 0 R /Border [0 0 0] /H /I /Rect [ 37.0920 662.3453 102.1148 672.2659 ] >> endobj 51 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/author/laurenmeyers/) >> endobj 52 0 obj << /Type /Annot /Subtype /Link /A 53 0 R /Border [0 0 0] /H /I /Rect [ 107.5358 662.3453 169.8480 672.2659 ] >> endobj 53 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/author/alisongalvani/) >> endobj 54 0 obj << /Type /Annot /Subtype /Link /A 55 0 R /Border [0 0 0] /H /I /Rect [ 175.2690 662.3453 229.9958 672.2659 ] >> endobj 55 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/author/janmedlock/) >> endobj 56 0 obj << /Type /Annot /Subtype /Link /A 57 0 R /Border [0 0 0] /H /I /Rect [ 411.5505 262.0801 422.3925 272.0007 ] >> endobj 57 0 obj << /Type /Action >> endobj 58 0 obj << /Type /Annot /Subtype /Link /A 59 0 R /Border [0 0 0] /H /I /Rect [ 122.7067 238.2706 133.5488 248.1912 ] >> endobj 59 0 obj << /Type /Action >> endobj 60 0 obj << /Type /Annot /Subtype /Link /A 61 0 R /Border [0 0 0] /H /I /Rect [ 563.8357 183.1516 574.6777 193.0722 ] >> endobj 61 0 obj << /Type /Action >> endobj 62 0 obj << /Type /Page /Parent 3 0 R /Annots [ 64 0 R 66 0 R 76 0 R 80 0 R 82 0 R 92 0 R 96 0 R 98 0 R 108 0 R ] /Contents 63 0 R >> endobj 63 0 obj << /Length 19354 >> stream 0.271 0.267 0.267 rg q 15.000 -13.871 577.500 790.871 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(Our analysis indicates that both deaths and hospitalizations can be minimized by prioritizing the vaccination of school-aged )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(children \(5-17\), young adults \(18-44\), and people at high-risk of severe infections. However, the temporal order of prioritization )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(differs between these two outcome measures when staggered vaccination schedules are considered. Deaths can be minimized )] TJ ET BT 26.250 731.762 Td /F1 9.8 Tf [(by prioritizing high-risk people first, followed by schoolchildren and young adults. In contrast, hospitalizations are optimally )] TJ ET BT 26.250 719.857 Td /F1 9.8 Tf [(averted by first prioritizing schoolchildren and young adults, followed by high-risk people. In contrast to both optimal strategies, )] TJ ET BT 26.250 707.952 Td /F1 9.8 Tf [(the CDC recommends prioritizing high-risk people and people aged 6 months through 24 years )] TJ ET 0.267 0.267 0.267 rg BT 438.090 707.952 Td /F1 9.8 Tf [([4])] TJ ET 0.271 0.267 0.267 rg BT 448.932 707.952 Td /F1 9.8 Tf [( . Both deaths and )] TJ ET BT 26.250 696.048 Td /F1 9.8 Tf [(hospitalizations for the 2009 H1N1 pandemic could be reduced by shifting focus to schoolchildren and young adults.)] TJ ET BT 26.250 659.445 Td /F4 12.0 Tf [(Results)] TJ ET BT 26.250 639.491 Td /F1 9.8 Tf [(To minimize deaths, the optimal policy is for the first two batches of vaccine to be allocated to high-risk people, followed by )] TJ ET BT 26.250 627.586 Td /F1 9.8 Tf [(schoolchildren \(ages 5-17\) and then young adults \(ages 18-44\) \(Figure 1A\). To minimize hospitalizations, the first five batches )] TJ ET BT 26.250 615.681 Td /F1 9.8 Tf [(should be allocated to schoolchildren and young adults, with a small amount of vaccine also allocated to high-risk people in the )] TJ ET BT 26.250 603.777 Td /F1 9.8 Tf [(fifth batch \(Figure 1B\).)] TJ ET 0.965 0.965 0.965 rg 26.250 362.141 555.000 231.755 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 593.896 m 581.250 593.896 l 581.250 593.146 l 26.250 593.146 l f 26.250 362.141 m 581.250 362.141 l 581.250 362.891 l 26.250 362.891 l f q 112.500 0 0 112.500 35.250 471.646 cm /I4 Do Q q 35.250 373.391 537.000 92.255 re W n 0.271 0.267 0.267 rg BT 35.250 456.122 Td /F4 9.8 Tf [(Fig. 1: Optimal vaccine allocation for different vaccine delivery schedules, different values of , and different )] TJ ET BT 35.250 444.217 Td /F4 9.8 Tf [(objectives.)] TJ ET BT 35.250 424.847 Td /F1 9.8 Tf [(The delivery schedule 45M + 4 20M doses corresponds to five batches of vaccine delivery: 45M doses on 15 October )] TJ ET BT 35.250 411.111 Td /F1 9.8 Tf [(and 20M doses each of the following four weeks. The different shades of blue correspond to the optimal allocation of the )] TJ ET BT 35.250 397.375 Td /F1 9.8 Tf [(different delivery batches. The green and red bars indicate the optimal allocations under hypothetical early delivery )] TJ ET BT 35.250 383.638 Td /F1 9.8 Tf [(scenarios of 125M doses on 15 October and prior to the outbreak, respectively.)] TJ ET Q BT 26.250 343.841 Td /F1 9.8 Tf [(As the basic reproductive number \()] TJ ET q 16.500 0 0 13.500 177.434 341.141 cm /I6 Do Q BT 193.934 343.841 Td /F1 9.8 Tf [(\) increases, optimal allocation to minimize deaths no longer includes schoolchildren )] TJ ET BT 26.250 331.617 Td /F1 9.8 Tf [(\(Figure 1C\), while optimal allocation for hospitalizations shifts to include high-risk people \(Figure 1D\). This is due in part to )] TJ ET BT 26.250 318.436 Td /F1 9.8 Tf [(acquired immunity: for )] TJ ET q 47.250 0 0 13.500 124.862 315.736 cm /I8 Do Q BT 172.112 318.436 Td /F1 9.8 Tf [(, only 11% of schoolchildren have been infected before the first vaccine is available on 15 )] TJ ET BT 26.250 304.936 Td /F1 9.8 Tf [(October, whereas, for )] TJ ET q 47.250 0 0 13.500 122.707 302.236 cm /I10 Do Q BT 169.957 304.936 Td /F1 9.8 Tf [(, 45% of schoolchildren have been infected by 15 October.)] TJ ET BT 26.250 292.713 Td /F1 9.8 Tf [(The optimal allocation is sensitive to the scheduling of release times. Consequently, evaluation of each batch separately does )] TJ ET BT 26.250 280.808 Td /F1 9.8 Tf [(not generate the allocation strategy that is optimal overall \(see Text S1 and Figures S3-S10\). For example, when only two total )] TJ ET BT 26.250 268.903 Td /F1 9.8 Tf [(batches are available \(45 million doses on 15 October and 20 million on 22 October\), deaths can be minimized by allocating the )] TJ ET BT 26.250 256.998 Td /F1 9.8 Tf [(first batch to schoolchildren and the second batch to adults aged 18-44 \(Figure S3\). In contrast, when 3 total batches are )] TJ ET BT 26.250 245.094 Td /F1 9.8 Tf [(available \(45 million doses on 15 October and 20 million on each of 22 October and 29 October\), the first two batches are )] TJ ET BT 26.250 233.189 Td /F1 9.8 Tf [(optimally split between schoolchildren and high-risk people and the third batch is used exclusively on high-risk people.)] TJ ET BT 26.250 213.784 Td /F1 9.8 Tf [(The projected reductions in infections, deaths, and hospitalizations are substantial for both sets of optimized vaccination )] TJ ET BT 26.250 201.879 Td /F1 9.8 Tf [(strategies \(Figure 2\). The strategy that minimizes hospitalizations is predicted to reduce the total attack rate more effectively )] TJ ET BT 26.250 189.975 Td /F1 9.8 Tf [(than the strategy that minimizes deaths \(11.4% versus 15.2% of the population infected, respectively\). Comparing the number )] TJ ET BT 26.250 178.070 Td /F1 9.8 Tf [(of deaths and hospitalizations, the strategy that minimizes deaths results in 8000 fewer deaths \(a 23% reduction\) and 44,000 )] TJ ET BT 26.250 166.165 Td /F1 9.8 Tf [(more hospitalizations \(a 9% increase\) than the strategy that minimizes hospitalizations. Since the strategy that minimizes )] TJ ET BT 26.250 154.260 Td /F1 9.8 Tf [(deaths also greatly reduces hospitalizations, it may be preferred by decision makers.)] TJ ET 0.965 0.965 0.965 rg 26.250 -13.871 555.000 158.250 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 144.379 m 581.250 144.379 l 581.250 143.629 l 26.250 143.629 l f q 225.000 0 0 142.500 35.250 -7.871 cm /I12 Do Q q 35.250 -13.871 537.000 0.000 re W n Q Q q 15.000 -13.871 577.500 790.871 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(Our analysis indicates that both deaths and hospitalizations can be minimized by prioritizing the vaccination of school-aged )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(children \(5-17\), young adults \(18-44\), and people at high-risk of severe infections. However, the temporal order of prioritization )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(differs between these two outcome measures when staggered vaccination schedules are considered. Deaths can be minimized )] TJ ET BT 26.250 731.762 Td /F1 9.8 Tf [(by prioritizing high-risk people first, followed by schoolchildren and young adults. In contrast, hospitalizations are optimally )] TJ ET BT 26.250 719.857 Td /F1 9.8 Tf [(averted by first prioritizing schoolchildren and young adults, followed by high-risk people. In contrast to both optimal strategies, )] TJ ET BT 26.250 707.952 Td /F1 9.8 Tf [(the CDC recommends prioritizing high-risk people and people aged 6 months through 24 years )] TJ ET 0.267 0.267 0.267 rg BT 438.090 707.952 Td /F1 9.8 Tf [([4])] TJ ET 0.271 0.267 0.267 rg BT 448.932 707.952 Td /F1 9.8 Tf [( . Both deaths and )] TJ ET BT 26.250 696.048 Td /F1 9.8 Tf [(hospitalizations for the 2009 H1N1 pandemic could be reduced by shifting focus to schoolchildren and young adults.)] TJ ET BT 26.250 659.445 Td /F4 12.0 Tf [(Results)] TJ ET BT 26.250 639.491 Td /F1 9.8 Tf [(To minimize deaths, the optimal policy is for the first two batches of vaccine to be allocated to high-risk people, followed by )] TJ ET BT 26.250 627.586 Td /F1 9.8 Tf [(schoolchildren \(ages 5-17\) and then young adults \(ages 18-44\) \(Figure 1A\). To minimize hospitalizations, the first five batches )] TJ ET BT 26.250 615.681 Td /F1 9.8 Tf [(should be allocated to schoolchildren and young adults, with a small amount of vaccine also allocated to high-risk people in the )] TJ ET BT 26.250 603.777 Td /F1 9.8 Tf [(fifth batch \(Figure 1B\).)] TJ ET 0.965 0.965 0.965 rg 26.250 362.141 555.000 231.755 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 593.896 m 581.250 593.896 l 581.250 593.146 l 26.250 593.146 l f 26.250 362.141 m 581.250 362.141 l 581.250 362.891 l 26.250 362.891 l f q 112.500 0 0 112.500 35.250 471.646 cm /I14 Do Q q 35.250 373.391 537.000 92.255 re W n 0.271 0.267 0.267 rg BT 35.250 456.122 Td /F4 9.8 Tf [(Fig. 1: Optimal vaccine allocation for different vaccine delivery schedules, different values of , and different )] TJ ET BT 35.250 444.217 Td /F4 9.8 Tf [(objectives.)] TJ ET BT 35.250 424.847 Td /F1 9.8 Tf [(The delivery schedule 45M + 4 20M doses corresponds to five batches of vaccine delivery: 45M doses on 15 October )] TJ ET BT 35.250 411.111 Td /F1 9.8 Tf [(and 20M doses each of the following four weeks. The different shades of blue correspond to the optimal allocation of the )] TJ ET BT 35.250 397.375 Td /F1 9.8 Tf [(different delivery batches. The green and red bars indicate the optimal allocations under hypothetical early delivery )] TJ ET BT 35.250 383.638 Td /F1 9.8 Tf [(scenarios of 125M doses on 15 October and prior to the outbreak, respectively.)] TJ ET Q BT 26.250 343.841 Td /F1 9.8 Tf [(As the basic reproductive number \()] TJ ET q 16.500 0 0 13.500 177.434 341.141 cm /I16 Do Q BT 193.934 343.841 Td /F1 9.8 Tf [(\) increases, optimal allocation to minimize deaths no longer includes schoolchildren )] TJ ET BT 26.250 331.617 Td /F1 9.8 Tf [(\(Figure 1C\), while optimal allocation for hospitalizations shifts to include high-risk people \(Figure 1D\). This is due in part to )] TJ ET BT 26.250 318.436 Td /F1 9.8 Tf [(acquired immunity: for )] TJ ET q 47.250 0 0 13.500 124.862 315.736 cm /I18 Do Q BT 172.112 318.436 Td /F1 9.8 Tf [(, only 11% of schoolchildren have been infected before the first vaccine is available on 15 )] TJ ET BT 26.250 304.936 Td /F1 9.8 Tf [(October, whereas, for )] TJ ET q 47.250 0 0 13.500 122.707 302.236 cm /I20 Do Q BT 169.957 304.936 Td /F1 9.8 Tf [(, 45% of schoolchildren have been infected by 15 October.)] TJ ET BT 26.250 292.713 Td /F1 9.8 Tf [(The optimal allocation is sensitive to the scheduling of release times. Consequently, evaluation of each batch separately does )] TJ ET BT 26.250 280.808 Td /F1 9.8 Tf [(not generate the allocation strategy that is optimal overall \(see Text S1 and Figures S3-S10\). For example, when only two total )] TJ ET BT 26.250 268.903 Td /F1 9.8 Tf [(batches are available \(45 million doses on 15 October and 20 million on 22 October\), deaths can be minimized by allocating the )] TJ ET BT 26.250 256.998 Td /F1 9.8 Tf [(first batch to schoolchildren and the second batch to adults aged 18-44 \(Figure S3\). In contrast, when 3 total batches are )] TJ ET BT 26.250 245.094 Td /F1 9.8 Tf [(available \(45 million doses on 15 October and 20 million on each of 22 October and 29 October\), the first two batches are )] TJ ET BT 26.250 233.189 Td /F1 9.8 Tf [(optimally split between schoolchildren and high-risk people and the third batch is used exclusively on high-risk people.)] TJ ET BT 26.250 213.784 Td /F1 9.8 Tf [(The projected reductions in infections, deaths, and hospitalizations are substantial for both sets of optimized vaccination )] TJ ET BT 26.250 201.879 Td /F1 9.8 Tf [(strategies \(Figure 2\). The strategy that minimizes hospitalizations is predicted to reduce the total attack rate more effectively )] TJ ET BT 26.250 189.975 Td /F1 9.8 Tf [(than the strategy that minimizes deaths \(11.4% versus 15.2% of the population infected, respectively\). Comparing the number )] TJ ET BT 26.250 178.070 Td /F1 9.8 Tf [(of deaths and hospitalizations, the strategy that minimizes deaths results in 8000 fewer deaths \(a 23% reduction\) and 44,000 )] TJ ET BT 26.250 166.165 Td /F1 9.8 Tf [(more hospitalizations \(a 9% increase\) than the strategy that minimizes hospitalizations. Since the strategy that minimizes )] TJ ET BT 26.250 154.260 Td /F1 9.8 Tf [(deaths also greatly reduces hospitalizations, it may be preferred by decision makers.)] TJ ET 0.965 0.965 0.965 rg 26.250 -13.871 555.000 158.250 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 144.379 m 581.250 144.379 l 581.250 143.629 l 26.250 143.629 l f q 225.000 0 0 142.500 35.250 -7.871 cm /I22 Do Q q 35.250 -13.871 537.000 0.000 re W n Q Q q 15.000 -13.871 577.500 790.871 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(Our analysis indicates that both deaths and hospitalizations can be minimized by prioritizing the vaccination of school-aged )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(children \(5-17\), young adults \(18-44\), and people at high-risk of severe infections. However, the temporal order of prioritization )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(differs between these two outcome measures when staggered vaccination schedules are considered. Deaths can be minimized )] TJ ET BT 26.250 731.762 Td /F1 9.8 Tf [(by prioritizing high-risk people first, followed by schoolchildren and young adults. In contrast, hospitalizations are optimally )] TJ ET BT 26.250 719.857 Td /F1 9.8 Tf [(averted by first prioritizing schoolchildren and young adults, followed by high-risk people. In contrast to both optimal strategies, )] TJ ET BT 26.250 707.952 Td /F1 9.8 Tf [(the CDC recommends prioritizing high-risk people and people aged 6 months through 24 years )] TJ ET 0.267 0.267 0.267 rg BT 438.090 707.952 Td /F1 9.8 Tf [([4])] TJ ET 0.271 0.267 0.267 rg BT 448.932 707.952 Td /F1 9.8 Tf [( . Both deaths and )] TJ ET BT 26.250 696.048 Td /F1 9.8 Tf [(hospitalizations for the 2009 H1N1 pandemic could be reduced by shifting focus to schoolchildren and young adults.)] TJ ET BT 26.250 659.445 Td /F4 12.0 Tf [(Results)] TJ ET BT 26.250 639.491 Td /F1 9.8 Tf [(To minimize deaths, the optimal policy is for the first two batches of vaccine to be allocated to high-risk people, followed by )] TJ ET BT 26.250 627.586 Td /F1 9.8 Tf [(schoolchildren \(ages 5-17\) and then young adults \(ages 18-44\) \(Figure 1A\). To minimize hospitalizations, the first five batches )] TJ ET BT 26.250 615.681 Td /F1 9.8 Tf [(should be allocated to schoolchildren and young adults, with a small amount of vaccine also allocated to high-risk people in the )] TJ ET BT 26.250 603.777 Td /F1 9.8 Tf [(fifth batch \(Figure 1B\).)] TJ ET 0.965 0.965 0.965 rg 26.250 362.141 555.000 231.755 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 593.896 m 581.250 593.896 l 581.250 593.146 l 26.250 593.146 l f 26.250 362.141 m 581.250 362.141 l 581.250 362.891 l 26.250 362.891 l f q 112.500 0 0 112.500 35.250 471.646 cm /I24 Do Q q 35.250 373.391 537.000 92.255 re W n 0.271 0.267 0.267 rg BT 35.250 456.122 Td /F4 9.8 Tf [(Fig. 1: Optimal vaccine allocation for different vaccine delivery schedules, different values of , and different )] TJ ET BT 35.250 444.217 Td /F4 9.8 Tf [(objectives.)] TJ ET BT 35.250 424.847 Td /F1 9.8 Tf [(The delivery schedule 45M + 4 20M doses corresponds to five batches of vaccine delivery: 45M doses on 15 October )] TJ ET BT 35.250 411.111 Td /F1 9.8 Tf [(and 20M doses each of the following four weeks. The different shades of blue correspond to the optimal allocation of the )] TJ ET BT 35.250 397.375 Td /F1 9.8 Tf [(different delivery batches. The green and red bars indicate the optimal allocations under hypothetical early delivery )] TJ ET BT 35.250 383.638 Td /F1 9.8 Tf [(scenarios of 125M doses on 15 October and prior to the outbreak, respectively.)] TJ ET Q BT 26.250 343.841 Td /F1 9.8 Tf [(As the basic reproductive number \()] TJ ET q 16.500 0 0 13.500 177.434 341.141 cm /I26 Do Q BT 193.934 343.841 Td /F1 9.8 Tf [(\) increases, optimal allocation to minimize deaths no longer includes schoolchildren )] TJ ET BT 26.250 331.617 Td /F1 9.8 Tf [(\(Figure 1C\), while optimal allocation for hospitalizations shifts to include high-risk people \(Figure 1D\). This is due in part to )] TJ ET BT 26.250 318.436 Td /F1 9.8 Tf [(acquired immunity: for )] TJ ET q 47.250 0 0 13.500 124.862 315.736 cm /I28 Do Q BT 172.112 318.436 Td /F1 9.8 Tf [(, only 11% of schoolchildren have been infected before the first vaccine is available on 15 )] TJ ET BT 26.250 304.936 Td /F1 9.8 Tf [(October, whereas, for )] TJ ET q 47.250 0 0 13.500 122.707 302.236 cm /I30 Do Q BT 169.957 304.936 Td /F1 9.8 Tf [(, 45% of schoolchildren have been infected by 15 October.)] TJ ET BT 26.250 292.713 Td /F1 9.8 Tf [(The optimal allocation is sensitive to the scheduling of release times. Consequently, evaluation of each batch separately does )] TJ ET BT 26.250 280.808 Td /F1 9.8 Tf [(not generate the allocation strategy that is optimal overall \(see Text S1 and Figures S3-S10\). For example, when only two total )] TJ ET BT 26.250 268.903 Td /F1 9.8 Tf [(batches are available \(45 million doses on 15 October and 20 million on 22 October\), deaths can be minimized by allocating the )] TJ ET BT 26.250 256.998 Td /F1 9.8 Tf [(first batch to schoolchildren and the second batch to adults aged 18-44 \(Figure S3\). In contrast, when 3 total batches are )] TJ ET BT 26.250 245.094 Td /F1 9.8 Tf [(available \(45 million doses on 15 October and 20 million on each of 22 October and 29 October\), the first two batches are )] TJ ET BT 26.250 233.189 Td /F1 9.8 Tf [(optimally split between schoolchildren and high-risk people and the third batch is used exclusively on high-risk people.)] TJ ET BT 26.250 213.784 Td /F1 9.8 Tf [(The projected reductions in infections, deaths, and hospitalizations are substantial for both sets of optimized vaccination )] TJ ET BT 26.250 201.879 Td /F1 9.8 Tf [(strategies \(Figure 2\). The strategy that minimizes hospitalizations is predicted to reduce the total attack rate more effectively )] TJ ET BT 26.250 189.975 Td /F1 9.8 Tf [(than the strategy that minimizes deaths \(11.4% versus 15.2% of the population infected, respectively\). Comparing the number )] TJ ET BT 26.250 178.070 Td /F1 9.8 Tf [(of deaths and hospitalizations, the strategy that minimizes deaths results in 8000 fewer deaths \(a 23% reduction\) and 44,000 )] TJ ET BT 26.250 166.165 Td /F1 9.8 Tf [(more hospitalizations \(a 9% increase\) than the strategy that minimizes hospitalizations. Since the strategy that minimizes )] TJ ET BT 26.250 154.260 Td /F1 9.8 Tf [(deaths also greatly reduces hospitalizations, it may be preferred by decision makers.)] TJ ET 0.965 0.965 0.965 rg 26.250 -13.871 555.000 158.250 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 144.379 m 581.250 144.379 l 581.250 143.629 l 26.250 143.629 l f q 225.000 0 0 142.500 35.250 -7.871 cm /I32 Do Q q 35.250 -13.871 537.000 0.000 re W n Q Q q 112.500 0 0 112.500 35.250 471.646 cm /I34 Do Q q 225.000 0 0 142.500 35.250 -7.871 cm /I36 Do Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(2)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Influenza)] TJ ET Q endstream endobj 64 0 obj << /Type /Annot /Subtype /Link /A 65 0 R /Border [0 0 0] /H /I /Rect [ 438.0900 707.0506 448.9320 716.9712 ] >> endobj 65 0 obj << /Type /Action >> endobj 66 0 obj << /Type /Annot /Subtype /Link /A 67 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 471.6457 147.7500 584.1457 ] >> endobj 67 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coverage1417.png) >> endobj 68 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 69 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 68 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16058>> stream xitǕ.x#kP EhQ$%,jyd%-R}l=Y2-b[dQ\YI" $ @a) @-#`dDdV̏?߽̈_č7c1Fa!BZ1']Xfӓm6vʺ_;66I&dinnn坝HԩSEEE===pcƍeeeUIDtGGܗ%"0==}…X,}뭷 xމngΜ9e˖P(sss:;;5M.,,BoqpptF"M*++#xhhn ]8[q8hS4%Y+B؝<(UU 9XI$ %mb+3Jt4p8`OOW\ XNabą"N5uttp-@h*`DS5 {yyyp(//zPt|`ܧz#[ÂH8Auuu\3(3E Bqvvxx .l6v~IMMXX1_q9D4 j4JD@3upMTU=uԩSh0we1&֘IUXPjGjX4&v1B.>R?ż_K}iCcf8 꺞JQEQ,8.J4;QW7 ( !zꚚz;k(W334i2KMC/ XӴ^xallw߽? KzBv'7e\)ɣӳnLVrjnn4i   6fzVFTqcgFvm۶׷tM@osVq#+]vO}Pm0W]uU2,))!MvA:N^"t -Z/5XjՓO>jl(n͠`rrO\m7;F]{ythy׆r۷\C[ &XvhiiI$eeeMRk5,\D<\ɲ٪S7#H_*FzEHCrۄh ,[l|||ddT+g.p~gkWqsi5,%(bGG ۬j2F' aK[$&`~trTE;Fx2>Z4g5Y}En19#@H!+yP xYf.\{]q{R#UY%`KJJF|4NX?F"p o:.F{90AR1JQF r(UYZ_QKAq+ŗ BАFd(#.nR<`&L) E Jbr}PQ)}ƪ`k;D"A~NɻhI1gv(Ak@VqƦLGLkD#i333@lO}ܹSʚsQjƈc#ԋ.J4wyOHfClbg,ZTUu\XEoo/@iah fK,f%Ú  š62Ẑ#LV1SSS.k||Tmٲ%HLLL? pB9ϳ1>sL(`0l2HZ94i JFЄ_13w`eq^HZ%% ONN644>+W`HR&$Db``cLI,oy]ZZ^+vnqTqLi %HzXʰPb΢Q1?_%$?0g\γK:y+@ @'X&ϛ(ͩXG{^~yu p`rsK|}b7>5<Z`4ǟ̠2$hX,VZZĴm6.cDY I8򞰸wF&`zz:씋`r@ JSLn- a|wqH0k1'.Z llakl7+ʽmr/]5[1"slvb 3(kƩ[*DE')d2Ft@ qYȬ23ZIr1ΤE3˖%T(4FPKEIJC{Ub+VT*SU\2..Ĕ7%%9Ĭu,[bS;9!?ƶo~=@MÌX)--D"lIb;iN "d)%HNϟ?O߿²UU*@ ې'SU 8HTUU 2бcHjzsaRfˇSm(6JFERʃK )BL m6!J{ttT %"g# Km G8 S /p:!LNNvww5552ßtd\F` )]]Q_WIx|vvݺ[Ki P P nfi @`;hqW}nI,QŠD''h !@@ݛxJ.ѰYBxp8?z ggCYP3d_t{~!9T54'ξ;wx6mڴk׮y()%cќ^D"5nJ09<<( 9 {<%xtR)Fv;yw9":>|D"t:V37$bIو@OOH*i!&ؒ@PP/N[[[;;;UU{2u]߷oO<1>>."`UUwyx?)9X,{Kd_Ig}}}7rJ9_J@$YXx [X8_AQ,B? x^vMnMRT(l?GgΜ)))!->E kꫯnڴOӟg&''_y啢Gyd``t]r{ݳg],E#811Dd% / "p1G]AC=$dMㅅ5k?~|xx8T*E~A)p8뛛[ZZ ׋bnZvnWDD>Bs֤rEQ:`5ўi+^iB, AZsY/j^zm۶u]:bL#Bq?p³P###6l,@+,tV|^,A98&)sNĉgϞY~ng}*ÂW,8Ĭ=Ry˃2# G҂R+nc$n;ݸq;޽{8Zb8dm>-iAםLK|Pd"˿@Ra51ƸnWWWK5r؆b\>!w:!XSS6YF% f7( yJڲ_M,:OX.^wH7&1~rb#E,aI+'/J4^څcaGjc"Lk2\/z`{衇y&qt…Gvбc*++O>]WWJ|Ɂh4:33H$8ۛCu\O?tuufD"6ybbbnn.++yxxbY)w_ƌ 髪={*++ip8<66f>`,l㳳9r$:333::z…x<~h4뺦in?77wrr7߬TU5$#G协;ݻwfeeayk1tb驩:uTee 4Mx<?puuuii)j"hoouo|q\p* F"XrUUUqVa|Ωe+9eRTwwiSSS999~2ܲePUU|<==]SS߿jժq?55USSwM7E"p8\ZZiǣhMM믿(׿Ǐ;vLӴݻ;;;KJJ un?]Id Pqq "HCCC (**c}`0r֮][RRzUUUvvv}}}aa333r plݺ5++~nnirrrʕ\jh=I ;:::00z\r0(277M~h\n盟NLL466VVV"VUUr˓d]]yW ht튢TVVVWW@ PPPPUUH$ zjhfvA^e"mO8JaBI[?!T<]r%tЦV-8fUB;ĄfϟNRLjd13%IEJpIKn=zN`q>ϿNoooo`Ť Ow?6l&Pf9uaMP~(glllbbBd2900x>6ǥ& _\/E@,#eFP i1SdM@qbQڒ[UՁ4M5  ]Ș}) #ccc6l~mbfE(ӴۼA0A2kQ`C.>ȋrY4ABOK"=ىak`ffoowؑ#EO$!AQ0qUUkVC+K՛1u`,Ai [*9Uٳᣣ*M͢~c1{pIFf֥O5~u֑\x?C~^q88 <lEG B`.94H 5AN;B].A)MiLx~_b1 t]F]]]! (͢%2ܿf*t/i/ %UJ7{l ~ץBV1x|͚5tĿavwz2q hHwk@4ic"%HNv8,4JA]uUÇbqq\ҼBQֳrhJc!7$Pi?xXi9000}/pF M/V8aԕ4vdaEi L.T@iyE%CV1ׯoiix34IDk) +P׵H*,%(BeB#<@Ҡe@wwȇ` }6K1!a/D}Aʱ3ߚ! /zv(__$}m6;-D?G\CcoNGlLbr]`2q"+K Ǧj={@OPmaz~ cc?.=o#HjkwtygDVB93Jصu-%BpǙı_VLu%bM/_`7yOU_Y-9ccE+z"'Ge0=P>1Xu\6b]qCT??œcnMGP\R2iIBʍ[[&&;P oK2413muj݇OȅhVȈQquDNNaʵ2͗c'r41,F}JX8%ɳYfJژ-G?C,N 8g8pe, $Dr gt75SqItBIj^,b,r/]w|JMtp<ݺd2IwAD(B^8HjgRR)]R*\a RRd*״*`]]Q.T}ޗ.TFPUUUMjBT]ׁTUU5 TՄ&KJ& zꩼ/| c؏B7F;:]Ԍc-(,=ADf]hl2xfp0Jpaa8p$Iә!AI=~x"(++ BNsƍܖF޶OAN J_!"ƷL%IEJ.U;%RHŏr3߿S?F" ߹%EӴ.$'|MΟ?O+"`ϟ? !pt"AKPj!!(UB VçFHAyzD>k;v>fEQ4McrAJwwf[ni]]]ؘz~>܀|{lllj'SSS:x kE[gzz%ȥT%(JPUUBX:DZm?MMMPhpp0J`&(Fɯ###---㘤{<&_|뭷4M?!= QPEE͛Òe O~1F8ܔ,..s$}666ҁ6#Ho9ߐM)(nٳeddꪪX,_;B^wEEE?!~_o߾f}}/--xW*++gc<66cLJJEEnpBnno|ryZq#5fx'_&>00PVV~Y<0&ԉ "~?!H1XL Hk֬!}E]zi,|% 6^Vib׻gϞ`0}vVt4M&xh4?w}7QjR4M B$iii႗E ǐ% , JBZC7*iB( \!{I.Y5FWFF*'ł 'JoZN*JN)tTLXv2/nfJ旛f4$PGbjAXOt:u]~g j1ַTU%f+r\.H]]MW^YfM*=xڵkcXggm6>>OG?&BlMϸD%\ \sU mߎ~CCC9999sg{-[t:O[Z[[VXAV0KjbbḪj##ʕ+N>=22n:]ק=Z__={>>}P$ɗ뜜###Hdrr窫B6::v~ӧ7o|Ǐoٲkϧ4)V0Dld2u_W`~~}˖-d!=y :3N8aٜN'۷o'N f%ifѾp8F<O$eee///'1SssKhM,6uWmtB( MLLZ|hh( "FFF3%%%HDUղ7|8''GQ[ZZh2 PFQӹu֏>pDђEQE!u\رc.5pQaqNj"b Lp66ڌ4⎛H$.Ù̆=4V堹 ՚R*aK<g?,M+-,Hh>ryT jxD:zI? ,/e{k=#4M{ZZZ0ƿ/o`0zNNÇO8zvÇ7o\ZZz5׼K7o4maarE"ktŕW2z˗NNNE"۝_TTtС꾾믿>%%%}}}?wܙL&WZEvn],S]݉(p(Ά1ƣP윟'3YYY$q:Nɓ@ܹs v= ' FGG{zzzzzVZҲcǎ˗s΋1YFEyyy@ //|}7:0===555===22rlaaann߽{wyy|IIٺuY^{ݻ7lzsrr䲊HJK5;3WDҮ1}ww|HooڵkUUE|>=66FX$iϓ ;;;??Dcǎ555%Ǐn_~}(ztf;vEcvv7D"D"uuueeeNzHNOOa(,,,--=qD0l~?>}:l޼y||c͚5Ν&e J3Jw%)w B!Nx ®i%*m.CVf!F5jF|hF|1ZA,NjW{b(fffu$RUȑ#rMMM999T1k}ʫܹs-;X,WXXxСϟojj*((.--q:.+o޼{hhtb'&&V^H$8r|q8pح0'εYR*+G4EyXXXxwD(z'EyGFF{/EEEo7޸066nݺ˗K.ڵd۶mh?lllp\%%%---c|G-//?}ᨪrjf F xު*˵f͚]vegg? pn 充PhϞ=OɉD"[lYkk={l<]l|nnnkk+9 )pEE3DOR7JRdK(++kv{EEƍ3Q~nn]gffn& %KQ! +++KJJ8m۶h4JnsvZLJاH˵׶WB 7 Unᆱ믿>ɪ*rw󕔔dee]uUnԩSvyB)??ݺuzkGGʕ+UU BW^yeqq(++u}ڵtD$l H#!fenkD~WLą:&dHRl#q"CDjO[CwHl-JPV B: l>V,ȖzQtT02PW48qJU Ξ=iڱcn6]ׯj777Gy񪪪{QrW`PQ˗l6M֢n_XX K̙3`phF~^H&MMM.d8Lfo6뗱h*$(C رX,va =6mժUҾСC_yZy导|wϿb؉'*++TU>qv8w=ٳgO>]TTtɼg6669rdtto|wW^^[T++ۢI:% b endstream endobj 70 0 obj << /Type /XObject /Subtype /Image /Width 22 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 22 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 226>> stream c`0b@|XMb> YsE&qEX\"s.HʝX"<猞Jц TQ{zx@x*q\P;d!'b ps:@eÆ(@r) uS@ ]}CCXx MԹ6< 10AY@@lŴ&X \ jAfXv@CXiJLU([.C endstream endobj 71 0 obj << /Type /XObject /Subtype /Image /Width 22 /Height 18 /SMask 70 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 22 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 18>> stream 8c`` endstream endobj 72 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 391>> stream 8c`0b p@(mftt,[BH d>(k> Ys) 'S0lQJgbhCTƹ6w!~$,`sI H_s3z**E*P-@ 6m NPLTUHy@bR$-cٯqHq"f]0VA\=t@ǎaC!l)++;ה>(!m9%$SŒ)`@(4,@sIcB׀T@I?KO?&s3lxvbaBZ609ZK0```/SX) D?GV$1!_Ҕ"\ =" endstream endobj 73 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /SMask 72 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om_x \ endstream endobj 74 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 383>> stream 8c`0b ul;7c B*fXm%1 `;$k՝5e{)80<.4ܦAx@T߅ oWlK s@R6bAW1猞Jц TA  ~I0SUsSĤ H`ѿ 8${8x|Vt.̹`,{&Gҏd0֜3@r) ufLdDa?`cB׀T@I?KO(@3DaCL CB?вYu$I "Y _p+eapraS#pV VDI ltׯ4%|@C( # endstream endobj 75 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /SMask 74 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om_x \ endstream endobj 76 0 obj << /Type /Annot /Subtype /Link /A 77 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 -7.8705 260.2500 134.6295 ] >> endobj 77 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/impact14.png) >> endobj 78 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 190 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 300 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 409>> stream xA 0 =fy9뀟\| endstream endobj 79 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 190 /SMask 78 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 300 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 32791>> stream x}yxUӝHA@qXePGeܝguFNjuzAP1"!@ }O'w:uͽ{|{oNw5' L /1d:&8Wzsg1@IVY_P|E8>b"iؤJqJLA<H)b؍'_2A'N̛7oo֒%K>9mڴ5kִO:urPbFzqr^.&\~ (ܨ:[^^~ي w\ǎcXd1jPJ_wuק~*YvmvvE{; ,C!U_J _@wԨQ>`}}h|z>xĉ7xc֭>… fd2\ gpz (J/UUU;yyyO<đ#GZZZ~uo)((8|~~>|Gj)n %>|ʕ+9w^qd ^ti\\\ ߿cc#.v \6aaafg}ht:]\\y~{g <ϧO6M <RcXwԨQsmkkX,sn7;::}իW^:"""???LJJ?>''Gn$rB8ظy_8{섄b7t_ױc:AN:uִ4/~ /+.Y@iQ!kiiinn.**-[._\RR2j(F3cƌ.,:} /`0x]J`"8 y)qx} JnIAxw:ތ3on2~;y$/ph4|Er0U_J+t:jjj\./_\tI'N(--Epl6ٳ\(D:;;/_z].WdddZZZmmmEEEFFFZZZMMMTTTkkkvvvEEon:b>39~N(|% }>X,b#8;w堐!YBT޶m۬Y.]T\\\__?x`JJ⮿!]@ +:riZ Ivp&BH Odt/[`0 P߽pAHұXRagڻwocccZZZ=*MġDș@ +E7|3++sa($#+@VPFҥKuuuP'9+' Rr8֭3=2W0.xT#a5SNw}wuן'v?#{98](d 2 x={vDDF( !2] 4j"/*LOO`"KJU$Pҙkמ>}dٞyp(V]]]+V'j4sr-P?7XTThnfvVZq4 6" J$Z #7,aS4|q#֔ꦛnz*ŋb P.fba v@ x *_L\Xs L . tQ c% *i8|g+abg\PQ +8U|XXXQD<0DKJ"F>QB!cMs:%Y (ZBQs=2TkPv `R,g\ vBN93 (B0Pbg@AuJKK?lܸ񔕕?nڴ'Nr>D(pC &SUY"]*..~n*¹s^z5k={_GGVh4Fjjjl,PA("S窠pX|3rDEE^<"qB[nǰbUP8+"EBQX)j 2|v=))iԨQk׮u8Ν;WXa6 ;wɓ'ڵKz&OAAh,--UK,Р4&U"… ǿ+V'lhhxꩧ =}?3XPPq\dd$<1$XXKP8+ؽyAz{{o GGG;N+-#HъRUatA֯_/={lh4O?tgggTT`ǙL& .#n9 } g]NNG}$M\p?񏽽 VS%r5^< +RV^D/o?~ڵ^zi޽ۼyo]TTsN "+R(J-+-Vg Qn8oJ`C!A.œh4cĽ+S&L0Lz7M^^>\c2я|k~y˥^__駟\.2qD+=5""~Ea.]B"A޴4шxRN5\p=Pe "+\Bbg(8}<#TWW?Syyy wqGDDDAA{N7 ^cA$nR1B /`'xҥK>hJJJRRRkkcccz-vq[ 9GQXE(9VG[nG(|"ʈ]A#EU%(Uzuk#F1B)K#;v,`N021OQZ(ăH")^_JpK'`yhdHPDV L 2DVZEPU'VrZBR$yU$;+UQF)J BB ok b\T1(FVEAϞ={3g@!@r.bwΊET TTT+WTWWy[[t_'N1};"A-qɽEJn*YQ@^p8JHٯ9Dp9r)FQBRŊ]v/O6)qI%qHTp(X#xQT|qD>q"#+l III&MڻwovvQ`̶wygҤIW\Ϝ:uj֬Yf/ 'L`7mڔ"x`vXi9KII9|IbccM&rEO v(E#]B|H Oh ɝY,O W^mhh!))vo~SVV/`ǟ;wNWMMMC+y7 ALuo-!@bcbb|>_sssLL R1"i@hD1I]X唲@f rDQ;B@V82111wqGdddootIN MMM}'bbb6l믭V )Gľ`P(PXi{ZOC #Zc({CIF㸾@ p8\.WRRv*NXtwQN"˱+R8s߾}}}}UUUFݍ6'22r*=7!!o/+= BKPjYiAyjư0d@9cdeb)@wejΝt_q08>"g(9dŋ?5y䔔򜜜BćFDD̚58#DI/H帱-\"PXi#Glhh0iiiVU lw&E6U@ ZUp(x_._6xf]DQD\<@ 5EZ( &iȐ!7nlnnÇU̝;o_{1 ~F{L@ Kb 2B-+EVTA)p䐡 8.)))###66ʕ+< ؞@BA!yŠ.Բ4nlp & iHRM @t1S7KG,((=&aUr qF(((nݻ'صk^(kYiÀt(}* gԨQuuuwzn$td/(iIQ ].ׁϟ?/\^VV8%k$s`BL3.E ;{Zv4/7Z(HFXiϝ;|\\ZeAgIbkdBt<1uԸcǎWy9="+9  wh馛f+~kL9&%JQ;ZVѣG{^'>_&':ZfBNj4qСC&&&.YDʍGDK5z@ 7"PX oBv;#TxuRz\w'xG|뭷,Yٳn͕߮;vXىw@!VĨ{N2|[{oVcc%Klܸn]bDHͨ gN8q¿o;vSlPq/qV@h ԩSW^-))L8WӳiӦÇ+Vox< 6tww_v E€RCKiPH/^gUUU&M<رcԩǏ/**,_|흝mmm;vtr ;U>?/W1BYL@ `6z=n`(nh y(JgBeM6L@<`KjpVeee-\033SjZ#B!TŞ4Q  NJEB`8.77?zn:t$oyz{o ̙xb@CCÍF#$ wT|.A[M:o޼$X 'Oo.\iӦO6-..gx O*m%L$S g@PDVZlڵQQQÆ ElAb&‡8R}QRJ 1bĨQ:::ƏoX[;+Vt: Զ YpV TUUlFi q)i+ YiGꫯqqqw_jj*L1)&!Pmءpb˖-ɐ6Er'n@I l?l6[yyyYYYBBBXX>E,P!YkQ vʔ)+V())X,F(bnĀg}"P-ܙ 6YnmZޥK"^Sl3 x3P+*CJ d|:lKLL'B!a>(FiARŊ?{쉍=sLzz- 8r7v/@!٥*aP! L9rdB!YG8,$4(Pa(D <3R@!XQY 0|e˖;V|77x+pVZءB`ŃF"[:m۶ 6X˥o6W_U-? 8\ `>l͛7Ǐ'BQOTղh  a%;jԨW.DA4zהHEw;FP!4x\qqO8q1cƬ[j'O|ŋN.M ,R"ք˗/2dȑ`"`D#|^1U7]*(Uu O~c :hРI&޽;L>>ɉ:tHUB$HdMUPS6TH=pW۷'ǁ8 ^ȬX Ȫe׮]ʼn6-'''**w4֨$P0ڪ@\,Buu3gfsOOObbb !&&d2%$$H Ciii=!5rR$()r$666644\|>%E|ʔ)_z}ff&@3ļ 0{F("#F=q1c Y&n {@U(@dz$R333_|Ԍ3fʕO=zh\bdڲe4>99`07 /^9cjp 0y#GN>}߾}Z^^^LL̂ :;;/ϝ;Ww^{F,,MHUPxK|Sg"#####G!Yv͞=;4brΊE*("Cw})rB ԨW nHq#5'!읂Z(rvmd*!)BnB%PFPxAl#Ģh4CXN(@µJDDDرcqd dMSdEӡ@J )Ry`% 2#\˱|>U &Op(wTBQX/_nY|UFaY&kZU"n,j,;+\}۟O {ܹ3(P" xG"HTy(ڪ|Bx^?糳;^Nљ3Æ#t=eJԺṳ@ṆBN/ $17PDGaeRdEd;k4_IrP+)Jvr M+| D?;=l-*ρX(^DyHCeEBRmJOfbg̣`4rO(e%,;'|C4#c%i0BBYL.Aɑ JNr*`7> vVJ=t) TX C# +]1-MRHB4PD)X( BTIJ(V yˠt֊?%Ixxxtt4Dj[iH92X|RlP]mfJdo֑H uP ~_UQ|{ FӏoR\\\hސ:  sRoh*=ؐX+R!(D+?R$V/~S) de̼a떒p؍(ΐX,(*VDq pIɉGpVH}hH΄Y! .t"Xm@ۦx<1AYmmѣG'7Y D|K^`ؖK 87\o&+|_·؜BAdAhr@,D;6mBtt4 E9=p(|۫k:v>b"&QZ7`?UN+|о=; zwm CʏHbU BXz{wH|ܤeJrȏ>i/tΛu;V X)'p i?uxGOxϪ ](*8hr A#W~/%/܇i PWd MjԑCA0;SXĶ*dVJ N5 xuY<ҥK7l9裏-ZTUUOR.,](B)R!p^ HEa.jL&p8nbq1c6m4hР0qFU 35 $V@ޟT_@X3ɼBwBb555}}} MMM]]]aaaiii TVVHRUJ IL [@YЎ*&C][[kkk{{{-˹sƍes?u <`4,J^HZo2vϷ{<k6GQWW'>[[nOv8%22R|P +2HI{EL̠b&۱cGkkkMM͛oj*AV/{N[lg}VPP )Pm5G6.$8}Ae\n۶r|lNOO_hѶm۲de;W|?hSޒ7*Š-TRBY1cTUUϝ;cРA'O3gd\z XcrŶ+8l6/[硇5L=իRSSlْaAΟ?o0ZZZCE(cX0镈1Eȏ{<$?׮]ϓ'OFFF>_nomm]re~~ܹsIX`CN.u#Y1$,`Aj |EόVw\AxM7M:bpwwssrrTWi=2A 46S8W<%8>Z9 骪\.|T`éEOH'K&ej&KӉ^u:^j>o׮]@`ĉ\cL,F ΊbB"y[W."PUxx}Q%5Ҁ/r?"5^ s;@WПӂk8p\/>>{qqqf…ӦMFf&LHLL.?iIV^%?$}3|؎{MMM7ov:e̘1.`8q &H~RѤ >x[^YzL$"+%-Ed +D ZvܹseΊӧ'%%= %%%1أZ7-g(Baxsrt:mݦh_fggƾtR"< ttVLL @w*M;|AP@ʿ1#""+2:>9I D|~`sg̘!3fLnn|qL^^f9h(@.$TR,LddY'OA)*%x%.J]ª_yz4pw,r/* o eTt2nAxׁ;n[ۀZpإbAPN nBAZIIFVL" :I4DĜtfšZio)JѐBRpoͦ dD T@–*™"$D p_$vTzE2z=B@x8i Ab3-jVž+ਓk*$ sbC ryZ  ҿ C3x+y!,pЯ2)ҭ@W2I ٚ\пTR:Ú85"3ch:qZVD f(8,=Hq&<)OI̱ؠbx\oafa_=c`SҒg Wdz 8ठBH3DT$!n9O1JI)/ҺKǰ`e1(@bJI9埧K^B$gmNgBM BLpVue͠ "V;(SB>)lBjŠ>\j ǯ2 C P~*15YL%ne",@8euUKV  /L RHKLg;q 8"äe&]/пM6QeN Pj @p(A6ĕ#]PXQ"(V@.‘=f /[FR]?G;9aa(.F7Xe:IY sD5q@Vx#bJU8WDRlnc6x 2^X)Ev`Ejle%Px(uO HJLR CIOlI\F,I7&@WFOfIyM: X))^DivdZywY2e )œFD@"9|Yq4ŕ1k#j!i;^EL_Q$ J/I1̓2w $(Fs_q) R F JNH 33m|;1b"쬈LsJ D|=!>Z자6JtW D`{͕28x(bxy<D(y$t=x 7=ˇ@X$9UԝK}9- D|5\#2iqd#5^/$r2$8rGwqY))"@+$~>8d.VHIS,d# NJ¾B; Uڈ {ݴi.\z3fIcbEP;*P,XDN;ym۶={v޽^ߤ0cEU$#$pV 5… O=>~sΝ:@^N}t ͮCU5%<].IQ[N~[=/۱mwl6V;e Dpv?}􈈈]v9}8qٳC\.Wuu袎x@t @EûAmϮ] RYY|z 8 t*P/5]ܾu%[I,zIp+@ 2&)..{ĉ_}մiħDǏ狈>|c,M7%###&&jE͞={̙$TaF.],dX{wjWUtرc䈨(N'Z4i$+sG~X,#>0??j&%%&<<74͡ߪd͡D 66O\!NIMM]bq#ocNg2:;;O:zԔ>}zAAXfwWZ4x+Ë>iӦ 6h4WXX8H\P@A | ?~?_̜93%%巿8{ 7ܠbccYpY Pħ|gGtf{Zd2%)XT%lV^"} |/N(j"ρ@rZ(@ Pnvꟁdi4(} 89YY+]X,DDd'-[SSсa+0ԩS}ݮ.i(!@!sa1x<!CK.stmngÃȶn6^|?u+i"/$xIN`rZQQSON,G ill|SSSV#GbbdH$qEI {}_{ʐ.\_3=zW~) x>^zi[!@}wȑ#[ZZ=syHrϹc Udd{{ʕ+͛WPPk׮#GZVIAVZrGMMݻ'N(>T7(BCtREEŴiÊ܁{iSɓ򦦦,Q˗/:t?SHP>FpΆ_JPDQ~]~ٳSSSGGG!M/%rAjjjZ[[_{5}>CSm82ܸqcFFƸq -5]P?Cjj={dee@ s˖-HII;doozV믿^YYyaDJd"0۽k׮HwUVV;vl6'&&5%Kz###̙h6oޜXRRx?x+kD(ݳgСC^W_}]TTt8iPSN[~ٳw޽xkʹ ;gQvt8iii_~II\*SQQYPPrNgoon7 yyyo`S.oY[[po6''/PL;b588#Twww]]]\\ѣkkk/^|ssT3fzzzbcc͛V5..#@=999''l6WVVjZm4322Բɩ5jСC<7$''[֟ ^DNruVn$Bw}wߝ3gfn6{zzlْ)_tԨÇYfٱGꊎX,_Y46\l3B?O;w5kVllȑ#ZVVp‹/fdd>}zĈdXXY,zu͙3tvvv;wnر C!⻊h;J!@ P\\/VVVN:5..nԨQGX,3gμxȑ# 222.*::z?lٲlٲcǎiڳgt:vTAuG;t)S`[Яjّ>(33fi493 sYt)󍍍UUU-7nh4{{{^ Lp'ct(@GGΝ;_xᅬ!CL8`0!!bɒ%O߻wƝь"##,Xp]w?b͘1 bZ5 I~C<q#?FHs+++;6vzh0jkk#Fx7<qرGzGGGqqE* m;QfsQQS}ܹrAءp' Iat(_RR"fW&$$N j̙8}4qVW^YvmOOυ ](2 G7o>|ԩS7lzO8Р@d ٬P.->>St:ݯ|^1g}СC555p^rҥKFݻ{{{;&@' xvT8b)((4iҕ+Wccc7ohР˟>}:qzb)~ E磣'L}FfsxxxWW?,g>}tuuu~~#P,322~_y商^z5??_#ܾB2!CNjJKKOcǎ(sjZ{zz7cƌȘ3g|aÆ1h4#F̼z3g^}Ճl3gΈq10x  9FFqw/]$7:.33sر'Nܽ{ >sA Yy￟?>hܸqyEEŤIx]DFQ<ۛ[XXwĉ^Fc4Fѣ>~[>裑VD=/:+~Ç.]j*>gΜ>hԩ˗/`7PRΑyd2i4n1cݻw{ޞɤVkAAAVVVzz{1ݾ},Aeaj;;;OfYGyo"kfIn$E'c{HV2hР{W۷ ּ;v|Dp;өju: }F ۼysvvȑ# "" HJw!kHqJWW׆ Ǝe˖NObp8zF|ӟf͚u̙iӦEEE3&99YO 9P ^zt^ܜ;|߶n:yUV-X`ǎw|1 G3ooo_b<駟9:`YP S HA$q'jZV0f̘n󵴴?~U`0̛7/77ˏ?xCCCFF裏 HF6mڔ)S~ᨨk677]xA WQoPM~~ԩSt̙)BEEEy~j~W^MKK{g/_xY8뮨~yʕ.TLD(3^FJF^djEEEv]z.q뮻Ξ=;s̼nZh4&IjjjFۿUWW777竬=@/L_3f5j|gX|Iu:nΜ9s뭷?>77xH♦G=z4 **n_xnh)))PrUh ̊:zY233}>_UUՊ+VkWWj8q\^^^UUUZZZEEENN}---<477WVV^xn]zu޼y}nOHH5^-\hPfJLLxbZZfڸq~h]jkk#""A/M&Sll^| ǎꪩ6mښ5kl6h$~H1X" k+&sgٴZmuu7޸y|paܸqv=ztaaVx衇ĺ}߾} ,ZD-f=vX@YY, S9v΁m@xٽ{#}O8Qaz}KK;wnsssuuwܱwaÆA 1i+j8 ]H BJ`ۘ-8NҴI.ɩݞ&m8icMfua'xcf@$hyLrsJ`פqp8W~o3sg E"kkký񼼼{o͜wH$ӍCCCk׮EywǕn/..KII2,H8N޶m[mmOZZڗ_~ =VD>wf苐 T* d0AAAT*[\_M|+[bp8x<_|… R.{W]sKӂKV4dϞ=B0==FwZ2plvUUUڵk=p566رcp]FS(l6[(߾}駟$  N'{Hhq1o޼)_x4y¸?77W]]-9rĄ:G 4J>}_>~X,~ꩧwx_.a"PI&ܹSPP_ҥK˗/߽{7"B62͵~auu[oG۷q\ %ڵk>>>###v:zƍ333|O(r0\;11zj4t;::R;3==#G, GzK.q8Bqܹ'xbʕP7󄘖(ڍ 0>^zX2;DC&6>#~%Ldt\.g<n+|Lvʕ1PHRI$Rxx8rR333ZFzkE+.^C wҸ(8M '>>ׯ_///h]]],+88|i.?LNN^~hrbzWhgp#t~t7hb+bؘF9pCܹsE8D. +.:fIRp(ߚ5k ^/..+**:wUTd2N# c&^( bt>{]v}>,Ћb0pET*ݾ}kLhd^^^AAAiii###nܼySR8q"55b x/+4>T*V*gϞMNNd7oLHH8|0]~=!8!x.+::GU(큁pΆ`+W޸qcrrl6߽{7<<_W]]ʕ+t !<gN<^ Ɔa|?VfsCC޽{/\&%%aD0?D#h4lȿ]]]sssaaat:=>>>,,lllNdddDRB^fA}0wHI4EPVZZZZR._k! oo^TZl6Nʕ+BFs8)))p? 5 tbXk֬pŽ;fgg>Wਨ(*,Bo=222::j6+L&Jm~~tz}}}dd Ot[{{D_m'x93̎?44gq/bkG@vɹ|#hEEEDDFH$111Ed@@񲲲֮]{;w lf???y3' @wr1g].IHH/** ߿n~&L&3))ܹs fUWWOLLD"___Lܝ#A7(.Vrss333B3<DDDD|'eee6;88٧  @bZ?W^MKK۰arI$cǎgϲ졡!B;ႍ%]|h4\.? ~߆].LSSS]詧 E֋/1( J54G~;\E*:33rkjjyH_/½a@]][(B·z`)%B errR"[bHDMQP xΆӳ{ D65p8JJJƞ|I [LCƹ9<j^p.{Wսj``}a333F 0B3=-B? s}?PNgWWE/Atz<@"Zz6 RJB(w߂\AMMM577D"BS&|f`0AQ %lŷEnk_{ZPO(*1fv}OA`n@D K V<M5 y`b EFC` ]4ڔzM6 0F$a$}[P*Y iz<B%鞔^pL̯ |+P`ov 0e3G; NiB?B o";#XxPfpеLH[o͵O###fƍ,QXXxر|ZmYYYZZZMMZn]{{F u떷wJJJccc?ܕ000PWW'rNW*$d2566666VUU={v˖-y~̙>t7,ˏ~#d!>~`ĎW9w;b 4pn.VJ兜!;22R^^c;w8޽{I$x'NWmll4111充ofFFFee}}}!⫆y׽B9N;Tx[ v0lڴI{f:><<\RR?~9rUUU9sY,~ݮ&B?td2?))ijj 0<<S._t'VpAippppppZZZGGSVV{1:WT_Zmvv பȖhᠻh/z./$Z`VswH$ʪAgddlڴp>5::t:[[[gffӷnjX"""nݚ]@rr-[;;;G:[wv柰x- UmlY%%%gΜyWSSSoܸ{T*-..NIIAXvv=333))G,wwwzF333C"G---FrMOOLx3"""##cvvvbb|]ظq[aBXVw5kքT*???| F#wFxowC# nl6oܸ155r\+VӟuVxܬN 嵶D"Fs84 Ld2X쮂*%rOPn)`_$j՝:ujǎdUUU~~~&I&mٲ%66D&}KsU,--]ltk֬xǏK$1xNѣG)_|! "&Zw 5oD4 OE :?BbѣGһrxF) ˝fvttSGXXdjkk;NNNr\(fffr9zT"=˂ۛu:@!s1G_!>.p8###&[( d&I AAApS lNc}pshZ###| fp\oooOd2R&eppp``@PD"eۜ.Y >7C^$(,11MD#,'ds3DR#}vuc!2h (0߃P=v ‹8!  6B7Z zmB @v?4KCr བ)N'SlL"H㙖P(Z1N'hqBb"Vh,h((x BLwP.A0Z{Mx%yL2L R0cff&::իJ-KKKKBB+^SS#/ގ˕B"m6J{ŵNOO'&&"SSSZ dܱl׮u77S=6o'} khhT644l:^WWt:ccc`JJJOOOOOOjj*Huu͛q&*K&Bp8n߾bVXA(<&zD-=BJ$dP^K\$WE0O^݁ XDOL0I NNN :p^|Š o߾슊Ǐ M@kk\ll,_zݿ/>bppfQԢ".jJKKsrr}]ј-++{e޽d2j5\KRihhhSSh\lGd2+|"22H**++ܹr'''\ܺuϟO^ZVVlwYzu}}zᇵZmgggHH\./--NLLlmmPTAAA333MMMQQQ˗/t]]]l0v`p:aaa:VNaÆ^GRϞ=j*oH$P(h4"N'$$TTTLOO x$lbGd28q"00BRfdd={6 ??߾}rO>d4MVs8ӧOL&8;UZZT* EAAMN<)J1ccc^z ik印KIhE8c4`1'w=X|`p@} q_8(7\VV&NVݷoɓ'ɗ/_H$W^y7|w?99rrss漼V+eXd\.՜˵}v\yڵΝ %t:c=`0wd2aꂇ;ζ6F(4`y=LFL8v믿nݺ;wd2YaaU3zuvٺukrr2ikk3&IȹBؽ{w\\ŋz=BǕӲ}ѡ`^ {fggߴׯܺunٶm[```oooww7NjpӧW\ &HcĎa^07q~0'<p5_z322'&&Zm]]J*&%%XH_rbܹ Юvի%%%~iZZZkkkTTT~~~yy\.H$p) 444;;fh4TzŎ۷LwT*.)JTT۷<}vvvj 6 3l۷o766^x133wޑ卍B'** qFZDppӧ+**`0DEE 7oō*⺺:@/YfM{{{ll7\p/HΟ??<> endobj 81 0 obj << /Type /Action >> endobj 82 0 obj << /Type /Annot /Subtype /Link /A 83 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 471.6457 147.7500 584.1457 ] >> endobj 83 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coverage1417.png) >> endobj 84 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 85 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 84 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16058>> stream xitǕ.x#kP EhQ$%,jyd%-R}l=Y2-b[dQ\YI" $ @a) @-#`dDdV̏?߽̈_č7c1Fa!BZ1']Xfӓm6vʺ_;66I&dinnn坝HԩSEEE===pcƍeeeUIDtGGܗ%"0==}…X,}뭷 xމngΜ9e˖P(sss:;;5M.,,BoqpptF"M*++#xhhn ]8[q8hS4%Y+B؝<(UU 9XI$ %mb+3Jt4p8`OOW\ XNabą"N5uttp-@h*`DS5 {yyyp(//zPt|`ܧz#[ÂH8Auuu\3(3E Bqvvxx .l6v~IMMXX1_q9D4 j4JD@3upMTU=uԩSh0we1&֘IUXPjGjX4&v1B.>R?ż_K}iCcf8 꺞JQEQ,8.J4;QW7 ( !zꚚz;k(W334i2KMC/ XӴ^xallw߽? KzBv'7e\)ɣӳnLVrjnn4i   6fzVFTqcgFvm۶׷tM@osVq#+]vO}Pm0W]uU2,))!MvA:N^"t -Z/5XjՓO>jl(n͠`rrO\m7;F]{ythy׆r۷\C[ &XvhiiI$eeeMRk5,\D<\ɲ٪S7#H_*FzEHCrۄh ,[l|||ddT+g.p~gkWqsi5,%(bGG ۬j2F' aK[$&`~trTE;Fx2>Z4g5Y}En19#@H!+yP xYf.\{]q{R#UY%`KJJF|4NX?F"p o:.F{90AR1JQF r(UYZ_QKAq+ŗ BАFd(#.nR<`&L) E Jbr}PQ)}ƪ`k;D"A~NɻhI1gv(Ak@VqƦLGLkD#i333@lO}ܹSʚsQjƈc#ԋ.J4wyOHfClbg,ZTUu\XEoo/@iah fK,f%Ú  š62Ẑ#LV1SSS.k||Tmٲ%HLLL? pB9ϳ1>sL(`0l2HZ94i JFЄ_13w`eq^HZ%% ONN644>+W`HR&$Db``cLI,oy]ZZ^+vnqTqLi %HzXʰPb΢Q1?_%$?0g\γK:y+@ @'X&ϛ(ͩXG{^~yu p`rsK|}b7>5<Z`4ǟ̠2$hX,VZZĴm6.cDY I8򞰸wF&`zz:씋`r@ JSLn- a|wqH0k1'.Z llakl7+ʽmr/]5[1"slvb 3(kƩ[*DE')d2Ft@ qYȬ23ZIr1ΤE3˖%T(4FPKEIJC{Ub+VT*SU\2..Ĕ7%%9Ĭu,[bS;9!?ƶo~=@MÌX)--D"lIb;iN "d)%HNϟ?O߿²UU*@ ې'SU 8HTUU 2бcHjzsaRfˇSm(6JFERʃK )BL m6!J{ttT %"g# Km G8 S /p:!LNNvww5552ßtd\F` )]]Q_WIx|vvݺ[Ki P P nfi @`;hqW}nI,QŠD''h !@@ݛxJ.ѰYBxp8?z ggCYP3d_t{~!9T54'ξ;wx6mڴk׮y()%cќ^D"5nJ09<<( 9 {<%xtR)Fv;yw9":>|D"t:V37$bIو@OOH*i!&ؒ@PP/N[[[;;;UU{2u]߷oO<1>>."`UUwyx?)9X,{Kd_Ig}}}7rJ9_J@$YXx [X8_AQ,B? x^vMnMRT(l?GgΜ)))!->E kꫯnڴOӟg&''_y啢Gyd``t]r{ݳg],E#811Dd% / "p1G]AC=$dMㅅ5k?~|xx8T*E~A)p8뛛[ZZ ׋bnZvnWDD>Bs֤rEQ:`5ўi+^iB, AZsY/j^zm۶u]:bL#Bq?p³P###6l,@+,tV|^,A98&)sNĉgϞY~ng}*ÂW,8Ĭ=Ry˃2# G҂R+nc$n;ݸq;޽{8Zb8dm>-iAםLK|Pd"˿@Ra51ƸnWWWK5r؆b\>!w:!XSS6YF% f7( yJڲ_M,:OX.^wH7&1~rb#E,aI+'/J4^څcaGjc"Lk2\/z`{衇y&qt…Gvбc*++O>]WWJ|Ɂh4:33H$8ۛCu\O?tuufD"6ybbbnn.++yxxbY)w_ƌ 髪={*++ip8<66f>`,l㳳9r$:333::z…x<~h4뺦in?77wrr7߬TU5$#G协;ݻwfeeayk1tb驩:uTee 4Mx<?puuuii)j"hoouo|q\p* F"XrUUUqVa|Ωe+9eRTwwiSSS999~2ܲePUU|<==]SS߿jժq?55USSwM7E"p8\ZZiǣhMM믿(׿Ǐ;vLӴݻ;;;KJJ un?]Id Pqq "HCCC (**c}`0r֮][RRzUUUvvv}}}aa333r plݺ5++~nnirrrʕ\jh=I ;:::00z\r0(277M~h\n盟NLL466VVV"VUUr˓d]]yW ht튢TVVVWW@ PPPPUUH$ zjhfvA^e"mO8JaBI[?!T<]r%tЦV-8fUB;ĄfϟNRLjd13%IEJpIKn=zN`q>ϿNoooo`Ť Ow?6l&Pf9uaMP~(glllbbBd2900x>6ǥ& _\/E@,#eFP i1SdM@qbQڒ[UՁ4M5  ]Ș}) #ccc6l~mbfE(ӴۼA0A2kQ`C.>ȋrY4ABOK"=ىak`ffoowؑ#EO$!AQ0qUUkVC+K՛1u`,Ai [*9Uٳᣣ*M͢~c1{pIFf֥O5~u֑\x?C~^q88 <lEG B`.94H 5AN;B].A)MiLx~_b1 t]F]]]! (͢%2ܿf*t/i/ %UJ7{l ~ץBV1x|͚5tĿavwz2q hHwk@4ic"%HNv8,4JA]uUÇbqq\ҼBQֳrhJc!7$Pi?xXi9000}/pF M/V8aԕ4vdaEi L.T@iyE%CV1ׯoiix34IDk) +P׵H*,%(BeB#<@Ҡe@wwȇ` }6K1!a/D}Aʱ3ߚ! /zv(__$}m6;-D?G\CcoNGlLbr]`2q"+K Ǧj={@OPmaz~ cc?.=o#HjkwtygDVB93Jصu-%BpǙı_VLu%bM/_`7yOU_Y-9ccE+z"'Ge0=P>1Xu\6b]qCT??œcnMGP\R2iIBʍ[[&&;P oK2413muj݇OȅhVȈQquDNNaʵ2͗c'r41,F}JX8%ɳYfJژ-G?C,N 8g8pe, $Dr gt75SqItBIj^,b,r/]w|JMtp<ݺd2IwAD(B^8HjgRR)]R*\a RRd*״*`]]Q.T}ޗ.TFPUUUMjBT]ׁTUU5 TՄ&KJ& zꩼ/| c؏B7F;:]Ԍc-(,=ADf]hl2xfp0Jpaa8p$Iә!AI=~x"(++ BNsƍܖF޶OAN J_!"ƷL%IEJ.U;%RHŏr3߿S?F" ߹%EӴ.$'|MΟ?O+"`ϟ? !pt"AKPj!!(UB VçFHAyzD>k;v>fEQ4McrAJwwf[ni]]]ؘz~>܀|{lllj'SSS:x kE[gzz%ȥT%(JPUUBX:DZm?MMMPhpp0J`&(Fɯ###---㘤{<&_|뭷4M?!= QPEE͛Òe O~1F8ܔ,..s$}666ҁ6#Ho9ߐM)(nٳeddꪪX,_;B^wEEE?!~_o߾f}}/--xW*++gc<66cLJJEEnpBnno|ryZq#5fx'_&>00PVV~Y<0&ԉ "~?!H1XL Hk֬!}E]zi,|% 6^Vib׻gϞ`0}vVt4M&xh4?w}7QjR4M B$iii႗E ǐ% , JBZC7*iB( \!{I.Y5FWFF*'ł 'JoZN*JN)tTLXv2/nfJ旛f4$PGbjAXOt:u]~g j1ַTU%f+r\.H]]MW^YfM*=xڵkcXggm6>>OG?&BlMϸD%\ \sU mߎ~CCC9999sg{-[t:O[Z[[VXAV0KjbbḪj##ʕ+N>=22n:]ק=Z__={>>}P$ɗ뜜###Hdrr窫B6::v~ӧ7o|Ǐoٲkϧ4)V0Dld2u_W`~~}˖-d!=y :3N8aٜN'۷o'N f%ifѾp8F<O$eee///'1SssKhM,6uWmtB( MLLZ|hh( "FFF3%%%HDUղ7|8''GQ[ZZh2 PFQӹu֏>pDђEQE!u\رc.5pQaqNj"b Lp66ڌ4⎛H$.Ù̆=4V堹 ՚R*aK<g?,M+-,Hh>ryT jxD:zI? ,/e{k=#4M{ZZZ0ƿ/o`0zNNÇO8zvÇ7o\ZZz5׼K7o4maarE"ktŕW2z˗NNNE"۝_TTtС꾾믿>%%%}}}?wܙL&WZEvn],S]݉(p(Ά1ƣP윟'3YYY$q:Nɓ@ܹs v= ' FGG{zzzzzVZҲcǎ˗s΋1YFEyyy@ //|}7:0===555===22rlaaann߽{wyy|IIٺuY^{ݻ7lzsrr䲊HJK5;3WDҮ1}ww|HooڵkUUE|>=66FX$iϓ ;;;??Dcǎ555%Ǐn_~}(ztf;vEcvv7D"D"uuueeeNzHNOOa(,,,--=qD0l~?>}:l޼y||c͚5Ν&e J3Jw%)w B!Nx ®i%*m.CVf!F5jF|hF|1ZA,NjW{b(fffu$RUȑ#rMMM999T1k}ʫܹs-;X,WXXxСϟojj*((.--q:.+o޼{hhtb'&&V^H$8r|q8pح0'εYR*+G4EyXXXxwD(z'EyGFF{/EEEo7޸066nݺ˗K.ڵd۶mh?lllp\%%%---c|G-//?}ᨪrjf F xު*˵f͚]vegg? pn 充PhϞ=OɉD"[lYkk={l<]l|nnnkk+9 )pEE3DOR7JRdK(++kv{EEƍ3Q~nn]gffn& %KQ! +++KJJ8m۶h4JnsvZLJاH˵׶WB 7 Unᆱ믿>ɪ*rw󕔔dee]uUnԩSvyB)??ݺuzkGGʕ+UU BW^yeqq(++u}ڵtD$l H#!fenkD~WLą:&dHRl#q"CDjO[CwHl-JPV B: l>V,ȖzQtT02PW48qJU Ξ=iڱcn6]ׯj777Gy񪪪{QrW`PQ˗l6M֢n_XX K̙3`phF~^H&MMM.d8Lfo6뗱h*$(C رX,va =6mժUҾСC_yZy导|wϿb؉'*++TU>qv8w=ٳgO>]TTtɼg6669rdtto|wW^^[T++ۢI:% b endstream endobj 86 0 obj << /Type /XObject /Subtype /Image /Width 22 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 22 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 226>> stream c`0b@|XMb> YsE&qEX\"s.HʝX"<猞Jц TQ{zx@x*q\P;d!'b ps:@eÆ(@r) uS@ ]}CCXx MԹ6< 10AY@@lŴ&X \ jAfXv@CXiJLU([.C endstream endobj 87 0 obj << /Type /XObject /Subtype /Image /Width 22 /Height 18 /SMask 86 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 22 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 18>> stream 8c`` endstream endobj 88 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 391>> stream 8c`0b p@(mftt,[BH d>(k> Ys) 'S0lQJgbhCTƹ6w!~$,`sI H_s3z**E*P-@ 6m NPLTUHy@bR$-cٯqHq"f]0VA\=t@ǎaC!l)++;ה>(!m9%$SŒ)`@(4,@sIcB׀T@I?KO?&s3lxvbaBZ609ZK0```/SX) D?GV$1!_Ҕ"\ =" endstream endobj 89 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /SMask 88 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om_x \ endstream endobj 90 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 383>> stream 8c`0b ul;7c B*fXm%1 `;$k՝5e{)80<.4ܦAx@T߅ oWlK s@R6bAW1猞Jц TA  ~I0SUsSĤ H`ѿ 8${8x|Vt.̹`,{&Gҏd0֜3@r) ufLdDa?`cB׀T@I?KO(@3DaCL CB?вYu$I "Y _p+eapraS#pV VDI ltׯ4%|@C( # endstream endobj 91 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /SMask 90 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om_x \ endstream endobj 92 0 obj << /Type /Annot /Subtype /Link /A 93 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 -7.8705 260.2500 134.6295 ] >> endobj 93 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/impact14.png) >> endobj 94 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 190 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 300 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 409>> stream xA 0 =fy9뀟\| endstream endobj 95 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 190 /SMask 94 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 300 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 32791>> stream x}yxUӝHA@qXePGeܝguFNjuzAP1"!@ }O'w:uͽ{|{oNw5' L /1d:&8Wzsg1@IVY_P|E8>b"iؤJqJLA<H)b؍'_2A'N̛7oo֒%K>9mڴ5kִO:urPbFzqr^.&\~ (ܨ:[^^~ي w\ǎcXd1jPJ_wuק~*YvmvvE{; ,C!U_J _@wԨQ>`}}h|z>xĉ7xc֭>… fd2\ gpz (J/UUU;yyyO<đ#GZZZ~uo)((8|~~>|Gj)n %>|ʕ+9w^qd ^ti\\\ ߿cc#.v \6aaafg}ht:]\\y~{g <ϧO6M <RcXwԨQsmkkX,sn7;::}իW^:"""???LJJ?>''Gn$rB8ظy_8{섄b7t_ױc:AN:uִ4/~ /+.Y@iQ!kiiinn.**-[._\RR2j(F3cƌ.,:} /`0x]J`"8 y)qx} JnIAxw:ތ3on2~;y$/ph4|Er0U_J+t:jjj\./_\tI'N(--Epl6ٳ\(D:;;/_z].WdddZZZmmmEEEFFFZZZMMMTTTkkkvvvEEon:b>39~N(|% }>X,b#8;w堐!YBT޶m۬Y.]T\\\__?x`JJ⮿!]@ +:riZ Ivp&BH Odt/[`0 P߽pAHұXRagڻwocccZZZ=*MġDș@ +E7|3++sa($#+@VPFҥKuuuP'9+' Rr8֭3=2W0.xT#a5SNw}wuן'v?#{98](d 2 x={vDDF( !2] 4j"/*LOO`"KJU$Pҙkמ>}dٞyp(V]]]+V'j4sr-P?7XTThnfvVZq4 6" J$Z #7,aS4|q#֔ꦛnz*ŋb P.fba v@ x *_L\Xs L . tQ c% *i8|g+abg\PQ +8U|XXXQD<0DKJ"F>QB!cMs:%Y (ZBQs=2TkPv `R,g\ vBN93 (B0Pbg@AuJKK?lܸ񔕕?nڴ'Nr>D(pC &SUY"]*..~n*¹s^z5k={_GGVh4Fjjjl,PA("S窠pX|3rDEE^<"qB[nǰbUP8+"EBQX)j 2|v=))iԨQk׮u8Ν;WXa6 ;wɓ'ڵKz&OAAh,--UK,Р4&U"… ǿ+V'lhhxꩧ =}?3XPPq\dd$<1$XXKP8+ؽyAz{{o GGG;N+-#HъRUatA֯_/={lh4O?tgggTT`ǙL& .#n9 } g]NNG}$M\p?񏽽 VS%r5^< +RV^D/o?~ڵ^zi޽ۼyo]TTsN "+R(J-+-Vg Qn8oJ`C!A.œh4cĽ+S&L0Lz7M^^>\c2я|k~y˥^__駟\.2qD+=5""~Ea.]B"A޴4шxRN5\p=Pe "+\Bbg(8}<#TWW?Syyy wqGDDDAA{N7 ^cA$nR1B /`'xҥK>hJJJRRRkkcccz-vq[ 9GQXE(9VG[nG(|"ʈ]A#EU%(Uzuk#F1B)K#;v,`N021OQZ(ăH")^_JpK'`yhdHPDV L 2DVZEPU'VrZBR$yU$;+UQF)J BB ok b\T1(FVEAϞ={3g@!@r.bwΊET TTT+WTWWy[[t_'N1};"A-qɽEJn*YQ@^p8JHٯ9Dp9r)FQBRŊ]v/O6)qI%qHTp(X#xQT|qD>q"#+l III&MڻwovvQ`̶wygҤIW\Ϝ:uj֬Yf/ 'L`7mڔ"x`vXi9KII9|IbccM&rEO v(E#]B|H Oh ɝY,O W^mhh!))vo~SVV/`ǟ;wNWMMMC+y7 ALuo-!@bcbb|>_sssLL R1"i@hD1I]X唲@f rDQ;B@V82111wqGdddootIN MMM}'bbb6l믭V )Gľ`P(PXi{ZOC #Zc({CIF㸾@ p8\.WRRv*NXtwQN"˱+R8s߾}}}}UUUFݍ6'22r*=7!!o/+= BKPjYiAyjư0d@9cdeb)@wejΝt_q08>"g(9dŋ?5y䔔򜜜BćFDD̚58#DI/H帱-\"PXi#Glhh0iiiVU lw&E6U@ ZUp(x_._6xf]DQD\<@ 5EZ( &iȐ!7nlnnÇU̝;o_{1 ~F{L@ Kb 2B-+EVTA)p䐡 8.)))###66ʕ+< ؞@BA!yŠ.Բ4nlp & iHRM @t1S7KG,((=&aUr qF(((nݻ'صk^(kYiÀt(}* gԨQuuuwzn$td/(iIQ ].ׁϟ?/\^VV8%k$s`BL3.E ;{Zv4/7Z(HFXiϝ;|\\ZeAgIbkdBt<1uԸcǎWy9="+9  wh馛f+~kL9&%JQ;ZVѣG{^'>_&':ZfBNj4qСC&&&.YDʍGDK5z@ 7"PX oBv;#TxuRz\w'xG|뭷,Yٳn͕߮;vXىw@!VĨ{N2|[{oVcc%Klܸn]bDHͨ gN8q¿o;vSlPq/qV@h ԩSW^-))L8WӳiӦÇ+Vox< 6tww_v E€RCKiPH/^gUUU&M<رcԩǏ/**,_|흝mmm;vtr ;U>?/W1BYL@ `6z=n`(nh y(JgBeM6L@<`KjpVeee-\033SjZ#B!TŞ4Q  NJEB`8.77?zn:t$oyz{o ̙xb@CCÍF#$ wT|.A[M:o޼$X 'Oo.\iӦO6-..gx O*m%L$S g@PDVZlڵQQQÆ ElAb&‡8R}QRJ 1bĨQ:::ƏoX[;+Vt: Զ YpV TUUlFi q)i+ YiGꫯqqqw_jj*L1)&!Pmءpb˖-ɐ6Er'n@I l?l6[yyyYYYBBBXX>E,P!YkQ vʔ)+V())X,F(bnĀg}"P-ܙ 6YnmZޥK"^Sl3 x3P+*CJ d|:lKLL'B!a>(FiARŊ?{쉍=sLzz- 8r7v/@!٥*aP! L9rdB!YG8,$4(Pa(D <3R@!XQY 0|e˖;V|77x+pVZءB`ŃF"[:m۶ 6X˥o6W_U-? 8\ `>l͛7Ǐ'BQOTղh  a%;jԨW.DA4zהHEw;FP!4x\qqO8q1cƬ[j'O|ŋN.M ,R"ք˗/2dȑ`"`D#|^1U7]*(Uu O~c :hРI&޽;L>>ɉ:tHUB$HdMUPS6TH=pW۷'ǁ8 ^ȬX Ȫe׮]ʼn6-'''**w4֨$P0ڪ@\,Buu3gfsOOObbb !&&d2%$$H Ciii=!5rR$()r$666644\|>%E|ʔ)_z}ff&@3ļ 0{F("#F=q1c Y&n {@U(@dz$R333_|Ԍ3fʕO=zh\bdڲe4>99`07 /^9cjp 0y#GN>}߾}Z^^^LL̂ :;;/ϝ;Ww^{F,,MHUPxK|Sg"#####G!Yv͞=;4brΊE*("Cw})rB ԨW nHq#5'!읂Z(rvmd*!)BnB%PFPxAl#Ģh4CXN(@µJDDDرcqd dMSdEӡ@J )Ry`% 2#\˱|>U &Op(wTBQX/_nY|UFaY&kZU"n,j,;+\}۟O {ܹ3(P" xG"HTy(ڪ|Bx^?糳;^Nљ3Æ#t=eJԺṳ@ṆBN/ $17PDGaeRdEd;k4_IrP+)Jvr M+| D?;=l-*ρX(^DyHCeEBRmJOfbg̣`4rO(e%,;'|C4#c%i0BBYL.Aɑ JNr*`7> vVJ=t) TX C# +]1-MRHB4PD)X( BTIJ(V yˠt֊?%Ixxxtt4Dj[iH92X|RlP]mfJdo֑H uP ~_UQ|{ FӏoR\\\hސ:  sRoh*=ؐX+R!(D+?R$V/~S) de̼a떒p؍(ΐX,(*VDq pIɉGpVH}hH΄Y! .t"Xm@ۦx<1AYmmѣG'7Y D|K^`ؖK 87\o&+|_·؜BAdAhr@,D;6mBtt4 E9=p(|۫k:v>b"&QZ7`?UN+|о=; zwm CʏHbU BXz{wH|ܤeJrȏ>i/tΛu;V X)'p i?uxGOxϪ ](*8hr A#W~/%/܇i PWd MjԑCA0;SXĶ*dVJ N5 xuY<ҥK7l9裏-ZTUUOR.,](B)R!p^ HEa.jL&p8nbq1c6m4hР0qFU 35 $V@ޟT_@X3ɼBwBb555}}} MMM]]]aaaiii TVVHRUJ IL [@YЎ*&C][[kkk{{{-˹sƍes?u <`4,J^HZo2vϷ{<k6GQWW'>[[nOv8%22R|P +2HI{EL̠b&۱cGkkkMM͛oj*AV/{N[lg}VPP )Pm5G6.$8}Ae\n۶r|lNOO_hѶm۲de;W|?hSޒ7*Š-TRBY1cTUUϝ;cРA'O3gd\z XcrŶ+8l6/[硇5L=իRSSlْaAΟ?o0ZZZCE(cX0镈1Eȏ{<$?׮]ϓ'OFFF>_nomm]re~~ܹsIX`CN.u#Y1$,`Aj |EόVw\AxM7M:bpwwssrrTWi=2A 46S8W<%8>Z9 骪\.|T`éEOH'K&ej&KӉ^u:^j>o׮]@`ĉ\cL,F ΊbB"y[W."PUxx}Q%5Ҁ/r?"5^ s;@WПӂk8p\/>>{qqqf…ӦMFf&LHLL.?iIV^%?$}3|؎{MMM7ov:e̘1.`8q &H~RѤ >x[^YzL$"+%-Ed +D ZvܹseΊӧ'%%= %%%1أZ7-g(Baxsrt:mݦh_fggƾtR"< ttVLL @w*M;|AP@ʿ1#""+2:>9I D|~`sg̘!3fLnn|qL^^f9h(@.$TR,LddY'OA)*%x%.J]ª_yz4pw,r/* o eTt2nAxׁ;n[ۀZpإbAPN nBAZIIFVL" :I4DĜtfšZio)JѐBRpoͦ dD T@–*™"$D p_$vTzE2z=B@x8i Ab3-jVž+ਓk*$ sbC ryZ  ҿ C3x+y!,pЯ2)ҭ@W2I ٚ\пTR:Ú85"3ch:qZVD f(8,=Hq&<)OI̱ؠbx\oafa_=c`SҒg Wdz 8ठBH3DT$!n9O1JI)/ҺKǰ`e1(@bJI9埧K^B$gmNgBM BLpVue͠ "V;(SB>)lBjŠ>\j ǯ2 C P~*15YL%ne",@8euUKV  /L RHKLg;q 8"äe&]/пM6QeN Pj @p(A6ĕ#]PXQ"(V@.‘=f /[FR]?G;9aa(.F7Xe:IY sD5q@Vx#bJU8WDRlnc6x 2^X)Ev`Ejle%Px(uO HJLR CIOlI\F,I7&@WFOfIyM: X))^DivdZywY2e )œFD@"9|Yq4ŕ1k#j!i;^EL_Q$ J/I1̓2w $(Fs_q) R F JNH 33m|;1b"쬈LsJ D|=!>Z자6JtW D`{͕28x(bxy<D(y$t=x 7=ˇ@X$9UԝK}9- D|5\#2iqd#5^/$r2$8rGwqY))"@+$~>8d.VHIS,d# NJ¾B; Uڈ {ݴi.\z3fIcbEP;*P,XDN;ym۶={v޽^ߤ0cEU$#$pV 5… O=>~sΝ:@^N}t ͮCU5%<].IQ[N~[=/۱mwl6V;e Dpv?}􈈈]v9}8qٳC\.Wuu袎x@t @EûAmϮ] RYY|z 8 t*P/5]ܾu%[I,zIp+@ 2&)..{ĉ_}մiħDǏ狈>|c,M7%###&&jE͞={̙$TaF.],dX{wjWUtرc䈨(N'Z4i$+sG~X,#>0??j&%%&<<74͡ߪd͡D 66O\!NIMM]bq#ocNg2:;;O:zԔ>}zAAXfwWZ4x+Ë>iӦ 6h4WXX8H\P@A | ?~?_̜93%%巿8{ 7ܠbccYpY Pħ|gGtf{Zd2%)XT%lV^"} |/N(j"ρ@rZ(@ Pnvꟁdi4(} 89YY+]X,DDd'-[SSсa+0ԩS}ݮ.i(!@!sa1x<!CK.stmngÃȶn6^|?u+i"/$xIN`rZQQSON,G ill|SSSV#GbbdH$qEI {}_{ʐ.\_3=zW~) x>^zi[!@}wȑ#[ZZ=syHrϹc Udd{{ʕ+͛WPPk׮#GZVIAVZrGMMݻ'N(>T7(BCtREEŴiÊ܁{iSɓ򦦦,Q˗/:t?SHP>FpΆ_JPDQ~]~ٳSSSGGG!M/%rAjjjZ[[_{5}>CSm82ܸqcFFƸq -5]P?Cjj={dee@ s˖-HII;doozV믿^YYyaDJd"0۽k׮HwUVV;vl6'&&5%Kz###̙h6oޜXRRx?x+kD(ݳgСC^W_}]TTt8iPSN[~ٳw޽xkʹ ;gQvt8iii_~II\*SQQYPPrNgoon7 yyyo`S.oY[[po6''/PL;b588#Twww]]]\\ѣkkk/^|ssT3fzzzbcc͛V5..#@=999''l6WVVjZm4322Բɩ5jСC<7$''[֟ ^DNruVn$Bw}wߝ3gfn6{zzlْ)_tԨÇYfٱGꊎX,_Y46\l3B?O;w5kVllȑ#ZVVp‹/fdd>}zĈdXXY,zu͙3tvvv;wnر C!⻊h;J!@ P\\/VVVN:5..nԨQGX,3gμxȑ# 222.*::z?lٲlٲcǎiڳgt:vTAuG;t)S`[Яjّ>(33fi493 sYt)󍍍UUU-7nh4{{{^ Lp'ct(@GGΝ;_xᅬ!CL8`0!!bɒ%O߻wƝь"##,Xp]w?b͘1 bZ5 I~C<q#?FHs+++;6vzh0jkk#Fx7<qرGzGGGqqE* m;QfsQQS}ܹrAءp' Iat(_RR"fW&$$N j̙8}4qVW^YvmOOυ ](2 G7o>|ԩS7lzO8Р@d ٬P.->>St:ݯ|^1g}СC555p^rҥKFݻ{{{;&@' xvT8b)((4iҕ+Wccc7ohР˟>}:qzb)~ E磣'L}FfsxxxWW?,g>}tuuu~~#P,322~_y商^z5??_#ܾB2!CNjJKKOcǎ(sjZ{zz7cƌȘ3g|aÆ1h4#F̼z3g^}Ճl3gΈq10x  9FFqw/]$7:.33sر'Nܽ{ >sA Yy￟?>hܸqyEEŤIx]DFQ<ۛ[XXwĉ^Fc4Fѣ>~[>裑VD=/:+~Ç.]j*>gΜ>hԩ˗/`7PRΑyd2i4n1cݻw{ޞɤVkAAAVVVzz{1ݾ},Aeaj;;;OfYGyo"kfIn$E'c{HV2hР{W۷ ּ;v|Dp;өju: }F ۼysvvȑ# "" HJw!kHqJWW׆ Ǝe˖NObp8zF|ӟf͚u̙iӦEEE3&99YO 9P ^zt^ܜ;|߶n:yUV-X`ǎw|1 G3ooo_b<駟9:`YP S HA$q'jZV0f̘n󵴴?~U`0̛7/77ˏ?xCCCFF裏 HF6mڔ)S~ᨨk677]xA WQoPM~~ԩSt̙)BEEEy~j~W^MKK{g/_xY8뮨~yʕ.TLD(3^FJF^djEEEv]z.q뮻Ξ=;s̼nZh4&IjjjFۿUWW777竬=@/L_3f5j|gX|Iu:nΜ9s뭷?>77xH♦G=z4 **n_xnh)))PrUh ̊:zY233}>_UUՊ+VkWWj8q\^^^UUUZZZEEENN}---<477WVV^xn]zu޼y}nOHH5^-\hPfJLLxbZZfڸq~h]jkk#""A/M&Sll^| ǎꪩ6mښ5kl6h$~H1X" k+&sgٴZmuu7޸y|paܸqv=ztaaVx衇ĺ}߾} ,ZD-f=vX@YY, S9v΁m@xٽ{#}O8Qaz}KK;wnsssuuwܱwaÆA 1i+j8 ]H BJ`ۘ-8NҴI.ɩݞ&m8icMfua'xcf@$hyLrsJ`פqp8W~o3sg E"kkký񼼼{o͜wH$ӍCCCk׮EywǕn/..KII2,H8N޶m[mmOZZڗ_~ =VD>wf苐 T* d0AAAT*[\_M|+[bp8x<_|… R.{W]sKӂKV4dϞ=B0==FwZ2plvUUUڵk=p566رcp]FS(l6[(߾}駟$  N'{Hhq1o޼)_x4y¸?77W]]-9rĄ:G 4J>}_>~X,~ꩧwx_.a"PI&ܹSPP_ҥK˗/߽{7"B62͵~auu[oG۷q\ %ڵk>>>###v:zƍ333|O(r0\;11zj4t;::R;3==#G, GzK.q8Bqܹ'xbʕP7󄘖(ڍ 0>^zX2;DC&6>#~%Ldt\.g<n+|Lvʕ1PHRI$Rxx8rR333ZFzkE+.^C wҸ(8M '>>ׯ_///h]]],+88|i.?LNN^~hrbzWhgp#t~t7hb+bؘF9pCܹsE8D. +.:fIRp(ߚ5k ^/..+**:wUTd2N# c&^( bt>{]v}>,Ћb0pET*ݾ}kLhd^^^AAAiii###nܼySR8q"55b x/+4>T*V*gϞMNNd7oLHH8|0]~=!8!x.+::GU(큁pΆ`+W޸qcrrl6߽{7<<_W]]ʕ+t !<gN<^ Ɔa|?VfsCC޽{/\&%%aD0?D#h4lȿ]]]sssaaat:=>>>,,lllNdddDRB^fA}0wHI4EPVZZZZR._k! oo^TZl6Nʕ+BFs8)))p? 5 tbXk֬pŽ;fgg>Wਨ(*,Bo=222::j6+L&Jm~~tz}}}dd Ot[{{D_m'x93̎?44gq/bkG@vɹ|#hEEEDDFH$111Ed@@񲲲֮]{;w lf???y3' @wr1g].IHH/** ߿n~&L&3))ܹs fUWWOLLD"___Lܝ#A7(.Vrss333B3<DDDD|'eee6;88٧  @bZ?W^MKK۰arI$cǎgϲ졡!B;ႍ%]|h4\.? ~߆].LSSS]詧 E֋/1( J54G~;\E*:33rkjjyH_/½a@]][(B·z`)%B errR"[bHDMQP xΆӳ{ D65p8JJJƞ|I [LCƹ9<j^p.{Wսj``}a333F 0B3=-B? s}?PNgWWE/Atz<@"Zz6 RJB(w߂\AMMM577D"BS&|f`0AQ %lŷEnk_{ZPO(*1fv}OA`n@D K V<M5 y`b EFC` ]4ڔzM6 0F$a$}[P*Y iz<B%鞔^pL̯ |+P`ov 0e3G; NiB?B o";#XxPfpеLH[o͵O###fƍ,QXXxر|ZmYYYZZZMMZn]{{F u떷wJJJccc?ܕ000PWW'rNW*$d2566666VUU={v˖-y~̙>t7,ˏ~#d!>~`ĎW9w;b 4pn.VJ兜!;22R^^c;w8޽{I$x'NWmll4111充ofFFFee}}}!⫆y׽B9N;Tx[ v0lڴI{f:><<\RR?~9rUUU9sY,~ݮ&B?td2?))ijj 0<<S._t'VpAippppppZZZGGSVV{1:WT_Zmvv பȖhᠻh/z./$Z`VswH$ʪAgddlڴp>5::t:[[[gffӷnjX"""nݚ]@rr-[;;;G:[wv柰x- UmlY%%%gΜyWSSSoܸ{T*-..NIIAXvv=333))G,wwwzF333C"G---FrMOOLx3"""##cvvvbb|]ظq[aBXVw5kքT*???| F#wFxowC# nl6oܸ155r\+VӟuVxܬN 嵶D"Fs84 Ld2X쮂*%rOPn)`_$j՝:ujǎdUUU~~~&I&mٲ%66D&}KsU,--]ltk֬xǏK$1xNѣG)_|! "&Zw 5oD4 OE :?BbѣGһrxF) ˝fvttSGXXdjkk;NNNr\(fffr9zT"=˂ۛu:@!s1G_!>.p8###&[( d&I AAApS lNc}pshZ###| fp\oooOd2R&eppp``@PD"eۜ.Y >7C^$(,11MD#,'ds3DR#}vuc!2h (0߃P=v ‹8!  6B7Z zmB @v?4KCr བ)N'SlL"H㙖P(Z1N'hqBb"Vh,h((x BLwP.A0Z{Mx%yL2L R0cff&::իJ-KKKKBB+^SS#/ގ˕B"m6J{ŵNOO'&&"SSSZ dܱl׮u77S=6o'} khhT644l:^WWt:ccc`JJJOOOOOOjj*Huu͛q&*K&Bp8n߾bVXA(<&zD-=BJ$dP^K\$WE0O^݁ XDOL0I NNN :p^|Š o߾슊Ǐ M@kk\ll,_zݿ/>bppfQԢ".jJKKsrr}]ј-++{e޽d2j5\KRihhhSSh\lGd2+|"22H**++ܹr'''\ܺuϟO^ZVVlwYzu}}zᇵZmgggHH\./--NLLlmmPTAAA333MMMQQQ˗/t]]]l0v`p:aaa:VNaÆ^GRϞ=j*oH$P(h4"N'$$TTTLOO x$lbGd28q"00BRfdd={6 ??߾}rO>d4MVs8ӧOL&8;UZZT* EAAMN<)J1ccc^z ik印KIhE8c4`1'w=X|`p@} q_8(7\VV&NVݷoɓ'ɗ/_H$W^y7|w?99rrss漼V+eXd\.՜˵}v\yڵΝ %t:c=`0wd2aꂇ;ζ6F(4`y=LFL8v믿nݺ;wd2YaaU3zuvٺukrr2ikk3&IȹBؽ{w\\ŋz=BǕӲ}ѡ`^ {fggߴׯܺunٶm[```oooww7NjpӧW\ &HcĎa^07q~0'<p5_z322'&&Zm]]J*&%%XH_rbܹ Юvի%%%~iZZZkkkTTT~~~yy\.H$p) 444;;fh4TzŎ۷LwT*.)JTT۷<}vvvj 6 3l۷o766^x133wޑ卍B'** qFZDppӧ+**`0DEE 7oō*⺺:@/YfM{{{ll7\p/HΟ??<> endobj 97 0 obj << /Type /Action >> endobj 98 0 obj << /Type /Annot /Subtype /Link /A 99 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 471.6457 147.7500 584.1457 ] >> endobj 99 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coverage1417.png) >> endobj 100 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 101 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 100 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16058>> stream xitǕ.x#kP EhQ$%,jyd%-R}l=Y2-b[dQ\YI" $ @a) @-#`dDdV̏?߽̈_č7c1Fa!BZ1']Xfӓm6vʺ_;66I&dinnn坝HԩSEEE===pcƍeeeUIDtGGܗ%"0==}…X,}뭷 xމngΜ9e˖P(sss:;;5M.,,BoqpptF"M*++#xhhn ]8[q8hS4%Y+B؝<(UU 9XI$ %mb+3Jt4p8`OOW\ XNabą"N5uttp-@h*`DS5 {yyyp(//zPt|`ܧz#[ÂH8Auuu\3(3E Bqvvxx .l6v~IMMXX1_q9D4 j4JD@3upMTU=uԩSh0we1&֘IUXPjGjX4&v1B.>R?ż_K}iCcf8 꺞JQEQ,8.J4;QW7 ( !zꚚz;k(W334i2KMC/ XӴ^xallw߽? KzBv'7e\)ɣӳnLVrjnn4i   6fzVFTqcgFvm۶׷tM@osVq#+]vO}Pm0W]uU2,))!MvA:N^"t -Z/5XjՓO>jl(n͠`rrO\m7;F]{ythy׆r۷\C[ &XvhiiI$eeeMRk5,\D<\ɲ٪S7#H_*FzEHCrۄh ,[l|||ddT+g.p~gkWqsi5,%(bGG ۬j2F' aK[$&`~trTE;Fx2>Z4g5Y}En19#@H!+yP xYf.\{]q{R#UY%`KJJF|4NX?F"p o:.F{90AR1JQF r(UYZ_QKAq+ŗ BАFd(#.nR<`&L) E Jbr}PQ)}ƪ`k;D"A~NɻhI1gv(Ak@VqƦLGLkD#i333@lO}ܹSʚsQjƈc#ԋ.J4wyOHfClbg,ZTUu\XEoo/@iah fK,f%Ú  š62Ẑ#LV1SSS.k||Tmٲ%HLLL? pB9ϳ1>sL(`0l2HZ94i JFЄ_13w`eq^HZ%% ONN644>+W`HR&$Db``cLI,oy]ZZ^+vnqTqLi %HzXʰPb΢Q1?_%$?0g\γK:y+@ @'X&ϛ(ͩXG{^~yu p`rsK|}b7>5<Z`4ǟ̠2$hX,VZZĴm6.cDY I8򞰸wF&`zz:씋`r@ JSLn- a|wqH0k1'.Z llakl7+ʽmr/]5[1"slvb 3(kƩ[*DE')d2Ft@ qYȬ23ZIr1ΤE3˖%T(4FPKEIJC{Ub+VT*SU\2..Ĕ7%%9Ĭu,[bS;9!?ƶo~=@MÌX)--D"lIb;iN "d)%HNϟ?O߿²UU*@ ې'SU 8HTUU 2бcHjzsaRfˇSm(6JFERʃK )BL m6!J{ttT %"g# Km G8 S /p:!LNNvww5552ßtd\F` )]]Q_WIx|vvݺ[Ki P P nfi @`;hqW}nI,QŠD''h !@@ݛxJ.ѰYBxp8?z ggCYP3d_t{~!9T54'ξ;wx6mڴk׮y()%cќ^D"5nJ09<<( 9 {<%xtR)Fv;yw9":>|D"t:V37$bIو@OOH*i!&ؒ@PP/N[[[;;;UU{2u]߷oO<1>>."`UUwyx?)9X,{Kd_Ig}}}7rJ9_J@$YXx [X8_AQ,B? x^vMnMRT(l?GgΜ)))!->E kꫯnڴOӟg&''_y啢Gyd``t]r{ݳg],E#811Dd% / "p1G]AC=$dMㅅ5k?~|xx8T*E~A)p8뛛[ZZ ׋bnZvnWDD>Bs֤rEQ:`5ўi+^iB, AZsY/j^zm۶u]:bL#Bq?p³P###6l,@+,tV|^,A98&)sNĉgϞY~ng}*ÂW,8Ĭ=Ry˃2# G҂R+nc$n;ݸq;޽{8Zb8dm>-iAםLK|Pd"˿@Ra51ƸnWWWK5r؆b\>!w:!XSS6YF% f7( yJڲ_M,:OX.^wH7&1~rb#E,aI+'/J4^څcaGjc"Lk2\/z`{衇y&qt…Gvбc*++O>]WWJ|Ɂh4:33H$8ۛCu\O?tuufD"6ybbbnn.++yxxbY)w_ƌ 髪={*++ip8<66f>`,l㳳9r$:333::z…x<~h4뺦in?77wrr7߬TU5$#G协;ݻwfeeayk1tb驩:uTee 4Mx<?puuuii)j"hoouo|q\p* F"XrUUUqVa|Ωe+9eRTwwiSSS999~2ܲePUU|<==]SS߿jժq?55USSwM7E"p8\ZZiǣhMM믿(׿Ǐ;vLӴݻ;;;KJJ un?]Id Pqq "HCCC (**c}`0r֮][RRzUUUvvv}}}aa333r plݺ5++~nnirrrʕ\jh=I ;:::00z\r0(277M~h\n盟NLL466VVV"VUUr˓d]]yW ht튢TVVVWW@ PPPPUUH$ zjhfvA^e"mO8JaBI[?!T<]r%tЦV-8fUB;ĄfϟNRLjd13%IEJpIKn=zN`q>ϿNoooo`Ť Ow?6l&Pf9uaMP~(glllbbBd2900x>6ǥ& _\/E@,#eFP i1SdM@qbQڒ[UՁ4M5  ]Ș}) #ccc6l~mbfE(ӴۼA0A2kQ`C.>ȋrY4ABOK"=ىak`ffoowؑ#EO$!AQ0qUUkVC+K՛1u`,Ai [*9Uٳᣣ*M͢~c1{pIFf֥O5~u֑\x?C~^q88 <lEG B`.94H 5AN;B].A)MiLx~_b1 t]F]]]! (͢%2ܿf*t/i/ %UJ7{l ~ץBV1x|͚5tĿavwz2q hHwk@4ic"%HNv8,4JA]uUÇbqq\ҼBQֳrhJc!7$Pi?xXi9000}/pF M/V8aԕ4vdaEi L.T@iyE%CV1ׯoiix34IDk) +P׵H*,%(BeB#<@Ҡe@wwȇ` }6K1!a/D}Aʱ3ߚ! /zv(__$}m6;-D?G\CcoNGlLbr]`2q"+K Ǧj={@OPmaz~ cc?.=o#HjkwtygDVB93Jصu-%BpǙı_VLu%bM/_`7yOU_Y-9ccE+z"'Ge0=P>1Xu\6b]qCT??œcnMGP\R2iIBʍ[[&&;P oK2413muj݇OȅhVȈQquDNNaʵ2͗c'r41,F}JX8%ɳYfJژ-G?C,N 8g8pe, $Dr gt75SqItBIj^,b,r/]w|JMtp<ݺd2IwAD(B^8HjgRR)]R*\a RRd*״*`]]Q.T}ޗ.TFPUUUMjBT]ׁTUU5 TՄ&KJ& zꩼ/| c؏B7F;:]Ԍc-(,=ADf]hl2xfp0Jpaa8p$Iә!AI=~x"(++ BNsƍܖF޶OAN J_!"ƷL%IEJ.U;%RHŏr3߿S?F" ߹%EӴ.$'|MΟ?O+"`ϟ? !pt"AKPj!!(UB VçFHAyzD>k;v>fEQ4McrAJwwf[ni]]]ؘz~>܀|{lllj'SSS:x kE[gzz%ȥT%(JPUUBX:DZm?MMMPhpp0J`&(Fɯ###---㘤{<&_|뭷4M?!= QPEE͛Òe O~1F8ܔ,..s$}666ҁ6#Ho9ߐM)(nٳeddꪪX,_;B^wEEE?!~_o߾f}}/--xW*++gc<66cLJJEEnpBnno|ryZq#5fx'_&>00PVV~Y<0&ԉ "~?!H1XL Hk֬!}E]zi,|% 6^Vib׻gϞ`0}vVt4M&xh4?w}7QjR4M B$iii႗E ǐ% , JBZC7*iB( \!{I.Y5FWFF*'ł 'JoZN*JN)tTLXv2/nfJ旛f4$PGbjAXOt:u]~g j1ַTU%f+r\.H]]MW^YfM*=xڵkcXggm6>>OG?&BlMϸD%\ \sU mߎ~CCC9999sg{-[t:O[Z[[VXAV0KjbbḪj##ʕ+N>=22n:]ק=Z__={>>}P$ɗ뜜###Hdrr窫B6::v~ӧ7o|Ǐoٲkϧ4)V0Dld2u_W`~~}˖-d!=y :3N8aٜN'۷o'N f%ifѾp8F<O$eee///'1SssKhM,6uWmtB( MLLZ|hh( "FFF3%%%HDUղ7|8''GQ[ZZh2 PFQӹu֏>pDђEQE!u\رc.5pQaqNj"b Lp66ڌ4⎛H$.Ù̆=4V堹 ՚R*aK<g?,M+-,Hh>ryT jxD:zI? ,/e{k=#4M{ZZZ0ƿ/o`0zNNÇO8zvÇ7o\ZZz5׼K7o4maarE"ktŕW2z˗NNNE"۝_TTtС꾾믿>%%%}}}?wܙL&WZEvn],S]݉(p(Ά1ƣP윟'3YYY$q:Nɓ@ܹs v= ' FGG{zzzzzVZҲcǎ˗s΋1YFEyyy@ //|}7:0===555===22rlaaann߽{wyy|IIٺuY^{ݻ7lzsrr䲊HJK5;3WDҮ1}ww|HooڵkUUE|>=66FX$iϓ ;;;??Dcǎ555%Ǐn_~}(ztf;vEcvv7D"D"uuueeeNzHNOOa(,,,--=qD0l~?>}:l޼y||c͚5Ν&e J3Jw%)w B!Nx ®i%*m.CVf!F5jF|hF|1ZA,NjW{b(fffu$RUȑ#rMMM999T1k}ʫܹs-;X,WXXxСϟojj*((.--q:.+o޼{hhtb'&&V^H$8r|q8pح0'εYR*+G4EyXXXxwD(z'EyGFF{/EEEo7޸066nݺ˗K.ڵd۶mh?lllp\%%%---c|G-//?}ᨪrjf F xު*˵f͚]vegg? pn 充PhϞ=OɉD"[lYkk={l<]l|nnnkk+9 )pEE3DOR7JRdK(++kv{EEƍ3Q~nn]gffn& %KQ! +++KJJ8m۶h4JnsvZLJاH˵׶WB 7 Unᆱ믿>ɪ*rw󕔔dee]uUnԩSvyB)??ݺuzkGGʕ+UU BW^yeqq(++u}ڵtD$l H#!fenkD~WLą:&dHRl#q"CDjO[CwHl-JPV B: l>V,ȖzQtT02PW48qJU Ξ=iڱcn6]ׯj777Gy񪪪{QrW`PQ˗l6M֢n_XX K̙3`phF~^H&MMM.d8Lfo6뗱h*$(C رX,va =6mժUҾСC_yZy导|wϿb؉'*++TU>qv8w=ٳgO>]TTtɼg6669rdtto|wW^^[T++ۢI:% b endstream endobj 102 0 obj << /Type /XObject /Subtype /Image /Width 22 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 22 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 226>> stream c`0b@|XMb> YsE&qEX\"s.HʝX"<猞Jц TQ{zx@x*q\P;d!'b ps:@eÆ(@r) uS@ ]}CCXx MԹ6< 10AY@@lŴ&X \ jAfXv@CXiJLU([.C endstream endobj 103 0 obj << /Type /XObject /Subtype /Image /Width 22 /Height 18 /SMask 102 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 22 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 18>> stream 8c`` endstream endobj 104 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 391>> stream 8c`0b p@(mftt,[BH d>(k> Ys) 'S0lQJgbhCTƹ6w!~$,`sI H_s3z**E*P-@ 6m NPLTUHy@bR$-cٯqHq"f]0VA\=t@ǎaC!l)++;ה>(!m9%$SŒ)`@(4,@sIcB׀T@I?KO?&s3lxvbaBZ609ZK0```/SX) D?GV$1!_Ҕ"\ =" endstream endobj 105 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /SMask 104 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om_x \ endstream endobj 106 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 383>> stream 8c`0b ul;7c B*fXm%1 `;$k՝5e{)80<.4ܦAx@T߅ oWlK s@R6bAW1猞Jц TA  ~I0SUsSĤ H`ѿ 8${8x|Vt.̹`,{&Gҏd0֜3@r) ufLdDa?`cB׀T@I?KO(@3DaCL CB?вYu$I "Y _p+eapraS#pV VDI ltׯ4%|@C( # endstream endobj 107 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /SMask 106 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om_x \ endstream endobj 108 0 obj << /Type /Annot /Subtype /Link /A 109 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 -7.8705 260.2500 134.6295 ] >> endobj 109 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/impact14.png) >> endobj 110 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 190 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 300 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 409>> stream xA 0 =fy9뀟\| endstream endobj 111 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 190 /SMask 110 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 300 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 32791>> stream x}yxUӝHA@qXePGeܝguFNjuzAP1"!@ }O'w:uͽ{|{oNw5' L /1d:&8Wzsg1@IVY_P|E8>b"iؤJqJLA<H)b؍'_2A'N̛7oo֒%K>9mڴ5kִO:urPbFzqr^.&\~ (ܨ:[^^~ي w\ǎcXd1jPJ_wuק~*YvmvvE{; ,C!U_J _@wԨQ>`}}h|z>xĉ7xc֭>… fd2\ gpz (J/UUU;yyyO<đ#GZZZ~uo)((8|~~>|Gj)n %>|ʕ+9w^qd ^ti\\\ ߿cc#.v \6aaafg}ht:]\\y~{g <ϧO6M <RcXwԨQsmkkX,sn7;::}իW^:"""???LJJ?>''Gn$rB8ظy_8{섄b7t_ױc:AN:uִ4/~ /+.Y@iQ!kiiinn.**-[._\RR2j(F3cƌ.,:} /`0x]J`"8 y)qx} JnIAxw:ތ3on2~;y$/ph4|Er0U_J+t:jjj\./_\tI'N(--Epl6ٳ\(D:;;/_z].WdddZZZmmmEEEFFFZZZMMMTTTkkkvvvEEon:b>39~N(|% }>X,b#8;w堐!YBT޶m۬Y.]T\\\__?x`JJ⮿!]@ +:riZ Ivp&BH Odt/[`0 P߽pAHұXRagڻwocccZZZ=*MġDș@ +E7|3++sa($#+@VPFҥKuuuP'9+' Rr8֭3=2W0.xT#a5SNw}wuן'v?#{98](d 2 x={vDDF( !2] 4j"/*LOO`"KJU$Pҙkמ>}dٞyp(V]]]+V'j4sr-P?7XTThnfvVZq4 6" J$Z #7,aS4|q#֔ꦛnz*ŋb P.fba v@ x *_L\Xs L . tQ c% *i8|g+abg\PQ +8U|XXXQD<0DKJ"F>QB!cMs:%Y (ZBQs=2TkPv `R,g\ vBN93 (B0Pbg@AuJKK?lܸ񔕕?nڴ'Nr>D(pC &SUY"]*..~n*¹s^z5k={_GGVh4Fjjjl,PA("S窠pX|3rDEE^<"qB[nǰbUP8+"EBQX)j 2|v=))iԨQk׮u8Ν;WXa6 ;wɓ'ڵKz&OAAh,--UK,Р4&U"… ǿ+V'lhhxꩧ =}?3XPPq\dd$<1$XXKP8+ؽyAz{{o GGG;N+-#HъRUatA֯_/={lh4O?tgggTT`ǙL& .#n9 } g]NNG}$M\p?񏽽 VS%r5^< +RV^D/o?~ڵ^zi޽ۼyo]TTsN "+R(J-+-Vg Qn8oJ`C!A.œh4cĽ+S&L0Lz7M^^>\c2я|k~y˥^__駟\.2qD+=5""~Ea.]B"A޴4шxRN5\p=Pe "+\Bbg(8}<#TWW?Syyy wqGDDDAA{N7 ^cA$nR1B /`'xҥK>hJJJRRRkkcccz-vq[ 9GQXE(9VG[nG(|"ʈ]A#EU%(Uzuk#F1B)K#;v,`N021OQZ(ăH")^_JpK'`yhdHPDV L 2DVZEPU'VrZBR$yU$;+UQF)J BB ok b\T1(FVEAϞ={3g@!@r.bwΊET TTT+WTWWy[[t_'N1};"A-qɽEJn*YQ@^p8JHٯ9Dp9r)FQBRŊ]v/O6)qI%qHTp(X#xQT|qD>q"#+l III&MڻwovvQ`̶wygҤIW\Ϝ:uj֬Yf/ 'L`7mڔ"x`vXi9KII9|IbccM&rEO v(E#]B|H Oh ɝY,O W^mhh!))vo~SVV/`ǟ;wNWMMMC+y7 ALuo-!@bcbb|>_sssLL R1"i@hD1I]X唲@f rDQ;B@V82111wqGdddootIN MMM}'bbb6l믭V )Gľ`P(PXi{ZOC #Zc({CIF㸾@ p8\.WRRv*NXtwQN"˱+R8s߾}}}}UUUFݍ6'22r*=7!!o/+= BKPjYiAyjư0d@9cdeb)@wejΝt_q08>"g(9dŋ?5y䔔򜜜BćFDD̚58#DI/H帱-\"PXi#Glhh0iiiVU lw&E6U@ ZUp(x_._6xf]DQD\<@ 5EZ( &iȐ!7nlnnÇU̝;o_{1 ~F{L@ Kb 2B-+EVTA)p䐡 8.)))###66ʕ+< ؞@BA!yŠ.Բ4nlp & iHRM @t1S7KG,((=&aUr qF(((nݻ'صk^(kYiÀt(}* gԨQuuuwzn$td/(iIQ ].ׁϟ?/\^VV8%k$s`BL3.E ;{Zv4/7Z(HFXiϝ;|\\ZeAgIbkdBt<1uԸcǎWy9="+9  wh馛f+~kL9&%JQ;ZVѣG{^'>_&':ZfBNj4qСC&&&.YDʍGDK5z@ 7"PX oBv;#TxuRz\w'xG|뭷,Yٳn͕߮;vXىw@!VĨ{N2|[{oVcc%Klܸn]bDHͨ gN8q¿o;vSlPq/qV@h ԩSW^-))L8WӳiӦÇ+Vox< 6tww_v E€RCKiPH/^gUUU&M<رcԩǏ/**,_|흝mmm;vtr ;U>?/W1BYL@ `6z=n`(nh y(JgBeM6L@<`KjpVeee-\033SjZ#B!TŞ4Q  NJEB`8.77?zn:t$oyz{o ̙xb@CCÍF#$ wT|.A[M:o޼$X 'Oo.\iӦO6-..gx O*m%L$S g@PDVZlڵQQQÆ ElAb&‡8R}QRJ 1bĨQ:::ƏoX[;+Vt: Զ YpV TUUlFi q)i+ YiGꫯqqqw_jj*L1)&!Pmءpb˖-ɐ6Er'n@I l?l6[yyyYYYBBBXX>E,P!YkQ vʔ)+V())X,F(bnĀg}"P-ܙ 6YnmZޥK"^Sl3 x3P+*CJ d|:lKLL'B!a>(FiARŊ?{쉍=sLzz- 8r7v/@!٥*aP! L9rdB!YG8,$4(Pa(D <3R@!XQY 0|e˖;V|77x+pVZءB`ŃF"[:m۶ 6X˥o6W_U-? 8\ `>l͛7Ǐ'BQOTղh  a%;jԨW.DA4zהHEw;FP!4x\qqO8q1cƬ[j'O|ŋN.M ,R"ք˗/2dȑ`"`D#|^1U7]*(Uu O~c :hРI&޽;L>>ɉ:tHUB$HdMUPS6TH=pW۷'ǁ8 ^ȬX Ȫe׮]ʼn6-'''**w4֨$P0ڪ@\,Buu3gfsOOObbb !&&d2%$$H Ciii=!5rR$()r$666644\|>%E|ʔ)_z}ff&@3ļ 0{F("#F=q1c Y&n {@U(@dz$R333_|Ԍ3fʕO=zh\bdڲe4>99`07 /^9cjp 0y#GN>}߾}Z^^^LL̂ :;;/ϝ;Ww^{F,,MHUPxK|Sg"#####G!Yv͞=;4brΊE*("Cw})rB ԨW nHq#5'!읂Z(rvmd*!)BnB%PFPxAl#Ģh4CXN(@µJDDDرcqd dMSdEӡ@J )Ry`% 2#\˱|>U &Op(wTBQX/_nY|UFaY&kZU"n,j,;+\}۟O {ܹ3(P" xG"HTy(ڪ|Bx^?糳;^Nљ3Æ#t=eJԺṳ@ṆBN/ $17PDGaeRdEd;k4_IrP+)Jvr M+| D?;=l-*ρX(^DyHCeEBRmJOfbg̣`4rO(e%,;'|C4#c%i0BBYL.Aɑ JNr*`7> vVJ=t) TX C# +]1-MRHB4PD)X( BTIJ(V yˠt֊?%Ixxxtt4Dj[iH92X|RlP]mfJdo֑H uP ~_UQ|{ FӏoR\\\hސ:  sRoh*=ؐX+R!(D+?R$V/~S) de̼a떒p؍(ΐX,(*VDq pIɉGpVH}hH΄Y! .t"Xm@ۦx<1AYmmѣG'7Y D|K^`ؖK 87\o&+|_·؜BAdAhr@,D;6mBtt4 E9=p(|۫k:v>b"&QZ7`?UN+|о=; zwm CʏHbU BXz{wH|ܤeJrȏ>i/tΛu;V X)'p i?uxGOxϪ ](*8hr A#W~/%/܇i PWd MjԑCA0;SXĶ*dVJ N5 xuY<ҥK7l9裏-ZTUUOR.,](B)R!p^ HEa.jL&p8nbq1c6m4hР0qFU 35 $V@ޟT_@X3ɼBwBb555}}} MMM]]]aaaiii TVVHRUJ IL [@YЎ*&C][[kkk{{{-˹sƍes?u <`4,J^HZo2vϷ{<k6GQWW'>[[nOv8%22R|P +2HI{EL̠b&۱cGkkkMM͛oj*AV/{N[lg}VPP )Pm5G6.$8}Ae\n۶r|lNOO_hѶm۲de;W|?hSޒ7*Š-TRBY1cTUUϝ;cРA'O3gd\z XcrŶ+8l6/[硇5L=իRSSlْaAΟ?o0ZZZCE(cX0镈1Eȏ{<$?׮]ϓ'OFFF>_nomm]re~~ܹsIX`CN.u#Y1$,`Aj |EόVw\AxM7M:bpwwssrrTWi=2A 46S8W<%8>Z9 骪\.|T`éEOH'K&ej&KӉ^u:^j>o׮]@`ĉ\cL,F ΊbB"y[W."PUxx}Q%5Ҁ/r?"5^ s;@WПӂk8p\/>>{qqqf…ӦMFf&LHLL.?iIV^%?$}3|؎{MMM7ov:e̘1.`8q &H~RѤ >x[^YzL$"+%-Ed +D ZvܹseΊӧ'%%= %%%1أZ7-g(Baxsrt:mݦh_fggƾtR"< ttVLL @w*M;|AP@ʿ1#""+2:>9I D|~`sg̘!3fLnn|qL^^f9h(@.$TR,LddY'OA)*%x%.J]ª_yz4pw,r/* o eTt2nAxׁ;n[ۀZpإbAPN nBAZIIFVL" :I4DĜtfšZio)JѐBRpoͦ dD T@–*™"$D p_$vTzE2z=B@x8i Ab3-jVž+ਓk*$ sbC ryZ  ҿ C3x+y!,pЯ2)ҭ@W2I ٚ\пTR:Ú85"3ch:qZVD f(8,=Hq&<)OI̱ؠbx\oafa_=c`SҒg Wdz 8ठBH3DT$!n9O1JI)/ҺKǰ`e1(@bJI9埧K^B$gmNgBM BLpVue͠ "V;(SB>)lBjŠ>\j ǯ2 C P~*15YL%ne",@8euUKV  /L RHKLg;q 8"äe&]/пM6QeN Pj @p(A6ĕ#]PXQ"(V@.‘=f /[FR]?G;9aa(.F7Xe:IY sD5q@Vx#bJU8WDRlnc6x 2^X)Ev`Ejle%Px(uO HJLR CIOlI\F,I7&@WFOfIyM: X))^DivdZywY2e )œFD@"9|Yq4ŕ1k#j!i;^EL_Q$ J/I1̓2w $(Fs_q) R F JNH 33m|;1b"쬈LsJ D|=!>Z자6JtW D`{͕28x(bxy<D(y$t=x 7=ˇ@X$9UԝK}9- D|5\#2iqd#5^/$r2$8rGwqY))"@+$~>8d.VHIS,d# NJ¾B; Uڈ {ݴi.\z3fIcbEP;*P,XDN;ym۶={v޽^ߤ0cEU$#$pV 5… O=>~sΝ:@^N}t ͮCU5%<].IQ[N~[=/۱mwl6V;e Dpv?}􈈈]v9}8qٳC\.Wuu袎x@t @EûAmϮ] RYY|z 8 t*P/5]ܾu%[I,zIp+@ 2&)..{ĉ_}մiħDǏ狈>|c,M7%###&&jE͞={̙$TaF.],dX{wjWUtرc䈨(N'Z4i$+sG~X,#>0??j&%%&<<74͡ߪd͡D 66O\!NIMM]bq#ocNg2:;;O:zԔ>}zAAXfwWZ4x+Ë>iӦ 6h4WXX8H\P@A | ?~?_̜93%%巿8{ 7ܠbccYpY Pħ|gGtf{Zd2%)XT%lV^"} |/N(j"ρ@rZ(@ Pnvꟁdi4(} 89YY+]X,DDd'-[SSсa+0ԩS}ݮ.i(!@!sa1x<!CK.stmngÃȶn6^|?u+i"/$xIN`rZQQSON,G ill|SSSV#GbbdH$qEI {}_{ʐ.\_3=zW~) x>^zi[!@}wȑ#[ZZ=syHrϹc Udd{{ʕ+͛WPPk׮#GZVIAVZrGMMݻ'N(>T7(BCtREEŴiÊ܁{iSɓ򦦦,Q˗/:t?SHP>FpΆ_JPDQ~]~ٳSSSGGG!M/%rAjjjZ[[_{5}>CSm82ܸqcFFƸq -5]P?Cjj={dee@ s˖-HII;doozV믿^YYyaDJd"0۽k׮HwUVV;vl6'&&5%Kz###̙h6oޜXRRx?x+kD(ݳgСC^W_}]TTt8iPSN[~ٳw޽xkʹ ;gQvt8iii_~II\*SQQYPPrNgoon7 yyyo`S.oY[[po6''/PL;b588#Twww]]]\\ѣkkk/^|ssT3fzzzbcc͛V5..#@=999''l6WVVjZm4322Բɩ5jСC<7$''[֟ ^DNruVn$Bw}wߝ3gfn6{zzlْ)_tԨÇYfٱGꊎX,_Y46\l3B?O;w5kVllȑ#ZVVp‹/fdd>}zĈdXXY,zu͙3tvvv;wnر C!⻊h;J!@ P\\/VVVN:5..nԨQGX,3gμxȑ# 222.*::z?lٲlٲcǎiڳgt:vTAuG;t)S`[Яjّ>(33fi493 sYt)󍍍UUU-7nh4{{{^ Lp'ct(@GGΝ;_xᅬ!CL8`0!!bɒ%O߻wƝь"##,Xp]w?b͘1 bZ5 I~C<q#?FHs+++;6vzh0jkk#Fx7<qرGzGGGqqE* m;QfsQQS}ܹrAءp' Iat(_RR"fW&$$N j̙8}4qVW^YvmOOυ ](2 G7o>|ԩS7lzO8Р@d ٬P.->>St:ݯ|^1g}СC555p^rҥKFݻ{{{;&@' xvT8b)((4iҕ+Wccc7ohР˟>}:qzb)~ E磣'L}FfsxxxWW?,g>}tuuu~~#P,322~_y商^z5??_#ܾB2!CNjJKKOcǎ(sjZ{zz7cƌȘ3g|aÆ1h4#F̼z3g^}Ճl3gΈq10x  9FFqw/]$7:.33sر'Nܽ{ >sA Yy￟?>hܸqyEEŤIx]DFQ<ۛ[XXwĉ^Fc4Fѣ>~[>裑VD=/:+~Ç.]j*>gΜ>hԩ˗/`7PRΑyd2i4n1cݻw{ޞɤVkAAAVVVzz{1ݾ},Aeaj;;;OfYGyo"kfIn$E'c{HV2hР{W۷ ּ;v|Dp;өju: }F ۼysvvȑ# "" HJw!kHqJWW׆ Ǝe˖NObp8zF|ӟf͚u̙iӦEEE3&99YO 9P ^zt^ܜ;|߶n:yUV-X`ǎw|1 G3ooo_b<駟9:`YP S HA$q'jZV0f̘n󵴴?~U`0̛7/77ˏ?xCCCFF裏 HF6mڔ)S~ᨨk677]xA WQoPM~~ԩSt̙)BEEEy~j~W^MKK{g/_xY8뮨~yʕ.TLD(3^FJF^djEEEv]z.q뮻Ξ=;s̼nZh4&IjjjFۿUWW777竬=@/L_3f5j|gX|Iu:nΜ9s뭷?>77xH♦G=z4 **n_xnh)))PrUh ̊:zY233}>_UUՊ+VkWWj8q\^^^UUUZZZEEENN}---<477WVV^xn]zu޼y}nOHH5^-\hPfJLLxbZZfڸq~h]jkk#""A/M&Sll^| ǎꪩ6mښ5kl6h$~H1X" k+&sgٴZmuu7޸y|paܸqv=ztaaVx衇ĺ}߾} ,ZD-f=vX@YY, S9v΁m@xٽ{#}O8Qaz}KK;wnsssuuwܱwaÆA 1i+j8 ]H BJ`ۘ-8NҴI.ɩݞ&m8icMfua'xcf@$hyLrsJ`פqp8W~o3sg E"kkký񼼼{o͜wH$ӍCCCk׮EywǕn/..KII2,H8N޶m[mmOZZڗ_~ =VD>wf苐 T* d0AAAT*[\_M|+[bp8x<_|… R.{W]sKӂKV4dϞ=B0==FwZ2plvUUUڵk=p566رcp]FS(l6[(߾}駟$  N'{Hhq1o޼)_x4y¸?77W]]-9rĄ:G 4J>}_>~X,~ꩧwx_.a"PI&ܹSPP_ҥK˗/߽{7"B62͵~auu[oG۷q\ %ڵk>>>###v:zƍ333|O(r0\;11zj4t;::R;3==#G, GzK.q8Bqܹ'xbʕP7󄘖(ڍ 0>^zX2;DC&6>#~%Ldt\.g<n+|Lvʕ1PHRI$Rxx8rR333ZFzkE+.^C wҸ(8M '>>ׯ_///h]]],+88|i.?LNN^~hrbzWhgp#t~t7hb+bؘF9pCܹsE8D. +.:fIRp(ߚ5k ^/..+**:wUTd2N# c&^( bt>{]v}>,Ћb0pET*ݾ}kLhd^^^AAAiii###nܼySR8q"55b x/+4>T*V*gϞMNNd7oLHH8|0]~=!8!x.+::GU(큁pΆ`+W޸qcrrl6߽{7<<_W]]ʕ+t !<gN<^ Ɔa|?VfsCC޽{/\&%%aD0?D#h4lȿ]]]sssaaat:=>>>,,lllNdddDRB^fA}0wHI4EPVZZZZR._k! oo^TZl6Nʕ+BFs8)))p? 5 tbXk֬pŽ;fgg>Wਨ(*,Bo=222::j6+L&Jm~~tz}}}dd Ot[{{D_m'x93̎?44gq/bkG@vɹ|#hEEEDDFH$111Ed@@񲲲֮]{;w lf???y3' @wr1g].IHH/** ߿n~&L&3))ܹs fUWWOLLD"___Lܝ#A7(.Vrss333B3<DDDD|'eee6;88٧  @bZ?W^MKK۰arI$cǎgϲ졡!B;ႍ%]|h4\.? ~߆].LSSS]詧 E֋/1( J54G~;\E*:33rkjjyH_/½a@]][(B·z`)%B errR"[bHDMQP xΆӳ{ D65p8JJJƞ|I [LCƹ9<j^p.{Wսj``}a333F 0B3=-B? s}?PNgWWE/Atz<@"Zz6 RJB(w߂\AMMM577D"BS&|f`0AQ %lŷEnk_{ZPO(*1fv}OA`n@D K V<M5 y`b EFC` ]4ڔzM6 0F$a$}[P*Y iz<B%鞔^pL̯ |+P`ov 0e3G; NiB?B o";#XxPfpеLH[o͵O###fƍ,QXXxر|ZmYYYZZZMMZn]{{F u떷wJJJccc?ܕ000PWW'rNW*$d2566666VUU={v˖-y~̙>t7,ˏ~#d!>~`ĎW9w;b 4pn.VJ兜!;22R^^c;w8޽{I$x'NWmll4111充ofFFFee}}}!⫆y׽B9N;Tx[ v0lڴI{f:><<\RR?~9rUUU9sY,~ݮ&B?td2?))ijj 0<<S._t'VpAippppppZZZGGSVV{1:WT_Zmvv பȖhᠻh/z./$Z`VswH$ʪAgddlڴp>5::t:[[[gffӷnjX"""nݚ]@rr-[;;;G:[wv柰x- UmlY%%%gΜyWSSSoܸ{T*-..NIIAXvv=333))G,wwwzF333C"G---FrMOOLx3"""##cvvvbb|]ظq[aBXVw5kքT*???| F#wFxowC# nl6oܸ155r\+VӟuVxܬN 嵶D"Fs84 Ld2X쮂*%rOPn)`_$j՝:ujǎdUUU~~~&I&mٲ%66D&}KsU,--]ltk֬xǏK$1xNѣG)_|! "&Zw 5oD4 OE :?BbѣGһrxF) ˝fvttSGXXdjkk;NNNr\(fffr9zT"=˂ۛu:@!s1G_!>.p8###&[( d&I AAApS lNc}pshZ###| fp\oooOd2R&eppp``@PD"eۜ.Y >7C^$(,11MD#,'ds3DR#}vuc!2h (0߃P=v ‹8!  6B7Z zmB @v?4KCr བ)N'SlL"H㙖P(Z1N'hqBb"Vh,h((x BLwP.A0Z{Mx%yL2L R0cff&::իJ-KKKKBB+^SS#/ގ˕B"m6J{ŵNOO'&&"SSSZ dܱl׮u77S=6o'} khhT644l:^WWt:ccc`JJJOOOOOOjj*Huu͛q&*K&Bp8n߾bVXA(<&zD-=BJ$dP^K\$WE0O^݁ XDOL0I NNN :p^|Š o߾슊Ǐ M@kk\ll,_zݿ/>bppfQԢ".jJKKsrr}]ј-++{e޽d2j5\KRihhhSSh\lGd2+|"22H**++ܹr'''\ܺuϟO^ZVVlwYzu}}zᇵZmgggHH\./--NLLlmmPTAAA333MMMQQQ˗/t]]]l0v`p:aaa:VNaÆ^GRϞ=j*oH$P(h4"N'$$TTTLOO x$lbGd28q"00BRfdd={6 ??߾}rO>d4MVs8ӧOL&8;UZZT* EAAMN<)J1ccc^z ik印KIhE8c4`1'w=X|`p@} q_8(7\VV&NVݷoɓ'ɗ/_H$W^y7|w?99rrss漼V+eXd\.՜˵}v\yڵΝ %t:c=`0wd2aꂇ;ζ6F(4`y=LFL8v믿nݺ;wd2YaaU3zuvٺukrr2ikk3&IȹBؽ{w\\ŋz=BǕӲ}ѡ`^ {fggߴׯܺunٶm[```oooww7NjpӧW\ &HcĎa^07q~0'<p5_z322'&&Zm]]J*&%%XH_rbܹ Юvի%%%~iZZZkkkTTT~~~yy\.H$p) 444;;fh4TzŎ۷LwT*.)JTT۷<}vvvj 6 3l۷o766^x133wޑ卍B'** qFZDppӧ+**`0DEE 7oō*⺺:@/YfM{{{ll7\p/HΟ??<> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 113 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 112 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16058>> stream xitǕ.x#kP EhQ$%,jyd%-R}l=Y2-b[dQ\YI" $ @a) @-#`dDdV̏?߽̈_č7c1Fa!BZ1']Xfӓm6vʺ_;66I&dinnn坝HԩSEEE===pcƍeeeUIDtGGܗ%"0==}…X,}뭷 xމngΜ9e˖P(sss:;;5M.,,BoqpptF"M*++#xhhn ]8[q8hS4%Y+B؝<(UU 9XI$ %mb+3Jt4p8`OOW\ XNabą"N5uttp-@h*`DS5 {yyyp(//zPt|`ܧz#[ÂH8Auuu\3(3E Bqvvxx .l6v~IMMXX1_q9D4 j4JD@3upMTU=uԩSh0we1&֘IUXPjGjX4&v1B.>R?ż_K}iCcf8 꺞JQEQ,8.J4;QW7 ( !zꚚz;k(W334i2KMC/ XӴ^xallw߽? KzBv'7e\)ɣӳnLVrjnn4i   6fzVFTqcgFvm۶׷tM@osVq#+]vO}Pm0W]uU2,))!MvA:N^"t -Z/5XjՓO>jl(n͠`rrO\m7;F]{ythy׆r۷\C[ &XvhiiI$eeeMRk5,\D<\ɲ٪S7#H_*FzEHCrۄh ,[l|||ddT+g.p~gkWqsi5,%(bGG ۬j2F' aK[$&`~trTE;Fx2>Z4g5Y}En19#@H!+yP xYf.\{]q{R#UY%`KJJF|4NX?F"p o:.F{90AR1JQF r(UYZ_QKAq+ŗ BАFd(#.nR<`&L) E Jbr}PQ)}ƪ`k;D"A~NɻhI1gv(Ak@VqƦLGLkD#i333@lO}ܹSʚsQjƈc#ԋ.J4wyOHfClbg,ZTUu\XEoo/@iah fK,f%Ú  š62Ẑ#LV1SSS.k||Tmٲ%HLLL? pB9ϳ1>sL(`0l2HZ94i JFЄ_13w`eq^HZ%% ONN644>+W`HR&$Db``cLI,oy]ZZ^+vnqTqLi %HzXʰPb΢Q1?_%$?0g\γK:y+@ @'X&ϛ(ͩXG{^~yu p`rsK|}b7>5<Z`4ǟ̠2$hX,VZZĴm6.cDY I8򞰸wF&`zz:씋`r@ JSLn- a|wqH0k1'.Z llakl7+ʽmr/]5[1"slvb 3(kƩ[*DE')d2Ft@ qYȬ23ZIr1ΤE3˖%T(4FPKEIJC{Ub+VT*SU\2..Ĕ7%%9Ĭu,[bS;9!?ƶo~=@MÌX)--D"lIb;iN "d)%HNϟ?O߿²UU*@ ې'SU 8HTUU 2бcHjzsaRfˇSm(6JFERʃK )BL m6!J{ttT %"g# Km G8 S /p:!LNNvww5552ßtd\F` )]]Q_WIx|vvݺ[Ki P P nfi @`;hqW}nI,QŠD''h !@@ݛxJ.ѰYBxp8?z ggCYP3d_t{~!9T54'ξ;wx6mڴk׮y()%cќ^D"5nJ09<<( 9 {<%xtR)Fv;yw9":>|D"t:V37$bIو@OOH*i!&ؒ@PP/N[[[;;;UU{2u]߷oO<1>>."`UUwyx?)9X,{Kd_Ig}}}7rJ9_J@$YXx [X8_AQ,B? x^vMnMRT(l?GgΜ)))!->E kꫯnڴOӟg&''_y啢Gyd``t]r{ݳg],E#811Dd% / "p1G]AC=$dMㅅ5k?~|xx8T*E~A)p8뛛[ZZ ׋bnZvnWDD>Bs֤rEQ:`5ўi+^iB, AZsY/j^zm۶u]:bL#Bq?p³P###6l,@+,tV|^,A98&)sNĉgϞY~ng}*ÂW,8Ĭ=Ry˃2# G҂R+nc$n;ݸq;޽{8Zb8dm>-iAםLK|Pd"˿@Ra51ƸnWWWK5r؆b\>!w:!XSS6YF% f7( yJڲ_M,:OX.^wH7&1~rb#E,aI+'/J4^څcaGjc"Lk2\/z`{衇y&qt…Gvбc*++O>]WWJ|Ɂh4:33H$8ۛCu\O?tuufD"6ybbbnn.++yxxbY)w_ƌ 髪={*++ip8<66f>`,l㳳9r$:333::z…x<~h4뺦in?77wrr7߬TU5$#G协;ݻwfeeayk1tb驩:uTee 4Mx<?puuuii)j"hoouo|q\p* F"XrUUUqVa|Ωe+9eRTwwiSSS999~2ܲePUU|<==]SS߿jժq?55USSwM7E"p8\ZZiǣhMM믿(׿Ǐ;vLӴݻ;;;KJJ un?]Id Pqq "HCCC (**c}`0r֮][RRzUUUvvv}}}aa333r plݺ5++~nnirrrʕ\jh=I ;:::00z\r0(277M~h\n盟NLL466VVV"VUUr˓d]]yW ht튢TVVVWW@ PPPPUUH$ zjhfvA^e"mO8JaBI[?!T<]r%tЦV-8fUB;ĄfϟNRLjd13%IEJpIKn=zN`q>ϿNoooo`Ť Ow?6l&Pf9uaMP~(glllbbBd2900x>6ǥ& _\/E@,#eFP i1SdM@qbQڒ[UՁ4M5  ]Ș}) #ccc6l~mbfE(ӴۼA0A2kQ`C.>ȋrY4ABOK"=ىak`ffoowؑ#EO$!AQ0qUUkVC+K՛1u`,Ai [*9Uٳᣣ*M͢~c1{pIFf֥O5~u֑\x?C~^q88 <lEG B`.94H 5AN;B].A)MiLx~_b1 t]F]]]! (͢%2ܿf*t/i/ %UJ7{l ~ץBV1x|͚5tĿavwz2q hHwk@4ic"%HNv8,4JA]uUÇbqq\ҼBQֳrhJc!7$Pi?xXi9000}/pF M/V8aԕ4vdaEi L.T@iyE%CV1ׯoiix34IDk) +P׵H*,%(BeB#<@Ҡe@wwȇ` }6K1!a/D}Aʱ3ߚ! /zv(__$}m6;-D?G\CcoNGlLbr]`2q"+K Ǧj={@OPmaz~ cc?.=o#HjkwtygDVB93Jصu-%BpǙı_VLu%bM/_`7yOU_Y-9ccE+z"'Ge0=P>1Xu\6b]qCT??œcnMGP\R2iIBʍ[[&&;P oK2413muj݇OȅhVȈQquDNNaʵ2͗c'r41,F}JX8%ɳYfJژ-G?C,N 8g8pe, $Dr gt75SqItBIj^,b,r/]w|JMtp<ݺd2IwAD(B^8HjgRR)]R*\a RRd*״*`]]Q.T}ޗ.TFPUUUMjBT]ׁTUU5 TՄ&KJ& zꩼ/| c؏B7F;:]Ԍc-(,=ADf]hl2xfp0Jpaa8p$Iә!AI=~x"(++ BNsƍܖF޶OAN J_!"ƷL%IEJ.U;%RHŏr3߿S?F" ߹%EӴ.$'|MΟ?O+"`ϟ? !pt"AKPj!!(UB VçFHAyzD>k;v>fEQ4McrAJwwf[ni]]]ؘz~>܀|{lllj'SSS:x kE[gzz%ȥT%(JPUUBX:DZm?MMMPhpp0J`&(Fɯ###---㘤{<&_|뭷4M?!= QPEE͛Òe O~1F8ܔ,..s$}666ҁ6#Ho9ߐM)(nٳeddꪪX,_;B^wEEE?!~_o߾f}}/--xW*++gc<66cLJJEEnpBnno|ryZq#5fx'_&>00PVV~Y<0&ԉ "~?!H1XL Hk֬!}E]zi,|% 6^Vib׻gϞ`0}vVt4M&xh4?w}7QjR4M B$iii႗E ǐ% , JBZC7*iB( \!{I.Y5FWFF*'ł 'JoZN*JN)tTLXv2/nfJ旛f4$PGbjAXOt:u]~g j1ַTU%f+r\.H]]MW^YfM*=xڵkcXggm6>>OG?&BlMϸD%\ \sU mߎ~CCC9999sg{-[t:O[Z[[VXAV0KjbbḪj##ʕ+N>=22n:]ק=Z__={>>}P$ɗ뜜###Hdrr窫B6::v~ӧ7o|Ǐoٲkϧ4)V0Dld2u_W`~~}˖-d!=y :3N8aٜN'۷o'N f%ifѾp8F<O$eee///'1SssKhM,6uWmtB( MLLZ|hh( "FFF3%%%HDUղ7|8''GQ[ZZh2 PFQӹu֏>pDђEQE!u\رc.5pQaqNj"b Lp66ڌ4⎛H$.Ù̆=4V堹 ՚R*aK<g?,M+-,Hh>ryT jxD:zI? ,/e{k=#4M{ZZZ0ƿ/o`0zNNÇO8zvÇ7o\ZZz5׼K7o4maarE"ktŕW2z˗NNNE"۝_TTtС꾾믿>%%%}}}?wܙL&WZEvn],S]݉(p(Ά1ƣP윟'3YYY$q:Nɓ@ܹs v= ' FGG{zzzzzVZҲcǎ˗s΋1YFEyyy@ //|}7:0===555===22rlaaann߽{wyy|IIٺuY^{ݻ7lzsrr䲊HJK5;3WDҮ1}ww|HooڵkUUE|>=66FX$iϓ ;;;??Dcǎ555%Ǐn_~}(ztf;vEcvv7D"D"uuueeeNzHNOOa(,,,--=qD0l~?>}:l޼y||c͚5Ν&e J3Jw%)w B!Nx ®i%*m.CVf!F5jF|hF|1ZA,NjW{b(fffu$RUȑ#rMMM999T1k}ʫܹs-;X,WXXxСϟojj*((.--q:.+o޼{hhtb'&&V^H$8r|q8pح0'εYR*+G4EyXXXxwD(z'EyGFF{/EEEo7޸066nݺ˗K.ڵd۶mh?lllp\%%%---c|G-//?}ᨪrjf F xު*˵f͚]vegg? pn 充PhϞ=OɉD"[lYkk={l<]l|nnnkk+9 )pEE3DOR7JRdK(++kv{EEƍ3Q~nn]gffn& %KQ! +++KJJ8m۶h4JnsvZLJاH˵׶WB 7 Unᆱ믿>ɪ*rw󕔔dee]uUnԩSvyB)??ݺuzkGGʕ+UU BW^yeqq(++u}ڵtD$l H#!fenkD~WLą:&dHRl#q"CDjO[CwHl-JPV B: l>V,ȖzQtT02PW48qJU Ξ=iڱcn6]ׯj777Gy񪪪{QrW`PQ˗l6M֢n_XX K̙3`phF~^H&MMM.d8Lfo6뗱h*$(C رX,va =6mժUҾСC_yZy导|wϿb؉'*++TU>qv8w=ٳgO>]TTtɼg6669rdtto|wW^^[T++ۢI:% b endstream endobj 114 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 190 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 300 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 409>> stream xA 0 =fy9뀟\| endstream endobj 115 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 190 /SMask 114 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 300 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 32791>> stream x}yxUӝHA@qXePGeܝguFNjuzAP1"!@ }O'w:uͽ{|{oNw5' L /1d:&8Wzsg1@IVY_P|E8>b"iؤJqJLA<H)b؍'_2A'N̛7oo֒%K>9mڴ5kִO:urPbFzqr^.&\~ (ܨ:[^^~ي w\ǎcXd1jPJ_wuק~*YvmvvE{; ,C!U_J _@wԨQ>`}}h|z>xĉ7xc֭>… fd2\ gpz (J/UUU;yyyO<đ#GZZZ~uo)((8|~~>|Gj)n %>|ʕ+9w^qd ^ti\\\ ߿cc#.v \6aaafg}ht:]\\y~{g <ϧO6M <RcXwԨQsmkkX,sn7;::}իW^:"""???LJJ?>''Gn$rB8ظy_8{섄b7t_ױc:AN:uִ4/~ /+.Y@iQ!kiiinn.**-[._\RR2j(F3cƌ.,:} /`0x]J`"8 y)qx} JnIAxw:ތ3on2~;y$/ph4|Er0U_J+t:jjj\./_\tI'N(--Epl6ٳ\(D:;;/_z].WdddZZZmmmEEEFFFZZZMMMTTTkkkvvvEEon:b>39~N(|% }>X,b#8;w堐!YBT޶m۬Y.]T\\\__?x`JJ⮿!]@ +:riZ Ivp&BH Odt/[`0 P߽pAHұXRagڻwocccZZZ=*MġDș@ +E7|3++sa($#+@VPFҥKuuuP'9+' Rr8֭3=2W0.xT#a5SNw}wuן'v?#{98](d 2 x={vDDF( !2] 4j"/*LOO`"KJU$Pҙkמ>}dٞyp(V]]]+V'j4sr-P?7XTThnfvVZq4 6" J$Z #7,aS4|q#֔ꦛnz*ŋb P.fba v@ x *_L\Xs L . tQ c% *i8|g+abg\PQ +8U|XXXQD<0DKJ"F>QB!cMs:%Y (ZBQs=2TkPv `R,g\ vBN93 (B0Pbg@AuJKK?lܸ񔕕?nڴ'Nr>D(pC &SUY"]*..~n*¹s^z5k={_GGVh4Fjjjl,PA("S窠pX|3rDEE^<"qB[nǰbUP8+"EBQX)j 2|v=))iԨQk׮u8Ν;WXa6 ;wɓ'ڵKz&OAAh,--UK,Р4&U"… ǿ+V'lhhxꩧ =}?3XPPq\dd$<1$XXKP8+ؽyAz{{o GGG;N+-#HъRUatA֯_/={lh4O?tgggTT`ǙL& .#n9 } g]NNG}$M\p?񏽽 VS%r5^< +RV^D/o?~ڵ^zi޽ۼyo]TTsN "+R(J-+-Vg Qn8oJ`C!A.œh4cĽ+S&L0Lz7M^^>\c2я|k~y˥^__駟\.2qD+=5""~Ea.]B"A޴4шxRN5\p=Pe "+\Bbg(8}<#TWW?Syyy wqGDDDAA{N7 ^cA$nR1B /`'xҥK>hJJJRRRkkcccz-vq[ 9GQXE(9VG[nG(|"ʈ]A#EU%(Uzuk#F1B)K#;v,`N021OQZ(ăH")^_JpK'`yhdHPDV L 2DVZEPU'VrZBR$yU$;+UQF)J BB ok b\T1(FVEAϞ={3g@!@r.bwΊET TTT+WTWWy[[t_'N1};"A-qɽEJn*YQ@^p8JHٯ9Dp9r)FQBRŊ]v/O6)qI%qHTp(X#xQT|qD>q"#+l III&MڻwovvQ`̶wygҤIW\Ϝ:uj֬Yf/ 'L`7mڔ"x`vXi9KII9|IbccM&rEO v(E#]B|H Oh ɝY,O W^mhh!))vo~SVV/`ǟ;wNWMMMC+y7 ALuo-!@bcbb|>_sssLL R1"i@hD1I]X唲@f rDQ;B@V82111wqGdddootIN MMM}'bbb6l믭V )Gľ`P(PXi{ZOC #Zc({CIF㸾@ p8\.WRRv*NXtwQN"˱+R8s߾}}}}UUUFݍ6'22r*=7!!o/+= BKPjYiAyjư0d@9cdeb)@wejΝt_q08>"g(9dŋ?5y䔔򜜜BćFDD̚58#DI/H帱-\"PXi#Glhh0iiiVU lw&E6U@ ZUp(x_._6xf]DQD\<@ 5EZ( &iȐ!7nlnnÇU̝;o_{1 ~F{L@ Kb 2B-+EVTA)p䐡 8.)))###66ʕ+< ؞@BA!yŠ.Բ4nlp & iHRM @t1S7KG,((=&aUr qF(((nݻ'صk^(kYiÀt(}* gԨQuuuwzn$td/(iIQ ].ׁϟ?/\^VV8%k$s`BL3.E ;{Zv4/7Z(HFXiϝ;|\\ZeAgIbkdBt<1uԸcǎWy9="+9  wh馛f+~kL9&%JQ;ZVѣG{^'>_&':ZfBNj4qСC&&&.YDʍGDK5z@ 7"PX oBv;#TxuRz\w'xG|뭷,Yٳn͕߮;vXىw@!VĨ{N2|[{oVcc%Klܸn]bDHͨ gN8q¿o;vSlPq/qV@h ԩSW^-))L8WӳiӦÇ+Vox< 6tww_v E€RCKiPH/^gUUU&M<رcԩǏ/**,_|흝mmm;vtr ;U>?/W1BYL@ `6z=n`(nh y(JgBeM6L@<`KjpVeee-\033SjZ#B!TŞ4Q  NJEB`8.77?zn:t$oyz{o ̙xb@CCÍF#$ wT|.A[M:o޼$X 'Oo.\iӦO6-..gx O*m%L$S g@PDVZlڵQQQÆ ElAb&‡8R}QRJ 1bĨQ:::ƏoX[;+Vt: Զ YpV TUUlFi q)i+ YiGꫯqqqw_jj*L1)&!Pmءpb˖-ɐ6Er'n@I l?l6[yyyYYYBBBXX>E,P!YkQ vʔ)+V())X,F(bnĀg}"P-ܙ 6YnmZޥK"^Sl3 x3P+*CJ d|:lKLL'B!a>(FiARŊ?{쉍=sLzz- 8r7v/@!٥*aP! L9rdB!YG8,$4(Pa(D <3R@!XQY 0|e˖;V|77x+pVZءB`ŃF"[:m۶ 6X˥o6W_U-? 8\ `>l͛7Ǐ'BQOTղh  a%;jԨW.DA4zהHEw;FP!4x\qqO8q1cƬ[j'O|ŋN.M ,R"ք˗/2dȑ`"`D#|^1U7]*(Uu O~c :hРI&޽;L>>ɉ:tHUB$HdMUPS6TH=pW۷'ǁ8 ^ȬX Ȫe׮]ʼn6-'''**w4֨$P0ڪ@\,Buu3gfsOOObbb !&&d2%$$H Ciii=!5rR$()r$666644\|>%E|ʔ)_z}ff&@3ļ 0{F("#F=q1c Y&n {@U(@dz$R333_|Ԍ3fʕO=zh\bdڲe4>99`07 /^9cjp 0y#GN>}߾}Z^^^LL̂ :;;/ϝ;Ww^{F,,MHUPxK|Sg"#####G!Yv͞=;4brΊE*("Cw})rB ԨW nHq#5'!읂Z(rvmd*!)BnB%PFPxAl#Ģh4CXN(@µJDDDرcqd dMSdEӡ@J )Ry`% 2#\˱|>U &Op(wTBQX/_nY|UFaY&kZU"n,j,;+\}۟O {ܹ3(P" xG"HTy(ڪ|Bx^?糳;^Nљ3Æ#t=eJԺṳ@ṆBN/ $17PDGaeRdEd;k4_IrP+)Jvr M+| D?;=l-*ρX(^DyHCeEBRmJOfbg̣`4rO(e%,;'|C4#c%i0BBYL.Aɑ JNr*`7> vVJ=t) TX C# +]1-MRHB4PD)X( BTIJ(V yˠt֊?%Ixxxtt4Dj[iH92X|RlP]mfJdo֑H uP ~_UQ|{ FӏoR\\\hސ:  sRoh*=ؐX+R!(D+?R$V/~S) de̼a떒p؍(ΐX,(*VDq pIɉGpVH}hH΄Y! .t"Xm@ۦx<1AYmmѣG'7Y D|K^`ؖK 87\o&+|_·؜BAdAhr@,D;6mBtt4 E9=p(|۫k:v>b"&QZ7`?UN+|о=; zwm CʏHbU BXz{wH|ܤeJrȏ>i/tΛu;V X)'p i?uxGOxϪ ](*8hr A#W~/%/܇i PWd MjԑCA0;SXĶ*dVJ N5 xuY<ҥK7l9裏-ZTUUOR.,](B)R!p^ HEa.jL&p8nbq1c6m4hР0qFU 35 $V@ޟT_@X3ɼBwBb555}}} MMM]]]aaaiii TVVHRUJ IL [@YЎ*&C][[kkk{{{-˹sƍes?u <`4,J^HZo2vϷ{<k6GQWW'>[[nOv8%22R|P +2HI{EL̠b&۱cGkkkMM͛oj*AV/{N[lg}VPP )Pm5G6.$8}Ae\n۶r|lNOO_hѶm۲de;W|?hSޒ7*Š-TRBY1cTUUϝ;cРA'O3gd\z XcrŶ+8l6/[硇5L=իRSSlْaAΟ?o0ZZZCE(cX0镈1Eȏ{<$?׮]ϓ'OFFF>_nomm]re~~ܹsIX`CN.u#Y1$,`Aj |EόVw\AxM7M:bpwwssrrTWi=2A 46S8W<%8>Z9 骪\.|T`éEOH'K&ej&KӉ^u:^j>o׮]@`ĉ\cL,F ΊbB"y[W."PUxx}Q%5Ҁ/r?"5^ s;@WПӂk8p\/>>{qqqf…ӦMFf&LHLL.?iIV^%?$}3|؎{MMM7ov:e̘1.`8q &H~RѤ >x[^YzL$"+%-Ed +D ZvܹseΊӧ'%%= %%%1أZ7-g(Baxsrt:mݦh_fggƾtR"< ttVLL @w*M;|AP@ʿ1#""+2:>9I D|~`sg̘!3fLnn|qL^^f9h(@.$TR,LddY'OA)*%x%.J]ª_yz4pw,r/* o eTt2nAxׁ;n[ۀZpإbAPN nBAZIIFVL" :I4DĜtfšZio)JѐBRpoͦ dD T@–*™"$D p_$vTzE2z=B@x8i Ab3-jVž+ਓk*$ sbC ryZ  ҿ C3x+y!,pЯ2)ҭ@W2I ٚ\пTR:Ú85"3ch:qZVD f(8,=Hq&<)OI̱ؠbx\oafa_=c`SҒg Wdz 8ठBH3DT$!n9O1JI)/ҺKǰ`e1(@bJI9埧K^B$gmNgBM BLpVue͠ "V;(SB>)lBjŠ>\j ǯ2 C P~*15YL%ne",@8euUKV  /L RHKLg;q 8"äe&]/пM6QeN Pj @p(A6ĕ#]PXQ"(V@.‘=f /[FR]?G;9aa(.F7Xe:IY sD5q@Vx#bJU8WDRlnc6x 2^X)Ev`Ejle%Px(uO HJLR CIOlI\F,I7&@WFOfIyM: X))^DivdZywY2e )œFD@"9|Yq4ŕ1k#j!i;^EL_Q$ J/I1̓2w $(Fs_q) R F JNH 33m|;1b"쬈LsJ D|=!>Z자6JtW D`{͕28x(bxy<D(y$t=x 7=ˇ@X$9UԝK}9- D|5\#2iqd#5^/$r2$8rGwqY))"@+$~>8d.VHIS,d# NJ¾B; Uڈ {ݴi.\z3fIcbEP;*P,XDN;ym۶={v޽^ߤ0cEU$#$pV 5… O=>~sΝ:@^N}t ͮCU5%<].IQ[N~[=/۱mwl6V;e Dpv?}􈈈]v9}8qٳC\.Wuu袎x@t @EûAmϮ] RYY|z 8 t*P/5]ܾu%[I,zIp+@ 2&)..{ĉ_}մiħDǏ狈>|c,M7%###&&jE͞={̙$TaF.],dX{wjWUtرc䈨(N'Z4i$+sG~X,#>0??j&%%&<<74͡ߪd͡D 66O\!NIMM]bq#ocNg2:;;O:zԔ>}zAAXfwWZ4x+Ë>iӦ 6h4WXX8H\P@A | ?~?_̜93%%巿8{ 7ܠbccYpY Pħ|gGtf{Zd2%)XT%lV^"} |/N(j"ρ@rZ(@ Pnvꟁdi4(} 89YY+]X,DDd'-[SSсa+0ԩS}ݮ.i(!@!sa1x<!CK.stmngÃȶn6^|?u+i"/$xIN`rZQQSON,G ill|SSSV#GbbdH$qEI {}_{ʐ.\_3=zW~) x>^zi[!@}wȑ#[ZZ=syHrϹc Udd{{ʕ+͛WPPk׮#GZVIAVZrGMMݻ'N(>T7(BCtREEŴiÊ܁{iSɓ򦦦,Q˗/:t?SHP>FpΆ_JPDQ~]~ٳSSSGGG!M/%rAjjjZ[[_{5}>CSm82ܸqcFFƸq -5]P?Cjj={dee@ s˖-HII;doozV믿^YYyaDJd"0۽k׮HwUVV;vl6'&&5%Kz###̙h6oޜXRRx?x+kD(ݳgСC^W_}]TTt8iPSN[~ٳw޽xkʹ ;gQvt8iii_~II\*SQQYPPrNgoon7 yyyo`S.oY[[po6''/PL;b588#Twww]]]\\ѣkkk/^|ssT3fzzzbcc͛V5..#@=999''l6WVVjZm4322Բɩ5jСC<7$''[֟ ^DNruVn$Bw}wߝ3gfn6{zzlْ)_tԨÇYfٱGꊎX,_Y46\l3B?O;w5kVllȑ#ZVVp‹/fdd>}zĈdXXY,zu͙3tvvv;wnر C!⻊h;J!@ P\\/VVVN:5..nԨQGX,3gμxȑ# 222.*::z?lٲlٲcǎiڳgt:vTAuG;t)S`[Яjّ>(33fi493 sYt)󍍍UUU-7nh4{{{^ Lp'ct(@GGΝ;_xᅬ!CL8`0!!bɒ%O߻wƝь"##,Xp]w?b͘1 bZ5 I~C<q#?FHs+++;6vzh0jkk#Fx7<qرGzGGGqqE* m;QfsQQS}ܹrAءp' Iat(_RR"fW&$$N j̙8}4qVW^YvmOOυ ](2 G7o>|ԩS7lzO8Р@d ٬P.->>St:ݯ|^1g}СC555p^rҥKFݻ{{{;&@' xvT8b)((4iҕ+Wccc7ohР˟>}:qzb)~ E磣'L}FfsxxxWW?,g>}tuuu~~#P,322~_y商^z5??_#ܾB2!CNjJKKOcǎ(sjZ{zz7cƌȘ3g|aÆ1h4#F̼z3g^}Ճl3gΈq10x  9FFqw/]$7:.33sر'Nܽ{ >sA Yy￟?>hܸqyEEŤIx]DFQ<ۛ[XXwĉ^Fc4Fѣ>~[>裑VD=/:+~Ç.]j*>gΜ>hԩ˗/`7PRΑyd2i4n1cݻw{ޞɤVkAAAVVVzz{1ݾ},Aeaj;;;OfYGyo"kfIn$E'c{HV2hР{W۷ ּ;v|Dp;өju: }F ۼysvvȑ# "" HJw!kHqJWW׆ Ǝe˖NObp8zF|ӟf͚u̙iӦEEE3&99YO 9P ^zt^ܜ;|߶n:yUV-X`ǎw|1 G3ooo_b<駟9:`YP S HA$q'jZV0f̘n󵴴?~U`0̛7/77ˏ?xCCCFF裏 HF6mڔ)S~ᨨk677]xA WQoPM~~ԩSt̙)BEEEy~j~W^MKK{g/_xY8뮨~yʕ.TLD(3^FJF^djEEEv]z.q뮻Ξ=;s̼nZh4&IjjjFۿUWW777竬=@/L_3f5j|gX|Iu:nΜ9s뭷?>77xH♦G=z4 **n_xnh)))PrUh ̊:zY233}>_UUՊ+VkWWj8q\^^^UUUZZZEEENN}---<477WVV^xn]zu޼y}nOHH5^-\hPfJLLxbZZfڸq~h]jkk#""A/M&Sll^| ǎꪩ6mښ5kl6h$~H1X" k+&sgٴZmuu7޸y|paܸqv=ztaaVx衇ĺ}߾} ,ZD-f=vX@YY, S9v΁m@xٽ{#}O8Qaz}KK;wnsssuuwܱwaÆA 1i+j8 ]H BJ`ۘ-8NҴI.ɩݞ&m8icMfua'xcf@$hyLrsJ`פqp8W~o3sg E"kkký񼼼{o͜wH$ӍCCCk׮EywǕn/..KII2,H8N޶m[mmOZZڗ_~ =VD>wf苐 T* d0AAAT*[\_M|+[bp8x<_|… R.{W]sKӂKV4dϞ=B0==FwZ2plvUUUڵk=p566رcp]FS(l6[(߾}駟$  N'{Hhq1o޼)_x4y¸?77W]]-9rĄ:G 4J>}_>~X,~ꩧwx_.a"PI&ܹSPP_ҥK˗/߽{7"B62͵~auu[oG۷q\ %ڵk>>>###v:zƍ333|O(r0\;11zj4t;::R;3==#G, GzK.q8Bqܹ'xbʕP7󄘖(ڍ 0>^zX2;DC&6>#~%Ldt\.g<n+|Lvʕ1PHRI$Rxx8rR333ZFzkE+.^C wҸ(8M '>>ׯ_///h]]],+88|i.?LNN^~hrbzWhgp#t~t7hb+bؘF9pCܹsE8D. +.:fIRp(ߚ5k ^/..+**:wUTd2N# c&^( bt>{]v}>,Ћb0pET*ݾ}kLhd^^^AAAiii###nܼySR8q"55b x/+4>T*V*gϞMNNd7oLHH8|0]~=!8!x.+::GU(큁pΆ`+W޸qcrrl6߽{7<<_W]]ʕ+t !<gN<^ Ɔa|?VfsCC޽{/\&%%aD0?D#h4lȿ]]]sssaaat:=>>>,,lllNdddDRB^fA}0wHI4EPVZZZZR._k! oo^TZl6Nʕ+BFs8)))p? 5 tbXk֬pŽ;fgg>Wਨ(*,Bo=222::j6+L&Jm~~tz}}}dd Ot[{{D_m'x93̎?44gq/bkG@vɹ|#hEEEDDFH$111Ed@@񲲲֮]{;w lf???y3' @wr1g].IHH/** ߿n~&L&3))ܹs fUWWOLLD"___Lܝ#A7(.Vrss333B3<DDDD|'eee6;88٧  @bZ?W^MKK۰arI$cǎgϲ졡!B;ႍ%]|h4\.? ~߆].LSSS]詧 E֋/1( J54G~;\E*:33rkjjyH_/½a@]][(B·z`)%B errR"[bHDMQP xΆӳ{ D65p8JJJƞ|I [LCƹ9<j^p.{Wսj``}a333F 0B3=-B? s}?PNgWWE/Atz<@"Zz6 RJB(w߂\AMMM577D"BS&|f`0AQ %lŷEnk_{ZPO(*1fv}OA`n@D K V<M5 y`b EFC` ]4ڔzM6 0F$a$}[P*Y iz<B%鞔^pL̯ |+P`ov 0e3G; NiB?B o";#XxPfpеLH[o͵O###fƍ,QXXxر|ZmYYYZZZMMZn]{{F u떷wJJJccc?ܕ000PWW'rNW*$d2566666VUU={v˖-y~̙>t7,ˏ~#d!>~`ĎW9w;b 4pn.VJ兜!;22R^^c;w8޽{I$x'NWmll4111充ofFFFee}}}!⫆y׽B9N;Tx[ v0lڴI{f:><<\RR?~9rUUU9sY,~ݮ&B?td2?))ijj 0<<S._t'VpAippppppZZZGGSVV{1:WT_Zmvv பȖhᠻh/z./$Z`VswH$ʪAgddlڴp>5::t:[[[gffӷnjX"""nݚ]@rr-[;;;G:[wv柰x- UmlY%%%gΜyWSSSoܸ{T*-..NIIAXvv=333))G,wwwzF333C"G---FrMOOLx3"""##cvvvbb|]ظq[aBXVw5kքT*???| F#wFxowC# nl6oܸ155r\+VӟuVxܬN 嵶D"Fs84 Ld2X쮂*%rOPn)`_$j՝:ujǎdUUU~~~&I&mٲ%66D&}KsU,--]ltk֬xǏK$1xNѣG)_|! "&Zw 5oD4 OE :?BbѣGһrxF) ˝fvttSGXXdjkk;NNNr\(fffr9zT"=˂ۛu:@!s1G_!>.p8###&[( d&I AAApS lNc}pshZ###| fp\oooOd2R&eppp``@PD"eۜ.Y >7C^$(,11MD#,'ds3DR#}vuc!2h (0߃P=v ‹8!  6B7Z zmB @v?4KCr བ)N'SlL"H㙖P(Z1N'hqBb"Vh,h((x BLwP.A0Z{Mx%yL2L R0cff&::իJ-KKKKBB+^SS#/ގ˕B"m6J{ŵNOO'&&"SSSZ dܱl׮u77S=6o'} khhT644l:^WWt:ccc`JJJOOOOOOjj*Huu͛q&*K&Bp8n߾bVXA(<&zD-=BJ$dP^K\$WE0O^݁ XDOL0I NNN :p^|Š o߾슊Ǐ M@kk\ll,_zݿ/>bppfQԢ".jJKKsrr}]ј-++{e޽d2j5\KRihhhSSh\lGd2+|"22H**++ܹr'''\ܺuϟO^ZVVlwYzu}}zᇵZmgggHH\./--NLLlmmPTAAA333MMMQQQ˗/t]]]l0v`p:aaa:VNaÆ^GRϞ=j*oH$P(h4"N'$$TTTLOO x$lbGd28q"00BRfdd={6 ??߾}rO>d4MVs8ӧOL&8;UZZT* EAAMN<)J1ccc^z ik印KIhE8c4`1'w=X|`p@} q_8(7\VV&NVݷoɓ'ɗ/_H$W^y7|w?99rrss漼V+eXd\.՜˵}v\yڵΝ %t:c=`0wd2aꂇ;ζ6F(4`y=LFL8v믿nݺ;wd2YaaU3zuvٺukrr2ikk3&IȹBؽ{w\\ŋz=BǕӲ}ѡ`^ {fggߴׯܺunٶm[```oooww7NjpӧW\ &HcĎa^07q~0'<p5_z322'&&Zm]]J*&%%XH_rbܹ Юvի%%%~iZZZkkkTTT~~~yy\.H$p) 444;;fh4TzŎ۷LwT*.)JTT۷<}vvvj 6 3l۷o766^x133wޑ卍B'** qFZDppӧ+**`0DEE 7oō*⺺:@/YfM{{{ll7\p/HΟ??<> endobj 117 0 obj << /Length 25849 >> stream q 15.000 31.423 577.500 745.577 re W n 0.965 0.965 0.965 rg 26.250 714.941 555.000 62.059 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 714.941 m 581.250 714.941 l 581.250 715.691 l 26.250 715.691 l f q 35.250 726.191 537.000 50.809 re W n 0.271 0.267 0.267 rg BT 35.250 767.476 Td /F4 9.8 Tf [(Fig. 2: The impact on infections, deaths, and hospitalizations for different vaccine delivery schedules and different )] TJ ET BT 35.250 755.571 Td /F4 9.8 Tf [(objectives, with)] TJ ET q 47.250 0 0 13.500 35.250 733.691 cm /I38 Do Q Q BT 26.250 697.917 Td /F1 9.8 Tf [(The staggered vaccine delivery schedule that we considered had a total of 125 million doses in five batches starting on 15 )] TJ ET BT 26.250 686.012 Td /F1 9.8 Tf [(October. To explore the effect of the delay in vaccine delivery, we also calculated the optimal allocations when all 125 million )] TJ ET BT 26.250 674.107 Td /F1 9.8 Tf [(doses were delivered in one batch, either on 15 October or before the outbreak began \(Figure 1\). The epidemiological impact of )] TJ ET BT 26.250 662.202 Td /F1 9.8 Tf [(the initial vaccination delay is substantial: the staggered release results in 23% more deaths and 26% more hospitalizations, )] TJ ET BT 26.250 650.298 Td /F1 9.8 Tf [(respectively, compared to optimal allocation of the complete distribution in October. By contrast, the optimal distribution of 125 )] TJ ET BT 26.250 638.393 Td /F1 9.8 Tf [(million doses before the outbreak begins prevented the outbreak entirely \(Figure 2\).)] TJ ET BT 26.250 601.790 Td /F4 12.0 Tf [(Discussion)] TJ ET BT 26.250 581.836 Td /F1 9.8 Tf [(Vaccination not only protects those who are vaccinated, but also reduces transmission to others in the population. )] TJ ET BT 26.250 569.931 Td /F1 9.8 Tf [(Schoolchildren, and secondarily young adults, are responsible for most of the influenza transmission )] TJ ET 0.267 0.267 0.267 rg BT 460.856 569.931 Td /F1 9.8 Tf [([5])] TJ ET BT 471.698 569.931 Td /F1 9.8 Tf [([6])] TJ ET BT 482.540 569.931 Td /F1 9.8 Tf [([7])] TJ ET BT 493.382 569.931 Td /F1 9.8 Tf [([8])] TJ ET BT 504.224 569.931 Td /F1 9.8 Tf [([9])] TJ ET BT 515.066 569.931 Td /F1 9.8 Tf [([10])] TJ ET 0.271 0.267 0.267 rg BT 531.329 569.931 Td /F1 9.8 Tf [( , although )] TJ ET BT 26.250 558.027 Td /F1 9.8 Tf [(this may shift late in a pandemic after a large fraction of children have already become immune )] TJ ET 0.267 0.267 0.267 rg BT 438.090 558.027 Td /F1 9.8 Tf [([11])] TJ ET 0.271 0.267 0.267 rg BT 454.353 558.027 Td /F1 9.8 Tf [( . It has been previously )] TJ ET BT 26.250 546.122 Td /F1 9.8 Tf [(demonstrated that the vaccination of these age classes can optimize multiple outcome measures, including infections averted, )] TJ ET BT 26.250 534.217 Td /F1 9.8 Tf [(deaths averted, economic cost, and years of life saved )] TJ ET 0.267 0.267 0.267 rg BT 264.160 534.217 Td /F1 9.8 Tf [([12])] TJ ET 0.271 0.267 0.267 rg BT 280.423 534.217 Td /F1 9.8 Tf [( . However, it was previously assumed that all available vaccines )] TJ ET BT 26.250 522.312 Td /F1 9.8 Tf [(were allocated prior to the outbreak. As is the case for the current 2009 H1N1 pandemic, vaccines may not become available )] TJ ET BT 26.250 510.408 Td /F1 9.8 Tf [(until the midst of an outbreak requiring critical policy decisions under dynamic conditions. Indeed, we find that the temporal )] TJ ET BT 26.250 498.503 Td /F1 9.8 Tf [(dynamics of influenza transmission and vaccine availability affect the optimization of vaccine allocation, and that the optimal )] TJ ET BT 26.250 486.598 Td /F1 9.8 Tf [(allocation changes through time. For example, the importance of reducing transmission declines throughout the outbreak and )] TJ ET BT 26.250 474.693 Td /F1 9.8 Tf [(thus so does the value of vaccinating individuals based on their potential for transmission.)] TJ ET BT 26.250 455.289 Td /F1 9.8 Tf [(We evaluated the optimal age-specific and risk-specific allocation of 2009 H1N1 influenza vaccine doses based on the schedule )] TJ ET BT 26.250 443.384 Td /F1 9.8 Tf [(of vaccine availability projected by the CDC. In general, our results suggest that low-risk children between 6 months and 4 years )] TJ ET BT 26.250 431.479 Td /F1 9.8 Tf [(of age and adults 65 and older should receive the lowest priority to minimize both hospitalizations and deaths. These groups are )] TJ ET BT 26.250 419.574 Td /F1 9.8 Tf [(the least responsible for transmission, and are estimated to have relatively low case mortality ratios for 2009 H1N1 )] TJ ET 0.267 0.267 0.267 rg BT 522.067 419.574 Td /F1 9.8 Tf [([13])] TJ ET 0.271 0.267 0.267 rg BT 538.330 419.574 Td /F1 9.8 Tf [( . )] TJ ET BT 26.250 407.670 Td /F1 9.8 Tf [(Although hospitalization ratios are higher in high-risk people, vaccination of low-risk schoolchildren and young-adult age classes )] TJ ET BT 26.250 395.765 Td /F1 9.8 Tf [(is most effective at minimizing hospitalizations, via reducing transmission, thereby indirectly protecting high-risk people. For )] TJ ET BT 26.250 383.860 Td /F1 9.8 Tf [(staggered vaccine release, after a large fraction of schoolchildren and young adults have been vaccinated, adults aged 45-64 )] TJ ET BT 26.250 371.955 Td /F1 9.8 Tf [(years should then be vaccinated. In order to reduce deaths, high-risk people should be given priority, followed by the )] TJ ET BT 26.250 360.051 Td /F1 9.8 Tf [(schoolchildren and then young adults. Deaths are minimized by protecting the high-risk group directly.)] TJ ET BT 26.250 340.646 Td /F1 9.8 Tf [(Despite the current stage of the 2009 H1N1 outbreak, the vaccination of those most responsible for transmission remains )] TJ ET BT 26.250 328.741 Td /F1 9.8 Tf [(important. For diseases that are more transmissible than the current 2009 H1N1 influenza, and particularly if vaccination is not )] TJ ET BT 26.250 316.836 Td /F1 9.8 Tf [(available early on during the outbreak, control of the outbreak via the reduction of transmission becomes very difficult, )] TJ ET BT 26.250 303.656 Td /F1 9.8 Tf [(increasing the importance of vaccinating high-risk people \(e.g. Figures S1 & S2 for )] TJ ET q 48.000 0 0 13.500 384.445 300.956 cm /I40 Do Q BT 432.445 303.656 Td /F1 9.8 Tf [(\).)] TJ ET BT 26.250 283.932 Td /F1 9.8 Tf [(The CDC issued 2009 H1N1 vaccine guidelines in late July 2009 )] TJ ET 0.267 0.267 0.267 rg BT 308.035 283.932 Td /F1 9.8 Tf [([4])] TJ ET 0.271 0.267 0.267 rg BT 318.877 283.932 Td /F1 9.8 Tf [( , which prioritized high-risk people \(including pregnant )] TJ ET BT 26.250 272.027 Td /F1 9.8 Tf [(women\) and people aged 6 months through 24 years, in addition to health-care workers and the contacts of children under 6 )] TJ ET BT 26.250 260.122 Td /F1 9.8 Tf [(months of age. Our analysis suggests a different strategy is optimal. If the public health objective is to minimize deaths due to )] TJ ET BT 26.250 248.217 Td /F1 9.8 Tf [(2009 H1N1, earliest priority should be given to high-risk people, followed by school-aged children and then young adults \(18-44 )] TJ ET BT 26.250 236.313 Td /F1 9.8 Tf [(years old\). In contrast, if the public health objective is to minimize hospitalizations, only school-aged children and then young )] TJ ET BT 26.250 224.408 Td /F1 9.8 Tf [(adults, with only a small fraction of the supply finally going to high-risk people. These optimal vaccine allocations differ from the )] TJ ET BT 26.250 212.503 Td /F1 9.8 Tf [(CDC recommendations by excluding children aged 6 months to 4 years and including adults aged 25-44. Even under the early )] TJ ET BT 26.250 200.598 Td /F1 9.8 Tf [(vaccine delivery scenarios, we find that priority should still be given to high-risk people, schoolchildren and young adults, and )] TJ ET BT 26.250 188.694 Td /F1 9.8 Tf [(not to individuals aged 6 months to 4 years and 25-44 years.)] TJ ET BT 26.250 169.289 Td /F1 9.8 Tf [(We have found that the entire epidemic period must be considered in order to determine optimal vaccine allocations when )] TJ ET BT 26.250 157.384 Td /F1 9.8 Tf [(availability is staggered. In contrast to traditional epidemic models, our optimization methodology allows the scheduling of )] TJ ET BT 26.250 145.479 Td /F1 9.8 Tf [(vaccine availability to be taken into account. The methodology developed here is broadly applicable. It can be used for other )] TJ ET BT 26.250 133.575 Td /F1 9.8 Tf [(infectious-disease outbreaks in which not all supplies, whether vaccines or drugs, are available at the start of the epidemic.)] TJ ET BT 26.250 96.972 Td /F4 12.0 Tf [(Methods)] TJ ET Q q 15.000 31.423 577.500 745.577 re W n 0.965 0.965 0.965 rg 26.250 714.941 555.000 62.059 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 714.941 m 581.250 714.941 l 581.250 715.691 l 26.250 715.691 l f q 35.250 726.191 537.000 50.809 re W n 0.271 0.267 0.267 rg BT 35.250 767.476 Td /F4 9.8 Tf [(Fig. 2: The impact on infections, deaths, and hospitalizations for different vaccine delivery schedules and different )] TJ ET BT 35.250 755.571 Td /F4 9.8 Tf [(objectives, with)] TJ ET q 47.250 0 0 13.500 35.250 733.691 cm /I42 Do Q Q BT 26.250 697.917 Td /F1 9.8 Tf [(The staggered vaccine delivery schedule that we considered had a total of 125 million doses in five batches starting on 15 )] TJ ET BT 26.250 686.012 Td /F1 9.8 Tf [(October. To explore the effect of the delay in vaccine delivery, we also calculated the optimal allocations when all 125 million )] TJ ET BT 26.250 674.107 Td /F1 9.8 Tf [(doses were delivered in one batch, either on 15 October or before the outbreak began \(Figure 1\). The epidemiological impact of )] TJ ET BT 26.250 662.202 Td /F1 9.8 Tf [(the initial vaccination delay is substantial: the staggered release results in 23% more deaths and 26% more hospitalizations, )] TJ ET BT 26.250 650.298 Td /F1 9.8 Tf [(respectively, compared to optimal allocation of the complete distribution in October. By contrast, the optimal distribution of 125 )] TJ ET BT 26.250 638.393 Td /F1 9.8 Tf [(million doses before the outbreak begins prevented the outbreak entirely \(Figure 2\).)] TJ ET BT 26.250 601.790 Td /F4 12.0 Tf [(Discussion)] TJ ET BT 26.250 581.836 Td /F1 9.8 Tf [(Vaccination not only protects those who are vaccinated, but also reduces transmission to others in the population. )] TJ ET BT 26.250 569.931 Td /F1 9.8 Tf [(Schoolchildren, and secondarily young adults, are responsible for most of the influenza transmission )] TJ ET 0.267 0.267 0.267 rg BT 460.856 569.931 Td /F1 9.8 Tf [([5])] TJ ET BT 471.698 569.931 Td /F1 9.8 Tf [([6])] TJ ET BT 482.540 569.931 Td /F1 9.8 Tf [([7])] TJ ET BT 493.382 569.931 Td /F1 9.8 Tf [([8])] TJ ET BT 504.224 569.931 Td /F1 9.8 Tf [([9])] TJ ET BT 515.066 569.931 Td /F1 9.8 Tf [([10])] TJ ET 0.271 0.267 0.267 rg BT 531.329 569.931 Td /F1 9.8 Tf [( , although )] TJ ET BT 26.250 558.027 Td /F1 9.8 Tf [(this may shift late in a pandemic after a large fraction of children have already become immune )] TJ ET 0.267 0.267 0.267 rg BT 438.090 558.027 Td /F1 9.8 Tf [([11])] TJ ET 0.271 0.267 0.267 rg BT 454.353 558.027 Td /F1 9.8 Tf [( . It has been previously )] TJ ET BT 26.250 546.122 Td /F1 9.8 Tf [(demonstrated that the vaccination of these age classes can optimize multiple outcome measures, including infections averted, )] TJ ET BT 26.250 534.217 Td /F1 9.8 Tf [(deaths averted, economic cost, and years of life saved )] TJ ET 0.267 0.267 0.267 rg BT 264.160 534.217 Td /F1 9.8 Tf [([12])] TJ ET 0.271 0.267 0.267 rg BT 280.423 534.217 Td /F1 9.8 Tf [( . However, it was previously assumed that all available vaccines )] TJ ET BT 26.250 522.312 Td /F1 9.8 Tf [(were allocated prior to the outbreak. As is the case for the current 2009 H1N1 pandemic, vaccines may not become available )] TJ ET BT 26.250 510.408 Td /F1 9.8 Tf [(until the midst of an outbreak requiring critical policy decisions under dynamic conditions. Indeed, we find that the temporal )] TJ ET BT 26.250 498.503 Td /F1 9.8 Tf [(dynamics of influenza transmission and vaccine availability affect the optimization of vaccine allocation, and that the optimal )] TJ ET BT 26.250 486.598 Td /F1 9.8 Tf [(allocation changes through time. For example, the importance of reducing transmission declines throughout the outbreak and )] TJ ET BT 26.250 474.693 Td /F1 9.8 Tf [(thus so does the value of vaccinating individuals based on their potential for transmission.)] TJ ET BT 26.250 455.289 Td /F1 9.8 Tf [(We evaluated the optimal age-specific and risk-specific allocation of 2009 H1N1 influenza vaccine doses based on the schedule )] TJ ET BT 26.250 443.384 Td /F1 9.8 Tf [(of vaccine availability projected by the CDC. In general, our results suggest that low-risk children between 6 months and 4 years )] TJ ET BT 26.250 431.479 Td /F1 9.8 Tf [(of age and adults 65 and older should receive the lowest priority to minimize both hospitalizations and deaths. These groups are )] TJ ET BT 26.250 419.574 Td /F1 9.8 Tf [(the least responsible for transmission, and are estimated to have relatively low case mortality ratios for 2009 H1N1 )] TJ ET 0.267 0.267 0.267 rg BT 522.067 419.574 Td /F1 9.8 Tf [([13])] TJ ET 0.271 0.267 0.267 rg BT 538.330 419.574 Td /F1 9.8 Tf [( . )] TJ ET BT 26.250 407.670 Td /F1 9.8 Tf [(Although hospitalization ratios are higher in high-risk people, vaccination of low-risk schoolchildren and young-adult age classes )] TJ ET BT 26.250 395.765 Td /F1 9.8 Tf [(is most effective at minimizing hospitalizations, via reducing transmission, thereby indirectly protecting high-risk people. For )] TJ ET BT 26.250 383.860 Td /F1 9.8 Tf [(staggered vaccine release, after a large fraction of schoolchildren and young adults have been vaccinated, adults aged 45-64 )] TJ ET BT 26.250 371.955 Td /F1 9.8 Tf [(years should then be vaccinated. In order to reduce deaths, high-risk people should be given priority, followed by the )] TJ ET BT 26.250 360.051 Td /F1 9.8 Tf [(schoolchildren and then young adults. Deaths are minimized by protecting the high-risk group directly.)] TJ ET BT 26.250 340.646 Td /F1 9.8 Tf [(Despite the current stage of the 2009 H1N1 outbreak, the vaccination of those most responsible for transmission remains )] TJ ET BT 26.250 328.741 Td /F1 9.8 Tf [(important. For diseases that are more transmissible than the current 2009 H1N1 influenza, and particularly if vaccination is not )] TJ ET BT 26.250 316.836 Td /F1 9.8 Tf [(available early on during the outbreak, control of the outbreak via the reduction of transmission becomes very difficult, )] TJ ET BT 26.250 303.656 Td /F1 9.8 Tf [(increasing the importance of vaccinating high-risk people \(e.g. Figures S1 & S2 for )] TJ ET q 48.000 0 0 13.500 384.445 300.956 cm /I44 Do Q BT 432.445 303.656 Td /F1 9.8 Tf [(\).)] TJ ET BT 26.250 283.932 Td /F1 9.8 Tf [(The CDC issued 2009 H1N1 vaccine guidelines in late July 2009 )] TJ ET 0.267 0.267 0.267 rg BT 308.035 283.932 Td /F1 9.8 Tf [([4])] TJ ET 0.271 0.267 0.267 rg BT 318.877 283.932 Td /F1 9.8 Tf [( , which prioritized high-risk people \(including pregnant )] TJ ET BT 26.250 272.027 Td /F1 9.8 Tf [(women\) and people aged 6 months through 24 years, in addition to health-care workers and the contacts of children under 6 )] TJ ET BT 26.250 260.122 Td /F1 9.8 Tf [(months of age. Our analysis suggests a different strategy is optimal. If the public health objective is to minimize deaths due to )] TJ ET BT 26.250 248.217 Td /F1 9.8 Tf [(2009 H1N1, earliest priority should be given to high-risk people, followed by school-aged children and then young adults \(18-44 )] TJ ET BT 26.250 236.313 Td /F1 9.8 Tf [(years old\). In contrast, if the public health objective is to minimize hospitalizations, only school-aged children and then young )] TJ ET BT 26.250 224.408 Td /F1 9.8 Tf [(adults, with only a small fraction of the supply finally going to high-risk people. These optimal vaccine allocations differ from the )] TJ ET BT 26.250 212.503 Td /F1 9.8 Tf [(CDC recommendations by excluding children aged 6 months to 4 years and including adults aged 25-44. Even under the early )] TJ ET BT 26.250 200.598 Td /F1 9.8 Tf [(vaccine delivery scenarios, we find that priority should still be given to high-risk people, schoolchildren and young adults, and )] TJ ET BT 26.250 188.694 Td /F1 9.8 Tf [(not to individuals aged 6 months to 4 years and 25-44 years.)] TJ ET BT 26.250 169.289 Td /F1 9.8 Tf [(We have found that the entire epidemic period must be considered in order to determine optimal vaccine allocations when )] TJ ET BT 26.250 157.384 Td /F1 9.8 Tf [(availability is staggered. In contrast to traditional epidemic models, our optimization methodology allows the scheduling of )] TJ ET BT 26.250 145.479 Td /F1 9.8 Tf [(vaccine availability to be taken into account. The methodology developed here is broadly applicable. It can be used for other )] TJ ET BT 26.250 133.575 Td /F1 9.8 Tf [(infectious-disease outbreaks in which not all supplies, whether vaccines or drugs, are available at the start of the epidemic.)] TJ ET BT 26.250 96.972 Td /F4 12.0 Tf [(Methods)] TJ ET Q q 15.000 31.423 577.500 745.577 re W n 0.965 0.965 0.965 rg 26.250 714.941 555.000 62.059 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 714.941 m 581.250 714.941 l 581.250 715.691 l 26.250 715.691 l f q 35.250 726.191 537.000 50.809 re W n 0.271 0.267 0.267 rg BT 35.250 767.476 Td /F4 9.8 Tf [(Fig. 2: The impact on infections, deaths, and hospitalizations for different vaccine delivery schedules and different )] TJ ET BT 35.250 755.571 Td /F4 9.8 Tf [(objectives, with)] TJ ET q 47.250 0 0 13.500 35.250 733.691 cm /I46 Do Q Q BT 26.250 697.917 Td /F1 9.8 Tf [(The staggered vaccine delivery schedule that we considered had a total of 125 million doses in five batches starting on 15 )] TJ ET BT 26.250 686.012 Td /F1 9.8 Tf [(October. To explore the effect of the delay in vaccine delivery, we also calculated the optimal allocations when all 125 million )] TJ ET BT 26.250 674.107 Td /F1 9.8 Tf [(doses were delivered in one batch, either on 15 October or before the outbreak began \(Figure 1\). The epidemiological impact of )] TJ ET BT 26.250 662.202 Td /F1 9.8 Tf [(the initial vaccination delay is substantial: the staggered release results in 23% more deaths and 26% more hospitalizations, )] TJ ET BT 26.250 650.298 Td /F1 9.8 Tf [(respectively, compared to optimal allocation of the complete distribution in October. By contrast, the optimal distribution of 125 )] TJ ET BT 26.250 638.393 Td /F1 9.8 Tf [(million doses before the outbreak begins prevented the outbreak entirely \(Figure 2\).)] TJ ET BT 26.250 601.790 Td /F4 12.0 Tf [(Discussion)] TJ ET BT 26.250 581.836 Td /F1 9.8 Tf [(Vaccination not only protects those who are vaccinated, but also reduces transmission to others in the population. )] TJ ET BT 26.250 569.931 Td /F1 9.8 Tf [(Schoolchildren, and secondarily young adults, are responsible for most of the influenza transmission )] TJ ET 0.267 0.267 0.267 rg BT 460.856 569.931 Td /F1 9.8 Tf [([5])] TJ ET BT 471.698 569.931 Td /F1 9.8 Tf [([6])] TJ ET BT 482.540 569.931 Td /F1 9.8 Tf [([7])] TJ ET BT 493.382 569.931 Td /F1 9.8 Tf [([8])] TJ ET BT 504.224 569.931 Td /F1 9.8 Tf [([9])] TJ ET BT 515.066 569.931 Td /F1 9.8 Tf [([10])] TJ ET 0.271 0.267 0.267 rg BT 531.329 569.931 Td /F1 9.8 Tf [( , although )] TJ ET BT 26.250 558.027 Td /F1 9.8 Tf [(this may shift late in a pandemic after a large fraction of children have already become immune )] TJ ET 0.267 0.267 0.267 rg BT 438.090 558.027 Td /F1 9.8 Tf [([11])] TJ ET 0.271 0.267 0.267 rg BT 454.353 558.027 Td /F1 9.8 Tf [( . It has been previously )] TJ ET BT 26.250 546.122 Td /F1 9.8 Tf [(demonstrated that the vaccination of these age classes can optimize multiple outcome measures, including infections averted, )] TJ ET BT 26.250 534.217 Td /F1 9.8 Tf [(deaths averted, economic cost, and years of life saved )] TJ ET 0.267 0.267 0.267 rg BT 264.160 534.217 Td /F1 9.8 Tf [([12])] TJ ET 0.271 0.267 0.267 rg BT 280.423 534.217 Td /F1 9.8 Tf [( . However, it was previously assumed that all available vaccines )] TJ ET BT 26.250 522.312 Td /F1 9.8 Tf [(were allocated prior to the outbreak. As is the case for the current 2009 H1N1 pandemic, vaccines may not become available )] TJ ET BT 26.250 510.408 Td /F1 9.8 Tf [(until the midst of an outbreak requiring critical policy decisions under dynamic conditions. Indeed, we find that the temporal )] TJ ET BT 26.250 498.503 Td /F1 9.8 Tf [(dynamics of influenza transmission and vaccine availability affect the optimization of vaccine allocation, and that the optimal )] TJ ET BT 26.250 486.598 Td /F1 9.8 Tf [(allocation changes through time. For example, the importance of reducing transmission declines throughout the outbreak and )] TJ ET BT 26.250 474.693 Td /F1 9.8 Tf [(thus so does the value of vaccinating individuals based on their potential for transmission.)] TJ ET BT 26.250 455.289 Td /F1 9.8 Tf [(We evaluated the optimal age-specific and risk-specific allocation of 2009 H1N1 influenza vaccine doses based on the schedule )] TJ ET BT 26.250 443.384 Td /F1 9.8 Tf [(of vaccine availability projected by the CDC. In general, our results suggest that low-risk children between 6 months and 4 years )] TJ ET BT 26.250 431.479 Td /F1 9.8 Tf [(of age and adults 65 and older should receive the lowest priority to minimize both hospitalizations and deaths. These groups are )] TJ ET BT 26.250 419.574 Td /F1 9.8 Tf [(the least responsible for transmission, and are estimated to have relatively low case mortality ratios for 2009 H1N1 )] TJ ET 0.267 0.267 0.267 rg BT 522.067 419.574 Td /F1 9.8 Tf [([13])] TJ ET 0.271 0.267 0.267 rg BT 538.330 419.574 Td /F1 9.8 Tf [( . )] TJ ET BT 26.250 407.670 Td /F1 9.8 Tf [(Although hospitalization ratios are higher in high-risk people, vaccination of low-risk schoolchildren and young-adult age classes )] TJ ET BT 26.250 395.765 Td /F1 9.8 Tf [(is most effective at minimizing hospitalizations, via reducing transmission, thereby indirectly protecting high-risk people. For )] TJ ET BT 26.250 383.860 Td /F1 9.8 Tf [(staggered vaccine release, after a large fraction of schoolchildren and young adults have been vaccinated, adults aged 45-64 )] TJ ET BT 26.250 371.955 Td /F1 9.8 Tf [(years should then be vaccinated. In order to reduce deaths, high-risk people should be given priority, followed by the )] TJ ET BT 26.250 360.051 Td /F1 9.8 Tf [(schoolchildren and then young adults. Deaths are minimized by protecting the high-risk group directly.)] TJ ET BT 26.250 340.646 Td /F1 9.8 Tf [(Despite the current stage of the 2009 H1N1 outbreak, the vaccination of those most responsible for transmission remains )] TJ ET BT 26.250 328.741 Td /F1 9.8 Tf [(important. For diseases that are more transmissible than the current 2009 H1N1 influenza, and particularly if vaccination is not )] TJ ET BT 26.250 316.836 Td /F1 9.8 Tf [(available early on during the outbreak, control of the outbreak via the reduction of transmission becomes very difficult, )] TJ ET BT 26.250 303.656 Td /F1 9.8 Tf [(increasing the importance of vaccinating high-risk people \(e.g. Figures S1 & S2 for )] TJ ET q 48.000 0 0 13.500 384.445 300.956 cm /I48 Do Q BT 432.445 303.656 Td /F1 9.8 Tf [(\).)] TJ ET BT 26.250 283.932 Td /F1 9.8 Tf [(The CDC issued 2009 H1N1 vaccine guidelines in late July 2009 )] TJ ET 0.267 0.267 0.267 rg BT 308.035 283.932 Td /F1 9.8 Tf [([4])] TJ ET 0.271 0.267 0.267 rg BT 318.877 283.932 Td /F1 9.8 Tf [( , which prioritized high-risk people \(including pregnant )] TJ ET BT 26.250 272.027 Td /F1 9.8 Tf [(women\) and people aged 6 months through 24 years, in addition to health-care workers and the contacts of children under 6 )] TJ ET BT 26.250 260.122 Td /F1 9.8 Tf [(months of age. Our analysis suggests a different strategy is optimal. If the public health objective is to minimize deaths due to )] TJ ET BT 26.250 248.217 Td /F1 9.8 Tf [(2009 H1N1, earliest priority should be given to high-risk people, followed by school-aged children and then young adults \(18-44 )] TJ ET BT 26.250 236.313 Td /F1 9.8 Tf [(years old\). In contrast, if the public health objective is to minimize hospitalizations, only school-aged children and then young )] TJ ET BT 26.250 224.408 Td /F1 9.8 Tf [(adults, with only a small fraction of the supply finally going to high-risk people. These optimal vaccine allocations differ from the )] TJ ET BT 26.250 212.503 Td /F1 9.8 Tf [(CDC recommendations by excluding children aged 6 months to 4 years and including adults aged 25-44. Even under the early )] TJ ET BT 26.250 200.598 Td /F1 9.8 Tf [(vaccine delivery scenarios, we find that priority should still be given to high-risk people, schoolchildren and young adults, and )] TJ ET BT 26.250 188.694 Td /F1 9.8 Tf [(not to individuals aged 6 months to 4 years and 25-44 years.)] TJ ET BT 26.250 169.289 Td /F1 9.8 Tf [(We have found that the entire epidemic period must be considered in order to determine optimal vaccine allocations when )] TJ ET BT 26.250 157.384 Td /F1 9.8 Tf [(availability is staggered. In contrast to traditional epidemic models, our optimization methodology allows the scheduling of )] TJ ET BT 26.250 145.479 Td /F1 9.8 Tf [(vaccine availability to be taken into account. The methodology developed here is broadly applicable. It can be used for other )] TJ ET BT 26.250 133.575 Td /F1 9.8 Tf [(infectious-disease outbreaks in which not all supplies, whether vaccines or drugs, are available at the start of the epidemic.)] TJ ET BT 26.250 96.972 Td /F4 12.0 Tf [(Methods)] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(3)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Influenza)] TJ ET Q endstream endobj 118 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 391>> stream 8c`0b p@(mftt,[BH d>(k> Ys) 'S0lQJgbhCTƹ6w!~$,`sI H_s3z**E*P-@ 6m NPLTUHy@bR$-cٯqHq"f]0VA\=t@ǎaC!l)++;ה>(!m9%$SŒ)`@(4,@sIcB׀T@I?KO?&s3lxvbaBZ609ZK0```/SX) D?GV$1!_Ҕ"\ =" endstream endobj 119 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /SMask 118 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om_x \ endstream endobj 120 0 obj << /Type /Annot /Subtype /Link /A 121 0 R /Border [0 0 0] /H /I /Rect [ 460.8562 569.0296 471.6982 578.9502 ] >> endobj 121 0 obj << /Type /Action >> endobj 122 0 obj << /Type /Annot /Subtype /Link /A 123 0 R /Border [0 0 0] /H /I /Rect [ 471.6982 569.0296 482.5402 578.9502 ] >> endobj 123 0 obj << /Type /Action >> endobj 124 0 obj << /Type /Annot /Subtype /Link /A 125 0 R /Border [0 0 0] /H /I /Rect [ 482.5402 569.0296 493.3822 578.9502 ] >> endobj 125 0 obj << /Type /Action >> endobj 126 0 obj << /Type /Annot /Subtype /Link /A 127 0 R /Border [0 0 0] /H /I /Rect [ 493.3822 569.0296 504.2242 578.9502 ] >> endobj 127 0 obj << /Type /Action >> endobj 128 0 obj << /Type /Annot /Subtype /Link /A 129 0 R /Border [0 0 0] /H /I /Rect [ 504.2242 569.0296 515.0662 578.9502 ] >> endobj 129 0 obj << /Type /Action >> endobj 130 0 obj << /Type /Annot /Subtype /Link /A 131 0 R /Border [0 0 0] /H /I /Rect [ 515.0662 569.0296 531.3292 578.9502 ] >> endobj 131 0 obj << /Type /Action >> endobj 132 0 obj << /Type /Annot /Subtype /Link /A 133 0 R /Border [0 0 0] /H /I /Rect [ 438.0900 557.1248 454.3530 567.0454 ] >> endobj 133 0 obj << /Type /Action >> endobj 134 0 obj << /Type /Annot /Subtype /Link /A 135 0 R /Border [0 0 0] /H /I /Rect [ 264.1598 533.3153 280.4228 543.2359 ] >> endobj 135 0 obj << /Type /Action >> endobj 136 0 obj << /Type /Annot /Subtype /Link /A 137 0 R /Border [0 0 0] /H /I /Rect [ 522.0667 418.6726 538.3297 428.5932 ] >> endobj 137 0 obj << /Type /Action >> endobj 138 0 obj << /Type /XObject /Subtype /Image /Width 64 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 64 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 446>> stream 8SgBQ\CCzf2CIafzLCd$WL2$Ir:sʵY9~|.Bda-\*_v|%OJ45+rV;2w,pfzYbܣ`hPI \d"bQ}RdARˠFIZ'{jlhp%d enڡ۝ꦿ[:B5F[0f2屟G~cU~H;)A\ڨŀ u[ւ2 gw*;slFK"]$L)Mrbo!G[ Y!>Sê_> IJ Tr ~G]*F YrVk͔$-Р^Ŀ@IyUeR[#D? endstream endobj 139 0 obj << /Type /XObject /Subtype /Image /Width 64 /Height 18 /SMask 138 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 64 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om   endstream endobj 140 0 obj << /Type /Annot /Subtype /Link /A 141 0 R /Border [0 0 0] /H /I /Rect [ 308.0347 283.0298 318.8767 292.9505 ] >> endobj 141 0 obj << /Type /Action >> endobj 142 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 391>> stream 8c`0b p@(mftt,[BH d>(k> Ys) 'S0lQJgbhCTƹ6w!~$,`sI H_s3z**E*P-@ 6m NPLTUHy@bR$-cٯqHq"f]0VA\=t@ǎaC!l)++;ה>(!m9%$SŒ)`@(4,@sIcB׀T@I?KO?&s3lxvbaBZ609ZK0```/SX) D?GV$1!_Ҕ"\ =" endstream endobj 143 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /SMask 142 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om_x \ endstream endobj 144 0 obj << /Type /Annot /Subtype /Link /A 145 0 R /Border [0 0 0] /H /I /Rect [ 460.8562 569.0296 471.6982 578.9502 ] >> endobj 145 0 obj << /Type /Action >> endobj 146 0 obj << /Type /Annot /Subtype /Link /A 147 0 R /Border [0 0 0] /H /I /Rect [ 471.6982 569.0296 482.5402 578.9502 ] >> endobj 147 0 obj << /Type /Action >> endobj 148 0 obj << /Type /Annot /Subtype /Link /A 149 0 R /Border [0 0 0] /H /I /Rect [ 482.5402 569.0296 493.3822 578.9502 ] >> endobj 149 0 obj << /Type /Action >> endobj 150 0 obj << /Type /Annot /Subtype /Link /A 151 0 R /Border [0 0 0] /H /I /Rect [ 493.3822 569.0296 504.2242 578.9502 ] >> endobj 151 0 obj << /Type /Action >> endobj 152 0 obj << /Type /Annot /Subtype /Link /A 153 0 R /Border [0 0 0] /H /I /Rect [ 504.2242 569.0296 515.0662 578.9502 ] >> endobj 153 0 obj << /Type /Action >> endobj 154 0 obj << /Type /Annot /Subtype /Link /A 155 0 R /Border [0 0 0] /H /I /Rect [ 515.0662 569.0296 531.3292 578.9502 ] >> endobj 155 0 obj << /Type /Action >> endobj 156 0 obj << /Type /Annot /Subtype /Link /A 157 0 R /Border [0 0 0] /H /I /Rect [ 438.0900 557.1248 454.3530 567.0454 ] >> endobj 157 0 obj << /Type /Action >> endobj 158 0 obj << /Type /Annot /Subtype /Link /A 159 0 R /Border [0 0 0] /H /I /Rect [ 264.1598 533.3153 280.4228 543.2359 ] >> endobj 159 0 obj << /Type /Action >> endobj 160 0 obj << /Type /Annot /Subtype /Link /A 161 0 R /Border [0 0 0] /H /I /Rect [ 522.0667 418.6726 538.3297 428.5932 ] >> endobj 161 0 obj << /Type /Action >> endobj 162 0 obj << /Type /XObject /Subtype /Image /Width 64 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 64 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 446>> stream 8SgBQ\CCzf2CIafzLCd$WL2$Ir:sʵY9~|.Bda-\*_v|%OJ45+rV;2w,pfzYbܣ`hPI \d"bQ}RdARˠFIZ'{jlhp%d enڡ۝ꦿ[:B5F[0f2屟G~cU~H;)A\ڨŀ u[ւ2 gw*;slFK"]$L)Mrbo!G[ Y!>Sê_> IJ Tr ~G]*F YrVk͔$-Р^Ŀ@IyUeR[#D? endstream endobj 163 0 obj << /Type /XObject /Subtype /Image /Width 64 /Height 18 /SMask 162 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 64 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om   endstream endobj 164 0 obj << /Type /Annot /Subtype /Link /A 165 0 R /Border [0 0 0] /H /I /Rect [ 308.0347 283.0298 318.8767 292.9505 ] >> endobj 165 0 obj << /Type /Action >> endobj 166 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 391>> stream 8c`0b p@(mftt,[BH d>(k> Ys) 'S0lQJgbhCTƹ6w!~$,`sI H_s3z**E*P-@ 6m NPLTUHy@bR$-cٯqHq"f]0VA\=t@ǎaC!l)++;ה>(!m9%$SŒ)`@(4,@sIcB׀T@I?KO?&s3lxvbaBZ609ZK0```/SX) D?GV$1!_Ҕ"\ =" endstream endobj 167 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /SMask 166 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om_x \ endstream endobj 168 0 obj << /Type /Annot /Subtype /Link /A 169 0 R /Border [0 0 0] /H /I /Rect [ 460.8562 569.0296 471.6982 578.9502 ] >> endobj 169 0 obj << /Type /Action >> endobj 170 0 obj << /Type /Annot /Subtype /Link /A 171 0 R /Border [0 0 0] /H /I /Rect [ 471.6982 569.0296 482.5402 578.9502 ] >> endobj 171 0 obj << /Type /Action >> endobj 172 0 obj << /Type /Annot /Subtype /Link /A 173 0 R /Border [0 0 0] /H /I /Rect [ 482.5402 569.0296 493.3822 578.9502 ] >> endobj 173 0 obj << /Type /Action >> endobj 174 0 obj << /Type /Annot /Subtype /Link /A 175 0 R /Border [0 0 0] /H /I /Rect [ 493.3822 569.0296 504.2242 578.9502 ] >> endobj 175 0 obj << /Type /Action >> endobj 176 0 obj << /Type /Annot /Subtype /Link /A 177 0 R /Border [0 0 0] /H /I /Rect [ 504.2242 569.0296 515.0662 578.9502 ] >> endobj 177 0 obj << /Type /Action >> endobj 178 0 obj << /Type /Annot /Subtype /Link /A 179 0 R /Border [0 0 0] /H /I /Rect [ 515.0662 569.0296 531.3292 578.9502 ] >> endobj 179 0 obj << /Type /Action >> endobj 180 0 obj << /Type /Annot /Subtype /Link /A 181 0 R /Border [0 0 0] /H /I /Rect [ 438.0900 557.1248 454.3530 567.0454 ] >> endobj 181 0 obj << /Type /Action >> endobj 182 0 obj << /Type /Annot /Subtype /Link /A 183 0 R /Border [0 0 0] /H /I /Rect [ 264.1598 533.3153 280.4228 543.2359 ] >> endobj 183 0 obj << /Type /Action >> endobj 184 0 obj << /Type /Annot /Subtype /Link /A 185 0 R /Border [0 0 0] /H /I /Rect [ 522.0667 418.6726 538.3297 428.5932 ] >> endobj 185 0 obj << /Type /Action >> endobj 186 0 obj << /Type /XObject /Subtype /Image /Width 64 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 64 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 446>> stream 8SgBQ\CCzf2CIafzLCd$WL2$Ir:sʵY9~|.Bda-\*_v|%OJ45+rV;2w,pfzYbܣ`hPI \d"bQ}RdARˠFIZ'{jlhp%d enڡ۝ꦿ[:B5F[0f2屟G~cU~H;)A\ڨŀ u[ւ2 gw*;slFK"]$L)Mrbo!G[ Y!>Sê_> IJ Tr ~G]*F YrVk͔$-Р^Ŀ@IyUeR[#D? endstream endobj 187 0 obj << /Type /XObject /Subtype /Image /Width 64 /Height 18 /SMask 186 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 64 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om   endstream endobj 188 0 obj << /Type /Annot /Subtype /Link /A 189 0 R /Border [0 0 0] /H /I /Rect [ 308.0347 283.0298 318.8767 292.9505 ] >> endobj 189 0 obj << /Type /Action >> endobj 190 0 obj << /Type /Page /Parent 3 0 R /Annots [ 192 0 R 194 0 R 196 0 R 198 0 R 200 0 R 202 0 R 204 0 R 206 0 R 212 0 R 220 0 R 222 0 R 224 0 R 226 0 R 228 0 R 238 0 R 246 0 R 250 0 R 252 0 R 254 0 R 256 0 R 258 0 R 260 0 R 262 0 R 264 0 R 270 0 R 278 0 R 280 0 R 282 0 R 284 0 R 286 0 R 296 0 R 304 0 R 308 0 R 310 0 R 312 0 R 314 0 R 316 0 R 318 0 R 320 0 R 322 0 R 328 0 R 336 0 R 338 0 R 340 0 R 342 0 R 344 0 R 354 0 R 362 0 R ] /Contents 191 0 R >> endobj 191 0 obj << /Length 20356 >> stream 0.271 0.267 0.267 rg q 15.000 -1.891 577.500 778.891 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(We extended the age-structured SEIR \(susceptible, latent, infectious, recovered\) model of Medlock & Galvani )] TJ ET 0.267 0.267 0.267 rg BT 500.412 767.476 Td /F1 9.8 Tf [([12])] TJ ET 0.271 0.267 0.267 rg BT 516.675 767.476 Td /F1 9.8 Tf [( to include )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(two levels of risk for complications due to influenza infection. We parametrized this model using data from the 2009 H1N1 )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(influenza pandemic. We also extended the framework to incorporate staggered delivery of vaccine doses. We outline the )] TJ ET BT 26.250 731.762 Td /F1 9.8 Tf [(methods here; see Text S1 for more details.)] TJ ET BT 26.250 712.357 Td /F1 9.8 Tf [(We assumed that the mean latent period was 2 days )] TJ ET 0.267 0.267 0.267 rg BT 256.028 712.357 Td /F1 9.8 Tf [([14])] TJ ET BT 272.291 712.357 Td /F1 9.8 Tf [([15])] TJ ET 0.271 0.267 0.267 rg BT 288.554 712.357 Td /F1 9.8 Tf [( and that the mean infectious period was 7 days )] TJ ET 0.267 0.267 0.267 rg BT 497.750 712.357 Td /F1 9.8 Tf [([14])] TJ ET 0.271 0.267 0.267 rg BT 514.013 712.357 Td /F1 9.8 Tf [( . We also )] TJ ET BT 26.250 700.452 Td /F1 9.8 Tf [(assumed that people aged 50 and older had some residual immunity due to antigenic similarity of 2009 H1N1 with other H1N1 )] TJ ET BT 26.250 688.548 Td /F1 9.8 Tf [(viruses circulating in the past )] TJ ET 0.267 0.267 0.267 rg BT 154.131 688.548 Td /F1 9.8 Tf [([4])] TJ ET BT 164.973 688.548 Td /F1 9.8 Tf [([16])] TJ ET 0.271 0.267 0.267 rg BT 181.236 688.548 Td /F1 9.8 Tf [( . The contact matrix describing potential infectious contacts between individuals of different )] TJ ET BT 26.250 676.643 Td /F1 9.8 Tf [(ages was taken from survey data )] TJ ET 0.267 0.267 0.267 rg BT 172.022 676.643 Td /F1 9.8 Tf [([12])] TJ ET BT 188.285 676.643 Td /F1 9.8 Tf [([17])] TJ ET 0.271 0.267 0.267 rg BT 204.548 676.643 Td /F1 9.8 Tf [(, with the probability of infection given a sufficient contact being chosen so that the )] TJ ET BT 26.250 663.462 Td /F1 9.8 Tf [(basic reproductive number \()] TJ ET q 16.500 0 0 13.500 147.082 660.762 cm /I50 Do Q BT 163.582 663.462 Td /F1 9.8 Tf [(\) was )] TJ ET q 15.000 0 0 10.500 189.585 663.762 cm /I52 Do Q 0.267 0.267 0.267 rg BT 204.585 663.462 Td /F1 9.8 Tf [([18])] TJ ET 0.271 0.267 0.267 rg BT 220.848 663.462 Td /F1 9.8 Tf [(. We also considered )] TJ ET q 46.500 0 0 13.500 314.594 660.762 cm /I54 Do Q BT 361.094 663.462 Td /F1 9.8 Tf [(, )] TJ ET q 15.000 0 0 10.500 366.515 663.762 cm /I56 Do Q BT 381.515 663.462 Td /F1 9.8 Tf [( and )] TJ ET q 15.750 0 0 10.500 403.199 663.762 cm /I58 Do Q BT 418.949 663.462 Td /F1 9.8 Tf [( \(Text S1\).)] TJ ET BT 26.250 643.738 Td /F1 9.8 Tf [(The transmission model was parametrized with a mean of 22.5% of the population defined as at high risk for influenza )] TJ ET BT 26.250 631.833 Td /F1 9.8 Tf [(complications, due to other, preexisting medical conditions, with the proportion at high risk varying among age groups )] TJ ET 0.267 0.267 0.267 rg BT 534.557 631.833 Td /F1 9.8 Tf [([19])] TJ ET 0.271 0.267 0.267 rg BT 550.820 631.833 Td /F1 9.8 Tf [( . We )] TJ ET BT 26.250 619.929 Td /F1 9.8 Tf [(assumed that high-risk people had 9 times higher case mortality ratio and 3 times higher case hospitalization ratio, compared to )] TJ ET BT 26.250 608.024 Td /F1 9.8 Tf [(low-risk people )] TJ ET 0.267 0.267 0.267 rg BT 93.974 608.024 Td /F1 9.8 Tf [([20])] TJ ET 0.271 0.267 0.267 rg BT 110.237 608.024 Td /F1 9.8 Tf [( . For the age-dependent case mortality ratios and case hospitalization ratios, averaged over risk, we used )] TJ ET BT 26.250 596.119 Td /F1 9.8 Tf [(the ratios derived in a statistical analysis of deaths, hospitalizations, and survey-reported H1N1 infections from New York City )] TJ ET BT 26.250 584.214 Td /F1 9.8 Tf [(and Milwaukee )] TJ ET 0.267 0.267 0.267 rg BT 93.983 584.214 Td /F1 9.8 Tf [([13])] TJ ET 0.271 0.267 0.267 rg BT 110.246 584.214 Td /F1 9.8 Tf [( .)] TJ ET BT 26.250 547.612 Td /F4 12.0 Tf [(Supporting Material)] TJ ET 0.267 0.267 0.267 rg BT 26.250 527.658 Td /F1 9.8 Tf [(Text S1: Detailed Methods)] TJ ET 0.965 0.965 0.965 rg 26.250 315.832 555.000 201.945 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 517.777 m 581.250 517.777 l 581.250 517.027 l 26.250 517.027 l f 26.250 315.832 m 581.250 315.832 l 581.250 316.582 l 26.250 316.582 l f q 112.500 0 0 112.500 35.250 395.527 cm /I60 Do Q q 35.250 327.082 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 378.538 Td /F4 9.8 Tf [(Figure S1. Optimal vaccine allocation for different vaccine delivery schedules, different values of )] TJ ET q 16.500 0 0 13.500 486.080 376.027 cm /I62 Do Q BT 502.580 378.538 Td /F4 9.8 Tf [(, and different )] TJ ET BT 35.250 364.801 Td /F4 9.8 Tf [(objectives.)] TJ ET BT 85.648 364.801 Td /F1 9.8 Tf [( The delivery schedule 45M + 4 20M doses corresponds to 5 batches of vaccine delivery: 45M doses on 15 )] TJ ET BT 35.250 351.065 Td /F1 9.8 Tf [(October and 20M doses each of the following 4 weeks. The different shades of blue correspond to the optimal allocation of )] TJ ET BT 35.250 337.329 Td /F1 9.8 Tf [(the different delivery batches. The graphs for )] TJ ET q 47.250 0 0 13.500 231.430 334.818 cm /I64 Do Q BT 278.680 337.329 Td /F1 9.8 Tf [( and )] TJ ET q 15.000 0 0 10.500 300.364 337.818 cm /I66 Do Q BT 315.364 337.329 Td /F1 9.8 Tf [( are in the main text.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 133.859 555.000 174.473 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 308.332 m 581.250 308.332 l 581.250 307.582 l 26.250 307.582 l f 26.250 133.859 m 581.250 133.859 l 581.250 134.609 l 26.250 134.609 l f q 112.500 0 0 112.500 35.250 186.082 cm /I68 Do Q q 35.250 145.109 537.000 34.973 re W n 0.271 0.267 0.267 rg BT 35.250 169.093 Td /F4 9.8 Tf [(Figure S2. The impact on infections, deaths, and hospitalizations for different vaccine delivery schedules, different )] TJ ET BT 35.250 155.356 Td /F4 9.8 Tf [(values of )] TJ ET q 16.500 0 0 13.500 80.227 152.845 cm /I70 Do Q BT 96.727 155.356 Td /F4 9.8 Tf [(, and different objectives)] TJ ET BT 211.591 155.356 Td /F1 9.8 Tf [(. The graphs for )] TJ ET q 47.250 0 0 13.500 283.127 152.845 cm /I72 Do Q BT 330.377 155.356 Td /F1 9.8 Tf [( are in the main)] TJ ET Q 0.965 0.965 0.965 rg 26.250 -1.891 555.000 128.250 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 126.359 m 581.250 126.359 l 581.250 125.609 l 26.250 125.609 l f q 112.500 0 0 112.500 35.250 4.109 cm /I74 Do Q q 35.250 -1.891 537.000 0.000 re W n Q Q q 15.000 -1.891 577.500 778.891 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(We extended the age-structured SEIR \(susceptible, latent, infectious, recovered\) model of Medlock & Galvani )] TJ ET 0.267 0.267 0.267 rg BT 500.412 767.476 Td /F1 9.8 Tf [([12])] TJ ET 0.271 0.267 0.267 rg BT 516.675 767.476 Td /F1 9.8 Tf [( to include )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(two levels of risk for complications due to influenza infection. We parametrized this model using data from the 2009 H1N1 )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(influenza pandemic. We also extended the framework to incorporate staggered delivery of vaccine doses. We outline the )] TJ ET BT 26.250 731.762 Td /F1 9.8 Tf [(methods here; see Text S1 for more details.)] TJ ET BT 26.250 712.357 Td /F1 9.8 Tf [(We assumed that the mean latent period was 2 days )] TJ ET 0.267 0.267 0.267 rg BT 256.028 712.357 Td /F1 9.8 Tf [([14])] TJ ET BT 272.291 712.357 Td /F1 9.8 Tf [([15])] TJ ET 0.271 0.267 0.267 rg BT 288.554 712.357 Td /F1 9.8 Tf [( and that the mean infectious period was 7 days )] TJ ET 0.267 0.267 0.267 rg BT 497.750 712.357 Td /F1 9.8 Tf [([14])] TJ ET 0.271 0.267 0.267 rg BT 514.013 712.357 Td /F1 9.8 Tf [( . We also )] TJ ET BT 26.250 700.452 Td /F1 9.8 Tf [(assumed that people aged 50 and older had some residual immunity due to antigenic similarity of 2009 H1N1 with other H1N1 )] TJ ET BT 26.250 688.548 Td /F1 9.8 Tf [(viruses circulating in the past )] TJ ET 0.267 0.267 0.267 rg BT 154.131 688.548 Td /F1 9.8 Tf [([4])] TJ ET BT 164.973 688.548 Td /F1 9.8 Tf [([16])] TJ ET 0.271 0.267 0.267 rg BT 181.236 688.548 Td /F1 9.8 Tf [( . The contact matrix describing potential infectious contacts between individuals of different )] TJ ET BT 26.250 676.643 Td /F1 9.8 Tf [(ages was taken from survey data )] TJ ET 0.267 0.267 0.267 rg BT 172.022 676.643 Td /F1 9.8 Tf [([12])] TJ ET BT 188.285 676.643 Td /F1 9.8 Tf [([17])] TJ ET 0.271 0.267 0.267 rg BT 204.548 676.643 Td /F1 9.8 Tf [(, with the probability of infection given a sufficient contact being chosen so that the )] TJ ET BT 26.250 663.462 Td /F1 9.8 Tf [(basic reproductive number \()] TJ ET q 16.500 0 0 13.500 147.082 660.762 cm /I76 Do Q BT 163.582 663.462 Td /F1 9.8 Tf [(\) was )] TJ ET q 15.000 0 0 10.500 189.585 663.762 cm /I78 Do Q 0.267 0.267 0.267 rg BT 204.585 663.462 Td /F1 9.8 Tf [([18])] TJ ET 0.271 0.267 0.267 rg BT 220.848 663.462 Td /F1 9.8 Tf [(. We also considered )] TJ ET q 46.500 0 0 13.500 314.594 660.762 cm /I80 Do Q BT 361.094 663.462 Td /F1 9.8 Tf [(, )] TJ ET q 15.000 0 0 10.500 366.515 663.762 cm /I82 Do Q BT 381.515 663.462 Td /F1 9.8 Tf [( and )] TJ ET q 15.750 0 0 10.500 403.199 663.762 cm /I84 Do Q BT 418.949 663.462 Td /F1 9.8 Tf [( \(Text S1\).)] TJ ET BT 26.250 643.738 Td /F1 9.8 Tf [(The transmission model was parametrized with a mean of 22.5% of the population defined as at high risk for influenza )] TJ ET BT 26.250 631.833 Td /F1 9.8 Tf [(complications, due to other, preexisting medical conditions, with the proportion at high risk varying among age groups )] TJ ET 0.267 0.267 0.267 rg BT 534.557 631.833 Td /F1 9.8 Tf [([19])] TJ ET 0.271 0.267 0.267 rg BT 550.820 631.833 Td /F1 9.8 Tf [( . We )] TJ ET BT 26.250 619.929 Td /F1 9.8 Tf [(assumed that high-risk people had 9 times higher case mortality ratio and 3 times higher case hospitalization ratio, compared to )] TJ ET BT 26.250 608.024 Td /F1 9.8 Tf [(low-risk people )] TJ ET 0.267 0.267 0.267 rg BT 93.974 608.024 Td /F1 9.8 Tf [([20])] TJ ET 0.271 0.267 0.267 rg BT 110.237 608.024 Td /F1 9.8 Tf [( . For the age-dependent case mortality ratios and case hospitalization ratios, averaged over risk, we used )] TJ ET BT 26.250 596.119 Td /F1 9.8 Tf [(the ratios derived in a statistical analysis of deaths, hospitalizations, and survey-reported H1N1 infections from New York City )] TJ ET BT 26.250 584.214 Td /F1 9.8 Tf [(and Milwaukee )] TJ ET 0.267 0.267 0.267 rg BT 93.983 584.214 Td /F1 9.8 Tf [([13])] TJ ET 0.271 0.267 0.267 rg BT 110.246 584.214 Td /F1 9.8 Tf [( .)] TJ ET BT 26.250 547.612 Td /F4 12.0 Tf [(Supporting Material)] TJ ET 0.267 0.267 0.267 rg BT 26.250 527.658 Td /F1 9.8 Tf [(Text S1: Detailed Methods)] TJ ET 0.965 0.965 0.965 rg 26.250 315.832 555.000 201.945 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 517.777 m 581.250 517.777 l 581.250 517.027 l 26.250 517.027 l f 26.250 315.832 m 581.250 315.832 l 581.250 316.582 l 26.250 316.582 l f q 112.500 0 0 112.500 35.250 395.527 cm /I86 Do Q q 35.250 327.082 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 378.538 Td /F4 9.8 Tf [(Figure S1. Optimal vaccine allocation for different vaccine delivery schedules, different values of )] TJ ET q 16.500 0 0 13.500 486.080 376.027 cm /I88 Do Q BT 502.580 378.538 Td /F4 9.8 Tf [(, and different )] TJ ET BT 35.250 364.801 Td /F4 9.8 Tf [(objectives.)] TJ ET BT 85.648 364.801 Td /F1 9.8 Tf [( The delivery schedule 45M + 4 20M doses corresponds to 5 batches of vaccine delivery: 45M doses on 15 )] TJ ET BT 35.250 351.065 Td /F1 9.8 Tf [(October and 20M doses each of the following 4 weeks. The different shades of blue correspond to the optimal allocation of )] TJ ET BT 35.250 337.329 Td /F1 9.8 Tf [(the different delivery batches. The graphs for )] TJ ET q 47.250 0 0 13.500 231.430 334.818 cm /I90 Do Q BT 278.680 337.329 Td /F1 9.8 Tf [( and )] TJ ET q 15.000 0 0 10.500 300.364 337.818 cm /I92 Do Q BT 315.364 337.329 Td /F1 9.8 Tf [( are in the main text.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 133.859 555.000 174.473 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 308.332 m 581.250 308.332 l 581.250 307.582 l 26.250 307.582 l f 26.250 133.859 m 581.250 133.859 l 581.250 134.609 l 26.250 134.609 l f q 112.500 0 0 112.500 35.250 186.082 cm /I94 Do Q q 35.250 145.109 537.000 34.973 re W n 0.271 0.267 0.267 rg BT 35.250 169.093 Td /F4 9.8 Tf [(Figure S2. The impact on infections, deaths, and hospitalizations for different vaccine delivery schedules, different )] TJ ET BT 35.250 155.356 Td /F4 9.8 Tf [(values of )] TJ ET q 16.500 0 0 13.500 80.227 152.845 cm /I96 Do Q BT 96.727 155.356 Td /F4 9.8 Tf [(, and different objectives)] TJ ET BT 211.591 155.356 Td /F1 9.8 Tf [(. The graphs for )] TJ ET q 47.250 0 0 13.500 283.127 152.845 cm /I98 Do Q BT 330.377 155.356 Td /F1 9.8 Tf [( are in the main)] TJ ET Q 0.965 0.965 0.965 rg 26.250 -1.891 555.000 128.250 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 126.359 m 581.250 126.359 l 581.250 125.609 l 26.250 125.609 l f q 112.500 0 0 112.500 35.250 4.109 cm /I100 Do Q q 35.250 -1.891 537.000 0.000 re W n Q Q q 15.000 -1.891 577.500 778.891 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(We extended the age-structured SEIR \(susceptible, latent, infectious, recovered\) model of Medlock & Galvani )] TJ ET 0.267 0.267 0.267 rg BT 500.412 767.476 Td /F1 9.8 Tf [([12])] TJ ET 0.271 0.267 0.267 rg BT 516.675 767.476 Td /F1 9.8 Tf [( to include )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(two levels of risk for complications due to influenza infection. We parametrized this model using data from the 2009 H1N1 )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(influenza pandemic. We also extended the framework to incorporate staggered delivery of vaccine doses. We outline the )] TJ ET BT 26.250 731.762 Td /F1 9.8 Tf [(methods here; see Text S1 for more details.)] TJ ET BT 26.250 712.357 Td /F1 9.8 Tf [(We assumed that the mean latent period was 2 days )] TJ ET 0.267 0.267 0.267 rg BT 256.028 712.357 Td /F1 9.8 Tf [([14])] TJ ET BT 272.291 712.357 Td /F1 9.8 Tf [([15])] TJ ET 0.271 0.267 0.267 rg BT 288.554 712.357 Td /F1 9.8 Tf [( and that the mean infectious period was 7 days )] TJ ET 0.267 0.267 0.267 rg BT 497.750 712.357 Td /F1 9.8 Tf [([14])] TJ ET 0.271 0.267 0.267 rg BT 514.013 712.357 Td /F1 9.8 Tf [( . We also )] TJ ET BT 26.250 700.452 Td /F1 9.8 Tf [(assumed that people aged 50 and older had some residual immunity due to antigenic similarity of 2009 H1N1 with other H1N1 )] TJ ET BT 26.250 688.548 Td /F1 9.8 Tf [(viruses circulating in the past )] TJ ET 0.267 0.267 0.267 rg BT 154.131 688.548 Td /F1 9.8 Tf [([4])] TJ ET BT 164.973 688.548 Td /F1 9.8 Tf [([16])] TJ ET 0.271 0.267 0.267 rg BT 181.236 688.548 Td /F1 9.8 Tf [( . The contact matrix describing potential infectious contacts between individuals of different )] TJ ET BT 26.250 676.643 Td /F1 9.8 Tf [(ages was taken from survey data )] TJ ET 0.267 0.267 0.267 rg BT 172.022 676.643 Td /F1 9.8 Tf [([12])] TJ ET BT 188.285 676.643 Td /F1 9.8 Tf [([17])] TJ ET 0.271 0.267 0.267 rg BT 204.548 676.643 Td /F1 9.8 Tf [(, with the probability of infection given a sufficient contact being chosen so that the )] TJ ET BT 26.250 663.462 Td /F1 9.8 Tf [(basic reproductive number \()] TJ ET q 16.500 0 0 13.500 147.082 660.762 cm /I102 Do Q BT 163.582 663.462 Td /F1 9.8 Tf [(\) was )] TJ ET q 15.000 0 0 10.500 189.585 663.762 cm /I104 Do Q 0.267 0.267 0.267 rg BT 204.585 663.462 Td /F1 9.8 Tf [([18])] TJ ET 0.271 0.267 0.267 rg BT 220.848 663.462 Td /F1 9.8 Tf [(. We also considered )] TJ ET q 46.500 0 0 13.500 314.594 660.762 cm /I106 Do Q BT 361.094 663.462 Td /F1 9.8 Tf [(, )] TJ ET q 15.000 0 0 10.500 366.515 663.762 cm /I108 Do Q BT 381.515 663.462 Td /F1 9.8 Tf [( and )] TJ ET q 15.750 0 0 10.500 403.199 663.762 cm /I110 Do Q BT 418.949 663.462 Td /F1 9.8 Tf [( \(Text S1\).)] TJ ET BT 26.250 643.738 Td /F1 9.8 Tf [(The transmission model was parametrized with a mean of 22.5% of the population defined as at high risk for influenza )] TJ ET BT 26.250 631.833 Td /F1 9.8 Tf [(complications, due to other, preexisting medical conditions, with the proportion at high risk varying among age groups )] TJ ET 0.267 0.267 0.267 rg BT 534.557 631.833 Td /F1 9.8 Tf [([19])] TJ ET 0.271 0.267 0.267 rg BT 550.820 631.833 Td /F1 9.8 Tf [( . We )] TJ ET BT 26.250 619.929 Td /F1 9.8 Tf [(assumed that high-risk people had 9 times higher case mortality ratio and 3 times higher case hospitalization ratio, compared to )] TJ ET BT 26.250 608.024 Td /F1 9.8 Tf [(low-risk people )] TJ ET 0.267 0.267 0.267 rg BT 93.974 608.024 Td /F1 9.8 Tf [([20])] TJ ET 0.271 0.267 0.267 rg BT 110.237 608.024 Td /F1 9.8 Tf [( . For the age-dependent case mortality ratios and case hospitalization ratios, averaged over risk, we used )] TJ ET BT 26.250 596.119 Td /F1 9.8 Tf [(the ratios derived in a statistical analysis of deaths, hospitalizations, and survey-reported H1N1 infections from New York City )] TJ ET BT 26.250 584.214 Td /F1 9.8 Tf [(and Milwaukee )] TJ ET 0.267 0.267 0.267 rg BT 93.983 584.214 Td /F1 9.8 Tf [([13])] TJ ET 0.271 0.267 0.267 rg BT 110.246 584.214 Td /F1 9.8 Tf [( .)] TJ ET BT 26.250 547.612 Td /F4 12.0 Tf [(Supporting Material)] TJ ET 0.267 0.267 0.267 rg BT 26.250 527.658 Td /F1 9.8 Tf [(Text S1: Detailed Methods)] TJ ET 0.965 0.965 0.965 rg 26.250 315.832 555.000 201.945 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 517.777 m 581.250 517.777 l 581.250 517.027 l 26.250 517.027 l f 26.250 315.832 m 581.250 315.832 l 581.250 316.582 l 26.250 316.582 l f q 112.500 0 0 112.500 35.250 395.527 cm /I112 Do Q q 35.250 327.082 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 378.538 Td /F4 9.8 Tf [(Figure S1. Optimal vaccine allocation for different vaccine delivery schedules, different values of )] TJ ET q 16.500 0 0 13.500 486.080 376.027 cm /I114 Do Q BT 502.580 378.538 Td /F4 9.8 Tf [(, and different )] TJ ET BT 35.250 364.801 Td /F4 9.8 Tf [(objectives.)] TJ ET BT 85.648 364.801 Td /F1 9.8 Tf [( The delivery schedule 45M + 4 20M doses corresponds to 5 batches of vaccine delivery: 45M doses on 15 )] TJ ET BT 35.250 351.065 Td /F1 9.8 Tf [(October and 20M doses each of the following 4 weeks. The different shades of blue correspond to the optimal allocation of )] TJ ET BT 35.250 337.329 Td /F1 9.8 Tf [(the different delivery batches. The graphs for )] TJ ET q 47.250 0 0 13.500 231.430 334.818 cm /I116 Do Q BT 278.680 337.329 Td /F1 9.8 Tf [( and )] TJ ET q 15.000 0 0 10.500 300.364 337.818 cm /I118 Do Q BT 315.364 337.329 Td /F1 9.8 Tf [( are in the main text.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 133.859 555.000 174.473 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 308.332 m 581.250 308.332 l 581.250 307.582 l 26.250 307.582 l f 26.250 133.859 m 581.250 133.859 l 581.250 134.609 l 26.250 134.609 l f q 112.500 0 0 112.500 35.250 186.082 cm /I120 Do Q q 35.250 145.109 537.000 34.973 re W n 0.271 0.267 0.267 rg BT 35.250 169.093 Td /F4 9.8 Tf [(Figure S2. The impact on infections, deaths, and hospitalizations for different vaccine delivery schedules, different )] TJ ET BT 35.250 155.356 Td /F4 9.8 Tf [(values of )] TJ ET q 16.500 0 0 13.500 80.227 152.845 cm /I122 Do Q BT 96.727 155.356 Td /F4 9.8 Tf [(, and different objectives)] TJ ET BT 211.591 155.356 Td /F1 9.8 Tf [(. The graphs for )] TJ ET q 47.250 0 0 13.500 283.127 152.845 cm /I124 Do Q BT 330.377 155.356 Td /F1 9.8 Tf [( are in the main)] TJ ET Q 0.965 0.965 0.965 rg 26.250 -1.891 555.000 128.250 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 126.359 m 581.250 126.359 l 581.250 125.609 l 26.250 125.609 l f q 112.500 0 0 112.500 35.250 4.109 cm /I126 Do Q q 35.250 -1.891 537.000 0.000 re W n Q Q q 112.500 0 0 112.500 35.250 395.527 cm /I128 Do Q q 112.500 0 0 112.500 35.250 186.082 cm /I130 Do Q q 112.500 0 0 112.500 35.250 4.109 cm /I132 Do Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(4)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Influenza)] TJ ET Q endstream endobj 192 0 obj << /Type /Annot /Subtype /Link /A 193 0 R /Border [0 0 0] /H /I /Rect [ 500.4120 766.5743 516.6750 776.4950 ] >> endobj 193 0 obj << /Type /Action >> endobj 194 0 obj << /Type /Annot /Subtype /Link /A 195 0 R /Border [0 0 0] /H /I /Rect [ 256.0283 711.4553 272.2912 721.3759 ] >> endobj 195 0 obj << /Type /Action >> endobj 196 0 obj << /Type /Annot /Subtype /Link /A 197 0 R /Border [0 0 0] /H /I /Rect [ 272.2912 711.4553 288.5542 721.3759 ] >> endobj 197 0 obj << /Type /Action >> endobj 198 0 obj << /Type /Annot /Subtype /Link /A 199 0 R /Border [0 0 0] /H /I /Rect [ 497.7503 711.4553 514.0133 721.3759 ] >> endobj 199 0 obj << /Type /Action >> endobj 200 0 obj << /Type /Annot /Subtype /Link /A 201 0 R /Border [0 0 0] /H /I /Rect [ 154.1310 687.6458 164.9730 697.5665 ] >> endobj 201 0 obj << /Type /Action >> endobj 202 0 obj << /Type /Annot /Subtype /Link /A 203 0 R /Border [0 0 0] /H /I /Rect [ 164.9730 687.6458 181.2360 697.5665 ] >> endobj 203 0 obj << /Type /Action >> endobj 204 0 obj << /Type /Annot /Subtype /Link /A 205 0 R /Border [0 0 0] /H /I /Rect [ 172.0223 675.7411 188.2853 685.6617 ] >> endobj 205 0 obj << /Type /Action >> endobj 206 0 obj << /Type /Annot /Subtype /Link /A 207 0 R /Border [0 0 0] /H /I /Rect [ 188.2853 675.7411 204.5483 685.6617 ] >> endobj 207 0 obj << /Type /Action >> endobj 208 0 obj << /Type /XObject /Subtype /Image /Width 22 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 22 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 226>> stream c`0b@|XMb> YsE&qEX\"s.HʝX"<猞Jц TQ{zx@x*q\P;d!'b ps:@eÆ(@r) uS@ ]}CCXx MԹ6< 10AY@@lŴ&X \ jAfXv@CXiJLU([.C endstream endobj 209 0 obj << /Type /XObject /Subtype /Image /Width 22 /Height 18 /SMask 208 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 22 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 18>> stream 8c`` endstream endobj 210 0 obj << /Type /XObject /Subtype /Image /Width 20 /Height 14 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 20 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 135>> stream c`@,L %Yp1DX¹0}!&`TB0*x&&0L+3P3aU tM;vJyGlmNh `9;@<c-/ endstream endobj 211 0 obj << /Type /XObject /Subtype /Image /Width 20 /Height 14 /SMask 210 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 20 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 17>> stream (c``PV endstream endobj 212 0 obj << /Type /Annot /Subtype /Link /A 213 0 R /Border [0 0 0] /H /I /Rect [ 204.5850 662.5601 220.8480 672.4807 ] >> endobj 213 0 obj << /Type /Action >> endobj 214 0 obj << /Type /XObject /Subtype /Image /Width 62 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 62 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 399>> stream 8c`0b ul;7c B*fm &Aɚ3Fx5gMٴƎ c`rH f: Dy\( o &sSsm BǷ\8$@9܉ljG39RUwAFg*~:DP%b& MU, J\9"DY8 4=t$; Q>Ӡ~sHn9%$S pD@( JADzǀQ־$ HYzy10DaCL CB;вYu$I 'TKClŴ&v}JY\l,5t%g:`E+M*"[7JH. endstream endobj 215 0 obj << /Type /XObject /Subtype /Image /Width 62 /Height 18 /SMask 214 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 62 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Oi  & endstream endobj 216 0 obj << /Type /XObject /Subtype /Image /Width 20 /Height 14 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 20 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 147>> stream c````ba6ؔev li`+1.8D'`V@aH[8l!@Y'U`,$37-fj #s`+00(qCτz>8À An6)Q endstream endobj 217 0 obj << /Type /XObject /Subtype /Image /Width 20 /Height 14 /SMask 216 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 20 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 17>> stream (c``PV endstream endobj 218 0 obj << /Type /XObject /Subtype /Image /Width 21 /Height 14 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 21 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 211>> stream c```a&]V3kTjEǜ. BXÊ*= gZ)D>6SZ HSc`PPݱ$z! bI121 QE:P킘 et(XtHP h\XChe U-[)LϾ 5@M2 SZ1@B; endstream endobj 219 0 obj << /Type /XObject /Subtype /Image /Width 21 /Height 14 /SMask 218 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 21 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 17>> stream (c``  endstream endobj 220 0 obj << /Type /Annot /Subtype /Link /A 221 0 R /Border [0 0 0] /H /I /Rect [ 534.5565 630.9316 550.8195 640.8522 ] >> endobj 221 0 obj << /Type /Action >> endobj 222 0 obj << /Type /Annot /Subtype /Link /A 223 0 R /Border [0 0 0] /H /I /Rect [ 93.9735 607.1221 110.2365 617.0427 ] >> endobj 223 0 obj << /Type /Action >> endobj 224 0 obj << /Type /Annot /Subtype /Link /A 225 0 R /Border [0 0 0] /H /I /Rect [ 93.9832 583.3126 110.2463 593.2332 ] >> endobj 225 0 obj << /Type /Action >> endobj 226 0 obj << /Type /Annot /Subtype /Link /A 227 0 R /Border [0 0 0] /H /I /Rect [ 26.2500 526.7558 141.1343 536.6764 ] >> endobj 227 0 obj << /Type /Action /S /URI /URI (http://www.math.clemson.edu/~medlock/other/SwineFluTextS1.pdf) >> endobj 228 0 obj << /Type /Annot /Subtype /Link /A 229 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 395.5267 147.7500 508.0267 ] >> endobj 229 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coverage1220.png) >> endobj 230 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 231 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 230 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16064>> stream xitǕ&zVT Ka'P"(bkYg5ȶ4HOg'α4>}FjҲ([<iv$})(ԚGȈDRyo 3qͥ2cB۴4afs{{پ};9T__fggvyᬬ,544J$DffffŊ---p… yyy###͛7o.,,U2 B'&&gff/LLLfdd*k׮n5::vfKnݚ b)--miiQcxhQQQGGG~~~~~~{{{(zzzJJJl6[8V$c nAq6(pCHL̢ Rq 2Jsss9XIjq.=V9(r5䦦& ggg׮] Na`@ą"Njnn@0T@ojeAVkCCC0裏^oqqH^^4S m5,S=(B#x)pڒS(S/((w,uk]?T9N7; R3P(J[f  pPz>]drzzԛfl2;k9((T… .\ 5/" nD*x_5@`iwi$`5"KJ=z,'[(f߻=R1PvLL&9qÂ-8nsiCq@ kK33]HiQ[k34QhkgK&cM088x…Cq^^lϩ*9$ Kh&F%RJ,&٦PRY(NUN+fwap=ݡa1XgfgfgDڗT% B#:Bx0]wߛ {l&7D$ݻER(rϋjVQ 1N:VsFVFGG$ƸOTUZ')Z*O JB!$%h ͢Vqi'Iː mB@ @*ڸqc~~>ݴiS<okkۼysFFBhʕŢp6bЖE^2:OK@dD1 >T_At?33WO@8'Ճˆa[pw\%H<'E"/4^Cẓr%)t8uuuԈ`bbdžVCa0 ysC/Fi N@qie\$  VqnnnUUUyyv$;/< 8"{P$(A1u'U\6D› Α⬊ *RU :ڎ\@WFt\"I"H$fggl6geeqù/[v; ^3([*(ȍ4!&''].W<}Gx?hw~[>-[ƙH" UUUy(;\oa6uX'|˗o 쥣/pR${D\|X$BraBT@f,_|xxx``@WNE2c`"hk;w&=nlCZh hg[RIB#BpmP$헆[VRjhٸ56@ D۫vrX&zDž="BZV1-SX`٣vi%dVUUXm/H#f^n9#H€A0zt X@.JCC/j* "/Uۄ B}}}֎D k0NY(E;%jQYLjAyd`r{0~! I bǧGiF@o ,CQƀzG%{Hd9:9(FT5立_~W_}:gW=Ur:lp3UZyoP!x  %&Xc!{ 4k6P4-ٔJvŋ$ӧ2ve̖X6ú(A Ccc2ἐ#`v0ںuk<}GFFFFF*** C~Y#ftJvȎhevjl "mVZE+**b`HR&k#MũT;ZC V+W2,A)"!seÎp .x%]j3؄P( Q,UTB9Q=SHLߪ ` .ͤotO^%q'=4 Z`zz`bbBocvGYAi-3̓9z(Ai*ԬrL} '9G*1ke8Ap>Q`/e [D"mggg{DbCYג"2g۲%WKjzPTdB% Ht@ MvW@QK~lmQڳiy`!"r B&/g(0HʼneG@HF:==rJT|b6[1^_B<%o޼`l~pzK}K 914PG`] !7̈~CCC;v8rMaFYIu'S}߿%]jyS+i7W:RJ^z<|0%hŹeE ԅ Hԅʂ1㥥˗/':u5k۷nݺaA믿=8UUd鱍#b'mJ1Ƅ Bloo@@Q/u&IV8. >fF{.[ !TXXINF*=ؑRDJJv=P+^&PdlmmrssP E H'h#E%X,ٹaصkLJŋ-6}BA ق2wT,% 9;e.%~z!K.YVŽ ;dbN-4<IHXąh~2Ldi<`hBp40W$CCE>hD>ܒT,zK5Aў m@Y|9`5S1 I ڱ^D+鈅 t t`׹l֐TD>M(n-iŒE J݃V&.tS Y6i=!\F|P#o8ױ}qݠģ>J 0,QTBX]Ε)}N+*B\p8mDjO*4eW&GA_5N a.)Ggg&S)4bF*F;ލ}2_% @db?l~衇^w|f/NV_-By^p?>iQJ ={ 7{wXg4rR@P0( cv,;r}[oH$D?NJN_J@$YXx [X8_AQ \?uıX'|~Y6K&Pl6]t)sfffARO 7ooll{ꩧjkkkFF85Dr9Q"` E)AnB@O<^Ch4nݺӧOb1ߟL&}dZuuuuuuk׮ep\錌_|qd$d2sssɋY<OQQdF7|30zEZk׮u\b@`vv#J*2yA F=T#9s9'| }e˖Z__ӳfJ#77Y,^z̤Ǝl>oϞ=7|( 7@M$//djjE?''ü3w}wppp.B 9~zӦM"Lin RlJO.%e* %v)ArT$8 ¬O$֭D"1)n{oJVkNNn?tЎ;XolXVZUQQTWW9s>B D2cY]]z~bzv;Ձۊɗ.KP~DL2yXrꫛ6mڶmB`-ql&s,\?w}a&G666?%o4.4HfY -HU5$AB:znp7J"P<>۸q#[x```ӦM.8((bE4:JjJn[ڊ%(PIʜ?{˗6nhXXJ ,1T`ڠrQ04 J@ np7o[~gffbZbqR8-mEAל\*D@Ra46ƸbI 5r7bыF, J.[=dЅ1(TEAI3_HsS-Kk+fPd}2w^ #^b+ LtN, HrR4DM8QH MiM:PTkE7O>$;"OzH?nǛTU;nnw{{n)-- pȑ#+WV5;l%g,T2lkkSe||<++?N$7nlkkX,Pnbbbٲe]]]W|˖-kjjp{{)((PӑHdٲedwsSN)2;;U\\1޿KK yorr;[m۶9Ϊʙ@ PSS366j*r#$.;ZZ$;sR.Dfttr vwwY%~rÆ n{vv6 R꒒rQZZZQQחg6KKKv{QQQ" WU*رd2`0srrJKKڵkE>&cbhlD˞\q. %=9bXGGǪU@柤611A~a1M(RJ|f9;;{bb"Lr#c, b9Kڻ}N( =|fJKKY1i\ӤBsCCիf&iQ?"sLtp)UU5Htww;vĬqI#8߮G8am(CO BBqudL@q!ɣ@ 33sݩTm&MS9' ކa+fzrqAzB 3Mɣ| i=D=ֈ2R(In#(qW fuNKP&i'>m.48@iCQU`/ %-B3܆KևԠ! Ƕ⚋]j^PWj [ܠbq荋J$h E%]V,EGFϤL P-Eez3|cKAX@J:v .ȆBP*rn۠3n5t$" t%|V)[o%pH(۩8GPoM@qJ)!HJO nA=ztddr}[=Or%u_&Iuղe8M(7JC/PW%BR(IYzġc27FA8p`߾},2 m98x?Qvz{EK%HQwʕA[.pޕ-ܪ( Nu'%$2R@ /*f:c % l@VVփ>H˗;N|Vj69w=UQs6ݦɮA=(iq61}eK.wqΝ;\ee%Ƙ~@qz4EGX9+#$Rjb@$Mk[eWUUUWW-a})۫tX/&@K$bt:_z&P\B'Fhc( +9ڼcಞ$`WWAz/%]( }Q(|`cغu[,f#aTQ m-,Ti/,6{1sZjzfnW_RBӂ@}}}mmʕ+I3]z-~W2I-qMf˻v;G1gDž ܬ0| q8,]`JKnzYl[lBP_3όqc?z!H_nb z,;ήO ]7jaXٱ3 (>%xӗnU$=c5"APq64 ~'@TÍn=QqgmM\ЗHi9yCg'TU{׽bF ʊ {نՋdT,vݗΉ "7n%w[P$I4mZմD 6mR5hzZay:SCȑ#C\ax]E/sc4l\hue,#(t4HX P©=j900I/[ ~뛗B-eVM` r Ɣ%566߯t u^*ACl4}as IU3LN5iI[dPdG16,Aػw/{j ;j?g`;|V'R RpM*1 "Ƃ`yy99<44L&< ojgR+Fӿ}z 2싈/_btzXEEEEE%.Ao@+qY΋TUM ִb钅P`crx<9/i /קxJ( [I6EyK2#qs`xn#vPuD_e" R8I'- ̂29RXv-͛nl2tyjJyٛ4B6wn1$lj-j ОTpK ݭ[R/Xڌt^mAJTqN7c@֘5ٶ`-[vĉR:i أ(/Rc) H)C"@ pbp6/kq86>>(J4#nHvJ)XBvʕ+֭4F\$@6SUA+UV{m>@*i< 5|Ēr`JFGy [ul B^ۻ(7\S+& K hpeY"D?cld\,d;9Rq dR?_g,a;z4!&&&N>MmlLo">/l 1xY(ͪRT**UsM946DQ333lC!iAc*ivjN`{k6l@~*:wE A;u/%6a4 _j3O?)B ʛH: ,0"Otj)06't999X^zu}}}hܠ Su1l/'ȑ;cXFPku92%\4/Yxq6_x:qvv1HI31-#}}AvNIBA8Muي1% Ƹ!++)cl2>裂0sZ_&eSs޾p\,I=!*՟nJ 4d+ӂjkkF---}R7`[p% `v 9}r 5QZD,A fsUUƘ!Z/`DBEk?#f%EXGGŋ:ttw<˵{(sp|,OtAnF#<(Ƹ`.7żfOO5 طs3^3K^16-/Fin23233l6- 5B^" uu֤azz&3+v'1*|#.EF>naæYX-[YA | e7CJ`IB Rr7' >;כ„p'ΐ\e `R.\:fP:j ^glT(0,JvjLf=Z)%d]8I<&sX;wu@eeId/B:AM\"a޵'mBȧfg{q:;4.s B.H;RN1Bu FJ6?W_v(ɍ!ݺT*(qC @T*B&)JjRUcXMA  q3q2TU@PA;NT*J$b9V5+Jݶw woϑ }TxfsS$OY  # _|E}W^̬y7bC9q05f]Y\nwn^ѣgQ7̢VJŎ"'d2ÓLDr,38&q0LJqqզMg\vN"!Chn~i7Nd7"3=SΛLYtLB ʲJ<.d**){'H7#(OㅅPfm޼mjQ R) ѿ_,IR,RGpS/D^-W0SHÇ^Ť.\p8߹%EQ~L"xNQիK"իZ__GG!d[8" [(AzTR|agnǏ;NMՙL&EQ@kf67lؠ(Jkk+f=z4//O>!9lmm}ggIEQ>cǎ=zU^GI׉ &IX(T*Eן cQO<`& $@ c2"K>00P__O?Ib E?x6A5i&bk!''!T\\_[[L&ɤjn!dZx>cL+7c9>p@D I oK _&GF$###''~``_W{淪r\+V{>Я~;vѬtovII 744`~_cWQI)..X,g޽+V :9:=♙JD& =UR i^TTB.6N:11nݺ˗/6ʉQo޼9Jf19"#G[5Lk֬Q%Mf j! 'l BHQUU].ׁ;[ !S`E"~zGIQ% =zʕ+O>ba;tAEBs ;P۔^,nAlGTUEtM qC5'U|ԩ 6TTTqG'I:XL3'1nii)++#B4ހIDt㣏>b r)U\J<$BP e-rVvtt466^xq֭_(,2gCҙ&x PTv x Y̒L]HkhBUV!?666\[DGM{aGz*燢ŀ '(C5T2L;w.??=$rYk=J 8KB4K0 Xyĸ8KCXtS2ߦi 6s հ(k+߄7-ZaG?.&DWRC:T*w ^h4kc$' ڪWlPhHSk܄qˑu}GѨ_y]wbx vС{QG-((hjjZr=oQ322;v嬬,|-[/}K͛CPQQQ<O&7nϟߺuk4=wܶm۪~޽u__/v<>{7^*J(,, ^>---ձX쩧я~dTU|W~oo/Z-GMRDmdv@EEE 7ouɤ9z맧[ZZv5<}z֭7thvv6?I "mW 'k?ofgg;;;nݚH$B>pg+;~ٳffa].W^^lVV֡CjkkϞ=KVlN$͢###^78NKJJ,KaaÇs̴477~'@kn! FGG;;;W^]TT B𞞞@ STaa}jjj󳲲L&/--D"DB!Dl6۶mΜ9cZ#H 4L&|n9r[ou\ҥf4'qNj ``zĤ#nFeE!_zPٞLNNr$hmmMR'N;UUJ&\[N:PUujj!TQQz322, qJ"yիdUUmnn^rbٿ5kl{0W|nz뮿~lllϞ=wy|^onnc~444\z&''`rrf鮮ڶ>͖K"]fM<Vĉ 1###˖-%'if@XckleQzjoh>P^0L?~}{oh4:44aÆ+V[vr{@`H>nnn@p`8zɢ/ZҒ'Ntwwu]nXprrrˉ[)lrJKKvu{_rll%X,2>(777 8pŋ^7+++:th .˱Xc峳lUUU###ƋֳD"HVcB(LPXX855u7:NR\\yfL盙q\{MNN~zf3F))) Gپ}{fff$!9^~fb}}}Ddee}zMU57ń`0z[nm/++kΝp8 n;8믿>###777??… v"O(eggoذᮻjnn^jU* B]w]~~j-,,TUu4p"ABE8r^3Yn[vMSx}4ؓ'O*$&iŊMMMf9##EFtR0Z Dn7664IofRe&H#vOOO?~D_l6^;vlΝh> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 226>> stream c`0b@|XMb> YsE&qEX\"s.HʝX"<猞Jц TQ{zx@x*q\P;d!'b ps:@eÆ(@r) uS@ ]}CCXx MԹ6< 10AY@@lŴ&X \ jAfXv@CXiJLU([.C endstream endobj 233 0 obj << /Type /XObject /Subtype /Image /Width 22 /Height 18 /SMask 232 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 22 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 18>> stream 8c`` endstream endobj 234 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 391>> stream 8c`0b p@(mftt,[BH d>(k> Ys) 'S0lQJgbhCTƹ6w!~$,`sI H_s3z**E*P-@ 6m NPLTUHy@bR$-cٯqHq"f]0VA\=t@ǎaC!l)++;ה>(!m9%$SŒ)`@(4,@sIcB׀T@I?KO?&s3lxvbaBZ609ZK0```/SX) D?GV$1!_Ҕ"\ =" endstream endobj 235 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /SMask 234 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om_x \ endstream endobj 236 0 obj << /Type /XObject /Subtype /Image /Width 20 /Height 14 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 20 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 147>> stream c````ba6ؔev li`+1.8D'`V@aH[8l!@Y'U`,$37-fj #s`+00(qCτz>8À An6)Q endstream endobj 237 0 obj << /Type /XObject /Subtype /Image /Width 20 /Height 14 /SMask 236 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 20 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 17>> stream (c``PV endstream endobj 238 0 obj << /Type /Annot /Subtype /Link /A 239 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 186.0817 147.7500 298.5817 ] >> endobj 239 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/impact121720.png) >> endobj 240 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 241 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 240 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16363>> stream xͽyx[y/@b% ($.Ͳ؎Ik[7MK$wI{طu$Mk77vȵ,#[,ɲd-%j ; A$sh08`o~;3gE1L(W_bT*Ol{{/3Ϝ8q//Ye2PJ"Kngff^|ŏ>!$K/XRR}>PA~ҔbT( +[ O"wd8FO3H[n˖-T48^ Es㉌(Jh4F/(ό!˂d*R}蒘yAxLf HbX,>t yRm#n1 …h<W*^/h``@P(T^^>==ͬ;GtR.\쬭ݱcQ1(p Sx"#P-uLԈN@TNsssD xAłA___<yy"bV@+++:N& ⁸V^xF'HDx 'OXP(Izj()aJ`5(DnKU!3ǔ{xqF?Ѻ2A b%|y;n{<ֆn[,f+Z6ٳgVk^^D]jLLpc%O@)@P_hM$;ҵL^BиmAuj~rss{{{?D"q'N~hTEFsPLS B)Ѝ .LLLeͻZE֖\.1Ln{vv9N5%:x:({MMMOO( EԂY\Ӧ"e1ΘLi@Y 3"꺺ZB!B@ N=2E)ATVVFQP`L]D#ӑ, CC vuuMNNb1zUUU^`0+yG@.kfff֭-p&KYxH" qC"ݥ TP(^B@j޸qcjj`0H$JKK4/041H8q… ۷oyXEŲj0xG&Jjl6FFqddv=/|*ܤȻ<%Jwwwvv6QК̢6MӍO*C!ugjnݺD"jV*՝:("!: (dee};ߡd i+^EFQ`0ZO~_755766"U˄<lFG*DQb/^zN*JF.䵞JklE@L磳@1kfHYBܜfZ066pAAA__o "ȕ+WVWWyl4eB@VL f T(L&4RA8 NJ[;Z,J PSS311 T*鬨ti?NfWSFJtP*ëOd!0 !5"K /))67Ёh'J>#jVԧ> -80"ϊP*"~GGR/.Stqnnn<ymۼ^/iTޱR)VLdE"o,/dhkB>'??fݺuɉL.H"mmm=lFNwYI*'wKYuYV4+)FE[K<88S@0lll4.ڙ_ X,>mذU2NA'cI;KKKodeef֎9"ԂIC)p*(*NLLeNk׮:=@Z1OビF!LIP27\&)//OںgbYj!JzRvv~x<܌,֭[8 =dyZxp%CLp'2])(i(^-<(] I=0dggl6ڂ9NEd<+^ U(A(Bexm3#ScS|@ drݫ)!: &y^G 꼕҉X,Ah0 ^WՒ꛾oVUT$KkpppttјTLvJl000099i٪%LrI%.W@(Zn]p8Pj!BBёsv`4_yXn$anV8/^z [m6.]EœqpY89q" F-v:7nȔɓ'].ŋ}>_]]]{{;zn?)X@..=}jD"%QL.r:z?y b,5ϟjllܿ8[%AxBTaEKO"dQ$.W@\#e8;x91칹MMMUUUjvvggg{챕Tr'(4HIʆ\2LPY@TjTCBd;~Jg%9p' "m BDQ|EQt999j-3G kfH F5rD"A!p &%dV*CO {dwP *?R "W-2 GSRi~PkہyI1CCCO<]2faMJUUUhݺu<ώ;B#Lt<B999`0+++ Cj䐠z~Bs4P.bwwrIIZ^n=@0hIf%>[4=x^7 CCC]]]+++_b0,))хT"'&ot _x;v\p LM6ݼynPLYȰDQ|.]7˫Xn&dr{ٳҞe^_E@'(2 z^RMNNkylllppv\}{L/L\.zᇙrD'ɜX,OzӦMfٳUUUjZOx&@ݴizW{J_`;pFW> IS뙤zܩ{~ÁR*+++q 3/(:Bw5-R||A\rG 86(-D2z8YiLVAN≀'Df2yiҦn{Z EPk k0] ǗW2ɬLY On -L e^v:<+ ˉ4sss(}mm]ҁ'2g 3ZyL(jDx'&.^:S/2z\[Bí<ӧϟ? b߾}.RX,v̌j z^...|MP*GN'$dyȑ}k( xuCCCii)-K9ree~aCCC8]]]Dp@)5q-MVLH; &O %-/>ʓPRh:u۷oJ F7!GFFv霘0͈ 5XD8xcǎUVV~3׋pX֕"2liZ K_lF,d2[XXHH+0149|ҥK}Qaaa4Z7oFG]DÓ ϙbvY"XVJ%8zQSYYp8ɤtȗL}3 I*)(..h4 m8ڵK.Qp{{FM&11)Ҷ+ vt/ɜ|-" !k4ű`0XPP0??P(rrrм3qeltiL&U*Uqq1n }5 7l|ƍҖ.g][??ЬT+++PJ;VFQׇ7|z@>֍y ɤ@ӡZwo%o߾ |㍉c6z7+ӭ58XP B+}B Y +zfƦ?k]~LTʣuuuMAvt ("irxj3W"="]Qꔰ])+JZ]\\<99)&"u.*Ԇh*AS~!uΒH|h/pС]B%\SKxAD-aH":|WPk@Ԋq[ *8^2yE1";vlRc>㢢"RvKKK05`euc6io䓑Ēpc,xpǃ̡`08RdO>xmD"͎7exd#2H_?u,HUqqqIIDuu:K$Y4.(FQ֭ 6x  Eii)JBq^+![8ПEAؿ_ #۷oݎf{8CA41h kyyyÆ XgӦMsss T@џ5뺾:o ~ ʏtxއV^{mF -yS0t(C޽"k׮]ȫl: 菘%z 2 %ZQ4$@1DS@iiiNNSO=e'''ʘF IATg  2jdddzzzrr1˛a(#:v]i~~>Z"gsuDbΝh_F'𠚛r|c}>={z{{Z,!]tM ϟX,Ғm=WÇ-5}Ν;^f^RZdX)LNN5z-vrr:/]BFaB>UII477BKwݼS `+|6M]__뇆x≪+WTUU1;aQ'\YYAqhFRQt TTEp)G"tҥFbGTG#_$cg:DNlEuu+WhPf硩AJʋ<+gtG pୈX,VVV&Gϸ%PP+rwcЬT۶mۼy3zM4r$ نV1^*]M3H7 x\ZeI`H%{cju8zebk0\%ʮ nXCC˙}\t: #)e4##]GI?4,w2A˜߿]]lZ6LSSSib#(q`}~ÇH$C" v-x}Z{&''wg4#k.O³[1J#O<ݭ맦~iT"ju;6KPTCbcTLNNƐIp F,V '%c(G%9r9a@gR<~z:fEzqp:[y)feRCiV`tK_khh}vGGGmm-ԉk%-,ek(JlRqp^1[22sbƩ TWWzvrX]#㇏OX`f4ֺQ_yB1kpwy.=r,dspS7# BjM~ǭ]] # ->hlƒ1r|rd܅CdV޻2Sd>1*݌XYdaRۆIOB!X;͞^Y2X`/QY+%~Al d͋\+,jE9 p@";311122gϞ[nY,VPR{04͍hkN >=#Q_yZ}ƍ۷Y᳒3WRo~V=O$q:UUUCCC wTD9 uuı~_:W (P/vXR-[0t8.\xG6nxsO@Q ޼yʜus7dƊ IJOOh2xСCZv|||rrrǎh4www}P$ z4*4#` *FýO𶶶(&IÅ֭vD2"=o.2K إ 1Etvv ~AAA ) b͌vjd@OddK?(CfAG~P&>FIx74@ 0p'`O<>}CWw J;wq *a̎Bt KHaE*1c'0>>~ajzzzddgffҒ!hHT`?Љy1!U]_~vZ#G]2*-v$?)9W3LD"q5j4#bD"Drss'&&t`oýu;9cȚ0Vv1|n4(RDH&F= ۷O|eHDբLɐ',--+TJ2 .!Ytbd\x,7e+sPD2YK̻<t֎T~Wh8li:#pڵk hp8F#6  sϕwttl߾=?S<  X,C(3<#3W\lPHuuuutt^/}>1F'@> 2 `4/_<66 y7xC#3hR=XO %EyA1 eee/^v@LAt&);;н~R;==裏JoϞF^+liiA-%D"a2@ U7^]p-cf\|*nj6;´D3P#<crg 﫯1gGixI 뭷9RJRW*6 e/T K/)}[s`"]y O0R&>ɤ41sZݍA2S@#c~P{j8k-<%J@ ^5'Ҥ%EEAw$tbx anNIpLDpI ES3ҭxA^_SSs֡f=:::>>l0LSsE8-QKKKǛANѱ ƷC_W+[[Zy~@fez0͏<JH>ԩS555֭zNg6[ZZuL(\>4#7!7n8[ln^# GZmyJ۫("zŋkD}A65B KwJ+ _zci?>- JR( E]] Iųg'"T43(&N oJۿ = bc# rJ͟0J%H+3 BNN:y,TUͧ!Q.-_jy`+@rv5" y>H3qI$Dv>X/D0Hxފ c /lyyoVJȽS4q۶| j/| @peŲby2::*`GtrjSng|E2dwcYh(, { SD7VOw--- !;;/,uZqTd2qKZx&1ju;\>q3ītw6RƉ łcNY(A2Ph4*)8S{ȚڧxGXyf,t $˗/[H$RXX VqNСC. j{{{~'Nh׳慌BRF8L9sk_z.\mooqF~~͛ :%}Pnzf\G^~vs^ BOχB!xdd$L޺upppl6oذ5/?Gjܥq_]]NNU^?11!"$I}-8QQbن?tPYYن \.WNNNVVk^(g3PG=p;?SձX }u&J5%"Iho ~H$$w ǹ@ gg_~4khV`0 qUiI>JQ2Wv"UA/*C- 'Z.p8! j2)qb*'V1#T J_Zwf1B@k>,[&=Sz!P%F. q49wK&Cܥt^ĘHP5JԤjm[R!RRBLrTvI΅www H[/RV\-TDQڴiht\y!P|IǘAҥK6M+0I$1CRL&֭[d2 UUUIjX2:2N?}tvvӧQ|ii)`g\1 )Μ9nZKJJ:::^ ~?;` ee&J-}Jv:thpp0;;gOS,..r:ډD"''Z[!HqVD򴆑3<Jg833˝N\NNKR1ƨWsRJFV8`٘_$BD6:رc z8?H Qu:$xm6 և~~$FS1R 딭HIti˘_saJK)#ߴ4h"L0(G*SfdcQS4"K8ò)cFίfr$"(Ը<>r{+pjH/;/䮌Ӯ,q0a,{'qΈ}*VbF&. b&a c!fh y,=B22E#ġ St67`͋~?c}9R/ (n'ޑ!mV`h ˟Dbtկ~e0v޽sN/ 07b%ɃFAS7~"˧iCvv6nRv&Eb`]BWWWJ%&TEYbdx)E R$H$"QńBYz6K&<'/T· EA ->+R G6뫭UTя~TVVh$ᴘ `g;w߶lvud2T*ZPUZDM"?}>,jllyyyEW@ī'0HrJII :sέ_'?IGGL$K.mٲۑH Joqԩi #1A>ݻwONNR^pjk<(ֽ^k^ X@`dyy9 >|nII)cr4UըG%r$F/SNH/ CYYիWEQ,**M'O 0_WWpȑZi`0 yH$'-C՝FR~_<@EEFYYYoooSTp8JJJBzSSS. 2 Q:QixN]k4tr#G`OOO]]]KKZN$N+++ =ݖdT*sssjk V/ "r斕y<ׯ ͛7_~vvh4xNʥVv]R>(h4 ӧOMNN_- ) t:CzQPP<44] Tk;RfC ~}7n |>BQYYܼ477,XJrΝajjѣett477=Bb6$tWEQ744dee;wOOOnڴpDRV;y? =555::j#*.@Ieǎ;=ښ=jfjqq_okkkmmEqllΞF$#3m QJ EyydRT'N)((uuuh){wĉ2\^^Fc8.))LT# v8#G檪*Njq~`0(Jv^  JFS>_ :#??^K&N|nnUJPpo߶%%%֭Co޼P(MR("}jNf .LLLBӉC PSS700֭STjl^6Q*Hln̙rbᨯb^2ݺu`FhJL:Hh`4׭[ @nnnqq j5++c||\444٥%ZfԞqR:H-jRF'''Ct2^^QQf GM&EEEyyyP裏>[XX@[2l0(Q-((;~C=DGii[o588XRRR\\Dz{{/_<;;t:.<@l555*jzzիeee=(e6~o24M0<~x8E퀑S>3xwaz/KTVTT ᧞zb1LDbnغud :._ID2tVQQѵkמ|IAle1ԧN<:mddN!/daFS^^mƄ!//OժTsl  6z=~"chZXyA/vټk.AΜ9sڵd2C!ύFL19@MLLNMM=cyyyƍ===n{߾}YYYJO6::z-ǃ>gD3D?3cҹ,KYYmnn2Lmmm b~~=;;poHq7 A ]PP x FS__oX_xcZ3d:=ϺKu1ͥf>V577wƍ='OVVV&G endstream endobj 242 0 obj << /Type /XObject /Subtype /Image /Width 22 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 22 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 226>> stream c`0b@|XMb> YsE&qEX\"s.HʝX"<猞Jц TQ{zx@x*q\P;d!'b ps:@eÆ(@r) uS@ ]}CCXx MԹ6< 10AY@@lŴ&X \ jAfXv@CXiJLU([.C endstream endobj 243 0 obj << /Type /XObject /Subtype /Image /Width 22 /Height 18 /SMask 242 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 22 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 18>> stream 8c`` endstream endobj 244 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 391>> stream 8c`0b p@(mftt,[BH d>(k> Ys) 'S0lQJgbhCTƹ6w!~$,`sI H_s3z**E*P-@ 6m NPLTUHy@bR$-cٯqHq"f]0VA\=t@ǎaC!l)++;ה>(!m9%$SŒ)`@(4,@sIcB׀T@I?KO?&s3lxvbaBZ609ZK0```/SX) D?GV$1!_Ҕ"\ =" endstream endobj 245 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /SMask 244 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om_x \ endstream endobj 246 0 obj << /Type /Annot /Subtype /Link /A 247 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 4.1092 147.7500 116.6092 ] >> endobj 247 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coveragedeaths12.png) >> endobj 248 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 249 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 248 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16141>> stream xŽyXTG>~i6Y7TAQQD5AFQ3&љ$QI$fFEjD%FEA7٥١Vսݚ̯~uԩsowWN{W7ol6f /_o>3{$I$3UD˿$3@ڼ["4~ԩ ,~zxxU|cǎ18BJSJUCD`O˗/Wlْe˖4GS<%u(''# h.] ,$IС̱@0gNflXҖD?88РA8p̙3a4;21̪mҊPZ9f="3dȐe˖ƾ} FB#0MyP^x K`(tyƦB45 Ι3FFF@~~> E[Jե膴 Ǘ𻻻OG:z(5 %셊APѨhN<4@ȏɻ]tgh%yyNʇVj )D=P۷o߼ysԩ 3a L9xCQbg!ų(1M(>*AirssϞ=D)/(Kp@4 S*(JPBpA򥎙@6h uww?9j(懰0b"fQT/1=ięL|h(^'u<@<iPQF MʽC1CEX)IA\"PJͅS26gۄRaruu /]~z^ڵnFeZeV)_t|Iww_~I]՞FbB3 աKD^x$I6ltE!N(mHHȝ;wZ[[͛{UXXsκsι<M *rcYxggȑ#OcǼMLﱓ5cWA!'O +V466롇 O40X`Z a5eʔk׮͛73f9rd}}S/L&G<.0E3gN}}=;wܹsP9[&<4ŋ㰰0}ڄ JPLӧϻヒdIFf!u(mMMW\ $MIkPE zD{ p RYLP6"?!7iI|\TTk.߳>HkǏQ Im[[[DDD޽EݾGAT9[)+[(~<E Hka+Vprr"Zhߢ%Vڇzh=p[dy,Dǹ3 @{P꘼RMFFs=wi>n[DT@]Id)<ߐQ'|3VjFfuGNwvv:L mFQhˁ &!.$gENk-CQ_$)V|{1#NL8>!Oe0,8"A3a!+lƍnޮ7mDHt7@r "ŠΝ;`25!% IV|>q$$$TTT D%kW$YF(Ed4d9ݼysfffnnnBBByyh>åǏy&$%%8q8$}E*B(f;vxΝǏ P 57-}m"Bٳg><*|u Lg10{옘̟?| rWU LN8u(R9rHs644̟?e+,Ï1 $IZ///NrJ,dr9&&( 7 ƂS{%&tpVh1"\ _8q"[{B"d-3r@YPP?/ !TxIHQ_֖_7 |E&ZHwryy:6\SFDDL6 +A|La9Z+"c㛌f1V]e !ȧ8BȖvV毇ש]`@)L4ͩ8_NR,efh g$?ƴǀj?(zͰ4LJ؄BiϘ@*q2dMtREcң'OYBX1UTK'Nc|z2"Lp*2hzޞ4cTFcz8T&ҭBC8JP zy)5)O 1%AF s ҮZjժUJ QqR>j{24F#}YO|;P]<m%f$QJ@iI0Z:TOT K$ 'jvA9A0W*pԡ5%Ɏϟ􅘘___+.F2,UuѬRA%g*eB !H 1:Dxf^%PyT̙3p[CKh05<[7B(ERIrEǚ2JA J$ !TZZ~$2-US2~@MڞpСbE,Zf$I}]cc#+r\Y"kBRuVN7x};wR*Zm̙;ꢠ Iյ^ԌcO>=>>o߾_u|||RRz0hLZ{gVVD].k#>|ѣGwvv,Y$--Æ <ɉVT >Sj+ڹs'/fZ[[  &/(`fU&2jkkku:ɓ׭[B/+V^T6OfϞ} ,ZA^\z>碔mFjC;fa_Aؓ'K=@isfDV$cPNTEFJC${yyyRR݃Gp1LțQXFFG]~}GGW\Eg8+A Gȑ#$]ɓ >1:o TFu1cƬ]#00p߾}UUUL߄ /9rrr wަ&g3wz0Ç۷A|||f̘A84DWN!!??ƍ!!!z~ɒ%3fw.J̕`BKd2~'|Ԩ)t'}E=lFR0ϛ@9vXTTT߾}洌P}e7T?>y26ЎlJyU"&t{R0y&"\TДVu#m4NJ3^ *LSP3y}l)Ғs*PH|YEP% BLPV*PwygԨQxk?Y򌍀uҌ$"a.рt+u(!tB2©#Qæ:' *&0ҜvpV O.|P"b*P 8ƘF^9L&999>2 <4?fJ*ɓ~^߸qÇjZ).* ͜<[oWr2wر:[|͹nJII@ៈ*("NA\XhM2B1aONN.//߱c;<@@>|꧟~*++۹s'~r{n? %*P&;;;,, Td2899/X.]Ti A]h&!WK&B+ aaaxcgx_8f$Ӫwً- 0-...<<8 =XK(N0p|kl2?lAU"DT|R|||BBB؄é?p;v !C7tuu[(~2dtuuu\ww7)ZˋOH* 0,J]RBfb"9oh87rW^@ !Pڶe˖)I_ڇMzU>(L^Jջ]ӗPUW/fJCz T~ _S '=P<P޼yoc h7xOWJMA>4 `R /B(h08 ֯>_+(g(^T(?8,VuUrmF\saޕ2E<Kd3Fu9NwZ-JS0h&S?aiܻj -=yy;6ꫯ:;;d;#; (q[ڵd2ڵ zhhhhz^ԫ4߷nB},|n*uJ񩭭%9-[L&SttΝ;M&Ӽy `Ϥ0EN.&Y+]񁶡aŊO>իi~\A ?z&J) 9.4c̳b+pPL*Azı7pv0 U\0ԇ޾f{;*33mwwwCCCֶ; &څiɰMc((adx =|$h?clū?bI~gݽgcU#-@"lHLF[ڵkG$ʕ+nݢȨ2D7ys(A5B_uMM B(99VnPVJ@~*oʭ[gff>cl7AZ8Bz~ gώ( ӵ*bD&55ʕ+ʶmrND.]]]ǏgjvM|2W :ٹ_~...uuu#U\w/bf!P} b./d@f.́bK,B_fT+] %VL|h[(ѣCBBZƔɱIsfHF$,b-!GVnL8$fd ?2$"1>TNh*'(?Lxg"(͸ ]C1e XBc_gaF z~TPPTU_h8|jme(fweS]OgE !"cV&iCpH(KL.CTUU) 6PhSRR:7enNޣ%B%ef~ ?f=ҍm_Wk{ 'If!hLqs[Aէ `݂f688xڴiG~衇$Iə;wu:ܹcUHdZj"J"dmhh:u]\\GKVԧarVKKKRX|@jo(WS2(?e'={v¶msȑB)49z^J p͛7FFFo_RXx 8\Z!r}lvR_TT)-B [WWd-ڋ3 lUѱ?TaY KJJ0?77*^_QQ?\ IKgI= z#L"h(rYVVHBBBҰ.Y ocb[`2$me"9 *..޼y{fؙQvJ(=74} 6333..nݺu'ニ@y3Iw+K cǡ_|"##=&!W29.x;kp]JPNwƍۭ:ߞOy +zWS,L_THbK]߂|Ѿ[o0( OA#+]b*4:BlJI&+b#/LΝkyb?M6ڵf55 I US_L6 JvS*쁒-H|%Ii$VDIT%//HYiT]]}o*V;/߳f.͙K-*𹿝q=BOJS<5kɿ -@ {(QH&!EHB o4 =S-CIٗ11P4E94a߀|ӦM[of#oS~eɒA'}(gP 7CzAaf\RJ3o<&(i*13bf9UT(ࣟc)A!%,*SGԧx{{  !wuwwggg?<>W7Dt+ Kߧ {¸ïJP²m۶>HINDOzxxׯlٲsԨQhР6F;ydYP/s"%(FFs,XۧOI&b+ ;Ez-uV<*))ٲe˴i}Q&d] > ZSnFRI.L󋋋c&ۖ8;:M# EW Œ! G ۧg];q(u1,%%G.__ң"M|H+4+10PhVmBi 4/]7M(tI?}$$ n @/B(KYYpg90<]`=/nL(S |,Wz"PANnR{ u0W(لUlJ[ZZZ]]hTylKٮ:yZ7hTԣ_BYC{ Ƿ𮄅:AG XPq$1;jYCi_>vXU{)3Z+)W  GʉN $! M; x6dw0BsK{ H^׬}fGpΚ5Ϗ7kB*[}]pU/*CeVfzy$cBj!񍍍}ݵkSO=S/B;b>(Muv0[ˍiKC]x1---''gɒ%0KxmCJt:6B(gTTԐ!C0\@@Nkmm4i޽{ 1T)tUaa%k1!j6fLTa?,f $OMbG{\ `M8jI6 ORXX p?w/phAA||B$$3 EJ[ZZZYYںh"x׉Ă =*IRjj^y ꣢ DwM6შ(<g(mf+ gNIC }>b?#Dԛ?G tBAy)>^x100p T3*Y$B% IR~ggxXX; "qS',9$BSh(!gDR`IB`f"rPɓ''&&=z4,, i{BM`0!p4L2yy?@7I4%i(.L0}A^@8LJu(mGGݻJ+lz/!zH@7@+%Yy'6IGHhQo,%dX)a nښ um!™ `"^zM:&;&؊]hcccsF//7$! tΫ=]ΊP h___p,77wݺuG}-;B*e"!%b<@ 6lP\\?VVV=zT8*}x'|RTTqƼR,;ISJګBo}TYxqqYrpgj>%~~}BH ...mmmq}}}GGGmmmSSSVVec1dz+=\4tF8ouu5B֭[!άk!P.aFOA4;յeqKKecgqZ.?%y&3#Ic=BB(I޸qc̘11͛7!ݳf"A؁ Α#BsFfؙwߙL&GGzBF6:5՗?@/Wك2Guvv>s Db(F1SZP=@/I2dVڢ7nlڴiݺu!Vo0CDwMHT8IMΨ2FKqq9HWǫJ [,<z8Jvƍ7nyqoOFz-F|d|CS9")AqM_Q*H+9_68 b&-`&SK-𚎖ElnGN͆[]p~^셺{R=PS)@;@@$#dPZ^ḔFl;6MlDX1JGy7ˁZd`QXl?`cbQn)pЛ}9~<-:wi/~IZ&%j}DXmePS mmmoߖ$6w3]%$ɘ^= zV%k*I'N9s.**GZ66^ 鍝f{C :u~g}ݯZQQ.JPt)}t:R3@aJJWalGϏk-(F\z3^zi r_}t}v -(/O0޸ѱ1`zon$)??_w*oTؽKz𓛛/?ۃSO%Fs)0L.]2L&i…˗/f%|;'ɲ.D577fsccY^kjjI6H+* N㺺N*:`0IѨ"K]]]GG]c6$Êƿ"%??Cݺu4lnn;6442TWWwwwӕ]]]555Q !6;9 !݆)'O|O>[sYY-bŊg}Ν;9ܕ+WnڴLLLݺu+cP~fsBB»ヒ)K٫W~iׯ۷z7~gW\YdO?D+ڶm[@@/BGhYo߾'VJNN?Io4Tyyih---~e˰f͚3g`IٮXO[[[O8hVZ7 .䔕@zzÛ׭[7nHLL8qbTT޽{qꄄ7n,\8}O>`0O$K֊,yW_}[O6fիQٳgsrr}] u7n8887ʕ+2+++))СC+Vɓ'/^s5kր(#}322p}ZZZrrkUUյkBۻ~ᇟ{9<0L;vӧϪU^|Eo޼yKoƌ37779r!<<%%%'N onn?~|޽&M; %==e 1=I&ܾ}3))?)SBooOsͲ24|۷>&iȑ~~~ǏߵkWxx ܂:eF_RR/^z+W{Gx~eeetT??aÆdgg?"".\b6[ZZBCCw=vظ4a„o%[)S_xgdd\4+Wl6&&&?u_Kkhhbbb.\ IRQQQbb_~9ei#:޽{ڵ{UA$ɔ_vwwFqٲe=PPP_|+ |'x2 xUXI\YYyALiǎJյ{ݻwL&>%%eرϏ"ο 6EEE$ VZ;_Fc}}}YYy?ܹsBᎎoL]&N8s̸8v͚5K,Zf imm5 \Gdp+,, GvYWW$45k~h>`ʔ)L:09;q~706l`]d61v5uE%&&*Sg977nf<Ǟ7n1ϫT`JR?A=ycǼ***BCC}{Qa eSN}םs:t JI fž5zGӧOaa޽{{4gB1GQWBb_}Unnw}};\]] Jim0SΜ9j4={v֭;.zFW޼y3666$$ &JUA途+WM6(Ba᥆䠠K \[ endstream endobj 250 0 obj << /Type /Annot /Subtype /Link /A 251 0 R /Border [0 0 0] /H /I /Rect [ 500.4120 766.5743 516.6750 776.4950 ] >> endobj 251 0 obj << /Type /Action >> endobj 252 0 obj << /Type /Annot /Subtype /Link /A 253 0 R /Border [0 0 0] /H /I /Rect [ 256.0283 711.4553 272.2912 721.3759 ] >> endobj 253 0 obj << /Type /Action >> endobj 254 0 obj << /Type /Annot /Subtype /Link /A 255 0 R /Border [0 0 0] /H /I /Rect [ 272.2912 711.4553 288.5542 721.3759 ] >> endobj 255 0 obj << /Type /Action >> endobj 256 0 obj << /Type /Annot /Subtype /Link /A 257 0 R /Border [0 0 0] /H /I /Rect [ 497.7503 711.4553 514.0133 721.3759 ] >> endobj 257 0 obj << /Type /Action >> endobj 258 0 obj << /Type /Annot /Subtype /Link /A 259 0 R /Border [0 0 0] /H /I /Rect [ 154.1310 687.6458 164.9730 697.5665 ] >> endobj 259 0 obj << /Type /Action >> endobj 260 0 obj << /Type /Annot /Subtype /Link /A 261 0 R /Border [0 0 0] /H /I /Rect [ 164.9730 687.6458 181.2360 697.5665 ] >> endobj 261 0 obj << /Type /Action >> endobj 262 0 obj << /Type /Annot /Subtype /Link /A 263 0 R /Border [0 0 0] /H /I /Rect [ 172.0223 675.7411 188.2853 685.6617 ] >> endobj 263 0 obj << /Type /Action >> endobj 264 0 obj << /Type /Annot /Subtype /Link /A 265 0 R /Border [0 0 0] /H /I /Rect [ 188.2853 675.7411 204.5483 685.6617 ] >> endobj 265 0 obj << /Type /Action >> endobj 266 0 obj << /Type /XObject /Subtype /Image /Width 22 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 22 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 226>> stream c`0b@|XMb> YsE&qEX\"s.HʝX"<猞Jц TQ{zx@x*q\P;d!'b ps:@eÆ(@r) uS@ ]}CCXx MԹ6< 10AY@@lŴ&X \ jAfXv@CXiJLU([.C endstream endobj 267 0 obj << /Type /XObject /Subtype /Image /Width 22 /Height 18 /SMask 266 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 22 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 18>> stream 8c`` endstream endobj 268 0 obj << /Type /XObject /Subtype /Image /Width 20 /Height 14 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 20 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 135>> stream c`@,L %Yp1DX¹0}!&`TB0*x&&0L+3P3aU tM;vJyGlmNh `9;@<c-/ endstream endobj 269 0 obj << /Type /XObject /Subtype /Image /Width 20 /Height 14 /SMask 268 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 20 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 17>> stream (c``PV endstream endobj 270 0 obj << /Type /Annot /Subtype /Link /A 271 0 R /Border [0 0 0] /H /I /Rect [ 204.5850 662.5601 220.8480 672.4807 ] >> endobj 271 0 obj << /Type /Action >> endobj 272 0 obj << /Type /XObject /Subtype /Image /Width 62 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 62 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 399>> stream 8c`0b ul;7c B*fm &Aɚ3Fx5gMٴƎ c`rH f: Dy\( o &sSsm BǷ\8$@9܉ljG39RUwAFg*~:DP%b& MU, J\9"DY8 4=t$; Q>Ӡ~sHn9%$S pD@( JADzǀQ־$ HYzy10DaCL CB;вYu$I 'TKClŴ&v}JY\l,5t%g:`E+M*"[7JH. endstream endobj 273 0 obj << /Type /XObject /Subtype /Image /Width 62 /Height 18 /SMask 272 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 62 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Oi  & endstream endobj 274 0 obj << /Type /XObject /Subtype /Image /Width 20 /Height 14 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 20 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 147>> stream c````ba6ؔev li`+1.8D'`V@aH[8l!@Y'U`,$37-fj #s`+00(qCτz>8À An6)Q endstream endobj 275 0 obj << /Type /XObject /Subtype /Image /Width 20 /Height 14 /SMask 274 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 20 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 17>> stream (c``PV endstream endobj 276 0 obj << /Type /XObject /Subtype /Image /Width 21 /Height 14 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 21 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 211>> stream c```a&]V3kTjEǜ. BXÊ*= gZ)D>6SZ HSc`PPݱ$z! bI121 QE:P킘 et(XtHP h\XChe U-[)LϾ 5@M2 SZ1@B; endstream endobj 277 0 obj << /Type /XObject /Subtype /Image /Width 21 /Height 14 /SMask 276 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 21 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 17>> stream (c``  endstream endobj 278 0 obj << /Type /Annot /Subtype /Link /A 279 0 R /Border [0 0 0] /H /I /Rect [ 534.5565 630.9316 550.8195 640.8522 ] >> endobj 279 0 obj << /Type /Action >> endobj 280 0 obj << /Type /Annot /Subtype /Link /A 281 0 R /Border [0 0 0] /H /I /Rect [ 93.9735 607.1221 110.2365 617.0427 ] >> endobj 281 0 obj << /Type /Action >> endobj 282 0 obj << /Type /Annot /Subtype /Link /A 283 0 R /Border [0 0 0] /H /I /Rect [ 93.9832 583.3126 110.2463 593.2332 ] >> endobj 283 0 obj << /Type /Action >> endobj 284 0 obj << /Type /Annot /Subtype /Link /A 285 0 R /Border [0 0 0] /H /I /Rect [ 26.2500 526.7558 141.1343 536.6764 ] >> endobj 285 0 obj << /Type /Action /S /URI /URI (http://www.math.clemson.edu/~medlock/other/SwineFluTextS1.pdf) >> endobj 286 0 obj << /Type /Annot /Subtype /Link /A 287 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 395.5267 147.7500 508.0267 ] >> endobj 287 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coverage1220.png) >> endobj 288 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 289 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 288 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16064>> stream xitǕ&zVT Ka'P"(bkYg5ȶ4HOg'α4>}FjҲ([<iv$})(ԚGȈDRyo 3qͥ2cB۴4afs{{پ};9T__fggvyᬬ,544J$DffffŊ---p… yyy###͛7o.,,U2 B'&&gff/LLLfdd*k׮n5::vfKnݚ b)--miiQcxhQQQGGG~~~~~~{{{(zzzJJJl6[8V$c nAq6(pCHL̢ Rq 2Jsss9XIjq.=V9(r5䦦& ggg׮] Na`@ą"Njnn@0T@ojeAVkCCC0裏^oqqH^^4S m5,S=(B#x)pڒS(S/((w,uk]?T9N7; R3P(J[f  pPz>]drzzԛfl2;k9((T… .\ 5/" nD*x_5@`iwi$`5"KJ=z,'[(f߻=R1PvLL&9qÂ-8nsiCq@ kK33]HiQ[k34QhkgK&cM088x…Cq^^lϩ*9$ Kh&F%RJ,&٦PRY(NUN+fwap=ݡa1XgfgfgDڗT% B#:Bx0]wߛ {l&7D$ݻER(rϋjVQ 1N:VsFVFGG$ƸOTUZ')Z*O JB!$%h ͢Vqi'Iː mB@ @*ڸqc~~>ݴiS<okkۼysFFBhʕŢp6bЖE^2:OK@dD1 >T_At?33WO@8'Ճˆa[pw\%H<'E"/4^Cẓr%)t8uuuԈ`bbdžVCa0 ysC/Fi N@qie\$  VqnnnUUUyyv$;/< 8"{P$(A1u'U\6D› Α⬊ *RU :ڎ\@WFt\"I"H$fggl6geeqù/[v; ^3([*(ȍ4!&''].W<}Gx?hw~[>-[ƙH" UUUy(;\oa6uX'|˗o 쥣/pR${D\|X$BraBT@f,_|xxx``@WNE2c`"hk;w&=nlCZh hg[RIB#BpmP$헆[VRjhٸ56@ D۫vrX&zDž="BZV1-SX`٣vi%dVUUXm/H#f^n9#H€A0zt X@.JCC/j* "/Uۄ B}}}֎D k0NY(E;%jQYLjAyd`r{0~! I bǧGiF@o ,CQƀzG%{Hd9:9(FT5立_~W_}:gW=Ur:lp3UZyoP!x  %&Xc!{ 4k6P4-ٔJvŋ$ӧ2ve̖X6ú(A Ccc2ἐ#`v0ںuk<}GFFFFF*** C~Y#ftJvȎhevjl "mVZE+**b`HR&k#MũT;ZC V+W2,A)"!seÎp .x%]j3؄P( Q,UTB9Q=SHLߪ ` .ͤotO^%q'=4 Z`zz`bbBocvGYAi-3̓9z(Ai*ԬrL} '9G*1ke8Ap>Q`/e [D"mggg{DbCYג"2g۲%WKjzPTdB% Ht@ MvW@QK~lmQڳiy`!"r B&/g(0HʼneG@HF:==rJT|b6[1^_B<%o޼`l~pzK}K 914PG`] !7̈~CCC;v8rMaFYIu'S}߿%]jyS+i7W:RJ^z<|0%hŹeE ԅ Hԅʂ1㥥˗/':u5k۷nݺaA믿=8UUd鱍#b'mJ1Ƅ Bloo@@Q/u&IV8. >fF{.[ !TXXINF*=ؑRDJJv=P+^&PdlmmrssP E H'h#E%X,ٹaصkLJŋ-6}BA ق2wT,% 9;e.%~z!K.YVŽ ;dbN-4<IHXąh~2Ldi<`hBp40W$CCE>hD>ܒT,zK5Aў m@Y|9`5S1 I ڱ^D+鈅 t t`׹l֐TD>M(n-iŒE J݃V&.tS Y6i=!\F|P#o8ױ}qݠģ>J 0,QTBX]Ε)}N+*B\p8mDjO*4eW&GA_5N a.)Ggg&S)4bF*F;ލ}2_% @db?l~衇^w|f/NV_-By^p?>iQJ ={ 7{wXg4rR@P0( cv,;r}[oH$D?NJN_J@$YXx [X8_AQ \?uıX'|~Y6K&Pl6]t)sfffARO 7ooll{ꩧjkkkFF85Dr9Q"` E)AnB@O<^Ch4nݺӧOb1ߟL&}dZuuuuuuk׮ep\錌_|qd$d2sssɋY<OQQdF7|30zEZk׮u\b@`vv#J*2yA F=T#9s9'| }e˖Z__ӳfJ#77Y,^z̤Ǝl>oϞ=7|( 7@M$//djjE?''ü3w}wppp.B 9~zӦM"Lin RlJO.%e* %v)ArT$8 ¬O$֭D"1)n{oJVkNNn?tЎ;XolXVZUQQTWW9s>B D2cY]]z~bzv;Ձۊɗ.KP~DL2yXrꫛ6mڶmB`-ql&s,\?w}a&G666?%o4.4HfY -HU5$AB:znp7J"P<>۸q#[x```ӦM.8((bE4:JjJn[ڊ%(PIʜ?{˗6nhXXJ ,1T`ڠrQ04 J@ np7o[~gffbZbqR8-mEAל\*D@Ra46ƸbI 5r7bыF, J.[=dЅ1(TEAI3_HsS-Kk+fPd}2w^ #^b+ LtN, HrR4DM8QH MiM:PTkE7O>$;"OzH?nǛTU;nnw{{n)-- pȑ#+WV5;l%g,T2lkkSe||<++?N$7nlkkX,Pnbbbٲe]]]W|˖-kjjp{{)((PӑHdٲedwsSN)2;;U\\1޿KK yorr;[m۶9Ϊʙ@ PSS366j*r#$.;ZZ$;sR.Dfttr vwwY%~rÆ n{vv6 R꒒rQZZZQQחg6KKKv{QQQ" WU*رd2`0srrJKKڵkE>&cbhlD˞\q. %=9bXGGǪU@柤611A~a1M(RJ|f9;;{bb"Lr#c, b9Kڻ}N( =|fJKKY1i\ӤBsCCիf&iQ?"sLtp)UU5Htww;vĬqI#8߮G8am(CO BBqudL@q!ɣ@ 33sݩTm&MS9' ކa+fzrqAzB 3Mɣ| i=D=ֈ2R(In#(qW fuNKP&i'>m.48@iCQU`/ %-B3܆KևԠ! Ƕ⚋]j^PWj [ܠbq荋J$h E%]V,EGFϤL P-Eez3|cKAX@J:v .ȆBP*rn۠3n5t$" t%|V)[o%pH(۩8GPoM@qJ)!HJO nA=ztddr}[=Or%u_&Iuղe8M(7JC/PW%BR(IYzġc27FA8p`߾},2 m98x?Qvz{EK%HQwʕA[.pޕ-ܪ( Nu'%$2R@ /*f:c % l@VVփ>H˗;N|Vj69w=UQs6ݦɮA=(iq61}eK.wqΝ;\ee%Ƙ~@qz4EGX9+#$Rjb@$Mk[eWUUUWW-a})۫tX/&@K$bt:_z&P\B'Fhc( +9ڼcಞ$`WWAz/%]( }Q(|`cغu[,f#aTQ m-,Ti/,6{1sZjzfnW_RBӂ@}}}mmʕ+I3]z-~W2I-qMf˻v;G1gDž ܬ0| q8,]`JKnzYl[lBP_3όqc?z!H_nb z,;ήO ]7jaXٱ3 (>%xӗnU$=c5"APq64 ~'@TÍn=QqgmM\ЗHi9yCg'TU{׽bF ʊ {نՋdT,vݗΉ "7n%w[P$I4mZմD 6mR5hzZay:SCȑ#C\ax]E/sc4l\hue,#(t4HX P©=j900I/[ ~뛗B-eVM` r Ɣ%566߯t u^*ACl4}as IU3LN5iI[dPdG16,Aػw/{j ;j?g`;|V'R RpM*1 "Ƃ`yy99<44L&< ojgR+Fӿ}z 2싈/_btzXEEEEE%.Ao@+qY΋TUM ִb钅P`crx<9/i /קxJ( [I6EyK2#qs`xn#vPuD_e" R8I'- ̂29RXv-͛nl2tyjJyٛ4B6wn1$lj-j ОTpK ݭ[R/Xڌt^mAJTqN7c@֘5ٶ`-[vĉR:i أ(/Rc) H)C"@ pbp6/kq86>>(J4#nHvJ)XBvʕ+֭4F\$@6SUA+UV{m>@*i< 5|Ēr`JFGy [ul B^ۻ(7\S+& K hpeY"D?cld\,d;9Rq dR?_g,a;z4!&&&N>MmlLo">/l 1xY(ͪRT**UsM946DQ333lC!iAc*ivjN`{k6l@~*:wE A;u/%6a4 _j3O?)B ʛH: ,0"Otj)06't999X^zu}}}hܠ Su1l/'ȑ;cXFPku92%\4/Yxq6_x:qvv1HI31-#}}AvNIBA8Muي1% Ƹ!++)cl2>裂0sZ_&eSs޾p\,I=!*՟nJ 4d+ӂjkkF---}R7`[p% `v 9}r 5QZD,A fsUUƘ!Z/`DBEk?#f%EXGGŋ:ttw<˵{(sp|,OtAnF#<(Ƹ`.7żfOO5 طs3^3K^16-/Fin23233l6- 5B^" uu֤azz&3+v'1*|#.EF>naæYX-[YA | e7CJ`IB Rr7' >;כ„p'ΐ\e `R.\:fP:j ^glT(0,JvjLf=Z)%d]8I<&sX;wu@eeId/B:AM\"a޵'mBȧfg{q:;4.s B.H;RN1Bu FJ6?W_v(ɍ!ݺT*(qC @T*B&)JjRUcXMA  q3q2TU@PA;NT*J$b9V5+Jݶw woϑ }TxfsS$OY  # _|E}W^̬y7bC9q05f]Y\nwn^ѣgQ7̢VJŎ"'d2ÓLDr,38&q0LJqqզMg\vN"!Chn~i7Nd7"3=SΛLYtLB ʲJ<.d**){'H7#(OㅅPfm޼mjQ R) ѿ_,IR,RGpS/D^-W0SHÇ^Ť.\p8߹%EQ~L"xNQիK"իZ__GG!d[8" [(AzTR|agnǏ;NMՙL&EQ@kf67lؠ(Jkk+f=z4//O>!9lmm}ggIEQ>cǎ=zU^GI׉ &IX(T*Eן cQO<`& $@ c2"K>00P__O?Ib E?x6A5i&bk!''!T\\_[[L&ɤjn!dZx>cL+7c9>p@D I oK _&GF$###''~``_W{淪r\+V{>Я~;vѬtovII 744`~_cWQI)..X,g޽+V :9:=♙JD& =UR i^TTB.6N:11nݺ˗/6ʉQo޼9Jf19"#G[5Lk֬Q%Mf j! 'l BHQUU].ׁ;[ !S`E"~zGIQ% =zʕ+O>ba;tAEBs ;P۔^,nAlGTUEtM qC5'U|ԩ 6TTTqG'I:XL3'1nii)++#B4ހIDt㣏>b r)U\J<$BP e-rVvtt466^xq֭_(,2gCҙ&x PTv x Y̒L]HkhBUV!?666\[DGM{aGz*燢ŀ '(C5T2L;w.??=$rYk=J 8KB4K0 Xyĸ8KCXtS2ߦi 6s հ(k+߄7-ZaG?.&DWRC:T*w ^h4kc$' ڪWlPhHSk܄qˑu}GѨ_y]wbx vС{QG-((hjjZr=oQ322;v嬬,|-[/}K͛CPQQQ<O&7nϟߺuk4=wܶm۪~޽u__/v<>{7^*J(,, ^>---ձX쩧я~dTU|W~oo/Z-GMRDmdv@EEE 7ouɤ9z맧[ZZv5<}z֭7thvv6?I "mW 'k?ofgg;;;nݚH$B>pg+;~ٳffa].W^^lVV֡CjkkϞ=KVlN$͢###^78NKJJ,KaaÇs̴477~'@kn! FGG;;;W^]TT B𞞞@ STaa}jjj󳲲L&/--D"DB!Dl6۶mΜ9cZ#H 4L&|n9r[ou\ҥf4'qNj ``zĤ#nFeE!_zPٞLNNr$hmmMR'N;UUJ&\[N:PUujj!TQQz322, qJ"yիdUUmnn^rbٿ5kl{0W|nz뮿~lllϞ=wy|^onnc~444\z&''`rrf鮮ڶ>͖K"]fM<Vĉ 1###˖-%'if@XckleQzjoh>P^0L?~}{oh4:44aÆ+V[vr{@`H>nnn@p`8zɢ/ZҒ'Ntwwu]nXprrrˉ[)lrJKKvu{_rll%X,2>(777 8pŋ^7+++:th .˱Xc峳lUUU###ƋֳD"HVcB(LPXX855u7:NR\\yfL盙q\{MNN~zf3F))) Gپ}{fff$!9^~fb}}}Ddee}zMU57ń`0z[nm/++kΝp8 n;8믿>###777??… v"O(eggoذᮻjnn^jU* B]w]~~j-,,TUu4p"ABE8r^3Yn[vMSx}4ؓ'O*$&iŊMMMf9##EFtR0Z Dn7664IofRe&H#vOOO?~D_l6^;vlΝh> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 226>> stream c`0b@|XMb> YsE&qEX\"s.HʝX"<猞Jц TQ{zx@x*q\P;d!'b ps:@eÆ(@r) uS@ ]}CCXx MԹ6< 10AY@@lŴ&X \ jAfXv@CXiJLU([.C endstream endobj 291 0 obj << /Type /XObject /Subtype /Image /Width 22 /Height 18 /SMask 290 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 22 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 18>> stream 8c`` endstream endobj 292 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 391>> stream 8c`0b p@(mftt,[BH d>(k> Ys) 'S0lQJgbhCTƹ6w!~$,`sI H_s3z**E*P-@ 6m NPLTUHy@bR$-cٯqHq"f]0VA\=t@ǎaC!l)++;ה>(!m9%$SŒ)`@(4,@sIcB׀T@I?KO?&s3lxvbaBZ609ZK0```/SX) D?GV$1!_Ҕ"\ =" endstream endobj 293 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /SMask 292 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om_x \ endstream endobj 294 0 obj << /Type /XObject /Subtype /Image /Width 20 /Height 14 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 20 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 147>> stream c````ba6ؔev li`+1.8D'`V@aH[8l!@Y'U`,$37-fj #s`+00(qCτz>8À An6)Q endstream endobj 295 0 obj << /Type /XObject /Subtype /Image /Width 20 /Height 14 /SMask 294 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 20 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 17>> stream (c``PV endstream endobj 296 0 obj << /Type /Annot /Subtype /Link /A 297 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 186.0817 147.7500 298.5817 ] >> endobj 297 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/impact121720.png) >> endobj 298 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 299 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 298 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16363>> stream xͽyx[y/@b% ($.Ͳ؎Ik[7MK$wI{طu$Mk77vȵ,#[,ɲd-%j ; A$sh08`o~;3gE1L(W_bT*Ol{{/3Ϝ8q//Ye2PJ"Kngff^|ŏ>!$K/XRR}>PA~ҔbT( +[ O"wd8FO3H[n˖-T48^ Es㉌(Jh4F/(ό!˂d*R}蒘yAxLf HbX,>t yRm#n1 …h<W*^/h``@P(T^^>==ͬ;GtR.\쬭ݱcQ1(p Sx"#P-uLԈN@TNsssD xAłA___<yy"bV@+++:N& ⁸V^xF'HDx 'OXP(Izj()aJ`5(DnKU!3ǔ{xqF?Ѻ2A b%|y;n{<ֆn[,f+Z6ٳgVk^^D]jLLpc%O@)@P_hM$;ҵL^BиmAuj~rss{{{?D"q'N~hTEFsPLS B)Ѝ .LLLeͻZE֖\.1Ln{vv9N5%:x:({MMMOO( EԂY\Ӧ"e1ΘLi@Y 3"꺺ZB!B@ N=2E)ATVVFQP`L]D#ӑ, CC vuuMNNb1zUUU^`0+yG@.kfff֭-p&KYxH" qC"ݥ TP(^B@j޸qcjj`0H$JKK4/041H8q… ۷oyXEŲj0xG&Jjl6FFqddv=/|*ܤȻ<%Jwwwvv6QК̢6MӍO*C!ugjnݺD"jV*՝:("!: (dee};ߡd i+^EFQ`0ZO~_755766"U˄<lFG*DQb/^zN*JF.䵞JklE@L磳@1kfHYBܜfZ066pAAA__o "ȕ+WVWWyl4eB@VL f T(L&4RA8 NJ[;Z,J PSS311 T*鬨ti?NfWSFJtP*ëOd!0 !5"K /))67Ёh'J>#jVԧ> -80"ϊP*"~GGR/.Stqnnn<ymۼ^/iTޱR)VLdE"o,/dhkB>'??fݺuɉL.H"mmm=lFNwYI*'wKYuYV4+)FE[K<88S@0lll4.ڙ_ X,>mذU2NA'cI;KKKodeef֎9"ԂIC)p*(*NLLeNk׮:=@Z1OビF!LIP27\&)//OںgbYj!JzRvv~x<܌,֭[8 =dyZxp%CLp'2])(i(^-<(] I=0dggl6ڂ9NEd<+^ U(A(Bexm3#ScS|@ drݫ)!: &y^G 꼕҉X,Ah0 ^WՒ꛾oVUT$KkpppttјTLvJl000099i٪%LrI%.W@(Zn]p8Pj!BBёsv`4_yXn$anV8/^z [m6.]EœqpY89q" F-v:7nȔɓ'].ŋ}>_]]]{{;zn?)X@..=}jD"%QL.r:z?y b,5ϟjllܿ8[%AxBTaEKO"dQ$.W@\#e8;x91칹MMMUUUjvvggg{챕Tr'(4HIʆ\2LPY@TjTCBd;~Jg%9p' "m BDQ|EQt999j-3G kfH F5rD"A!p &%dV*CO {dwP *?R "W-2 GSRi~PkہyI1CCCO<]2faMJUUUhݺu<ώ;B#Lt<B999`0+++ Cj䐠z~Bs4P.bwwrIIZ^n=@0hIf%>[4=x^7 CCC]]]+++_b0,))хT"'&ot _x;v\p LM6ݼynPLYȰDQ|.]7˫Xn&dr{ٳҞe^_E@'(2 z^RMNNkylllppv\}{L/L\.zᇙrD'ɜX,OzӦMfٳUUUjZOx&@ݴizW{J_`;pFW> IS뙤zܩ{~ÁR*+++q 3/(:Bw5-R||A\rG 86(-D2z8YiLVAN≀'Df2yiҦn{Z EPk k0] ǗW2ɬLY On -L e^v:<+ ˉ4sss(}mm]ҁ'2g 3ZyL(jDx'&.^:S/2z\[Bí<ӧϟ? b߾}.RX,v̌j z^...|MP*GN'$dyȑ}k( xuCCCii)-K9ree~aCCC8]]]Dp@)5q-MVLH; &O %-/>ʓPRh:u۷oJ F7!GFFv霘0͈ 5XD8xcǎUVV~3׋pX֕"2liZ K_lF,d2[XXHH+0149|ҥK}Qaaa4Z7oFG]DÓ ϙbvY"XVJ%8zQSYYp8ɤtȗL}3 I*)(..h4 m8ڵK.Qp{{FM&11)Ҷ+ vt/ɜ|-" !k4ű`0XPP0??P(rrrм3qeltiL&U*Uqq1n }5 7l|ƍҖ.g][??ЬT+++PJ;VFQׇ7|z@>֍y ɤ@ӡZwo%o߾ |㍉c6z7+ӭ58XP B+}B Y +zfƦ?k]~LTʣuuuMAvt ("irxj3W"="]Qꔰ])+JZ]\\<99)&"u.*Ԇh*AS~!uΒH|h/pС]B%\SKxAD-aH":|WPk@Ԋq[ *8^2yE1";vlRc>㢢"RvKKK05`euc6io䓑Ēpc,xpǃ̡`08RdO>xmD"͎7exd#2H_?u,HUqqqIIDuu:K$Y4.(FQ֭ 6x  Eii)JBq^+![8ПEAؿ_ #۷oݎf{8CA41h kyyyÆ XgӦMsss T@џ5뺾:o ~ ʏtxއV^{mF -yS0t(C޽"k׮]ȫl: 菘%z 2 %ZQ4$@1DS@iiiNNSO=e'''ʘF IATg  2jdddzzzrr1˛a(#:v]i~~>Z"gsuDbΝh_F'𠚛r|c}>={z{{Z,!]tM ϟX,Ғm=WÇ-5}Ν;^f^RZdX)LNN5z-vrr:/]BFaB>UII477BKwݼS `+|6M]__뇆x≪+WTUU1;aQ'\YYAqhFRQt TTEp)G"tҥFbGTG#_$cg:DNlEuu+WhPf硩AJʋ<+gtG pୈX,VVV&Gϸ%PP+rwcЬT۶mۼy3zM4r$ نV1^*]M3H7 x\ZeI`H%{cju8zebk0\%ʮ nXCC˙}\t: #)e4##]GI?4,w2A˜߿]]lZ6LSSSib#(q`}~ÇH$C" v-x}Z{&''wg4#k.O³[1J#O<ݭ맦~iT"ju;6KPTCbcTLNNƐIp F,V '%c(G%9r9a@gR<~z:fEzqp:[y)feRCiV`tK_khh}vGGGmm-ԉk%-,ek(JlRqp^1[22sbƩ TWWzvrX]#㇏OX`f4ֺQ_yB1kpwy.=r,dspS7# BjM~ǭ]] # ->hlƒ1r|rd܅CdV޻2Sd>1*݌XYdaRۆIOB!X;͞^Y2X`/QY+%~Al d͋\+,jE9 p@";311122gϞ[nY,VPR{04͍hkN >=#Q_yZ}ƍ۷Y᳒3WRo~V=O$q:UUUCCC wTD9 uuı~_:W (P/vXR-[0t8.\xG6nxsO@Q ޼yʜus7dƊ IJOOh2xСCZv|||rrrǎh4www}P$ z4*4#` *FýO𶶶(&IÅ֭vD2"=o.2K إ 1Etvv ~AAA ) b͌vjd@OddK?(CfAG~P&>FIx74@ 0p'`O<>}CWw J;wq *a̎Bt KHaE*1c'0>>~ajzzzddgffҒ!hHT`?Љy1!U]_~vZ#G]2*-v$?)9W3LD"q5j4#bD"Drss'&&t`oýu;9cȚ0Vv1|n4(RDH&F= ۷O|eHDբLɐ',--+TJ2 .!Ytbd\x,7e+sPD2YK̻<t֎T~Wh8li:#pڵk hp8F#6  sϕwttl߾=?S<  X,C(3<#3W\lPHuuuutt^/}>1F'@> 2 `4/_<66 y7xC#3hR=XO %EyA1 eee/^v@LAt&);;н~R;==裏JoϞF^+liiA-%D"a2@ U7^]p-cf\|*nj6;´D3P#<crg 﫯1gGixI 뭷9RJRW*6 e/T K/)}[s`"]y O0R&>ɤ41sZݍA2S@#c~P{j8k-<%J@ ^5'Ҥ%EEAw$tbx anNIpLDpI ES3ҭxA^_SSs֡f=:::>>l0LSsE8-QKKKǛANѱ ƷC_W+[[Zy~@fez0͏<JH>ԩS555֭zNg6[ZZuL(\>4#7!7n8[ln^# GZmyJ۫("zŋkD}A65B KwJ+ _zci?>- JR( E]] Iųg'"T43(&N oJۿ = bc# rJ͟0J%H+3 BNN:y,TUͧ!Q.-_jy`+@rv5" y>H3qI$Dv>X/D0Hxފ c /lyyoVJȽS4q۶| j/| @peŲby2::*`GtrjSng|E2dwcYh(, { SD7VOw--- !;;/,uZqTd2qKZx&1ju;\>q3ītw6RƉ łcNY(A2Ph4*)8S{ȚڧxGXyf,t $˗/[H$RXX VqNСC. j{{{~'Nh׳慌BRF8L9sk_z.\mooqF~~͛ :%}Pnzf\G^~vs^ BOχB!xdd$L޺upppl6oذ5/?Gjܥq_]]NNU^?11!"$I}-8QQbن?tPYYن \.WNNNVVk^(g3PG=p;?SձX }u&J5%"Iho ~H$$w ǹ@ gg_~4khV`0 qUiI>JQ2Wv"UA/*C- 'Z.p8! j2)qb*'V1#T J_Zwf1B@k>,[&=Sz!P%F. q49wK&Cܥt^ĘHP5JԤjm[R!RRBLrTvI΅www H[/RV\-TDQڴiht\y!P|IǘAҥK6M+0I$1CRL&֭[d2 UUUIjX2:2N?}tvvӧQ|ii)`g\1 )Μ9nZKJJ:::^ ~?;` ee&J-}Jv:thpp0;;gOS,..r:ډD"''Z[!HqVD򴆑3<Jg833˝N\NNKR1ƨWsRJFV8`٘_$BD6:رc z8?H Qu:$xm6 և~~$FS1R 딭HIti˘_saJK)#ߴ4h"L0(G*SfdcQS4"K8ò)cFίfr$"(Ը<>r{+pjH/;/䮌Ӯ,q0a,{'qΈ}*VbF&. b&a c!fh y,=B22E#ġ St67`͋~?c}9R/ (n'ޑ!mV`h ˟Dbtկ~e0v޽sN/ 07b%ɃFAS7~"˧iCvv6nRv&Eb`]BWWWJ%&TEYbdx)E R$H$"QńBYz6K&<'/T· EA ->+R G6뫭UTя~TVVh$ᴘ `g;w߶lvud2T*ZPUZDM"?}>,jllyyyEW@ī'0HrJII :sέ_'?IGGL$K.mٲۑH Joqԩi #1A>ݻwONNR^pjk<(ֽ^k^ X@`dyy9 >|nII)cr4UըG%r$F/SNH/ CYYիWEQ,**M'O 0_WWpȑZi`0 yH$'-C՝FR~_<@EEFYYYoooSTp8JJJBzSSS. 2 Q:QixN]k4tr#G`OOO]]]KKZN$N+++ =ݖdT*sssjk V/ "r斕y<ׯ ͛7_~vvh4xNʥVv]R>(h4 ӧOMNN_- ) t:CzQPP<44] Tk;RfC ~}7n |>BQYYܼ477,XJrΝajjѣett477=Bb6$tWEQ744dee;wOOOnڴpDRV;y? =555::j#*.@Ieǎ;=ښ=jfjqq_okkkmmEqllΞF$#3m QJ EyydRT'N)((uuuh){wĉ2\^^Fc8.))LT# v8#G檪*Njq~`0(Jv^  JFS>_ :#??^K&N|nnUJPpo߶%%%֭Co޼P(MR("}jNf .LLLBӉC PSS700֭STjl^6Q*Hln̙rbᨯb^2ݺu`FhJL:Hh`4׭[ @nnnqq j5++c||\444٥%ZfԞqR:H-jRF'''Ct2^^QQf GM&EEEyyyP裏>[XX@[2l0(Q-((;~C=DGii[o588XRRR\\Dz{{/_<;;t:.<@l555*jzzիeee=(e6~o24M0<~x8E퀑S>3xwaz/KTVTT ᧞zb1LDbnغud :._ID2tVQQѵkמ|IAle1ԧN<:mddN!/daFS^^mƄ!//OժTsl  6z=~"chZXyA/vټk.AΜ9sڵd2C!ύFL19@MLLNMM=cyyyƍ===n{߾}YYYJO6::z-ǃ>gD3D?3cҹ,KYYmnn2Lmmm b~~=;;poHq7 A ]PP x FS__oX_xcZ3d:=ϺKu1ͥf>V577wƍ='OVVV&G endstream endobj 300 0 obj << /Type /XObject /Subtype /Image /Width 22 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 22 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 226>> stream c`0b@|XMb> YsE&qEX\"s.HʝX"<猞Jц TQ{zx@x*q\P;d!'b ps:@eÆ(@r) uS@ ]}CCXx MԹ6< 10AY@@lŴ&X \ jAfXv@CXiJLU([.C endstream endobj 301 0 obj << /Type /XObject /Subtype /Image /Width 22 /Height 18 /SMask 300 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 22 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 18>> stream 8c`` endstream endobj 302 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 391>> stream 8c`0b p@(mftt,[BH d>(k> Ys) 'S0lQJgbhCTƹ6w!~$,`sI H_s3z**E*P-@ 6m NPLTUHy@bR$-cٯqHq"f]0VA\=t@ǎaC!l)++;ה>(!m9%$SŒ)`@(4,@sIcB׀T@I?KO?&s3lxvbaBZ609ZK0```/SX) D?GV$1!_Ҕ"\ =" endstream endobj 303 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /SMask 302 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om_x \ endstream endobj 304 0 obj << /Type /Annot /Subtype /Link /A 305 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 4.1092 147.7500 116.6092 ] >> endobj 305 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coveragedeaths12.png) >> endobj 306 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 307 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 306 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16141>> stream xŽyXTG>~i6Y7TAQQD5AFQ3&љ$QI$fFEjD%FEA7٥١Vսݚ̯~uԩsowWN{W7ol6f /_o>3{$I$3UD˿$3@ڼ["4~ԩ ,~zxxU|cǎ18BJSJUCD`O˗/Wlْe˖4GS<%u(''# h.] ,$IС̱@0gNflXҖD?88РA8p̙3a4;21̪mҊPZ9f="3dȐe˖ƾ} FB#0MyP^x K`(tyƦB45 Ι3FFF@~~> E[Jե膴 Ǘ𻻻OG:z(5 %셊APѨhN<4@ȏɻ]tgh%yyNʇVj )D=P۷o߼ysԩ 3a L9xCQbg!ų(1M(>*AirssϞ=D)/(Kp@4 S*(JPBpA򥎙@6h uww?9j(懰0b"fQT/1=ięL|h(^'u<@<iPQF MʽC1CEX)IA\"PJͅS26gۄRaruu /]~z^ڵnFeZeV)_t|Iww_~I]՞FbB3 աKD^x$I6ltE!N(mHHȝ;wZ[[͛{UXXsκsι<M *rcYxggȑ#OcǼMLﱓ5cWA!'O +V466롇 O40X`Z a5eʔk׮͛73f9rd}}S/L&G<.0E3gN}}=;wܹsP9[&<4ŋ㰰0}ڄ JPLӧϻヒdIFf!u(mMMW\ $MIkPE zD{ p RYLP6"?!7iI|\TTk.߳>HkǏQ Im[[[DDD޽EݾGAT9[)+[(~<E Hka+Vprr"Zhߢ%Vڇzh=p[dy,Dǹ3 @{P꘼RMFFs=wi>n[DT@]Id)<ߐQ'|3VjFfuGNwvv:L mFQhˁ &!.$gENk-CQ_$)V|{1#NL8>!Oe0,8"A3a!+lƍnޮ7mDHt7@r "ŠΝ;`25!% IV|>q$$$TTT D%kW$YF(Ed4d9ݼysfffnnnBBByyh>åǏy&$%%8q8$}E*B(f;vxΝǏ P 57-}m"Bٳg><*|u Lg10{옘̟?| rWU LN8u(R9rHs644̟?e+,Ï1 $IZ///NrJ,dr9&&( 7 ƂS{%&tpVh1"\ _8q"[{B"d-3r@YPP?/ !TxIHQ_֖_7 |E&ZHwryy:6\SFDDL6 +A|La9Z+"c㛌f1V]e !ȧ8BȖvV毇ש]`@)L4ͩ8_NR,efh g$?ƴǀj?(zͰ4LJ؄BiϘ@*q2dMtREcң'OYBX1UTK'Nc|z2"Lp*2hzޞ4cTFcz8T&ҭBC8JP zy)5)O 1%AF s ҮZjժUJ QqR>j{24F#}YO|;P]<m%f$QJ@iI0Z:TOT K$ 'jvA9A0W*pԡ5%Ɏϟ􅘘___+.F2,UuѬRA%g*eB !H 1:Dxf^%PyT̙3p[CKh05<[7B(ERIrEǚ2JA J$ !TZZ~$2-US2~@MڞpСbE,Zf$I}]cc#+r\Y"kBRuVN7x};wR*Zm̙;ꢠ Iյ^ԌcO>=>>o߾_u|||RRz0hLZ{gVVD].k#>|ѣGwvv,Y$--Æ <ɉVT >Sj+ڹs'/fZ[[  &/(`fU&2jkkku:ɓ׭[B/+V^T6OfϞ} ,ZA^\z>碔mFjC;fa_Aؓ'K=@isfDV$cPNTEFJC${yyyRR݃Gp1LțQXFFG]~}GGW\Eg8+A Gȑ#$]ɓ >1:o TFu1cƬ]#00p߾}UUUL߄ /9rrr wަ&g3wz0Ç۷A|||f̘A84DWN!!??ƍ!!!z~ɒ%3fw.J̕`BKd2~'|Ԩ)t'}E=lFR0ϛ@9vXTTT߾}洌P}e7T?>y26ЎlJyU"&t{R0y&"\TДVu#m4NJ3^ *LSP3y}l)Ғs*PH|YEP% BLPV*PwygԨQxk?Y򌍀uҌ$"a.рt+u(!tB2©#Qæ:' *&0ҜvpV O.|P"b*P 8ƘF^9L&999>2 <4?fJ*ɓ~^߸qÇjZ).* ͜<[oWr2wر:[|͹nJII@ៈ*("NA\XhM2B1aONN.//߱c;<@@>|꧟~*++۹s'~r{n? %*P&;;;,, Td2899/X.]Ti A]h&!WK&B+ aaaxcgx_8f$Ӫwً- 0-...<<8 =XK(N0p|kl2?lAU"DT|R|||BBB؄é?p;v !C7tuu[(~2dtuuu\ww7)ZˋOH* 0,J]RBfb"9oh87rW^@ !Pڶe˖)I_ڇMzU>(L^Jջ]ӗPUW/fJCz T~ _S '=P<P޼yoc h7xOWJMA>4 `R /B(h08 ֯>_+(g(^T(?8,VuUrmF\saޕ2E<Kd3Fu9NwZ-JS0h&S?aiܻj -=yy;6ꫯ:;;d;#; (q[ڵd2ڵ zhhhhz^ԫ4߷nB},|n*uJ񩭭%9-[L&SttΝ;M&Ӽy `Ϥ0EN.&Y+]񁶡aŊO>իi~\A ?z&J) 9.4c̳b+pPL*Azı7pv0 U\0ԇ޾f{;*33mwwwCCCֶ; &څiɰMc((adx =|$h?clū?bI~gݽgcU#-@"lHLF[ڵkG$ʕ+nݢȨ2D7ys(A5B_uMM B(99VnPVJ@~*oʭ[gff>cl7AZ8Bz~ gώ( ӵ*bD&55ʕ+ʶmrND.]]]ǏgjvM|2W :ٹ_~...uuu#U\w/bf!P} b./d@f.́bK,B_fT+] %VL|h[(ѣCBBZƔɱIsfHF$,b-!GVnL8$fd ?2$"1>TNh*'(?Lxg"(͸ ]C1e XBc_gaF z~TPPTU_h8|jme(fweS]OgE !"cV&iCpH(KL.CTUU) 6PhSRR:7enNޣ%B%ef~ ?f=ҍm_Wk{ 'If!hLqs[Aէ `݂f688xڴiG~衇$Iə;wu:ܹcUHdZj"J"dmhh:u]\\GKVԧarVKKKRX|@jo(WS2(?e'={v¶msȑB)49z^J p͛7FFFo_RXx 8\Z!r}lvR_TT)-B [WWd-ڋ3 lUѱ?TaY KJJ0?77*^_QQ?\ IKgI= z#L"h(rYVVHBBBҰ.Y ocb[`2$me"9 *..޼y{fؙQvJ(=74} 6333..nݺu'ニ@y3Iw+K cǡ_|"##=&!W29.x;kp]JPNwƍۭ:ߞOy +zWS,L_THbK]߂|Ѿ[o0( OA#+]b*4:BlJI&+b#/LΝkyb?M6ڵf55 I US_L6 JvS*쁒-H|%Ii$VDIT%//HYiT]]}o*V;/߳f.͙K-*𹿝q=BOJS<5kɿ -@ {(QH&!EHB o4 =S-CIٗ11P4E94a߀|ӦM[of#oS~eɒA'}(gP 7CzAaf\RJ3o<&(i*13bf9UT(ࣟc)A!%,*SGԧx{{  !wuwwggg?<>W7Dt+ Kߧ {¸ïJP²m۶>HINDOzxxׯlٲsԨQhР6F;ydYP/s"%(FFs,XۧOI&b+ ;Ez-uV<*))ٲe˴i}Q&d] > ZSnFRI.L󋋋c&ۖ8;:M# EW Œ! G ۧg];q(u1,%%G.__ң"M|H+4+10PhVmBi 4/]7M(tI?}$$ n @/B(KYYpg90<]`=/nL(S |,Wz"PANnR{ u0W(لUlJ[ZZZ]]hTylKٮ:yZ7hTԣ_BYC{ Ƿ𮄅:AG XPq$1;jYCi_>vXU{)3Z+)W  GʉN $! M; x6dw0BsK{ H^׬}fGpΚ5Ϗ7kB*[}]pU/*CeVfzy$cBj!񍍍}ݵkSO=S/B;b>(Muv0[ˍiKC]x1---''gɒ%0KxmCJt:6B(gTTԐ!C0\@@Nkmm4i޽{ 1T)tUaa%k1!j6fLTa?,f $OMbG{\ `M8jI6 ORXX p?w/phAA||B$$3 EJ[ZZZYYںh"x׉Ă =*IRjj^y ꣢ DwM6შ(<g(mf+ gNIC }>b?#Dԛ?G tBAy)>^x100p T3*Y$B% IR~ggxXX; "qS',9$BSh(!gDR`IB`f"rPɓ''&&=z4,, i{BM`0!p4L2yy?@7I4%i(.L0}A^@8LJu(mGGݻJ+lz/!zH@7@+%Yy'6IGHhQo,%dX)a nښ um!™ `"^zM:&;&؊]hcccsF//7$! tΫ=]ΊP h___p,77wݺuG}-;B*e"!%b<@ 6lP\\?VVV=zT8*}x'|RTTqƼR,;ISJګBo}TYxqqYrpgj>%~~}BH ...mmmq}}}GGGmmmSSSVVec1dz+=\4tF8ouu5B֭[!άk!P.aFOA4;յeqKKecgqZ.?%y&3#Ic=BB(I޸qc̘11͛7!ݳf"A؁ Α#BsFfؙwߙL&GGzBF6:5՗?@/Wك2Guvv>s Db(F1SZP=@/I2dVڢ7nlڴiݺu!Vo0CDwMHT8IMΨ2FKqq9HWǫJ [,<z8Jvƍ7nyqoOFz-F|d|CS9")AqM_Q*H+9_68 b&-`&SK-𚎖ElnGN͆[]p~^셺{R=PS)@;@@$#dPZ^ḔFl;6MlDX1JGy7ˁZd`QXl?`cbQn)pЛ}9~<-:wi/~IZ&%j}DXmePS mmmoߖ$6w3]%$ɘ^= zV%k*I'N9s.**GZ66^ 鍝f{C :u~g}ݯZQQ.JPt)}t:R3@aJJWalGϏk-(F\z3^zi r_}t}v -(/O0޸ѱ1`zon$)??_w*oTؽKz𓛛/?ۃSO%Fs)0L.]2L&i…˗/f%|;'ɲ.D577fsccY^kjjI6H+* N㺺N*:`0IѨ"K]]]GG]c6$Êƿ"%??Cݺu4lnn;6442TWWwwwӕ]]]555Q !6;9 !݆)'O|O>[sYY-bŊg}Ν;9ܕ+WnڴLLLݺu+cP~fsBB»ヒ)K٫W~iׯ۷z7~gW\YdO?D+ڶm[@@/BGhYo߾'VJNN?Io4Tyyih---~e˰f͚3g`IٮXO[[[O8hVZ7 .䔕@zzÛ׭[7nHLL8qbTT޽{qꄄ7n,\8}O>`0O$K֊,yW_}[O6fիQٳgsrr}] u7n8887ʕ+2+++))СC+Vɓ'/^s5kր(#}322p}ZZZrrkUUյkBۻ~ᇟ{9<0L;vӧϪU^|Eo޼yKoƌ37779r!<<%%%'N onn?~|޽&M; %==e 1=I&ܾ}3))?)SBooOsͲ24|۷>&iȑ~~~ǏߵkWxx ܂:eF_RR/^z+W{Gx~eeetT??aÆdgg?"".\b6[ZZBCCw=vظ4a„o%[)S_xgdd\4+Wl6&&&?u_Kkhhbbb.\ IRQQQbb_~9ei#:޽{ڵ{UA$ɔ_vwwFqٲe=PPP_|+ |'x2 xUXI\YYyALiǎJյ{ݻwL&>%%eرϏ"ο 6EEE$ VZ;_Fc}}}YYy?ܹsBᎎoL]&N8s̸8v͚5K,Zf imm5 \Gdp+,, GvYWW$45k~h>`ʔ)L:09;q~706l`]d61v5uE%&&*Sg977nf<Ǟ7n1ϫT`JR?A=ycǼ***BCC}{Qa eSN}םs:t JI fž5zGӧOaa޽{{4gB1GQWBb_}Unnw}};\]] Jim0SΜ9j4={v֭;.zFW޼y3666$$ &JUA途+WM6(Ba᥆䠠K \[ endstream endobj 308 0 obj << /Type /Annot /Subtype /Link /A 309 0 R /Border [0 0 0] /H /I /Rect [ 500.4120 766.5743 516.6750 776.4950 ] >> endobj 309 0 obj << /Type /Action >> endobj 310 0 obj << /Type /Annot /Subtype /Link /A 311 0 R /Border [0 0 0] /H /I /Rect [ 256.0283 711.4553 272.2912 721.3759 ] >> endobj 311 0 obj << /Type /Action >> endobj 312 0 obj << /Type /Annot /Subtype /Link /A 313 0 R /Border [0 0 0] /H /I /Rect [ 272.2912 711.4553 288.5542 721.3759 ] >> endobj 313 0 obj << /Type /Action >> endobj 314 0 obj << /Type /Annot /Subtype /Link /A 315 0 R /Border [0 0 0] /H /I /Rect [ 497.7503 711.4553 514.0133 721.3759 ] >> endobj 315 0 obj << /Type /Action >> endobj 316 0 obj << /Type /Annot /Subtype /Link /A 317 0 R /Border [0 0 0] /H /I /Rect [ 154.1310 687.6458 164.9730 697.5665 ] >> endobj 317 0 obj << /Type /Action >> endobj 318 0 obj << /Type /Annot /Subtype /Link /A 319 0 R /Border [0 0 0] /H /I /Rect [ 164.9730 687.6458 181.2360 697.5665 ] >> endobj 319 0 obj << /Type /Action >> endobj 320 0 obj << /Type /Annot /Subtype /Link /A 321 0 R /Border [0 0 0] /H /I /Rect [ 172.0223 675.7411 188.2853 685.6617 ] >> endobj 321 0 obj << /Type /Action >> endobj 322 0 obj << /Type /Annot /Subtype /Link /A 323 0 R /Border [0 0 0] /H /I /Rect [ 188.2853 675.7411 204.5483 685.6617 ] >> endobj 323 0 obj << /Type /Action >> endobj 324 0 obj << /Type /XObject /Subtype /Image /Width 22 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 22 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 226>> stream c`0b@|XMb> YsE&qEX\"s.HʝX"<猞Jц TQ{zx@x*q\P;d!'b ps:@eÆ(@r) uS@ ]}CCXx MԹ6< 10AY@@lŴ&X \ jAfXv@CXiJLU([.C endstream endobj 325 0 obj << /Type /XObject /Subtype /Image /Width 22 /Height 18 /SMask 324 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 22 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 18>> stream 8c`` endstream endobj 326 0 obj << /Type /XObject /Subtype /Image /Width 20 /Height 14 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 20 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 135>> stream c`@,L %Yp1DX¹0}!&`TB0*x&&0L+3P3aU tM;vJyGlmNh `9;@<c-/ endstream endobj 327 0 obj << /Type /XObject /Subtype /Image /Width 20 /Height 14 /SMask 326 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 20 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 17>> stream (c``PV endstream endobj 328 0 obj << /Type /Annot /Subtype /Link /A 329 0 R /Border [0 0 0] /H /I /Rect [ 204.5850 662.5601 220.8480 672.4807 ] >> endobj 329 0 obj << /Type /Action >> endobj 330 0 obj << /Type /XObject /Subtype /Image /Width 62 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 62 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 399>> stream 8c`0b ul;7c B*fm &Aɚ3Fx5gMٴƎ c`rH f: Dy\( o &sSsm BǷ\8$@9܉ljG39RUwAFg*~:DP%b& MU, J\9"DY8 4=t$; Q>Ӡ~sHn9%$S pD@( JADzǀQ־$ HYzy10DaCL CB;вYu$I 'TKClŴ&v}JY\l,5t%g:`E+M*"[7JH. endstream endobj 331 0 obj << /Type /XObject /Subtype /Image /Width 62 /Height 18 /SMask 330 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 62 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Oi  & endstream endobj 332 0 obj << /Type /XObject /Subtype /Image /Width 20 /Height 14 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 20 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 147>> stream c````ba6ؔev li`+1.8D'`V@aH[8l!@Y'U`,$37-fj #s`+00(qCτz>8À An6)Q endstream endobj 333 0 obj << /Type /XObject /Subtype /Image /Width 20 /Height 14 /SMask 332 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 20 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 17>> stream (c``PV endstream endobj 334 0 obj << /Type /XObject /Subtype /Image /Width 21 /Height 14 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 21 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 211>> stream c```a&]V3kTjEǜ. BXÊ*= gZ)D>6SZ HSc`PPݱ$z! bI121 QE:P킘 et(XtHP h\XChe U-[)LϾ 5@M2 SZ1@B; endstream endobj 335 0 obj << /Type /XObject /Subtype /Image /Width 21 /Height 14 /SMask 334 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 21 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 17>> stream (c``  endstream endobj 336 0 obj << /Type /Annot /Subtype /Link /A 337 0 R /Border [0 0 0] /H /I /Rect [ 534.5565 630.9316 550.8195 640.8522 ] >> endobj 337 0 obj << /Type /Action >> endobj 338 0 obj << /Type /Annot /Subtype /Link /A 339 0 R /Border [0 0 0] /H /I /Rect [ 93.9735 607.1221 110.2365 617.0427 ] >> endobj 339 0 obj << /Type /Action >> endobj 340 0 obj << /Type /Annot /Subtype /Link /A 341 0 R /Border [0 0 0] /H /I /Rect [ 93.9832 583.3126 110.2463 593.2332 ] >> endobj 341 0 obj << /Type /Action >> endobj 342 0 obj << /Type /Annot /Subtype /Link /A 343 0 R /Border [0 0 0] /H /I /Rect [ 26.2500 526.7558 141.1343 536.6764 ] >> endobj 343 0 obj << /Type /Action /S /URI /URI (http://www.math.clemson.edu/~medlock/other/SwineFluTextS1.pdf) >> endobj 344 0 obj << /Type /Annot /Subtype /Link /A 345 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 395.5267 147.7500 508.0267 ] >> endobj 345 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coverage1220.png) >> endobj 346 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 347 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 346 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16064>> stream xitǕ&zVT Ka'P"(bkYg5ȶ4HOg'α4>}FjҲ([<iv$})(ԚGȈDRyo 3qͥ2cB۴4afs{{پ};9T__fggvyᬬ,544J$DffffŊ---p… yyy###͛7o.,,U2 B'&&gff/LLLfdd*k׮n5::vfKnݚ b)--miiQcxhQQQGGG~~~~~~{{{(zzzJJJl6[8V$c nAq6(pCHL̢ Rq 2Jsss9XIjq.=V9(r5䦦& ggg׮] Na`@ą"Njnn@0T@ojeAVkCCC0裏^oqqH^^4S m5,S=(B#x)pڒS(S/((w,uk]?T9N7; R3P(J[f  pPz>]drzzԛfl2;k9((T… .\ 5/" nD*x_5@`iwi$`5"KJ=z,'[(f߻=R1PvLL&9qÂ-8nsiCq@ kK33]HiQ[k34QhkgK&cM088x…Cq^^lϩ*9$ Kh&F%RJ,&٦PRY(NUN+fwap=ݡa1XgfgfgDڗT% B#:Bx0]wߛ {l&7D$ݻER(rϋjVQ 1N:VsFVFGG$ƸOTUZ')Z*O JB!$%h ͢Vqi'Iː mB@ @*ڸqc~~>ݴiS<okkۼysFFBhʕŢp6bЖE^2:OK@dD1 >T_At?33WO@8'Ճˆa[pw\%H<'E"/4^Cẓr%)t8uuuԈ`bbdžVCa0 ysC/Fi N@qie\$  VqnnnUUUyyv$;/< 8"{P$(A1u'U\6D› Α⬊ *RU :ڎ\@WFt\"I"H$fggl6geeqù/[v; ^3([*(ȍ4!&''].W<}Gx?hw~[>-[ƙH" UUUy(;\oa6uX'|˗o 쥣/pR${D\|X$BraBT@f,_|xxx``@WNE2c`"hk;w&=nlCZh hg[RIB#BpmP$헆[VRjhٸ56@ D۫vrX&zDž="BZV1-SX`٣vi%dVUUXm/H#f^n9#H€A0zt X@.JCC/j* "/Uۄ B}}}֎D k0NY(E;%jQYLjAyd`r{0~! I bǧGiF@o ,CQƀzG%{Hd9:9(FT5立_~W_}:gW=Ur:lp3UZyoP!x  %&Xc!{ 4k6P4-ٔJvŋ$ӧ2ve̖X6ú(A Ccc2ἐ#`v0ںuk<}GFFFFF*** C~Y#ftJvȎhevjl "mVZE+**b`HR&k#MũT;ZC V+W2,A)"!seÎp .x%]j3؄P( Q,UTB9Q=SHLߪ ` .ͤotO^%q'=4 Z`zz`bbBocvGYAi-3̓9z(Ai*ԬrL} '9G*1ke8Ap>Q`/e [D"mggg{DbCYג"2g۲%WKjzPTdB% Ht@ MvW@QK~lmQڳiy`!"r B&/g(0HʼneG@HF:==rJT|b6[1^_B<%o޼`l~pzK}K 914PG`] !7̈~CCC;v8rMaFYIu'S}߿%]jyS+i7W:RJ^z<|0%hŹeE ԅ Hԅʂ1㥥˗/':u5k۷nݺaA믿=8UUd鱍#b'mJ1Ƅ Bloo@@Q/u&IV8. >fF{.[ !TXXINF*=ؑRDJJv=P+^&PdlmmrssP E H'h#E%X,ٹaصkLJŋ-6}BA ق2wT,% 9;e.%~z!K.YVŽ ;dbN-4<IHXąh~2Ldi<`hBp40W$CCE>hD>ܒT,zK5Aў m@Y|9`5S1 I ڱ^D+鈅 t t`׹l֐TD>M(n-iŒE J݃V&.tS Y6i=!\F|P#o8ױ}qݠģ>J 0,QTBX]Ε)}N+*B\p8mDjO*4eW&GA_5N a.)Ggg&S)4bF*F;ލ}2_% @db?l~衇^w|f/NV_-By^p?>iQJ ={ 7{wXg4rR@P0( cv,;r}[oH$D?NJN_J@$YXx [X8_AQ \?uıX'|~Y6K&Pl6]t)sfffARO 7ooll{ꩧjkkkFF85Dr9Q"` E)AnB@O<^Ch4nݺӧOb1ߟL&}dZuuuuuuk׮ep\錌_|qd$d2sssɋY<OQQdF7|30zEZk׮u\b@`vv#J*2yA F=T#9s9'| }e˖Z__ӳfJ#77Y,^z̤Ǝl>oϞ=7|( 7@M$//djjE?''ü3w}wppp.B 9~zӦM"Lin RlJO.%e* %v)ArT$8 ¬O$֭D"1)n{oJVkNNn?tЎ;XolXVZUQQTWW9s>B D2cY]]z~bzv;Ձۊɗ.KP~DL2yXrꫛ6mڶmB`-ql&s,\?w}a&G666?%o4.4HfY -HU5$AB:znp7J"P<>۸q#[x```ӦM.8((bE4:JjJn[ڊ%(PIʜ?{˗6nhXXJ ,1T`ڠrQ04 J@ np7o[~gffbZbqR8-mEAל\*D@Ra46ƸbI 5r7bыF, J.[=dЅ1(TEAI3_HsS-Kk+fPd}2w^ #^b+ LtN, HrR4DM8QH MiM:PTkE7O>$;"OzH?nǛTU;nnw{{n)-- pȑ#+WV5;l%g,T2lkkSe||<++?N$7nlkkX,Pnbbbٲe]]]W|˖-kjjp{{)((PӑHdٲedwsSN)2;;U\\1޿KK yorr;[m۶9Ϊʙ@ PSS366j*r#$.;ZZ$;sR.Dfttr vwwY%~rÆ n{vv6 R꒒rQZZZQQחg6KKKv{QQQ" WU*رd2`0srrJKKڵkE>&cbhlD˞\q. %=9bXGGǪU@柤611A~a1M(RJ|f9;;{bb"Lr#c, b9Kڻ}N( =|fJKKY1i\ӤBsCCիf&iQ?"sLtp)UU5Htww;vĬqI#8߮G8am(CO BBqudL@q!ɣ@ 33sݩTm&MS9' ކa+fzrqAzB 3Mɣ| i=D=ֈ2R(In#(qW fuNKP&i'>m.48@iCQU`/ %-B3܆KևԠ! Ƕ⚋]j^PWj [ܠbq荋J$h E%]V,EGFϤL P-Eez3|cKAX@J:v .ȆBP*rn۠3n5t$" t%|V)[o%pH(۩8GPoM@qJ)!HJO nA=ztddr}[=Or%u_&Iuղe8M(7JC/PW%BR(IYzġc27FA8p`߾},2 m98x?Qvz{EK%HQwʕA[.pޕ-ܪ( Nu'%$2R@ /*f:c % l@VVփ>H˗;N|Vj69w=UQs6ݦɮA=(iq61}eK.wqΝ;\ee%Ƙ~@qz4EGX9+#$Rjb@$Mk[eWUUUWW-a})۫tX/&@K$bt:_z&P\B'Fhc( +9ڼcಞ$`WWAz/%]( }Q(|`cغu[,f#aTQ m-,Ti/,6{1sZjzfnW_RBӂ@}}}mmʕ+I3]z-~W2I-qMf˻v;G1gDž ܬ0| q8,]`JKnzYl[lBP_3όqc?z!H_nb z,;ήO ]7jaXٱ3 (>%xӗnU$=c5"APq64 ~'@TÍn=QqgmM\ЗHi9yCg'TU{׽bF ʊ {نՋdT,vݗΉ "7n%w[P$I4mZմD 6mR5hzZay:SCȑ#C\ax]E/sc4l\hue,#(t4HX P©=j900I/[ ~뛗B-eVM` r Ɣ%566߯t u^*ACl4}as IU3LN5iI[dPdG16,Aػw/{j ;j?g`;|V'R RpM*1 "Ƃ`yy99<44L&< ojgR+Fӿ}z 2싈/_btzXEEEEE%.Ao@+qY΋TUM ִb钅P`crx<9/i /קxJ( [I6EyK2#qs`xn#vPuD_e" R8I'- ̂29RXv-͛nl2tyjJyٛ4B6wn1$lj-j ОTpK ݭ[R/Xڌt^mAJTqN7c@֘5ٶ`-[vĉR:i أ(/Rc) H)C"@ pbp6/kq86>>(J4#nHvJ)XBvʕ+֭4F\$@6SUA+UV{m>@*i< 5|Ēr`JFGy [ul B^ۻ(7\S+& K hpeY"D?cld\,d;9Rq dR?_g,a;z4!&&&N>MmlLo">/l 1xY(ͪRT**UsM946DQ333lC!iAc*ivjN`{k6l@~*:wE A;u/%6a4 _j3O?)B ʛH: ,0"Otj)06't999X^zu}}}hܠ Su1l/'ȑ;cXFPku92%\4/Yxq6_x:qvv1HI31-#}}AvNIBA8Muي1% Ƹ!++)cl2>裂0sZ_&eSs޾p\,I=!*՟nJ 4d+ӂjkkF---}R7`[p% `v 9}r 5QZD,A fsUUƘ!Z/`DBEk?#f%EXGGŋ:ttw<˵{(sp|,OtAnF#<(Ƹ`.7żfOO5 طs3^3K^16-/Fin23233l6- 5B^" uu֤azz&3+v'1*|#.EF>naæYX-[YA | e7CJ`IB Rr7' >;כ„p'ΐ\e `R.\:fP:j ^glT(0,JvjLf=Z)%d]8I<&sX;wu@eeId/B:AM\"a޵'mBȧfg{q:;4.s B.H;RN1Bu FJ6?W_v(ɍ!ݺT*(qC @T*B&)JjRUcXMA  q3q2TU@PA;NT*J$b9V5+Jݶw woϑ }TxfsS$OY  # _|E}W^̬y7bC9q05f]Y\nwn^ѣgQ7̢VJŎ"'d2ÓLDr,38&q0LJqqզMg\vN"!Chn~i7Nd7"3=SΛLYtLB ʲJ<.d**){'H7#(OㅅPfm޼mjQ R) ѿ_,IR,RGpS/D^-W0SHÇ^Ť.\p8߹%EQ~L"xNQիK"իZ__GG!d[8" [(AzTR|agnǏ;NMՙL&EQ@kf67lؠ(Jkk+f=z4//O>!9lmm}ggIEQ>cǎ=zU^GI׉ &IX(T*Eן cQO<`& $@ c2"K>00P__O?Ib E?x6A5i&bk!''!T\\_[[L&ɤjn!dZx>cL+7c9>p@D I oK _&GF$###''~``_W{淪r\+V{>Я~;vѬtovII 744`~_cWQI)..X,g޽+V :9:=♙JD& =UR i^TTB.6N:11nݺ˗/6ʉQo޼9Jf19"#G[5Lk֬Q%Mf j! 'l BHQUU].ׁ;[ !S`E"~zGIQ% =zʕ+O>ba;tAEBs ;P۔^,nAlGTUEtM qC5'U|ԩ 6TTTqG'I:XL3'1nii)++#B4ހIDt㣏>b r)U\J<$BP e-rVvtt466^xq֭_(,2gCҙ&x PTv x Y̒L]HkhBUV!?666\[DGM{aGz*燢ŀ '(C5T2L;w.??=$rYk=J 8KB4K0 Xyĸ8KCXtS2ߦi 6s հ(k+߄7-ZaG?.&DWRC:T*w ^h4kc$' ڪWlPhHSk܄qˑu}GѨ_y]wbx vС{QG-((hjjZr=oQ322;v嬬,|-[/}K͛CPQQQ<O&7nϟߺuk4=wܶm۪~޽u__/v<>{7^*J(,, ^>---ձX쩧я~dTU|W~oo/Z-GMRDmdv@EEE 7ouɤ9z맧[ZZv5<}z֭7thvv6?I "mW 'k?ofgg;;;nݚH$B>pg+;~ٳffa].W^^lVV֡CjkkϞ=KVlN$͢###^78NKJJ,KaaÇs̴477~'@kn! FGG;;;W^]TT B𞞞@ STaa}jjj󳲲L&/--D"DB!Dl6۶mΜ9cZ#H 4L&|n9r[ou\ҥf4'qNj ``zĤ#nFeE!_zPٞLNNr$hmmMR'N;UUJ&\[N:PUujj!TQQz322, qJ"yիdUUmnn^rbٿ5kl{0W|nz뮿~lllϞ=wy|^onnc~444\z&''`rrf鮮ڶ>͖K"]fM<Vĉ 1###˖-%'if@XckleQzjoh>P^0L?~}{oh4:44aÆ+V[vr{@`H>nnn@p`8zɢ/ZҒ'Ntwwu]nXprrrˉ[)lrJKKvu{_rll%X,2>(777 8pŋ^7+++:th .˱Xc峳lUUU###ƋֳD"HVcB(LPXX855u7:NR\\yfL盙q\{MNN~zf3F))) Gپ}{fff$!9^~fb}}}Ddee}zMU57ń`0z[nm/++kΝp8 n;8믿>###777??… v"O(eggoذᮻjnn^jU* B]w]~~j-,,TUu4p"ABE8r^3Yn[vMSx}4ؓ'O*$&iŊMMMf9##EFtR0Z Dn7664IofRe&H#vOOO?~D_l6^;vlΝh> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 226>> stream c`0b@|XMb> YsE&qEX\"s.HʝX"<猞Jц TQ{zx@x*q\P;d!'b ps:@eÆ(@r) uS@ ]}CCXx MԹ6< 10AY@@lŴ&X \ jAfXv@CXiJLU([.C endstream endobj 349 0 obj << /Type /XObject /Subtype /Image /Width 22 /Height 18 /SMask 348 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 22 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 18>> stream 8c`` endstream endobj 350 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 391>> stream 8c`0b p@(mftt,[BH d>(k> Ys) 'S0lQJgbhCTƹ6w!~$,`sI H_s3z**E*P-@ 6m NPLTUHy@bR$-cٯqHq"f]0VA\=t@ǎaC!l)++;ה>(!m9%$SŒ)`@(4,@sIcB׀T@I?KO?&s3lxvbaBZ609ZK0```/SX) D?GV$1!_Ҕ"\ =" endstream endobj 351 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /SMask 350 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om_x \ endstream endobj 352 0 obj << /Type /XObject /Subtype /Image /Width 20 /Height 14 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 20 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 147>> stream c````ba6ؔev li`+1.8D'`V@aH[8l!@Y'U`,$37-fj #s`+00(qCτz>8À An6)Q endstream endobj 353 0 obj << /Type /XObject /Subtype /Image /Width 20 /Height 14 /SMask 352 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 20 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 17>> stream (c``PV endstream endobj 354 0 obj << /Type /Annot /Subtype /Link /A 355 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 186.0817 147.7500 298.5817 ] >> endobj 355 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/impact121720.png) >> endobj 356 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 357 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 356 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16363>> stream xͽyx[y/@b% ($.Ͳ؎Ik[7MK$wI{طu$Mk77vȵ,#[,ɲd-%j ; A$sh08`o~;3gE1L(W_bT*Ol{{/3Ϝ8q//Ye2PJ"Kngff^|ŏ>!$K/XRR}>PA~ҔbT( +[ O"wd8FO3H[n˖-T48^ Es㉌(Jh4F/(ό!˂d*R}蒘yAxLf HbX,>t yRm#n1 …h<W*^/h``@P(T^^>==ͬ;GtR.\쬭ݱcQ1(p Sx"#P-uLԈN@TNsssD xAłA___<yy"bV@+++:N& ⁸V^xF'HDx 'OXP(Izj()aJ`5(DnKU!3ǔ{xqF?Ѻ2A b%|y;n{<ֆn[,f+Z6ٳgVk^^D]jLLpc%O@)@P_hM$;ҵL^BиmAuj~rss{{{?D"q'N~hTEFsPLS B)Ѝ .LLLeͻZE֖\.1Ln{vv9N5%:x:({MMMOO( EԂY\Ӧ"e1ΘLi@Y 3"꺺ZB!B@ N=2E)ATVVFQP`L]D#ӑ, CC vuuMNNb1zUUU^`0+yG@.kfff֭-p&KYxH" qC"ݥ TP(^B@j޸qcjj`0H$JKK4/041H8q… ۷oyXEŲj0xG&Jjl6FFqddv=/|*ܤȻ<%Jwwwvv6QК̢6MӍO*C!ugjnݺD"jV*՝:("!: (dee};ߡd i+^EFQ`0ZO~_755766"U˄<lFG*DQb/^zN*JF.䵞JklE@L磳@1kfHYBܜfZ066pAAA__o "ȕ+WVWWyl4eB@VL f T(L&4RA8 NJ[;Z,J PSS311 T*鬨ti?NfWSFJtP*ëOd!0 !5"K /))67Ёh'J>#jVԧ> -80"ϊP*"~GGR/.Stqnnn<ymۼ^/iTޱR)VLdE"o,/dhkB>'??fݺuɉL.H"mmm=lFNwYI*'wKYuYV4+)FE[K<88S@0lll4.ڙ_ X,>mذU2NA'cI;KKKodeef֎9"ԂIC)p*(*NLLeNk׮:=@Z1OビF!LIP27\&)//OںgbYj!JzRvv~x<܌,֭[8 =dyZxp%CLp'2])(i(^-<(] I=0dggl6ڂ9NEd<+^ U(A(Bexm3#ScS|@ drݫ)!: &y^G 꼕҉X,Ah0 ^WՒ꛾oVUT$KkpppttјTLvJl000099i٪%LrI%.W@(Zn]p8Pj!BBёsv`4_yXn$anV8/^z [m6.]EœqpY89q" F-v:7nȔɓ'].ŋ}>_]]]{{;zn?)X@..=}jD"%QL.r:z?y b,5ϟjllܿ8[%AxBTaEKO"dQ$.W@\#e8;x91칹MMMUUUjvvggg{챕Tr'(4HIʆ\2LPY@TjTCBd;~Jg%9p' "m BDQ|EQt999j-3G kfH F5rD"A!p &%dV*CO {dwP *?R "W-2 GSRi~PkہyI1CCCO<]2faMJUUUhݺu<ώ;B#Lt<B999`0+++ Cj䐠z~Bs4P.bwwrIIZ^n=@0hIf%>[4=x^7 CCC]]]+++_b0,))хT"'&ot _x;v\p LM6ݼynPLYȰDQ|.]7˫Xn&dr{ٳҞe^_E@'(2 z^RMNNkylllppv\}{L/L\.zᇙrD'ɜX,OzӦMfٳUUUjZOx&@ݴizW{J_`;pFW> IS뙤zܩ{~ÁR*+++q 3/(:Bw5-R||A\rG 86(-D2z8YiLVAN≀'Df2yiҦn{Z EPk k0] ǗW2ɬLY On -L e^v:<+ ˉ4sss(}mm]ҁ'2g 3ZyL(jDx'&.^:S/2z\[Bí<ӧϟ? b߾}.RX,v̌j z^...|MP*GN'$dyȑ}k( xuCCCii)-K9ree~aCCC8]]]Dp@)5q-MVLH; &O %-/>ʓPRh:u۷oJ F7!GFFv霘0͈ 5XD8xcǎUVV~3׋pX֕"2liZ K_lF,d2[XXHH+0149|ҥK}Qaaa4Z7oFG]DÓ ϙbvY"XVJ%8zQSYYp8ɤtȗL}3 I*)(..h4 m8ڵK.Qp{{FM&11)Ҷ+ vt/ɜ|-" !k4ű`0XPP0??P(rrrм3qeltiL&U*Uqq1n }5 7l|ƍҖ.g][??ЬT+++PJ;VFQׇ7|z@>֍y ɤ@ӡZwo%o߾ |㍉c6z7+ӭ58XP B+}B Y +zfƦ?k]~LTʣuuuMAvt ("irxj3W"="]Qꔰ])+JZ]\\<99)&"u.*Ԇh*AS~!uΒH|h/pС]B%\SKxAD-aH":|WPk@Ԋq[ *8^2yE1";vlRc>㢢"RvKKK05`euc6io䓑Ēpc,xpǃ̡`08RdO>xmD"͎7exd#2H_?u,HUqqqIIDuu:K$Y4.(FQ֭ 6x  Eii)JBq^+![8ПEAؿ_ #۷oݎf{8CA41h kyyyÆ XgӦMsss T@џ5뺾:o ~ ʏtxއV^{mF -yS0t(C޽"k׮]ȫl: 菘%z 2 %ZQ4$@1DS@iiiNNSO=e'''ʘF IATg  2jdddzzzrr1˛a(#:v]i~~>Z"gsuDbΝh_F'𠚛r|c}>={z{{Z,!]tM ϟX,Ғm=WÇ-5}Ν;^f^RZdX)LNN5z-vrr:/]BFaB>UII477BKwݼS `+|6M]__뇆x≪+WTUU1;aQ'\YYAqhFRQt TTEp)G"tҥFbGTG#_$cg:DNlEuu+WhPf硩AJʋ<+gtG pୈX,VVV&Gϸ%PP+rwcЬT۶mۼy3zM4r$ نV1^*]M3H7 x\ZeI`H%{cju8zebk0\%ʮ nXCC˙}\t: #)e4##]GI?4,w2A˜߿]]lZ6LSSSib#(q`}~ÇH$C" v-x}Z{&''wg4#k.O³[1J#O<ݭ맦~iT"ju;6KPTCbcTLNNƐIp F,V '%c(G%9r9a@gR<~z:fEzqp:[y)feRCiV`tK_khh}vGGGmm-ԉk%-,ek(JlRqp^1[22sbƩ TWWzvrX]#㇏OX`f4ֺQ_yB1kpwy.=r,dspS7# BjM~ǭ]] # ->hlƒ1r|rd܅CdV޻2Sd>1*݌XYdaRۆIOB!X;͞^Y2X`/QY+%~Al d͋\+,jE9 p@";311122gϞ[nY,VPR{04͍hkN >=#Q_yZ}ƍ۷Y᳒3WRo~V=O$q:UUUCCC wTD9 uuı~_:W (P/vXR-[0t8.\xG6nxsO@Q ޼yʜus7dƊ IJOOh2xСCZv|||rrrǎh4www}P$ z4*4#` *FýO𶶶(&IÅ֭vD2"=o.2K إ 1Etvv ~AAA ) b͌vjd@OddK?(CfAG~P&>FIx74@ 0p'`O<>}CWw J;wq *a̎Bt KHaE*1c'0>>~ajzzzddgffҒ!hHT`?Љy1!U]_~vZ#G]2*-v$?)9W3LD"q5j4#bD"Drss'&&t`oýu;9cȚ0Vv1|n4(RDH&F= ۷O|eHDբLɐ',--+TJ2 .!Ytbd\x,7e+sPD2YK̻<t֎T~Wh8li:#pڵk hp8F#6  sϕwttl߾=?S<  X,C(3<#3W\lPHuuuutt^/}>1F'@> 2 `4/_<66 y7xC#3hR=XO %EyA1 eee/^v@LAt&);;н~R;==裏JoϞF^+liiA-%D"a2@ U7^]p-cf\|*nj6;´D3P#<crg 﫯1gGixI 뭷9RJRW*6 e/T K/)}[s`"]y O0R&>ɤ41sZݍA2S@#c~P{j8k-<%J@ ^5'Ҥ%EEAw$tbx anNIpLDpI ES3ҭxA^_SSs֡f=:::>>l0LSsE8-QKKKǛANѱ ƷC_W+[[Zy~@fez0͏<JH>ԩS555֭zNg6[ZZuL(\>4#7!7n8[ln^# GZmyJ۫("zŋkD}A65B KwJ+ _zci?>- JR( E]] Iųg'"T43(&N oJۿ = bc# rJ͟0J%H+3 BNN:y,TUͧ!Q.-_jy`+@rv5" y>H3qI$Dv>X/D0Hxފ c /lyyoVJȽS4q۶| j/| @peŲby2::*`GtrjSng|E2dwcYh(, { SD7VOw--- !;;/,uZqTd2qKZx&1ju;\>q3ītw6RƉ łcNY(A2Ph4*)8S{ȚڧxGXyf,t $˗/[H$RXX VqNСC. j{{{~'Nh׳慌BRF8L9sk_z.\mooqF~~͛ :%}Pnzf\G^~vs^ BOχB!xdd$L޺upppl6oذ5/?Gjܥq_]]NNU^?11!"$I}-8QQbن?tPYYن \.WNNNVVk^(g3PG=p;?SձX }u&J5%"Iho ~H$$w ǹ@ gg_~4khV`0 qUiI>JQ2Wv"UA/*C- 'Z.p8! j2)qb*'V1#T J_Zwf1B@k>,[&=Sz!P%F. q49wK&Cܥt^ĘHP5JԤjm[R!RRBLrTvI΅www H[/RV\-TDQڴiht\y!P|IǘAҥK6M+0I$1CRL&֭[d2 UUUIjX2:2N?}tvvӧQ|ii)`g\1 )Μ9nZKJJ:::^ ~?;` ee&J-}Jv:thpp0;;gOS,..r:ډD"''Z[!HqVD򴆑3<Jg833˝N\NNKR1ƨWsRJFV8`٘_$BD6:رc z8?H Qu:$xm6 և~~$FS1R 딭HIti˘_saJK)#ߴ4h"L0(G*SfdcQS4"K8ò)cFίfr$"(Ը<>r{+pjH/;/䮌Ӯ,q0a,{'qΈ}*VbF&. b&a c!fh y,=B22E#ġ St67`͋~?c}9R/ (n'ޑ!mV`h ˟Dbtկ~e0v޽sN/ 07b%ɃFAS7~"˧iCvv6nRv&Eb`]BWWWJ%&TEYbdx)E R$H$"QńBYz6K&<'/T· EA ->+R G6뫭UTя~TVVh$ᴘ `g;w߶lvud2T*ZPUZDM"?}>,jllyyyEW@ī'0HrJII :sέ_'?IGGL$K.mٲۑH Joqԩi #1A>ݻwONNR^pjk<(ֽ^k^ X@`dyy9 >|nII)cr4UըG%r$F/SNH/ CYYիWEQ,**M'O 0_WWpȑZi`0 yH$'-C՝FR~_<@EEFYYYoooSTp8JJJBzSSS. 2 Q:QixN]k4tr#G`OOO]]]KKZN$N+++ =ݖdT*sssjk V/ "r斕y<ׯ ͛7_~vvh4xNʥVv]R>(h4 ӧOMNN_- ) t:CzQPP<44] Tk;RfC ~}7n |>BQYYܼ477,XJrΝajjѣett477=Bb6$tWEQ744dee;wOOOnڴpDRV;y? =555::j#*.@Ieǎ;=ښ=jfjqq_okkkmmEqllΞF$#3m QJ EyydRT'N)((uuuh){wĉ2\^^Fc8.))LT# v8#G檪*Njq~`0(Jv^  JFS>_ :#??^K&N|nnUJPpo߶%%%֭Co޼P(MR("}jNf .LLLBӉC PSS700֭STjl^6Q*Hln̙rbᨯb^2ݺu`FhJL:Hh`4׭[ @nnnqq j5++c||\444٥%ZfԞqR:H-jRF'''Ct2^^QQf GM&EEEyyyP裏>[XX@[2l0(Q-((;~C=DGii[o588XRRR\\Dz{{/_<;;t:.<@l555*jzzիeee=(e6~o24M0<~x8E퀑S>3xwaz/KTVTT ᧞zb1LDbnغud :._ID2tVQQѵkמ|IAle1ԧN<:mddN!/daFS^^mƄ!//OժTsl  6z=~"chZXyA/vټk.AΜ9sڵd2C!ύFL19@MLLNMM=cyyyƍ===n{߾}YYYJO6::z-ǃ>gD3D?3cҹ,KYYmnn2Lmmm b~~=;;poHq7 A ]PP x FS__oX_xcZ3d:=ϺKu1ͥf>V577wƍ='OVVV&G endstream endobj 358 0 obj << /Type /XObject /Subtype /Image /Width 22 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 22 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 226>> stream c`0b@|XMb> YsE&qEX\"s.HʝX"<猞Jц TQ{zx@x*q\P;d!'b ps:@eÆ(@r) uS@ ]}CCXx MԹ6< 10AY@@lŴ&X \ jAfXv@CXiJLU([.C endstream endobj 359 0 obj << /Type /XObject /Subtype /Image /Width 22 /Height 18 /SMask 358 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 22 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 18>> stream 8c`` endstream endobj 360 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 391>> stream 8c`0b p@(mftt,[BH d>(k> Ys) 'S0lQJgbhCTƹ6w!~$,`sI H_s3z**E*P-@ 6m NPLTUHy@bR$-cٯqHq"f]0VA\=t@ǎaC!l)++;ה>(!m9%$SŒ)`@(4,@sIcB׀T@I?KO?&s3lxvbaBZ609ZK0```/SX) D?GV$1!_Ҕ"\ =" endstream endobj 361 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /SMask 360 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om_x \ endstream endobj 362 0 obj << /Type /Annot /Subtype /Link /A 363 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 4.1092 147.7500 116.6092 ] >> endobj 363 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coveragedeaths12.png) >> endobj 364 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 365 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 364 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16141>> stream xŽyXTG>~i6Y7TAQQD5AFQ3&љ$QI$fFEjD%FEA7٥١Vսݚ̯~uԩsowWN{W7ol6f /_o>3{$I$3UD˿$3@ڼ["4~ԩ ,~zxxU|cǎ18BJSJUCD`O˗/Wlْe˖4GS<%u(''# h.] ,$IС̱@0gNflXҖD?88РA8p̙3a4;21̪mҊPZ9f="3dȐe˖ƾ} FB#0MyP^x K`(tyƦB45 Ι3FFF@~~> E[Jե膴 Ǘ𻻻OG:z(5 %셊APѨhN<4@ȏɻ]tgh%yyNʇVj )D=P۷o߼ysԩ 3a L9xCQbg!ų(1M(>*AirssϞ=D)/(Kp@4 S*(JPBpA򥎙@6h uww?9j(懰0b"fQT/1=ięL|h(^'u<@<iPQF MʽC1CEX)IA\"PJͅS26gۄRaruu /]~z^ڵnFeZeV)_t|Iww_~I]՞FbB3 աKD^x$I6ltE!N(mHHȝ;wZ[[͛{UXXsκsι<M *rcYxggȑ#OcǼMLﱓ5cWA!'O +V466롇 O40X`Z a5eʔk׮͛73f9rd}}S/L&G<.0E3gN}}=;wܹsP9[&<4ŋ㰰0}ڄ JPLӧϻヒdIFf!u(mMMW\ $MIkPE zD{ p RYLP6"?!7iI|\TTk.߳>HkǏQ Im[[[DDD޽EݾGAT9[)+[(~<E Hka+Vprr"Zhߢ%Vڇzh=p[dy,Dǹ3 @{P꘼RMFFs=wi>n[DT@]Id)<ߐQ'|3VjFfuGNwvv:L mFQhˁ &!.$gENk-CQ_$)V|{1#NL8>!Oe0,8"A3a!+lƍnޮ7mDHt7@r "ŠΝ;`25!% IV|>q$$$TTT D%kW$YF(Ed4d9ݼysfffnnnBBByyh>åǏy&$%%8q8$}E*B(f;vxΝǏ P 57-}m"Bٳg><*|u Lg10{옘̟?| rWU LN8u(R9rHs644̟?e+,Ï1 $IZ///NrJ,dr9&&( 7 ƂS{%&tpVh1"\ _8q"[{B"d-3r@YPP?/ !TxIHQ_֖_7 |E&ZHwryy:6\SFDDL6 +A|La9Z+"c㛌f1V]e !ȧ8BȖvV毇ש]`@)L4ͩ8_NR,efh g$?ƴǀj?(zͰ4LJ؄BiϘ@*q2dMtREcң'OYBX1UTK'Nc|z2"Lp*2hzޞ4cTFcz8T&ҭBC8JP zy)5)O 1%AF s ҮZjժUJ QqR>j{24F#}YO|;P]<m%f$QJ@iI0Z:TOT K$ 'jvA9A0W*pԡ5%Ɏϟ􅘘___+.F2,UuѬRA%g*eB !H 1:Dxf^%PyT̙3p[CKh05<[7B(ERIrEǚ2JA J$ !TZZ~$2-US2~@MڞpСbE,Zf$I}]cc#+r\Y"kBRuVN7x};wR*Zm̙;ꢠ Iյ^ԌcO>=>>o߾_u|||RRz0hLZ{gVVD].k#>|ѣGwvv,Y$--Æ <ɉVT >Sj+ڹs'/fZ[[  &/(`fU&2jkkku:ɓ׭[B/+V^T6OfϞ} ,ZA^\z>碔mFjC;fa_Aؓ'K=@isfDV$cPNTEFJC${yyyRR݃Gp1LțQXFFG]~}GGW\Eg8+A Gȑ#$]ɓ >1:o TFu1cƬ]#00p߾}UUUL߄ /9rrr wަ&g3wz0Ç۷A|||f̘A84DWN!!??ƍ!!!z~ɒ%3fw.J̕`BKd2~'|Ԩ)t'}E=lFR0ϛ@9vXTTT߾}洌P}e7T?>y26ЎlJyU"&t{R0y&"\TДVu#m4NJ3^ *LSP3y}l)Ғs*PH|YEP% BLPV*PwygԨQxk?Y򌍀uҌ$"a.рt+u(!tB2©#Qæ:' *&0ҜvpV O.|P"b*P 8ƘF^9L&999>2 <4?fJ*ɓ~^߸qÇjZ).* ͜<[oWr2wر:[|͹nJII@ៈ*("NA\XhM2B1aONN.//߱c;<@@>|꧟~*++۹s'~r{n? %*P&;;;,, Td2899/X.]Ti A]h&!WK&B+ aaaxcgx_8f$Ӫwً- 0-...<<8 =XK(N0p|kl2?lAU"DT|R|||BBB؄é?p;v !C7tuu[(~2dtuuu\ww7)ZˋOH* 0,J]RBfb"9oh87rW^@ !Pڶe˖)I_ڇMzU>(L^Jջ]ӗPUW/fJCz T~ _S '=P<P޼yoc h7xOWJMA>4 `R /B(h08 ֯>_+(g(^T(?8,VuUrmF\saޕ2E<Kd3Fu9NwZ-JS0h&S?aiܻj -=yy;6ꫯ:;;d;#; (q[ڵd2ڵ zhhhhz^ԫ4߷nB},|n*uJ񩭭%9-[L&SttΝ;M&Ӽy `Ϥ0EN.&Y+]񁶡aŊO>իi~\A ?z&J) 9.4c̳b+pPL*Azı7pv0 U\0ԇ޾f{;*33mwwwCCCֶ; &څiɰMc((adx =|$h?clū?bI~gݽgcU#-@"lHLF[ڵkG$ʕ+nݢȨ2D7ys(A5B_uMM B(99VnPVJ@~*oʭ[gff>cl7AZ8Bz~ gώ( ӵ*bD&55ʕ+ʶmrND.]]]ǏgjvM|2W :ٹ_~...uuu#U\w/bf!P} b./d@f.́bK,B_fT+] %VL|h[(ѣCBBZƔɱIsfHF$,b-!GVnL8$fd ?2$"1>TNh*'(?Lxg"(͸ ]C1e XBc_gaF z~TPPTU_h8|jme(fweS]OgE !"cV&iCpH(KL.CTUU) 6PhSRR:7enNޣ%B%ef~ ?f=ҍm_Wk{ 'If!hLqs[Aէ `݂f688xڴiG~衇$Iə;wu:ܹcUHdZj"J"dmhh:u]\\GKVԧarVKKKRX|@jo(WS2(?e'={v¶msȑB)49z^J p͛7FFFo_RXx 8\Z!r}lvR_TT)-B [WWd-ڋ3 lUѱ?TaY KJJ0?77*^_QQ?\ IKgI= z#L"h(rYVVHBBBҰ.Y ocb[`2$me"9 *..޼y{fؙQvJ(=74} 6333..nݺu'ニ@y3Iw+K cǡ_|"##=&!W29.x;kp]JPNwƍۭ:ߞOy +zWS,L_THbK]߂|Ѿ[o0( OA#+]b*4:BlJI&+b#/LΝkyb?M6ڵf55 I US_L6 JvS*쁒-H|%Ii$VDIT%//HYiT]]}o*V;/߳f.͙K-*𹿝q=BOJS<5kɿ -@ {(QH&!EHB o4 =S-CIٗ11P4E94a߀|ӦM[of#oS~eɒA'}(gP 7CzAaf\RJ3o<&(i*13bf9UT(ࣟc)A!%,*SGԧx{{  !wuwwggg?<>W7Dt+ Kߧ {¸ïJP²m۶>HINDOzxxׯlٲsԨQhР6F;ydYP/s"%(FFs,XۧOI&b+ ;Ez-uV<*))ٲe˴i}Q&d] > ZSnFRI.L󋋋c&ۖ8;:M# EW Œ! G ۧg];q(u1,%%G.__ң"M|H+4+10PhVmBi 4/]7M(tI?}$$ n @/B(KYYpg90<]`=/nL(S |,Wz"PANnR{ u0W(لUlJ[ZZZ]]hTylKٮ:yZ7hTԣ_BYC{ Ƿ𮄅:AG XPq$1;jYCi_>vXU{)3Z+)W  GʉN $! M; x6dw0BsK{ H^׬}fGpΚ5Ϗ7kB*[}]pU/*CeVfzy$cBj!񍍍}ݵkSO=S/B;b>(Muv0[ˍiKC]x1---''gɒ%0KxmCJt:6B(gTTԐ!C0\@@Nkmm4i޽{ 1T)tUaa%k1!j6fLTa?,f $OMbG{\ `M8jI6 ORXX p?w/phAA||B$$3 EJ[ZZZYYںh"x׉Ă =*IRjj^y ꣢ DwM6შ(<g(mf+ gNIC }>b?#Dԛ?G tBAy)>^x100p T3*Y$B% IR~ggxXX; "qS',9$BSh(!gDR`IB`f"rPɓ''&&=z4,, i{BM`0!p4L2yy?@7I4%i(.L0}A^@8LJu(mGGݻJ+lz/!zH@7@+%Yy'6IGHhQo,%dX)a nښ um!™ `"^zM:&;&؊]hcccsF//7$! tΫ=]ΊP h___p,77wݺuG}-;B*e"!%b<@ 6lP\\?VVV=zT8*}x'|RTTqƼR,;ISJګBo}TYxqqYrpgj>%~~}BH ...mmmq}}}GGGmmmSSSVVec1dz+=\4tF8ouu5B֭[!άk!P.aFOA4;յeqKKecgqZ.?%y&3#Ic=BB(I޸qc̘11͛7!ݳf"A؁ Α#BsFfؙwߙL&GGzBF6:5՗?@/Wك2Guvv>s Db(F1SZP=@/I2dVڢ7nlڴiݺu!Vo0CDwMHT8IMΨ2FKqq9HWǫJ [,<z8Jvƍ7nyqoOFz-F|d|CS9")AqM_Q*H+9_68 b&-`&SK-𚎖ElnGN͆[]p~^셺{R=PS)@;@@$#dPZ^ḔFl;6MlDX1JGy7ˁZd`QXl?`cbQn)pЛ}9~<-:wi/~IZ&%j}DXmePS mmmoߖ$6w3]%$ɘ^= zV%k*I'N9s.**GZ66^ 鍝f{C :u~g}ݯZQQ.JPt)}t:R3@aJJWalGϏk-(F\z3^zi r_}t}v -(/O0޸ѱ1`zon$)??_w*oTؽKz𓛛/?ۃSO%Fs)0L.]2L&i…˗/f%|;'ɲ.D577fsccY^kjjI6H+* N㺺N*:`0IѨ"K]]]GG]c6$Êƿ"%??Cݺu4lnn;6442TWWwwwӕ]]]555Q !6;9 !݆)'O|O>[sYY-bŊg}Ν;9ܕ+WnڴLLLݺu+cP~fsBB»ヒ)K٫W~iׯ۷z7~gW\YdO?D+ڶm[@@/BGhYo߾'VJNN?Io4Tyyih---~e˰f͚3g`IٮXO[[[O8hVZ7 .䔕@zzÛ׭[7nHLL8qbTT޽{qꄄ7n,\8}O>`0O$K֊,yW_}[O6fիQٳgsrr}] u7n8887ʕ+2+++))СC+Vɓ'/^s5kր(#}322p}ZZZrrkUUյkBۻ~ᇟ{9<0L;vӧϪU^|Eo޼yKoƌ37779r!<<%%%'N onn?~|޽&M; %==e 1=I&ܾ}3))?)SBooOsͲ24|۷>&iȑ~~~ǏߵkWxx ܂:eF_RR/^z+W{Gx~eeetT??aÆdgg?"".\b6[ZZBCCw=vظ4a„o%[)S_xgdd\4+Wl6&&&?u_Kkhhbbb.\ IRQQQbb_~9ei#:޽{ڵ{UA$ɔ_vwwFqٲe=PPP_|+ |'x2 xUXI\YYyALiǎJյ{ݻwL&>%%eرϏ"ο 6EEE$ VZ;_Fc}}}YYy?ܹsBᎎoL]&N8s̸8v͚5K,Zf imm5 \Gdp+,, GvYWW$45k~h>`ʔ)L:09;q~706l`]d61v5uE%&&*Sg977nf<Ǟ7n1ϫT`JR?A=ycǼ***BCC}{Qa eSN}םs:t JI fž5zGӧOaa޽{{4gB1GQWBb_}Unnw}};\]] Jim0SΜ9j4={v֭;.zFW޼y3666$$ &JUA途+WM6(Ba᥆䠠K \[ endstream endobj 366 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 367 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 366 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16064>> stream xitǕ&zVT Ka'P"(bkYg5ȶ4HOg'α4>}FjҲ([<iv$})(ԚGȈDRyo 3qͥ2cB۴4afs{{پ};9T__fggvyᬬ,544J$DffffŊ---p… yyy###͛7o.,,U2 B'&&gff/LLLfdd*k׮n5::vfKnݚ b)--miiQcxhQQQGGG~~~~~~{{{(zzzJJJl6[8V$c nAq6(pCHL̢ Rq 2Jsss9XIjq.=V9(r5䦦& ggg׮] Na`@ą"Njnn@0T@ojeAVkCCC0裏^oqqH^^4S m5,S=(B#x)pڒS(S/((w,uk]?T9N7; R3P(J[f  pPz>]drzzԛfl2;k9((T… .\ 5/" nD*x_5@`iwi$`5"KJ=z,'[(f߻=R1PvLL&9qÂ-8nsiCq@ kK33]HiQ[k34QhkgK&cM088x…Cq^^lϩ*9$ Kh&F%RJ,&٦PRY(NUN+fwap=ݡa1XgfgfgDڗT% B#:Bx0]wߛ {l&7D$ݻER(rϋjVQ 1N:VsFVFGG$ƸOTUZ')Z*O JB!$%h ͢Vqi'Iː mB@ @*ڸqc~~>ݴiS<okkۼysFFBhʕŢp6bЖE^2:OK@dD1 >T_At?33WO@8'Ճˆa[pw\%H<'E"/4^Cẓr%)t8uuuԈ`bbdžVCa0 ysC/Fi N@qie\$  VqnnnUUUyyv$;/< 8"{P$(A1u'U\6D› Α⬊ *RU :ڎ\@WFt\"I"H$fggl6geeqù/[v; ^3([*(ȍ4!&''].W<}Gx?hw~[>-[ƙH" UUUy(;\oa6uX'|˗o 쥣/pR${D\|X$BraBT@f,_|xxx``@WNE2c`"hk;w&=nlCZh hg[RIB#BpmP$헆[VRjhٸ56@ D۫vrX&zDž="BZV1-SX`٣vi%dVUUXm/H#f^n9#H€A0zt X@.JCC/j* "/Uۄ B}}}֎D k0NY(E;%jQYLjAyd`r{0~! I bǧGiF@o ,CQƀzG%{Hd9:9(FT5立_~W_}:gW=Ur:lp3UZyoP!x  %&Xc!{ 4k6P4-ٔJvŋ$ӧ2ve̖X6ú(A Ccc2ἐ#`v0ںuk<}GFFFFF*** C~Y#ftJvȎhevjl "mVZE+**b`HR&k#MũT;ZC V+W2,A)"!seÎp .x%]j3؄P( Q,UTB9Q=SHLߪ ` .ͤotO^%q'=4 Z`zz`bbBocvGYAi-3̓9z(Ai*ԬrL} '9G*1ke8Ap>Q`/e [D"mggg{DbCYג"2g۲%WKjzPTdB% Ht@ MvW@QK~lmQڳiy`!"r B&/g(0HʼneG@HF:==rJT|b6[1^_B<%o޼`l~pzK}K 914PG`] !7̈~CCC;v8rMaFYIu'S}߿%]jyS+i7W:RJ^z<|0%hŹeE ԅ Hԅʂ1㥥˗/':u5k۷nݺaA믿=8UUd鱍#b'mJ1Ƅ Bloo@@Q/u&IV8. >fF{.[ !TXXINF*=ؑRDJJv=P+^&PdlmmrssP E H'h#E%X,ٹaصkLJŋ-6}BA ق2wT,% 9;e.%~z!K.YVŽ ;dbN-4<IHXąh~2Ldi<`hBp40W$CCE>hD>ܒT,zK5Aў m@Y|9`5S1 I ڱ^D+鈅 t t`׹l֐TD>M(n-iŒE J݃V&.tS Y6i=!\F|P#o8ױ}qݠģ>J 0,QTBX]Ε)}N+*B\p8mDjO*4eW&GA_5N a.)Ggg&S)4bF*F;ލ}2_% @db?l~衇^w|f/NV_-By^p?>iQJ ={ 7{wXg4rR@P0( cv,;r}[oH$D?NJN_J@$YXx [X8_AQ \?uıX'|~Y6K&Pl6]t)sfffARO 7ooll{ꩧjkkkFF85Dr9Q"` E)AnB@O<^Ch4nݺӧOb1ߟL&}dZuuuuuuk׮ep\錌_|qd$d2sssɋY<OQQdF7|30zEZk׮u\b@`vv#J*2yA F=T#9s9'| }e˖Z__ӳfJ#77Y,^z̤Ǝl>oϞ=7|( 7@M$//djjE?''ü3w}wppp.B 9~zӦM"Lin RlJO.%e* %v)ArT$8 ¬O$֭D"1)n{oJVkNNn?tЎ;XolXVZUQQTWW9s>B D2cY]]z~bzv;Ձۊɗ.KP~DL2yXrꫛ6mڶmB`-ql&s,\?w}a&G666?%o4.4HfY -HU5$AB:znp7J"P<>۸q#[x```ӦM.8((bE4:JjJn[ڊ%(PIʜ?{˗6nhXXJ ,1T`ڠrQ04 J@ np7o[~gffbZbqR8-mEAל\*D@Ra46ƸbI 5r7bыF, J.[=dЅ1(TEAI3_HsS-Kk+fPd}2w^ #^b+ LtN, HrR4DM8QH MiM:PTkE7O>$;"OzH?nǛTU;nnw{{n)-- pȑ#+WV5;l%g,T2lkkSe||<++?N$7nlkkX,Pnbbbٲe]]]W|˖-kjjp{{)((PӑHdٲedwsSN)2;;U\\1޿KK yorr;[m۶9Ϊʙ@ PSS366j*r#$.;ZZ$;sR.Dfttr vwwY%~rÆ n{vv6 R꒒rQZZZQQחg6KKKv{QQQ" WU*رd2`0srrJKKڵkE>&cbhlD˞\q. %=9bXGGǪU@柤611A~a1M(RJ|f9;;{bb"Lr#c, b9Kڻ}N( =|fJKKY1i\ӤBsCCիf&iQ?"sLtp)UU5Htww;vĬqI#8߮G8am(CO BBqudL@q!ɣ@ 33sݩTm&MS9' ކa+fzrqAzB 3Mɣ| i=D=ֈ2R(In#(qW fuNKP&i'>m.48@iCQU`/ %-B3܆KևԠ! Ƕ⚋]j^PWj [ܠbq荋J$h E%]V,EGFϤL P-Eez3|cKAX@J:v .ȆBP*rn۠3n5t$" t%|V)[o%pH(۩8GPoM@qJ)!HJO nA=ztddr}[=Or%u_&Iuղe8M(7JC/PW%BR(IYzġc27FA8p`߾},2 m98x?Qvz{EK%HQwʕA[.pޕ-ܪ( Nu'%$2R@ /*f:c % l@VVփ>H˗;N|Vj69w=UQs6ݦɮA=(iq61}eK.wqΝ;\ee%Ƙ~@qz4EGX9+#$Rjb@$Mk[eWUUUWW-a})۫tX/&@K$bt:_z&P\B'Fhc( +9ڼcಞ$`WWAz/%]( }Q(|`cغu[,f#aTQ m-,Ti/,6{1sZjzfnW_RBӂ@}}}mmʕ+I3]z-~W2I-qMf˻v;G1gDž ܬ0| q8,]`JKnzYl[lBP_3όqc?z!H_nb z,;ήO ]7jaXٱ3 (>%xӗnU$=c5"APq64 ~'@TÍn=QqgmM\ЗHi9yCg'TU{׽bF ʊ {نՋdT,vݗΉ "7n%w[P$I4mZմD 6mR5hzZay:SCȑ#C\ax]E/sc4l\hue,#(t4HX P©=j900I/[ ~뛗B-eVM` r Ɣ%566߯t u^*ACl4}as IU3LN5iI[dPdG16,Aػw/{j ;j?g`;|V'R RpM*1 "Ƃ`yy99<44L&< ojgR+Fӿ}z 2싈/_btzXEEEEE%.Ao@+qY΋TUM ִb钅P`crx<9/i /קxJ( [I6EyK2#qs`xn#vPuD_e" R8I'- ̂29RXv-͛nl2tyjJyٛ4B6wn1$lj-j ОTpK ݭ[R/Xڌt^mAJTqN7c@֘5ٶ`-[vĉR:i أ(/Rc) H)C"@ pbp6/kq86>>(J4#nHvJ)XBvʕ+֭4F\$@6SUA+UV{m>@*i< 5|Ēr`JFGy [ul B^ۻ(7\S+& K hpeY"D?cld\,d;9Rq dR?_g,a;z4!&&&N>MmlLo">/l 1xY(ͪRT**UsM946DQ333lC!iAc*ivjN`{k6l@~*:wE A;u/%6a4 _j3O?)B ʛH: ,0"Otj)06't999X^zu}}}hܠ Su1l/'ȑ;cXFPku92%\4/Yxq6_x:qvv1HI31-#}}AvNIBA8Muي1% Ƹ!++)cl2>裂0sZ_&eSs޾p\,I=!*՟nJ 4d+ӂjkkF---}R7`[p% `v 9}r 5QZD,A fsUUƘ!Z/`DBEk?#f%EXGGŋ:ttw<˵{(sp|,OtAnF#<(Ƹ`.7żfOO5 طs3^3K^16-/Fin23233l6- 5B^" uu֤azz&3+v'1*|#.EF>naæYX-[YA | e7CJ`IB Rr7' >;כ„p'ΐ\e `R.\:fP:j ^glT(0,JvjLf=Z)%d]8I<&sX;wu@eeId/B:AM\"a޵'mBȧfg{q:;4.s B.H;RN1Bu FJ6?W_v(ɍ!ݺT*(qC @T*B&)JjRUcXMA  q3q2TU@PA;NT*J$b9V5+Jݶw woϑ }TxfsS$OY  # _|E}W^̬y7bC9q05f]Y\nwn^ѣgQ7̢VJŎ"'d2ÓLDr,38&q0LJqqզMg\vN"!Chn~i7Nd7"3=SΛLYtLB ʲJ<.d**){'H7#(OㅅPfm޼mjQ R) ѿ_,IR,RGpS/D^-W0SHÇ^Ť.\p8߹%EQ~L"xNQիK"իZ__GG!d[8" [(AzTR|agnǏ;NMՙL&EQ@kf67lؠ(Jkk+f=z4//O>!9lmm}ggIEQ>cǎ=zU^GI׉ &IX(T*Eן cQO<`& $@ c2"K>00P__O?Ib E?x6A5i&bk!''!T\\_[[L&ɤjn!dZx>cL+7c9>p@D I oK _&GF$###''~``_W{淪r\+V{>Я~;vѬtovII 744`~_cWQI)..X,g޽+V :9:=♙JD& =UR i^TTB.6N:11nݺ˗/6ʉQo޼9Jf19"#G[5Lk֬Q%Mf j! 'l BHQUU].ׁ;[ !S`E"~zGIQ% =zʕ+O>ba;tAEBs ;P۔^,nAlGTUEtM qC5'U|ԩ 6TTTqG'I:XL3'1nii)++#B4ހIDt㣏>b r)U\J<$BP e-rVvtt466^xq֭_(,2gCҙ&x PTv x Y̒L]HkhBUV!?666\[DGM{aGz*燢ŀ '(C5T2L;w.??=$rYk=J 8KB4K0 Xyĸ8KCXtS2ߦi 6s հ(k+߄7-ZaG?.&DWRC:T*w ^h4kc$' ڪWlPhHSk܄qˑu}GѨ_y]wbx vС{QG-((hjjZr=oQ322;v嬬,|-[/}K͛CPQQQ<O&7nϟߺuk4=wܶm۪~޽u__/v<>{7^*J(,, ^>---ձX쩧я~dTU|W~oo/Z-GMRDmdv@EEE 7ouɤ9z맧[ZZv5<}z֭7thvv6?I "mW 'k?ofgg;;;nݚH$B>pg+;~ٳffa].W^^lVV֡CjkkϞ=KVlN$͢###^78NKJJ,KaaÇs̴477~'@kn! FGG;;;W^]TT B𞞞@ STaa}jjj󳲲L&/--D"DB!Dl6۶mΜ9cZ#H 4L&|n9r[ou\ҥf4'qNj ``zĤ#nFeE!_zPٞLNNr$hmmMR'N;UUJ&\[N:PUujj!TQQz322, qJ"yիdUUmnn^rbٿ5kl{0W|nz뮿~lllϞ=wy|^onnc~444\z&''`rrf鮮ڶ>͖K"]fM<Vĉ 1###˖-%'if@XckleQzjoh>P^0L?~}{oh4:44aÆ+V[vr{@`H>nnn@p`8zɢ/ZҒ'Ntwwu]nXprrrˉ[)lrJKKvu{_rll%X,2>(777 8pŋ^7+++:th .˱Xc峳lUUU###ƋֳD"HVcB(LPXX855u7:NR\\yfL盙q\{MNN~zf3F))) Gپ}{fff$!9^~fb}}}Ddee}zMU57ń`0z[nm/++kΝp8 n;8믿>###777??… v"O(eggoذᮻjnn^jU* B]w]~~j-,,TUu4p"ABE8r^3Yn[vMSx}4ؓ'O*$&iŊMMMf9##EFtR0Z Dn7664IofRe&H#vOOO?~D_l6^;vlΝh> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 369 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 368 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16363>> stream xͽyx[y/@b% ($.Ͳ؎Ik[7MK$wI{طu$Mk77vȵ,#[,ɲd-%j ; A$sh08`o~;3gE1L(W_bT*Ol{{/3Ϝ8q//Ye2PJ"Kngff^|ŏ>!$K/XRR}>PA~ҔbT( +[ O"wd8FO3H[n˖-T48^ Es㉌(Jh4F/(ό!˂d*R}蒘yAxLf HbX,>t yRm#n1 …h<W*^/h``@P(T^^>==ͬ;GtR.\쬭ݱcQ1(p Sx"#P-uLԈN@TNsssD xAłA___<yy"bV@+++:N& ⁸V^xF'HDx 'OXP(Izj()aJ`5(DnKU!3ǔ{xqF?Ѻ2A b%|y;n{<ֆn[,f+Z6ٳgVk^^D]jLLpc%O@)@P_hM$;ҵL^BиmAuj~rss{{{?D"q'N~hTEFsPLS B)Ѝ .LLLeͻZE֖\.1Ln{vv9N5%:x:({MMMOO( EԂY\Ӧ"e1ΘLi@Y 3"꺺ZB!B@ N=2E)ATVVFQP`L]D#ӑ, CC vuuMNNb1zUUU^`0+yG@.kfff֭-p&KYxH" qC"ݥ TP(^B@j޸qcjj`0H$JKK4/041H8q… ۷oyXEŲj0xG&Jjl6FFqddv=/|*ܤȻ<%Jwwwvv6QК̢6MӍO*C!ugjnݺD"jV*՝:("!: (dee};ߡd i+^EFQ`0ZO~_755766"U˄<lFG*DQb/^zN*JF.䵞JklE@L磳@1kfHYBܜfZ066pAAA__o "ȕ+WVWWyl4eB@VL f T(L&4RA8 NJ[;Z,J PSS311 T*鬨ti?NfWSFJtP*ëOd!0 !5"K /))67Ёh'J>#jVԧ> -80"ϊP*"~GGR/.Stqnnn<ymۼ^/iTޱR)VLdE"o,/dhkB>'??fݺuɉL.H"mmm=lFNwYI*'wKYuYV4+)FE[K<88S@0lll4.ڙ_ X,>mذU2NA'cI;KKKodeef֎9"ԂIC)p*(*NLLeNk׮:=@Z1OビF!LIP27\&)//OںgbYj!JzRvv~x<܌,֭[8 =dyZxp%CLp'2])(i(^-<(] I=0dggl6ڂ9NEd<+^ U(A(Bexm3#ScS|@ drݫ)!: &y^G 꼕҉X,Ah0 ^WՒ꛾oVUT$KkpppttјTLvJl000099i٪%LrI%.W@(Zn]p8Pj!BBёsv`4_yXn$anV8/^z [m6.]EœqpY89q" F-v:7nȔɓ'].ŋ}>_]]]{{;zn?)X@..=}jD"%QL.r:z?y b,5ϟjllܿ8[%AxBTaEKO"dQ$.W@\#e8;x91칹MMMUUUjvvggg{챕Tr'(4HIʆ\2LPY@TjTCBd;~Jg%9p' "m BDQ|EQt999j-3G kfH F5rD"A!p &%dV*CO {dwP *?R "W-2 GSRi~PkہyI1CCCO<]2faMJUUUhݺu<ώ;B#Lt<B999`0+++ Cj䐠z~Bs4P.bwwrIIZ^n=@0hIf%>[4=x^7 CCC]]]+++_b0,))хT"'&ot _x;v\p LM6ݼynPLYȰDQ|.]7˫Xn&dr{ٳҞe^_E@'(2 z^RMNNkylllppv\}{L/L\.zᇙrD'ɜX,OzӦMfٳUUUjZOx&@ݴizW{J_`;pFW> IS뙤zܩ{~ÁR*+++q 3/(:Bw5-R||A\rG 86(-D2z8YiLVAN≀'Df2yiҦn{Z EPk k0] ǗW2ɬLY On -L e^v:<+ ˉ4sss(}mm]ҁ'2g 3ZyL(jDx'&.^:S/2z\[Bí<ӧϟ? b߾}.RX,v̌j z^...|MP*GN'$dyȑ}k( xuCCCii)-K9ree~aCCC8]]]Dp@)5q-MVLH; &O %-/>ʓPRh:u۷oJ F7!GFFv霘0͈ 5XD8xcǎUVV~3׋pX֕"2liZ K_lF,d2[XXHH+0149|ҥK}Qaaa4Z7oFG]DÓ ϙbvY"XVJ%8zQSYYp8ɤtȗL}3 I*)(..h4 m8ڵK.Qp{{FM&11)Ҷ+ vt/ɜ|-" !k4ű`0XPP0??P(rrrм3qeltiL&U*Uqq1n }5 7l|ƍҖ.g][??ЬT+++PJ;VFQׇ7|z@>֍y ɤ@ӡZwo%o߾ |㍉c6z7+ӭ58XP B+}B Y +zfƦ?k]~LTʣuuuMAvt ("irxj3W"="]Qꔰ])+JZ]\\<99)&"u.*Ԇh*AS~!uΒH|h/pС]B%\SKxAD-aH":|WPk@Ԋq[ *8^2yE1";vlRc>㢢"RvKKK05`euc6io䓑Ēpc,xpǃ̡`08RdO>xmD"͎7exd#2H_?u,HUqqqIIDuu:K$Y4.(FQ֭ 6x  Eii)JBq^+![8ПEAؿ_ #۷oݎf{8CA41h kyyyÆ XgӦMsss T@џ5뺾:o ~ ʏtxއV^{mF -yS0t(C޽"k׮]ȫl: 菘%z 2 %ZQ4$@1DS@iiiNNSO=e'''ʘF IATg  2jdddzzzrr1˛a(#:v]i~~>Z"gsuDbΝh_F'𠚛r|c}>={z{{Z,!]tM ϟX,Ғm=WÇ-5}Ν;^f^RZdX)LNN5z-vrr:/]BFaB>UII477BKwݼS `+|6M]__뇆x≪+WTUU1;aQ'\YYAqhFRQt TTEp)G"tҥFbGTG#_$cg:DNlEuu+WhPf硩AJʋ<+gtG pୈX,VVV&Gϸ%PP+rwcЬT۶mۼy3zM4r$ نV1^*]M3H7 x\ZeI`H%{cju8zebk0\%ʮ nXCC˙}\t: #)e4##]GI?4,w2A˜߿]]lZ6LSSSib#(q`}~ÇH$C" v-x}Z{&''wg4#k.O³[1J#O<ݭ맦~iT"ju;6KPTCbcTLNNƐIp F,V '%c(G%9r9a@gR<~z:fEzqp:[y)feRCiV`tK_khh}vGGGmm-ԉk%-,ek(JlRqp^1[22sbƩ TWWzvrX]#㇏OX`f4ֺQ_yB1kpwy.=r,dspS7# BjM~ǭ]] # ->hlƒ1r|rd܅CdV޻2Sd>1*݌XYdaRۆIOB!X;͞^Y2X`/QY+%~Al d͋\+,jE9 p@";311122gϞ[nY,VPR{04͍hkN >=#Q_yZ}ƍ۷Y᳒3WRo~V=O$q:UUUCCC wTD9 uuı~_:W (P/vXR-[0t8.\xG6nxsO@Q ޼yʜus7dƊ IJOOh2xСCZv|||rrrǎh4www}P$ z4*4#` *FýO𶶶(&IÅ֭vD2"=o.2K إ 1Etvv ~AAA ) b͌vjd@OddK?(CfAG~P&>FIx74@ 0p'`O<>}CWw J;wq *a̎Bt KHaE*1c'0>>~ajzzzddgffҒ!hHT`?Љy1!U]_~vZ#G]2*-v$?)9W3LD"q5j4#bD"Drss'&&t`oýu;9cȚ0Vv1|n4(RDH&F= ۷O|eHDբLɐ',--+TJ2 .!Ytbd\x,7e+sPD2YK̻<t֎T~Wh8li:#pڵk hp8F#6  sϕwttl߾=?S<  X,C(3<#3W\lPHuuuutt^/}>1F'@> 2 `4/_<66 y7xC#3hR=XO %EyA1 eee/^v@LAt&);;н~R;==裏JoϞF^+liiA-%D"a2@ U7^]p-cf\|*nj6;´D3P#<crg 﫯1gGixI 뭷9RJRW*6 e/T K/)}[s`"]y O0R&>ɤ41sZݍA2S@#c~P{j8k-<%J@ ^5'Ҥ%EEAw$tbx anNIpLDpI ES3ҭxA^_SSs֡f=:::>>l0LSsE8-QKKKǛANѱ ƷC_W+[[Zy~@fez0͏<JH>ԩS555֭zNg6[ZZuL(\>4#7!7n8[ln^# GZmyJ۫("zŋkD}A65B KwJ+ _zci?>- JR( E]] Iųg'"T43(&N oJۿ = bc# rJ͟0J%H+3 BNN:y,TUͧ!Q.-_jy`+@rv5" y>H3qI$Dv>X/D0Hxފ c /lyyoVJȽS4q۶| j/| @peŲby2::*`GtrjSng|E2dwcYh(, { SD7VOw--- !;;/,uZqTd2qKZx&1ju;\>q3ītw6RƉ łcNY(A2Ph4*)8S{ȚڧxGXyf,t $˗/[H$RXX VqNСC. j{{{~'Nh׳慌BRF8L9sk_z.\mooqF~~͛ :%}Pnzf\G^~vs^ BOχB!xdd$L޺upppl6oذ5/?Gjܥq_]]NNU^?11!"$I}-8QQbن?tPYYن \.WNNNVVk^(g3PG=p;?SձX }u&J5%"Iho ~H$$w ǹ@ gg_~4khV`0 qUiI>JQ2Wv"UA/*C- 'Z.p8! j2)qb*'V1#T J_Zwf1B@k>,[&=Sz!P%F. q49wK&Cܥt^ĘHP5JԤjm[R!RRBLrTvI΅www H[/RV\-TDQڴiht\y!P|IǘAҥK6M+0I$1CRL&֭[d2 UUUIjX2:2N?}tvvӧQ|ii)`g\1 )Μ9nZKJJ:::^ ~?;` ee&J-}Jv:thpp0;;gOS,..r:ډD"''Z[!HqVD򴆑3<Jg833˝N\NNKR1ƨWsRJFV8`٘_$BD6:رc z8?H Qu:$xm6 և~~$FS1R 딭HIti˘_saJK)#ߴ4h"L0(G*SfdcQS4"K8ò)cFίfr$"(Ը<>r{+pjH/;/䮌Ӯ,q0a,{'qΈ}*VbF&. b&a c!fh y,=B22E#ġ St67`͋~?c}9R/ (n'ޑ!mV`h ˟Dbtկ~e0v޽sN/ 07b%ɃFAS7~"˧iCvv6nRv&Eb`]BWWWJ%&TEYbdx)E R$H$"QńBYz6K&<'/T· EA ->+R G6뫭UTя~TVVh$ᴘ `g;w߶lvud2T*ZPUZDM"?}>,jllyyyEW@ī'0HrJII :sέ_'?IGGL$K.mٲۑH Joqԩi #1A>ݻwONNR^pjk<(ֽ^k^ X@`dyy9 >|nII)cr4UըG%r$F/SNH/ CYYիWEQ,**M'O 0_WWpȑZi`0 yH$'-C՝FR~_<@EEFYYYoooSTp8JJJBzSSS. 2 Q:QixN]k4tr#G`OOO]]]KKZN$N+++ =ݖdT*sssjk V/ "r斕y<ׯ ͛7_~vvh4xNʥVv]R>(h4 ӧOMNN_- ) t:CzQPP<44] Tk;RfC ~}7n |>BQYYܼ477,XJrΝajjѣett477=Bb6$tWEQ744dee;wOOOnڴpDRV;y? =555::j#*.@Ieǎ;=ښ=jfjqq_okkkmmEqllΞF$#3m QJ EyydRT'N)((uuuh){wĉ2\^^Fc8.))LT# v8#G檪*Njq~`0(Jv^  JFS>_ :#??^K&N|nnUJPpo߶%%%֭Co޼P(MR("}jNf .LLLBӉC PSS700֭STjl^6Q*Hln̙rbᨯb^2ݺu`FhJL:Hh`4׭[ @nnnqq j5++c||\444٥%ZfԞqR:H-jRF'''Ct2^^QQf GM&EEEyyyP裏>[XX@[2l0(Q-((;~C=DGii[o588XRRR\\Dz{{/_<;;t:.<@l555*jzzիeee=(e6~o24M0<~x8E퀑S>3xwaz/KTVTT ᧞zb1LDbnغud :._ID2tVQQѵkמ|IAle1ԧN<:mddN!/daFS^^mƄ!//OժTsl  6z=~"chZXyA/vټk.AΜ9sڵd2C!ύFL19@MLLNMM=cyyyƍ===n{߾}YYYJO6::z-ǃ>gD3D?3cҹ,KYYmnn2Lmmm b~~=;;poHq7 A ]PP x FS__oX_xcZ3d:=ϺKu1ͥf>V577wƍ='OVVV&G endstream endobj 370 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 371 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 370 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16141>> stream xŽyXTG>~i6Y7TAQQD5AFQ3&љ$QI$fFEjD%FEA7٥١Vսݚ̯~uԩsowWN{W7ol6f /_o>3{$I$3UD˿$3@ڼ["4~ԩ ,~zxxU|cǎ18BJSJUCD`O˗/Wlْe˖4GS<%u(''# h.] ,$IС̱@0gNflXҖD?88РA8p̙3a4;21̪mҊPZ9f="3dȐe˖ƾ} FB#0MyP^x K`(tyƦB45 Ι3FFF@~~> E[Jե膴 Ǘ𻻻OG:z(5 %셊APѨhN<4@ȏɻ]tgh%yyNʇVj )D=P۷o߼ysԩ 3a L9xCQbg!ų(1M(>*AirssϞ=D)/(Kp@4 S*(JPBpA򥎙@6h uww?9j(懰0b"fQT/1=ięL|h(^'u<@<iPQF MʽC1CEX)IA\"PJͅS26gۄRaruu /]~z^ڵnFeZeV)_t|Iww_~I]՞FbB3 աKD^x$I6ltE!N(mHHȝ;wZ[[͛{UXXsκsι<M *rcYxggȑ#OcǼMLﱓ5cWA!'O +V466롇 O40X`Z a5eʔk׮͛73f9rd}}S/L&G<.0E3gN}}=;wܹsP9[&<4ŋ㰰0}ڄ JPLӧϻヒdIFf!u(mMMW\ $MIkPE zD{ p RYLP6"?!7iI|\TTk.߳>HkǏQ Im[[[DDD޽EݾGAT9[)+[(~<E Hka+Vprr"Zhߢ%Vڇzh=p[dy,Dǹ3 @{P꘼RMFFs=wi>n[DT@]Id)<ߐQ'|3VjFfuGNwvv:L mFQhˁ &!.$gENk-CQ_$)V|{1#NL8>!Oe0,8"A3a!+lƍnޮ7mDHt7@r "ŠΝ;`25!% IV|>q$$$TTT D%kW$YF(Ed4d9ݼysfffnnnBBByyh>åǏy&$%%8q8$}E*B(f;vxΝǏ P 57-}m"Bٳg><*|u Lg10{옘̟?| rWU LN8u(R9rHs644̟?e+,Ï1 $IZ///NrJ,dr9&&( 7 ƂS{%&tpVh1"\ _8q"[{B"d-3r@YPP?/ !TxIHQ_֖_7 |E&ZHwryy:6\SFDDL6 +A|La9Z+"c㛌f1V]e !ȧ8BȖvV毇ש]`@)L4ͩ8_NR,efh g$?ƴǀj?(zͰ4LJ؄BiϘ@*q2dMtREcң'OYBX1UTK'Nc|z2"Lp*2hzޞ4cTFcz8T&ҭBC8JP zy)5)O 1%AF s ҮZjժUJ QqR>j{24F#}YO|;P]<m%f$QJ@iI0Z:TOT K$ 'jvA9A0W*pԡ5%Ɏϟ􅘘___+.F2,UuѬRA%g*eB !H 1:Dxf^%PyT̙3p[CKh05<[7B(ERIrEǚ2JA J$ !TZZ~$2-US2~@MڞpСbE,Zf$I}]cc#+r\Y"kBRuVN7x};wR*Zm̙;ꢠ Iյ^ԌcO>=>>o߾_u|||RRz0hLZ{gVVD].k#>|ѣGwvv,Y$--Æ <ɉVT >Sj+ڹs'/fZ[[  &/(`fU&2jkkku:ɓ׭[B/+V^T6OfϞ} ,ZA^\z>碔mFjC;fa_Aؓ'K=@isfDV$cPNTEFJC${yyyRR݃Gp1LțQXFFG]~}GGW\Eg8+A Gȑ#$]ɓ >1:o TFu1cƬ]#00p߾}UUUL߄ /9rrr wަ&g3wz0Ç۷A|||f̘A84DWN!!??ƍ!!!z~ɒ%3fw.J̕`BKd2~'|Ԩ)t'}E=lFR0ϛ@9vXTTT߾}洌P}e7T?>y26ЎlJyU"&t{R0y&"\TДVu#m4NJ3^ *LSP3y}l)Ғs*PH|YEP% BLPV*PwygԨQxk?Y򌍀uҌ$"a.рt+u(!tB2©#Qæ:' *&0ҜvpV O.|P"b*P 8ƘF^9L&999>2 <4?fJ*ɓ~^߸qÇjZ).* ͜<[oWr2wر:[|͹nJII@ៈ*("NA\XhM2B1aONN.//߱c;<@@>|꧟~*++۹s'~r{n? %*P&;;;,, Td2899/X.]Ti A]h&!WK&B+ aaaxcgx_8f$Ӫwً- 0-...<<8 =XK(N0p|kl2?lAU"DT|R|||BBB؄é?p;v !C7tuu[(~2dtuuu\ww7)ZˋOH* 0,J]RBfb"9oh87rW^@ !Pڶe˖)I_ڇMzU>(L^Jջ]ӗPUW/fJCz T~ _S '=P<P޼yoc h7xOWJMA>4 `R /B(h08 ֯>_+(g(^T(?8,VuUrmF\saޕ2E<Kd3Fu9NwZ-JS0h&S?aiܻj -=yy;6ꫯ:;;d;#; (q[ڵd2ڵ zhhhhz^ԫ4߷nB},|n*uJ񩭭%9-[L&SttΝ;M&Ӽy `Ϥ0EN.&Y+]񁶡aŊO>իi~\A ?z&J) 9.4c̳b+pPL*Azı7pv0 U\0ԇ޾f{;*33mwwwCCCֶ; &څiɰMc((adx =|$h?clū?bI~gݽgcU#-@"lHLF[ڵkG$ʕ+nݢȨ2D7ys(A5B_uMM B(99VnPVJ@~*oʭ[gff>cl7AZ8Bz~ gώ( ӵ*bD&55ʕ+ʶmrND.]]]ǏgjvM|2W :ٹ_~...uuu#U\w/bf!P} b./d@f.́bK,B_fT+] %VL|h[(ѣCBBZƔɱIsfHF$,b-!GVnL8$fd ?2$"1>TNh*'(?Lxg"(͸ ]C1e XBc_gaF z~TPPTU_h8|jme(fweS]OgE !"cV&iCpH(KL.CTUU) 6PhSRR:7enNޣ%B%ef~ ?f=ҍm_Wk{ 'If!hLqs[Aէ `݂f688xڴiG~衇$Iə;wu:ܹcUHdZj"J"dmhh:u]\\GKVԧarVKKKRX|@jo(WS2(?e'={v¶msȑB)49z^J p͛7FFFo_RXx 8\Z!r}lvR_TT)-B [WWd-ڋ3 lUѱ?TaY KJJ0?77*^_QQ?\ IKgI= z#L"h(rYVVHBBBҰ.Y ocb[`2$me"9 *..޼y{fؙQvJ(=74} 6333..nݺu'ニ@y3Iw+K cǡ_|"##=&!W29.x;kp]JPNwƍۭ:ߞOy +zWS,L_THbK]߂|Ѿ[o0( OA#+]b*4:BlJI&+b#/LΝkyb?M6ڵf55 I US_L6 JvS*쁒-H|%Ii$VDIT%//HYiT]]}o*V;/߳f.͙K-*𹿝q=BOJS<5kɿ -@ {(QH&!EHB o4 =S-CIٗ11P4E94a߀|ӦM[of#oS~eɒA'}(gP 7CzAaf\RJ3o<&(i*13bf9UT(ࣟc)A!%,*SGԧx{{  !wuwwggg?<>W7Dt+ Kߧ {¸ïJP²m۶>HINDOzxxׯlٲsԨQhР6F;ydYP/s"%(FFs,XۧOI&b+ ;Ez-uV<*))ٲe˴i}Q&d] > ZSnFRI.L󋋋c&ۖ8;:M# EW Œ! G ۧg];q(u1,%%G.__ң"M|H+4+10PhVmBi 4/]7M(tI?}$$ n @/B(KYYpg90<]`=/nL(S |,Wz"PANnR{ u0W(لUlJ[ZZZ]]hTylKٮ:yZ7hTԣ_BYC{ Ƿ𮄅:AG XPq$1;jYCi_>vXU{)3Z+)W  GʉN $! M; x6dw0BsK{ H^׬}fGpΚ5Ϗ7kB*[}]pU/*CeVfzy$cBj!񍍍}ݵkSO=S/B;b>(Muv0[ˍiKC]x1---''gɒ%0KxmCJt:6B(gTTԐ!C0\@@Nkmm4i޽{ 1T)tUaa%k1!j6fLTa?,f $OMbG{\ `M8jI6 ORXX p?w/phAA||B$$3 EJ[ZZZYYںh"x׉Ă =*IRjj^y ꣢ DwM6შ(<g(mf+ gNIC }>b?#Dԛ?G tBAy)>^x100p T3*Y$B% IR~ggxXX; "qS',9$BSh(!gDR`IB`f"rPɓ''&&=z4,, i{BM`0!p4L2yy?@7I4%i(.L0}A^@8LJu(mGGݻJ+lz/!zH@7@+%Yy'6IGHhQo,%dX)a nښ um!™ `"^zM:&;&؊]hcccsF//7$! tΫ=]ΊP h___p,77wݺuG}-;B*e"!%b<@ 6lP\\?VVV=zT8*}x'|RTTqƼR,;ISJګBo}TYxqqYrpgj>%~~}BH ...mmmq}}}GGGmmmSSSVVec1dz+=\4tF8ouu5B֭[!άk!P.aFOA4;յeqKKecgqZ.?%y&3#Ic=BB(I޸qc̘11͛7!ݳf"A؁ Α#BsFfؙwߙL&GGzBF6:5՗?@/Wك2Guvv>s Db(F1SZP=@/I2dVڢ7nlڴiݺu!Vo0CDwMHT8IMΨ2FKqq9HWǫJ [,<z8Jvƍ7nyqoOFz-F|d|CS9")AqM_Q*H+9_68 b&-`&SK-𚎖ElnGN͆[]p~^셺{R=PS)@;@@$#dPZ^ḔFl;6MlDX1JGy7ˁZd`QXl?`cbQn)pЛ}9~<-:wi/~IZ&%j}DXmePS mmmoߖ$6w3]%$ɘ^= zV%k*I'N9s.**GZ66^ 鍝f{C :u~g}ݯZQQ.JPt)}t:R3@aJJWalGϏk-(F\z3^zi r_}t}v -(/O0޸ѱ1`zon$)??_w*oTؽKz𓛛/?ۃSO%Fs)0L.]2L&i…˗/f%|;'ɲ.D577fsccY^kjjI6H+* N㺺N*:`0IѨ"K]]]GG]c6$Êƿ"%??Cݺu4lnn;6442TWWwwwӕ]]]555Q !6;9 !݆)'O|O>[sYY-bŊg}Ν;9ܕ+WnڴLLLݺu+cP~fsBB»ヒ)K٫W~iׯ۷z7~gW\YdO?D+ڶm[@@/BGhYo߾'VJNN?Io4Tyyih---~e˰f͚3g`IٮXO[[[O8hVZ7 .䔕@zzÛ׭[7nHLL8qbTT޽{qꄄ7n,\8}O>`0O$K֊,yW_}[O6fիQٳgsrr}] u7n8887ʕ+2+++))СC+Vɓ'/^s5kր(#}322p}ZZZrrkUUյkBۻ~ᇟ{9<0L;vӧϪU^|Eo޼yKoƌ37779r!<<%%%'N onn?~|޽&M; %==e 1=I&ܾ}3))?)SBooOsͲ24|۷>&iȑ~~~ǏߵkWxx ܂:eF_RR/^z+W{Gx~eeetT??aÆdgg?"".\b6[ZZBCCw=vظ4a„o%[)S_xgdd\4+Wl6&&&?u_Kkhhbbb.\ IRQQQbb_~9ei#:޽{ڵ{UA$ɔ_vwwFqٲe=PPP_|+ |'x2 xUXI\YYyALiǎJյ{ݻwL&>%%eرϏ"ο 6EEE$ VZ;_Fc}}}YYy?ܹsBᎎoL]&N8s̸8v͚5K,Zf imm5 \Gdp+,, GvYWW$45k~h>`ʔ)L:09;q~706l`]d61v5uE%&&*Sg977nf<Ǟ7n1ϫT`JR?A=ycǼ***BCC}{Qa eSN}םs:t JI fž5zGӧOaa޽{{4gB1GQWBb_}Unnw}};\]] Jim0SΜ9j4={v֭;.zFW޼y3666$$ &JUA途+WM6(Ba᥆䠠K \[ endstream endobj 372 0 obj << /Type /Page /Parent 3 0 R /Annots [ 376 0 R 380 0 R 386 0 R 390 0 R 396 0 R 400 0 R 406 0 R 410 0 R 416 0 R 420 0 R 426 0 R 430 0 R ] /Contents 373 0 R >> endobj 373 0 obj << /Length 12298 >> stream q 15.000 -60.780 577.500 837.780 re W n 0.965 0.965 0.965 rg 26.250 703.305 555.000 73.695 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 703.305 m 581.250 703.305 l 581.250 704.055 l 26.250 704.055 l f q 35.250 714.555 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 766.011 Td /F4 9.8 Tf [(Figure S3. Optimal vaccine allocation for different numbers of vaccine batches for )] TJ ET q 46.500 0 0 13.500 417.781 763.500 cm /I134 Do Q BT 464.281 766.011 Td /F4 9.8 Tf [( and deaths averted.)] TJ ET BT 35.250 752.275 Td /F1 9.8 Tf [(The delivery schedules consist of from 1 to 8 batches of vaccine delivered in intervals of 1 week, with the first batch being )] TJ ET BT 35.250 738.538 Td /F1 9.8 Tf [(45M doses and subsequent batches being 20M doses. Each graph shows the optimal allocation given the number of )] TJ ET BT 35.250 724.802 Td /F1 9.8 Tf [(batches of vaccine available.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 493.860 555.000 201.945 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 695.805 m 581.250 695.805 l 581.250 695.055 l 26.250 695.055 l f 26.250 493.860 m 581.250 493.860 l 581.250 494.610 l 26.250 494.610 l f q 112.500 0 0 112.500 35.250 573.555 cm /I136 Do Q q 35.250 505.110 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 556.566 Td /F4 9.8 Tf [(Figure S4. Optimal vaccine allocation for different numbers of vaccine batches for and hospitalizations averted.)] TJ ET BT 35.250 542.830 Td /F1 9.8 Tf [(The delivery schedules consist of from 1 to 8 batches of vaccine delivered in intervals of 1 week, with the first batch being )] TJ ET BT 35.250 529.093 Td /F1 9.8 Tf [(45M doses and subsequent batches being 20M doses. Each graph shows the optimal allocation given the number of )] TJ ET BT 35.250 515.357 Td /F1 9.8 Tf [(batches of vaccine available.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 284.415 555.000 201.945 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 486.360 m 581.250 486.360 l 581.250 485.610 l 26.250 485.610 l f 26.250 284.415 m 581.250 284.415 l 581.250 285.165 l 26.250 285.165 l f q 112.500 0 0 112.500 35.250 364.110 cm /I138 Do Q q 35.250 295.665 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 347.121 Td /F4 9.8 Tf [(Figure S5. Optimal vaccine allocation for different numbers of vaccine batches for )] TJ ET q 47.250 0 0 13.500 417.781 344.610 cm /I140 Do Q BT 465.031 347.121 Td /F4 9.8 Tf [( and deaths averted.)] TJ ET BT 35.250 333.385 Td /F1 9.8 Tf [(The delivery schedules consist of from 1 to 8 batches of vaccine delivered in intervals of 1 week, with the first batch being )] TJ ET BT 35.250 319.648 Td /F1 9.8 Tf [(45M doses and subsequent batches being 20M doses. Each graph shows the optimal allocation given the number of )] TJ ET BT 35.250 305.912 Td /F1 9.8 Tf [(batches of vaccine available.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 74.970 555.000 201.945 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 276.915 m 581.250 276.915 l 581.250 276.165 l 26.250 276.165 l f 26.250 74.970 m 581.250 74.970 l 581.250 75.720 l 26.250 75.720 l f q 112.500 0 0 112.500 35.250 154.665 cm /I142 Do Q q 35.250 86.220 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 137.676 Td /F4 9.8 Tf [(Figure S6. Optimal vaccine allocation for different numbers of vaccine batches for and hospitalizations averted.)] TJ ET BT 35.250 123.940 Td /F1 9.8 Tf [(The delivery schedules consist of from 1 to 8 batches of vaccine delivered in intervals of 1 week, with the first batch being )] TJ ET BT 35.250 110.203 Td /F1 9.8 Tf [(45M doses and subsequent batches being 20M doses. Each graph shows the optimal allocation given the number of )] TJ ET BT 35.250 96.467 Td /F1 9.8 Tf [(batches of vaccine available.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 -60.780 555.000 128.250 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 67.470 m 581.250 67.470 l 581.250 66.720 l 26.250 66.720 l f q 112.500 0 0 112.500 35.250 -54.780 cm /I144 Do Q q 35.250 -60.780 537.000 0.000 re W n Q Q q 15.000 -60.780 577.500 837.780 re W n 0.965 0.965 0.965 rg 26.250 703.305 555.000 73.695 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 703.305 m 581.250 703.305 l 581.250 704.055 l 26.250 704.055 l f q 35.250 714.555 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 766.011 Td /F4 9.8 Tf [(Figure S3. Optimal vaccine allocation for different numbers of vaccine batches for )] TJ ET q 46.500 0 0 13.500 417.781 763.500 cm /I146 Do Q BT 464.281 766.011 Td /F4 9.8 Tf [( and deaths averted.)] TJ ET BT 35.250 752.275 Td /F1 9.8 Tf [(The delivery schedules consist of from 1 to 8 batches of vaccine delivered in intervals of 1 week, with the first batch being )] TJ ET BT 35.250 738.538 Td /F1 9.8 Tf [(45M doses and subsequent batches being 20M doses. Each graph shows the optimal allocation given the number of )] TJ ET BT 35.250 724.802 Td /F1 9.8 Tf [(batches of vaccine available.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 493.860 555.000 201.945 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 695.805 m 581.250 695.805 l 581.250 695.055 l 26.250 695.055 l f 26.250 493.860 m 581.250 493.860 l 581.250 494.610 l 26.250 494.610 l f q 112.500 0 0 112.500 35.250 573.555 cm /I148 Do Q q 35.250 505.110 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 556.566 Td /F4 9.8 Tf [(Figure S4. Optimal vaccine allocation for different numbers of vaccine batches for and hospitalizations averted.)] TJ ET BT 35.250 542.830 Td /F1 9.8 Tf [(The delivery schedules consist of from 1 to 8 batches of vaccine delivered in intervals of 1 week, with the first batch being )] TJ ET BT 35.250 529.093 Td /F1 9.8 Tf [(45M doses and subsequent batches being 20M doses. Each graph shows the optimal allocation given the number of )] TJ ET BT 35.250 515.357 Td /F1 9.8 Tf [(batches of vaccine available.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 284.415 555.000 201.945 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 486.360 m 581.250 486.360 l 581.250 485.610 l 26.250 485.610 l f 26.250 284.415 m 581.250 284.415 l 581.250 285.165 l 26.250 285.165 l f q 112.500 0 0 112.500 35.250 364.110 cm /I150 Do Q q 35.250 295.665 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 347.121 Td /F4 9.8 Tf [(Figure S5. Optimal vaccine allocation for different numbers of vaccine batches for )] TJ ET q 47.250 0 0 13.500 417.781 344.610 cm /I152 Do Q BT 465.031 347.121 Td /F4 9.8 Tf [( and deaths averted.)] TJ ET BT 35.250 333.385 Td /F1 9.8 Tf [(The delivery schedules consist of from 1 to 8 batches of vaccine delivered in intervals of 1 week, with the first batch being )] TJ ET BT 35.250 319.648 Td /F1 9.8 Tf [(45M doses and subsequent batches being 20M doses. Each graph shows the optimal allocation given the number of )] TJ ET BT 35.250 305.912 Td /F1 9.8 Tf [(batches of vaccine available.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 74.970 555.000 201.945 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 276.915 m 581.250 276.915 l 581.250 276.165 l 26.250 276.165 l f 26.250 74.970 m 581.250 74.970 l 581.250 75.720 l 26.250 75.720 l f q 112.500 0 0 112.500 35.250 154.665 cm /I154 Do Q q 35.250 86.220 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 137.676 Td /F4 9.8 Tf [(Figure S6. Optimal vaccine allocation for different numbers of vaccine batches for and hospitalizations averted.)] TJ ET BT 35.250 123.940 Td /F1 9.8 Tf [(The delivery schedules consist of from 1 to 8 batches of vaccine delivered in intervals of 1 week, with the first batch being )] TJ ET BT 35.250 110.203 Td /F1 9.8 Tf [(45M doses and subsequent batches being 20M doses. Each graph shows the optimal allocation given the number of )] TJ ET BT 35.250 96.467 Td /F1 9.8 Tf [(batches of vaccine available.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 -60.780 555.000 128.250 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 67.470 m 581.250 67.470 l 581.250 66.720 l 26.250 66.720 l f q 112.500 0 0 112.500 35.250 -54.780 cm /I156 Do Q q 35.250 -60.780 537.000 0.000 re W n Q Q q 15.000 -60.780 577.500 837.780 re W n 0.965 0.965 0.965 rg 26.250 703.305 555.000 73.695 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 703.305 m 581.250 703.305 l 581.250 704.055 l 26.250 704.055 l f q 35.250 714.555 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 766.011 Td /F4 9.8 Tf [(Figure S3. Optimal vaccine allocation for different numbers of vaccine batches for )] TJ ET q 46.500 0 0 13.500 417.781 763.500 cm /I158 Do Q BT 464.281 766.011 Td /F4 9.8 Tf [( and deaths averted.)] TJ ET BT 35.250 752.275 Td /F1 9.8 Tf [(The delivery schedules consist of from 1 to 8 batches of vaccine delivered in intervals of 1 week, with the first batch being )] TJ ET BT 35.250 738.538 Td /F1 9.8 Tf [(45M doses and subsequent batches being 20M doses. Each graph shows the optimal allocation given the number of )] TJ ET BT 35.250 724.802 Td /F1 9.8 Tf [(batches of vaccine available.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 493.860 555.000 201.945 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 695.805 m 581.250 695.805 l 581.250 695.055 l 26.250 695.055 l f 26.250 493.860 m 581.250 493.860 l 581.250 494.610 l 26.250 494.610 l f q 112.500 0 0 112.500 35.250 573.555 cm /I160 Do Q q 35.250 505.110 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 556.566 Td /F4 9.8 Tf [(Figure S4. Optimal vaccine allocation for different numbers of vaccine batches for and hospitalizations averted.)] TJ ET BT 35.250 542.830 Td /F1 9.8 Tf [(The delivery schedules consist of from 1 to 8 batches of vaccine delivered in intervals of 1 week, with the first batch being )] TJ ET BT 35.250 529.093 Td /F1 9.8 Tf [(45M doses and subsequent batches being 20M doses. Each graph shows the optimal allocation given the number of )] TJ ET BT 35.250 515.357 Td /F1 9.8 Tf [(batches of vaccine available.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 284.415 555.000 201.945 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 486.360 m 581.250 486.360 l 581.250 485.610 l 26.250 485.610 l f 26.250 284.415 m 581.250 284.415 l 581.250 285.165 l 26.250 285.165 l f q 112.500 0 0 112.500 35.250 364.110 cm /I162 Do Q q 35.250 295.665 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 347.121 Td /F4 9.8 Tf [(Figure S5. Optimal vaccine allocation for different numbers of vaccine batches for )] TJ ET q 47.250 0 0 13.500 417.781 344.610 cm /I164 Do Q BT 465.031 347.121 Td /F4 9.8 Tf [( and deaths averted.)] TJ ET BT 35.250 333.385 Td /F1 9.8 Tf [(The delivery schedules consist of from 1 to 8 batches of vaccine delivered in intervals of 1 week, with the first batch being )] TJ ET BT 35.250 319.648 Td /F1 9.8 Tf [(45M doses and subsequent batches being 20M doses. Each graph shows the optimal allocation given the number of )] TJ ET BT 35.250 305.912 Td /F1 9.8 Tf [(batches of vaccine available.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 74.970 555.000 201.945 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 276.915 m 581.250 276.915 l 581.250 276.165 l 26.250 276.165 l f 26.250 74.970 m 581.250 74.970 l 581.250 75.720 l 26.250 75.720 l f q 112.500 0 0 112.500 35.250 154.665 cm /I166 Do Q q 35.250 86.220 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 137.676 Td /F4 9.8 Tf [(Figure S6. Optimal vaccine allocation for different numbers of vaccine batches for and hospitalizations averted.)] TJ ET BT 35.250 123.940 Td /F1 9.8 Tf [(The delivery schedules consist of from 1 to 8 batches of vaccine delivered in intervals of 1 week, with the first batch being )] TJ ET BT 35.250 110.203 Td /F1 9.8 Tf [(45M doses and subsequent batches being 20M doses. Each graph shows the optimal allocation given the number of )] TJ ET BT 35.250 96.467 Td /F1 9.8 Tf [(batches of vaccine available.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 -60.780 555.000 128.250 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 67.470 m 581.250 67.470 l 581.250 66.720 l 26.250 66.720 l f q 112.500 0 0 112.500 35.250 -54.780 cm /I168 Do Q q 35.250 -60.780 537.000 0.000 re W n Q Q q 112.500 0 0 112.500 35.250 573.555 cm /I170 Do Q q 112.500 0 0 112.500 35.250 364.110 cm /I172 Do Q q 112.500 0 0 112.500 35.250 154.665 cm /I174 Do Q q 112.500 0 0 112.500 35.250 -54.780 cm /I176 Do Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(5)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Influenza)] TJ ET Q endstream endobj 374 0 obj << /Type /XObject /Subtype /Image /Width 62 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 62 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 399>> stream 8c`0b ul;7c B*fm &Aɚ3Fx5gMٴƎ c`rH f: Dy\( o &sSsm BǷ\8$@9܉ljG39RUwAFg*~:DP%b& MU, J\9"DY8 4=t$; Q>Ӡ~sHn9%$S pD@( JADzǀQ־$ HYzy10DaCL CB;вYu$I 'TKClŴ&v}JY\l,5t%g:`E+M*"[7JH. endstream endobj 375 0 obj << /Type /XObject /Subtype /Image /Width 62 /Height 18 /SMask 374 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 62 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Oi  & endstream endobj 376 0 obj << /Type /Annot /Subtype /Link /A 377 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 573.5550 147.7500 686.0550 ] >> endobj 377 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coveragehospitalizations12.png) >> endobj 378 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 379 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 378 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 15819>> stream x}yXaPdQ **உ{\h&In5Y,,hbEju 0j4.(Qe}daQLQ]U ~<<<էzԩSzzz@ӽ;vX,ek֬ILL|222}كJ$I|*Qf^ @X;F)]%ӦM[xqJJȑ#ׯ_;:uR6P¬;F*B(^fksΘ;w&$$8J]4HFi„)xJJP@cǎ+W<3!xwSRR{1WW=zL>: I9$Lע|VWWKꫯ-Z4ydF˥3::?piie˚^}U???XbO(%,T$IK/kL8qĉrhhlr cS'Z*h:o<|:fʢHLj>ۋuZM K믿OB'Odt> i>t*ap-dh4Νc*7]1 ]r7$:]ZMnVShu }B'LO*4enP߽{wڴi 3^hrvL塘BPYȀ@:JbL*`Ρh222/]2lо%Z$`NEEE#Q@ف13Hm%(ڼ@IuvvѣG7?Vlu}q0H1yatiB:DvZq fs:@F(|=zt~~~QQДA mb$<4q@)U`Lɘ[X!,h(VB(׿~͛o߾VVV՘|Ad/: ~MO>駟}7t%\ZK$>g@D|k׮Im۶ׯ2`e)mnn;vݻwŋz˗7sUq[žʈ'N$$$@LLӧڢ(uh 紒hV{uuÇccc322 ::lfx2(qۛL&lӵkצi4{ԩS^eZ HO 胵ksҥ@mN(Vn a5u۷o/\p3g5jTUU+਒+J$mEEży󪪪ϟjԨQfDm +(xŊx!'=az%QOh+A1ү_?LqBn3hˏ92|p.)&JX`LhzDlgECdJyr2(:%I%((EH[WATF9eWP!U(ڈ )Wf% 䀌-P!ҥK}||zq(_DSUdەiXKYSCi^x .3T/ jSd #astܐ.'|a-iFZJ W^z郍Rt4Okk| j6+~$*̪=ug:T4=zX,(99y׮]z~&}@xL ?E|rddl>r۷*4&c/46B}ٲeKzz:DFF޻wO/F4+a &55511 ;vsNFFFdddqqd|CKTg$Tt(3GqCǏ/,,<}ݻw &&̙3y%=qVm i I!SN߿?77%%%}U.b=fJ"Bs綴>,X?׫lUiGL W>20w܉'VUU=CXgѢEs`*?ׅ"pPpԨQ{?~uuEz=Xbʔ)ĸGQ;0(Innn:nݺuXuʕĉM&]AMy&ζ/"> A1%.ML4 =Θ[Χc:"mP3fLNN//$KB JÍbPLWa"\애p>4iĉ[ >}:+) !B&XA+dZacZ|MΪ|udw1clL48C_NRLdfz("~?(zͰb+1(cgX߿SO1y 0ݽo߾ngIDId%:PXp IoHHHffhphlmm>}y$CFM/0*3 FJKKO8l6OཕLRR !ϳ hkJ4x`??ԟ7tS92+ܠTUvڴi^}UL=_z5^=]BĮҢ 0Ls. $);;KEP|zR(]E 'Ӈzo`Hv6CgϞz>221231Җ>?34t,CvܔO 1;sv(ׯ_TA\4acK CLn?U>XB>ヒ!UAf͢[7&'WM5?ޫW/[FcBBBZZʕ+nܸ1lذ% wСYNZm4Ho>Pdk!xyytfOO!CDDD8;;< 5k 0*)ӧVtSLݴi#_׮EPԺs޿n˗/ѣ-kȼ 4m ϪkGt[fWP hSbK n!* ̱:N%Jjْ:Ct (2oCi_\\A|#Yh8˜f&MX-))?'On޼`00JTh g%(᨟8qX7xܹs >.ctQ>ʕ+!!!o`>tPiiiPP7& t<I$.aB=z o@z`4cA _Qy|GFGa+JP]RhEEEׯ_饗njSXX?G;B.,))5jn2GݻJEEݸq c}Ihlnnn(AE5553& `…EEEK,Q( FP%'''44THT" Q ёݝ^{ M<)K/}ގxG.V#G"WDy5 .<>~1CȫԡH4{l|&I~vn pImmȑ"/޺ػwoE[Hf+E^z<*T&qeH B>PaDH!M/%///'PGeP>...4V<90LD<DiU m0R_SWPpAUASїpB0(zrO ,Y )Hec;w/Ϗ?NfV{~3YU{%%%Լ{O|#׉t Jӿct:<;vΎۿee%(@=g!?\x(F?"""66x߾}C)6Iouҟhy鎊"\Vm~xWLjXWD%fEc(!\B˗/Wh4`}%*,l KHHxG ի]]]`ŊJ] h_{5 K.]lpB|-&F%t.*K}fcY#?ɷtX(EkߟWbJ{]fk :IO}[$(muJS__3L4W!#z C g TFZ\Š݀Yֻ 5L:چ"ފ*Udm\%gv UTGJ쌿Ҿ[јɼD/wO{+WDEE樨(/ 1)2@Q%!>,;;!_} +Qejޫӧ? ;w4Ǐ߿l^p˗֐'ڥEH2($Oz ""uȑŋ0obeIijj:ri?ꩣӧgX]VSʦEڶ6r>} 9V0|N~--P[q( E (D\(j м{$IVWW]ڰa͏@ʙ2￟D?]YWw~Yf1 39;PJrרB1i" wKipIHڪɫmC:[餕v0apIsyL@$ 0qWki#(: JNN?wT&B$,Yמ7ox ؼ^蒌vg]{ӵuuX;9(`]=-b!Ο'תWMP`&Q灮 t%Ħtƅ`iIڤ$b"<`1әEԫp.p=ƹΫQn*SRPj}VҔ 9d䐲D:ȊЄ1q.4ɡ<+tG EN_R2#j lh_yVqXL}9k /OJ%ӜY]@*566;vLj%:GQ6 V9fuNTڏwg8ȑ#z36Ku(C1$Iڳgϫ䄟ɂtH@b©$Q$Jol^zߺu ?g3gn'@5@ @ @5@alEEEy f~3H{I fU/C%h4:4??ǎ!0 'k 9hh2JP!;w̙i&l>SO@Pgf8Y_ƌYYY--- ?Ca=f (T݉QQQ9kș҆90G.)0tr}gju:]zz͛7mdK" r;3a!O-N{#'zs? AZj2HF[}{=%1%BG_ԘB.=Wxb;6A)) %d{q&JC$L_R-B]\Dm"+PFGߩ}uH9u8r0EѓR-W. hPJ.K(VD&UqE>nӍjXuec MY|HQ8"8x*@Q(:0y&BƋV%Lj+OshȞ!Ty&ypg*F,C1rҥf˗O_V2rJ o/"//ﭷ:~xZZƍms]ݝ%wzT2qqq]z~Z\\}͛7bgRի\ \;tpˆN%88~Ϟ=qqq+V4h+*i`0;Jvvw[7TӅ;Ӂ ***7oLק֮QI@Kmm-B(;;7pT>OC*׮]+//1cFJJJYYٸq WɻA饗^6BbX[ ,Bo#b!4 WL&$IB-0 ڹ#C,ӴUaZjHju(V"kU( G*IPǒ\"g>/4+<@tJX`;a:\TTwލy -Jj>_EXrLNNNKK={LN0iSC1./;wmvR]Pvӎv;quuxbHHȦMxԩہt.0 {{7=zjذaL ?"Td|\UUe6SSS/1oii Cl_*...**~y8lذ={_0BQ\\̔3U&]Nw!TTT`֠ Bjmmų1:XZ#_dMZ7n|^%1L|yY_׮uXY~Z̶{rafaÎ=:|%]NF +Jٯ_? PHHHffh mii #hb0 I5jN9s&bƌ|uMQ~,˃>XSS3sL>  8F tJ >׮]k6n3tdC”PL{wpӦMCeeeɋY-2FŤ^ xzÆ ۷o:w\8y򤃃V+<?#+0>Bchng,^/j .j4҈_k.Ns!;;;<#TyZB _lEjGDD?**駟D`iU9Єn\(qڵ+W=zn`ˡ!g!J|Z,&qs# `yP544tȐ!ᱹy nn}$y܄0>d2fzh}$J}jkkфZ ¤2&̀..='ba2_H蘛 . C9"$UŒ~(j%%%˗/zh,^d2ξPPPP>>>rwzz3D?~n߾@VV;,)Up9)+OpIgpvWKlYJ"P:+k׼׬Y.X8 a[\ "l-PqI%JXqBDyTYYiXÏvĜUK]|%AD#*E;eʔÇYp.n&! ̂F{` _͚(VZf)XB2#vPbZBS1mmmrk(JO Q^RTr`~Zpt|8*+0G@P^JT?tAFXVf6@h_*C!4Ç>}[>jiBR!adP޼y ߿o܁Ҿ:$Ђ$ P^-"n111x'uWbJ^` BisssϞ=Isww?&Nʡ 2xya+?`OoH2dP^hK){+KKK###?9s3NWQ[TX j IPs۷o׮]{7x ۺ:vKqy$6^ӀFo'Biϟ??mڴzl>R]]]WWgggWYYi2>FYOR~?Ivy믓jk·Ξ=@y [n7//o̘1&h}bʝ2 DRX_Ӆ&,<<<..///ٹ 9BV@2k{j"$@cmss3& >>k6=<<3  PA2ֶ]`_{M(xTN@'_Y^p!dee1x0 G{xd~n~$!p?nlh>lɓ'==٨ LI rgB͘U>X(y.]RlXc)/<^&s{ח^^~Lq具^ա~+W_Ue%]e>!* +IZr' Cmm1p@lgg @Ҷ)(YYk"_fj M7?e3 j /`(N& ^S /X.lF*!foPvyY,%HN*dTf D1ЁA<>_S iSKJ^^^(?@:µZ/餉O{}eR@.mN851_Ɯ"W[Ḵ+maaFpBLL̢EjLӌS@ *v4N@d2ĊWc(55.XXT7:6xquŭ t.<ɛS%nnn ,0`@rrN6lXZZZjjaɒ%) ::zرs̩6&LAp N_Ś:ukpyRRҺuhMŲnݺcǎO<wC7.00Acǎ%&&ڵo$566>|̙3ƍ?daaaG.(('O/eIIIw^~=.ILL\|޽{%INLL?~nXBBBnܸA[7ZEENJ+~czjժ,Z:44[lٲeb=|pUU~ ~,S8qիW%I;|7|3uTA*::70 駟UA$7ߴ &iK.:t_ srrzUVnmmmhhìJƒGbJShLō;vѢEd?m۶_~+//O$^L΋d***:z|W_]|Yl0ӧO3QQQ&M5k֜9sۍ7\244tƍ4?Qȑ#yo ?0`@]]e˖S2(/ arPYYyʕq=3:`0÷m+W )fkkk]]]TTԴiӖ/_~a%{ q}||> endobj 381 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coveragedeaths14.png) >> endobj 382 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 383 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 382 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16196>> stream xݽytE>JBHI v" .3;ΨqmdPBAB$d!FvrQ΅Y~tWSo[}aX};ñhѢ+V$'' QQQ[EQEq0* 2TL1cƢERSSjժ_|1%+P;VXf͚䰰7oܸ1))IǁB"Gbbĉ'L@8p`TTѣM&}q&(&zp(F2_~aaa]wu]7gULegc/qb1SeX\\l2I;waàM,jX[(TVV.[/ sGGǗ_~i< 8Yzu T(Ey6P 1KPff2:b WF5;zD{ѳ)6+ TFF9tP=p(쩋U%fdSS ju()ӟ 8=iR1wibqc(5'@ʔ]-;~….ݬzKhMV ^m\oxZK,wjLNN>zAdl,'XU1%rW^F_j.PR]-R]-}$4\WJ2o5j&WFʕWE;0|pE"O qA6]LF/**ӿub*?YCqi)N %%C҃2{{{GDDPӧO/O=T~~S/^\[[~pUU@;y \iiSSSy-[ 2$<<L(--՛X({$کZ"F@wqɓ{Yf@ Pf#E$N՛ 8(sdd+W}||rssmVUU5wܸy@W|f$֤mIs}ϙ <==oƟ~iĉ]m=~Wt%=uP1Bq\ S\]R(2̵62~衇M&?|ȤP +fqB&y衇jkk}||n0F9{v9.,u לTӧ;wn…={ȑ#xHCZVR(see󫫫Ă ,X@aȑvE ӾEQ^zMVi0L= O>=hӰ4k+6L}]tt4?\3NP%nB yҊ"ĂpP,T .FQy`zK L#FٳN>A #27}T :(. $|m 0O`IEJ0閽ZdׅqғBcPG}ՙl*Ú^A1ҫѫ 2P%)Dz|DW\l;cѣGKKKqq1W\X=+ɰEpEB5^KT`9I 0q~ _ɹűJILf]paӦM---֭i#єX J8(رc[l}ݹs8&R}\>ǐ-¥k^x-[JJ|܄`m]ʔAׯ_-[l\`?(Ԍ*-57NL$ʍQ 6㏅{ ""$5^tʔ)K{9 7Gm& b,uQ(JQP{ZT4z蜜oF8jC&A )Ժ@LstL$=ewΙc9R|.-zl1b̙3EҩNth)B+6jQ(ﵸ(i-k+c1)O)xqGP=7Urs~Ѡ(0vA vϩBWsP4"TWWZWW U ibgbr$*02nso@3j]?ъ V޻wZQk8'/pSP.gcѥs9e=zovYYYߟPUUu=t[_'}m 9ӧO/Yd׮],s@8Q_#""Ν+4KXL&$u"I 0??믧7n}^;v[[Ç۝K{^M[Ϗs<8sۆ#G:lΝv=22 Xj՚ob\x fϜ93--mǎAATPnZmJ|3f<3#OA?$w7C]s](*a|` 36_a^)WBGڠlf(rL_\\TSS#""2fIy1*KII߿7hmmU?W@9zP^駟Ey:srJ8kr{WDz:qرc{ְ={1B\Bp@6v],q8(BGVVVTTc=fZG{:g"C J,hXΝ0`޽{ZJL*ꫯ (**:{d0a?~iikbO?h999ϟ:thhhhxxx``ٳJYttJ}K̞=[Eֻ$1׃?h7<jJ$"^l U_mm-}%*Bqu%8p &&&44+ʸũ(蛡^>*T@[&!w el"Ci+PR]@8P@Hg 4Y]tԲ'ōT&ҡ?2]JH -s\q>n4YI@qPD{Y cK\$97` % LQ}Y^:,5yNGz]7"U|"i&l)c(!5R2ҡ#1ݦ1пضI;L-q)m3n'I@bPj>f12zSRR466&$$ "ipС?ժJ9s1fX_NII}O:%bGLE(Shhq, 333/]H7:v؞={*,RB5a6ծIņ nJ89;p۸ ԏ?XVVcǎm۶;Gv?-q16q5d2EGGWv{ddd``رc=<<>)w\2 !!!!;Kޥ>c%R={LKK뮻uѣܹsAR %Tmm5kv,Nx:6Sl\[(1;T WPb>?"eX,UUU q:u*w|_߽Yr@RODk:L=mxNP<9]DzYb]I~iРAWDRͨPe˖IMMM`@a(8&R+FgtIS77JjC*yhuy ޮD&T=5fdd-8tbN+;A! ).g̰00+¤e ңp EףO>ګW%le_|9H^bUfLVh$r 1QMJ${P̥n"SLLfX,WE@XV<ȻD }lӠL !DEW eOKզ~i[[[vv-[j[47V Y?Q{ZL4ĉv=66 WP__o 1Et!O>B43%k hJ e ظqn8qmv… sss']14bKSiuÆ Ç߹sE/e %+m3;"p$8=Vq|СŋLJD۹{4մՕ @iVeҤIt>}zfff[lݻM&SdddRK6)9)S,ٳL:ҥZ"2(~ 7 80**l ;S.&_{5*$JŤ=p.G4r}PX $(Lnp@!TnzPŋo߾ ӋY$u,us^[(ΌT(i>^wm/Lz@C(SGGGMM-p^lͻ%5sw723A:&P(OZ988x„ B^^ޙ3gnEQ%K zl 3sQ);EQΝ;WVVv뭷9s>]$cdRR(i] P7o^xq߾}FV=IO7P٩\-UzeYYYsMVkTTTrr,YRRRV7wY{s✤87lP__?f̘-[̛7o%%I`Rj|C7gΜYf|@2T`@dE _.\A̧O;Ӭgee7++*88 Ij m\ P__7|p*opp00Ndeei׻2d;ݻwssܹs322&LPZZ [1ͭ੧{TEv'tg߷o&7yvೱ?қoIe̙ ;; }hqww׫9x~L[yI ީNFXz$PK28dz[ǹ"OPV/&S8Bu|e_%ӕ-$D%=3fa.E|b'G'')(Q_/@1*3vX=N>P%c%QhF>6-,k;Qf*-}Z'6566&&&۷n ]BCmnQ!u:FwvVt66woYugI(c{c,@NfU1+=2GDD̜9s̘1v( ,8qbYݹk.$ hWt)@{UYSS3cƌzyyۗ$#Gi} uD3gΘ޽{'%%͟?_[ wګzG >*+sVVѣG͛G/|ա?SLLscGٮa#F;.TvDX_r?^ ٙUcf-K%KhlH⚼y/;!!8 `Uihh(k/DSj-d!7 t΅_=KJJ菫II ApݠUgSw9i$vR4 !EEE5Ȩ$j@Cl*+j6cܮ1?ˁ3SR[[۠Aׯ_777;7vSYYy<|^ mhxRy=ͨϟ;wK/D~I#]ZO]MMME'z7Zֆ\x+Q366h7vBўYm  1$ROMŋo񆔫Ye˹Z(a'1+qؓR/:kLټJ207WW|d"@T&v'H~E2\(V/J)]VqdV".e <.o nc v\ȱ'g&!0Hzivˮ q7AfEVzJ ̡(`+`EbchY/>a`丸}MMX5_ #lziպ!m RbSMuuuAAIjkksrr&L . ܽ{~eU1Y\\\__?jԨ3gП e {+*PDJM'NѣDZcƍ_Մ B>[YV] !~a^^??^$<;4[nʂM} U/э{uVTT÷1֤rR3Po-!![w1t1cƸo޼911{ݲeKwuY&q~ HK) `+y7]JkYZ̙[ccjllllhhꫯ$=bt+WB.]T\\ss=זNy…tǏ߼yf`1U1gҡC***ϟWH&uUP;ȑ#cǎ}饗w@n'QK~b{ZZСCW^]\\`Hp7L F6!$++kiiiy[[!M z ȧNڽ{w[[ۗ_~,m g.RL8wAI|PTTG鉹h쎚Pf??}VWWS75*..￟6mɓ'{I8$m8qrP\ڸqcSSSttufϞO$$$p l\=).ȑ#.\(..֭[gۇ wޘI&ձ*^4PntN6RZZjZGkkĉM&ӝw}"@B \ }}}ÛM&ĉMF+VKW lcǎ-ZjgԩQQQTKFĤVKɘ`qqqtp{K{"[w (''/]b3 K"A]"1驹(11;lf|x/2[r;/Qt O"@}>PK@[!P--$Ο:ydRRRzzҥKqx>,"=mUI1@ P Mˁbh#2 8…X,S޽xm\S uYRhנEd͐H掎GGG7 +N!P[Ij]֛';ߖOAJ zS)@75kWnnnPPp#@}7Q" ;bNE׸(F]he.,,,--mjj뮻<ĢEl6/@3(> EfSBkD-H׭[GbbbYsIJV瞟?ESz2hNDR(ɓ'VXh4񌞁C ii%vKZ*P֒DJ|l!v3F7D-|x0GDte6mZ\\U?*{ҩۀ&7}c D[5 %/LݯP !>~h:~-B[[[wE7v֛ 4Բ,Ž| qNT* JϓP?|(Ŗ%X‘Qrp;;r{}PrUwyx{xzzR_f>>>3f̸];iu}uQE{$XJ%-"ܹ/zgt i?qpǴ.M?0 Q1M[](X# l6UWE/epiJz5P12c7 XJj^;`F(Jq\c9sf^hUTT$&&cqZvRcW)IMB.nnn3g\|YOL $U&7ȴkV*>>ә]tu]KHhMH/ :P_~E?SSSٳyf(ɉ<}i B:⠸nݺ7x>q(697sܹwmll|^ThuZ>6۩+ŵ5jk|jkkkP_uƌc\SSSWWVUUeـVg*&U8YhkkٳgFmـ&(쾦76|ʔ)8I讜8_MA&D?DK7?n`6ѕmm$6$l8̉'&$$ŋsi b D(U]99`6@Ay{zEyBgc<GŇf ^%iAU\FQƮ}ylOޭ4h3Ua`!$/uPi+FL1cAm Wߒ ;pz/9y̘1nnnAy)Ӧu*+]Neq z3;{ѣkWRBϪUJ@od;)AHUɦӧ@E[ۈqг'|zP 1gѰ̅mmm~~~,3pNd9R PZg8L3ݼܼA q#U!B[qZZZ(B#U{ᗒ`8In5RЍU***8H؁6&[@ q*P_vЎ0dzfh )JrsO&544l/h؄WVbL[oϑ K{-.,; wJ3LÇr-"Lوҥ@*#"5ɒBwne8bʨ>@gf.}B&f6(JWcTRfRr羳@PͅgZUH3A3`{1cLIHa[ù+?'\… IIIfG}[oeffVUU97v&-&$`"!E-8(k֬ZqKKscgps,rbZ@5}i x͒;-,{oʕeeeYYY?,Ւ4,X :5oYX P(@:YJ&BBWss3Uhuuukkkeee]]݅ ܜ;w֠j C((J_ 8Ģ(MzZ^^N)))tRee%!Ĺ.r&E"} I"]A~>e(x4*Vujun,R/?Y 7`n/yH'b8(|űc>cThnHGG 7n-iMk̀?E$d P (,kkz v{XX؃>X^^$vKC_BGH%0u;wYPĝb'0B===90Q8JBBB| @Qzqgǎ73;| !P !漼/[^"f1'E E)ހqz}H9_:Ռ&gvyF'`R(!՛PXI!=rE 0yUf}24ـ2E)<)KW)ti/Hª@bb< Ħ( (}x)]ŕ$QYq%( &j= ܵ te+tQVz *d&ɂ) ^rEikx[j89bECIB PB`1Rw9Vr)7hҡҵ]_3a#ݝހ!2RՄ&. #W6E:^$$Hšt hY9?rmq{S(89ߤ֖\:q `g3yo&º^F@l%DQzRLQ:UY^ͣLe] TpDwg؉ҪA6W/K@gv_&+ )z+JbWa/SH#^a#PQ*777[,}^rE (dF `(t2F!7=okk .//Ij(u)W (S$JW\\Q\\oB*9{]a%LSz뭟ȑ#J^^߾J/{S3iαӑeEk2fi3fx뭷>裵kvttbÇ kkkE/W@9 Hz45g2?Ә3`,M "Qzٳg}O? sZJ9:IgϦyy@Y)J?W;SCŋ6w@ ٚfEfggLʬ,-[-u|ˉ_̬ ٹsGpppw)%YULd2vSvn_x+\|7Jf}mm-v|GGGEE<}n{]bposo㪪6IAlEѾ_WWgZmjmmes*)w唗l6xvvvkkbtRKKZQѾ>_SST^^fWTT(wvTӅl.:thJ^z?EEEC=_rUg}o]ruֱqqqAAA6m*زekF)KiiiO=? ^{^xom3g.]c> $$dΝ~u8?͛wUK _h3ղ˔)S?BϜ9j[˖-իWGDD9rJjvb(?LUV}g4?!!~JOO-HNN:th]]]~~K/DwŸɓ'޽-//߲eŋ/^\\\Li>|[n9|#<1QB***Ϟ=ݻ>rap8Ξ=Ko=z4""#==^PGx񢛛.\o߾znСC{mV^ 8ؾ}+RRRh~RRRBBwYYٹs! K?裏[gժUO>$233Νo^}U.'ΤvܹsҮ\_̚5k… .|_xٳg:488ooll駟:::jjjk׮ɓ'>1""b„ ={,++:ujZZZvvǎ//d//shNse|鄐_|^X|yppp߾}iEEEv}Сaaa7o.,,[vȑ#z]RR2a„Ç/ZGr{=jԨ삂;w>SfJNN^reUU՝w٫Woo߾.\X,Ǐݻ!C7b/r8V5**j׮]ƍ;wnMMn4ig}e8{5}􈈈'O+WcʕꫯZ611رc{?~СCEٷo_rrM覿466Ǐo9a„QF t 7|V9wu_|(JKKK\\\rrrddĉ{QQQA;vӧY-Jݻ{뭷7٬|MMMLL˗׮]vZÑW]]MҦPJ!!!_o(J^^^\\?ӧ[Nz׮]=\kk~_(v=!!gGG+`ٖ-[vm 4O>999<Dy744n6`(Jcccii޽{)[u|{{]veqr-111w}'CBBEiiiihhhjjbkf.**ڻw﫯;vL*g|wܱm۶*=y [WWʬ]v\8*&zPUUuĉ/_7Z[[Lr?-]Tn1bccg̘q]wSS__?`od )3mOcEǓVŋ dɒ#F7꠽o`&ާ8tЁzURRuwFDD\dI$ 믿_jkk1bĂ ܿk#ClN}}>}޽cs!VI~駙[n6(^ﶃtȑ/d2r-Gݴi}th@>̌)SDFFҭ8WJ A@MgΜ4h̙35@ K/$$$ 4o2\(, v endstream endobj 384 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 391>> stream 8c`0b p@(mftt,[BH d>(k> Ys) 'S0lQJgbhCTƹ6w!~$,`sI H_s3z**E*P-@ 6m NPLTUHy@bR$-cٯqHq"f]0VA\=t@ǎaC!l)++;ה>(!m9%$SŒ)`@(4,@sIcB׀T@I?KO?&s3lxvbaBZ609ZK0```/SX) D?GV$1!_Ҕ"\ =" endstream endobj 385 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /SMask 384 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om_x \ endstream endobj 386 0 obj << /Type /Annot /Subtype /Link /A 387 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 154.6650 147.7500 267.1650 ] >> endobj 387 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coveragehospitalizations14.png) >> endobj 388 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 389 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 388 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16043>> stream x}yXG沨 "(\T5!dL4ƌ$3j2$O2YUd2jb45.#o]r-}>[N:v_to͛m6f?+RRRy_|q$Id#J< UcuN:w>|999'(uJ%R*g(̽{X7HII ܲeKBB–-[6~*TqrqqIJJ!88eFEg삏@$tTfUC=C3gjUlDQu PZZl2"Btta@.$;MMcy1** -[c8Y}J8(y >ɹ|2y>YN)㄄J;l; B"Z,QϜ9C$I|Ǹ:DIlAj&_| <`,OnPN 1c \H5?BQI|CQLX(,1APH4)))!!!/2 %}Fmj9 Sއ1{lUŋZշo_JYdai0? 2oP$i9eRg/QY{߻~ h̟?2:.'YhƺU H\}б8r’)Xݠ#Q'R%@27:E^( Š %d2u-88iܸqk֬),,~ j&˿vmd͛ͭOA'O޽{_%G(A4uuu1^reFF(/҉'MOABZMT™=ʕ+wp@7oޤI:X]jʔ)oߞ;wn~f̘1bĈŋ)`+J$MuuٳkkkƜ9s̙jĈVx)Ȇ+9(xxС / PmouT %}裏{Ǐ)LG`8)cP VUUoCBjIy,nn$ +8+\$M^HLr1cip$IbkkkXXXϞ=H(HP` *ĺ EQ}5ʬ8KoP h.\ؿŎE)CkpHa*uK~JSRgDѣG[[[ii) &M+mR\p`CVspU+~$"⚈JB֤C...6 mݺqӦM&yX$LF ;Յ %sZ~\JTiؾlذ!33bccʸhJZH@)))...|wΎ---X,/^>;{P,gϚLतh*x1:rT0Ņ&L@[lpBzz1c222.^x[eQA*LQ$I[lٽ{^JNNZsNg:ʈNH?7@me$ \wY 7nOznjc4ϝ;g4M&Ӵi6*^Ͽv hii  L#Ftcǎ[VS{-XoFĩK*P5%I 4hPzz޽{׭[Ч2cgE?@pǕ~b?ǡ4W^:u믿(E=ZlZH"ɳK,_~*5uQUlEhh( BmwE%aaa$ݻwKbް/pppZu \"]#< [{PvJ~,ώAؽ{X|vp[zo0/B]Uhp[ JnPEy:JvPիW^Z?i8o8 gWSUyRT N})8=r%kzSr2 q:qGT٫$5(sWj'MS/lJdw2,2/)T;\e$5ǠJx%"6 WjBq=`uHL:"ػܱf^rGu(ID ſOz)?hF*ݻpȑBJd~~ee/.7ǡg!.ݺuN߿.^H}j$M̙;ɒʂsQrzz S >}zLLL]]K~ᇘaP0s&ٺ1-vDDV=գGGGm4322,Y|ƍQ(ɘ1bЫW˗/3fݺu!00aaaTߨ<@'%'''44W^inn ;p@CCzg5,C Gڵko.,,߿ÇF#zۊTԸ:N~!ف[nafϞ]^^D:);0JSOVf]5//Ν;C  ݻ3p$I;U E ill\dIYYٌ3ط?JS%JPt0!%IZ?KT &G^bGdv}$L&BQm9ł8q"<, V̕3g|׍7nR SO=`Xl'RVR/PDoF\… x TmܹV֭[T"KƑ%Rߧ=j8+Bdd`y6)8?C{'O$ĉ\(`W#]$It555*_"< |ldPP"&NNI( 6B1؃Almm6l9V䉾ȹQcjeݠtȴdCH"Cq1\Q](1???++ :^Gz-d`@S(.* =A@%666._|ĉl a_ ;wKe˹˭P:+6`8zWpŢs(REAUrfw)@9XE{Dwww6FcnnnlllMM UAo~KTHQd=VP˗wmZwލ\4.&AH>~kk+BqY}WoEBV^ļg{DӻwjVزejܵkj;w.bgh!ˠy 111&i?~PPbgj 06icv>@ AAA\(gΜɩ^`ABBB``z3cp$x-P#I,)Sdgg[,e˖8p@EbgjU"?%;@FEEt:773f8;;O,B)wH͍8;;Ϛ5kF$jk.qP 4nnn/a؋ǏO~')hD, K(}7հ0Il"vv&dJP{t#ٷ(9`Je%fee_b٤MS VY;E}z=PZt8ĝݽdʔ)4O;~ZZ}sssPP"tJUddt_6|M$??5 裏waSʦEM1V{V:t( %0ɈҪN8hs;<'vzC(; Y1 sjll|cͧssw J$V]r?f[Stq*A~O=e(1z§$ Twd]cbp_ ư>}g]JpLc6Z-~-wxpX+SPcC&+v,Q%ȅF&N"vN%{3!- mgň%%(7"" ](((_Vl޿? :U3o&`"6i۷o;vL7o޻wgvVӐm&Sy?TUU X]]m6B.EtJĜӧOFtuӧOر#)) n߾}Y )X8!Q"WAbbb+ccc 99իTP1^|8r#Gg<'2Ji]ǧ5:::+++"" `0.U]MRUWsB qrr***Zf 2kvSΟ?jzxx0 '"[}o Vٳ ?M'|tfΜ lPα*f$ gt @;6n68MXP_,+MTTݻbaO*C#R. d0(*(`j>$` L?`qҖCQ|(9+VLP>}fѣG477`# 9Бp2.ِkuRy&;dpE=ypN"A93M8*XUU>DNR$!Kxd17&B21O!@2e>ȖyBK-s[ c1yyy ߴRոJF9˼u6jKZA^ J!uf\ '|;~6!UVG])P#GfbX7g9TDF;0"ߙb;0+P<{{~9]͔4ӦM=z… %I*//Ș3g˗u:ݜ9sH8Ul[G}$O@9p|HAZԩSO<~^=*(HL4ܼyS$''~RXƟUl0b;&''… >(m۶Z޽{;v,<<}jO 5āD+ij(R+PȯǛ7o5jT~~^x}jL* Wzwڴ'!Eܾ}{~~;u떘ᑛ  L'_]"Ky+FՖ^bg(**BzQQQXVV>\şړpgfb5Μyn< R+e~~mdaoFt*Gvvv޾}{RRŋcccW]PRjj`8"xyqrhN\\kPPb纺;]x3nMMMMMMz?_'+WZKIs}} +-- 쳛6mZ>|pxxHgQTYPN{Fpɂ 777:f HQz)'2O43#)Cnn{PPPkk(ޓ'OFpsjH aer foo>}L4)44Y)k@]6>>MsoKoÎI,\M%%eIykO Yt_#/:RW㞊---%%%III蜝/H D J%lt T'0-,1[8,;KXST;RQҸ 2 wHtL?n,R$Y(/+BA(RE-J((;ƾSQ½*I+\@u nwT?{رcWQwBczơ3Z- 40uT58˙k%(iiiIssqw @A[U f֬YZLJ`ALܿCdHC3x)'s-BW,{~}.B l4ӧN#uTa}Qk+h%pZp%jPV[!!!T][M hUX47o B,..NMM}'Ϝ93{;]] ´$IǓDs8y$*aLmpݻwy#G#((Ƞo 6[&4oZ9%H 0Q "ISO?4޽{/fmIhfJE3y z H}44\9hEpzxyϚ=MH(LF#fkjjBJ[nt?x𠓓kYYEg"FQp @T8C!vrv޽~< %/lLeM^`HWw䌌%K>|nKa\ot7]n㠒h6eF f<5 @~~~:eҤIfn7f(mw/9t)O$B`W޽{k4A:Ȑ@{@N^(I Jtor R̖K)E(4b\H66+@`0š;+B3)"1{H(.f+%Pa>A Pdg,+DU_%ͅɠS B *j:jw>u'x10?d (N}/qəÇTINN/<8$h/IE:N1Q':CW/zkOv MоEv@HJ k( z1d8ӂ8&ۋ*$3YE J+1UY!i @ s4 SÉO<5/1HS`hlm-h Խ{:EJСCM֫W/t*77w \re3dr9sJAȢ"t#^QXb^M#z F8_zxxpr%$$L6=##|:7^21[7zI5,j9hO>ο벲2//}„ : Ir}*i)eoشiSEEEllg}=j(>> ܘPqʆnR![Ź}}^[o[||ؕS $wM\=.ٳSNmllDlZɩb;HHew\'=8b6~^I [ FeXhTN,,KeeeTTTRRҠA lc%fLJd u ll|PdX}t`v@O^=zSFF~Wr~@&791ad)H.eP[y%zPH|;v$==EE@L&6f4Fc'j#f혲w `HHQN5!CFm`OWc|20PrQov,&H0@д˫ CdJBGk,#|)Q"9jL}&%$&DG;EvPxܹy汝aH*tRHuӱusΗR+VhS\ 'ce$ h(ѣ'N8f̘9sP___QQ1bĈÇcs'G .FUUU!!!Ymm-tdkJK٫d@3VhJJJDQtwwai?,7Ta% ';r)Sh4oׯ__]]}_=??`AǛ‰<nj{)//?~ /PRPWu!m$gKjY /`ƍ999LS < `8@%@#@/. 77Vĸ`0TWW744999$\G[h贲R{UWW 0!2&$P ܫ'|ʍEFw$xJKKuܼ}?y$fNQ!岬ĩD,Ic%I&33s̘1 byft7l6Ϛ5'HJK1Whld~U*H]Bd4 _駟Vs``J51 ;BR"]*%߿_vqWWf$pNJ{g}jF B-@wIt\% 33sӦMׯAѠ Zu/j?YO*]K]z~PKQQ_/٠ TOTnxvaҙWv $%n&^%SJqƍ7mfq5q4#(t EWPغ]n'mNbc`0ۢJ+nfW= .m5 @(ukEd \o,:3fDB n]/Q \Ԏ /t(z2P_{b}"79!;D` 8 .QVgKiFn.$euCy筭:o߾ޏ!5 qU"rftN%%򠱱h4VVVٓ?$^)d ֖p1 " ?y0>---wqq)--%MDCw[O $n F{9Tz$ ~SΟ?CsN/lW\y61L:O?o6l`6z뭼݄Z#@suuu,BM E)))djf:3)4+@whѵp#GzzzYfƌO?kq~0JZ[e+W^ޕWgVg:tK;+gPCOIrssEQAߍ#yAϲWt tTvvvCCCnkMguQ/|pJ(Zׯ_ZVu+V@/~:gॗh.pϼ"NTXXH>Y_WWG=o66zNpG555FQ"\ziXt:$4YKMM` Kl6dJ*++- Y=77`0t{*FI?>jI$f,4LUUUzʆCə3g/_~94Hm=\II rʗ^z4Ǐ?'CjժM6[n ʎf裏%t)==}͚5o6| &>\l~{׮]VJLL?>}:**ҥK$Tiii&?e˖!OŲv#M[ :uJիW㏵<11ʕ+nnnw RRR PXX~6̌8qbxxP "Ν7o޹s׿zdZї%oݺo>|}}+55ܹsfݺu ݊pBppl裏ԅ 233ƍw&09rJZ~8sŋwڵvZPr@nnl駟VXʓuVQQqmAz}aaWyyyQQ~>x'^~eX֝;wgѬO>_8}TB/Ktttzzz}}?7}sΝ;^{wf̘1d___OO'xرcfY>7..hĉÇojj ٳgEEŤIsss_x斒@C4iR^^===޽ꫯN2Ew}wY|o߾}ѧiYYY%%%VuȐ!۷o/..~ǽV#BCC}||"""v=|#88ȑ#5}#G544۷o͚5ӧOOIIYjUMMSO=ګW{o߾iii:ҥK>>>HOOׯ_XX.Xf577ō;6::ZZ '/gL|UTj*RfZȑ#3<&%%]xƍ2d^$ȑ#)))[nE/$)>>ԩSƍߥ?vuu9rdQQ*<~8zYfn۶mը$!!!%%eѢEݺu۱c$Immm)))!!!lUUU]Xcƌqi%h>>>/~ǎֆԖ.]KkoذaÆ 6-???>>+ZVE&LpI )StnP2ŭ[`0߿Ϟ= IjMLLf3`X-[p~0//_t7m2z=fV$555>|QڹsL85cΛ7/<<:_|ϯ@6^BΊb-))9|~ŋ\e?ř3gN8ѫWЧz*88'sHEٳg6gΜA<`ٔnr{N466:t}?pFV(B18v_JX]]U[[snݺ=Ҩw:?~ǎ(Λ7… [nEqy(3> endobj 391 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coveragedeaths17.png) >> endobj 392 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 393 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 392 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16853>> stream xy|U?}# [@XduA"U_u+*V[,VAv@IH ;ٓw{ܙ9'l9ϼ=<̜9́bzjt:͛dɒ3g 111qqqׯ-ܢi|q)AM84z΀JJJyޫWDBȬY ODbBGOG`lw)7=R2юsss=ʟR{%ϧ ݻ+** *(d1(n7L盗R*w )E :\^הPTB(J@]vҥiӦ)L9 O1PdbA e9s̡CltN ]QUU%z7V/ 9EZ oxi\WBCBB?5 RP z"C˧Ό|Fu+/~ܹsPrA]lr2ȝ^k?٤$u %pJ25/ 3OR=;-|;A r ԣ CǕϫ ҥKgϞt=L8@bb0GYI^d"ԩS`̜9sȑq\4\UU5{욚1gΜ9sFp8x :qYyGנBs>CxС<]%>f Pg={3={pd(O/KYn%m^L۷o:t(! Bo3H`ʠ L:F )r񼦠gzD-MSJ$%As7P+!t:Y׭[ظj*Hv%"2cܐb>añ}Q`) ,/^aÆRzӋ€}]ʔu???{ΝٰaCIIn/((,E ޭt7AM&*Qf5kڵh޽.]PPpǐ4{uW /C{=!ᄏzM [Vǔ-ė+@)'zP;;s:ӦMׯ_ccti)olz쌚q'NۙNbb0[]XSOM=(Jȑ#CCC̙S[[{]wS\&R{Ue_ܣGŲl2pBĉv;}:50ͣs"eyX7yM@Ub:#+C !1MyJ`^K(*MVȑ#$É[_ 4{P¨ JES$JGw~xz enhhիWCCp  /DF@AY*Z;~TOXd -C9)]lX L*++۷c=2pu{ X@ ('BysQ,/=Z'\P戈ѣG7{{ĉEUWW?F婮KSJJJ~Bc>Plz^G:?tvv&$$Ϛ5KzP$GER2]zJvCeee;6;;ui/ c2^Nآsڵ7onjj>~YYYyTT]{vxx&_J e>~i~߱lկXɓ'?#]{|4O9IQڋNP ,eĈ˗/jMDdPeSab0LSo6yC^oc\H)((mÆ BI&z% mH_e-A{$! .$+cPy˗/ˠ#5VW*{S(UP2w#v*;; 6L[FR /FJ"^V_ @p @VF2z?cOCA>;1>,߿?O[;Sn ĻOPf\wC7hz ɉw07CUK)d)~[R/כ!ƒROt e3\@y⪄m`+-BDk+ +A鹺n4>Z%5eBol֭R~q!k ]p!-- Ν;^GF^7zO?gGpoJ"BzW/R׭[gXu[nky"#lڴI3fYW^G?f͚-l23iȤI߾صkWpp~3####;;{…Nr P @=z8zرc}[1B絁@<׊s痛_yĈ_}UCC۳Gh !%Xc%gX,N8?^z;v舋$JJ7yW ={d2?tΞ=LwRa̧o?MYvs΅2W^񑑑3g qx2ʎnМJ(%B^^ŋ.\XZZ:sLy'YSG;/GR H>k9܊<{2|uuuR0/@ %% w%''Kx %(\軡^1"4@gLxGe#to22 LD9r #^;x=(0Qvo^CT|Y8 Ak r)B?0"KJ(ş$)c(heezWF?A4#+]^ViH /HY+J< J9|((ui eZh}j' M`Zvs mq=yAJS3šjcYyCq(ѣGv:33wߵZiiioVSSz@Zn3"߿>hll|vڥ*03 ^z)33^:y򤌩gY :P^ztMY|999/_NOOg@>|x֭|D5ҜBsa5U)Ś5kJJJ6nn޽{߾}xlB j׮]yqqMQjj*$TxJcd:t({Up$&&FFF;Bj4kC&!366O>Ce;+ߕ65\aaaYYY ,`788x֬YÇd}+Rr gIMMvgm,eO;3gJNdz%%6v@^B,KuuuZZAფ қ*GJDYWBDratNu +LÆ (X Tjt4@*RVC 6JC0Rb*ϡA/6gL.]b[p_êg$Y]PJe^fYV1=|u g=v/i %; ŋT(3>}zwlӽ𴣞j%B.?λrbk=6+V[r~llo J8%!Ŝ|a"WZ)d0i? X""#vt?׌D!{D%# 1p?q`hOYf/^XdIqqÇ.8:nCr;BܐRzرW.Z?g . /ɭgs 0ŏ\2{=$%%}GPHM0ƬPȪ*`+k:M69s̳=䚼7Ȥiy5ktvv>|˖-͋L8/gn, $y{ǚ^ٿnnnUUw(~ VOvB7&J X/0uԘ#L&n'\D@AKь( O˥LTE)5KK̠J(smmҥK}+VHB -"CIΤJEy>i({D/݅\RMYE/WKӟzV.,Ϻ@)QUAm6[mmlwFGhjnPz@Ųdƌ3f(nW"#fJ*nZin+"@)#^.p6Z~;X]A 55Č?>""rӧxJ)R3LqcTU=pȝ+xÏ?X^^~w>}=]"c4QBYlvwNf (yϟ?wiiiGPq xyb/L}GG;nݺ|Izz:R਋"M>!d͚5l 6?@ii pۉ eJOG_9rUVUTTs zQ"-k2ԩSlcg4h ޽{TWW#% ~H:߿W\>|8{7&&!+o8A!]݉й !ѭ))).]?~ 4btizSXXb fЧ~.Λ7pܥtȳt 0]L[n˱T(y6lؿonCO@Ð}KJI4y䎎\*ç1 K98k.F>^7 QVOp`,B$S'X [ LcƌILLlnn6+D1FрKH*&G$2!R1NtSy(]AqFPj̕]”m`kãJى?NYɑj_[-ylabڞ\:.}̘1s,;;{Μ9GX,s;)]G9kH9Ay !999ӦMۻwo@@@l2߻S`O>m6322fϞ-(AeaQC2:t(66xSSSϝ;Q]]m작jJn y&@ W~w}^;D%0{sI tl6[`` {G8ZY (G?*hĕP]2;wvv666={\uݵ'|A|/C+< ū޽k/ \LC<9!cW^]z1xJC"\+Ν5k֋/ M<裞l*,L,d4J裏[tݵ|-\~yfv๱8#U dTw,ԠLŋA`z(6r㪡;S#"D3=ƞ th~饗^z%U}AHQC 5>T'61?zKvOJBVf HNꎢgUڊ<3*tb~<7~W! IWPMTPfaƛ@\* UV(#W,:|<0=|0ك4}MY\܀@hP 1YsO g$r]WȤ(vV"NgX@PGR ^T6J؎XUN0.??{g<;DWnOȒQF>}Z^i)ݸD 2>|&/BEEoFfx9 ~+Xy@d%\r۵kWvvSO=UZZОx9ooGzzzqq7yNIIɪU6o\YYkUV^)6gdTxslslxav-Z$@Y1c_>==ڰaC߾}ӯ_ uәoG[ԥ[ZCBxJ~JJfOVksssUUjmjjϴy60Q,B._\RRez7J/?~rƌ.\7n'xBX Vo2dt:}||ab;(R9f2onM6XԻYS,ZfԈjM\#b0wUP”X>_2z|jsIS6pJ&#heY ↡X!2%(P#GtҚ5kZZZ =5^_΢Lo?>;;#G֯_oۻ"TXNMi % ;J+WE tY;_ӧw}WXXȾ +0{)ïR2dSO=URR2f̘;v P( g\C"n42zP)x^eFVT5l(FU#n$@L^+'1oO>ݵdt%4_Q_g"xFj]f\c(\lS!'BΝՄΕxP6TB/Az4gXzPPRAQ'MMMl!{ĉE>}z…Y$ƣ:ud[l1bDhh\1 =L `Ve x瞘wyy2Y ̡{a(k׮5jԶm۾)S?~<,,=(,!)y}N*񖗵k׶ :tժU3go~뭷E 6DAAh6'؇>%Odd$SL!577:tL_D Hm"+ a$///$$$>>d2DEEM2+P'+P X\@FIqÇϛ79**gϞ7|sRRR<1HaaڵkO~hl)x-4xվ$wnÑ'j*Z+Y6{ٳ'99(K)C)uL---`,&8U7xp!RY.OW;1QRJMaV [GK$Urf=) 8((H3%:|.VP %+J8+G/vPG, r5TTTTQQa2^I(6MϠ<=T%zվ.Ѳ8N$ZJ:\SS\,- {OJfpM7ݤ=Bkvv%& 4y^_;^ҭ}{.޺|({5'Խ _x Hr…o}Ν.r:P_/|45c]gAP ؀.O?t޼y}Yםr2fh2Y%2L&ivn:ҿ[WTTX;jg5yxf͚^zm޼0|{ОL|:Sz>.y^A]{B?p;vt}70}*\`(D9lǖo)44*v,LMTzAdddllf4h{&44̓Xy=LY#.qk~wنcƌ (((`4Jpt24(sQQQYYYKK˂ @Њ=G4_v[߈zrhʴi#l/_>| _PTm'Nl_=MJ+U퇿ɡޞ6vcQziv{bhc\|BG)<+s9((6StttE)moookkKd. @)qZOA8` tز%n TQY[{ /6QBɽKۏ4#$4mڴ{W1ъ'o lm.Xa0tOV0n"N a⸄&8)(CJ/#ڠW(uGq5&YgƗ?-0(kצ>5>TB&G6][@rhXZ-I;:vAg%?v(A`E[};{[Fhv4amsb'`N&N43YkvJƁ^СCOޣGv2//oƌcǎM8*ٿ?96'9J#qwԷyCUbG޵XB=2pוZ3ZC2-} dfEUSğP+%-]Tw=}~ko{;;C)#tz-{'!M$\&1(SAA p֭[ׯ_bB BtthDEO=2Ky-ywzVzתz뭣GX"A-<|5`?,LՀ]*'AH(a[lYrj}g\*b?BFE (]eޥXځvlMȰNgkkkmmmCCOuun]G]mi&7#DH ]XaB8ەx{{ٳgv{򥇘(X>J4I/e6mAk ՃU0ͱ2_)Np9q:斖&[o{1 pX[:)-'d VxqS;sҥهI#`%$(&G ɳRuXtXK@d={C6Ռ.~L yJc?e)w4F^NBX5>jhP?J&RNW(-rÕ, {R[SU| #"gvyDG[^zjU EguF0?0V}&dЁOK]Ə>y ]w ). {!),@Aض--* G" m4&`$!%8]43VU2%7+'` @@@@kk+pc"~D(A|)eWc{T/mKAz ^|Y L̔nV"}?7!53Q%1*@{PZNa 0uq+)) lnn^~kw@i Hi4;_(XQ뺝.VF͇q/;׿5sիWv뭷6C0* fvi4Ji!c*t:veЋ]:~/~QQQ"#voBxVl: Li(!UXmV%ź[ H4T_~%!tٳ$_FB 8K nQ'Y+W\xqժUfshh_PPPxx߼0õ} z(mb&J/=p5KIBCC{m%l40VRD%J{*fR b&4pFeȠ=zW39YPZͱb7@_/lpTͱ{骼+kJ!vpR!vJAC Bnbb| X ỳulᆭ'berڃOrPicg8=X¬QrTW<$%6 6 Pz6JہO79^׿&H`.VPړ@JnݟBBgv(A@'h3%6] j`"KH)5`!=@JX<okl f*ܵZ%Ai6!czX8D AU,uI-e|țDXցh)rSDV4У(~1ًPJ}lמQPCp g08Z\ı: ii||lL67_ol?WUl=H4c5W]jeN}N{طo_Qjkiٝ۷oj@:@:IД+V̜9xǏ I)ΐB+ V7DjzUWv؁Օ֖ٔ~˗[bU,6 Ѽ.7<9}@?p8'Ot8cK,. =f5oA]1ijj*,,X,VիxN)6O6\l9b[quuuGG央b655ivbh Sөi 䔊 gkooX,/_nkkӲtttXVs`mm-äf񉝝T(Oބ]ф|A߿xvej/b^sҥ?x}}=o?_*''gٲeVmn:r; 6꫌;bŊ{Wpĉn*@=_|_wnٲҲN[~'4+g~'O>rURR2}t7|GaSO=pA+0Ӑ---3L˗/cǎdgg9sfȐ! W^}\xq۶m&MJNNꫯXފ 6\xq%%%ƁWjjjhaɳgرc{|+33졠gϲC%$$lW_튖x񢏏ϸqN>ϟ?{;w.]m`=ЦMz)p4J<駟.Y$33gdd㏄WFDDj/{O<^p86nسg˗?䓬ə5k믿+"}FN9)))55n5kVmm0a e;85uԄǏe˖Nsٲe;w|A7==[n7nܐ!C(;w===n뮻Qʕ+|+WPJښZZZe555;vxWZZZ>Ç+?{ 7o4i-2k,SO=p䧞z455A9JOan>۴iSuu|7{nhhux㍩S QYAuuѣGǍx{D@hoo}zӧOn RYy6--m?p]PP. endstream endobj 394 0 obj << /Type /XObject /Subtype /Image /Width 62 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 62 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 399>> stream 8c`0b ul;7c B*fm &Aɚ3Fx5gMٴƎ c`rH f: Dy\( o &sSsm BǷ\8$@9܉ljG39RUwAFg*~:DP%b& MU, J\9"DY8 4=t$; Q>Ӡ~sHn9%$S pD@( JADzǀQ־$ HYzy10DaCL CB;вYu$I 'TKClŴ&v}JY\l,5t%g:`E+M*"[7JH. endstream endobj 395 0 obj << /Type /XObject /Subtype /Image /Width 62 /Height 18 /SMask 394 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 62 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Oi  & endstream endobj 396 0 obj << /Type /Annot /Subtype /Link /A 397 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 573.5550 147.7500 686.0550 ] >> endobj 397 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coveragehospitalizations12.png) >> endobj 398 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 399 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 398 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 15819>> stream x}yXaPdQ **உ{\h&In5Y,,hbEju 0j4.(Qe}daQLQ]U ~<<<էzԩSzzz@ӽ;vX,ek֬ILL|222}كJ$I|*Qf^ @X;F)]%ӦM[xqJJȑ#ׯ_;:uR6P¬;F*B(^fksΘ;w&$$8J]4HFi„)xJJP@cǎ+W<3!xwSRR{1WW=zL>: I9$Lע|VWWKꫯ-Z4ydF˥3::?piie˚^}U???XbO(%,T$IK/kL8qĉrhhlr cS'Z*h:o<|:fʢHLj>ۋuZM K믿OB'Odt> i>t*ap-dh4Νc*7]1 ]r7$:]ZMnVShu }B'LO*4enP߽{wڴi 3^hrvL塘BPYȀ@:JbL*`Ρh222/]2lо%Z$`NEEE#Q@ف13Hm%(ڼ@IuvvѣG7?Vlu}q0H1yatiB:DvZq fs:@F(|=zt~~~QQДA mb$<4q@)U`Lɘ[X!,h(VB(׿~͛o߾VVV՘|Ad/: ~MO>駟}7t%\ZK$>g@D|k׮Im۶ׯ2`e)mnn;vݻwŋz˗7sUq[žʈ'N$$$@LLӧڢ(uh 紒hV{uuÇccc322 ::lfx2(qۛL&lӵkצi4{ԩS^eZ HO 胵ksҥ@mN(Vn a5u۷o/\p3g5jTUU+਒+J$mEEży󪪪ϟjԨQfDm +(xŊx!'=az%QOh+A1ү_?LqBn3hˏ92|p.)&JX`LhzDlgECdJyr2(:%I%((EH[WATF9eWP!U(ڈ )Wf% 䀌-P!ҥK}||zq(_DSUdەiXKYSCi^x .3T/ jSd #astܐ.'|a-iFZJ W^z郍Rt4Okk| j6+~$*̪=ug:T4=zX,(99y׮]z~&}@xL ?E|rddl>r۷*4&c/46B}ٲeKzz:DFF޻wO/F4+a &55511 ;vsNFFFdddqqd|CKTg$Tt(3GqCǏ/,,<}ݻw &&̙3y%=qVm i I!SN߿?77%%%}U.b=fJ"Bs綴>,X?׫lUiGL W>20w܉'VUU=CXgѢEs`*?ׅ"pPpԨQ{?~uuEz=Xbʔ)ĸGQ;0(Innn:nݺuXuʕĉM&]AMy&ζ/"> A1%.ML4 =Θ[Χc:"mP3fLNN//$KB JÍbPLWa"\애p>4iĉ[ >}:+) !B&XA+dZacZ|MΪ|udw1clL48C_NRLdfz("~?(zͰb+1(cgX߿SO1y 0ݽo߾ngIDId%:PXp IoHHHffhphlmm>}y$CFM/0*3 FJKKO8l6OཕLRR !ϳ hkJ4x`??ԟ7tS92+ܠTUvڴi^}UL=_z5^=]BĮҢ 0Ls. $);;KEP|zR(]E 'Ӈzo`Hv6CgϞz>221231Җ>?34t,CvܔO 1;sv(ׯ_TA\4acK CLn?U>XB>ヒ!UAf͢[7&'WM5?ޫW/[FcBBBZZʕ+nܸ1lذ% wСYNZm4Ho>Pdk!xyytfOO!CDDD8;;< 5k 0*)ӧVtSLݴi#_׮EPԺs޿n˗/ѣ-kȼ 4m ϪkGt[fWP hSbK n!* ̱:N%Jjْ:Ct (2oCi_\\A|#Yh8˜f&MX-))?'On޼`00JTh g%(᨟8qX7xܹs >.ctQ>ʕ+!!!o`>tPiiiPP7& t<I$.aB=z o@z`4cA _Qy|GFGa+JP]RhEEEׯ_饗njSXX?G;B.,))5jn2GݻJEEݸq c}Ihlnnn(AE5553& `…EEEK,Q( FP%'''44THT" Q ёݝ^{ M<)K/}ގxG.V#G"WDy5 .<>~1CȫԡH4{l|&I~vn pImmȑ"/޺ػwoE[Hf+E^z<*T&qeH B>PaDH!M/%///'PGeP>...4V<90LD<DiU m0R_SWPpAUASїpB0(zrO ,Y )Hec;w/Ϗ?NfV{~3YU{%%%Լ{O|#׉t Jӿct:<;vΎۿee%(@=g!?\x(F?"""66x߾}C)6Iouҟhy鎊"\Vm~xWLjXWD%fEc(!\B˗/Wh4`}%*,l KHHxG ի]]]`ŊJ] h_{5 K.]lpB|-&F%t.*K}fcY#?ɷtX(EkߟWbJ{]fk :IO}[$(muJS__3L4W!#z C g TFZ\Š݀Yֻ 5L:چ"ފ*Udm\%gv UTGJ쌿Ҿ[јɼD/wO{+WDEE樨(/ 1)2@Q%!>,;;!_} +Qejޫӧ? ;w4Ǐ߿l^p˗֐'ڥEH2($Oz ""uȑŋ0obeIijj:ri?ꩣӧgX]VSʦEڶ6r>} 9V0|N~--P[q( E (D\(j м{$IVWW]ڰa͏@ʙ2￟D?]YWw~Yf1 39;PJrרB1i" wKipIHڪɫmC:[餕v0apIsyL@$ 0qWki#(: JNN?wT&B$,Yמ7ox ؼ^蒌vg]{ӵuuX;9(`]=-b!Ο'תWMP`&Q灮 t%Ħtƅ`iIڤ$b"<`1әEԫp.p=ƹΫQn*SRPj}VҔ 9d䐲D:ȊЄ1q.4ɡ<+tG EN_R2#j lh_yVqXL}9k /OJ%ӜY]@*566;vLj%:GQ6 V9fuNTڏwg8ȑ#z36Ku(C1$Iڳgϫ䄟ɂtH@b©$Q$Jol^zߺu ?g3gn'@5@ @ @5@alEEEy f~3H{I fU/C%h4:4??ǎ!0 'k 9hh2JP!;w̙i&l>SO@Pgf8Y_ƌYYY--- ?Ca=f (T݉QQQ9kș҆90G.)0tr}gju:]zz͛7mdK" r;3a!O-N{#'zs? AZj2HF[}{=%1%BG_ԘB.=Wxb;6A)) %d{q&JC$L_R-B]\Dm"+PFGߩ}uH9u8r0EѓR-W. hPJ.K(VD&UqE>nӍjXuec MY|HQ8"8x*@Q(:0y&BƋV%Lj+OshȞ!Ty&ypg*F,C1rҥf˗O_V2rJ o/"//ﭷ:~xZZƍms]ݝ%wzT2qqq]z~Z\\}͛7bgRի\ \;tpˆN%88~Ϟ=qqq+V4h+*i`0;Jvvw[7TӅ;Ӂ ***7oLק֮QI@Kmm-B(;;7pT>OC*׮]+//1cFJJJYYٸq WɻA饗^6BbX[ ,Bo#b!4 WL&$IB-0 ڹ#C,ӴUaZjHju(V"kU( G*IPǒ\"g>/4+<@tJX`;a:\TTwލy -Jj>_EXrLNNNKK={LN0iSC1./;wmvR]Pvӎv;quuxbHHȦMxԩہt.0 {{7=zjذaL ?"Td|\UUe6SSS/1oii Cl_*...**~y8lذ={_0BQ\\̔3U&]Nw!TTT`֠ Bjmmų1:XZ#_dMZ7n|^%1L|yY_׮uXY~Z̶{rafaÎ=:|%]NF +Jٯ_? PHHHffh mii #hb0 I5jN9s&bƌ|uMQ~,˃>XSS3sL>  8F tJ >׮]k6n3tdC”PL{wpӦMCeeeɋY-2FŤ^ xzÆ ۷o:w\8y򤃃V+<?#+0>Bchng,^/j .j4҈_k.Ns!;;;<#TyZB _lEjGDD?**駟D`iU9Єn\(qڵ+W=zn`ˡ!g!J|Z,&qs# `yP544tȐ!ᱹy nn}$y܄0>d2fzh}$J}jkkфZ ¤2&̀..='ba2_H蘛 . C9"$UŒ~(j%%%˗/zh,^d2ξPPPP>>>rwzz3D?~n߾@VV;,)Up9)+OpIgpvWKlYJ"P:+k׼׬Y.X8 a[\ "l-PqI%JXqBDyTYYiXÏvĜUK]|%AD#*E;eʔÇYp.n&! ̂F{` _͚(VZf)XB2#vPbZBS1mmmrk(JO Q^RTr`~Zpt|8*+0G@P^JT?tAFXVf6@h_*C!4Ç>}[>jiBR!adP޼y ߿o܁Ҿ:$Ђ$ P^-"n111x'uWbJ^` BisssϞ=Isww?&Nʡ 2xya+?`OoH2dP^hK){+KKK###?9s3NWQ[TX j IPs۷o׮]{7x ۺ:vKqy$6^ӀFo'Biϟ??mڴzl>R]]]WWgggWYYi2>FYOR~?Ivy믓jk·Ξ=@y [n7//o̘1&h}bʝ2 DRX_Ӆ&,<<<..///ٹ 9BV@2k{j"$@cmss3& >>k6=<<3  PA2ֶ]`_{M(xTN@'_Y^p!dee1x0 G{xd~n~$!p?nlh>lɓ'==٨ LI rgB͘U>X(y.]RlXc)/<^&s{ח^^~Lq具^ա~+W_Ue%]e>!* +IZr' Cmm1p@lgg @Ҷ)(YYk"_fj M7?e3 j /`(N& ^S /X.lF*!foPvyY,%HN*dTf D1ЁA<>_S iSKJ^^^(?@:µZ/餉O{}eR@.mN851_Ɯ"W[Ḵ+maaFpBLL̢EjLӌS@ *v4N@d2ĊWc(55.XXT7:6xquŭ t.<ɛS%nnn ,0`@rrN6lXZZZjjaɒ%) ::zرs̩6&LAp N_Ś:ukpyRRҺuhMŲnݺcǎO<wC7.00Acǎ%&&ڵo$566>|̙3ƍ?daaaG.(('O/eIIIw^~=.ILL\|޽{%INLL?~nXBBBnܸA[7ZEENJ+~czjժ,Z:44[lٲeb=|pUU~ ~,S8qիW%I;|7|3uTA*::70 駟UA$7ߴ &iK.:t_ srrzUVnmmmhhìJƒGbJShLō;vѢEd?m۶_~+//O$^L΋d***:z|W_]|Yl0ӧO3QQQ&M5k֜9sۍ7\244tƍ4?Qȑ#yo ?0`@]]e˖S2(/ arPYYyʕq=3:`0÷m+W )fkkk]]]TTԴiӖ/_~a%{ q}||> endobj 401 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coveragedeaths14.png) >> endobj 402 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 403 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 402 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16196>> stream xݽytE>JBHI v" .3;ΨqmdPBAB$d!FvrQ΅Y~tWSo[}aX};ñhѢ+V$'' QQQ[EQEq0* 2TL1cƢERSSjժ_|1%+P;VXf͚䰰7oܸ1))IǁB"Gbbĉ'L@8p`TTѣM&}q&(&zp(F2_~aaa]wu]7gULegc/qb1SeX\\l2I;waàM,jX[(TVV.[/ sGGǗ_~i< 8Yzu T(Ey6P 1KPff2:b WF5;zD{ѳ)6+ TFF9tP=p(쩋U%fdSS ju()ӟ 8=iR1wibqc(5'@ʔ]-;~….ݬzKhMV ^m\oxZK,wjLNN>zAdl,'XU1%rW^F_j.PR]-R]-}$4\WJ2o5j&WFʕWE;0|pE"O qA6]LF/**ӿub*?YCqi)N %%C҃2{{{GDDPӧO/O=T~~S/^\[[~pUU@;y \iiSSSy-[ 2$<<L(--՛X({$کZ"F@wqɓ{Yf@ Pf#E$N՛ 8(sdd+W}||rssmVUU5wܸy@W|f$֤mIs}ϙ <==oƟ~iĉ]m=~Wt%=uP1Bq\ S\]R(2̵62~衇M&?|ȤP +fqB&y衇jkk}||n0F9{v9.,u לTӧ;wn…={ȑ#xHCZVR(see󫫫Ă ,X@aȑvE ӾEQ^zMVi0L= O>=hӰ4k+6L}]tt4?\3NP%nB yҊ"ĂpP,T .FQy`zK L#FٳN>A #27}T :(. $|m 0O`IEJ0閽ZdׅqғBcPG}ՙl*Ú^A1ҫѫ 2P%)Dz|DW\l;cѣGKKKqq1W\X=+ɰEpEB5^KT`9I 0q~ _ɹűJILf]paӦM---֭i#єX J8(رc[l}ݹs8&R}\>ǐ-¥k^x-[JJ|܄`m]ʔAׯ_-[l\`?(Ԍ*-57NL$ʍQ 6㏅{ ""$5^tʔ)K{9 7Gm& b,uQ(JQP{ZT4z蜜oF8jC&A )Ժ@LstL$=ewΙc9R|.-zl1b̙3EҩNth)B+6jQ(ﵸ(i-k+c1)O)xqGP=7Urs~Ѡ(0vA vϩBWsP4"TWWZWW U ibgbr$*02nso@3j]?ъ V޻wZQk8'/pSP.gcѥs9e=zovYYYߟPUUu=t[_'}m 9ӧO/Yd׮],s@8Q_#""Ν+4KXL&$u"I 0??믧7n}^;v[[Ç۝K{^M[Ϗs<8sۆ#G:lΝv=22 Xj՚ob\x fϜ93--mǎAATPnZmJ|3f<3#OA?$w7C]s](*a|` 36_a^)WBGڠlf(rL_\\TSS#""2fIy1*KII߿7hmmU?W@9zP^駟Ey:srJ8kr{WDz:qرc{ְ={1B\Bp@6v],q8(BGVVVTTc=fZG{:g"C J,hXΝ0`޽{ZJL*ꫯ (**:{d0a?~iikbO?h999ϟ:thhhhxxx``ٳJYttJ}K̞=[Eֻ$1׃?h7<jJ$"^l U_mm-}%*Bqu%8p &&&44+ʸũ(蛡^>*T@[&!w el"Ci+PR]@8P@Hg 4Y]tԲ'ōT&ҡ?2]JH -s\q>n4YI@qPD{Y cK\$97` % LQ}Y^:,5yNGz]7"U|"i&l)c(!5R2ҡ#1ݦ1пضI;L-q)m3n'I@bPj>f12zSRR466&$$ "ipС?ժJ9s1fX_NII}O:%bGLE(Shhq, 333/]H7:v؞={*,RB5a6ծIņ nJ89;p۸ ԏ?XVVcǎm۶;Gv?-q16q5d2EGGWv{ddd``رc=<<>)w\2 !!!!;Kޥ>c%R={LKK뮻uѣܹsAR %Tmm5kv,Nx:6Sl\[(1;T WPb>?"eX,UUU q:u*w|_߽Yr@RODk:L=mxNP<9]DzYb]I~iРAWDRͨPe˖IMMM`@a(8&R+FgtIS77JjC*yhuy ޮD&T=5fdd-8tbN+;A! ).g̰00+¤e ңp EףO>ګW%le_|9H^bUfLVh$r 1QMJ${P̥n"SLLfX,WE@XV<ȻD }lӠL !DEW eOKզ~i[[[vv-[j[47V Y?Q{ZL4ĉv=66 WP__o 1Et!O>B43%k hJ e ظqn8qmv… sss']14bKSiuÆ Ç߹sE/e %+m3;"p$8=Vq|СŋLJD۹{4մՕ @iVeҤIt>}zfff[lݻM&SdddRK6)9)S,ٳL:ҥZ"2(~ 7 80**l ;S.&_{5*$JŤ=p.G4r}PX $(Lnp@!TnzPŋo߾ ӋY$u,us^[(ΌT(i>^wm/Lz@C(SGGGMM-p^lͻ%5sw723A:&P(OZ988x„ B^^ޙ3gnEQ%K zl 3sQ);EQΝ;WVVv뭷9s>]$cdRR(i] P7o^xq߾}FV=IO7P٩\-UzeYYYsMVkTTTrr,YRRRV7wY{s✤87lP__?f̘-[̛7o%%I`Rj|C7gΜYf|@2T`@dE _.\A̧O;Ӭgee7++*88 Ij m\ P__7|p*opp00Ndeei׻2d;ݻwssܹs322&LPZZ [1ͭ੧{TEv'tg߷o&7yvೱ?қoIe̙ ;; }hqww׫9x~L[yI ީNFXz$PK28dz[ǹ"OPV/&S8Bu|e_%ӕ-$D%=3fa.E|b'G'')(Q_/@1*3vX=N>P%c%QhF>6-,k;Qf*-}Z'6566&&&۷n ]BCmnQ!u:FwvVt66woYugI(c{c,@NfU1+=2GDD̜9s̘1v( ,8qbYݹk.$ hWt)@{UYSS3cƌzyyۗ$#Gi} uD3gΘ޽{'%%͟?_[ wګzG >*+sVVѣG͛G/|ա?SLLscGٮa#F;.TvDX_r?^ ٙUcf-K%KhlH⚼y/;!!8 `Uihh(k/DSj-d!7 t΅_=KJJ菫II ApݠUgSw9i$vR4 !EEE5Ȩ$j@Cl*+j6cܮ1?ˁ3SR[[۠Aׯ_777;7vSYYy<|^ mhxRy=ͨϟ;wK/D~I#]ZO]MMME'z7Zֆ\x+Q366h7vBўYm  1$ROMŋo񆔫Ye˹Z(a'1+qؓR/:kLټJ207WW|d"@T&v'H~E2\(V/J)]VqdV".e <.o nc v\ȱ'g&!0Hzivˮ q7AfEVzJ ̡(`+`EbchY/>a`丸}MMX5_ #lziպ!m RbSMuuuAAIjkksrr&L . ܽ{~eU1Y\\\__?jԨ3gП e {+*PDJM'NѣDZcƍ_Մ B>[YV] !~a^^??^$<;4[nʂM} U/э{uVTT÷1֤rR3Po-!![w1t1cƸo޼911{ݲeKwuY&q~ HK) `+y7]JkYZ̙[ccjllllhhꫯ$=bt+WB.]T\\ss=זNy…tǏ߼yf`1U1gҡC***ϟWH&uUP;ȑ#cǎ}饗w@n'QK~b{ZZСCW^]\\`Hp7L F6!$++kiiiy[[!M z ȧNڽ{w[[ۗ_~,m g.RL8wAI|PTTG鉹h쎚Pf??}VWWS75*..￟6mɓ'{I8$m8qrP\ڸqcSSSttufϞO$$$p l\=).ȑ#.\(..֭[gۇ wޘI&ձ*^4PntN6RZZjZGkkĉM&ӝw}"@B \ }}}ÛM&ĉMF+VKW lcǎ-ZjgԩQQQTKFĤVKɘ`qqqtp{K{"[w (''/]b3 K"A]"1驹(11;lf|x/2[r;/Qt O"@}>PK@[!P--$Ο:ydRRRzzҥKqx>,"=mUI1@ P Mˁbh#2 8…X,S޽xm\S uYRhנEd͐H掎GGG7 +N!P[Ij]֛';ߖOAJ zS)@75kWnnnPPp#@}7Q" ;bNE׸(F]he.,,,--mjj뮻<ĢEl6/@3(> EfSBkD-H׭[GbbbYsIJV瞟?ESz2hNDR(ɓ'VXh4񌞁C ii%vKZ*P֒DJ|l!v3F7D-|x0GDte6mZ\\U?*{ҩۀ&7}c D[5 %/LݯP !>~h:~-B[[[wE7v֛ 4Բ,Ž| qNT* JϓP?|(Ŗ%X‘Qrp;;r{}PrUwyx{xzzR_f>>>3f̸];iu}uQE{$XJ%-"ܹ/zgt i?qpǴ.M?0 Q1M[](X# l6UWE/epiJz5P12c7 XJj^;`F(Jq\c9sf^hUTT$&&cqZvRcW)IMB.nnn3g\|YOL $U&7ȴkV*>>ә]tu]KHhMH/ :P_~E?SSSٳyf(ɉ<}i B:⠸nݺ7x>q(697sܹwmll|^ThuZ>6۩+ŵ5jk|jkkkP_uƌc\SSSWWVUUeـVg*&U8YhkkٳgFmـ&(쾦76|ʔ)8I讜8_MA&D?DK7?n`6ѕmm$6$l8̉'&$$ŋsi b D(U]99`6@Ay{zEyBgc<GŇf ^%iAU\FQƮ}ylOޭ4h3Ua`!$/uPi+FL1cAm Wߒ ;pz/9y̘1nnnAy)Ӧu*+]Neq z3;{ѣkWRBϪUJ@od;)AHUɦӧ@E[ۈqг'|zP 1gѰ̅mmm~~~,3pNd9R PZg8L3ݼܼA q#U!B[qZZZ(B#U{ᗒ`8In5RЍU***8H؁6&[@ q*P_vЎ0dzfh )JrsO&544l/h؄WVbL[oϑ K{-.,; wJ3LÇr-"Lوҥ@*#"5ɒBwne8bʨ>@gf.}B&f6(JWcTRfRr羳@PͅgZUH3A3`{1cLIHa[ù+?'\… IIIfG}[oeffVUU97v&-&$`"!E-8(k֬ZqKKscgps,rbZ@5}i x͒;-,{oʕeeeYYY?,Ւ4,X :5oYX P(@:YJ&BBWss3Uhuuukkkeee]]݅ ܜ;w֠j C((J_ 8Ģ(MzZ^^N)))tRee%!Ĺ.r&E"} I"]A~>e(x4*Vujun,R/?Y 7`n/yH'b8(|űc>cThnHGG 7n-iMk̀?E$d P (,kkz v{XX؃>X^^$vKC_BGH%0u;wYPĝb'0B===90Q8JBBB| @Qzqgǎ73;| !P !漼/[^"f1'E E)ހqz}H9_:Ռ&gvyF'`R(!՛PXI!=rE 0yUf}24ـ2E)<)KW)ti/Hª@bb< Ħ( (}x)]ŕ$QYq%( &j= ܵ te+tQVz *d&ɂ) ^rEikx[j89bECIB PB`1Rw9Vr)7hҡҵ]_3a#ݝހ!2RՄ&. #W6E:^$$Hšt hY9?rmq{S(89ߤ֖\:q `g3yo&º^F@l%DQzRLQ:UY^ͣLe] TpDwg؉ҪA6W/K@gv_&+ )z+JbWa/SH#^a#PQ*777[,}^rE (dF `(t2F!7=okk .//Ij(u)W (S$JW\\Q\\oB*9{]a%LSz뭟ȑ#J^^߾J/{S3iαӑeEk2fi3fx뭷>裵kvttbÇ kkkE/W@9 Hz45g2?Ә3`,M "Qzٳg}O? sZJ9:IgϦyy@Y)J?W;SCŋ6w@ ٚfEfggLʬ,-[-u|ˉ_̬ ٹsGpppw)%YULd2vSvn_x+\|7Jf}mm-v|GGGEE<}n{]bposo㪪6IAlEѾ_WWgZmjmmes*)w唗l6xvvvkkbtRKKZQѾ>_SST^^fWTT(wvTӅl.:thJ^z?EEEC=_rUg}o]ruֱqqqAAA6m*زekF)KiiiO=? ^{^xom3g.]c> $$dΝ~u8?͛wUK _h3ղ˔)S?BϜ9j[˖-իWGDD9rJjvb(?LUV}g4?!!~JOO-HNN:th]]]~~K/DwŸɓ'޽-//߲eŋ/^\\\Li>|[n9|#<1QB***Ϟ=ݻ>rap8Ξ=Ko=z4""#==^PGx񢛛.\o߾znСC{mV^ 8ؾ}+RRRh~RRRBBwYYٹs! K?裏[gժUO>$233Νo^}U.'ΤvܹsҮ\_̚5k… .|_xٳg:488ooll駟:::jjjk׮ɓ'>1""b„ ={,++:ujZZZvvǎ//d//shNse|鄐_|^X|yppp߾}iEEEv}Сaaa7o.,,[vȑ#z]RR2a„Ç/ZGr{=jԨ삂;w>SfJNN^reUU՝w٫Woo߾.\X,Ǐݻ!C7b/r8V5**j׮]ƍ;wnMMn4ig}e8{5}􈈈'O+WcʕꫯZ611رc{?~СCEٷo_rrM覿466Ǐo9a„QF t 7|V9wu_|(JKKK\\\rrrddĉ{QQQA;vӧY-Jݻ{뭷7٬|MMMLL˗׮]vZÑW]]MҦPJ!!!_o(J^^^\\?ӧ[Nz׮]=\kk~_(v=!!gGG+`ٖ-[vm 4O>999<Dy744n6`(Jcccii޽{)[u|{{]veqr-111w}'CBBEiiiihhhjjbkf.**ڻw﫯;vL*g|wܱm۶*=y [WWʬ]v\8*&zPUUuĉ/_7Z[[Lr?-]Tn1bccg̘q]wSS__?`od )3mOcEǓVŋ dɒ#F7꠽o`&ާ8tЁzURRuwFDD\dI$ 믿_jkk1bĂ ܿk#ClN}}>}޽cs!VI~駙[n6(^ﶃtȑ/d2r-Gݴi}th@>̌)SDFFҭ8WJ A@MgΜ4h̙35@ K/$$$ 4o2\(, v endstream endobj 404 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 391>> stream 8c`0b p@(mftt,[BH d>(k> Ys) 'S0lQJgbhCTƹ6w!~$,`sI H_s3z**E*P-@ 6m NPLTUHy@bR$-cٯqHq"f]0VA\=t@ǎaC!l)++;ה>(!m9%$SŒ)`@(4,@sIcB׀T@I?KO?&s3lxvbaBZ609ZK0```/SX) D?GV$1!_Ҕ"\ =" endstream endobj 405 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /SMask 404 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om_x \ endstream endobj 406 0 obj << /Type /Annot /Subtype /Link /A 407 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 154.6650 147.7500 267.1650 ] >> endobj 407 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coveragehospitalizations14.png) >> endobj 408 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 409 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 408 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16043>> stream x}yXG沨 "(\T5!dL4ƌ$3j2$O2YUd2jb45.#o]r-}>[N:v_to͛m6f?+RRRy_|q$Id#J< UcuN:w>|999'(uJ%R*g(̽{X7HII ܲeKBB–-[6~*TqrqqIJJ!88eFEg삏@$tTfUC=C3gjUlDQu PZZl2"Btta@.$;MMcy1** -[c8Y}J8(y >ɹ|2y>YN)㄄J;l; B"Z,QϜ9C$I|Ǹ:DIlAj&_| <`,OnPN 1c \H5?BQI|CQLX(,1APH4)))!!!/2 %}Fmj9 Sއ1{lUŋZշo_JYdai0? 2oP$i9eRg/QY{߻~ h̟?2:.'YhƺU H\}б8r’)Xݠ#Q'R%@27:E^( Š %d2u-88iܸqk֬),,~ j&˿vmd͛ͭOA'O޽{_%G(A4uuu1^reFF(/҉'MOABZMT™=ʕ+wp@7oޤI:X]jʔ)oߞ;wn~f̘1bĈŋ)`+J$MuuٳkkkƜ9s̙jĈVx)Ȇ+9(xxС / PmouT %}裏{Ǐ)LG`8)cP VUUoCBjIy,nn$ +8+\$M^HLr1cip$IbkkkXXXϞ=H(HP` *ĺ EQ}5ʬ8KoP h.\ؿŎE)CkpHa*uK~JSRgDѣG[[[ii) &M+mR\p`CVspU+~$"⚈JB֤C...6 mݺqӦM&yX$LF ;Յ %sZ~\JTiؾlذ!33bccʸhJZH@)))...|wΎ---X,/^>;{P,gϚLतh*x1:rT0Ņ&L@[lpBzz1c222.^x[eQA*LQ$I[lٽ{^JNNZsNg:ʈNH?7@me$ \wY 7nOznjc4ϝ;g4M&Ӵi6*^Ͽv hii  L#Ftcǎ[VS{-XoFĩK*P5%I 4hPzz޽{׭[Ч2cgE?@pǕ~b?ǡ4W^:u믿(E=ZlZH"ɳK,_~*5uQUlEhh( BmwE%aaa$ݻwKbް/pppZu \"]#< [{PvJ~,ώAؽ{X|vp[zo0/B]Uhp[ JnPEy:JvPիW^Z?i8o8 gWSUyRT N})8=r%kzSr2 q:qGT٫$5(sWj'MS/lJdw2,2/)T;\e$5ǠJx%"6 WjBq=`uHL:"ػܱf^rGu(ID ſOz)?hF*ݻpȑBJd~~ee/.7ǡg!.ݺuN߿.^H}j$M̙;ɒʂsQrzz S >}zLLL]]K~ᇘaP0s&ٺ1-vDDV=գGGGm4322,Y|ƍQ(ɘ1bЫW˗/3fݺu!00aaaTߨ<@'%'''44W^inn ;p@CCzg5,C Gڵko.,,߿ÇF#zۊTԸ:N~!ف[nafϞ]^^D:);0JSOVf]5//Ν;C  ݻ3p$I;U E ill\dIYYٌ3ط?JS%JPt0!%IZ?KT &G^bGdv}$L&BQm9ł8q"<, V̕3g|׍7nR SO=`Xl'RVR/PDoF\… x TmܹV֭[T"KƑ%Rߧ=j8+Bdd`y6)8?C{'O$ĉ\(`W#]$It555*_"< |ldPP"&NNI( 6B1؃Almm6l9V䉾ȹQcjeݠtȴdCH"Cq1\Q](1???++ :^Gz-d`@S(.* =A@%666._|ĉl a_ ;wKe˹˭P:+6`8zWpŢs(REAUrfw)@9XE{Dwww6FcnnnlllMM UAo~KTHQd=VP˗wmZwލ\4.&AH>~kk+BqY}WoEBV^ļg{DӻwjVزejܵkj;w.bgh!ˠy 111&i?~PPbgj 06icv>@ AAA\(gΜɩ^`ABBB``z3cp$x-P#I,)Sdgg[,e˖8p@EbgjU"?%;@FEEt:773f8;;O,B)wH͍8;;Ϛ5kF$jk.qP 4nnn/a؋ǏO~')hD, K(}7հ0Il"vv&dJP{t#ٷ(9`Je%fee_b٤MS VY;E}z=PZt8ĝݽdʔ)4O;~ZZ}sssPP"tJUddt_6|M$??5 裏waSʦEM1V{V:t( %0ɈҪN8hs;<'vzC(; Y1 sjll|cͧssw J$V]r?f[Stq*A~O=e(1z§$ Twd]cbp_ ư>}g]JpLc6Z-~-wxpX+SPcC&+v,Q%ȅF&N"vN%{3!- mgň%%(7"" ](((_Vl޿? :U3o&`"6i۷o;vL7o޻wgvVӐm&Sy?TUU X]]m6B.EtJĜӧOFtuӧOر#)) n߾}Y )X8!Q"WAbbb+ccc 99իTP1^|8r#Gg<'2Ji]ǧ5:::+++"" `0.U]MRUWsB qrr***Zf 2kvSΟ?jzxx0 '"[}o Vٳ ?M'|tfΜ lPα*f$ gt @;6n68MXP_,+MTTݻbaO*C#R. d0(*(`j>$` L?`qҖCQ|(9+VLP>}fѣG477`# 9Бp2.ِkuRy&;dpE=ypN"A93M8*XUU>DNR$!Kxd17&B21O!@2e>ȖyBK-s[ c1yyy ߴRոJF9˼u6jKZA^ J!uf\ '|;~6!UVG])P#GfbX7g9TDF;0"ߙb;0+P<{{~9]͔4ӦM=z… %I*//Ș3g˗u:ݜ9sH8Ul[G}$O@9p|HAZԩSO<~^=*(HL4ܼyS$''~RXƟUl0b;&''… >(m۶Z޽{;v,<<}jO 5āD+ij(R+PȯǛ7o5jT~~^x}jL* Wzwڴ'!Eܾ}{~~;u떘ᑛ  L'_]"Ky+FՖ^bg(**BzQQQXVV>\şړpgfb5Μyn< R+e~~mdaoFt*Gvvv޾}{RRŋcccW]PRjj`8"xyqrhN\\kPPb纺;]x3nMMMMMMz?_'+WZKIs}} +-- 쳛6mZ>|pxxHgQTYPN{Fpɂ 777:f HQz)'2O43#)Cnn{PPPkk(ޓ'OFpsjH aer foo>}L4)44Y)k@]6>>MsoKoÎI,\M%%eIykO Yt_#/:RW㞊---%%%III蜝/H D J%lt T'0-,1[8,;KXST;RQҸ 2 wHtL?n,R$Y(/+BA(RE-J((;ƾSQ½*I+\@u nwT?{رcWQwBczơ3Z- 40uT58˙k%(iiiIssqw @A[U f֬YZLJ`ALܿCdHC3x)'s-BW,{~}.B l4ӧN#uTa}Qk+h%pZp%jPV[!!!T][M hUX47o B,..NMM}'Ϝ93{;]] ´$IǓDs8y$*aLmpݻwy#G#((Ƞo 6[&4oZ9%H 0Q "ISO?4޽{/fmIhfJE3y z H}44\9hEpzxyϚ=MH(LF#fkjjBJ[nt?x𠓓kYYEg"FQp @T8C!vrv޽~< %/lLeM^`HWw䌌%K>|nKa\ot7]n㠒h6eF f<5 @~~~:eҤIfn7f(mw/9t)O$B`W޽{k4A:Ȑ@{@N^(I Jtor R̖K)E(4b\H66+@`0š;+B3)"1{H(.f+%Pa>A Pdg,+DU_%ͅɠS B *j:jw>u'x10?d (N}/qəÇTINN/<8$h/IE:N1Q':CW/zkOv MоEv@HJ k( z1d8ӂ8&ۋ*$3YE J+1UY!i @ s4 SÉO<5/1HS`hlm-h Խ{:EJСCM֫W/t*77w \re3dr9sJAȢ"t#^QXb^M#z F8_zxxpr%$$L6=##|:7^21[7zI5,j9hO>ο벲2//}„ : Ir}*i)eoشiSEEEllg}=j(>> ܘPqʆnR![Ź}}^[o[||ؕS $wM\=.ٳSNmllDlZɩb;HHew\'=8b6~^I [ FeXhTN,,KeeeTTTRRҠA lc%fLJd u ll|PdX}t`v@O^=zSFF~Wr~@&791ad)H.eP[y%zPH|;v$==EE@L&6f4Fc'j#f혲w `HHQN5!CFm`OWc|20PrQov,&H0@д˫ CdJBGk,#|)Q"9jL}&%$&DG;EvPxܹy汝aH*tRHuӱusΗR+VhS\ 'ce$ h(ѣ'N8f̘9sP___QQ1bĈÇcs'G .FUUU!!!Ymm-tdkJK٫d@3VhJJJDQtwwai?,7Ta% ';r)Sh4oׯ__]]}_=??`AǛ‰<nj{)//?~ /PRPWu!m$gKjY /`ƍ999LS < `8@%@#@/. 77Vĸ`0TWW744999$\G[h贲R{UWW 0!2&$P ܫ'|ʍEFw$xJKKuܼ}?y$fNQ!岬ĩD,Ic%I&33s̘1 byft7l6Ϛ5'HJK1Whld~U*H]Bd4 _駟Vs``J51 ;BR"]*%߿_vqWWf$pNJ{g}jF B-@wIt\% 33sӦMׯAѠ Zu/j?YO*]K]z~PKQQ_/٠ TOTnxvaҙWv $%n&^%SJqƍ7mfq5q4#(t EWPغ]n'mNbc`0ۢJ+nfW= .m5 @(ukEd \o,:3fDB n]/Q \Ԏ /t(z2P_{b}"79!;D` 8 .QVgKiFn.$euCy筭:o߾ޏ!5 qU"rftN%%򠱱h4VVVٓ?$^)d ֖p1 " ?y0>---wqq)--%MDCw[O $n F{9Tz$ ~SΟ?CsN/lW\y61L:O?o6l`6z뭼݄Z#@suuu,BM E)))djf:3)4+@whѵp#GzzzYfƌO?kq~0JZ[e+W^ޕWgVg:tK;+gPCOIrssEQAߍ#yAϲWt tTvvvCCCnkMguQ/|pJ(Zׯ_ZVu+V@/~:gॗh.pϼ"NTXXH>Y_WWG=o66zNpG555FQ"\ziXt:$4YKMM` Kl6dJ*++- Y=77`0t{*FI?>jI$f,4LUUUzʆCə3g/_~94Hm=\II rʗ^z4Ǐ?'CjժM6[n ʎf裏%t)==}͚5o6| &>\l~{׮]VJLL?>}:**ҥK$Tiii&?e˖!OŲv#M[ :uJիW㏵<11ʕ+nnnw RRR PXX~6̌8qbxxP "Ν7o޹s׿zdZї%oݺo>|}}+55ܹsfݺu ݊pBppl裏ԅ 233ƍw&09rJZ~8sŋwڵvZPr@nnl駟VXʓuVQQqmAz}aaWyyyQQ~>x'^~eX֝;wgѬO>_8}TB/Ktttzzz}}?7}sΝ;^{wf̘1d___OO'xرcfY>7..hĉÇojj ٳgEEŤIsss_x斒@C4iR^^===޽ꫯN2Ew}wY|o߾}ѧiYYY%%%VuȐ!۷o/..~ǽV#BCC}||"""v=|#88ȑ#5}#G544۷o͚5ӧOOIIYjUMMSO=ګW{o߾iii:ҥK>>>HOOׯ_XX.Xf577ō;6::ZZ '/gL|UTj*RfZȑ#3<&%%]xƍ2d^$ȑ#)))[nE/$)>>ԩSƍߥ?vuu9rdQQ*<~8zYfn۶mը$!!!%%eѢEݺu۱c$Immm)))!!!lUUU]Xcƌqi%h>>>/~ǎֆԖ.]KkoذaÆ 6-???>>+ZVE&LpI )StnP2ŭ[`0߿Ϟ= IjMLLf3`X-[p~0//_t7m2z=fV$555>|QڹsL85cΛ7/<<:_|ϯ@6^BΊb-))9|~ŋ\e?ř3gN8ѫWЧz*88'sHEٳg6gΜA<`ٔnr{N466:t}?pFV(B18v_JX]]U[[snݺ=Ҩw:?~ǎ(Λ7… [nEqy(3> endobj 411 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coveragedeaths17.png) >> endobj 412 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 413 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 412 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16853>> stream xy|U?}# [@XduA"U_u+*V[,VAv@IH ;ٓw{ܙ9'l9ϼ=<̜9́bzjt:͛dɒ3g 111qqqׯ-ܢi|q)AM84z΀JJJyޫWDBȬY ODbBGOG`lw)7=R2юsss=ʟR{%ϧ ݻ+** *(d1(n7L盗R*w )E :\^הPTB(J@]vҥiӦ)L9 O1PdbA e9s̡CltN ]QUU%z7V/ 9EZ oxi\WBCBB?5 RP z"C˧Ό|Fu+/~ܹsPrA]lr2ȝ^k?٤$u %pJ25/ 3OR=;-|;A r ԣ CǕϫ ҥKgϞt=L8@bb0GYI^d"ԩS`̜9sȑq\4\UU5{욚1gΜ9sFp8x :qYyGנBs>CxС<]%>f Pg={3={pd(O/KYn%m^L۷o:t(! Bo3H`ʠ L:F )r񼦠gzD-MSJ$%As7P+!t:Y׭[ظj*Hv%"2cܐb>añ}Q`) ,/^aÆRzӋ€}]ʔu???{ΝٰaCIIn/((,E ޭt7AM&*Qf5kڵh޽.]PPpǐ4{uW /C{=!ᄏzM [Vǔ-ė+@)'zP;;s:ӦMׯ_ccti)olz쌚q'NۙNbb0[]XSOM=(Jȑ#CCC̙S[[{]wS\&R{Ue_ܣGŲl2pBĉv;}:50ͣs"eyX7yM@Ub:#+C !1MyJ`^K(*MVȑ#$É[_ 4{P¨ JES$JGw~xz enhhիWCCp  /DF@AY*Z;~TOXd -C9)]lX L*++۷c=2pu{ X@ ('BysQ,/=Z'\P戈ѣG7{{ĉEUWW?F婮KSJJJ~Bc>Plz^G:?tvv&$$Ϛ5KzP$GER2]zJvCeee;6;;ui/ c2^Nآsڵ7onjj>~YYYyTT]{vxx&_J e>~i~߱lկXɓ'?#]{|4O9IQڋNP ,eĈ˗/jMDdPeSab0LSo6yC^oc\H)((mÆ BI&z% mH_e-A{$! .$+cPy˗/ˠ#5VW*{S(UP2w#v*;; 6L[FR /FJ"^V_ @p @VF2z?cOCA>;1>,߿?O[;Sn ĻOPf\wC7hz ɉw07CUK)d)~[R/כ!ƒROt e3\@y⪄m`+-BDk+ +A鹺n4>Z%5eBol֭R~q!k ]p!-- Ν;^GF^7zO?gGpoJ"BzW/R׭[gXu[nky"#lڴI3fYW^G?f͚-l23iȤI߾صkWpp~3####;;{…Nr P @=z8zرc}[1B絁@<׊s痛_yĈ_}UCC۳Gh !%Xc%gX,N8?^z;v舋$JJ7yW ={d2?tΞ=LwRa̧o?MYvs΅2W^񑑑3g qx2ʎnМJ(%B^^ŋ.\XZZ:sLy'YSG;/GR H>k9܊<{2|uuuR0/@ %% w%''Kx %(\軡^1"4@gLxGe#to22 LD9r #^;x=(0Qvo^CT|Y8 Ak r)B?0"KJ(ş$)c(heezWF?A4#+]^ViH /HY+J< J9|((ui eZh}j' M`Zvs mq=yAJS3šjcYyCq(ѣGv:33wߵZiiioVSSz@Zn3"߿>hll|vڥ*03 ^z)33^:y򤌩gY :P^ztMY|999/_NOOg@>|x֭|D5ҜBsa5U)Ś5kJJJ6nn޽{߾}xlB j׮]yqqMQjj*$TxJcd:t({Up$&&FFF;Bj4kC&!366O>Ce;+ߕ65\aaaYYY ,`788x֬YÇd}+Rr gIMMvgm,eO;3gJNdz%%6v@^B,KuuuZZAფ қ*GJDYWBDratNu +LÆ (X Tjt4@*RVC 6JC0Rb*ϡA/6gL.]b[p_êg$Y]PJe^fYV1=|u g=v/i %; ŋT(3>}zwlӽ𴣞j%B.?λrbk=6+V[r~llo J8%!Ŝ|a"WZ)d0i? X""#vt?׌D!{D%# 1p?q`hOYf/^XdIqqÇ.8:nCr;BܐRzرW.Z?g . /ɭgs 0ŏ\2{=$%%}GPHM0ƬPȪ*`+k:M69s̳=䚼7Ȥiy5ktvv>|˖-͋L8/gn, $y{ǚ^ٿnnnUUw(~ VOvB7&J X/0uԘ#L&n'\D@AKь( O˥LTE)5KK̠J(smmҥK}+VHB -"CIΤJEy>i({D/݅\RMYE/WKӟzV.,Ϻ@)QUAm6[mmlwFGhjnPz@Ųdƌ3f(nW"#fJ*nZin+"@)#^.p6Z~;X]A 55Č?>""rӧxJ)R3LqcTU=pȝ+xÏ?X^^~w>}=]"c4QBYlvwNf (yϟ?wiiiGPq xyb/L}GG;nݺ|Izz:R਋"M>!d͚5l 6?@ii pۉ eJOG_9rUVUTTs zQ"-k2ԩSlcg4h ޽{TWW#% ~H:߿W\>|8{7&&!+o8A!]݉й !ѭ))).]?~ 4btizSXXb fЧ~.Λ7pܥtȳt 0]L[n˱T(y6lؿonCO@Ð}KJI4y䎎\*ç1 K98k.F>^7 QVOp`,B$S'X [ LcƌILLlnn6+D1FрKH*&G$2!R1NtSy(]AqFPj̕]”m`kãJى?NYɑj_[-ylabڞ\:.}̘1s,;;{Μ9GX,s;)]G9kH9Ay !999ӦMۻwo@@@l2߻S`O>m6322fϞ-(AeaQC2:t(66xSSSϝ;Q]]m작jJn y&@ W~w}^;D%0{sI tl6[`` {G8ZY (G?*hĕP]2;wvv666={\uݵ'|A|/C+< ū޽k/ \LC<9!cW^]z1xJC"\+Ν5k֋/ M<裞l*,L,d4J裏[tݵ|-\~yfv๱8#U dTw,ԠLŋA`z(6r㪡;S#"D3=ƞ th~饗^z%U}AHQC 5>T'61?zKvOJBVf HNꎢgUڊ<3*tb~<7~W! IWPMTPfaƛ@\* UV(#W,:|<0=|0ك4}MY\܀@hP 1YsO g$r]WȤ(vV"NgX@PGR ^T6J؎XUN0.??{g<;DWnOȒQF>}Z^i)ݸD 2>|&/BEEoFfx9 ~+Xy@d%\r۵kWvvSO=UZZОx9ooGzzzqq7yNIIɪU6o\YYkUV^)6gdTxslslxav-Z$@Y1c_>==ڰaC߾}ӯ_ uәoG[ԥ[ZCBxJ~JJfOVksssUUjmjjϴy60Q,B._\RRez7J/?~rƌ.\7n'xBX Vo2dt:}||ab;(R9f2onM6XԻYS,ZfԈjM\#b0wUP”X>_2z|jsIS6pJ&#heY ↡X!2%(P#GtҚ5kZZZ =5^_΢Lo?>;;#G֯_oۻ"TXNMi % ;J+WE tY;_ӧw}WXXȾ +0{)ïR2dSO=URR2f̘;v P( g\C"n42zP)x^eFVT5l(FU#n$@L^+'1oO>ݵdt%4_Q_g"xFj]f\c(\lS!'BΝՄΕxP6TB/Az4gXzPPRAQ'MMMl!{ĉE>}z…Y$ƣ:ud[l1bDhh\1 =L `Ve x瞘wyy2Y ̡{a(k׮5jԶm۾)S?~<,,=(,!)y}N*񖗵k׶ :tժU3go~뭷E 6DAAh6'؇>%Odd$SL!577:tL_D Hm"+ a$///$$$>>d2DEEM2+P'+P X\@FIqÇϛ79**gϞ7|sRRR<1HaaڵkO~hl)x-4xվ$wnÑ'j*Z+Y6{ٳ'99(K)C)uL---`,&8U7xp!RY.OW;1QRJMaV [GK$Urf=) 8((H3%:|.VP %+J8+G/vPG, r5TTTTQQa2^I(6MϠ<=T%zվ.Ѳ8N$ZJ:\SS\,- {OJfpM7ݤ=Bkvv%& 4y^_;^ҭ}{.޺|({5'Խ _x Hr…o}Ν.r:P_/|45c]gAP ؀.O?t޼y}Yםr2fh2Y%2L&ivn:ҿ[WTTX;jg5yxf͚^zm޼0|{ОL|:Sz>.y^A]{B?p;vt}70}*\`(D9lǖo)44*v,LMTzAdddllf4h{&44̓Xy=LY#.qk~wنcƌ (((`4Jpt24(sQQQYYYKK˂ @Њ=G4_v[߈zrhʴi#l/_>| _PTm'Nl_=MJ+U퇿ɡޞ6vcQziv{bhc\|BG)<+s9((6StttE)moookkKd. @)qZOA8` tز%n TQY[{ /6QBɽKۏ4#$4mڴ{W1ъ'o lm.Xa0tOV0n"N a⸄&8)(CJ/#ڠW(uGq5&YgƗ?-0(kצ>5>TB&G6][@rhXZ-I;:vAg%?v(A`E[};{[Fhv4amsb'`N&N43YkvJƁ^СCOޣGv2//oƌcǎM8*ٿ?96'9J#qwԷyCUbG޵XB=2pוZ3ZC2-} dfEUSğP+%-]Tw=}~ko{;;C)#tz-{'!M$\&1(SAA p֭[ׯ_bB BtthDEO=2Ky-ywzVzתz뭣GX"A-<|5`?,LՀ]*'AH(a[lYrj}g\*b?BFE (]eޥXځvlMȰNgkkkmmmCCOuun]G]mi&7#DH ]XaB8ەx{{ٳgv{򥇘(X>J4I/e6mAk ՃU0ͱ2_)Np9q:斖&[o{1 pX[:)-'d VxqS;sҥهI#`%$(&G ɳRuXtXK@d={C6Ռ.~L yJc?e)w4F^NBX5>jhP?J&RNW(-rÕ, {R[SU| #"gvyDG[^zjU EguF0?0V}&dЁOK]Ə>y ]w ). {!),@Aض--* G" m4&`$!%8]43VU2%7+'` @@@@kk+pc"~D(A|)eWc{T/mKAz ^|Y L̔nV"}?7!53Q%1*@{PZNa 0uq+)) lnn^~kw@i Hi4;_(XQ뺝.VF͇q/;׿5sիWv뭷6C0* fvi4Ji!c*t:veЋ]:~/~QQQ"#voBxVl: Li(!UXmV%ź[ H4T_~%!tٳ$_FB 8K nQ'Y+W\xqժUfshh_PPPxx߼0õ} z(mb&J/=p5KIBCC{m%l40VRD%J{*fR b&4pFeȠ=zW39YPZͱb7@_/lpTͱ{骼+kJ!vpR!vJAC Bnbb| X ỳulᆭ'berڃOrPicg8=X¬QrTW<$%6 6 Pz6JہO79^׿&H`.VPړ@JnݟBBgv(A@'h3%6] j`"KH)5`!=@JX<okl f*ܵZ%Ai6!czX8D AU,uI-e|țDXցh)rSDV4У(~1ًPJ}lמQPCp g08Z\ı: ii||lL67_ol?WUl=H4c5W]jeN}N{طo_Qjkiٝ۷oj@:@:IД+V̜9xǏ I)ΐB+ V7DjzUWv؁Օ֖ٔ~˗[bU,6 Ѽ.7<9}@?p8'Ot8cK,. =f5oA]1ijj*,,X,VիxN)6O6\l9b[quuuGG央b655ivbh Sөi 䔊 gkooX,/_nkkӲtttXVs`mm-äf񉝝T(Oބ]ф|A߿xvej/b^sҥ?x}}=o?_*''gٲeVmn:r; 6꫌;bŊ{Wpĉn*@=_|_wnٲҲN[~'4+g~'O>rURR2}t7|GaSO=pA+0Ӑ---3L˗/cǎdgg9sfȐ! W^}\xq۶m&MJNNꫯXފ 6\xq%%%ƁWjjjhaɳgرc{|+33졠gϲC%$$lW_튖x񢏏ϸqN>ϟ?{;w.]m`=ЦMz)p4J<駟.Y$33gdd㏄WFDDj/{O<^p86nسg˗?䓬ə5k믿+"}FN9)))55n5kVmm0a e;85uԄǏe˖Nsٲe;w|A7==[n7nܐ!C(;w===n뮻Qʕ+|+WPJښZZZe555;vxWZZZ>Ç+?{ 7o4i-2k,SO=p䧞z455A9JOan>۴iSuu|7{nhhux㍩S QYAuuѣGǍx{D@hoo}zӧOn RYy6--m?p]PP. endstream endobj 414 0 obj << /Type /XObject /Subtype /Image /Width 62 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 62 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 399>> stream 8c`0b ul;7c B*fm &Aɚ3Fx5gMٴƎ c`rH f: Dy\( o &sSsm BǷ\8$@9܉ljG39RUwAFg*~:DP%b& MU, J\9"DY8 4=t$; Q>Ӡ~sHn9%$S pD@( JADzǀQ־$ HYzy10DaCL CB;вYu$I 'TKClŴ&v}JY\l,5t%g:`E+M*"[7JH. endstream endobj 415 0 obj << /Type /XObject /Subtype /Image /Width 62 /Height 18 /SMask 414 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 62 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Oi  & endstream endobj 416 0 obj << /Type /Annot /Subtype /Link /A 417 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 573.5550 147.7500 686.0550 ] >> endobj 417 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coveragehospitalizations12.png) >> endobj 418 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 419 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 418 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 15819>> stream x}yXaPdQ **உ{\h&In5Y,,hbEju 0j4.(Qe}daQLQ]U ~<<<էzԩSzzz@ӽ;vX,ek֬ILL|222}كJ$I|*Qf^ @X;F)]%ӦM[xqJJȑ#ׯ_;:uR6P¬;F*B(^fksΘ;w&$$8J]4HFi„)xJJP@cǎ+W<3!xwSRR{1WW=zL>: I9$Lע|VWWKꫯ-Z4ydF˥3::?piie˚^}U???XbO(%,T$IK/kL8qĉrhhlr cS'Z*h:o<|:fʢHLj>ۋuZM K믿OB'Odt> i>t*ap-dh4Νc*7]1 ]r7$:]ZMnVShu }B'LO*4enP߽{wڴi 3^hrvL塘BPYȀ@:JbL*`Ρh222/]2lо%Z$`NEEE#Q@ف13Hm%(ڼ@IuvvѣG7?Vlu}q0H1yatiB:DvZq fs:@F(|=zt~~~QQДA mb$<4q@)U`Lɘ[X!,h(VB(׿~͛o߾VVV՘|Ad/: ~MO>駟}7t%\ZK$>g@D|k׮Im۶ׯ2`e)mnn;vݻwŋz˗7sUq[žʈ'N$$$@LLӧڢ(uh 紒hV{uuÇccc322 ::lfx2(qۛL&lӵkצi4{ԩS^eZ HO 胵ksҥ@mN(Vn a5u۷o/\p3g5jTUU+਒+J$mEEży󪪪ϟjԨQfDm +(xŊx!'=az%QOh+A1ү_?LqBn3hˏ92|p.)&JX`LhzDlgECdJyr2(:%I%((EH[WATF9eWP!U(ڈ )Wf% 䀌-P!ҥK}||zq(_DSUdەiXKYSCi^x .3T/ jSd #astܐ.'|a-iFZJ W^z郍Rt4Okk| j6+~$*̪=ug:T4=zX,(99y׮]z~&}@xL ?E|rddl>r۷*4&c/46B}ٲeKzz:DFF޻wO/F4+a &55511 ;vsNFFFdddqqd|CKTg$Tt(3GqCǏ/,,<}ݻw &&̙3y%=qVm i I!SN߿?77%%%}U.b=fJ"Bs綴>,X?׫lUiGL W>20w܉'VUU=CXgѢEs`*?ׅ"pPpԨQ{?~uuEz=Xbʔ)ĸGQ;0(Innn:nݺuXuʕĉM&]AMy&ζ/"> A1%.ML4 =Θ[Χc:"mP3fLNN//$KB JÍbPLWa"\애p>4iĉ[ >}:+) !B&XA+dZacZ|MΪ|udw1clL48C_NRLdfz("~?(zͰb+1(cgX߿SO1y 0ݽo߾ngIDId%:PXp IoHHHffhphlmm>}y$CFM/0*3 FJKKO8l6OཕLRR !ϳ hkJ4x`??ԟ7tS92+ܠTUvڴi^}UL=_z5^=]BĮҢ 0Ls. $);;KEP|zR(]E 'Ӈzo`Hv6CgϞz>221231Җ>?34t,CvܔO 1;sv(ׯ_TA\4acK CLn?U>XB>ヒ!UAf͢[7&'WM5?ޫW/[FcBBBZZʕ+nܸ1lذ% wСYNZm4Ho>Pdk!xyytfOO!CDDD8;;< 5k 0*)ӧVtSLݴi#_׮EPԺs޿n˗/ѣ-kȼ 4m ϪkGt[fWP hSbK n!* ̱:N%Jjْ:Ct (2oCi_\\A|#Yh8˜f&MX-))?'On޼`00JTh g%(᨟8qX7xܹs >.ctQ>ʕ+!!!o`>tPiiiPP7& t<I$.aB=z o@z`4cA _Qy|GFGa+JP]RhEEEׯ_饗njSXX?G;B.,))5jn2GݻJEEݸq c}Ihlnnn(AE5553& `…EEEK,Q( FP%'''44THT" Q ёݝ^{ M<)K/}ގxG.V#G"WDy5 .<>~1CȫԡH4{l|&I~vn pImmȑ"/޺ػwoE[Hf+E^z<*T&qeH B>PaDH!M/%///'PGeP>...4V<90LD<DiU m0R_SWPpAUASїpB0(zrO ,Y )Hec;w/Ϗ?NfV{~3YU{%%%Լ{O|#׉t Jӿct:<;vΎۿee%(@=g!?\x(F?"""66x߾}C)6Iouҟhy鎊"\Vm~xWLjXWD%fEc(!\B˗/Wh4`}%*,l KHHxG ի]]]`ŊJ] h_{5 K.]lpB|-&F%t.*K}fcY#?ɷtX(EkߟWbJ{]fk :IO}[$(muJS__3L4W!#z C g TFZ\Š݀Yֻ 5L:چ"ފ*Udm\%gv UTGJ쌿Ҿ[јɼD/wO{+WDEE樨(/ 1)2@Q%!>,;;!_} +Qejޫӧ? ;w4Ǐ߿l^p˗֐'ڥEH2($Oz ""uȑŋ0obeIijj:ri?ꩣӧgX]VSʦEڶ6r>} 9V0|N~--P[q( E (D\(j м{$IVWW]ڰa͏@ʙ2￟D?]YWw~Yf1 39;PJrרB1i" wKipIHڪɫmC:[餕v0apIsyL@$ 0qWki#(: JNN?wT&B$,Yמ7ox ؼ^蒌vg]{ӵuuX;9(`]=-b!Ο'תWMP`&Q灮 t%Ħtƅ`iIڤ$b"<`1әEԫp.p=ƹΫQn*SRPj}VҔ 9d䐲D:ȊЄ1q.4ɡ<+tG EN_R2#j lh_yVqXL}9k /OJ%ӜY]@*566;vLj%:GQ6 V9fuNTڏwg8ȑ#z36Ku(C1$Iڳgϫ䄟ɂtH@b©$Q$Jol^zߺu ?g3gn'@5@ @ @5@alEEEy f~3H{I fU/C%h4:4??ǎ!0 'k 9hh2JP!;w̙i&l>SO@Pgf8Y_ƌYYY--- ?Ca=f (T݉QQQ9kș҆90G.)0tr}gju:]zz͛7mdK" r;3a!O-N{#'zs? AZj2HF[}{=%1%BG_ԘB.=Wxb;6A)) %d{q&JC$L_R-B]\Dm"+PFGߩ}uH9u8r0EѓR-W. hPJ.K(VD&UqE>nӍjXuec MY|HQ8"8x*@Q(:0y&BƋV%Lj+OshȞ!Ty&ypg*F,C1rҥf˗O_V2rJ o/"//ﭷ:~xZZƍms]ݝ%wzT2qqq]z~Z\\}͛7bgRի\ \;tpˆN%88~Ϟ=qqq+V4h+*i`0;Jvvw[7TӅ;Ӂ ***7oLק֮QI@Kmm-B(;;7pT>OC*׮]+//1cFJJJYYٸq WɻA饗^6BbX[ ,Bo#b!4 WL&$IB-0 ڹ#C,ӴUaZjHju(V"kU( G*IPǒ\"g>/4+<@tJX`;a:\TTwލy -Jj>_EXrLNNNKK={LN0iSC1./;wmvR]Pvӎv;quuxbHHȦMxԩہt.0 {{7=zjذaL ?"Td|\UUe6SSS/1oii Cl_*...**~y8lذ={_0BQ\\̔3U&]Nw!TTT`֠ Bjmmų1:XZ#_dMZ7n|^%1L|yY_׮uXY~Z̶{rafaÎ=:|%]NF +Jٯ_? PHHHffh mii #hb0 I5jN9s&bƌ|uMQ~,˃>XSS3sL>  8F tJ >׮]k6n3tdC”PL{wpӦMCeeeɋY-2FŤ^ xzÆ ۷o:w\8y򤃃V+<?#+0>Bchng,^/j .j4҈_k.Ns!;;;<#TyZB _lEjGDD?**駟D`iU9Єn\(qڵ+W=zn`ˡ!g!J|Z,&qs# `yP544tȐ!ᱹy nn}$y܄0>d2fzh}$J}jkkфZ ¤2&̀..='ba2_H蘛 . C9"$UŒ~(j%%%˗/zh,^d2ξPPPP>>>rwzz3D?~n߾@VV;,)Up9)+OpIgpvWKlYJ"P:+k׼׬Y.X8 a[\ "l-PqI%JXqBDyTYYiXÏvĜUK]|%AD#*E;eʔÇYp.n&! ̂F{` _͚(VZf)XB2#vPbZBS1mmmrk(JO Q^RTr`~Zpt|8*+0G@P^JT?tAFXVf6@h_*C!4Ç>}[>jiBR!adP޼y ߿o܁Ҿ:$Ђ$ P^-"n111x'uWbJ^` BisssϞ=Isww?&Nʡ 2xya+?`OoH2dP^hK){+KKK###?9s3NWQ[TX j IPs۷o׮]{7x ۺ:vKqy$6^ӀFo'Biϟ??mڴzl>R]]]WWgggWYYi2>FYOR~?Ivy믓jk·Ξ=@y [n7//o̘1&h}bʝ2 DRX_Ӆ&,<<<..///ٹ 9BV@2k{j"$@cmss3& >>k6=<<3  PA2ֶ]`_{M(xTN@'_Y^p!dee1x0 G{xd~n~$!p?nlh>lɓ'==٨ LI rgB͘U>X(y.]RlXc)/<^&s{ח^^~Lq具^ա~+W_Ue%]e>!* +IZr' Cmm1p@lgg @Ҷ)(YYk"_fj M7?e3 j /`(N& ^S /X.lF*!foPvyY,%HN*dTf D1ЁA<>_S iSKJ^^^(?@:µZ/餉O{}eR@.mN851_Ɯ"W[Ḵ+maaFpBLL̢EjLӌS@ *v4N@d2ĊWc(55.XXT7:6xquŭ t.<ɛS%nnn ,0`@rrN6lXZZZjjaɒ%) ::zرs̩6&LAp N_Ś:ukpyRRҺuhMŲnݺcǎO<wC7.00Acǎ%&&ڵo$566>|̙3ƍ?daaaG.(('O/eIIIw^~=.ILL\|޽{%INLL?~nXBBBnܸA[7ZEENJ+~czjժ,Z:44[lٲeb=|pUU~ ~,S8qիW%I;|7|3uTA*::70 駟UA$7ߴ &iK.:t_ srrzUVnmmmhhìJƒGbJShLō;vѢEd?m۶_~+//O$^L΋d***:z|W_]|Yl0ӧO3QQQ&M5k֜9sۍ7\244tƍ4?Qȑ#yo ?0`@]]e˖S2(/ arPYYyʕq=3:`0÷m+W )fkkk]]]TTԴiӖ/_~a%{ q}||> endobj 421 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coveragedeaths14.png) >> endobj 422 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 423 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 422 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16196>> stream xݽytE>JBHI v" .3;ΨqmdPBAB$d!FvrQ΅Y~tWSo[}aX};ñhѢ+V$'' QQQ[EQEq0* 2TL1cƢERSSjժ_|1%+P;VXf͚䰰7oܸ1))IǁB"Gbbĉ'L@8p`TTѣM&}q&(&zp(F2_~aaa]wu]7gULegc/qb1SeX\\l2I;waàM,jX[(TVV.[/ sGGǗ_~i< 8Yzu T(Ey6P 1KPff2:b WF5;zD{ѳ)6+ TFF9tP=p(쩋U%fdSS ju()ӟ 8=iR1wibqc(5'@ʔ]-;~….ݬzKhMV ^m\oxZK,wjLNN>zAdl,'XU1%rW^F_j.PR]-R]-}$4\WJ2o5j&WFʕWE;0|pE"O qA6]LF/**ӿub*?YCqi)N %%C҃2{{{GDDPӧO/O=T~~S/^\[[~pUU@;y \iiSSSy-[ 2$<<L(--՛X({$کZ"F@wqɓ{Yf@ Pf#E$N՛ 8(sdd+W}||rssmVUU5wܸy@W|f$֤mIs}ϙ <==oƟ~iĉ]m=~Wt%=uP1Bq\ S\]R(2̵62~衇M&?|ȤP +fqB&y衇jkk}||n0F9{v9.,u לTӧ;wn…={ȑ#xHCZVR(see󫫫Ă ,X@aȑvE ӾEQ^zMVi0L= O>=hӰ4k+6L}]tt4?\3NP%nB yҊ"ĂpP,T .FQy`zK L#FٳN>A #27}T :(. $|m 0O`IEJ0閽ZdׅqғBcPG}ՙl*Ú^A1ҫѫ 2P%)Dz|DW\l;cѣGKKKqq1W\X=+ɰEpEB5^KT`9I 0q~ _ɹűJILf]paӦM---֭i#єX J8(رc[l}ݹs8&R}\>ǐ-¥k^x-[JJ|܄`m]ʔAׯ_-[l\`?(Ԍ*-57NL$ʍQ 6㏅{ ""$5^tʔ)K{9 7Gm& b,uQ(JQP{ZT4z蜜oF8jC&A )Ժ@LstL$=ewΙc9R|.-zl1b̙3EҩNth)B+6jQ(ﵸ(i-k+c1)O)xqGP=7Urs~Ѡ(0vA vϩBWsP4"TWWZWW U ibgbr$*02nso@3j]?ъ V޻wZQk8'/pSP.gcѥs9e=zovYYYߟPUUu=t[_'}m 9ӧO/Yd׮],s@8Q_#""Ν+4KXL&$u"I 0??믧7n}^;v[[Ç۝K{^M[Ϗs<8sۆ#G:lΝv=22 Xj՚ob\x fϜ93--mǎAATPnZmJ|3f<3#OA?$w7C]s](*a|` 36_a^)WBGڠlf(rL_\\TSS#""2fIy1*KII߿7hmmU?W@9zP^駟Ey:srJ8kr{WDz:qرc{ְ={1B\Bp@6v],q8(BGVVVTTc=fZG{:g"C J,hXΝ0`޽{ZJL*ꫯ (**:{d0a?~iikbO?h999ϟ:thhhhxxx``ٳJYttJ}K̞=[Eֻ$1׃?h7<jJ$"^l U_mm-}%*Bqu%8p &&&44+ʸũ(蛡^>*T@[&!w el"Ci+PR]@8P@Hg 4Y]tԲ'ōT&ҡ?2]JH -s\q>n4YI@qPD{Y cK\$97` % LQ}Y^:,5yNGz]7"U|"i&l)c(!5R2ҡ#1ݦ1пضI;L-q)m3n'I@bPj>f12zSRR466&$$ "ipС?ժJ9s1fX_NII}O:%bGLE(Shhq, 333/]H7:v؞={*,RB5a6ծIņ nJ89;p۸ ԏ?XVVcǎm۶;Gv?-q16q5d2EGGWv{ddd``رc=<<>)w\2 !!!!;Kޥ>c%R={LKK뮻uѣܹsAR %Tmm5kv,Nx:6Sl\[(1;T WPb>?"eX,UUU q:u*w|_߽Yr@RODk:L=mxNP<9]DzYb]I~iРAWDRͨPe˖IMMM`@a(8&R+FgtIS77JjC*yhuy ޮD&T=5fdd-8tbN+;A! ).g̰00+¤e ңp EףO>ګW%le_|9H^bUfLVh$r 1QMJ${P̥n"SLLfX,WE@XV<ȻD }lӠL !DEW eOKզ~i[[[vv-[j[47V Y?Q{ZL4ĉv=66 WP__o 1Et!O>B43%k hJ e ظqn8qmv… sss']14bKSiuÆ Ç߹sE/e %+m3;"p$8=Vq|СŋLJD۹{4մՕ @iVeҤIt>}zfff[lݻM&SdddRK6)9)S,ٳL:ҥZ"2(~ 7 80**l ;S.&_{5*$JŤ=p.G4r}PX $(Lnp@!TnzPŋo߾ ӋY$u,us^[(ΌT(i>^wm/Lz@C(SGGGMM-p^lͻ%5sw723A:&P(OZ988x„ B^^ޙ3gnEQ%K zl 3sQ);EQΝ;WVVv뭷9s>]$cdRR(i] P7o^xq߾}FV=IO7P٩\-UzeYYYsMVkTTTrr,YRRRV7wY{s✤87lP__?f̘-[̛7o%%I`Rj|C7gΜYf|@2T`@dE _.\A̧O;Ӭgee7++*88 Ij m\ P__7|p*opp00Ndeei׻2d;ݻwssܹs322&LPZZ [1ͭ੧{TEv'tg߷o&7yvೱ?қoIe̙ ;; }hqww׫9x~L[yI ީNFXz$PK28dz[ǹ"OPV/&S8Bu|e_%ӕ-$D%=3fa.E|b'G'')(Q_/@1*3vX=N>P%c%QhF>6-,k;Qf*-}Z'6566&&&۷n ]BCmnQ!u:FwvVt66woYugI(c{c,@NfU1+=2GDD̜9s̘1v( ,8qbYݹk.$ hWt)@{UYSS3cƌzyyۗ$#Gi} uD3gΘ޽{'%%͟?_[ wګzG >*+sVVѣG͛G/|ա?SLLscGٮa#F;.TvDX_r?^ ٙUcf-K%KhlH⚼y/;!!8 `Uihh(k/DSj-d!7 t΅_=KJJ菫II ApݠUgSw9i$vR4 !EEE5Ȩ$j@Cl*+j6cܮ1?ˁ3SR[[۠Aׯ_777;7vSYYy<|^ mhxRy=ͨϟ;wK/D~I#]ZO]MMME'z7Zֆ\x+Q366h7vBўYm  1$ROMŋo񆔫Ye˹Z(a'1+qؓR/:kLټJ207WW|d"@T&v'H~E2\(V/J)]VqdV".e <.o nc v\ȱ'g&!0Hzivˮ q7AfEVzJ ̡(`+`EbchY/>a`丸}MMX5_ #lziպ!m RbSMuuuAAIjkksrr&L . ܽ{~eU1Y\\\__?jԨ3gП e {+*PDJM'NѣDZcƍ_Մ B>[YV] !~a^^??^$<;4[nʂM} U/э{uVTT÷1֤rR3Po-!![w1t1cƸo޼911{ݲeKwuY&q~ HK) `+y7]JkYZ̙[ccjllllhhꫯ$=bt+WB.]T\\ss=זNy…tǏ߼yf`1U1gҡC***ϟWH&uUP;ȑ#cǎ}饗w@n'QK~b{ZZСCW^]\\`Hp7L F6!$++kiiiy[[!M z ȧNڽ{w[[ۗ_~,m g.RL8wAI|PTTG鉹h쎚Pf??}VWWS75*..￟6mɓ'{I8$m8qrP\ڸqcSSSttufϞO$$$p l\=).ȑ#.\(..֭[gۇ wޘI&ձ*^4PntN6RZZjZGkkĉM&ӝw}"@B \ }}}ÛM&ĉMF+VKW lcǎ-ZjgԩQQQTKFĤVKɘ`qqqtp{K{"[w (''/]b3 K"A]"1驹(11;lf|x/2[r;/Qt O"@}>PK@[!P--$Ο:ydRRRzzҥKqx>,"=mUI1@ P Mˁbh#2 8…X,S޽xm\S uYRhנEd͐H掎GGG7 +N!P[Ij]֛';ߖOAJ zS)@75kWnnnPPp#@}7Q" ;bNE׸(F]he.,,,--mjj뮻<ĢEl6/@3(> EfSBkD-H׭[GbbbYsIJV瞟?ESz2hNDR(ɓ'VXh4񌞁C ii%vKZ*P֒DJ|l!v3F7D-|x0GDte6mZ\\U?*{ҩۀ&7}c D[5 %/LݯP !>~h:~-B[[[wE7v֛ 4Բ,Ž| qNT* JϓP?|(Ŗ%X‘Qrp;;r{}PrUwyx{xzzR_f>>>3f̸];iu}uQE{$XJ%-"ܹ/zgt i?qpǴ.M?0 Q1M[](X# l6UWE/epiJz5P12c7 XJj^;`F(Jq\c9sf^hUTT$&&cqZvRcW)IMB.nnn3g\|YOL $U&7ȴkV*>>ә]tu]KHhMH/ :P_~E?SSSٳyf(ɉ<}i B:⠸nݺ7x>q(697sܹwmll|^ThuZ>6۩+ŵ5jk|jkkkP_uƌc\SSSWWVUUeـVg*&U8YhkkٳgFmـ&(쾦76|ʔ)8I讜8_MA&D?DK7?n`6ѕmm$6$l8̉'&$$ŋsi b D(U]99`6@Ay{zEyBgc<GŇf ^%iAU\FQƮ}ylOޭ4h3Ua`!$/uPi+FL1cAm Wߒ ;pz/9y̘1nnnAy)Ӧu*+]Neq z3;{ѣkWRBϪUJ@od;)AHUɦӧ@E[ۈqг'|zP 1gѰ̅mmm~~~,3pNd9R PZg8L3ݼܼA q#U!B[qZZZ(B#U{ᗒ`8In5RЍU***8H؁6&[@ q*P_vЎ0dzfh )JrsO&544l/h؄WVbL[oϑ K{-.,; wJ3LÇr-"Lوҥ@*#"5ɒBwne8bʨ>@gf.}B&f6(JWcTRfRr羳@PͅgZUH3A3`{1cLIHa[ù+?'\… IIIfG}[oeffVUU97v&-&$`"!E-8(k֬ZqKKscgps,rbZ@5}i x͒;-,{oʕeeeYYY?,Ւ4,X :5oYX P(@:YJ&BBWss3Uhuuukkkeee]]݅ ܜ;w֠j C((J_ 8Ģ(MzZ^^N)))tRee%!Ĺ.r&E"} I"]A~>e(x4*Vujun,R/?Y 7`n/yH'b8(|űc>cThnHGG 7n-iMk̀?E$d P (,kkz v{XX؃>X^^$vKC_BGH%0u;wYPĝb'0B===90Q8JBBB| @Qzqgǎ73;| !P !漼/[^"f1'E E)ހqz}H9_:Ռ&gvyF'`R(!՛PXI!=rE 0yUf}24ـ2E)<)KW)ti/Hª@bb< Ħ( (}x)]ŕ$QYq%( &j= ܵ te+tQVz *d&ɂ) ^rEikx[j89bECIB PB`1Rw9Vr)7hҡҵ]_3a#ݝހ!2RՄ&. #W6E:^$$Hšt hY9?rmq{S(89ߤ֖\:q `g3yo&º^F@l%DQzRLQ:UY^ͣLe] TpDwg؉ҪA6W/K@gv_&+ )z+JbWa/SH#^a#PQ*777[,}^rE (dF `(t2F!7=okk .//Ij(u)W (S$JW\\Q\\oB*9{]a%LSz뭟ȑ#J^^߾J/{S3iαӑeEk2fi3fx뭷>裵kvttbÇ kkkE/W@9 Hz45g2?Ә3`,M "Qzٳg}O? sZJ9:IgϦyy@Y)J?W;SCŋ6w@ ٚfEfggLʬ,-[-u|ˉ_̬ ٹsGpppw)%YULd2vSvn_x+\|7Jf}mm-v|GGGEE<}n{]bposo㪪6IAlEѾ_WWgZmjmmes*)w唗l6xvvvkkbtRKKZQѾ>_SST^^fWTT(wvTӅl.:thJ^z?EEEC=_rUg}o]ruֱqqqAAA6m*زekF)KiiiO=? ^{^xom3g.]c> $$dΝ~u8?͛wUK _h3ղ˔)S?BϜ9j[˖-իWGDD9rJjvb(?LUV}g4?!!~JOO-HNN:th]]]~~K/DwŸɓ'޽-//߲eŋ/^\\\Li>|[n9|#<1QB***Ϟ=ݻ>rap8Ξ=Ko=z4""#==^PGx񢛛.\o߾znСC{mV^ 8ؾ}+RRRh~RRRBBwYYٹs! K?裏[gժUO>$233Νo^}U.'ΤvܹsҮ\_̚5k… .|_xٳg:488ooll駟:::jjjk׮ɓ'>1""b„ ={,++:ujZZZvvǎ//d//shNse|鄐_|^X|yppp߾}iEEEv}Сaaa7o.,,[vȑ#z]RR2a„Ç/ZGr{=jԨ삂;w>SfJNN^reUU՝w٫Woo߾.\X,Ǐݻ!C7b/r8V5**j׮]ƍ;wnMMn4ig}e8{5}􈈈'O+WcʕꫯZ611رc{?~СCEٷo_rrM覿466Ǐo9a„QF t 7|V9wu_|(JKKK\\\rrrddĉ{QQQA;vӧY-Jݻ{뭷7٬|MMMLL˗׮]vZÑW]]MҦPJ!!!_o(J^^^\\?ӧ[Nz׮]=\kk~_(v=!!gGG+`ٖ-[vm 4O>999<Dy744n6`(Jcccii޽{)[u|{{]veqr-111w}'CBBEiiiihhhjjbkf.**ڻw﫯;vL*g|wܱm۶*=y [WWʬ]v\8*&zPUUuĉ/_7Z[[Lr?-]Tn1bccg̘q]wSS__?`od )3mOcEǓVŋ dɒ#F7꠽o`&ާ8tЁzURRuwFDD\dI$ 믿_jkk1bĂ ܿk#ClN}}>}޽cs!VI~駙[n6(^ﶃtȑ/d2r-Gݴi}th@>̌)SDFFҭ8WJ A@MgΜ4h̙35@ K/$$$ 4o2\(, v endstream endobj 424 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 391>> stream 8c`0b p@(mftt,[BH d>(k> Ys) 'S0lQJgbhCTƹ6w!~$,`sI H_s3z**E*P-@ 6m NPLTUHy@bR$-cٯqHq"f]0VA\=t@ǎaC!l)++;ה>(!m9%$SŒ)`@(4,@sIcB׀T@I?KO?&s3lxvbaBZ609ZK0```/SX) D?GV$1!_Ҕ"\ =" endstream endobj 425 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /SMask 424 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om_x \ endstream endobj 426 0 obj << /Type /Annot /Subtype /Link /A 427 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 154.6650 147.7500 267.1650 ] >> endobj 427 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coveragehospitalizations14.png) >> endobj 428 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 429 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 428 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16043>> stream x}yXG沨 "(\T5!dL4ƌ$3j2$O2YUd2jb45.#o]r-}>[N:v_to͛m6f?+RRRy_|q$Id#J< UcuN:w>|999'(uJ%R*g(̽{X7HII ܲeKBB–-[6~*TqrqqIJJ!88eFEg삏@$tTfUC=C3gjUlDQu PZZl2"Btta@.$;MMcy1** -[c8Y}J8(y >ɹ|2y>YN)㄄J;l; B"Z,QϜ9C$I|Ǹ:DIlAj&_| <`,OnPN 1c \H5?BQI|CQLX(,1APH4)))!!!/2 %}Fmj9 Sއ1{lUŋZշo_JYdai0? 2oP$i9eRg/QY{߻~ h̟?2:.'YhƺU H\}б8r’)Xݠ#Q'R%@27:E^( Š %d2u-88iܸqk֬),,~ j&˿vmd͛ͭOA'O޽{_%G(A4uuu1^reFF(/҉'MOABZMT™=ʕ+wp@7oޤI:X]jʔ)oߞ;wn~f̘1bĈŋ)`+J$MuuٳkkkƜ9s̙jĈVx)Ȇ+9(xxС / PmouT %}裏{Ǐ)LG`8)cP VUUoCBjIy,nn$ +8+\$M^HLr1cip$IbkkkXXXϞ=H(HP` *ĺ EQ}5ʬ8KoP h.\ؿŎE)CkpHa*uK~JSRgDѣG[[[ii) &M+mR\p`CVspU+~$"⚈JB֤C...6 mݺqӦM&yX$LF ;Յ %sZ~\JTiؾlذ!33bccʸhJZH@)))...|wΎ---X,/^>;{P,gϚLतh*x1:rT0Ņ&L@[lpBzz1c222.^x[eQA*LQ$I[lٽ{^JNNZsNg:ʈNH?7@me$ \wY 7nOznjc4ϝ;g4M&Ӵi6*^Ͽv hii  L#Ftcǎ[VS{-XoFĩK*P5%I 4hPzz޽{׭[Ч2cgE?@pǕ~b?ǡ4W^:u믿(E=ZlZH"ɳK,_~*5uQUlEhh( BmwE%aaa$ݻwKbް/pppZu \"]#< [{PvJ~,ώAؽ{X|vp[zo0/B]Uhp[ JnPEy:JvPիW^Z?i8o8 gWSUyRT N})8=r%kzSr2 q:qGT٫$5(sWj'MS/lJdw2,2/)T;\e$5ǠJx%"6 WjBq=`uHL:"ػܱf^rGu(ID ſOz)?hF*ݻpȑBJd~~ee/.7ǡg!.ݺuN߿.^H}j$M̙;ɒʂsQrzz S >}zLLL]]K~ᇘaP0s&ٺ1-vDDV=գGGGm4322,Y|ƍQ(ɘ1bЫW˗/3fݺu!00aaaTߨ<@'%'''44W^inn ;p@CCzg5,C Gڵko.,,߿ÇF#zۊTԸ:N~!ف[nafϞ]^^D:);0JSOVf]5//Ν;C  ݻ3p$I;U E ill\dIYYٌ3ط?JS%JPt0!%IZ?KT &G^bGdv}$L&BQm9ł8q"<, V̕3g|׍7nR SO=`Xl'RVR/PDoF\… x TmܹV֭[T"KƑ%Rߧ=j8+Bdd`y6)8?C{'O$ĉ\(`W#]$It555*_"< |ldPP"&NNI( 6B1؃Almm6l9V䉾ȹQcjeݠtȴdCH"Cq1\Q](1???++ :^Gz-d`@S(.* =A@%666._|ĉl a_ ;wKe˹˭P:+6`8zWpŢs(REAUrfw)@9XE{Dwww6FcnnnlllMM UAo~KTHQd=VP˗wmZwލ\4.&AH>~kk+BqY}WoEBV^ļg{DӻwjVزejܵkj;w.bgh!ˠy 111&i?~PPbgj 06icv>@ AAA\(gΜɩ^`ABBB``z3cp$x-P#I,)Sdgg[,e˖8p@EbgjU"?%;@FEEt:773f8;;O,B)wH͍8;;Ϛ5kF$jk.qP 4nnn/a؋ǏO~')hD, K(}7հ0Il"vv&dJP{t#ٷ(9`Je%fee_b٤MS VY;E}z=PZt8ĝݽdʔ)4O;~ZZ}sssPP"tJUddt_6|M$??5 裏waSʦEM1V{V:t( %0ɈҪN8hs;<'vzC(; Y1 sjll|cͧssw J$V]r?f[Stq*A~O=e(1z§$ Twd]cbp_ ư>}g]JpLc6Z-~-wxpX+SPcC&+v,Q%ȅF&N"vN%{3!- mgň%%(7"" ](((_Vl޿? :U3o&`"6i۷o;vL7o޻wgvVӐm&Sy?TUU X]]m6B.EtJĜӧOFtuӧOر#)) n߾}Y )X8!Q"WAbbb+ccc 99իTP1^|8r#Gg<'2Ji]ǧ5:::+++"" `0.U]MRUWsB qrr***Zf 2kvSΟ?jzxx0 '"[}o Vٳ ?M'|tfΜ lPα*f$ gt @;6n68MXP_,+MTTݻbaO*C#R. d0(*(`j>$` L?`qҖCQ|(9+VLP>}fѣG477`# 9Бp2.ِkuRy&;dpE=ypN"A93M8*XUU>DNR$!Kxd17&B21O!@2e>ȖyBK-s[ c1yyy ߴRոJF9˼u6jKZA^ J!uf\ '|;~6!UVG])P#GfbX7g9TDF;0"ߙb;0+P<{{~9]͔4ӦM=z… %I*//Ș3g˗u:ݜ9sH8Ul[G}$O@9p|HAZԩSO<~^=*(HL4ܼyS$''~RXƟUl0b;&''… >(m۶Z޽{;v,<<}jO 5āD+ij(R+PȯǛ7o5jT~~^x}jL* Wzwڴ'!Eܾ}{~~;u떘ᑛ  L'_]"Ky+FՖ^bg(**BzQQQXVV>\şړpgfb5Μyn< R+e~~mdaoFt*Gvvv޾}{RRŋcccW]PRjj`8"xyqrhN\\kPPb纺;]x3nMMMMMMz?_'+WZKIs}} +-- 쳛6mZ>|pxxHgQTYPN{Fpɂ 777:f HQz)'2O43#)Cnn{PPPkk(ޓ'OFpsjH aer foo>}L4)44Y)k@]6>>MsoKoÎI,\M%%eIykO Yt_#/:RW㞊---%%%III蜝/H D J%lt T'0-,1[8,;KXST;RQҸ 2 wHtL?n,R$Y(/+BA(RE-J((;ƾSQ½*I+\@u nwT?{رcWQwBczơ3Z- 40uT58˙k%(iiiIssqw @A[U f֬YZLJ`ALܿCdHC3x)'s-BW,{~}.B l4ӧN#uTa}Qk+h%pZp%jPV[!!!T][M hUX47o B,..NMM}'Ϝ93{;]] ´$IǓDs8y$*aLmpݻwy#G#((Ƞo 6[&4oZ9%H 0Q "ISO?4޽{/fmIhfJE3y z H}44\9hEpzxyϚ=MH(LF#fkjjBJ[nt?x𠓓kYYEg"FQp @T8C!vrv޽~< %/lLeM^`HWw䌌%K>|nKa\ot7]n㠒h6eF f<5 @~~~:eҤIfn7f(mw/9t)O$B`W޽{k4A:Ȑ@{@N^(I Jtor R̖K)E(4b\H66+@`0š;+B3)"1{H(.f+%Pa>A Pdg,+DU_%ͅɠS B *j:jw>u'x10?d (N}/qəÇTINN/<8$h/IE:N1Q':CW/zkOv MоEv@HJ k( z1d8ӂ8&ۋ*$3YE J+1UY!i @ s4 SÉO<5/1HS`hlm-h Խ{:EJСCM֫W/t*77w \re3dr9sJAȢ"t#^QXb^M#z F8_zxxpr%$$L6=##|:7^21[7zI5,j9hO>ο벲2//}„ : Ir}*i)eoشiSEEEllg}=j(>> ܘPqʆnR![Ź}}^[o[||ؕS $wM\=.ٳSNmllDlZɩb;HHew\'=8b6~^I [ FeXhTN,,KeeeTTTRRҠA lc%fLJd u ll|PdX}t`v@O^=zSFF~Wr~@&791ad)H.eP[y%zPH|;v$==EE@L&6f4Fc'j#f혲w `HHQN5!CFm`OWc|20PrQov,&H0@д˫ CdJBGk,#|)Q"9jL}&%$&DG;EvPxܹy汝aH*tRHuӱusΗR+VhS\ 'ce$ h(ѣ'N8f̘9sP___QQ1bĈÇcs'G .FUUU!!!Ymm-tdkJK٫d@3VhJJJDQtwwai?,7Ta% ';r)Sh4oׯ__]]}_=??`AǛ‰<nj{)//?~ /PRPWu!m$gKjY /`ƍ999LS < `8@%@#@/. 77Vĸ`0TWW744999$\G[h贲R{UWW 0!2&$P ܫ'|ʍEFw$xJKKuܼ}?y$fNQ!岬ĩD,Ic%I&33s̘1 byft7l6Ϛ5'HJK1Whld~U*H]Bd4 _駟Vs``J51 ;BR"]*%߿_vqWWf$pNJ{g}jF B-@wIt\% 33sӦMׯAѠ Zu/j?YO*]K]z~PKQQ_/٠ TOTnxvaҙWv $%n&^%SJqƍ7mfq5q4#(t EWPغ]n'mNbc`0ۢJ+nfW= .m5 @(ukEd \o,:3fDB n]/Q \Ԏ /t(z2P_{b}"79!;D` 8 .QVgKiFn.$euCy筭:o߾ޏ!5 qU"rftN%%򠱱h4VVVٓ?$^)d ֖p1 " ?y0>---wqq)--%MDCw[O $n F{9Tz$ ~SΟ?CsN/lW\y61L:O?o6l`6z뭼݄Z#@suuu,BM E)))djf:3)4+@whѵp#GzzzYfƌO?kq~0JZ[e+W^ޕWgVg:tK;+gPCOIrssEQAߍ#yAϲWt tTvvvCCCnkMguQ/|pJ(Zׯ_ZVu+V@/~:gॗh.pϼ"NTXXH>Y_WWG=o66zNpG555FQ"\ziXt:$4YKMM` Kl6dJ*++- Y=77`0t{*FI?>jI$f,4LUUUzʆCə3g/_~94Hm=\II rʗ^z4Ǐ?'CjժM6[n ʎf裏%t)==}͚5o6| &>\l~{׮]VJLL?>}:**ҥK$Tiii&?e˖!OŲv#M[ :uJիW㏵<11ʕ+nnnw RRR PXX~6̌8qbxxP "Ν7o޹s׿zdZї%oݺo>|}}+55ܹsfݺu ݊pBppl裏ԅ 233ƍw&09rJZ~8sŋwڵvZPr@nnl駟VXʓuVQQqmAz}aaWyyyQQ~>x'^~eX֝;wgѬO>_8}TB/Ktttzzz}}?7}sΝ;^{wf̘1d___OO'xرcfY>7..hĉÇojj ٳgEEŤIsss_x斒@C4iR^^===޽ꫯN2Ew}wY|o߾}ѧiYYY%%%VuȐ!۷o/..~ǽV#BCC}||"""v=|#88ȑ#5}#G544۷o͚5ӧOOIIYjUMMSO=ګW{o߾iii:ҥK>>>HOOׯ_XX.Xf577ō;6::ZZ '/gL|UTj*RfZȑ#3<&%%]xƍ2d^$ȑ#)))[nE/$)>>ԩSƍߥ?vuu9rdQQ*<~8zYfn۶mը$!!!%%eѢEݺu۱c$Immm)))!!!lUUU]Xcƌqi%h>>>/~ǎֆԖ.]KkoذaÆ 6-???>>+ZVE&LpI )StnP2ŭ[`0߿Ϟ= IjMLLf3`X-[p~0//_t7m2z=fV$555>|QڹsL85cΛ7/<<:_|ϯ@6^BΊb-))9|~ŋ\e?ř3gN8ѫWЧz*88'sHEٳg6gΜA<`ٔnr{N466:t}?pFV(B18v_JX]]U[[snݺ=Ҩw:?~ǎ(Λ7… [nEqy(3> endobj 431 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coveragedeaths17.png) >> endobj 432 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 433 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 432 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16853>> stream xy|U?}# [@XduA"U_u+*V[,VAv@IH ;ٓw{ܙ9'l9ϼ=<̜9́bzjt:͛dɒ3g 111qqqׯ-ܢi|q)AM84z΀JJJyޫWDBȬY ODbBGOG`lw)7=R2юsss=ʟR{%ϧ ݻ+** *(d1(n7L盗R*w )E :\^הPTB(J@]vҥiӦ)L9 O1PdbA e9s̡CltN ]QUU%z7V/ 9EZ oxi\WBCBB?5 RP z"C˧Ό|Fu+/~ܹsPrA]lr2ȝ^k?٤$u %pJ25/ 3OR=;-|;A r ԣ CǕϫ ҥKgϞt=L8@bb0GYI^d"ԩS`̜9sȑq\4\UU5{욚1gΜ9sFp8x :qYyGנBs>CxС<]%>f Pg={3={pd(O/KYn%m^L۷o:t(! Bo3H`ʠ L:F )r񼦠gzD-MSJ$%As7P+!t:Y׭[ظj*Hv%"2cܐb>añ}Q`) ,/^aÆRzӋ€}]ʔu???{ΝٰaCIIn/((,E ޭt7AM&*Qf5kڵh޽.]PPpǐ4{uW /C{=!ᄏzM [Vǔ-ė+@)'zP;;s:ӦMׯ_ccti)olz쌚q'NۙNbb0[]XSOM=(Jȑ#CCC̙S[[{]wS\&R{Ue_ܣGŲl2pBĉv;}:50ͣs"eyX7yM@Ub:#+C !1MyJ`^K(*MVȑ#$É[_ 4{P¨ JES$JGw~xz enhhիWCCp  /DF@AY*Z;~TOXd -C9)]lX L*++۷c=2pu{ X@ ('BysQ,/=Z'\P戈ѣG7{{ĉEUWW?F婮KSJJJ~Bc>Plz^G:?tvv&$$Ϛ5KzP$GER2]zJvCeee;6;;ui/ c2^Nآsڵ7onjj>~YYYyTT]{vxx&_J e>~i~߱lկXɓ'?#]{|4O9IQڋNP ,eĈ˗/jMDdPeSab0LSo6yC^oc\H)((mÆ BI&z% mH_e-A{$! .$+cPy˗/ˠ#5VW*{S(UP2w#v*;; 6L[FR /FJ"^V_ @p @VF2z?cOCA>;1>,߿?O[;Sn ĻOPf\wC7hz ɉw07CUK)d)~[R/כ!ƒROt e3\@y⪄m`+-BDk+ +A鹺n4>Z%5eBol֭R~q!k ]p!-- Ν;^GF^7zO?gGpoJ"BzW/R׭[gXu[nky"#lڴI3fYW^G?f͚-l23iȤI߾صkWpp~3####;;{…Nr P @=z8zرc}[1B絁@<׊s痛_yĈ_}UCC۳Gh !%Xc%gX,N8?^z;v舋$JJ7yW ={d2?tΞ=LwRa̧o?MYvs΅2W^񑑑3g qx2ʎnМJ(%B^^ŋ.\XZZ:sLy'YSG;/GR H>k9܊<{2|uuuR0/@ %% w%''Kx %(\軡^1"4@gLxGe#to22 LD9r #^;x=(0Qvo^CT|Y8 Ak r)B?0"KJ(ş$)c(heezWF?A4#+]^ViH /HY+J< J9|((ui eZh}j' M`Zvs mq=yAJS3šjcYyCq(ѣGv:33wߵZiiioVSSz@Zn3"߿>hll|vڥ*03 ^z)33^:y򤌩gY :P^ztMY|999/_NOOg@>|x֭|D5ҜBsa5U)Ś5kJJJ6nn޽{߾}xlB j׮]yqqMQjj*$TxJcd:t({Up$&&FFF;Bj4kC&!366O>Ce;+ߕ65\aaaYYY ,`788x֬YÇd}+Rr gIMMvgm,eO;3gJNdz%%6v@^B,KuuuZZAფ қ*GJDYWBDratNu +LÆ (X Tjt4@*RVC 6JC0Rb*ϡA/6gL.]b[p_êg$Y]PJe^fYV1=|u g=v/i %; ŋT(3>}zwlӽ𴣞j%B.?λrbk=6+V[r~llo J8%!Ŝ|a"WZ)d0i? X""#vt?׌D!{D%# 1p?q`hOYf/^XdIqqÇ.8:nCr;BܐRzرW.Z?g . /ɭgs 0ŏ\2{=$%%}GPHM0ƬPȪ*`+k:M69s̳=䚼7Ȥiy5ktvv>|˖-͋L8/gn, $y{ǚ^ٿnnnUUw(~ VOvB7&J X/0uԘ#L&n'\D@AKь( O˥LTE)5KK̠J(smmҥK}+VHB -"CIΤJEy>i({D/݅\RMYE/WKӟzV.,Ϻ@)QUAm6[mmlwFGhjnPz@Ųdƌ3f(nW"#fJ*nZin+"@)#^.p6Z~;X]A 55Č?>""rӧxJ)R3LqcTU=pȝ+xÏ?X^^~w>}=]"c4QBYlvwNf (yϟ?wiiiGPq xyb/L}GG;nݺ|Izz:R਋"M>!d͚5l 6?@ii pۉ eJOG_9rUVUTTs zQ"-k2ԩSlcg4h ޽{TWW#% ~H:߿W\>|8{7&&!+o8A!]݉й !ѭ))).]?~ 4btizSXXb fЧ~.Λ7pܥtȳt 0]L[n˱T(y6lؿonCO@Ð}KJI4y䎎\*ç1 K98k.F>^7 QVOp`,B$S'X [ LcƌILLlnn6+D1FрKH*&G$2!R1NtSy(]AqFPj̕]”m`kãJى?NYɑj_[-ylabڞ\:.}̘1s,;;{Μ9GX,s;)]G9kH9Ay !999ӦMۻwo@@@l2߻S`O>m6322fϞ-(AeaQC2:t(66xSSSϝ;Q]]m작jJn y&@ W~w}^;D%0{sI tl6[`` {G8ZY (G?*hĕP]2;wvv666={\uݵ'|A|/C+< ū޽k/ \LC<9!cW^]z1xJC"\+Ν5k֋/ M<裞l*,L,d4J裏[tݵ|-\~yfv๱8#U dTw,ԠLŋA`z(6r㪡;S#"D3=ƞ th~饗^z%U}AHQC 5>T'61?zKvOJBVf HNꎢgUڊ<3*tb~<7~W! IWPMTPfaƛ@\* UV(#W,:|<0=|0ك4}MY\܀@hP 1YsO g$r]WȤ(vV"NgX@PGR ^T6J؎XUN0.??{g<;DWnOȒQF>}Z^i)ݸD 2>|&/BEEoFfx9 ~+Xy@d%\r۵kWvvSO=UZZОx9ooGzzzqq7yNIIɪU6o\YYkUV^)6gdTxslslxav-Z$@Y1c_>==ڰaC߾}ӯ_ uәoG[ԥ[ZCBxJ~JJfOVksssUUjmjjϴy60Q,B._\RRez7J/?~rƌ.\7n'xBX Vo2dt:}||ab;(R9f2onM6XԻYS,ZfԈjM\#b0wUP”X>_2z|jsIS6pJ&#heY ↡X!2%(P#GtҚ5kZZZ =5^_΢Lo?>;;#G֯_oۻ"TXNMi % ;J+WE tY;_ӧw}WXXȾ +0{)ïR2dSO=URR2f̘;v P( g\C"n42zP)x^eFVT5l(FU#n$@L^+'1oO>ݵdt%4_Q_g"xFj]f\c(\lS!'BΝՄΕxP6TB/Az4gXzPPRAQ'MMMl!{ĉE>}z…Y$ƣ:ud[l1bDhh\1 =L `Ve x瞘wyy2Y ̡{a(k׮5jԶm۾)S?~<,,=(,!)y}N*񖗵k׶ :tժU3go~뭷E 6DAAh6'؇>%Odd$SL!577:tL_D Hm"+ a$///$$$>>d2DEEM2+P'+P X\@FIqÇϛ79**gϞ7|sRRR<1HaaڵkO~hl)x-4xվ$wnÑ'j*Z+Y6{ٳ'99(K)C)uL---`,&8U7xp!RY.OW;1QRJMaV [GK$Urf=) 8((H3%:|.VP %+J8+G/vPG, r5TTTTQQa2^I(6MϠ<=T%zվ.Ѳ8N$ZJ:\SS\,- {OJfpM7ݤ=Bkvv%& 4y^_;^ҭ}{.޺|({5'Խ _x Hr…o}Ν.r:P_/|45c]gAP ؀.O?t޼y}Yםr2fh2Y%2L&ivn:ҿ[WTTX;jg5yxf͚^zm޼0|{ОL|:Sz>.y^A]{B?p;vt}70}*\`(D9lǖo)44*v,LMTzAdddllf4h{&44̓Xy=LY#.qk~wنcƌ (((`4Jpt24(sQQQYYYKK˂ @Њ=G4_v[߈zrhʴi#l/_>| _PTm'Nl_=MJ+U퇿ɡޞ6vcQziv{bhc\|BG)<+s9((6StttE)moookkKd. @)qZOA8` tز%n TQY[{ /6QBɽKۏ4#$4mڴ{W1ъ'o lm.Xa0tOV0n"N a⸄&8)(CJ/#ڠW(uGq5&YgƗ?-0(kצ>5>TB&G6][@rhXZ-I;:vAg%?v(A`E[};{[Fhv4amsb'`N&N43YkvJƁ^СCOޣGv2//oƌcǎM8*ٿ?96'9J#qwԷyCUbG޵XB=2pוZ3ZC2-} dfEUSğP+%-]Tw=}~ko{;;C)#tz-{'!M$\&1(SAA p֭[ׯ_bB BtthDEO=2Ky-ywzVzתz뭣GX"A-<|5`?,LՀ]*'AH(a[lYrj}g\*b?BFE (]eޥXځvlMȰNgkkkmmmCCOuun]G]mi&7#DH ]XaB8ەx{{ٳgv{򥇘(X>J4I/e6mAk ՃU0ͱ2_)Np9q:斖&[o{1 pX[:)-'d VxqS;sҥهI#`%$(&G ɳRuXtXK@d={C6Ռ.~L yJc?e)w4F^NBX5>jhP?J&RNW(-rÕ, {R[SU| #"gvyDG[^zjU EguF0?0V}&dЁOK]Ə>y ]w ). {!),@Aض--* G" m4&`$!%8]43VU2%7+'` @@@@kk+pc"~D(A|)eWc{T/mKAz ^|Y L̔nV"}?7!53Q%1*@{PZNa 0uq+)) lnn^~kw@i Hi4;_(XQ뺝.VF͇q/;׿5sիWv뭷6C0* fvi4Ji!c*t:veЋ]:~/~QQQ"#voBxVl: Li(!UXmV%ź[ H4T_~%!tٳ$_FB 8K nQ'Y+W\xqժUfshh_PPPxx߼0õ} z(mb&J/=p5KIBCC{m%l40VRD%J{*fR b&4pFeȠ=zW39YPZͱb7@_/lpTͱ{骼+kJ!vpR!vJAC Bnbb| X ỳulᆭ'berڃOrPicg8=X¬QrTW<$%6 6 Pz6JہO79^׿&H`.VPړ@JnݟBBgv(A@'h3%6] j`"KH)5`!=@JX<okl f*ܵZ%Ai6!czX8D AU,uI-e|țDXցh)rSDV4У(~1ًPJ}lמQPCp g08Z\ı: ii||lL67_ol?WUl=H4c5W]jeN}N{طo_Qjkiٝ۷oj@:@:IД+V̜9xǏ I)ΐB+ V7DjzUWv؁Օ֖ٔ~˗[bU,6 Ѽ.7<9}@?p8'Ot8cK,. =f5oA]1ijj*,,X,VիxN)6O6\l9b[quuuGG央b655ivbh Sөi 䔊 gkooX,/_nkkӲtttXVs`mm-äf񉝝T(Oބ]ф|A߿xvej/b^sҥ?x}}=o?_*''gٲeVmn:r; 6꫌;bŊ{Wpĉn*@=_|_wnٲҲN[~'4+g~'O>rURR2}t7|GaSO=pA+0Ӑ---3L˗/cǎdgg9sfȐ! W^}\xq۶m&MJNNꫯXފ 6\xq%%%ƁWjjjhaɳgرc{|+33졠gϲC%$$lW_튖x񢏏ϸqN>ϟ?{;w.]m`=ЦMz)p4J<駟.Y$33gdd㏄WFDDj/{O<^p86nسg˗?䓬ə5k믿+"}FN9)))55n5kVmm0a e;85uԄǏe˖Nsٲe;w|A7==[n7nܐ!C(;w===n뮻Qʕ+|+WPJښZZZe555;vxWZZZ>Ç+?{ 7o4i-2k,SO=p䧞z455A9JOan>۴iSuu|7{nhhux㍩S QYAuuѣGǍx{D@hoo}zӧOn RYy6--m?p]PP. endstream endobj 434 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 435 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 434 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 15819>> stream x}yXaPdQ **உ{\h&In5Y,,hbEju 0j4.(Qe}daQLQ]U ~<<<էzԩSzzz@ӽ;vX,ek֬ILL|222}كJ$I|*Qf^ @X;F)]%ӦM[xqJJȑ#ׯ_;:uR6P¬;F*B(^fksΘ;w&$$8J]4HFi„)xJJP@cǎ+W<3!xwSRR{1WW=zL>: I9$Lע|VWWKꫯ-Z4ydF˥3::?piie˚^}U???XbO(%,T$IK/kL8qĉrhhlr cS'Z*h:o<|:fʢHLj>ۋuZM K믿OB'Odt> i>t*ap-dh4Νc*7]1 ]r7$:]ZMnVShu }B'LO*4enP߽{wڴi 3^hrvL塘BPYȀ@:JbL*`Ρh222/]2lо%Z$`NEEE#Q@ف13Hm%(ڼ@IuvvѣG7?Vlu}q0H1yatiB:DvZq fs:@F(|=zt~~~QQДA mb$<4q@)U`Lɘ[X!,h(VB(׿~͛o߾VVV՘|Ad/: ~MO>駟}7t%\ZK$>g@D|k׮Im۶ׯ2`e)mnn;vݻwŋz˗7sUq[žʈ'N$$$@LLӧڢ(uh 紒hV{uuÇccc322 ::lfx2(qۛL&lӵkצi4{ԩS^eZ HO 胵ksҥ@mN(Vn a5u۷o/\p3g5jTUU+਒+J$mEEży󪪪ϟjԨQfDm +(xŊx!'=az%QOh+A1ү_?LqBn3hˏ92|p.)&JX`LhzDlgECdJyr2(:%I%((EH[WATF9eWP!U(ڈ )Wf% 䀌-P!ҥK}||zq(_DSUdەiXKYSCi^x .3T/ jSd #astܐ.'|a-iFZJ W^z郍Rt4Okk| j6+~$*̪=ug:T4=zX,(99y׮]z~&}@xL ?E|rddl>r۷*4&c/46B}ٲeKzz:DFF޻wO/F4+a &55511 ;vsNFFFdddqqd|CKTg$Tt(3GqCǏ/,,<}ݻw &&̙3y%=qVm i I!SN߿?77%%%}U.b=fJ"Bs綴>,X?׫lUiGL W>20w܉'VUU=CXgѢEs`*?ׅ"pPpԨQ{?~uuEz=Xbʔ)ĸGQ;0(Innn:nݺuXuʕĉM&]AMy&ζ/"> A1%.ML4 =Θ[Χc:"mP3fLNN//$KB JÍbPLWa"\애p>4iĉ[ >}:+) !B&XA+dZacZ|MΪ|udw1clL48C_NRLdfz("~?(zͰb+1(cgX߿SO1y 0ݽo߾ngIDId%:PXp IoHHHffhphlmm>}y$CFM/0*3 FJKKO8l6OཕLRR !ϳ hkJ4x`??ԟ7tS92+ܠTUvڴi^}UL=_z5^=]BĮҢ 0Ls. $);;KEP|zR(]E 'Ӈzo`Hv6CgϞz>221231Җ>?34t,CvܔO 1;sv(ׯ_TA\4acK CLn?U>XB>ヒ!UAf͢[7&'WM5?ޫW/[FcBBBZZʕ+nܸ1lذ% wСYNZm4Ho>Pdk!xyytfOO!CDDD8;;< 5k 0*)ӧVtSLݴi#_׮EPԺs޿n˗/ѣ-kȼ 4m ϪkGt[fWP hSbK n!* ̱:N%Jjْ:Ct (2oCi_\\A|#Yh8˜f&MX-))?'On޼`00JTh g%(᨟8qX7xܹs >.ctQ>ʕ+!!!o`>tPiiiPP7& t<I$.aB=z o@z`4cA _Qy|GFGa+JP]RhEEEׯ_饗njSXX?G;B.,))5jn2GݻJEEݸq c}Ihlnnn(AE5553& `…EEEK,Q( FP%'''44THT" Q ёݝ^{ M<)K/}ގxG.V#G"WDy5 .<>~1CȫԡH4{l|&I~vn pImmȑ"/޺ػwoE[Hf+E^z<*T&qeH B>PaDH!M/%///'PGeP>...4V<90LD<DiU m0R_SWPpAUASїpB0(zrO ,Y )Hec;w/Ϗ?NfV{~3YU{%%%Լ{O|#׉t Jӿct:<;vΎۿee%(@=g!?\x(F?"""66x߾}C)6Iouҟhy鎊"\Vm~xWLjXWD%fEc(!\B˗/Wh4`}%*,l KHHxG ի]]]`ŊJ] h_{5 K.]lpB|-&F%t.*K}fcY#?ɷtX(EkߟWbJ{]fk :IO}[$(muJS__3L4W!#z C g TFZ\Š݀Yֻ 5L:چ"ފ*Udm\%gv UTGJ쌿Ҿ[јɼD/wO{+WDEE樨(/ 1)2@Q%!>,;;!_} +Qejޫӧ? ;w4Ǐ߿l^p˗֐'ڥEH2($Oz ""uȑŋ0obeIijj:ri?ꩣӧgX]VSʦEڶ6r>} 9V0|N~--P[q( E (D\(j м{$IVWW]ڰa͏@ʙ2￟D?]YWw~Yf1 39;PJrרB1i" wKipIHڪɫmC:[餕v0apIsyL@$ 0qWki#(: JNN?wT&B$,Yמ7ox ؼ^蒌vg]{ӵuuX;9(`]=-b!Ο'תWMP`&Q灮 t%Ħtƅ`iIڤ$b"<`1әEԫp.p=ƹΫQn*SRPj}VҔ 9d䐲D:ȊЄ1q.4ɡ<+tG EN_R2#j lh_yVqXL}9k /OJ%ӜY]@*566;vLj%:GQ6 V9fuNTڏwg8ȑ#z36Ku(C1$Iڳgϫ䄟ɂtH@b©$Q$Jol^zߺu ?g3gn'@5@ @ @5@alEEEy f~3H{I fU/C%h4:4??ǎ!0 'k 9hh2JP!;w̙i&l>SO@Pgf8Y_ƌYYY--- ?Ca=f (T݉QQQ9kș҆90G.)0tr}gju:]zz͛7mdK" r;3a!O-N{#'zs? AZj2HF[}{=%1%BG_ԘB.=Wxb;6A)) %d{q&JC$L_R-B]\Dm"+PFGߩ}uH9u8r0EѓR-W. hPJ.K(VD&UqE>nӍjXuec MY|HQ8"8x*@Q(:0y&BƋV%Lj+OshȞ!Ty&ypg*F,C1rҥf˗O_V2rJ o/"//ﭷ:~xZZƍms]ݝ%wzT2qqq]z~Z\\}͛7bgRի\ \;tpˆN%88~Ϟ=qqq+V4h+*i`0;Jvvw[7TӅ;Ӂ ***7oLק֮QI@Kmm-B(;;7pT>OC*׮]+//1cFJJJYYٸq WɻA饗^6BbX[ ,Bo#b!4 WL&$IB-0 ڹ#C,ӴUaZjHju(V"kU( G*IPǒ\"g>/4+<@tJX`;a:\TTwލy -Jj>_EXrLNNNKK={LN0iSC1./;wmvR]Pvӎv;quuxbHHȦMxԩہt.0 {{7=zjذaL ?"Td|\UUe6SSS/1oii Cl_*...**~y8lذ={_0BQ\\̔3U&]Nw!TTT`֠ Bjmmų1:XZ#_dMZ7n|^%1L|yY_׮uXY~Z̶{rafaÎ=:|%]NF +Jٯ_? PHHHffh mii #hb0 I5jN9s&bƌ|uMQ~,˃>XSS3sL>  8F tJ >׮]k6n3tdC”PL{wpӦMCeeeɋY-2FŤ^ xzÆ ۷o:w\8y򤃃V+<?#+0>Bchng,^/j .j4҈_k.Ns!;;;<#TyZB _lEjGDD?**駟D`iU9Єn\(qڵ+W=zn`ˡ!g!J|Z,&qs# `yP544tȐ!ᱹy nn}$y܄0>d2fzh}$J}jkkфZ ¤2&̀..='ba2_H蘛 . C9"$UŒ~(j%%%˗/zh,^d2ξPPPP>>>rwzz3D?~n߾@VV;,)Up9)+OpIgpvWKlYJ"P:+k׼׬Y.X8 a[\ "l-PqI%JXqBDyTYYiXÏvĜUK]|%AD#*E;eʔÇYp.n&! ̂F{` _͚(VZf)XB2#vPbZBS1mmmrk(JO Q^RTr`~Zpt|8*+0G@P^JT?tAFXVf6@h_*C!4Ç>}[>jiBR!adP޼y ߿o܁Ҿ:$Ђ$ P^-"n111x'uWbJ^` BisssϞ=Isww?&Nʡ 2xya+?`OoH2dP^hK){+KKK###?9s3NWQ[TX j IPs۷o׮]{7x ۺ:vKqy$6^ӀFo'Biϟ??mڴzl>R]]]WWgggWYYi2>FYOR~?Ivy믓jk·Ξ=@y [n7//o̘1&h}bʝ2 DRX_Ӆ&,<<<..///ٹ 9BV@2k{j"$@cmss3& >>k6=<<3  PA2ֶ]`_{M(xTN@'_Y^p!dee1x0 G{xd~n~$!p?nlh>lɓ'==٨ LI rgB͘U>X(y.]RlXc)/<^&s{ח^^~Lq具^ա~+W_Ue%]e>!* +IZr' Cmm1p@lgg @Ҷ)(YYk"_fj M7?e3 j /`(N& ^S /X.lF*!foPvyY,%HN*dTf D1ЁA<>_S iSKJ^^^(?@:µZ/餉O{}eR@.mN851_Ɯ"W[Ḵ+maaFpBLL̢EjLӌS@ *v4N@d2ĊWc(55.XXT7:6xquŭ t.<ɛS%nnn ,0`@rrN6lXZZZjjaɒ%) ::zرs̩6&LAp N_Ś:ukpyRRҺuhMŲnݺcǎO<wC7.00Acǎ%&&ڵo$566>|̙3ƍ?daaaG.(('O/eIIIw^~=.ILL\|޽{%INLL?~nXBBBnܸA[7ZEENJ+~czjժ,Z:44[lٲeb=|pUU~ ~,S8qիW%I;|7|3uTA*::70 駟UA$7ߴ &iK.:t_ srrzUVnmmmhhìJƒGbJShLō;vѢEd?m۶_~+//O$^L΋d***:z|W_]|Yl0ӧO3QQQ&M5k֜9sۍ7\244tƍ4?Qȑ#yo ?0`@]]e˖S2(/ arPYYyʕq=3:`0÷m+W )fkkk]]]TTԴiӖ/_~a%{ q}||> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 437 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 436 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16196>> stream xݽytE>JBHI v" .3;ΨqmdPBAB$d!FvrQ΅Y~tWSo[}aX};ñhѢ+V$'' QQQ[EQEq0* 2TL1cƢERSSjժ_|1%+P;VXf͚䰰7oܸ1))IǁB"Gbbĉ'L@8p`TTѣM&}q&(&zp(F2_~aaa]wu]7gULegc/qb1SeX\\l2I;waàM,jX[(TVV.[/ sGGǗ_~i< 8Yzu T(Ey6P 1KPff2:b WF5;zD{ѳ)6+ TFF9tP=p(쩋U%fdSS ju()ӟ 8=iR1wibqc(5'@ʔ]-;~….ݬzKhMV ^m\oxZK,wjLNN>zAdl,'XU1%rW^F_j.PR]-R]-}$4\WJ2o5j&WFʕWE;0|pE"O qA6]LF/**ӿub*?YCqi)N %%C҃2{{{GDDPӧO/O=T~~S/^\[[~pUU@;y \iiSSSy-[ 2$<<L(--՛X({$کZ"F@wqɓ{Yf@ Pf#E$N՛ 8(sdd+W}||rssmVUU5wܸy@W|f$֤mIs}ϙ <==oƟ~iĉ]m=~Wt%=uP1Bq\ S\]R(2̵62~衇M&?|ȤP +fqB&y衇jkk}||n0F9{v9.,u לTӧ;wn…={ȑ#xHCZVR(see󫫫Ă ,X@aȑvE ӾEQ^zMVi0L= O>=hӰ4k+6L}]tt4?\3NP%nB yҊ"ĂpP,T .FQy`zK L#FٳN>A #27}T :(. $|m 0O`IEJ0閽ZdׅqғBcPG}ՙl*Ú^A1ҫѫ 2P%)Dz|DW\l;cѣGKKKqq1W\X=+ɰEpEB5^KT`9I 0q~ _ɹűJILf]paӦM---֭i#єX J8(رc[l}ݹs8&R}\>ǐ-¥k^x-[JJ|܄`m]ʔAׯ_-[l\`?(Ԍ*-57NL$ʍQ 6㏅{ ""$5^tʔ)K{9 7Gm& b,uQ(JQP{ZT4z蜜oF8jC&A )Ժ@LstL$=ewΙc9R|.-zl1b̙3EҩNth)B+6jQ(ﵸ(i-k+c1)O)xqGP=7Urs~Ѡ(0vA vϩBWsP4"TWWZWW U ibgbr$*02nso@3j]?ъ V޻wZQk8'/pSP.gcѥs9e=zovYYYߟPUUu=t[_'}m 9ӧO/Yd׮],s@8Q_#""Ν+4KXL&$u"I 0??믧7n}^;v[[Ç۝K{^M[Ϗs<8sۆ#G:lΝv=22 Xj՚ob\x fϜ93--mǎAATPnZmJ|3f<3#OA?$w7C]s](*a|` 36_a^)WBGڠlf(rL_\\TSS#""2fIy1*KII߿7hmmU?W@9zP^駟Ey:srJ8kr{WDz:qرc{ְ={1B\Bp@6v],q8(BGVVVTTc=fZG{:g"C J,hXΝ0`޽{ZJL*ꫯ (**:{d0a?~iikbO?h999ϟ:thhhhxxx``ٳJYttJ}K̞=[Eֻ$1׃?h7<jJ$"^l U_mm-}%*Bqu%8p &&&44+ʸũ(蛡^>*T@[&!w el"Ci+PR]@8P@Hg 4Y]tԲ'ōT&ҡ?2]JH -s\q>n4YI@qPD{Y cK\$97` % LQ}Y^:,5yNGz]7"U|"i&l)c(!5R2ҡ#1ݦ1пضI;L-q)m3n'I@bPj>f12zSRR466&$$ "ipС?ժJ9s1fX_NII}O:%bGLE(Shhq, 333/]H7:v؞={*,RB5a6ծIņ nJ89;p۸ ԏ?XVVcǎm۶;Gv?-q16q5d2EGGWv{ddd``رc=<<>)w\2 !!!!;Kޥ>c%R={LKK뮻uѣܹsAR %Tmm5kv,Nx:6Sl\[(1;T WPb>?"eX,UUU q:u*w|_߽Yr@RODk:L=mxNP<9]DzYb]I~iРAWDRͨPe˖IMMM`@a(8&R+FgtIS77JjC*yhuy ޮD&T=5fdd-8tbN+;A! ).g̰00+¤e ңp EףO>ګW%le_|9H^bUfLVh$r 1QMJ${P̥n"SLLfX,WE@XV<ȻD }lӠL !DEW eOKզ~i[[[vv-[j[47V Y?Q{ZL4ĉv=66 WP__o 1Et!O>B43%k hJ e ظqn8qmv… sss']14bKSiuÆ Ç߹sE/e %+m3;"p$8=Vq|СŋLJD۹{4մՕ @iVeҤIt>}zfff[lݻM&SdddRK6)9)S,ٳL:ҥZ"2(~ 7 80**l ;S.&_{5*$JŤ=p.G4r}PX $(Lnp@!TnzPŋo߾ ӋY$u,us^[(ΌT(i>^wm/Lz@C(SGGGMM-p^lͻ%5sw723A:&P(OZ988x„ B^^ޙ3gnEQ%K zl 3sQ);EQΝ;WVVv뭷9s>]$cdRR(i] P7o^xq߾}FV=IO7P٩\-UzeYYYsMVkTTTrr,YRRRV7wY{s✤87lP__?f̘-[̛7o%%I`Rj|C7gΜYf|@2T`@dE _.\A̧O;Ӭgee7++*88 Ij m\ P__7|p*opp00Ndeei׻2d;ݻwssܹs322&LPZZ [1ͭ੧{TEv'tg߷o&7yvೱ?қoIe̙ ;; }hqww׫9x~L[yI ީNFXz$PK28dz[ǹ"OPV/&S8Bu|e_%ӕ-$D%=3fa.E|b'G'')(Q_/@1*3vX=N>P%c%QhF>6-,k;Qf*-}Z'6566&&&۷n ]BCmnQ!u:FwvVt66woYugI(c{c,@NfU1+=2GDD̜9s̘1v( ,8qbYݹk.$ hWt)@{UYSS3cƌzyyۗ$#Gi} uD3gΘ޽{'%%͟?_[ wګzG >*+sVVѣG͛G/|ա?SLLscGٮa#F;.TvDX_r?^ ٙUcf-K%KhlH⚼y/;!!8 `Uihh(k/DSj-d!7 t΅_=KJJ菫II ApݠUgSw9i$vR4 !EEE5Ȩ$j@Cl*+j6cܮ1?ˁ3SR[[۠Aׯ_777;7vSYYy<|^ mhxRy=ͨϟ;wK/D~I#]ZO]MMME'z7Zֆ\x+Q366h7vBўYm  1$ROMŋo񆔫Ye˹Z(a'1+qؓR/:kLټJ207WW|d"@T&v'H~E2\(V/J)]VqdV".e <.o nc v\ȱ'g&!0Hzivˮ q7AfEVzJ ̡(`+`EbchY/>a`丸}MMX5_ #lziպ!m RbSMuuuAAIjkksrr&L . ܽ{~eU1Y\\\__?jԨ3gП e {+*PDJM'NѣDZcƍ_Մ B>[YV] !~a^^??^$<;4[nʂM} U/э{uVTT÷1֤rR3Po-!![w1t1cƸo޼911{ݲeKwuY&q~ HK) `+y7]JkYZ̙[ccjllllhhꫯ$=bt+WB.]T\\ss=זNy…tǏ߼yf`1U1gҡC***ϟWH&uUP;ȑ#cǎ}饗w@n'QK~b{ZZСCW^]\\`Hp7L F6!$++kiiiy[[!M z ȧNڽ{w[[ۗ_~,m g.RL8wAI|PTTG鉹h쎚Pf??}VWWS75*..￟6mɓ'{I8$m8qrP\ڸqcSSSttufϞO$$$p l\=).ȑ#.\(..֭[gۇ wޘI&ձ*^4PntN6RZZjZGkkĉM&ӝw}"@B \ }}}ÛM&ĉMF+VKW lcǎ-ZjgԩQQQTKFĤVKɘ`qqqtp{K{"[w (''/]b3 K"A]"1驹(11;lf|x/2[r;/Qt O"@}>PK@[!P--$Ο:ydRRRzzҥKqx>,"=mUI1@ P Mˁbh#2 8…X,S޽xm\S uYRhנEd͐H掎GGG7 +N!P[Ij]֛';ߖOAJ zS)@75kWnnnPPp#@}7Q" ;bNE׸(F]he.,,,--mjj뮻<ĢEl6/@3(> EfSBkD-H׭[GbbbYsIJV瞟?ESz2hNDR(ɓ'VXh4񌞁C ii%vKZ*P֒DJ|l!v3F7D-|x0GDte6mZ\\U?*{ҩۀ&7}c D[5 %/LݯP !>~h:~-B[[[wE7v֛ 4Բ,Ž| qNT* JϓP?|(Ŗ%X‘Qrp;;r{}PrUwyx{xzzR_f>>>3f̸];iu}uQE{$XJ%-"ܹ/zgt i?qpǴ.M?0 Q1M[](X# l6UWE/epiJz5P12c7 XJj^;`F(Jq\c9sf^hUTT$&&cqZvRcW)IMB.nnn3g\|YOL $U&7ȴkV*>>ә]tu]KHhMH/ :P_~E?SSSٳyf(ɉ<}i B:⠸nݺ7x>q(697sܹwmll|^ThuZ>6۩+ŵ5jk|jkkkP_uƌc\SSSWWVUUeـVg*&U8YhkkٳgFmـ&(쾦76|ʔ)8I讜8_MA&D?DK7?n`6ѕmm$6$l8̉'&$$ŋsi b D(U]99`6@Ay{zEyBgc<GŇf ^%iAU\FQƮ}ylOޭ4h3Ua`!$/uPi+FL1cAm Wߒ ;pz/9y̘1nnnAy)Ӧu*+]Neq z3;{ѣkWRBϪUJ@od;)AHUɦӧ@E[ۈqг'|zP 1gѰ̅mmm~~~,3pNd9R PZg8L3ݼܼA q#U!B[qZZZ(B#U{ᗒ`8In5RЍU***8H؁6&[@ q*P_vЎ0dzfh )JrsO&544l/h؄WVbL[oϑ K{-.,; wJ3LÇr-"Lوҥ@*#"5ɒBwne8bʨ>@gf.}B&f6(JWcTRfRr羳@PͅgZUH3A3`{1cLIHa[ù+?'\… IIIfG}[oeffVUU97v&-&$`"!E-8(k֬ZqKKscgps,rbZ@5}i x͒;-,{oʕeeeYYY?,Ւ4,X :5oYX P(@:YJ&BBWss3Uhuuukkkeee]]݅ ܜ;w֠j C((J_ 8Ģ(MzZ^^N)))tRee%!Ĺ.r&E"} I"]A~>e(x4*Vujun,R/?Y 7`n/yH'b8(|űc>cThnHGG 7n-iMk̀?E$d P (,kkz v{XX؃>X^^$vKC_BGH%0u;wYPĝb'0B===90Q8JBBB| @Qzqgǎ73;| !P !漼/[^"f1'E E)ހqz}H9_:Ռ&gvyF'`R(!՛PXI!=rE 0yUf}24ـ2E)<)KW)ti/Hª@bb< Ħ( (}x)]ŕ$QYq%( &j= ܵ te+tQVz *d&ɂ) ^rEikx[j89bECIB PB`1Rw9Vr)7hҡҵ]_3a#ݝހ!2RՄ&. #W6E:^$$Hšt hY9?rmq{S(89ߤ֖\:q `g3yo&º^F@l%DQzRLQ:UY^ͣLe] TpDwg؉ҪA6W/K@gv_&+ )z+JbWa/SH#^a#PQ*777[,}^rE (dF `(t2F!7=okk .//Ij(u)W (S$JW\\Q\\oB*9{]a%LSz뭟ȑ#J^^߾J/{S3iαӑeEk2fi3fx뭷>裵kvttbÇ kkkE/W@9 Hz45g2?Ә3`,M "Qzٳg}O? sZJ9:IgϦyy@Y)J?W;SCŋ6w@ ٚfEfggLʬ,-[-u|ˉ_̬ ٹsGpppw)%YULd2vSvn_x+\|7Jf}mm-v|GGGEE<}n{]bposo㪪6IAlEѾ_WWgZmjmmes*)w唗l6xvvvkkbtRKKZQѾ>_SST^^fWTT(wvTӅl.:thJ^z?EEEC=_rUg}o]ruֱqqqAAA6m*زekF)KiiiO=? ^{^xom3g.]c> $$dΝ~u8?͛wUK _h3ղ˔)S?BϜ9j[˖-իWGDD9rJjvb(?LUV}g4?!!~JOO-HNN:th]]]~~K/DwŸɓ'޽-//߲eŋ/^\\\Li>|[n9|#<1QB***Ϟ=ݻ>rap8Ξ=Ko=z4""#==^PGx񢛛.\o߾znСC{mV^ 8ؾ}+RRRh~RRRBBwYYٹs! K?裏[gժUO>$233Νo^}U.'ΤvܹsҮ\_̚5k… .|_xٳg:488ooll駟:::jjjk׮ɓ'>1""b„ ={,++:ujZZZvvǎ//d//shNse|鄐_|^X|yppp߾}iEEEv}Сaaa7o.,,[vȑ#z]RR2a„Ç/ZGr{=jԨ삂;w>SfJNN^reUU՝w٫Woo߾.\X,Ǐݻ!C7b/r8V5**j׮]ƍ;wnMMn4ig}e8{5}􈈈'O+WcʕꫯZ611رc{?~СCEٷo_rrM覿466Ǐo9a„QF t 7|V9wu_|(JKKK\\\rrrddĉ{QQQA;vӧY-Jݻ{뭷7٬|MMMLL˗׮]vZÑW]]MҦPJ!!!_o(J^^^\\?ӧ[Nz׮]=\kk~_(v=!!gGG+`ٖ-[vm 4O>999<Dy744n6`(Jcccii޽{)[u|{{]veqr-111w}'CBBEiiiihhhjjbkf.**ڻw﫯;vL*g|wܱm۶*=y [WWʬ]v\8*&zPUUuĉ/_7Z[[Lr?-]Tn1bccg̘q]wSS__?`od )3mOcEǓVŋ dɒ#F7꠽o`&ާ8tЁzURRuwFDD\dI$ 믿_jkk1bĂ ܿk#ClN}}>}޽cs!VI~駙[n6(^ﶃtȑ/d2r-Gݴi}th@>̌)SDFFҭ8WJ A@MgΜ4h̙35@ K/$$$ 4o2\(, v endstream endobj 438 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 439 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 438 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16043>> stream x}yXG沨 "(\T5!dL4ƌ$3j2$O2YUd2jb45.#o]r-}>[N:v_to͛m6f?+RRRy_|q$Id#J< UcuN:w>|999'(uJ%R*g(̽{X7HII ܲeKBB–-[6~*TqrqqIJJ!88eFEg삏@$tTfUC=C3gjUlDQu PZZl2"Btta@.$;MMcy1** -[c8Y}J8(y >ɹ|2y>YN)㄄J;l; B"Z,QϜ9C$I|Ǹ:DIlAj&_| <`,OnPN 1c \H5?BQI|CQLX(,1APH4)))!!!/2 %}Fmj9 Sއ1{lUŋZշo_JYdai0? 2oP$i9eRg/QY{߻~ h̟?2:.'YhƺU H\}б8r’)Xݠ#Q'R%@27:E^( Š %d2u-88iܸqk֬),,~ j&˿vmd͛ͭOA'O޽{_%G(A4uuu1^reFF(/҉'MOABZMT™=ʕ+wp@7oޤI:X]jʔ)oߞ;wn~f̘1bĈŋ)`+J$MuuٳkkkƜ9s̙jĈVx)Ȇ+9(xxС / PmouT %}裏{Ǐ)LG`8)cP VUUoCBjIy,nn$ +8+\$M^HLr1cip$IbkkkXXXϞ=H(HP` *ĺ EQ}5ʬ8KoP h.\ؿŎE)CkpHa*uK~JSRgDѣG[[[ii) &M+mR\p`CVspU+~$"⚈JB֤C...6 mݺqӦM&yX$LF ;Յ %sZ~\JTiؾlذ!33bccʸhJZH@)))...|wΎ---X,/^>;{P,gϚLतh*x1:rT0Ņ&L@[lpBzz1c222.^x[eQA*LQ$I[lٽ{^JNNZsNg:ʈNH?7@me$ \wY 7nOznjc4ϝ;g4M&Ӵi6*^Ͽv hii  L#Ftcǎ[VS{-XoFĩK*P5%I 4hPzz޽{׭[Ч2cgE?@pǕ~b?ǡ4W^:u믿(E=ZlZH"ɳK,_~*5uQUlEhh( BmwE%aaa$ݻwKbް/pppZu \"]#< [{PvJ~,ώAؽ{X|vp[zo0/B]Uhp[ JnPEy:JvPիW^Z?i8o8 gWSUyRT N})8=r%kzSr2 q:qGT٫$5(sWj'MS/lJdw2,2/)T;\e$5ǠJx%"6 WjBq=`uHL:"ػܱf^rGu(ID ſOz)?hF*ݻpȑBJd~~ee/.7ǡg!.ݺuN߿.^H}j$M̙;ɒʂsQrzz S >}zLLL]]K~ᇘaP0s&ٺ1-vDDV=գGGGm4322,Y|ƍQ(ɘ1bЫW˗/3fݺu!00aaaTߨ<@'%'''44W^inn ;p@CCzg5,C Gڵko.,,߿ÇF#zۊTԸ:N~!ف[nafϞ]^^D:);0JSOVf]5//Ν;C  ݻ3p$I;U E ill\dIYYٌ3ط?JS%JPt0!%IZ?KT &G^bGdv}$L&BQm9ł8q"<, V̕3g|׍7nR SO=`Xl'RVR/PDoF\… x TmܹV֭[T"KƑ%Rߧ=j8+Bdd`y6)8?C{'O$ĉ\(`W#]$It555*_"< |ldPP"&NNI( 6B1؃Almm6l9V䉾ȹQcjeݠtȴdCH"Cq1\Q](1???++ :^Gz-d`@S(.* =A@%666._|ĉl a_ ;wKe˹˭P:+6`8zWpŢs(REAUrfw)@9XE{Dwww6FcnnnlllMM UAo~KTHQd=VP˗wmZwލ\4.&AH>~kk+BqY}WoEBV^ļg{DӻwjVزejܵkj;w.bgh!ˠy 111&i?~PPbgj 06icv>@ AAA\(gΜɩ^`ABBB``z3cp$x-P#I,)Sdgg[,e˖8p@EbgjU"?%;@FEEt:773f8;;O,B)wH͍8;;Ϛ5kF$jk.qP 4nnn/a؋ǏO~')hD, K(}7հ0Il"vv&dJP{t#ٷ(9`Je%fee_b٤MS VY;E}z=PZt8ĝݽdʔ)4O;~ZZ}sssPP"tJUddt_6|M$??5 裏waSʦEM1V{V:t( %0ɈҪN8hs;<'vzC(; Y1 sjll|cͧssw J$V]r?f[Stq*A~O=e(1z§$ Twd]cbp_ ư>}g]JpLc6Z-~-wxpX+SPcC&+v,Q%ȅF&N"vN%{3!- mgň%%(7"" ](((_Vl޿? :U3o&`"6i۷o;vL7o޻wgvVӐm&Sy?TUU X]]m6B.EtJĜӧOFtuӧOر#)) n߾}Y )X8!Q"WAbbb+ccc 99իTP1^|8r#Gg<'2Ji]ǧ5:::+++"" `0.U]MRUWsB qrr***Zf 2kvSΟ?jzxx0 '"[}o Vٳ ?M'|tfΜ lPα*f$ gt @;6n68MXP_,+MTTݻbaO*C#R. d0(*(`j>$` L?`qҖCQ|(9+VLP>}fѣG477`# 9Бp2.ِkuRy&;dpE=ypN"A93M8*XUU>DNR$!Kxd17&B21O!@2e>ȖyBK-s[ c1yyy ߴRոJF9˼u6jKZA^ J!uf\ '|;~6!UVG])P#GfbX7g9TDF;0"ߙb;0+P<{{~9]͔4ӦM=z… %I*//Ș3g˗u:ݜ9sH8Ul[G}$O@9p|HAZԩSO<~^=*(HL4ܼyS$''~RXƟUl0b;&''… >(m۶Z޽{;v,<<}jO 5āD+ij(R+PȯǛ7o5jT~~^x}jL* Wzwڴ'!Eܾ}{~~;u떘ᑛ  L'_]"Ky+FՖ^bg(**BzQQQXVV>\şړpgfb5Μyn< R+e~~mdaoFt*Gvvv޾}{RRŋcccW]PRjj`8"xyqrhN\\kPPb纺;]x3nMMMMMMz?_'+WZKIs}} +-- 쳛6mZ>|pxxHgQTYPN{Fpɂ 777:f HQz)'2O43#)Cnn{PPPkk(ޓ'OFpsjH aer foo>}L4)44Y)k@]6>>MsoKoÎI,\M%%eIykO Yt_#/:RW㞊---%%%III蜝/H D J%lt T'0-,1[8,;KXST;RQҸ 2 wHtL?n,R$Y(/+BA(RE-J((;ƾSQ½*I+\@u nwT?{رcWQwBczơ3Z- 40uT58˙k%(iiiIssqw @A[U f֬YZLJ`ALܿCdHC3x)'s-BW,{~}.B l4ӧN#uTa}Qk+h%pZp%jPV[!!!T][M hUX47o B,..NMM}'Ϝ93{;]] ´$IǓDs8y$*aLmpݻwy#G#((Ƞo 6[&4oZ9%H 0Q "ISO?4޽{/fmIhfJE3y z H}44\9hEpzxyϚ=MH(LF#fkjjBJ[nt?x𠓓kYYEg"FQp @T8C!vrv޽~< %/lLeM^`HWw䌌%K>|nKa\ot7]n㠒h6eF f<5 @~~~:eҤIfn7f(mw/9t)O$B`W޽{k4A:Ȑ@{@N^(I Jtor R̖K)E(4b\H66+@`0š;+B3)"1{H(.f+%Pa>A Pdg,+DU_%ͅɠS B *j:jw>u'x10?d (N}/qəÇTINN/<8$h/IE:N1Q':CW/zkOv MоEv@HJ k( z1d8ӂ8&ۋ*$3YE J+1UY!i @ s4 SÉO<5/1HS`hlm-h Խ{:EJСCM֫W/t*77w \re3dr9sJAȢ"t#^QXb^M#z F8_zxxpr%$$L6=##|:7^21[7zI5,j9hO>ο벲2//}„ : Ir}*i)eoشiSEEEllg}=j(>> ܘPqʆnR![Ź}}^[o[||ؕS $wM\=.ٳSNmllDlZɩb;HHew\'=8b6~^I [ FeXhTN,,KeeeTTTRRҠA lc%fLJd u ll|PdX}t`v@O^=zSFF~Wr~@&791ad)H.eP[y%zPH|;v$==EE@L&6f4Fc'j#f혲w `HHQN5!CFm`OWc|20PrQov,&H0@д˫ CdJBGk,#|)Q"9jL}&%$&DG;EvPxܹy汝aH*tRHuӱusΗR+VhS\ 'ce$ h(ѣ'N8f̘9sP___QQ1bĈÇcs'G .FUUU!!!Ymm-tdkJK٫d@3VhJJJDQtwwai?,7Ta% ';r)Sh4oׯ__]]}_=??`AǛ‰<nj{)//?~ /PRPWu!m$gKjY /`ƍ999LS < `8@%@#@/. 77Vĸ`0TWW744999$\G[h贲R{UWW 0!2&$P ܫ'|ʍEFw$xJKKuܼ}?y$fNQ!岬ĩD,Ic%I&33s̘1 byft7l6Ϛ5'HJK1Whld~U*H]Bd4 _駟Vs``J51 ;BR"]*%߿_vqWWf$pNJ{g}jF B-@wIt\% 33sӦMׯAѠ Zu/j?YO*]K]z~PKQQ_/٠ TOTnxvaҙWv $%n&^%SJqƍ7mfq5q4#(t EWPغ]n'mNbc`0ۢJ+nfW= .m5 @(ukEd \o,:3fDB n]/Q \Ԏ /t(z2P_{b}"79!;D` 8 .QVgKiFn.$euCy筭:o߾ޏ!5 qU"rftN%%򠱱h4VVVٓ?$^)d ֖p1 " ?y0>---wqq)--%MDCw[O $n F{9Tz$ ~SΟ?CsN/lW\y61L:O?o6l`6z뭼݄Z#@suuu,BM E)))djf:3)4+@whѵp#GzzzYfƌO?kq~0JZ[e+W^ޕWgVg:tK;+gPCOIrssEQAߍ#yAϲWt tTvvvCCCnkMguQ/|pJ(Zׯ_ZVu+V@/~:gॗh.pϼ"NTXXH>Y_WWG=o66zNpG555FQ"\ziXt:$4YKMM` Kl6dJ*++- Y=77`0t{*FI?>jI$f,4LUUUzʆCə3g/_~94Hm=\II rʗ^z4Ǐ?'CjժM6[n ʎf裏%t)==}͚5o6| &>\l~{׮]VJLL?>}:**ҥK$Tiii&?e˖!OŲv#M[ :uJիW㏵<11ʕ+nnnw RRR PXX~6̌8qbxxP "Ν7o޹s׿zdZї%oݺo>|}}+55ܹsfݺu ݊pBppl裏ԅ 233ƍw&09rJZ~8sŋwڵvZPr@nnl駟VXʓuVQQqmAz}aaWyyyQQ~>x'^~eX֝;wgѬO>_8}TB/Ktttzzz}}?7}sΝ;^{wf̘1d___OO'xرcfY>7..hĉÇojj ٳgEEŤIsss_x斒@C4iR^^===޽ꫯN2Ew}wY|o߾}ѧiYYY%%%VuȐ!۷o/..~ǽV#BCC}||"""v=|#88ȑ#5}#G544۷o͚5ӧOOIIYjUMMSO=ګW{o߾iii:ҥK>>>HOOׯ_XX.Xf577ō;6::ZZ '/gL|UTj*RfZȑ#3<&%%]xƍ2d^$ȑ#)))[nE/$)>>ԩSƍߥ?vuu9rdQQ*<~8zYfn۶mը$!!!%%eѢEݺu۱c$Immm)))!!!lUUU]Xcƌqi%h>>>/~ǎֆԖ.]KkoذaÆ 6-???>>+ZVE&LpI )StnP2ŭ[`0߿Ϟ= IjMLLf3`X-[p~0//_t7m2z=fV$555>|QڹsL85cΛ7/<<:_|ϯ@6^BΊb-))9|~ŋ\e?ř3gN8ѫWЧz*88'sHEٳg6gΜA<`ٔnr{N466:t}?pFV(B18v_JX]]U[[snݺ=Ҩw:?~ǎ(Λ7… [nEqy(3> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 441 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 440 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 16853>> stream xy|U?}# [@XduA"U_u+*V[,VAv@IH ;ٓw{ܙ9'l9ϼ=<̜9́bzjt:͛dɒ3g 111qqqׯ-ܢi|q)AM84z΀JJJyޫWDBȬY ODbBGOG`lw)7=R2юsss=ʟR{%ϧ ݻ+** *(d1(n7L盗R*w )E :\^הPTB(J@]vҥiӦ)L9 O1PdbA e9s̡CltN ]QUU%z7V/ 9EZ oxi\WBCBB?5 RP z"C˧Ό|Fu+/~ܹsPrA]lr2ȝ^k?٤$u %pJ25/ 3OR=;-|;A r ԣ CǕϫ ҥKgϞt=L8@bb0GYI^d"ԩS`̜9sȑq\4\UU5{욚1gΜ9sFp8x :qYyGנBs>CxС<]%>f Pg={3={pd(O/KYn%m^L۷o:t(! Bo3H`ʠ L:F )r񼦠gzD-MSJ$%As7P+!t:Y׭[ظj*Hv%"2cܐb>añ}Q`) ,/^aÆRzӋ€}]ʔu???{ΝٰaCIIn/((,E ޭt7AM&*Qf5kڵh޽.]PPpǐ4{uW /C{=!ᄏzM [Vǔ-ė+@)'zP;;s:ӦMׯ_ccti)olz쌚q'NۙNbb0[]XSOM=(Jȑ#CCC̙S[[{]wS\&R{Ue_ܣGŲl2pBĉv;}:50ͣs"eyX7yM@Ub:#+C !1MyJ`^K(*MVȑ#$É[_ 4{P¨ JES$JGw~xz enhhիWCCp  /DF@AY*Z;~TOXd -C9)]lX L*++۷c=2pu{ X@ ('BysQ,/=Z'\P戈ѣG7{{ĉEUWW?F婮KSJJJ~Bc>Plz^G:?tvv&$$Ϛ5KzP$GER2]zJvCeee;6;;ui/ c2^Nآsڵ7onjj>~YYYyTT]{vxx&_J e>~i~߱lկXɓ'?#]{|4O9IQڋNP ,eĈ˗/jMDdPeSab0LSo6yC^oc\H)((mÆ BI&z% mH_e-A{$! .$+cPy˗/ˠ#5VW*{S(UP2w#v*;; 6L[FR /FJ"^V_ @p @VF2z?cOCA>;1>,߿?O[;Sn ĻOPf\wC7hz ɉw07CUK)d)~[R/כ!ƒROt e3\@y⪄m`+-BDk+ +A鹺n4>Z%5eBol֭R~q!k ]p!-- Ν;^GF^7zO?gGpoJ"BzW/R׭[gXu[nky"#lڴI3fYW^G?f͚-l23iȤI߾صkWpp~3####;;{…Nr P @=z8zرc}[1B絁@<׊s痛_yĈ_}UCC۳Gh !%Xc%gX,N8?^z;v舋$JJ7yW ={d2?tΞ=LwRa̧o?MYvs΅2W^񑑑3g qx2ʎnМJ(%B^^ŋ.\XZZ:sLy'YSG;/GR H>k9܊<{2|uuuR0/@ %% w%''Kx %(\軡^1"4@gLxGe#to22 LD9r #^;x=(0Qvo^CT|Y8 Ak r)B?0"KJ(ş$)c(heezWF?A4#+]^ViH /HY+J< J9|((ui eZh}j' M`Zvs mq=yAJS3šjcYyCq(ѣGv:33wߵZiiioVSSz@Zn3"߿>hll|vڥ*03 ^z)33^:y򤌩gY :P^ztMY|999/_NOOg@>|x֭|D5ҜBsa5U)Ś5kJJJ6nn޽{߾}xlB j׮]yqqMQjj*$TxJcd:t({Up$&&FFF;Bj4kC&!366O>Ce;+ߕ65\aaaYYY ,`788x֬YÇd}+Rr gIMMvgm,eO;3gJNdz%%6v@^B,KuuuZZAფ қ*GJDYWBDratNu +LÆ (X Tjt4@*RVC 6JC0Rb*ϡA/6gL.]b[p_êg$Y]PJe^fYV1=|u g=v/i %; ŋT(3>}zwlӽ𴣞j%B.?λrbk=6+V[r~llo J8%!Ŝ|a"WZ)d0i? X""#vt?׌D!{D%# 1p?q`hOYf/^XdIqqÇ.8:nCr;BܐRzرW.Z?g . /ɭgs 0ŏ\2{=$%%}GPHM0ƬPȪ*`+k:M69s̳=䚼7Ȥiy5ktvv>|˖-͋L8/gn, $y{ǚ^ٿnnnUUw(~ VOvB7&J X/0uԘ#L&n'\D@AKь( O˥LTE)5KK̠J(smmҥK}+VHB -"CIΤJEy>i({D/݅\RMYE/WKӟzV.,Ϻ@)QUAm6[mmlwFGhjnPz@Ųdƌ3f(nW"#fJ*nZin+"@)#^.p6Z~;X]A 55Č?>""rӧxJ)R3LqcTU=pȝ+xÏ?X^^~w>}=]"c4QBYlvwNf (yϟ?wiiiGPq xyb/L}GG;nݺ|Izz:R਋"M>!d͚5l 6?@ii pۉ eJOG_9rUVUTTs zQ"-k2ԩSlcg4h ޽{TWW#% ~H:߿W\>|8{7&&!+o8A!]݉й !ѭ))).]?~ 4btizSXXb fЧ~.Λ7pܥtȳt 0]L[n˱T(y6lؿonCO@Ð}KJI4y䎎\*ç1 K98k.F>^7 QVOp`,B$S'X [ LcƌILLlnn6+D1FрKH*&G$2!R1NtSy(]AqFPj̕]”m`kãJى?NYɑj_[-ylabڞ\:.}̘1s,;;{Μ9GX,s;)]G9kH9Ay !999ӦMۻwo@@@l2߻S`O>m6322fϞ-(AeaQC2:t(66xSSSϝ;Q]]m작jJn y&@ W~w}^;D%0{sI tl6[`` {G8ZY (G?*hĕP]2;wvv666={\uݵ'|A|/C+< ū޽k/ \LC<9!cW^]z1xJC"\+Ν5k֋/ M<裞l*,L,d4J裏[tݵ|-\~yfv๱8#U dTw,ԠLŋA`z(6r㪡;S#"D3=ƞ th~饗^z%U}AHQC 5>T'61?zKvOJBVf HNꎢgUڊ<3*tb~<7~W! IWPMTPfaƛ@\* UV(#W,:|<0=|0ك4}MY\܀@hP 1YsO g$r]WȤ(vV"NgX@PGR ^T6J؎XUN0.??{g<;DWnOȒQF>}Z^i)ݸD 2>|&/BEEoFfx9 ~+Xy@d%\r۵kWvvSO=UZZОx9ooGzzzqq7yNIIɪU6o\YYkUV^)6gdTxslslxav-Z$@Y1c_>==ڰaC߾}ӯ_ uәoG[ԥ[ZCBxJ~JJfOVksssUUjmjjϴy60Q,B._\RRez7J/?~rƌ.\7n'xBX Vo2dt:}||ab;(R9f2onM6XԻYS,ZfԈjM\#b0wUP”X>_2z|jsIS6pJ&#heY ↡X!2%(P#GtҚ5kZZZ =5^_΢Lo?>;;#G֯_oۻ"TXNMi % ;J+WE tY;_ӧw}WXXȾ +0{)ïR2dSO=URR2f̘;v P( g\C"n42zP)x^eFVT5l(FU#n$@L^+'1oO>ݵdt%4_Q_g"xFj]f\c(\lS!'BΝՄΕxP6TB/Az4gXzPPRAQ'MMMl!{ĉE>}z…Y$ƣ:ud[l1bDhh\1 =L `Ve x瞘wyy2Y ̡{a(k׮5jԶm۾)S?~<,,=(,!)y}N*񖗵k׶ :tժU3go~뭷E 6DAAh6'؇>%Odd$SL!577:tL_D Hm"+ a$///$$$>>d2DEEM2+P'+P X\@FIqÇϛ79**gϞ7|sRRR<1HaaڵkO~hl)x-4xվ$wnÑ'j*Z+Y6{ٳ'99(K)C)uL---`,&8U7xp!RY.OW;1QRJMaV [GK$Urf=) 8((H3%:|.VP %+J8+G/vPG, r5TTTTQQa2^I(6MϠ<=T%zվ.Ѳ8N$ZJ:\SS\,- {OJfpM7ݤ=Bkvv%& 4y^_;^ҭ}{.޺|({5'Խ _x Hr…o}Ν.r:P_/|45c]gAP ؀.O?t޼y}Yםr2fh2Y%2L&ivn:ҿ[WTTX;jg5yxf͚^zm޼0|{ОL|:Sz>.y^A]{B?p;vt}70}*\`(D9lǖo)44*v,LMTzAdddllf4h{&44̓Xy=LY#.qk~wنcƌ (((`4Jpt24(sQQQYYYKK˂ @Њ=G4_v[߈zrhʴi#l/_>| _PTm'Nl_=MJ+U퇿ɡޞ6vcQziv{bhc\|BG)<+s9((6StttE)moookkKd. @)qZOA8` tز%n TQY[{ /6QBɽKۏ4#$4mڴ{W1ъ'o lm.Xa0tOV0n"N a⸄&8)(CJ/#ڠW(uGq5&YgƗ?-0(kצ>5>TB&G6][@rhXZ-I;:vAg%?v(A`E[};{[Fhv4amsb'`N&N43YkvJƁ^СCOޣGv2//oƌcǎM8*ٿ?96'9J#qwԷyCUbG޵XB=2pוZ3ZC2-} dfEUSğP+%-]Tw=}~ko{;;C)#tz-{'!M$\&1(SAA p֭[ׯ_bB BtthDEO=2Ky-ywzVzתz뭣GX"A-<|5`?,LՀ]*'AH(a[lYrj}g\*b?BFE (]eޥXځvlMȰNgkkkmmmCCOuun]G]mi&7#DH ]XaB8ەx{{ٳgv{򥇘(X>J4I/e6mAk ՃU0ͱ2_)Np9q:斖&[o{1 pX[:)-'d VxqS;sҥهI#`%$(&G ɳRuXtXK@d={C6Ռ.~L yJc?e)w4F^NBX5>jhP?J&RNW(-rÕ, {R[SU| #"gvyDG[^zjU EguF0?0V}&dЁOK]Ə>y ]w ). {!),@Aض--* G" m4&`$!%8]43VU2%7+'` @@@@kk+pc"~D(A|)eWc{T/mKAz ^|Y L̔nV"}?7!53Q%1*@{PZNa 0uq+)) lnn^~kw@i Hi4;_(XQ뺝.VF͇q/;׿5sիWv뭷6C0* fvi4Ji!c*t:veЋ]:~/~QQQ"#voBxVl: Li(!UXmV%ź[ H4T_~%!tٳ$_FB 8K nQ'Y+W\xqժUfshh_PPPxx߼0õ} z(mb&J/=p5KIBCC{m%l40VRD%J{*fR b&4pFeȠ=zW39YPZͱb7@_/lpTͱ{骼+kJ!vpR!vJAC Bnbb| X ỳulᆭ'berڃOrPicg8=X¬QrTW<$%6 6 Pz6JہO79^׿&H`.VPړ@JnݟBBgv(A@'h3%6] j`"KH)5`!=@JX<okl f*ܵZ%Ai6!czX8D AU,uI-e|țDXցh)rSDV4У(~1ًPJ}lמQPCp g08Z\ı: ii||lL67_ol?WUl=H4c5W]jeN}N{طo_Qjkiٝ۷oj@:@:IД+V̜9xǏ I)ΐB+ V7DjzUWv؁Օ֖ٔ~˗[bU,6 Ѽ.7<9}@?p8'Ot8cK,. =f5oA]1ijj*,,X,VիxN)6O6\l9b[quuuGG央b655ivbh Sөi 䔊 gkooX,/_nkkӲtttXVs`mm-äf񉝝T(Oބ]ф|A߿xvej/b^sҥ?x}}=o?_*''gٲeVmn:r; 6꫌;bŊ{Wpĉn*@=_|_wnٲҲN[~'4+g~'O>rURR2}t7|GaSO=pA+0Ӑ---3L˗/cǎdgg9sfȐ! W^}\xq۶m&MJNNꫯXފ 6\xq%%%ƁWjjjhaɳgرc{|+33졠gϲC%$$lW_튖x񢏏ϸqN>ϟ?{;w.]m`=ЦMz)p4J<駟.Y$33gdd㏄WFDDj/{O<^p86nسg˗?䓬ə5k믿+"}FN9)))55n5kVmm0a e;85uԄǏe˖Nsٲe;w|A7==[n7nܐ!C(;w===n뮻Qʕ+|+WPJښZZZe555;vxWZZZ>Ç+?{ 7o4i-2k,SO=p䧞z455A9JOan>۴iSuu|7{nhhux㍩S QYAuuѣGǍx{D@hoo}zӧOn RYy6--m?p]PP. endstream endobj 442 0 obj << /Type /Page /Parent 3 0 R /Annots [ 446 0 R 452 0 R 458 0 R 464 0 R 470 0 R 476 0 R 482 0 R 488 0 R 494 0 R ] /Contents 443 0 R >> endobj 443 0 obj << /Length 11893 >> stream q 15.000 30.318 577.500 746.682 re W n 0.965 0.965 0.965 rg 26.250 703.305 555.000 73.695 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 703.305 m 581.250 703.305 l 581.250 704.055 l 26.250 704.055 l f q 35.250 714.555 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 766.011 Td /F4 9.8 Tf [(Figure S7. Optimal vaccine allocation for different numbers of vaccine batches for )] TJ ET q 47.250 0 0 13.500 417.781 763.500 cm /I178 Do Q BT 465.031 766.011 Td /F4 9.8 Tf [( and deaths averted.)] TJ ET BT 35.250 752.275 Td /F1 9.8 Tf [(The delivery schedules consist of from 1 to 8 batches of vaccine delivered in intervals of 1 week, with the first batch being )] TJ ET BT 35.250 738.538 Td /F1 9.8 Tf [(45M doses and subsequent batches being 20M doses. Each graph shows the optimal allocation given the number of )] TJ ET BT 35.250 724.802 Td /F1 9.8 Tf [(batches of vaccine available.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 493.860 555.000 201.945 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 695.805 m 581.250 695.805 l 581.250 695.055 l 26.250 695.055 l f 26.250 493.860 m 581.250 493.860 l 581.250 494.610 l 26.250 494.610 l f q 112.500 0 0 112.500 35.250 573.555 cm /I180 Do Q q 35.250 505.110 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 556.566 Td /F4 9.8 Tf [(Figure S8. Optimal vaccine allocation for different numbers of vaccine batches for )] TJ ET q 47.250 0 0 13.500 417.781 554.055 cm /I182 Do Q BT 465.031 556.566 Td /F4 9.8 Tf [( and hospitalizations )] TJ ET BT 35.250 542.830 Td /F4 9.8 Tf [(averted.)] TJ ET BT 72.641 542.830 Td /F1 9.8 Tf [( The delivery schedules consist of from 1 to 8 batches of vaccine delivered in intervals of 1 week, with the first )] TJ ET BT 35.250 529.093 Td /F1 9.8 Tf [(batch being 45M doses and subsequent batches being 20M doses. Each graph shows the optimal allocation given the )] TJ ET BT 35.250 515.357 Td /F1 9.8 Tf [(number of batches of vaccine available.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 284.415 555.000 201.945 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 486.360 m 581.250 486.360 l 581.250 485.610 l 26.250 485.610 l f 26.250 284.415 m 581.250 284.415 l 581.250 285.165 l 26.250 285.165 l f q 112.500 0 0 112.500 35.250 364.110 cm /I184 Do Q q 35.250 295.665 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 347.121 Td /F4 9.8 Tf [(Figure S9. Optimal vaccine allocation for different numbers of vaccine batches for )] TJ ET q 48.000 0 0 13.500 417.781 344.610 cm /I186 Do Q BT 465.781 347.121 Td /F4 9.8 Tf [( and deaths averted.)] TJ ET BT 35.250 333.385 Td /F1 9.8 Tf [(The delivery schedules consist of from 1 to 8 batches of vaccine delivered in intervals of 1 week, with the first batch being )] TJ ET BT 35.250 319.648 Td /F1 9.8 Tf [(45M doses and subsequent batches being 20M doses. Each graph shows the optimal allocation given the number of )] TJ ET BT 35.250 305.912 Td /F1 9.8 Tf [(batches of vaccine available.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 74.970 555.000 201.945 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 276.915 m 581.250 276.915 l 581.250 276.165 l 26.250 276.165 l f 26.250 74.970 m 581.250 74.970 l 581.250 75.720 l 26.250 75.720 l f q 112.500 0 0 112.500 35.250 154.665 cm /I188 Do Q q 35.250 86.220 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 137.676 Td /F4 9.8 Tf [(Figure S10. Optimal vaccine allocation for different numbers of vaccine batches for and hospitalizations averted.)] TJ ET BT 35.250 123.940 Td /F1 9.8 Tf [(The delivery schedules consist of from 1 to 8 batches of vaccine delivered in intervals of 1 week, with the first batch being )] TJ ET BT 35.250 110.203 Td /F1 9.8 Tf [(45M doses and subsequent batches being 20M doses. Each graph shows the optimal allocation given the number of )] TJ ET BT 35.250 96.467 Td /F1 9.8 Tf [(batches of vaccine available.)] TJ ET Q Q q 15.000 30.318 577.500 746.682 re W n 0.965 0.965 0.965 rg 26.250 703.305 555.000 73.695 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 703.305 m 581.250 703.305 l 581.250 704.055 l 26.250 704.055 l f q 35.250 714.555 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 766.011 Td /F4 9.8 Tf [(Figure S7. Optimal vaccine allocation for different numbers of vaccine batches for )] TJ ET q 47.250 0 0 13.500 417.781 763.500 cm /I190 Do Q BT 465.031 766.011 Td /F4 9.8 Tf [( and deaths averted.)] TJ ET BT 35.250 752.275 Td /F1 9.8 Tf [(The delivery schedules consist of from 1 to 8 batches of vaccine delivered in intervals of 1 week, with the first batch being )] TJ ET BT 35.250 738.538 Td /F1 9.8 Tf [(45M doses and subsequent batches being 20M doses. Each graph shows the optimal allocation given the number of )] TJ ET BT 35.250 724.802 Td /F1 9.8 Tf [(batches of vaccine available.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 493.860 555.000 201.945 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 695.805 m 581.250 695.805 l 581.250 695.055 l 26.250 695.055 l f 26.250 493.860 m 581.250 493.860 l 581.250 494.610 l 26.250 494.610 l f q 112.500 0 0 112.500 35.250 573.555 cm /I192 Do Q q 35.250 505.110 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 556.566 Td /F4 9.8 Tf [(Figure S8. Optimal vaccine allocation for different numbers of vaccine batches for )] TJ ET q 47.250 0 0 13.500 417.781 554.055 cm /I194 Do Q BT 465.031 556.566 Td /F4 9.8 Tf [( and hospitalizations )] TJ ET BT 35.250 542.830 Td /F4 9.8 Tf [(averted.)] TJ ET BT 72.641 542.830 Td /F1 9.8 Tf [( The delivery schedules consist of from 1 to 8 batches of vaccine delivered in intervals of 1 week, with the first )] TJ ET BT 35.250 529.093 Td /F1 9.8 Tf [(batch being 45M doses and subsequent batches being 20M doses. Each graph shows the optimal allocation given the )] TJ ET BT 35.250 515.357 Td /F1 9.8 Tf [(number of batches of vaccine available.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 284.415 555.000 201.945 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 486.360 m 581.250 486.360 l 581.250 485.610 l 26.250 485.610 l f 26.250 284.415 m 581.250 284.415 l 581.250 285.165 l 26.250 285.165 l f q 112.500 0 0 112.500 35.250 364.110 cm /I196 Do Q q 35.250 295.665 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 347.121 Td /F4 9.8 Tf [(Figure S9. Optimal vaccine allocation for different numbers of vaccine batches for )] TJ ET q 48.000 0 0 13.500 417.781 344.610 cm /I198 Do Q BT 465.781 347.121 Td /F4 9.8 Tf [( and deaths averted.)] TJ ET BT 35.250 333.385 Td /F1 9.8 Tf [(The delivery schedules consist of from 1 to 8 batches of vaccine delivered in intervals of 1 week, with the first batch being )] TJ ET BT 35.250 319.648 Td /F1 9.8 Tf [(45M doses and subsequent batches being 20M doses. Each graph shows the optimal allocation given the number of )] TJ ET BT 35.250 305.912 Td /F1 9.8 Tf [(batches of vaccine available.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 74.970 555.000 201.945 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 276.915 m 581.250 276.915 l 581.250 276.165 l 26.250 276.165 l f 26.250 74.970 m 581.250 74.970 l 581.250 75.720 l 26.250 75.720 l f q 112.500 0 0 112.500 35.250 154.665 cm /I200 Do Q q 35.250 86.220 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 137.676 Td /F4 9.8 Tf [(Figure S10. Optimal vaccine allocation for different numbers of vaccine batches for and hospitalizations averted.)] TJ ET BT 35.250 123.940 Td /F1 9.8 Tf [(The delivery schedules consist of from 1 to 8 batches of vaccine delivered in intervals of 1 week, with the first batch being )] TJ ET BT 35.250 110.203 Td /F1 9.8 Tf [(45M doses and subsequent batches being 20M doses. Each graph shows the optimal allocation given the number of )] TJ ET BT 35.250 96.467 Td /F1 9.8 Tf [(batches of vaccine available.)] TJ ET Q Q q 15.000 30.318 577.500 746.682 re W n 0.965 0.965 0.965 rg 26.250 703.305 555.000 73.695 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 703.305 m 581.250 703.305 l 581.250 704.055 l 26.250 704.055 l f q 35.250 714.555 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 766.011 Td /F4 9.8 Tf [(Figure S7. Optimal vaccine allocation for different numbers of vaccine batches for )] TJ ET q 47.250 0 0 13.500 417.781 763.500 cm /I202 Do Q BT 465.031 766.011 Td /F4 9.8 Tf [( and deaths averted.)] TJ ET BT 35.250 752.275 Td /F1 9.8 Tf [(The delivery schedules consist of from 1 to 8 batches of vaccine delivered in intervals of 1 week, with the first batch being )] TJ ET BT 35.250 738.538 Td /F1 9.8 Tf [(45M doses and subsequent batches being 20M doses. Each graph shows the optimal allocation given the number of )] TJ ET BT 35.250 724.802 Td /F1 9.8 Tf [(batches of vaccine available.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 493.860 555.000 201.945 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 695.805 m 581.250 695.805 l 581.250 695.055 l 26.250 695.055 l f 26.250 493.860 m 581.250 493.860 l 581.250 494.610 l 26.250 494.610 l f q 112.500 0 0 112.500 35.250 573.555 cm /I204 Do Q q 35.250 505.110 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 556.566 Td /F4 9.8 Tf [(Figure S8. Optimal vaccine allocation for different numbers of vaccine batches for )] TJ ET q 47.250 0 0 13.500 417.781 554.055 cm /I206 Do Q BT 465.031 556.566 Td /F4 9.8 Tf [( and hospitalizations )] TJ ET BT 35.250 542.830 Td /F4 9.8 Tf [(averted.)] TJ ET BT 72.641 542.830 Td /F1 9.8 Tf [( The delivery schedules consist of from 1 to 8 batches of vaccine delivered in intervals of 1 week, with the first )] TJ ET BT 35.250 529.093 Td /F1 9.8 Tf [(batch being 45M doses and subsequent batches being 20M doses. Each graph shows the optimal allocation given the )] TJ ET BT 35.250 515.357 Td /F1 9.8 Tf [(number of batches of vaccine available.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 284.415 555.000 201.945 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 486.360 m 581.250 486.360 l 581.250 485.610 l 26.250 485.610 l f 26.250 284.415 m 581.250 284.415 l 581.250 285.165 l 26.250 285.165 l f q 112.500 0 0 112.500 35.250 364.110 cm /I208 Do Q q 35.250 295.665 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 347.121 Td /F4 9.8 Tf [(Figure S9. Optimal vaccine allocation for different numbers of vaccine batches for )] TJ ET q 48.000 0 0 13.500 417.781 344.610 cm /I210 Do Q BT 465.781 347.121 Td /F4 9.8 Tf [( and deaths averted.)] TJ ET BT 35.250 333.385 Td /F1 9.8 Tf [(The delivery schedules consist of from 1 to 8 batches of vaccine delivered in intervals of 1 week, with the first batch being )] TJ ET BT 35.250 319.648 Td /F1 9.8 Tf [(45M doses and subsequent batches being 20M doses. Each graph shows the optimal allocation given the number of )] TJ ET BT 35.250 305.912 Td /F1 9.8 Tf [(batches of vaccine available.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 74.970 555.000 201.945 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 276.915 m 581.250 276.915 l 581.250 276.165 l 26.250 276.165 l f 26.250 74.970 m 581.250 74.970 l 581.250 75.720 l 26.250 75.720 l f q 112.500 0 0 112.500 35.250 154.665 cm /I212 Do Q q 35.250 86.220 537.000 62.445 re W n 0.271 0.267 0.267 rg BT 35.250 137.676 Td /F4 9.8 Tf [(Figure S10. Optimal vaccine allocation for different numbers of vaccine batches for and hospitalizations averted.)] TJ ET BT 35.250 123.940 Td /F1 9.8 Tf [(The delivery schedules consist of from 1 to 8 batches of vaccine delivered in intervals of 1 week, with the first batch being )] TJ ET BT 35.250 110.203 Td /F1 9.8 Tf [(45M doses and subsequent batches being 20M doses. Each graph shows the optimal allocation given the number of )] TJ ET BT 35.250 96.467 Td /F1 9.8 Tf [(batches of vaccine available.)] TJ ET Q Q q 112.500 0 0 112.500 35.250 573.555 cm /I214 Do Q q 112.500 0 0 112.500 35.250 364.110 cm /I216 Do Q q 112.500 0 0 112.500 35.250 154.665 cm /I218 Do Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(6)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Influenza)] TJ ET Q endstream endobj 444 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 383>> stream 8c`0b ul;7c B*fXm%1 `;$k՝5e{)80<.4ܦAx@T߅ oWlK s@R6bAW1猞Jц TA  ~I0SUsSĤ H`ѿ 8${8x|Vt.̹`,{&Gҏd0֜3@r) ufLdDa?`cB׀T@I?KO(@3DaCL CB?вYu$I "Y _p+eapraS#pV VDI ltׯ4%|@C( # endstream endobj 445 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /SMask 444 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om_x \ endstream endobj 446 0 obj << /Type /Annot /Subtype /Link /A 447 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 573.5550 147.7500 686.0550 ] >> endobj 447 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coveragehospitalizations17.png) >> endobj 448 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 449 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 448 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 17224>> stream xyxTEV'$!!aK6(((#*2:DQPGQe\QttdP( lY"$I'ꪺ7:'ܮ{ꭷN:u{aXy晕+W:N9gΜ|0==OLL~衇kJ) HU):RM֙>ϯaaa#G4L{/%1J);`>j%,;ݻw|||ttt\\\lll߾}{ 7hj+:JP(ӿn3!!2cƌCSx~P>S8l?SEϳL㜜G@ɾ/傂vsr U dM&Ӿ}ᥔHk% z |ӂkW5e/Qb%X(ӕ+W.\0yd"A)\pqPBu{>Pʠ2LL61ALң" z:]kPҕ'QvyC{{{eepVJ((Zj 4Ku] e 6bHC)/ e/:e#OW|5{l%1\n oLk?<(L.dNP#F|Wݺu3ʯR=?͊8A rވ!\K=h\c J(sGGG```||H9!!ӓW\aÆ3f;v,-?%~<3R0<'ukժU7x?nܸ 3P2!!C<@@x(շ~[SSe͖zp\hK %00n3E%%%L~x̘1 ̸GNBgucaYh̙3͛7~x ,e'y~hP&M۷?mڴÇp'ЃZJ(see̙3ƬYf͚>|X-e]y=!CBrss5+w)@Tf{+vő<%-eO\ty1UTTlݺuȐ!f B M8A%AH:EGV˾8֒y^S+TC=v % kry~J`%RBN'+:{5kZ[[VX!ȎdW-"3- J(֭s8[n&J{B9o"믿~y֭+--ΫW>X*,x< L~~~ʕ+Ϝ9nݺݞrY3j[nLT֫VڱcGQQў={.\ ?"!i".;@^ ɇMzBݻ 6lؐgϞ˗ʹ1 PJ;);;oniia}[bccNɓ ]{C@Eh);&7|㫫o&dV~SGR:|Yfz뭭1.=CޯeX,/f ,N?nCn"39~'?ĉ.Lx7c(2 &^prR4rȼJ^ZlDSzR_4q( ΐbePʼAʔ4evikaGDl)E:#+C ?!1MyJ`^K(*Pfz$É[_X 4{Pª /J_ESy9$J#G66{w\__߳gz9tZ=D%^x:H9 e-~ ?S=c1[r:חuUb22ػwm'`M}W0$Ͽ_ +{B[^BgN#G3f ''ĉ .LMMS]?-魗J51'Oy)))T_6 3[o #TQ;::<8c [AITTTTPPJzCeff=:++ui/ k2^Nآq7nlll8qbZZ࣡)x¼A >䓷z+"""22mP^ˇ֑R1hll~ɓz)VGa'Nx}q+IHi2IQڋNP $))RzEWOADU2N[M7K{iȹ`+=(SPPPkku>^OZEQېFvɰK(IjaCZ<\JIF wƠ]=(%K,YWA%FjTQP2O#v*++ :T/r oFJ"W~N[@2};d=>zDŽOCA&=;! >(ׯO[+S. ĹO^Pf\WKꪷhz Ʌwn@/NR")XR/A)':s@2B>pr:#'J(0 "D|뒏A_RP& !h֭._yf}y~asΥؾ}{AA{]2-FP>e|8Vz;gVfү_͛7WTTp Xӽ 6([:uUjkk{yȑ߫VjnpzN5#L;vp˨QҲ,XvA]}Nzc~C Vg1_^xbbb,KssstttYYY꫐W0yT*k:wn6+++-_luڢEd133orJ}}9sϟc~>>>J #3yGe^B]XRH%Bubx?h+^@7P&M@A86fe9D71z(/'Bm(ܹ=FΡeD> + 1)y9*S8q]vmmmB*(YJ9}II gݷo/+]~K/.?zѣ}ٶ͛7%%%ɗB36"e#@Brrr?555%%%}7la0d<`A\b8q?\PPЯ_m۶B%_y>}d2;tΜ9Og>iʲ9s&44t={޽iӴFyr J{ N6MG;%c~:A㫯?҄ځF?%"^ 3_mm-{'&PB my %޽;99gϞBu^K(D@>@ O^5 d;rP(3T1xI5<3 d˅^VW0z7jD9P&~Hx PeX.'")ȭ_pxުVBix(%I! C)W+(/}h' M9`Zuk cq?yAJS3šcYyC9 g322y՚o666(J8ma1k}w}wǎZ|,3_H=wf6%\ JhK(m@^B,KUUUjjAფ қ*GJDYW]BDrauNu +L---YYYC(X Tjt@*RvC 1JC0Rb*ϥA/6P .-8afu(%.k٬VR~҂Bsss[[4^sCC<~BYԩSGK=큧|Vs(,jUy{[1-]$蒳>of8_cSEwo}7x`=&P)9%Ç[,j@8䒫 }42oc=fy&$$$ K&*홈)WC{搐6>|ZZڃ>X\\|[o.=c#TA )ǎ+((Xp_~ɾ/̿D6v6$?r[*zμy?dȏB[wU2ƬPݻWVV[^p7nÆ cH\7fRA^G^jUGGǰa6m4gΜ8kPRdA K>Ⱦ}rrr*++ΝsXOC`i!A/DySh^{l4iRttnL&qE.1DR4# 'N5jT@@i|}}͇o@V/ ӧO߿bb̾svR,zPʎXCi.++ ȸ{!<q^:TyŗΧ~MJJM&5^+ 0`G}ĎWZE)ݽ{wJ(bDC.\PTT4g 8+} %2`(]C :<ˠo}4+$$%+5 M>t_tfᦛ5ݛE+Q֮];w^z9>F.C1'<A(ٳAsrr~5k455%&&9s;,--jN٦( !dժU FZn7 q̙p80RSC\;޺^c:7p\ LY"'P=t/}ѹS00d҃#AH´b?)L'Nloo?{^g2Ge=&6B:˧e ֩SfsTTTZZ̙3vFdeQʔsСvKII9sLҪ1]?S5Yr;лw[_pܵ('2o/%T]l4pTBࣄr'8:Q\~\ ِ544/Wfs"㊱tQE37,,xΝ5Ĵ2<τc!y"\.©\GKK1NIJm)|{O5]Qce%3g̘1cٲeu~lH倠H_zVVʇ~H׷SeÇ%/sTUUK_%׿cqFv๱GFWYeyeӵ£ՆPJuBwFjXΟ?ꫯ.[̻uB:[+ ![Q.:T;xG8uj;52rG2lej,oq~S)"//Nl@rw ERf4:jB닐N+P $P'V!c~10UFI3`e89N x$Sm(/3F=ihwc4FOWU8d%*JPPB]Ƽz]ojNEi&{|@L'kVgSHO=!\$x+)]ܘ*m v T;թ v}kLtKMƧE>]ݤCUNȟU]S2!_7FLAOћA`SB\c)3ܨI0MuuS!uuu[۾ZE" Q[;T QJJJ233:uEY%W>>RǢ+wzVyV8 iAZ_ͦ~|OeC('EAwфSJ5A) ,<+@b(e OT$tȑ#.\j*wiYg@Oח(gϞpȑk.ySC .N۷Ϝ9U/QB)]ꪠ:7v$,,G^lYyyy޽w]XX~;o@V`R_뛙9x'xdԨQ۶m4hPGӆA}Q*q ;v8W߶*J tD,t~9sӧ TXXx]w =⪝KwdqqqVVo喚뮻N #ް ~)x555gΜ2dHnnٳgixM/cAD=QCBc&l'o4_%Ta?&uYs-FX8-{PWNAZTx*T* ҫ_ =(Ncl{P&2B0H(3!bBP=(G 2 @ +OZ6GՑx1 P<E97I`n ߀2[SLyWdUכdYaѥTwJn:3qHPٳg}5s./0mЄ 98PJ1:d<%9""&8qb…999NZ`aCyV>sx('O,));wMBCCaGazPߝ}mE0 ^`1{o޼yџ|-ܢGހlc5vj]Oh6!@1vTshhh^իGe˖o?~xn؃ŒB?甡RoyYzuss!CVX1mڴ{,55m|B='h`ZC8{lIIɽ޻b 1hРm۶%''_{zWң;~1!hdb^n]=AѣG䴷'$$$'';v֬Y.R"k>|b6mbԩ]w0'ѷo_y7N6f[zgwv @u2PPhw}ʕxGĉ-Zp8Ο?/t[hU62^x8ydBHnnKٺw|J҇Dس Z~=ڵߵqeRC@ +ajnn...>x𠖃sM<¯fe3xe6+PP B*ՔN DQf3LAAA)~$P :|e(aZȳJVXiPYR? *wm  0&DPs?عJ{y`>}zMMMTTyWUU}^oIIx, f*ߖ}!)<^҅Z+@A#(4UKv  }jZ6f4 SN1 eddq/_޷o_Y>}@ Fܹs7tۃQӎ||Y棩<[ڛfvb~gs޽s 0SG@Tt&tZVfү_͛7o;X- Wj`ժU={ܸqA)^E“~8r!VAmNz]cc@q! * h{r񴴴 l۶ws!F~}_g8m%6G3ʙgP1vip 9,,,99ZLLbinnPk:s|\[V36yr$%OHwн{wl5dȐn>5EM"8\___.`у{b7%؆SN Ϗ=x䀀::FPJH;p19< :p/EEE/_nnn?>{N6gGX ,'I?.b v Jqeu@)_0^i4@Z#_ RtX !.VGJ2<tgzMAv$!N!az3:)S:&U'%&YƊYn ń-s2 J͔v^ 7uHIc* AUÙ?Pf3_-[v5d7~,DH%@`%!j$_Lki!iKI9((hɷ~c uFhLԤ(T²'HOAw{kNJ'|HIEd2bq]J Gp^_WNr{xNX~*fI@h&$H"#.7w9 AN Xgp YI P z \6؀(0P_ IS'6n]Jw!CL2%<<͝:u*!رcǏZ@$h8@0 mނ p(/+H~~~}}q ^:Li10P *҆.yM $22"L B(ON;w2eJHHHVVV߾}ݽQZ !@άŮ10q"!!  }:Y”?h|ɹs6o޼vZ(E؁BJO=Sa "h 㧜+VxW+++|ͣGX"I1@!`#J:Z$i"IJk?M/_nZ}K.*rz@`ʔ錛jt=LZ87+a'ONgKKKMMM}}OUUn\%fBzi@_BLDAZ+c(pz(KHf/yCLi ]1^{hE G v;{t aG-T1XEs5B f617|yʍ7C9(`(pRZFJ4-m (37ٳg͍ڳtBgD(^MLh3+A ̸qO;w.:/c}4VB2`p<+u @f_fΜٻwoM敠< }.5RXwPjh.#(US Q @xOSd)=UoeG ©/`9V&F^ ,) +{uIȘ2R!|n춴:G;؎ P% _zPFH7J[-NU 8+sQQQ{{;{8S9^`R !~@,`:Y(>}:#[[=M(-#U32Z[n+o )ןēUp=`" reK#*0rdr*ƣ5XQQQ~G=9  A1+ߕ,ЀJK@ب{4exSe9V 9ً Ja/|jR=0| \n4/}c%)722p]ZC"V֬Jn/@=XL&w˽.LƏb3$eZ(D9&}hۅx꫼J6t~ V bZH _t[4VwvM?M|Rձ>y[/6`9p1Twbbve-,̀\l05j„ G5k!lyyyܿE| (ce7#!Z0u)!!!++=>rVJK)@: TLm)%ZCIcU\\l2BBBΑ@V'cgqvLs (9A⠱?ZZZWWWUVVן={ǵs4QhAa!'`T &Ϗr{] @yy9!ŋ\2S@HFx@5}4 v -$$:&p P6KJJ֮][o5556vP(&PEH=<<|hc! 4 f} 0?~ӟV\lӧ6C%0J &vi4Ji%!Jtu$rhC GQ$HiU4% $/ ^LBBG=(ApA8tm0%@ BzHsϿ{d: B0;3B"("d4  BB-Qs]Riw>}ț @-H0S)WΦTK+_U(V@kO@]_= @|SLI;7EFB& h)}{>FM;M' 7h:(mƊqƹOS ! @+褧dbe' !V+v X TP3Rs۫hiiX,zjkk~rM@oKִ-;'*MkkB444GGGwMPq R,#ۯ}tAdZ↫k+Yv~D)%Z)))ٳ_II LXŔy/e`S6ƪnpܹQ]Gt>NV Ү|O?oݻ/ҥKn]m}J~umqXemEgЊ<&<|V;/v!Z<im6uʦF{_XWR U,$&2''֭^vɽc~';;>000&&fӦ/ =\6V d8~p8s>ՅZWa k;&jh;9Zl Rʞj- WUUSNjkk/_lX 5MnXV&)UUUmmm|4VrIyyn涵Y,/jUۭV+9aR^^` ;::***Q !3c:۷ؿ?WlٲżE~Ẻ:kUvvŋWXnٲ%22r͚5Aw:֭{W%v*33sҥ=|ܹo޼Yz+l/oދٴioeNs=v'NhVJMM_º&Nxdʔ)|MMMo}>LcW`!{5LK,ُEBRSS;~ ==}˖-kmmp-[L0!99oau׭[ws疔0[#466_@R%,{X<̶m[NVܡCm6[VV+tFC?g̘1NbgϞݹs-ZĶo߾{gÆ O<4J\g=<---55500&466DDD\|P{祗^}Qñ~=z,Y^;Ξ1ck/]h7͘1#33.22?O^^ԩSgϞ={'|矟6mnvlaÆEGGN0aذaV5>>~رݺu+++233sss?l􀀀>}XBCC+Wܹܹs'MDyx ::W^۴ .;Ʈ]nt8ÇOLL*--;vƍ 6gΜ۷mdQQQ#F-,,OLLܴiҥKNx⪪wrK^Ξ=kX95hР޽{'%%;wn@@ljjJLLLIIkf̘QSSp8ڏ?ʀOp{kҤIǏg/5Nŋo}ݬ>y1c y$o%hQQQsmv5״2 555W\y_uәe˖j͡C3~cǎQJ/]e˖_&MB6xsssuuuJJʳ>_@)u8׿l6`y 0?dyyy… ###F6(V۶mc֯_7))))))/?x5\s뭷&''k˗?111.]666677b۫m/777V*}{7n8a„naƌ'xbO<+innnllr矦Äa 6TUU Yw}׫Wz^_4i"=:f̘xw5&N|r-X@i.1;::7n8yoٲEϞJ~}|a^^vv6_8=G|!9rHzzzSSzw&%%㑔+Ȱ|b &AݷoݻKKK2(~GV?nooOJJ5kˠԈ.[YÆov׮]=zo 0p 9R裏#""ׯ_ˠF~d[:f-/?*}!ga.\8qbBBByy9?L2\(ށ&N0`)S+_ePQ> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 383>> stream 8c`0b ul;7c B*fXm%1 `;$k՝5e{)80<.4ܦAx@T߅ oWlK s@R6bAW1猞Jц TA  ~I0SUsSĤ H`ѿ 8${8x|Vt.̹`,{&Gҏd0֜3@r) ufLdDa?`cB׀T@I?KO(@3DaCL CB?вYu$I "Y _p+eapraS#pV VDI ltׯ4%|@C( # endstream endobj 451 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /SMask 450 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om_x \ endstream endobj 452 0 obj << /Type /Annot /Subtype /Link /A 453 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 364.1100 147.7500 476.6100 ] >> endobj 453 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coveragedeaths20.png) >> endobj 454 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 455 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 454 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 15913>> stream x}y\Gp) "'Wbb4j6k6&1J6jI5! DE#[/ef~(g4y~[O=,pF󄄄,[,''o6mp#/q g&i(k֬y=<<gϞ& DxBY$&&rmcc3rH___GGI&){3p <ϣ DPB\4+aÆy{{zzzzxx1bĈ ,xs-&#GVUU^LJE?Ą#BACCի&aACJbz `L3@JO8$o)%3I(\/8" "汅PMRL8R^J*\p¼UJ:JBfdR{{{7oܶmZjLLwAD&@Hʋ/~:.f{HC"z>{ׯ_y~Ν7o$EBJ<,ceee%%%rJWWWRRA !! KII9w\JJ ^x!mL&@:u9&&&999..R灠h~CY/^ ѣ:::fϞ#,A:?JxqT@K/ Æ svvFK{;\<)(&1 XCVϚ51+Ư7o655m޼Y(aV9rdD%f42w-**jii 5fB)(N ϟpss n(\B)O<wys3 ĉm' qג A藞۶m_kl_yZ#P#Jtp AA(0+WV{{{K2PTTRvvv8PJZi/%fcjȬxq-@2foKԌXt"l^4rŊ^^^(ZF)C' `0L(yLJꫯ&$$~C"aD:*ٔTs8TCƗo1pEf¾8wuuUUU}ľ.QDaMb fXfb˪Gr(B*Jaccj0PQvv޽{j](DmJFhɾb! $NJJ 'O$$a $qUھ};w <<ώ|R!B ֥666ݻ ëz{{KJJ5gbR(nlE ;{lEEŋ.%$3gx !q Vq܅ "##KJJ.^XSSR#K@1 ERP{'0 !!!#FP>>>K" B f'm=c3fhjjzG/˄둂y~„  XxqssҥK`lؖ!%`/4hJ EVnϘ1D6bюTꂶ;zF#ZH&» 23gz8 PI&9rUBiL~P^UdhIG8:YI(绻t:ˡsEK{h *3 mR^Zą )-n҆˰cD !Cak֭{7I'A4QEA őUg&12ʂA)ׯ_~z],Z`qdz3X.T~X 9":x/øe'$a=@h1>АS"1!1 &dۙ[H4n\H%RM~]~8w„ D-&aS֜<}[ cfEP \***N< 555'NBfD^#?=LڒgΜ)++ݲC/D (C.~fPw^Juĉz77 8;FFFZިQ8s͛m)=o޼ww1,,m+#~CC"͜YӃTl~q1Ez86&G}w "00`0<555##> ̴gee 0`رqpa]f8PL;wUVUWWϟ?_QK֌P3y#/P"cG^^oѣKOwc="J*`BmYE\p! c!"Kt@ Ə^H5!JY(ys%d`L+(*g"$&B LK{qRPL9(>$8se⚨NGZD[!?a 'ުfB P- L! 7 ŌV2P>hĉT Cf<#FKjF xC^]ZP4LaS#EMy(?Çn s긁"ƞ7~z &bkqd-|ס ngdd|mmmqqq}FQpD L jW_}uYiQ\d .9=/i(&mݺ5##e֭OtR.' m!}ԩ* i|wMLLlllLJJ:q$ʠLMahlLwWUU8ta1x,:{lmmÇ+++###Qtt4j莌DH(+B;n8^qvv2es='B8VTSV!㸞77aÆ 0qܸq'x;9f8'Qk+WD >-JL fŔ"~;::8Yp3}9,_,].ehB(_,RTƸ8;I(P-5 4a41/Bxrt:][ZZj5=!1׉[Jٙzj#b')|7LH.EBŋnT)$,,IJl: ?,))GGp&0E_C&TН$&TcׯpfCB)j/^R!.ތ%r6OmIANHi zzzzzzpR HJJRTt癭(>kJdƏIf"f9ԁo4zk@Fyyy?CwwwQQQxx8q3P_kO"&T~ڵ(^օL4yL\ )~s@/޽qw}օ2RQ\^*PFl 臭g^,Ydgg3 Wƒ(Vzzz=l2OOXF㏃~D,' ~ș䌏/,,lhhX|yllUttt``ٳyùYPٯgGc@F,9s^ bܹ< mfYb`Jegg7|kkkXtippT"'A33ՇU:Wcmmp‘#G*J}YC 8QLT;Ψxg9{>}:hF͜ /bo' _& (QF:,, .E"-4)dffFDڿxK2/1ٷysVgfy0wrvСЯ,G6;Y:tCee9s[[[\Y̫Ցfq@`GSD8~|-VP;$/kÉ;;;Gb=zܯ_?rY.5 ly G[CS,WDEY$!9.yAYӂhDKpK !Ydf3w#)ه &PR6dK& N,mK$QDu1x]9,qZL3#.f33ܹs<ϧO,iGC1LKDwzQGH ӑR) /_!8n޽/_>x`bb"TWW\Ä#+4}ˉ*r#ó |*K|J$''ڵn߾}ƃ r&"?iyᙒk[Έuх]]]C-,,llltuu " p=>n f@E}"Z.--C& OskGBC8_4H555Sno``e垾 3q...%M555 OmR''' 2Iyn(Z$Uyyo[oqN,[L8%\˔ Γ3&LbwO?Wm8$aoA[[!3C2q"Ʒ B ]?~y;?QE}CX'N(t` ]QQQut?2cLZQ iZybŰ_͈X@!߿o -D&;}T*դI ƶd)EV#RN<ǧ]%Z X+/[z{6T*H.gJ(@7M`(~2&$|5MHNNNMn{twN4KJY___RR2o< S(!!'WSMqkXPa#GQ!;5nZ ݒL^y< ٵO7NaGduT*L֖xt00=FA<#T8`#uC:8Ƅa0D冁:fׯ~ DRXGs:S⼼qO$Vmodz6 TFb5B2)ZfLaKGh f=~0lCC}ڋ6h1+)P\*%[,X't-"bGޞePf*Ww?,؂ĎyZuss^p!{T;khQr2 \j ڬ[ Jb3RbC,X=Sk }‘IHeL܂ *.RJv\} a655W)rk2'E7UUg _]pWUU iii)|aF(T(pgܽ!)#""**BhOj`疖lOAb!qoU{mmm mmm_~qǿa7ٯ.-$r7swݪ*G[u<l`#&lAEׯ_7o^NNN]]ݴi^xW_}Ux+@|ֲΕ~ OX$;d!nBʊP.#$A/l z{{DdbuI866h)ӢPC1iAoZGP T77quN` !$a:)(%ʛ7o>o3fLyy m81p /yyyG~'{zzg͚EC԰b677gee7nO>dAA%K8*x<&UX% H4ӟx1Jg(=](d PDt5}Pa6mD9^TPx* E^= @IuJqgMc(?# gSq=1_$`JF WnR39P dfYa9_epp492& 0 RΌO (>wm۶ et)P]jwBXY N&y(]2]R,Y +M) @lDP2MHA{?ÒCI2SR899i4̔Cte^(e tTAyǻtfOsabбC Ij|Miiɳv,R0`СMMMeϞ='N9uٳ_>p@CapA̞ӊ,EО={:::ƍk׮qqqZv…xDÁS~ʕ+UUU=ܮ]z1cN>0}t9X-xe"ٳgsWSS>n8j O?M"D1%$e(**rppT(AAA={6ϜsDCRPۛl2V>x!C̚5i)\0rFU^^aÆ4]3=qg-͞BLsJ1H1K{ldKB(} 8ؙiGQQYY>ӓ^6x]riK'q68*%yjrC-:KZfxdvvvcǎqA <@9O^"cKHA\*YEх 㟳3hv:DIZXS(D¾ 6΃sMwN~ԤѨdqtsD ׯ4e(eNNԩSMbK%K-ڔ f `o]\ `~d[91?\pass >oO,+?S^zk֬q\q|c_a0 ?| @)\]]z{{N+**N<|MMMDDp3HJ/JQ#ޜ8O>LL.]D"*---۷o>}1_vg/ Yptt 9r$x5kVUUFquuԡmGLjF~D~} A=dhBO<ή g&I٢ NSVTTttt\>cٲe...톴HAxܔxsz׮Օe # sf _vQ_Ο??bĈL()ap[?^|9-#<8q ׯ_Xf g@%r@yOώ͛_ IS8x(2p :ejNn_.7=2Ez}ϱ:y'suwi%夓c?gpBAA9{옘Ϗg:WĽ{Ux7azd^1萩#|LeIN;&!*SN{u)=5XA+o]z2'ecYx̞LV6>BPP:ӖEL8@x-Be@brPq<9t@)NJq()yb C@ѯ_=J.#afHdBxޤ2J<+5=PI~LtaYd@/G_*FV,#H9.&T{c0/sAn' vx9J꯸ۦ)q͝;wРAh޼yǥΘ1XDLA_qV&*))imm *//Sn^nyU%( 1e)~{(66vܹyyy#F)1Ϥި/3:Ғ˗/ 9q@RT`︟FLAۅp9;k׮m۶544|g׮]ҏկڽؑr` `עYGݹsg[[ۻkE@p։[f) ]+Zj0:;;[[[{{{#TtoqzQxgCqkO3zTk-H XE/jogGydݺuz?8j4dw$,<rkDt8iDDd(**rq0Q"1&sã`gs4nԹ3AAA|r;`om=3}K .'vj4L;|kBTRP>W^{)ݗ4+zRtPDf {;M¬?dvuut:T#?"c;KńgKe4ɓ'[YYǗpa1~#cCC߸{ t nϞ}2y+ 2} ,.PqH8N$%;k֭ trrG/⁤T&4@5bKN&#7ԜfBA)ɀ2qgLv9r˅X4ek$*sTǕ "!!!66vҥ GZ S!?:TKS ,[='\h3 qH`nw2Р ;K%3]2# :ywq]w궃'O9s)S/^qkkk'LP\\' `/[D}]ٞv}}}{{O^^z9dWxw.DvWVV*  3vv-Cf'%վ\Ȁ^ś؜5AT*oٱcGAAAMMMTTv38{O Dvo|⃝%bk5-YI/ -,, h71[HLo+A&֒E< q0ܯj@ƃQJT&4b:Qg'Lpg *c3HtFZS&.# PNJ5tPV{}E@8!ZvuumT5}a MUUU666UUUbIs px)BSۛ7oرҥKW\KKKNuZZRo*E1 Ң\\e;Ռǒߙcǎof:+--  Fmca!/Ji3g@b"σ=NƬ,GG7|s<[o8`LHg8fdvҵ=S\\|1SU\w7W:@jKFXPYYʡ\)VhhFY~ѣGlbgggzIΟKYYY=S<Ͽ߳gOgg'5O ߷o_HHȨQ~^z?x3\ROַOtzyy quFR'܉'ucccww7yRSSR5۫Rx񭭭GccVK I?wOա'***j*ݻ]]]B6^|ss3΃N===߸qCR\\n u/_CUUU͝;o}ǎWF*І \8E#"8ҥK b?zYqqqqvvvyyyicǎmmm-++۲e zS;wbbbfΜpqT.<<Ν;˗/Bb$$$,]4!!FKXc۷o;OF?HHH5 oF[qW^tyyy1z;wMַΎ=sڵkѱFFFnذ:/&-**tZfMFF*OIIEi42''rᡟ?𩧞zW_z%T#"" ~_h@AAE>O>>#wYhQnn?ϛ7oɒ%K,y뭷6n8cǺ:::>SmmmΝt~~~3gkkk 8p`mmYrsst:777;;t;;Ç3 0k֬{9::s8nӦM7n|]]]MϯcǎؿEEœO>9x`^?a___(??e˖̙3YB?诋ĉ[[[}}}=oΛ7/===44駟4hO<1tlJ2f̘aÆ C{{ottԩS-ZܬOO?Ś3gQyFFFhh(i0BCCϜ9/oCuN81mڴcj4Ϝ9w^t/mmm111.]6moƛm۶N8? fdd۷o$666==}ʕy+&&&=='((ԩS5eʔ[nZ>SNBl?|QQp޽۷o߾`0455=cU 6$ی3RSSy/--̙C~A;::}]V{ر_ <^ W^bŨQ;TX\\/>Frh442Rg"Xhllvڴi^~対J@j;w$?j*bFEE\2&&FJLZu1ֶط.2:/$''߹sg_:?; `JEq.\4hPuuO?pP"^; 63?cwwŋG~()6`0Hm2{SN?~Ȑ!%%%ǏG`xu()XKK?PPPaoopPRnv r ҥK^w^> rD΂ 󃃃}||Qrt2 ABQF͝;XQ=LE&3Vsss\\ܨQ{9zၠh獎= endstream endobj 456 0 obj << /Type /XObject /Subtype /Image /Width 64 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 64 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 446>> stream 8SgBQ\CCzf2CIafzLCd$WL2$Ir:sʵY9~|.Bda-\*_v|%OJ45+rV;2w,pfzYbܣ`hPI \d"bQ}RdARˠFIZ'{jlhp%d enڡ۝ꦿ[:B5F[0f2屟G~cU~H;)A\ڨŀ u[ւ2 gw*;slFK"]$L)Mrbo!G[ Y!>Sê_> IJ Tr ~G]*F YrVk͔$-Р^Ŀ@IyUeR[#D? endstream endobj 457 0 obj << /Type /XObject /Subtype /Image /Width 64 /Height 18 /SMask 456 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 64 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om   endstream endobj 458 0 obj << /Type /Annot /Subtype /Link /A 459 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 154.6650 147.7500 267.1650 ] >> endobj 459 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coveragehospitalizations20.png) >> endobj 460 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 461 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 460 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 15913>> stream x}y\Gȡ(F<AE+Fc$?͹dͽF(jNC0$**1x((\ r_!7 LS]U3}o=ST]j_߽{d2LK.]vmzz;~#G< #gL6'""bҥo;vƍ }ݳg8"pf"0>>Æ 6lܹs6A*:~`# (A3i3=@=B_|ʹ4wyuQ_t+#.B)ZZZ:::ݻJJJ~駋/vuu]|ѣ qe[ZwUFFF޾}OMMs1#d It'N455ǧ$&&@\\Z6y(^zܹsп9rdXXXGGnj3=HB /N[JheO>ށNNNcǎussCK{;\<)(&1 <>>>f靝̥ Uleee]~Jys5Zf E)# D]aF Áe xU(P JSÙ3gBBB<==9,C۲ ׃PʺǏoذ6yk(?߷Jhk˄ KOm۶=y(‘G_p{ŋkz(A*zHA);;;  _NWY8PM1pdϝ[<P7lX [@RꅻcaW }@E{/J裏hIANlff-01i(Eff /poH$l\HGe2=:jj1bl|y( 'ZT)yh[l;ׯ_WWWee%[싞B <eqɘaNL<i[ E2\VE=CRP {{{Ʉnݺwޮ.Fk.J>QvDZbXH`B!/_e4?EHI!#$ī};w@TTTUUu|)>BKA)rrrݻwgggGEEUVV1kĤQLs#hA9ty銊s@IIy$3gx !q VqٳgbbbJJJΝ;W]] W#K@1 ERP tvv><>>>&)""bذa& `S2~sB(줍Q L:B<  3J#qhѢ%Ktuudf-CJTií_ J9p@Zaĺj*ԩS{zz@Dl3!H.hgK/|aa$LnBy(AML6 Μ9דġ8lG_H*PL0СCt"Z'.hLf򺖯"EKB?J@qqqǡ|0}'"JhnSHJAYJ(7$/b$eeeSNEsҥܮ.h1 儠R6H{쉍jᩩFQ#1,P{;sBl?㧟~:h \C JQVq/\뻻K{XBwb8ˉ\qƍ=F1 `߸F _x^ yw֬Y9994yӥP91p&2---""^C?S=Odʢr$B<}vuuEEE}TOk)#"=i("ă -!#J5DNM|5bd& Rnܸqƍ44ɱdgg(\4"orDt5bS 'øe'$aChӐS"1!1 &dۙH4nZH%RM~oʜ]?kܸqD-&aMz~F?W(J_˛;-::.V;::<<JP(&i…+#>O|fT?zh///___779s80̉.3L(&Baa;w4ͪU̙#-CBkF(ҙ׼ѧ~Z(#p//\Qĥ;ñ^i0lAΞ=B?}E(%6C}RMWlJi +%hlbJJAę3ɠIEuFjf1Se$aN9T2qMT#f-"I\Э0BoU3p(bF+(|0~_T!3MPN%5#|!f.x-y(f`k0̩䑇ݦ7ɌR"vPT ggg6z}aaaTTq3P_kO"#M*rJllhEB&<&oEyQQq| ZH%GRm J77z`+ٳh4ŋ_|'^V =Aq(:FFFvww;K.MHHj .+F!XN\摳șTPPP__lٲ;;3f6s >ѤRUTTKR5JkxK$K,u={^!V OejCBOCَlu2I9dgggJ5sLf֋b;MU\z%Q~]Խz=!xP`()GEQ/ZL6<I#`ha /ʀ(+𾃄"$eU455-[8(kZp@-YbzE /j0#q>}n %eCd0 MMMѶDETcGޕw4s8BjfCɴnׅv@Z9%f(3 uuuEL7oDǏ?8pu)=oh|Aqd䓚DVUSS#ܼy=]`F4*ɗ/ggpj…3f -$/[lȐ!&Lw ;ZyQ>F&mƓy -@YPPܻwo{{{```zzzvvOX/7Wi 9x"a*W: d")ǎ&0[Dr^\T0a v%(h[oY2a]]]IIٳ6IYJV"nʯq٦8@) f0#e5vF%1$' 8%Y0:{_-//G_~&##q|0v1"#&Z`6 q\Jo6{BɜHb&0&O#F(++۽{,j]lI+Hϟed"~ZMyZ۞tZr7tv#Ϳl ȐR1GDE⃝Y rҫ6@Twٶmۖ-[lَa,d`F.J2fR# Zo޼rN=tHaT4n8+kjj^{mQNyG'%\j[nݺu(Y$W7"U.`ai5Y?pwo)V hER=> ,9:t1y,CxS_lSPIBҫ Acl I OĚIwָOsKf V%#9kBc0SJ9z,때ʵ&OB0wgT5N?3, cg]$VVuJn΢TIܓaSRJJӦL5`9*-6zєp ,}\XeU\9,]]!w@.bʑ$4`ݻY]zH%M+j`QcaåRill,//2eJsssqqqhh(5,3iNKP2]]TVVj4߼yϏ) (e!5lnƗ҂Haaa|IĀuYC ~s)W`"H*2w5yB_~YZZo>}:77wӦMUUUf>ɷg{|j^[5ѾB|`>>ܵkWlll]]ݶm`u--YwCqD*g .R +vttzt*ӧW\5tPooa  EEʪh׊ dЮ*..׷ ?ع9;9@ 1tqkU&^__֦j]]]//fK_ZZZ8+**9| ޟ4mbGL؂祋fϞ}ɓ'_%q:ֹ/b#V)I8C/q+ 0LvvvrBF4o#>MP ROO;1OlrfČ!-a='xV2- :sm B)h>|PYbn1hy*EFl⾡tzk :RRRR ///22LH 秫0AlnXBt.U)E TWW;w0&uOP; r-[z{{={v ހ@3 }1/ }'''gћ6m8qɓ'GETфa #agt_ʙ ]766Ɯ<':;;}||f*ExD J.8NRTׯ/\0##cԨQ+B3 -oxNTܑ#G>MMMAAAӧO'Ij~1p nj3`Gy$??Ş}A<Rz*l$O%3.ANF( :iX(0qDN* <yVT"Jd:%IK߃RиMrApGT|y XU[(23~288ϊmKBTcHQg'BryO?5kֶmۄ2Ɣ@.5D!,êT'd<.Hl[./B)/^ 6ym|YNm&ĠaIA! $tN/B)\]]ZpfJAA CNNΏ? &XJd_~Q^?K}2n.LL\:vHA1i߾}*J}WRl6Z'/̑mP2ٳG׏?>>>ĉ3fHKK0`zP"\)K@gϞ1cڵkΜ9/rbbN7o4ap (x[*++z]vQF&3f8}̘1&IӅ)L ׷SP 4hƌo|#枞˗//]Tӵ4hӧO DZbv ib@oڴ)>>M aaiOY vӜR R̼Ҟ8(PJj_B('vdڢac~UtttTd-b 򬐃7O[: Q-S[ h;Yzz'D %#tttTTGqA <@9O^"So_`vgy S$25|m`>{lRSn]gh>@lU(D¾ 6΃sMwյ7[. :Tx|'0kfnӔ Woߞ4i],ۮ¿$<"@a&hU6ZOcBkJ9o޼&www|XN3Uh +VL*4[+P 7o VTT?~h`g"UrK-9¯baoNLLyɓt+Y.ܥ|A$|llpL&E|Ge d2Oػwӧ333RfRE777OOO0rH z0%"7ӴD  E:~ĉΎ%%%7x`&80I塔+V~[XtiOO;eD^Mg%8ڵ ]@aa-a6F BdRhU_̙3Æ 4hȄEPʴ4kׂx TPPsvRR!51)b?>X`0A{r\5I/s[^"jo|9ЩqN˵Ic3Av1QrثKOX\}n˪?s].:.J _B @L[1xRIyr\4R4PR4&Yܽ{Wٷo߈˗ '&HWf"/5]Tb!q(aDQ0&TfNX".R`;q?tw6uT`; =d 帀6SIŽ4ٞHNj8B*L(OD  q_Kcƌ5kJ]]]aaٳ9zԩSE幹oF^X1\mbVBURRV^^'ܜJ(zVWO ,/CD frvv6l^iT K]VVWXlTbrqح+~UQyzd2>ZD^u}]fS_ԽawZFజ:cHB-,`NI~XN0k]]N} HqQ҈fC Ik/7ԜfB%:BR^f4 0ڲ݄v^cG_,afw (N6-88xѢEǵԌ7 Po-˧X>cd!4,2d]Bwkյi"\!^Q\N`gq JR(ƍK/MQEń3\q֭TgggR _}Վ;󫫫cccp/DG޲<2iQe㸝;wn޼믿,{0y0-g}aÆ2bHB'Y^KYJ8]+ѱ!:֭[vvv惝{%L< 9,vM0Z㪪93r BĮB﵄2⃰ZeeS{{ǽ) !ֈ6Edi^Z$R PΝ;/"Rݻn`7o#$ToJc>ުt>$1]8ph4gjSR6n)ѧ$#GN֙3g.^Hʘyb8t{y)JYZZzΝ]vJ%Z`$}%햯dK.: xdm޶yNFÃǐP59}F|[0698e~s8//jUnS,,IYki~I4OrS(h@шmptFBKFq0tPfZ]{%@ , GnhYuCY{i3WV~$_Ml@I)Ðx9l10F7pP`އj_8ٴcV+YJtr6$(U@O؋ҁ$qpx!+KTo_;*x1M=[7h*on &uB}ʘ .-LgZZZ**HeeڎybGp_QC٩V ~+R! F}>>츓^3Dh4zãvbRXf܍sR_mo?E5%E*+++++* sp].ܙXEK)Ʋ.D$O믯_cǎ_x/--8.in~8PJ >9Y!>Ľ)1/>r$; ;:SRR"""vQPPW_m߾`0曥…zwph((o"?0yr2σt%% ...ʜ9s|W_}544YbOrb=vXJ m'N(YWnJl.:Td,ݰaVݸqÇl8rHA-__~trrڳgOgg'zO ?ܷo_DDĈ#~gy %w޵ZmyyZnkk+++߬onn&ގ7 uuu uuVV7܉7uCC^7/juyyV8{zzj5/~5hhhtxd8Z@:NVuuu Uz}[[/~} AT[[k0:N=Q.| !^g}… h\ۖ-[T*sݺu=\KK ~?Ƈ*??Æ v  w^B؛L?n+o6|S;vzw:͛V:x о}<==>뇩Yo߿ڵkn ur֬Yx;vXf T6mE)zf qqϟW(7nQybbիWsssU*=l˖-藪ܹ?mڴGQQQwYlYee%… K,p?j?@GNÒɓ'[.\1Lh+ҥK!77?DP.]s玝ɓo]ߺu+!!ԩS֭C@RRʕ+cbb6m_c𯅅k׮D婩NNN555:V[VVZ]]]^^./_^xgPh>'Oxkm6Ǘ3gΠ p7o^ff}6n܈JWXO?<v TWW q%Zi+W|G&MՅV^]XX755ܽ{w۷o7L%%%񍍍 ,@!<==NzUKKKۙ3g wqqqoN;rȯJGFcbb~k0p5k<#FoPaqqO?zA!Z-fxokk>y$)::Zj໻F#^> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 383>> stream 8c`0b ul;7c B*fXm%1 `;$k՝5e{)80<.4ܦAx@T߅ oWlK s@R6bAW1猞Jц TA  ~I0SUsSĤ H`ѿ 8${8x|Vt.̹`,{&Gҏd0֜3@r) ufLdDa?`cB׀T@I?KO(@3DaCL CB?вYu$I "Y _p+eapraS#pV VDI ltׯ4%|@C( # endstream endobj 463 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /SMask 462 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om_x \ endstream endobj 464 0 obj << /Type /Annot /Subtype /Link /A 465 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 573.5550 147.7500 686.0550 ] >> endobj 465 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coveragehospitalizations17.png) >> endobj 466 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 467 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 466 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 17224>> stream xyxTEV'$!!aK6(((#*2:DQPGQe\QttdP( lY"$I'ꪺ7:'ܮ{ꭷN:u{aXy晕+W:N9gΜ|0==OLL~衇kJ) HU):RM֙>ϯaaa#G4L{/%1J);`>j%,;ݻw|||ttt\\\lll߾}{ 7hj+:JP(ӿn3!!2cƌCSx~P>S8l?SEϳL㜜G@ɾ/傂vsr U dM&Ӿ}ᥔHk% z |ӂkW5e/Qb%X(ӕ+W.\0yd"A)\pqPBu{>Pʠ2LL61ALң" z:]kPҕ'QvyC{{{eepVJ((Zj 4Ku] e 6bHC)/ e/:e#OW|5{l%1\n oLk?<(L.dNP#F|Wݺu3ʯR=?͊8A rވ!\K=h\c J(sGGG```||H9!!ӓW\aÆ3f;v,-?%~<3R0<'ukժU7x?nܸ 3P2!!C<@@x(շ~[SSe͖zp\hK %00n3E%%%L~x̘1 ̸GNBgucaYh̙3͛7~x ,e'y~hP&M۷?mڴÇp'ЃZJ(see̙3ƬYf͚>|X-e]y=!CBrss5+w)@Tf{+vő<%-eO\ty1UTTlݺuȐ!f B M8A%AH:EGV˾8֒y^S+TC=v % kry~J`%RBN'+:{5kZ[[VX!ȎdW-"3- J(֭s8[n&J{B9o"믿~y֭+--ΫW>X*,x< L~~~ʕ+Ϝ9nݺݞrY3j[nLT֫VڱcGQQў={.\ ?"!i".;@^ ɇMzBݻ 6lؐgϞ˗ʹ1 PJ;);;oniia}[bccNɓ ]{C@Eh);&7|㫫o&dV~SGR:|Yfz뭭1.=CޯeX,/f ,N?nCn"39~'?ĉ.Lx7c(2 &^prR4rȼJ^ZlDSzR_4q( ΐbePʼAʔ4evikaGDl)E:#+C ?!1MyJ`^K(*Pfz$É[_X 4{Pª /J_ESy9$J#G66{w\__߳gz9tZ=D%^x:H9 e-~ ?S=c1[r:חuUb22ػwm'`M}W0$Ͽ_ +{B[^BgN#G3f ''ĉ .LMMS]?-魗J51'Oy)))T_6 3[o #TQ;::<8c [AITTTTPPJzCeff=:++ui/ k2^Nآq7nlll8qbZZ࣡)x¼A >䓷z+"""22mP^ˇ֑R1hll~ɓz)VGa'Nx}q+IHi2IQڋNP $))RzEWOADU2N[M7K{iȹ`+=(SPPPkku>^OZEQېFvɰK(IjaCZ<\JIF wƠ]=(%K,YWA%FjTQP2O#v*++ :T/r oFJ"W~N[@2};d=>zDŽOCA&=;! >(ׯO[+S. ĹO^Pf\WKꪷhz Ʌwn@/NR")XR/A)':s@2B>pr:#'J(0 "D|뒏A_RP& !h֭._yf}y~asΥؾ}{AA{]2-FP>e|8Vz;gVfү_͛7WTTp Xӽ 6([:uUjkk{yȑ߫VjnpzN5#L;vp˨QҲ,XvA]}Nzc~C Vg1_^xbbb,KssstttYYY꫐W0yT*k:wn6+++-_luڢEd133orJ}}9sϟc~>>>J #3yGe^B]XRH%Bubx?h+^@7P&M@A86fe9D71z(/'Bm(ܹ=FΡeD> + 1)y9*S8q]vmmmB*(YJ9}II gݷo/+]~K/.?zѣ}ٶ͛7%%%ɗB36"e#@Brrr?555%%%}7la0d<`A\b8q?\PPЯ_m۶B%_y>}d2;tΜ9Og>iʲ9s&44t={޽iӴFyr J{ N6MG;%c~:A㫯?҄ځF?%"^ 3_mm-{'&PB my %޽;99gϞBu^K(D@>@ O^5 d;rP(3T1xI5<3 d˅^VW0z7jD9P&~Hx PeX.'")ȭ_pxުVBix(%I! C)W+(/}h' M9`Zuk cq?yAJS3šcYyC9 g322y՚o666(J8ma1k}w}wǎZ|,3_H=wf6%\ JhK(m@^B,KUUUjjAფ қ*GJDYW]BDrauNu +L---YYYC(X Tjt@*RvC 1JC0Rb*ϥA/6P .-8afu(%.k٬VR~҂Bsss[[4^sCC<~BYԩSGK=큧|Vs(,jUy{[1-]$蒳>of8_cSEwo}7x`=&P)9%Ç[,j@8䒫 }42oc=fy&$$$ K&*홈)WC{搐6>|ZZڃ>X\\|[o.=c#TA )ǎ+((Xp_~ɾ/̿D6v6$?r[*zμy?dȏB[wU2ƬPݻWVV[^p7nÆ cH\7fRA^G^jUGGǰa6m4gΜ8kPRdA K>Ⱦ}rrr*++ΝsXOC`i!A/DySh^{l4iRttnL&qE.1DR4# 'N5jT@@i|}}͇o@V/ ӧO߿bb̾svR,zPʎXCi.++ ȸ{!<q^:TyŗΧ~MJJM&5^+ 0`G}ĎWZE)ݽ{wJ(bDC.\PTT4g 8+} %2`(]C :<ˠo}4+$$%+5 M>t_tfᦛ5ݛE+Q֮];w^z9>F.C1'<A(ٳAsrr~5k455%&&9s;,--jN٦( !dժU FZn7 q̙p80RSC\;޺^c:7p\ LY"'P=t/}ѹS00d҃#AH´b?)L'Nloo?{^g2Ge=&6B:˧e ֩SfsTTTZZ̙3vFdeQʔsСvKII9sLҪ1]?S5Yr;лw[_pܵ('2o/%T]l4pTBࣄr'8:Q\~\ ِ544/Wfs"㊱tQE37,,xΝ5Ĵ2<τc!y"\.©\GKK1NIJm)|{O5]Qce%3g̘1cٲeu~lH倠H_zVVʇ~H׷SeÇ%/sTUUK_%׿cqFv๱GFWYeyeӵ£ՆPJuBwFjXΟ?ꫯ.[̻uB:[+ ![Q.:T;xG8uj;52rG2lej,oq~S)"//Nl@rw ERf4:jB닐N+P $P'V!c~10UFI3`e89N x$Sm(/3F=ihwc4FOWU8d%*JPPB]Ƽz]ojNEi&{|@L'kVgSHO=!\$x+)]ܘ*m v T;թ v}kLtKMƧE>]ݤCUNȟU]S2!_7FLAOћA`SB\c)3ܨI0MuuS!uuu[۾ZE" Q[;T QJJJ233:uEY%W>>RǢ+wzVyV8 iAZ_ͦ~|OeC('EAwфSJ5A) ,<+@b(e OT$tȑ#.\j*wiYg@Oח(gϞpȑk.ySC .N۷Ϝ9U/QB)]ꪠ:7v$,,G^lYyyy޽w]XX~;o@V`R_뛙9x'xdԨQ۶m4hPGӆA}Q*q ;v8W߶*J tD,t~9sӧ TXXx]w =⪝KwdqqqVVo喚뮻N #ް ~)x555gΜ2dHnnٳgixM/cAD=QCBc&l'o4_%Ta?&uYs-FX8-{PWNAZTx*T* ҫ_ =(Ncl{P&2B0H(3!bBP=(G 2 @ +OZ6GՑx1 P<E97I`n ߀2[SLyWdUכdYaѥTwJn:3qHPٳg}5s./0mЄ 98PJ1:d<%9""&8qb…999NZ`aCyV>sx('O,));wMBCCaGazPߝ}mE0 ^`1{o޼yџ|-ܢGހlc5vj]Oh6!@1vTshhh^իGe˖o?~xn؃ŒB?甡RoyYzuss!CVX1mڴ{,55m|B='h`ZC8{lIIɽ޻b 1hРm۶%''_{zWң;~1!hdb^n]=AѣG䴷'$$$'';v֬Y.R"k>|b6mbԩ]w0'ѷo_y7N6f[zgwv @u2PPhw}ʕxGĉ-Zp8Ο?/t[hU62^x8ydBHnnKٺw|J҇Dس Z~=ڵߵqeRC@ +ajnn...>x𠖃sM<¯fe3xe6+PP B*ՔN DQf3LAAA)~$P :|e(aZȳJVXiPYR? *wm  0&DPs?عJ{y`>}zMMMTTyWUU}^oIIx, f*ߖ}!)<^҅Z+@A#(4UKv  }jZ6f4 SN1 eddq/_޷o_Y>}@ Fܹs7tۃQӎ||Y棩<[ڛfvb~gs޽s 0SG@Tt&tZVfү_͛7o;X- Wj`ժU={ܸqA)^E“~8r!VAmNz]cc@q! * h{r񴴴 l۶ws!F~}_g8m%6G3ʙgP1vip 9,,,99ZLLbinnPk:s|\[V36yr$%OHwн{wl5dȐn>5EM"8\___.`у{b7%؆SN Ϗ=x䀀::FPJH;p19< :p/EEE/_nnn?>{N6gGX ,'I?.b v Jqeu@)_0^i4@Z#_ RtX !.VGJ2<tgzMAv$!N!az3:)S:&U'%&YƊYn ń-s2 J͔v^ 7uHIc* AUÙ?Pf3_-[v5d7~,DH%@`%!j$_Lki!iKI9((hɷ~c uFhLԤ(T²'HOAw{kNJ'|HIEd2bq]J Gp^_WNr{xNX~*fI@h&$H"#.7w9 AN Xgp YI P z \6؀(0P_ IS'6n]Jw!CL2%<<͝:u*!رcǏZ@$h8@0 mނ p(/+H~~~}}q ^:Li10P *҆.yM $22"L B(ON;w2eJHHHVVV߾}ݽQZ !@άŮ10q"!!  }:Y”?h|ɹs6o޼vZ(E؁BJO=Sa "h 㧜+VxW+++|ͣGX"I1@!`#J:Z$i"IJk?M/_nZ}K.*rz@`ʔ錛jt=LZ87+a'ONgKKKMMM}}OUUn\%fBzi@_BLDAZ+c(pz(KHf/yCLi ]1^{hE G v;{t aG-T1XEs5B f617|yʍ7C9(`(pRZFJ4-m (37ٳg͍ڳtBgD(^MLh3+A ̸qO;w.:/c}4VB2`p<+u @f_fΜٻwoM敠< }.5RXwPjh.#(US Q @xOSd)=UoeG ©/`9V&F^ ,) +{uIȘ2R!|n춴:G;؎ P% _zPFH7J[-NU 8+sQQQ{{;{8S9^`R !~@,`:Y(>}:#[[=M(-#U32Z[n+o )ןēUp=`" reK#*0rdr*ƣ5XQQQ~G=9  A1+ߕ,ЀJK@ب{4exSe9V 9ً Ja/|jR=0| \n4/}c%)722p]ZC"V֬Jn/@=XL&w˽.LƏb3$eZ(D9&}hۅx꫼J6t~ V bZH _t[4VwvM?M|Rձ>y[/6`9p1Twbbve-,̀\l05j„ G5k!lyyyܿE| (ce7#!Z0u)!!!++=>rVJK)@: TLm)%ZCIcU\\l2BBBΑ@V'cgqvLs (9A⠱?ZZZWWWUVVן={ǵs4QhAa!'`T &Ϗr{] @yy9!ŋ\2S@HFx@5}4 v -$$:&p P6KJJ֮][o5556vP(&PEH=<<|hc! 4 f} 0?~ӟV\lӧ6C%0J &vi4Ji%!Jtu$rhC GQ$HiU4% $/ ^LBBG=(ApA8tm0%@ BzHsϿ{d: B0;3B"("d4  BB-Qs]Riw>}ț @-H0S)WΦTK+_U(V@kO@]_= @|SLI;7EFB& h)}{>FM;M' 7h:(mƊqƹOS ! @+褧dbe' !V+v X TP3Rs۫hiiX,zjkk~rM@oKִ-;'*MkkB444GGGwMPq R,#ۯ}tAdZ↫k+Yv~D)%Z)))ٳ_II LXŔy/e`S6ƪnpܹQ]Gt>NV Ү|O?oݻ/ҥKn]m}J~umqXemEgЊ<&<|V;/v!Z<im6uʦF{_XWR U,$&2''֭^vɽc~';;>000&&fӦ/ =\6V d8~p8s>ՅZWa k;&jh;9Zl Rʞj- WUUSNjkk/_lX 5MnXV&)UUUmmm|4VrIyyn涵Y,/jUۭV+9aR^^` ;::***Q !3c:۷ؿ?WlٲżE~Ẻ:kUvvŋWXnٲ%22r͚5Aw:֭{W%v*33sҥ=|ܹo޼Yz+l/oދٴioeNs=v'NhVJMM_º&Nxdʔ)|MMMo}>LcW`!{5LK,ُEBRSS;~ ==}˖-kmmp-[L0!99oau׭[ws疔0[#466_@R%,{X<̶m[NVܡCm6[VV+tFC?g̘1NbgϞݹs-ZĶo߾{gÆ O<4J\g=<---55500&466DDD\|P{祗^}Qñ~=z,Y^;Ξ1ck/]h7͘1#33.22?O^^ԩSgϞ={'|矟6mnvlaÆEGGN0aذaV5>>~رݺu+++233sss?l􀀀>}XBCC+Wܹܹs'MDyx ::W^۴ .;Ʈ]nt8ÇOLL*--;vƍ 6gΜ۷mdQQQ#F-,,OLLܴiҥKNx⪪wrK^Ξ=kX95hР޽{'%%;wn@@ljjJLLLIIkf̘QSSp8ڏ?ʀOp{kҤIǏg/5Nŋo}ݬ>y1c y$o%hQQQsmv5״2 555W\y_uәe˖j͡C3~cǎQJ/]e˖_&MB6xsssuuuJJʳ>_@)u8׿l6`y 0?dyyy… ###F6(V۶mc֯_7))))))/?x5\s뭷&''k˗?111.]666677b۫m/777V*}{7n8a„naƌ'xbO<+innnllr矦Äa 6TUU Yw}׫Wz^_4i"=:f̘xw5&N|r-X@i.1;::7n8yoٲEϞJ~}|a^^vv6_8=G|!9rHzzzSSzw&%%㑔+Ȱ|b &AݷoݻKKK2(~GV?nooOJJ5kˠԈ.[YÆov׮]=zo 0p 9R裏#""ׯ_ˠF~d[:f-/?*}!ga.\8qbBBByy9?L2\(ށ&N0`)S+_ePQ> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 383>> stream 8c`0b ul;7c B*fXm%1 `;$k՝5e{)80<.4ܦAx@T߅ oWlK s@R6bAW1猞Jц TA  ~I0SUsSĤ H`ѿ 8${8x|Vt.̹`,{&Gҏd0֜3@r) ufLdDa?`cB׀T@I?KO(@3DaCL CB?вYu$I "Y _p+eapraS#pV VDI ltׯ4%|@C( # endstream endobj 469 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /SMask 468 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om_x \ endstream endobj 470 0 obj << /Type /Annot /Subtype /Link /A 471 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 364.1100 147.7500 476.6100 ] >> endobj 471 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coveragedeaths20.png) >> endobj 472 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 473 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 472 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 15913>> stream x}y\Gp) "'Wbb4j6k6&1J6jI5! DE#[/ef~(g4y~[O=,pF󄄄,[,''o6mp#/q g&i(k֬y=<<gϞ& DxBY$&&rmcc3rH___GGI&){3p <ϣ DPB\4+aÆy{{zzzzxx1bĈ ,xs-&#GVUU^LJE?Ą#BACCի&aACJbz `L3@JO8$o)%3I(\/8" "汅PMRL8R^J*\p¼UJ:JBfdR{{{7oܶmZjLLwAD&@Hʋ/~:.f{HC"z>{ׯ_y~Ν7o$EBJ<,ceee%%%rJWWWRRA !! KII9w\JJ ^x!mL&@:u9&&&999..R灠h~CY/^ ѣ:::fϞ#,A:?JxqT@K/ Æ svvFK{;\<)(&1 XCVϚ51+Ư7o655m޼Y(aV9rdD%f42w-**jii 5fB)(N ϟpss n(\B)O<wys3 ĉm' qג A藞۶m_kl_yZ#P#Jtp AA(0+WV{{{K2PTTRvvv8PJZi/%fcjȬxq-@2foKԌXt"l^4rŊ^^^(ZF)C' `0L(yLJꫯ&$$~C"aD:*ٔTs8TCƗo1pEf¾8wuuUUU}ľ.QDaMb fXfb˪Gr(B*Jaccj0PQvv޽{j](DmJFhɾb! $NJJ 'O$$a $qUھ};w <<ώ|R!B ֥666ݻ ëz{{KJJ5gbR(nlE ;{lEEŋ.%$3gx !q Vq܅ "##KJJ.^XSSR#K@1 ERP{'0 !!!#FP>>>K" B f'm=c3fhjjzG/˄둂y~„  XxqssҥK`lؖ!%`/4hJ EVnϘ1D6bюTꂶ;zF#ZH&» 23gz8 PI&9rUBiL~P^UdhIG8:YI(绻t:ˡsEK{h *3 mR^Zą )-n҆˰cD !Cak֭{7I'A4QEA őUg&12ʂA)ׯ_~z],Z`qdz3X.T~X 9":x/øe'$a=@h1>АS"1!1 &dۙ[H4n\H%RM~]~8w„ D-&aS֜<}[ cfEP \***N< 555'NBfD^#?=LڒgΜ)++ݲC/D (C.~fPw^Juĉz77 8;FFFZިQ8s͛m)=o޼ww1,,m+#~CC"͜YӃTl~q1Ez86&G}w "00`0<555##> ̴gee 0`رqpa]f8PL;wUVUWWϟ?_QK֌P3y#/P"cG^^oѣKOwc="J*`BmYE\p! c!"Kt@ Ə^H5!JY(ys%d`L+(*g"$&B LK{qRPL9(>$8se⚨NGZD[!?a 'ުfB P- L! 7 ŌV2P>hĉT Cf<#FKjF xC^]ZP4LaS#EMy(?Çn s긁"ƞ7~z &bkqd-|ס ngdd|mmmqqq}FQpD L jW_}uYiQ\d .9=/i(&mݺ5##e֭OtR.' m!}ԩ* i|wMLLlllLJJ:q$ʠLMahlLwWUU8ta1x,:{lmmÇ+++###Qtt4j莌DH(+B;n8^qvv2es='B8VTSV!㸞77aÆ 0qܸq'x;9f8'Qk+WD >-JL fŔ"~;::8Yp3}9,_,].ehB(_,RTƸ8;I(P-5 4a41/Bxrt:][ZZj5=!1׉[Jٙzj#b')|7LH.EBŋnT)$,,IJl: ?,))GGp&0E_C&TН$&TcׯpfCB)j/^R!.ތ%r6OmIANHi zzzzzzpR HJJRTt癭(>kJdƏIf"f9ԁo4zk@Fyyy?CwwwQQQxx8q3P_kO"&T~ڵ(^օL4yL\ )~s@/޽qw}օ2RQ\^*PFl 臭g^,Ydgg3 Wƒ(Vzzz=l2OOXF㏃~D,' ~ș䌏/,,lhhX|yllUttt``ٳyùYPٯgGc@F,9s^ bܹ< mfYb`Jegg7|kkkXtippT"'A33ՇU:Wcmmp‘#G*J}YC 8QLT;Ψxg9{>}:hF͜ /bo' _& (QF:,, .E"-4)dffFDڿxK2/1ٷysVgfy0wrvСЯ,G6;Y:tCee9s[[[\Y̫Ցfq@`GSD8~|-VP;$/kÉ;;;Gb=zܯ_?rY.5 ly G[CS,WDEY$!9.yAYӂhDKpK !Ydf3w#)ه &PR6dK& N,mK$QDu1x]9,qZL3#.f33ܹs<ϧO,iGC1LKDwzQGH ӑR) /_!8n޽/_>x`bb"TWW\Ä#+4}ˉ*r#ó |*K|J$''ڵn߾}ƃ r&"?iyᙒk[Έuх]]]C-,,llltuu " p=>n f@E}"Z.--C& OskGBC8_4H555Sno``e垾 3q...%M555 OmR''' 2Iyn(Z$Uyyo[oqN,[L8%\˔ Γ3&LbwO?Wm8$aoA[[!3C2q"Ʒ B ]?~y;?QE}CX'N(t` ]QQQut?2cLZQ iZybŰ_͈X@!߿o -D&;}T*դI ƶd)EV#RN<ǧ]%Z X+/[z{6T*H.gJ(@7M`(~2&$|5MHNNNMn{twN4KJY___RR2o< S(!!'WSMqkXPa#GQ!;5nZ ݒL^y< ٵO7NaGduT*L֖xt00=FA<#T8`#uC:8Ƅa0D冁:fׯ~ DRXGs:S⼼qO$Vmodz6 TFb5B2)ZfLaKGh f=~0lCC}ڋ6h1+)P\*%[,X't-"bGޞePf*Ww?,؂ĎyZuss^p!{T;khQr2 \j ڬ[ Jb3RbC,X=Sk }‘IHeL܂ *.RJv\} a655W)rk2'E7UUg _]pWUU iii)|aF(T(pgܽ!)#""**BhOj`疖lOAb!qoU{mmm mmm_~qǿa7ٯ.-$r7swݪ*G[u<l`#&lAEׯ_7o^NNN]]ݴi^xW_}Ux+@|ֲΕ~ OX$;d!nBʊP.#$A/l z{{DdbuI866h)ӢPC1iAoZGP T77quN` !$a:)(%ʛ7o>o3fLyy m81p /yyyG~'{zzg͚EC԰b677gee7nO>dAA%K8*x<&UX% H4ӟx1Jg(=](d PDt5}Pa6mD9^TPx* E^= @IuJqgMc(?# gSq=1_$`JF WnR39P dfYa9_epp492& 0 RΌO (>wm۶ et)P]jwBXY N&y(]2]R,Y +M) @lDP2MHA{?ÒCI2SR899i4̔Cte^(e tTAyǻtfOsabбC Ij|Miiɳv,R0`СMMMeϞ='N9uٳ_>p@CapA̞ӊ,EО={:::ƍk׮qqqZv…xDÁS~ʕ+UUU=ܮ]z1cN>0}t9X-xe"ٳgsWSS>n8j O?M"D1%$e(**rppT(AAA={6ϜsDCRPۛl2V>x!C̚5i)\0rFU^^aÆ4]3=qg-͞BLsJ1H1K{ldKB(} 8ؙiGQQYY>ӓ^6x]riK'q68*%yjrC-:KZfxdvvvcǎqA <@9O^"cKHA\*YEх 㟳3hv:DIZXS(D¾ 6΃sMwN~ԤѨdqtsD ׯ4e(eNNԩSMbK%K-ڔ f `o]\ `~d[91?\pass >oO,+?S^zk֬q\q|c_a0 ?| @)\]]z{{N+**N<|MMMDDp3HJ/JQ#ޜ8O>LL.]D"*---۷o>}1_vg/ Yptt 9r$x5kVUUFquuԡmGLjF~D~} A=dhBO<ή g&I٢ NSVTTttt\>cٲe...톴HAxܔxsz׮Օe # sf _vQ_Ο??bĈL()ap[?^|9-#<8q ׯ_Xf g@%r@yOώ͛_ IS8x(2p :ejNn_.7=2Ez}ϱ:y'suwi%夓c?gpBAA9{옘Ϗg:WĽ{Ux7azd^1萩#|LeIN;&!*SN{u)=5XA+o]z2'ecYx̞LV6>BPP:ӖEL8@x-Be@brPq<9t@)NJq()yb C@ѯ_=J.#afHdBxޤ2J<+5=PI~LtaYd@/G_*FV,#H9.&T{c0/sAn' vx9J꯸ۦ)q͝;wРAh޼yǥΘ1XDLA_qV&*))imm *//Sn^nyU%( 1e)~{(66vܹyyy#F)1Ϥި/3:Ғ˗/ 9q@RT`︟FLAۅp9;k׮m۶544|g׮]ҏկڽؑr` `עYGݹsg[[ۻkE@p։[f) ]+Zj0:;;[[[{{{#TtoqzQxgCqkO3zTk-H XE/jogGydݺuz?8j4dw$,<rkDt8iDDd(**rq0Q"1&sã`gs4nԹ3AAA|r;`om=3}K .'vj4L;|kBTRP>W^{)ݗ4+zRtPDf {;M¬?dvuut:T#?"c;KńgKe4ɓ'[YYǗpa1~#cCC߸{ t nϞ}2y+ 2} ,.PqH8N$%;k֭ trrG/⁤T&4@5bKN&#7ԜfBA)ɀ2qgLv9r˅X4ek$*sTǕ "!!!66vҥ GZ S!?:TKS ,[='\h3 qH`nw2Р ;K%3]2# :ywq]w궃'O9s)S/^qkkk'LP\\' `/[D}]ٞv}}}{{O^^z9dWxw.DvWVV*  3vv-Cf'%վ\Ȁ^ś؜5AT*oٱcGAAAMMMTTv38{O Dvo|⃝%bk5-YI/ -,, h71[HLo+A&֒E< q0ܯj@ƃQJT&4b:Qg'Lpg *c3HtFZS&.# PNJ5tPV{}E@8!ZvuumT5}a MUUU666UUUbIs px)BSۛ7oرҥKW\KKKNuZZRo*E1 Ң\\e;Ռǒߙcǎof:+--  Fmca!/Ji3g@b"σ=NƬ,GG7|s<[o8`LHg8fdvҵ=S\\|1SU\w7W:@jKFXPYYʡ\)VhhFY~ѣGlbgggzIΟKYYY=S<Ͽ߳gOgg'5O ߷o_HHȨQ~^z?x3\ROַOtzyy quFR'܉'ucccww7yRSSR5۫Rx񭭭GccVK I?wOա'***j*ݻ]]]B6^|ss3΃N===߸qCR\\n u/_CUUU͝;o}ǎWF*І \8E#"8ҥK b?zYqqqqvvvyyyicǎmmm-++۲e zS;wbbbfΜpqT.<<Ν;˗/Bb$$$,]4!!FKXc۷o;OF?HHH5 oF[qW^tyyy1z;wMַΎ=sڵkѱFFFnذ:/&-**tZfMFF*OIIEi42''rᡟ?𩧞zW_z%T#"" ~_h@AAE>O>>#wYhQnn?ϛ7oɒ%K,y뭷6n8cǺ:::>SmmmΝt~~~3gkkk 8p`mmYrsst:777;;t;;Ç3 0k֬{9::s8nӦM7n|]]]MϯcǎؿEEœO>9x`^?a___(??e˖̙3YB?诋ĉ[[[}}}=oΛ7/===44駟4hO<1tlJ2f̘aÆ C{{ottԩS-ZܬOO?Ś3gQyFFFhh(i0BCCϜ9/oCuN81mڴcj4Ϝ9w^t/mmm111.]6moƛm۶N8? fdd۷o$666==}ʕy+&&&=='((ԩS5eʔ[nZ>SNBl?|QQp޽۷o߾`0455=cU 6$ی3RSSy/--̙C~A;::}]V{ر_ <^ W^bŨQ;TX\\/>Frh442Rg"Xhllvڴi^~対J@j;w$?j*bFEE\2&&FJLZu1ֶط.2:/$''߹sg_:?; `JEq.\4hPuuO?pP"^; 63?cwwŋG~()6`0Hm2{SN?~Ȑ!%%%ǏG`xu()XKK?PPPaoopPRnv r ҥK^w^> rD΂ 󃃃}||Qrt2 ABQF͝;XQ=LE&3Vsss\\ܨQ{9zၠh獎= endstream endobj 474 0 obj << /Type /XObject /Subtype /Image /Width 64 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 64 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 446>> stream 8SgBQ\CCzf2CIafzLCd$WL2$Ir:sʵY9~|.Bda-\*_v|%OJ45+rV;2w,pfzYbܣ`hPI \d"bQ}RdARˠFIZ'{jlhp%d enڡ۝ꦿ[:B5F[0f2屟G~cU~H;)A\ڨŀ u[ւ2 gw*;slFK"]$L)Mrbo!G[ Y!>Sê_> IJ Tr ~G]*F YrVk͔$-Р^Ŀ@IyUeR[#D? endstream endobj 475 0 obj << /Type /XObject /Subtype /Image /Width 64 /Height 18 /SMask 474 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 64 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om   endstream endobj 476 0 obj << /Type /Annot /Subtype /Link /A 477 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 154.6650 147.7500 267.1650 ] >> endobj 477 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coveragehospitalizations20.png) >> endobj 478 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 479 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 478 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 15913>> stream x}y\Gȡ(F<AE+Fc$?͹dͽF(jNC0$**1x((\ r_!7 LS]U3}o=ST]j_߽{d2LK.]vmzz;~#G< #gL6'""bҥo;vƍ }ݳg8"pf"0>>Æ 6lܹs6A*:~`# (A3i3=@=B_|ʹ4wyuQ_t+#.B)ZZZ:::ݻJJJ~駋/vuu]|ѣ qe[ZwUFFF޾}OMMs1#d It'N455ǧ$&&@\\Z6y(^zܹsп9rdXXXGGnj3=HB /N[JheO>ށNNNcǎussCK{;\<)(&1 <>>>f靝̥ Uleee]~Jys5Zf E)# D]aF Áe xU(P JSÙ3gBBB<==9,C۲ ׃PʺǏoذ6yk(?߷Jhk˄ KOm۶=y(‘G_p{ŋkz(A*zHA);;;  _NWY8PM1pdϝ[<P7lX [@RꅻcaW }@E{/J裏hIANlff-01i(Eff /poH$l\HGe2=:jj1bl|y( 'ZT)yh[l;ׯ_WWWee%[싞B <eqɘaNL<i[ E2\VE=CRP {{{Ʉnݺwޮ.Fk.J>QvDZbXH`B!/_e4?EHI!#$ī};w@TTTUUu|)>BKA)rrrݻwgggGEEUVV1kĤQLs#hA9ty銊s@IIy$3gx !q VqٳgbbbJJJΝ;W]] W#K@1 ERP tvv><>>>&)""bذa& `S2~sB(줍Q L:B<  3J#qhѢ%Ktuudf-CJTií_ J9p@Zaĺj*ԩS{zz@Dl3!H.hgK/|aa$LnBy(AML6 Μ9דġ8lG_H*PL0СCt"Z'.hLf򺖯"EKB?J@qqqǡ|0}'"JhnSHJAYJ(7$/b$eeeSNEsҥܮ.h1 儠R6H{쉍jᩩFQ#1,P{;sBl?㧟~:h \C JQVq/\뻻K{XBwb8ˉ\qƍ=F1 `߸F _x^ yw֬Y9994yӥP91p&2---""^C?S=Odʢr$B<}vuuEEE}TOk)#"=i("ă -!#J5DNM|5bd& Rnܸqƍ44ɱdgg(\4"orDt5bS 'øe'$aChӐS"1!1 &dۙH4nZH%RM~oʜ]?kܸqD-&aMz~F?W(J_˛;-::.V;::<<JP(&i…+#>O|fT?zh///___779s80̉.3L(&Baa;w4ͪU̙#-CBkF(ҙ׼ѧ~Z(#p//\Qĥ;ñ^i0lAΞ=B?}E(%6C}RMWlJi +%hlbJJAę3ɠIEuFjf1Se$aN9T2qMT#f-"I\Э0BoU3p(bF+(|0~_T!3MPN%5#|!f.x-y(f`k0̩䑇ݦ7ɌR"vPT ggg6z}aaaTTq3P_kO"#M*rJllhEB&<&oEyQQq| ZH%GRm J77z`+ٳh4ŋ_|'^V =Aq(:FFFvww;K.MHHj .+F!XN\摳șTPPP__lٲ;;3f6s >ѤRUTTKR5JkxK$K,u={^!V OejCBOCَlu2I9dgggJ5sLf֋b;MU\z%Q~]Խz=!xP`()GEQ/ZL6<I#`ha /ʀ(+𾃄"$eU455-[8(kZp@-YbzE /j0#q>}n %eCd0 MMMѶDETcGޕw4s8BjfCɴnׅv@Z9%f(3 uuuEL7oDǏ?8pu)=oh|Aqd䓚DVUSS#ܼy=]`F4*ɗ/ggpj…3f -$/[lȐ!&Lw ;ZyQ>F&mƓy -@YPPܻwo{{{```zzzvvOX/7Wi 9x"a*W: d")ǎ&0[Dr^\T0a v%(h[oY2a]]]IIٳ6IYJV"nʯq٦8@) f0#e5vF%1$' 8%Y0:{_-//G_~&##q|0v1"#&Z`6 q\Jo6{BɜHb&0&O#F(++۽{,j]lI+Hϟed"~ZMyZ۞tZr7tv#Ϳl ȐR1GDE⃝Y rҫ6@Twٶmۖ-[lَa,d`F.J2fR# Zo޼rN=tHaT4n8+kjj^{mQNyG'%\j[nݺu(Y$W7"U.`ai5Y?pwo)V hER=> ,9:t1y,CxS_lSPIBҫ Acl I OĚIwָOsKf V%#9kBc0SJ9z,때ʵ&OB0wgT5N?3, cg]$VVuJn΢TIܓaSRJJӦL5`9*-6zєp ,}\XeU\9,]]!w@.bʑ$4`ݻY]zH%M+j`QcaåRill,//2eJsssqqqhh(5,3iNKP2]]TVVj4߼yϏ) (e!5lnƗ҂Haaa|IĀuYC ~s)W`"H*2w5yB_~YZZo>}:77wӦMUUUf>ɷg{|j^[5ѾB|`>>ܵkWlll]]ݶm`u--YwCqD*g .R +vttzt*ӧW\5tPooa  EEʪh׊ dЮ*..׷ ?ع9;9@ 1tqkU&^__֦j]]]//fK_ZZZ8+**9| ޟ4mbGL؂祋fϞ}ɓ'_%q:ֹ/b#V)I8C/q+ 0LvvvrBF4o#>MP ROO;1OlrfČ!-a='xV2- :sm B)h>|PYbn1hy*EFl⾡tzk :RRRR ///22LH 秫0AlnXBt.U)E TWW;w0&uOP; r-[z{{={v ހ@3 }1/ }'''gћ6m8qɓ'GETфa #agt_ʙ ]766Ɯ<':;;}||f*ExD J.8NRTׯ/\0##cԨQ+B3 -oxNTܑ#G>MMMAAAӧO'Ij~1p nj3`Gy$??Ş}A<Rz*l$O%3.ANF( :iX(0qDN* <yVT"Jd:%IK߃RиMrApGT|y XU[(23~288ϊmKBTcHQg'BryO?5kֶmۄ2Ɣ@.5D!,êT'd<.Hl[./B)/^ 6ym|YNm&ĠaIA! $tN/B)\]]ZpfJAA CNNΏ? &XJd_~Q^?K}2n.LL\:vHA1i߾}*J}WRl6Z'/̑mP2ٳG׏?>>>ĉ3fHKK0`zP"\)K@gϞ1cڵkΜ9/rbbN7o4ap (x[*++z]vQF&3f8}̘1&IӅ)L ׷SP 4hƌo|#枞˗//]Tӵ4hӧO DZbv ib@oڴ)>>M aaiOY vӜR R̼Ҟ8(PJj_B('vdڢac~UtttTd-b 򬐃7O[: Q-S[ h;Yzz'D %#tttTTGqA <@9O^"So_`vgy S$25|m`>{lRSn]gh>@lU(D¾ 6΃sMwյ7[. :Tx|'0kfnӔ Woߞ4i],ۮ¿$<"@a&hU6ZOcBkJ9o޼&www|XN3Uh +VL*4[+P 7o VTT?~h`g"UrK-9¯baoNLLyɓt+Y.ܥ|A$|llpL&E|Ge d2Oػwӧ333RfRE777OOO0rH z0%"7ӴD  E:~ĉΎ%%%7x`&80I塔+V~[XtiOO;eD^Mg%8ڵ ]@aa-a6F BdRhU_̙3Æ 4hȄEPʴ4kׂx TPPsvRR!51)b?>X`0A{r\5I/s[^"jo|9ЩqN˵Ic3Av1QrثKOX\}n˪?s].:.J _B @L[1xRIyr\4R4PR4&Yܽ{Wٷo߈˗ '&HWf"/5]Tb!q(aDQ0&TfNX".R`;q?tw6uT`; =d 帀6SIŽ4ٞHNj8B*L(OD  q_Kcƌ5kJ]]]aaٳ9zԩSE幹oF^X1\mbVBURRV^^'ܜJ(zVWO ,/CD frvv6l^iT K]VVWXlTbrqح+~UQyzd2>ZD^u}]fS_ԽawZFజ:cHB-,`NI~XN0k]]N} HqQ҈fC Ik/7ԜfB%:BR^f4 0ڲ݄v^cG_,afw (N6-88xѢEǵԌ7 Po-˧X>cd!4,2d]Bwkյi"\!^Q\N`gq JR(ƍK/MQEń3\q֭TgggR _}Վ;󫫫cccp/DG޲<2iQe㸝;wn޼믿,{0y0-g}aÆ2bHB'Y^KYJ8]+ѱ!:֭[vvv惝{%L< 9,vM0Z㪪93r BĮB﵄2⃰ZeeS{{ǽ) !ֈ6Edi^Z$R PΝ;/"Rݻn`7o#$ToJc>ުt>$1]8ph4gjSR6n)ѧ$#GN֙3g.^Hʘyb8t{y)JYZZzΝ]vJ%Z`$}%햯dK.: xdm޶yNFÃǐP59}F|[0698e~s8//jUnS,,IYki~I4OrS(h@шmptFBKFq0tPfZ]{%@ , GnhYuCY{i3WV~$_Ml@I)Ðx9l10F7pP`އj_8ٴcV+YJtr6$(U@O؋ҁ$qpx!+KTo_;*x1M=[7h*on &uB}ʘ .-LgZZZ**HeeڎybGp_QC٩V ~+R! F}>>츓^3Dh4zãvbRXf܍sR_mo?E5%E*+++++* sp].ܙXEK)Ʋ.D$O믯_cǎ_x/--8.in~8PJ >9Y!>Ľ)1/>r$; ;:SRR"""vQPPW_m߾`0曥…zwph((o"?0yr2σt%% ...ʜ9s|W_}544YbOrb=vXJ m'N(YWnJl.:Td,ݰaVݸqÇl8rHA-__~trrڳgOgg'zO ?ܷo_DDĈ#~gy %w޵ZmyyZnkk+++߬onn&ގ7 uuu uuVV7܉7uCC^7/juyyV8{zzj5/~5hhhtxd8Z@:NVuuu Uz}[[/~} AT[[k0:N=Q.| !^g}… h\ۖ-[T*sݺu=\KK ~?Ƈ*??Æ v  w^B؛L?n+o6|S;vzw:͛V:x о}<==>뇩Yo߿ڵkn ur֬Yx;vXf T6mE)zf qqϟW(7nQybbիWsssU*=l˖-藪ܹ?mڴGQQQwYlYee%… K,p?j?@GNÒɓ'[.\1Lh+ҥK!77?DP.]s玝ɓo]ߺu+!!ԩS֭C@RRʕ+cbb6m_c𯅅k׮D婩NNN555:V[VVZ]]]^^./_^xgPh>'Oxkm6Ǘ3gΠ p7o^ff}6n܈JWXO?<v TWW q%Zi+W|G&MՅV^]XX755ܽ{w۷o7L%%%񍍍 ,@!<==NzUKKKۙ3g wqqqoN;rȯJGFcbb~k0p5k<#FoPaqqO?zA!Z-fxokk>y$)::Zj໻F#^> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 383>> stream 8c`0b ul;7c B*fXm%1 `;$k՝5e{)80<.4ܦAx@T߅ oWlK s@R6bAW1猞Jц TA  ~I0SUsSĤ H`ѿ 8${8x|Vt.̹`,{&Gҏd0֜3@r) ufLdDa?`cB׀T@I?KO(@3DaCL CB?вYu$I "Y _p+eapraS#pV VDI ltׯ4%|@C( # endstream endobj 481 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /SMask 480 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om_x \ endstream endobj 482 0 obj << /Type /Annot /Subtype /Link /A 483 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 573.5550 147.7500 686.0550 ] >> endobj 483 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coveragehospitalizations17.png) >> endobj 484 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 485 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 484 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 17224>> stream xyxTEV'$!!aK6(((#*2:DQPGQe\QttdP( lY"$I'ꪺ7:'ܮ{ꭷN:u{aXy晕+W:N9gΜ|0==OLL~衇kJ) HU):RM֙>ϯaaa#G4L{/%1J);`>j%,;ݻw|||ttt\\\lll߾}{ 7hj+:JP(ӿn3!!2cƌCSx~P>S8l?SEϳL㜜G@ɾ/傂vsr U dM&Ӿ}ᥔHk% z |ӂkW5e/Qb%X(ӕ+W.\0yd"A)\pqPBu{>Pʠ2LL61ALң" z:]kPҕ'QvyC{{{eepVJ((Zj 4Ku] e 6bHC)/ e/:e#OW|5{l%1\n oLk?<(L.dNP#F|Wݺu3ʯR=?͊8A rވ!\K=h\c J(sGGG```||H9!!ӓW\aÆ3f;v,-?%~<3R0<'ukժU7x?nܸ 3P2!!C<@@x(շ~[SSe͖zp\hK %00n3E%%%L~x̘1 ̸GNBgucaYh̙3͛7~x ,e'y~hP&M۷?mڴÇp'ЃZJ(see̙3ƬYf͚>|X-e]y=!CBrss5+w)@Tf{+vő<%-eO\ty1UTTlݺuȐ!f B M8A%AH:EGV˾8֒y^S+TC=v % kry~J`%RBN'+:{5kZ[[VX!ȎdW-"3- J(֭s8[n&J{B9o"믿~y֭+--ΫW>X*,x< L~~~ʕ+Ϝ9nݺݞrY3j[nLT֫VڱcGQQў={.\ ?"!i".;@^ ɇMzBݻ 6lؐgϞ˗ʹ1 PJ;);;oniia}[bccNɓ ]{C@Eh);&7|㫫o&dV~SGR:|Yfz뭭1.=CޯeX,/f ,N?nCn"39~'?ĉ.Lx7c(2 &^prR4rȼJ^ZlDSzR_4q( ΐbePʼAʔ4evikaGDl)E:#+C ?!1MyJ`^K(*Pfz$É[_X 4{Pª /J_ESy9$J#G66{w\__߳gz9tZ=D%^x:H9 e-~ ?S=c1[r:חuUb22ػwm'`M}W0$Ͽ_ +{B[^BgN#G3f ''ĉ .LMMS]?-魗J51'Oy)))T_6 3[o #TQ;::<8c [AITTTTPPJzCeff=:++ui/ k2^Nآq7nlll8qbZZ࣡)x¼A >䓷z+"""22mP^ˇ֑R1hll~ɓz)VGa'Nx}q+IHi2IQڋNP $))RzEWOADU2N[M7K{iȹ`+=(SPPPkku>^OZEQېFvɰK(IjaCZ<\JIF wƠ]=(%K,YWA%FjTQP2O#v*++ :T/r oFJ"W~N[@2};d=>zDŽOCA&=;! >(ׯO[+S. ĹO^Pf\WKꪷhz Ʌwn@/NR")XR/A)':s@2B>pr:#'J(0 "D|뒏A_RP& !h֭._yf}y~asΥؾ}{AA{]2-FP>e|8Vz;gVfү_͛7WTTp Xӽ 6([:uUjkk{yȑ߫VjnpzN5#L;vp˨QҲ,XvA]}Nzc~C Vg1_^xbbb,KssstttYYY꫐W0yT*k:wn6+++-_luڢEd133orJ}}9sϟc~>>>J #3yGe^B]XRH%Bubx?h+^@7P&M@A86fe9D71z(/'Bm(ܹ=FΡeD> + 1)y9*S8q]vmmmB*(YJ9}II gݷo/+]~K/.?zѣ}ٶ͛7%%%ɗB36"e#@Brrr?555%%%}7la0d<`A\b8q?\PPЯ_m۶B%_y>}d2;tΜ9Og>iʲ9s&44t={޽iӴFyr J{ N6MG;%c~:A㫯?҄ځF?%"^ 3_mm-{'&PB my %޽;99gϞBu^K(D@>@ O^5 d;rP(3T1xI5<3 d˅^VW0z7jD9P&~Hx PeX.'")ȭ_pxުVBix(%I! C)W+(/}h' M9`Zuk cq?yAJS3šcYyC9 g322y՚o666(J8ma1k}w}wǎZ|,3_H=wf6%\ JhK(m@^B,KUUUjjAფ қ*GJDYW]BDrauNu +L---YYYC(X Tjt@*RvC 1JC0Rb*ϥA/6P .-8afu(%.k٬VR~҂Bsss[[4^sCC<~BYԩSGK=큧|Vs(,jUy{[1-]$蒳>of8_cSEwo}7x`=&P)9%Ç[,j@8䒫 }42oc=fy&$$$ K&*홈)WC{搐6>|ZZڃ>X\\|[o.=c#TA )ǎ+((Xp_~ɾ/̿D6v6$?r[*zμy?dȏB[wU2ƬPݻWVV[^p7nÆ cH\7fRA^G^jUGGǰa6m4gΜ8kPRdA K>Ⱦ}rrr*++ΝsXOC`i!A/DySh^{l4iRttnL&qE.1DR4# 'N5jT@@i|}}͇o@V/ ӧO߿bb̾svR,zPʎXCi.++ ȸ{!<q^:TyŗΧ~MJJM&5^+ 0`G}ĎWZE)ݽ{wJ(bDC.\PTT4g 8+} %2`(]C :<ˠo}4+$$%+5 M>t_tfᦛ5ݛE+Q֮];w^z9>F.C1'<A(ٳAsrr~5k455%&&9s;,--jN٦( !dժU FZn7 q̙p80RSC\;޺^c:7p\ LY"'P=t/}ѹS00d҃#AH´b?)L'Nloo?{^g2Ge=&6B:˧e ֩SfsTTTZZ̙3vFdeQʔsСvKII9sLҪ1]?S5Yr;лw[_pܵ('2o/%T]l4pTBࣄr'8:Q\~\ ِ544/Wfs"㊱tQE37,,xΝ5Ĵ2<τc!y"\.©\GKK1NIJm)|{O5]Qce%3g̘1cٲeu~lH倠H_zVVʇ~H׷SeÇ%/sTUUK_%׿cqFv๱GFWYeyeӵ£ՆPJuBwFjXΟ?ꫯ.[̻uB:[+ ![Q.:T;xG8uj;52rG2lej,oq~S)"//Nl@rw ERf4:jB닐N+P $P'V!c~10UFI3`e89N x$Sm(/3F=ihwc4FOWU8d%*JPPB]Ƽz]ojNEi&{|@L'kVgSHO=!\$x+)]ܘ*m v T;թ v}kLtKMƧE>]ݤCUNȟU]S2!_7FLAOћA`SB\c)3ܨI0MuuS!uuu[۾ZE" Q[;T QJJJ233:uEY%W>>RǢ+wzVyV8 iAZ_ͦ~|OeC('EAwфSJ5A) ,<+@b(e OT$tȑ#.\j*wiYg@Oח(gϞpȑk.ySC .N۷Ϝ9U/QB)]ꪠ:7v$,,G^lYyyy޽w]XX~;o@V`R_뛙9x'xdԨQ۶m4hPGӆA}Q*q ;v8W߶*J tD,t~9sӧ TXXx]w =⪝KwdqqqVVo喚뮻N #ް ~)x555gΜ2dHnnٳgixM/cAD=QCBc&l'o4_%Ta?&uYs-FX8-{PWNAZTx*T* ҫ_ =(Ncl{P&2B0H(3!bBP=(G 2 @ +OZ6GՑx1 P<E97I`n ߀2[SLyWdUכdYaѥTwJn:3qHPٳg}5s./0mЄ 98PJ1:d<%9""&8qb…999NZ`aCyV>sx('O,));wMBCCaGazPߝ}mE0 ^`1{o޼yџ|-ܢGހlc5vj]Oh6!@1vTshhh^իGe˖o?~xn؃ŒB?甡RoyYzuss!CVX1mڴ{,55m|B='h`ZC8{lIIɽ޻b 1hРm۶%''_{zWң;~1!hdb^n]=AѣG䴷'$$$'';v֬Y.R"k>|b6mbԩ]w0'ѷo_y7N6f[zgwv @u2PPhw}ʕxGĉ-Zp8Ο?/t[hU62^x8ydBHnnKٺw|J҇Dس Z~=ڵߵqeRC@ +ajnn...>x𠖃sM<¯fe3xe6+PP B*ՔN DQf3LAAA)~$P :|e(aZȳJVXiPYR? *wm  0&DPs?عJ{y`>}zMMMTTyWUU}^oIIx, f*ߖ}!)<^҅Z+@A#(4UKv  }jZ6f4 SN1 eddq/_޷o_Y>}@ Fܹs7tۃQӎ||Y棩<[ڛfvb~gs޽s 0SG@Tt&tZVfү_͛7o;X- Wj`ժU={ܸqA)^E“~8r!VAmNz]cc@q! * h{r񴴴 l۶ws!F~}_g8m%6G3ʙgP1vip 9,,,99ZLLbinnPk:s|\[V36yr$%OHwн{wl5dȐn>5EM"8\___.`у{b7%؆SN Ϗ=x䀀::FPJH;p19< :p/EEE/_nnn?>{N6gGX ,'I?.b v Jqeu@)_0^i4@Z#_ RtX !.VGJ2<tgzMAv$!N!az3:)S:&U'%&YƊYn ń-s2 J͔v^ 7uHIc* AUÙ?Pf3_-[v5d7~,DH%@`%!j$_Lki!iKI9((hɷ~c uFhLԤ(T²'HOAw{kNJ'|HIEd2bq]J Gp^_WNr{xNX~*fI@h&$H"#.7w9 AN Xgp YI P z \6؀(0P_ IS'6n]Jw!CL2%<<͝:u*!رcǏZ@$h8@0 mނ p(/+H~~~}}q ^:Li10P *҆.yM $22"L B(ON;w2eJHHHVVV߾}ݽQZ !@άŮ10q"!!  }:Y”?h|ɹs6o޼vZ(E؁BJO=Sa "h 㧜+VxW+++|ͣGX"I1@!`#J:Z$i"IJk?M/_nZ}K.*rz@`ʔ錛jt=LZ87+a'ONgKKKMMM}}OUUn\%fBzi@_BLDAZ+c(pz(KHf/yCLi ]1^{hE G v;{t aG-T1XEs5B f617|yʍ7C9(`(pRZFJ4-m (37ٳg͍ڳtBgD(^MLh3+A ̸qO;w.:/c}4VB2`p<+u @f_fΜٻwoM敠< }.5RXwPjh.#(US Q @xOSd)=UoeG ©/`9V&F^ ,) +{uIȘ2R!|n춴:G;؎ P% _zPFH7J[-NU 8+sQQQ{{;{8S9^`R !~@,`:Y(>}:#[[=M(-#U32Z[n+o )ןēUp=`" reK#*0rdr*ƣ5XQQQ~G=9  A1+ߕ,ЀJK@ب{4exSe9V 9ً Ja/|jR=0| \n4/}c%)722p]ZC"V֬Jn/@=XL&w˽.LƏb3$eZ(D9&}hۅx꫼J6t~ V bZH _t[4VwvM?M|Rձ>y[/6`9p1Twbbve-,̀\l05j„ G5k!lyyyܿE| (ce7#!Z0u)!!!++=>rVJK)@: TLm)%ZCIcU\\l2BBBΑ@V'cgqvLs (9A⠱?ZZZWWWUVVן={ǵs4QhAa!'`T &Ϗr{] @yy9!ŋ\2S@HFx@5}4 v -$$:&p P6KJJ֮][o5556vP(&PEH=<<|hc! 4 f} 0?~ӟV\lӧ6C%0J &vi4Ji%!Jtu$rhC GQ$HiU4% $/ ^LBBG=(ApA8tm0%@ BzHsϿ{d: B0;3B"("d4  BB-Qs]Riw>}ț @-H0S)WΦTK+_U(V@kO@]_= @|SLI;7EFB& h)}{>FM;M' 7h:(mƊqƹOS ! @+褧dbe' !V+v X TP3Rs۫hiiX,zjkk~rM@oKִ-;'*MkkB444GGGwMPq R,#ۯ}tAdZ↫k+Yv~D)%Z)))ٳ_II LXŔy/e`S6ƪnpܹQ]Gt>NV Ү|O?oݻ/ҥKn]m}J~umqXemEgЊ<&<|V;/v!Z<im6uʦF{_XWR U,$&2''֭^vɽc~';;>000&&fӦ/ =\6V d8~p8s>ՅZWa k;&jh;9Zl Rʞj- WUUSNjkk/_lX 5MnXV&)UUUmmm|4VrIyyn涵Y,/jUۭV+9aR^^` ;::***Q !3c:۷ؿ?WlٲżE~Ẻ:kUvvŋWXnٲ%22r͚5Aw:֭{W%v*33sҥ=|ܹo޼Yz+l/oދٴioeNs=v'NhVJMM_º&Nxdʔ)|MMMo}>LcW`!{5LK,ُEBRSS;~ ==}˖-kmmp-[L0!99oau׭[ws疔0[#466_@R%,{X<̶m[NVܡCm6[VV+tFC?g̘1NbgϞݹs-ZĶo߾{gÆ O<4J\g=<---55500&466DDD\|P{祗^}Qñ~=z,Y^;Ξ1ck/]h7͘1#33.22?O^^ԩSgϞ={'|矟6mnvlaÆEGGN0aذaV5>>~رݺu+++233sss?l􀀀>}XBCC+Wܹܹs'MDyx ::W^۴ .;Ʈ]nt8ÇOLL*--;vƍ 6gΜ۷mdQQQ#F-,,OLLܴiҥKNx⪪wrK^Ξ=kX95hР޽{'%%;wn@@ljjJLLLIIkf̘QSSp8ڏ?ʀOp{kҤIǏg/5Nŋo}ݬ>y1c y$o%hQQQsmv5״2 555W\y_uәe˖j͡C3~cǎQJ/]e˖_&MB6xsssuuuJJʳ>_@)u8׿l6`y 0?dyyy… ###F6(V۶mc֯_7))))))/?x5\s뭷&''k˗?111.]666677b۫m/777V*}{7n8a„naƌ'xbO<+innnllr矦Äa 6TUU Yw}׫Wz^_4i"=:f̘xw5&N|r-X@i.1;::7n8yoٲEϞJ~}|a^^vv6_8=G|!9rHzzzSSzw&%%㑔+Ȱ|b &AݷoݻKKK2(~GV?nooOJJ5kˠԈ.[YÆov׮]=zo 0p 9R裏#""ׯ_ˠF~d[:f-/?*}!ga.\8qbBBByy9?L2\(ށ&N0`)S+_ePQ> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 383>> stream 8c`0b ul;7c B*fXm%1 `;$k՝5e{)80<.4ܦAx@T߅ oWlK s@R6bAW1猞Jц TA  ~I0SUsSĤ H`ѿ 8${8x|Vt.̹`,{&Gҏd0֜3@r) ufLdDa?`cB׀T@I?KO(@3DaCL CB?вYu$I "Y _p+eapraS#pV VDI ltׯ4%|@C( # endstream endobj 487 0 obj << /Type /XObject /Subtype /Image /Width 63 /Height 18 /SMask 486 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 63 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om_x \ endstream endobj 488 0 obj << /Type /Annot /Subtype /Link /A 489 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 364.1100 147.7500 476.6100 ] >> endobj 489 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coveragedeaths20.png) >> endobj 490 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 491 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 490 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 15913>> stream x}y\Gp) "'Wbb4j6k6&1J6jI5! DE#[/ef~(g4y~[O=,pF󄄄,[,''o6mp#/q g&i(k֬y=<<gϞ& DxBY$&&rmcc3rH___GGI&){3p <ϣ DPB\4+aÆy{{zzzzxx1bĈ ,xs-&#GVUU^LJE?Ą#BACCի&aACJbz `L3@JO8$o)%3I(\/8" "汅PMRL8R^J*\p¼UJ:JBfdR{{{7oܶmZjLLwAD&@Hʋ/~:.f{HC"z>{ׯ_y~Ν7o$EBJ<,ceee%%%rJWWWRRA !! KII9w\JJ ^x!mL&@:u9&&&999..R灠h~CY/^ ѣ:::fϞ#,A:?JxqT@K/ Æ svvFK{;\<)(&1 XCVϚ51+Ư7o655m޼Y(aV9rdD%f42w-**jii 5fB)(N ϟpss n(\B)O<wys3 ĉm' qג A藞۶m_kl_yZ#P#Jtp AA(0+WV{{{K2PTTRvvv8PJZi/%fcjȬxq-@2foKԌXt"l^4rŊ^^^(ZF)C' `0L(yLJꫯ&$$~C"aD:*ٔTs8TCƗo1pEf¾8wuuUUU}ľ.QDaMb fXfb˪Gr(B*Jaccj0PQvv޽{j](DmJFhɾb! $NJJ 'O$$a $qUھ};w <<ώ|R!B ֥666ݻ ëz{{KJJ5gbR(nlE ;{lEEŋ.%$3gx !q Vq܅ "##KJJ.^XSSR#K@1 ERP{'0 !!!#FP>>>K" B f'm=c3fhjjzG/˄둂y~„  XxqssҥK`lؖ!%`/4hJ EVnϘ1D6bюTꂶ;zF#ZH&» 23gz8 PI&9rUBiL~P^UdhIG8:YI(绻t:ˡsEK{h *3 mR^Zą )-n҆˰cD !Cak֭{7I'A4QEA őUg&12ʂA)ׯ_~z],Z`qdz3X.T~X 9":x/øe'$a=@h1>АS"1!1 &dۙ[H4n\H%RM~]~8w„ D-&aS֜<}[ cfEP \***N< 555'NBfD^#?=LڒgΜ)++ݲC/D (C.~fPw^Juĉz77 8;FFFZިQ8s͛m)=o޼ww1,,m+#~CC"͜YӃTl~q1Ez86&G}w "00`0<555##> ̴gee 0`رqpa]f8PL;wUVUWWϟ?_QK֌P3y#/P"cG^^oѣKOwc="J*`BmYE\p! c!"Kt@ Ə^H5!JY(ys%d`L+(*g"$&B LK{qRPL9(>$8se⚨NGZD[!?a 'ުfB P- L! 7 ŌV2P>hĉT Cf<#FKjF xC^]ZP4LaS#EMy(?Çn s긁"ƞ7~z &bkqd-|ס ngdd|mmmqqq}FQpD L jW_}uYiQ\d .9=/i(&mݺ5##e֭OtR.' m!}ԩ* i|wMLLlllLJJ:q$ʠLMahlLwWUU8ta1x,:{lmmÇ+++###Qtt4j莌DH(+B;n8^qvv2es='B8VTSV!㸞77aÆ 0qܸq'x;9f8'Qk+WD >-JL fŔ"~;::8Yp3}9,_,].ehB(_,RTƸ8;I(P-5 4a41/Bxrt:][ZZj5=!1׉[Jٙzj#b')|7LH.EBŋnT)$,,IJl: ?,))GGp&0E_C&TН$&TcׯpfCB)j/^R!.ތ%r6OmIANHi zzzzzzpR HJJRTt癭(>kJdƏIf"f9ԁo4zk@Fyyy?CwwwQQQxx8q3P_kO"&T~ڵ(^օL4yL\ )~s@/޽qw}օ2RQ\^*PFl 臭g^,Ydgg3 Wƒ(Vzzz=l2OOXF㏃~D,' ~ș䌏/,,lhhX|yllUttt``ٳyùYPٯgGc@F,9s^ bܹ< mfYb`Jegg7|kkkXtippT"'A33ՇU:Wcmmp‘#G*J}YC 8QLT;Ψxg9{>}:hF͜ /bo' _& (QF:,, .E"-4)dffFDڿxK2/1ٷysVgfy0wrvСЯ,G6;Y:tCee9s[[[\Y̫Ցfq@`GSD8~|-VP;$/kÉ;;;Gb=zܯ_?rY.5 ly G[CS,WDEY$!9.yAYӂhDKpK !Ydf3w#)ه &PR6dK& N,mK$QDu1x]9,qZL3#.f33ܹs<ϧO,iGC1LKDwzQGH ӑR) /_!8n޽/_>x`bb"TWW\Ä#+4}ˉ*r#ó |*K|J$''ڵn߾}ƃ r&"?iyᙒk[Έuх]]]C-,,llltuu " p=>n f@E}"Z.--C& OskGBC8_4H555Sno``e垾 3q...%M555 OmR''' 2Iyn(Z$Uyyo[oqN,[L8%\˔ Γ3&LbwO?Wm8$aoA[[!3C2q"Ʒ B ]?~y;?QE}CX'N(t` ]QQQut?2cLZQ iZybŰ_͈X@!߿o -D&;}T*դI ƶd)EV#RN<ǧ]%Z X+/[z{6T*H.gJ(@7M`(~2&$|5MHNNNMn{twN4KJY___RR2o< S(!!'WSMqkXPa#GQ!;5nZ ݒL^y< ٵO7NaGduT*L֖xt00=FA<#T8`#uC:8Ƅa0D冁:fׯ~ DRXGs:S⼼qO$Vmodz6 TFb5B2)ZfLaKGh f=~0lCC}ڋ6h1+)P\*%[,X't-"bGޞePf*Ww?,؂ĎyZuss^p!{T;khQr2 \j ڬ[ Jb3RbC,X=Sk }‘IHeL܂ *.RJv\} a655W)rk2'E7UUg _]pWUU iii)|aF(T(pgܽ!)#""**BhOj`疖lOAb!qoU{mmm mmm_~qǿa7ٯ.-$r7swݪ*G[u<l`#&lAEׯ_7o^NNN]]ݴi^xW_}Ux+@|ֲΕ~ OX$;d!nBʊP.#$A/l z{{DdbuI866h)ӢPC1iAoZGP T77quN` !$a:)(%ʛ7o>o3fLyy m81p /yyyG~'{zzg͚EC԰b677gee7nO>dAA%K8*x<&UX% H4ӟx1Jg(=](d PDt5}Pa6mD9^TPx* E^= @IuJqgMc(?# gSq=1_$`JF WnR39P dfYa9_epp492& 0 RΌO (>wm۶ et)P]jwBXY N&y(]2]R,Y +M) @lDP2MHA{?ÒCI2SR899i4̔Cte^(e tTAyǻtfOsabбC Ij|Miiɳv,R0`СMMMeϞ='N9uٳ_>p@CapA̞ӊ,EО={:::ƍk׮qqqZv…xDÁS~ʕ+UUU=ܮ]z1cN>0}t9X-xe"ٳgsWSS>n8j O?M"D1%$e(**rppT(AAA={6ϜsDCRPۛl2V>x!C̚5i)\0rFU^^aÆ4]3=qg-͞BLsJ1H1K{ldKB(} 8ؙiGQQYY>ӓ^6x]riK'q68*%yjrC-:KZfxdvvvcǎqA <@9O^"cKHA\*YEх 㟳3hv:DIZXS(D¾ 6΃sMwN~ԤѨdqtsD ׯ4e(eNNԩSMbK%K-ڔ f `o]\ `~d[91?\pass >oO,+?S^zk֬q\q|c_a0 ?| @)\]]z{{N+**N<|MMMDDp3HJ/JQ#ޜ8O>LL.]D"*---۷o>}1_vg/ Yptt 9r$x5kVUUFquuԡmGLjF~D~} A=dhBO<ή g&I٢ NSVTTttt\>cٲe...톴HAxܔxsz׮Օe # sf _vQ_Ο??bĈL()ap[?^|9-#<8q ׯ_Xf g@%r@yOώ͛_ IS8x(2p :ejNn_.7=2Ez}ϱ:y'suwi%夓c?gpBAA9{옘Ϗg:WĽ{Ux7azd^1萩#|LeIN;&!*SN{u)=5XA+o]z2'ecYx̞LV6>BPP:ӖEL8@x-Be@brPq<9t@)NJq()yb C@ѯ_=J.#afHdBxޤ2J<+5=PI~LtaYd@/G_*FV,#H9.&T{c0/sAn' vx9J꯸ۦ)q͝;wРAh޼yǥΘ1XDLA_qV&*))imm *//Sn^nyU%( 1e)~{(66vܹyyy#F)1Ϥި/3:Ғ˗/ 9q@RT`︟FLAۅp9;k׮m۶544|g׮]ҏկڽؑr` `עYGݹsg[[ۻkE@p։[f) ]+Zj0:;;[[[{{{#TtoqzQxgCqkO3zTk-H XE/jogGydݺuz?8j4dw$,<rkDt8iDDd(**rq0Q"1&sã`gs4nԹ3AAA|r;`om=3}K .'vj4L;|kBTRP>W^{)ݗ4+zRtPDf {;M¬?dvuut:T#?"c;KńgKe4ɓ'[YYǗpa1~#cCC߸{ t nϞ}2y+ 2} ,.PqH8N$%;k֭ trrG/⁤T&4@5bKN&#7ԜfBA)ɀ2qgLv9r˅X4ek$*sTǕ "!!!66vҥ GZ S!?:TKS ,[='\h3 qH`nw2Р ;K%3]2# :ywq]w궃'O9s)S/^qkkk'LP\\' `/[D}]ٞv}}}{{O^^z9dWxw.DvWVV*  3vv-Cf'%վ\Ȁ^ś؜5AT*oٱcGAAAMMMTTv38{O Dvo|⃝%bk5-YI/ -,, h71[HLo+A&֒E< q0ܯj@ƃQJT&4b:Qg'Lpg *c3HtFZS&.# PNJ5tPV{}E@8!ZvuumT5}a MUUU666UUUbIs px)BSۛ7oرҥKW\KKKNuZZRo*E1 Ң\\e;Ռǒߙcǎof:+--  Fmca!/Ji3g@b"σ=NƬ,GG7|s<[o8`LHg8fdvҵ=S\\|1SU\w7W:@jKFXPYYʡ\)VhhFY~ѣGlbgggzIΟKYYY=S<Ͽ߳gOgg'5O ߷o_HHȨQ~^z?x3\ROַOtzyy quFR'܉'ucccww7yRSSR5۫Rx񭭭GccVK I?wOա'***j*ݻ]]]B6^|ss3΃N===߸qCR\\n u/_CUUU͝;o}ǎWF*І \8E#"8ҥK b?zYqqqqvvvyyyicǎmmm-++۲e zS;wbbbfΜpqT.<<Ν;˗/Bb$$$,]4!!FKXc۷o;OF?HHH5 oF[qW^tyyy1z;wMַΎ=sڵkѱFFFnذ:/&-**tZfMFF*OIIEi42''rᡟ?𩧞zW_z%T#"" ~_h@AAE>O>>#wYhQnn?ϛ7oɒ%K,y뭷6n8cǺ:::>SmmmΝt~~~3gkkk 8p`mmYrsst:777;;t;;Ç3 0k֬{9::s8nӦM7n|]]]MϯcǎؿEEœO>9x`^?a___(??e˖̙3YB?诋ĉ[[[}}}=oΛ7/===44駟4hO<1tlJ2f̘aÆ C{{ottԩS-ZܬOO?Ś3gQyFFFhh(i0BCCϜ9/oCuN81mڴcj4Ϝ9w^t/mmm111.]6moƛm۶N8? fdd۷o$666==}ʕy+&&&=='((ԩS5eʔ[nZ>SNBl?|QQp޽۷o߾`0455=cU 6$ی3RSSy/--̙C~A;::}]V{ر_ <^ W^bŨQ;TX\\/>Frh442Rg"Xhllvڴi^~対J@j;w$?j*bFEE\2&&FJLZu1ֶط.2:/$''߹sg_:?; `JEq.\4hPuuO?pP"^; 63?cwwŋG~()6`0Hm2{SN?~Ȑ!%%%ǏG`xu()XKK?PPPaoopPRnv r ҥK^w^> rD΂ 󃃃}||Qrt2 ABQF͝;XQ=LE&3Vsss\\ܨQ{9zၠh獎= endstream endobj 492 0 obj << /Type /XObject /Subtype /Image /Width 64 /Height 18 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 64 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 446>> stream 8SgBQ\CCzf2CIafzLCd$WL2$Ir:sʵY9~|.Bda-\*_v|%OJ45+rV;2w,pfzYbܣ`hPI \d"bQ}RdARˠFIZ'{jlhp%d enڡ۝ꦿ[:B5F[0f2屟G~cU~H;)A\ڨŀ u[ւ2 gw*;slFK"]$L)Mrbo!G[ Y!>Sê_> IJ Tr ~G]*F YrVk͔$-Р^Ŀ@IyUeR[#D? endstream endobj 493 0 obj << /Type /XObject /Subtype /Image /Width 64 /Height 18 /SMask 492 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 64 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 26>> stream H1 Om   endstream endobj 494 0 obj << /Type /Annot /Subtype /Link /A 495 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 154.6650 147.7500 267.1650 ] >> endobj 495 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/12/coveragehospitalizations20.png) >> endobj 496 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 497 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 496 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 15913>> stream x}y\Gȡ(F<AE+Fc$?͹dͽF(jNC0$**1x((\ r_!7 LS]U3}o=ST]j_߽{d2LK.]vmzz;~#G< #gL6'""bҥo;vƍ }ݳg8"pf"0>>Æ 6lܹs6A*:~`# (A3i3=@=B_|ʹ4wyuQ_t+#.B)ZZZ:::ݻJJJ~駋/vuu]|ѣ qe[ZwUFFF޾}OMMs1#d It'N455ǧ$&&@\\Z6y(^zܹsп9rdXXXGGnj3=HB /N[JheO>ށNNNcǎussCK{;\<)(&1 <>>>f靝̥ Uleee]~Jys5Zf E)# D]aF Áe xU(P JSÙ3gBBB<==9,C۲ ׃PʺǏoذ6yk(?߷Jhk˄ KOm۶=y(‘G_p{ŋkz(A*zHA);;;  _NWY8PM1pdϝ[<P7lX [@RꅻcaW }@E{/J裏hIANlff-01i(Eff /poH$l\HGe2=:jj1bl|y( 'ZT)yh[l;ׯ_WWWee%[싞B <eqɘaNL<i[ E2\VE=CRP {{{Ʉnݺwޮ.Fk.J>QvDZbXH`B!/_e4?EHI!#$ī};w@TTTUUu|)>BKA)rrrݻwgggGEEUVV1kĤQLs#hA9ty銊s@IIy$3gx !q VqٳgbbbJJJΝ;W]] W#K@1 ERP tvv><>>>&)""bذa& `S2~sB(줍Q L:B<  3J#qhѢ%Ktuudf-CJTií_ J9p@Zaĺj*ԩS{zz@Dl3!H.hgK/|aa$LnBy(AML6 Μ9דġ8lG_H*PL0СCt"Z'.hLf򺖯"EKB?J@qqqǡ|0}'"JhnSHJAYJ(7$/b$eeeSNEsҥܮ.h1 儠R6H{쉍jᩩFQ#1,P{;sBl?㧟~:h \C JQVq/\뻻K{XBwb8ˉ\qƍ=F1 `߸F _x^ yw֬Y9994yӥP91p&2---""^C?S=Odʢr$B<}vuuEEE}TOk)#"=i("ă -!#J5DNM|5bd& Rnܸqƍ44ɱdgg(\4"orDt5bS 'øe'$aChӐS"1!1 &dۙH4nZH%RM~oʜ]?kܸqD-&aMz~F?W(J_˛;-::.V;::<<JP(&i…+#>O|fT?zh///___779s80̉.3L(&Baa;w4ͪU̙#-CBkF(ҙ׼ѧ~Z(#p//\Qĥ;ñ^i0lAΞ=B?}E(%6C}RMWlJi +%hlbJJAę3ɠIEuFjf1Se$aN9T2qMT#f-"I\Э0BoU3p(bF+(|0~_T!3MPN%5#|!f.x-y(f`k0̩䑇ݦ7ɌR"vPT ggg6z}aaaTTq3P_kO"#M*rJllhEB&<&oEyQQq| ZH%GRm J77z`+ٳh4ŋ_|'^V =Aq(:FFFvww;K.MHHj .+F!XN\摳șTPPP__lٲ;;3f6s >ѤRUTTKR5JkxK$K,u={^!V OejCBOCَlu2I9dgggJ5sLf֋b;MU\z%Q~]Խz=!xP`()GEQ/ZL6<I#`ha /ʀ(+𾃄"$eU455-[8(kZp@-YbzE /j0#q>}n %eCd0 MMMѶDETcGޕw4s8BjfCɴnׅv@Z9%f(3 uuuEL7oDǏ?8pu)=oh|Aqd䓚DVUSS#ܼy=]`F4*ɗ/ggpj…3f -$/[lȐ!&Lw ;ZyQ>F&mƓy -@YPPܻwo{{{```zzzvvOX/7Wi 9x"a*W: d")ǎ&0[Dr^\T0a v%(h[oY2a]]]IIٳ6IYJV"nʯq٦8@) f0#e5vF%1$' 8%Y0:{_-//G_~&##q|0v1"#&Z`6 q\Jo6{BɜHb&0&O#F(++۽{,j]lI+Hϟed"~ZMyZ۞tZr7tv#Ϳl ȐR1GDE⃝Y rҫ6@Twٶmۖ-[lَa,d`F.J2fR# Zo޼rN=tHaT4n8+kjj^{mQNyG'%\j[nݺu(Y$W7"U.`ai5Y?pwo)V hER=> ,9:t1y,CxS_lSPIBҫ Acl I OĚIwָOsKf V%#9kBc0SJ9z,때ʵ&OB0wgT5N?3, cg]$VVuJn΢TIܓaSRJJӦL5`9*-6zєp ,}\XeU\9,]]!w@.bʑ$4`ݻY]zH%M+j`QcaåRill,//2eJsssqqqhh(5,3iNKP2]]TVVj4߼yϏ) (e!5lnƗ҂Haaa|IĀuYC ~s)W`"H*2w5yB_~YZZo>}:77wӦMUUUf>ɷg{|j^[5ѾB|`>>ܵkWlll]]ݶm`u--YwCqD*g .R +vttzt*ӧW\5tPooa  EEʪh׊ dЮ*..׷ ?ع9;9@ 1tqkU&^__֦j]]]//fK_ZZZ8+**9| ޟ4mbGL؂祋fϞ}ɓ'_%q:ֹ/b#V)I8C/q+ 0LvvvrBF4o#>MP ROO;1OlrfČ!-a='xV2- :sm B)h>|PYbn1hy*EFl⾡tzk :RRRR ///22LH 秫0AlnXBt.U)E TWW;w0&uOP; r-[z{{={v ހ@3 }1/ }'''gћ6m8qɓ'GETфa #agt_ʙ ]766Ɯ<':;;}||f*ExD J.8NRTׯ/\0##cԨQ+B3 -oxNTܑ#G>MMMAAAӧO'Ij~1p nj3`Gy$??Ş}A<Rz*l$O%3.ANF( :iX(0qDN* <yVT"Jd:%IK߃RиMrApGT|y XU[(23~288ϊmKBTcHQg'BryO?5kֶmۄ2Ɣ@.5D!,êT'd<.Hl[./B)/^ 6ym|YNm&ĠaIA! $tN/B)\]]ZpfJAA CNNΏ? &XJd_~Q^?K}2n.LL\:vHA1i߾}*J}WRl6Z'/̑mP2ٳG׏?>>>ĉ3fHKK0`zP"\)K@gϞ1cڵkΜ9/rbbN7o4ap (x[*++z]vQF&3f8}̘1&IӅ)L ׷SP 4hƌo|#枞˗//]Tӵ4hӧO DZbv ib@oڴ)>>M aaiOY vӜR R̼Ҟ8(PJj_B('vdڢac~UtttTd-b 򬐃7O[: Q-S[ h;Yzz'D %#tttTTGqA <@9O^"So_`vgy S$25|m`>{lRSn]gh>@lU(D¾ 6΃sMwյ7[. :Tx|'0kfnӔ Woߞ4i],ۮ¿$<"@a&hU6ZOcBkJ9o޼&www|XN3Uh +VL*4[+P 7o VTT?~h`g"UrK-9¯baoNLLyɓt+Y.ܥ|A$|llpL&E|Ge d2Oػwӧ333RfRE777OOO0rH z0%"7ӴD  E:~ĉΎ%%%7x`&80I塔+V~[XtiOO;eD^Mg%8ڵ ]@aa-a6F BdRhU_̙3Æ 4hȄEPʴ4kׂx TPPsvRR!51)b?>X`0A{r\5I/s[^"jo|9ЩqN˵Ic3Av1QrثKOX\}n˪?s].:.J _B @L[1xRIyr\4R4PR4&Yܽ{Wٷo߈˗ '&HWf"/5]Tb!q(aDQ0&TfNX".R`;q?tw6uT`; =d 帀6SIŽ4ٞHNj8B*L(OD  q_Kcƌ5kJ]]]aaٳ9zԩSE幹oF^X1\mbVBURRV^^'ܜJ(zVWO ,/CD frvv6l^iT K]VVWXlTbrqح+~UQyzd2>ZD^u}]fS_ԽawZFజ:cHB-,`NI~XN0k]]N} HqQ҈fC Ik/7ԜfB%:BR^f4 0ڲ݄v^cG_,afw (N6-88xѢEǵԌ7 Po-˧X>cd!4,2d]Bwkյi"\!^Q\N`gq JR(ƍK/MQEń3\q֭TgggR _}Վ;󫫫cccp/DG޲<2iQe㸝;wn޼믿,{0y0-g}aÆ2bHB'Y^KYJ8]+ѱ!:֭[vvv惝{%L< 9,vM0Z㪪93r BĮB﵄2⃰ZeeS{{ǽ) !ֈ6Edi^Z$R PΝ;/"Rݻn`7o#$ToJc>ުt>$1]8ph4gjSR6n)ѧ$#GN֙3g.^Hʘyb8t{y)JYZZzΝ]vJ%Z`$}%햯dK.: xdm޶yNFÃǐP59}F|[0698e~s8//jUnS,,IYki~I4OrS(h@шmptFBKFq0tPfZ]{%@ , GnhYuCY{i3WV~$_Ml@I)Ðx9l10F7pP`އj_8ٴcV+YJtr6$(U@O؋ҁ$qpx!+KTo_;*x1M=[7h*on &uB}ʘ .-LgZZZ**HeeڎybGp_QC٩V ~+R! F}>>츓^3Dh4zãvbRXf܍sR_mo?E5%E*+++++* sp].ܙXEK)Ʋ.D$O믯_cǎ_x/--8.in~8PJ >9Y!>Ľ)1/>r$; ;:SRR"""vQPPW_m߾`0曥…zwph((o"?0yr2σt%% ...ʜ9s|W_}544YbOrb=vXJ m'N(YWnJl.:Td,ݰaVݸqÇl8rHA-__~trrڳgOgg'zO ?ܷo_DDĈ#~gy %w޵ZmyyZnkk+++߬onn&ގ7 uuu uuVV7܉7uCC^7/juyyV8{zzj5/~5hhhtxd8Z@:NVuuu Uz}[[/~} AT[[k0:N=Q.| !^g}… h\ۖ-[T*sݺu=\KK ~?Ƈ*??Æ v  w^B؛L?n+o6|S;vzw:͛V:x о}<==>뇩Yo߿ڵkn ur֬Yx;vXf T6mE)zf qqϟW(7nQybbիWsssU*=l˖-藪ܹ?mڴGQQQwYlYee%… K,p?j?@GNÒɓ'[.\1Lh+ҥK!77?DP.]s玝ɓo]ߺu+!!ԩS֭C@RRʕ+cbb6m_c𯅅k׮D婩NNN555:V[VVZ]]]^^./_^xgPh>'Oxkm6Ǘ3gΠ p7o^ff}6n܈JWXO?<v TWW q%Zi+W|G&MՅV^]XX755ܽ{w۷o7L%%%񍍍 ,@!<==NzUKKKۙ3g wqqqoN;rȯJGFcbb~k0p5k<#FoPaqqO?zA!Z-fxokk>y$)::Zj໻F#^> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 499 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 498 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 17224>> stream xyxTEV'$!!aK6(((#*2:DQPGQe\QttdP( lY"$I'ꪺ7:'ܮ{ꭷN:u{aXy晕+W:N9gΜ|0==OLL~衇kJ) HU):RM֙>ϯaaa#G4L{/%1J);`>j%,;ݻw|||ttt\\\lll߾}{ 7hj+:JP(ӿn3!!2cƌCSx~P>S8l?SEϳL㜜G@ɾ/傂vsr U dM&Ӿ}ᥔHk% z |ӂkW5e/Qb%X(ӕ+W.\0yd"A)\pqPBu{>Pʠ2LL61ALң" z:]kPҕ'QvyC{{{eepVJ((Zj 4Ku] e 6bHC)/ e/:e#OW|5{l%1\n oLk?<(L.dNP#F|Wݺu3ʯR=?͊8A rވ!\K=h\c J(sGGG```||H9!!ӓW\aÆ3f;v,-?%~<3R0<'ukժU7x?nܸ 3P2!!C<@@x(շ~[SSe͖zp\hK %00n3E%%%L~x̘1 ̸GNBgucaYh̙3͛7~x ,e'y~hP&M۷?mڴÇp'ЃZJ(see̙3ƬYf͚>|X-e]y=!CBrss5+w)@Tf{+vő<%-eO\ty1UTTlݺuȐ!f B M8A%AH:EGV˾8֒y^S+TC=v % kry~J`%RBN'+:{5kZ[[VX!ȎdW-"3- J(֭s8[n&J{B9o"믿~y֭+--ΫW>X*,x< L~~~ʕ+Ϝ9nݺݞrY3j[nLT֫VڱcGQQў={.\ ?"!i".;@^ ɇMzBݻ 6lؐgϞ˗ʹ1 PJ;);;oniia}[bccNɓ ]{C@Eh);&7|㫫o&dV~SGR:|Yfz뭭1.=CޯeX,/f ,N?nCn"39~'?ĉ.Lx7c(2 &^prR4rȼJ^ZlDSzR_4q( ΐbePʼAʔ4evikaGDl)E:#+C ?!1MyJ`^K(*Pfz$É[_X 4{Pª /J_ESy9$J#G66{w\__߳gz9tZ=D%^x:H9 e-~ ?S=c1[r:חuUb22ػwm'`M}W0$Ͽ_ +{B[^BgN#G3f ''ĉ .LMMS]?-魗J51'Oy)))T_6 3[o #TQ;::<8c [AITTTTPPJzCeff=:++ui/ k2^Nآq7nlll8qbZZ࣡)x¼A >䓷z+"""22mP^ˇ֑R1hll~ɓz)VGa'Nx}q+IHi2IQڋNP $))RzEWOADU2N[M7K{iȹ`+=(SPPPkku>^OZEQېFvɰK(IjaCZ<\JIF wƠ]=(%K,YWA%FjTQP2O#v*++ :T/r oFJ"W~N[@2};d=>zDŽOCA&=;! >(ׯO[+S. ĹO^Pf\WKꪷhz Ʌwn@/NR")XR/A)':s@2B>pr:#'J(0 "D|뒏A_RP& !h֭._yf}y~asΥؾ}{AA{]2-FP>e|8Vz;gVfү_͛7WTTp Xӽ 6([:uUjkk{yȑ߫VjnpzN5#L;vp˨QҲ,XvA]}Nzc~C Vg1_^xbbb,KssstttYYY꫐W0yT*k:wn6+++-_luڢEd133orJ}}9sϟc~>>>J #3yGe^B]XRH%Bubx?h+^@7P&M@A86fe9D71z(/'Bm(ܹ=FΡeD> + 1)y9*S8q]vmmmB*(YJ9}II gݷo/+]~K/.?zѣ}ٶ͛7%%%ɗB36"e#@Brrr?555%%%}7la0d<`A\b8q?\PPЯ_m۶B%_y>}d2;tΜ9Og>iʲ9s&44t={޽iӴFyr J{ N6MG;%c~:A㫯?҄ځF?%"^ 3_mm-{'&PB my %޽;99gϞBu^K(D@>@ O^5 d;rP(3T1xI5<3 d˅^VW0z7jD9P&~Hx PeX.'")ȭ_pxުVBix(%I! C)W+(/}h' M9`Zuk cq?yAJS3šcYyC9 g322y՚o666(J8ma1k}w}wǎZ|,3_H=wf6%\ JhK(m@^B,KUUUjjAფ қ*GJDYW]BDrauNu +L---YYYC(X Tjt@*RvC 1JC0Rb*ϥA/6P .-8afu(%.k٬VR~҂Bsss[[4^sCC<~BYԩSGK=큧|Vs(,jUy{[1-]$蒳>of8_cSEwo}7x`=&P)9%Ç[,j@8䒫 }42oc=fy&$$$ K&*홈)WC{搐6>|ZZڃ>X\\|[o.=c#TA )ǎ+((Xp_~ɾ/̿D6v6$?r[*zμy?dȏB[wU2ƬPݻWVV[^p7nÆ cH\7fRA^G^jUGGǰa6m4gΜ8kPRdA K>Ⱦ}rrr*++ΝsXOC`i!A/DySh^{l4iRttnL&qE.1DR4# 'N5jT@@i|}}͇o@V/ ӧO߿bb̾svR,zPʎXCi.++ ȸ{!<q^:TyŗΧ~MJJM&5^+ 0`G}ĎWZE)ݽ{wJ(bDC.\PTT4g 8+} %2`(]C :<ˠo}4+$$%+5 M>t_tfᦛ5ݛE+Q֮];w^z9>F.C1'<A(ٳAsrr~5k455%&&9s;,--jN٦( !dժU FZn7 q̙p80RSC\;޺^c:7p\ LY"'P=t/}ѹS00d҃#AH´b?)L'Nloo?{^g2Ge=&6B:˧e ֩SfsTTTZZ̙3vFdeQʔsСvKII9sLҪ1]?S5Yr;лw[_pܵ('2o/%T]l4pTBࣄr'8:Q\~\ ِ544/Wfs"㊱tQE37,,xΝ5Ĵ2<τc!y"\.©\GKK1NIJm)|{O5]Qce%3g̘1cٲeu~lH倠H_zVVʇ~H׷SeÇ%/sTUUK_%׿cqFv๱GFWYeyeӵ£ՆPJuBwFjXΟ?ꫯ.[̻uB:[+ ![Q.:T;xG8uj;52rG2lej,oq~S)"//Nl@rw ERf4:jB닐N+P $P'V!c~10UFI3`e89N x$Sm(/3F=ihwc4FOWU8d%*JPPB]Ƽz]ojNEi&{|@L'kVgSHO=!\$x+)]ܘ*m v T;թ v}kLtKMƧE>]ݤCUNȟU]S2!_7FLAOћA`SB\c)3ܨI0MuuS!uuu[۾ZE" Q[;T QJJJ233:uEY%W>>RǢ+wzVyV8 iAZ_ͦ~|OeC('EAwфSJ5A) ,<+@b(e OT$tȑ#.\j*wiYg@Oח(gϞpȑk.ySC .N۷Ϝ9U/QB)]ꪠ:7v$,,G^lYyyy޽w]XX~;o@V`R_뛙9x'xdԨQ۶m4hPGӆA}Q*q ;v8W߶*J tD,t~9sӧ TXXx]w =⪝KwdqqqVVo喚뮻N #ް ~)x555gΜ2dHnnٳgixM/cAD=QCBc&l'o4_%Ta?&uYs-FX8-{PWNAZTx*T* ҫ_ =(Ncl{P&2B0H(3!bBP=(G 2 @ +OZ6GՑx1 P<E97I`n ߀2[SLyWdUכdYaѥTwJn:3qHPٳg}5s./0mЄ 98PJ1:d<%9""&8qb…999NZ`aCyV>sx('O,));wMBCCaGazPߝ}mE0 ^`1{o޼yџ|-ܢGހlc5vj]Oh6!@1vTshhh^իGe˖o?~xn؃ŒB?甡RoyYzuss!CVX1mڴ{,55m|B='h`ZC8{lIIɽ޻b 1hРm۶%''_{zWң;~1!hdb^n]=AѣG䴷'$$$'';v֬Y.R"k>|b6mbԩ]w0'ѷo_y7N6f[zgwv @u2PPhw}ʕxGĉ-Zp8Ο?/t[hU62^x8ydBHnnKٺw|J҇Dس Z~=ڵߵqeRC@ +ajnn...>x𠖃sM<¯fe3xe6+PP B*ՔN DQf3LAAA)~$P :|e(aZȳJVXiPYR? *wm  0&DPs?عJ{y`>}zMMMTTyWUU}^oIIx, f*ߖ}!)<^҅Z+@A#(4UKv  }jZ6f4 SN1 eddq/_޷o_Y>}@ Fܹs7tۃQӎ||Y棩<[ڛfvb~gs޽s 0SG@Tt&tZVfү_͛7o;X- Wj`ժU={ܸqA)^E“~8r!VAmNz]cc@q! * h{r񴴴 l۶ws!F~}_g8m%6G3ʙgP1vip 9,,,99ZLLbinnPk:s|\[V36yr$%OHwн{wl5dȐn>5EM"8\___.`у{b7%؆SN Ϗ=x䀀::FPJH;p19< :p/EEE/_nnn?>{N6gGX ,'I?.b v Jqeu@)_0^i4@Z#_ RtX !.VGJ2<tgzMAv$!N!az3:)S:&U'%&YƊYn ń-s2 J͔v^ 7uHIc* AUÙ?Pf3_-[v5d7~,DH%@`%!j$_Lki!iKI9((hɷ~c uFhLԤ(T²'HOAw{kNJ'|HIEd2bq]J Gp^_WNr{xNX~*fI@h&$H"#.7w9 AN Xgp YI P z \6؀(0P_ IS'6n]Jw!CL2%<<͝:u*!رcǏZ@$h8@0 mނ p(/+H~~~}}q ^:Li10P *҆.yM $22"L B(ON;w2eJHHHVVV߾}ݽQZ !@άŮ10q"!!  }:Y”?h|ɹs6o޼vZ(E؁BJO=Sa "h 㧜+VxW+++|ͣGX"I1@!`#J:Z$i"IJk?M/_nZ}K.*rz@`ʔ錛jt=LZ87+a'ONgKKKMMM}}OUUn\%fBzi@_BLDAZ+c(pz(KHf/yCLi ]1^{hE G v;{t aG-T1XEs5B f617|yʍ7C9(`(pRZFJ4-m (37ٳg͍ڳtBgD(^MLh3+A ̸qO;w.:/c}4VB2`p<+u @f_fΜٻwoM敠< }.5RXwPjh.#(US Q @xOSd)=UoeG ©/`9V&F^ ,) +{uIȘ2R!|n춴:G;؎ P% _zPFH7J[-NU 8+sQQQ{{;{8S9^`R !~@,`:Y(>}:#[[=M(-#U32Z[n+o )ןēUp=`" reK#*0rdr*ƣ5XQQQ~G=9  A1+ߕ,ЀJK@ب{4exSe9V 9ً Ja/|jR=0| \n4/}c%)722p]ZC"V֬Jn/@=XL&w˽.LƏb3$eZ(D9&}hۅx꫼J6t~ V bZH _t[4VwvM?M|Rձ>y[/6`9p1Twbbve-,̀\l05j„ G5k!lyyyܿE| (ce7#!Z0u)!!!++=>rVJK)@: TLm)%ZCIcU\\l2BBBΑ@V'cgqvLs (9A⠱?ZZZWWWUVVן={ǵs4QhAa!'`T &Ϗr{] @yy9!ŋ\2S@HFx@5}4 v -$$:&p P6KJJ֮][o5556vP(&PEH=<<|hc! 4 f} 0?~ӟV\lӧ6C%0J &vi4Ji%!Jtu$rhC GQ$HiU4% $/ ^LBBG=(ApA8tm0%@ BzHsϿ{d: B0;3B"("d4  BB-Qs]Riw>}ț @-H0S)WΦTK+_U(V@kO@]_= @|SLI;7EFB& h)}{>FM;M' 7h:(mƊqƹOS ! @+褧dbe' !V+v X TP3Rs۫hiiX,zjkk~rM@oKִ-;'*MkkB444GGGwMPq R,#ۯ}tAdZ↫k+Yv~D)%Z)))ٳ_II LXŔy/e`S6ƪnpܹQ]Gt>NV Ү|O?oݻ/ҥKn]m}J~umqXemEgЊ<&<|V;/v!Z<im6uʦF{_XWR U,$&2''֭^vɽc~';;>000&&fӦ/ =\6V d8~p8s>ՅZWa k;&jh;9Zl Rʞj- WUUSNjkk/_lX 5MnXV&)UUUmmm|4VrIyyn涵Y,/jUۭV+9aR^^` ;::***Q !3c:۷ؿ?WlٲżE~Ẻ:kUvvŋWXnٲ%22r͚5Aw:֭{W%v*33sҥ=|ܹo޼Yz+l/oދٴioeNs=v'NhVJMM_º&Nxdʔ)|MMMo}>LcW`!{5LK,ُEBRSS;~ ==}˖-kmmp-[L0!99oau׭[ws疔0[#466_@R%,{X<̶m[NVܡCm6[VV+tFC?g̘1NbgϞݹs-ZĶo߾{gÆ O<4J\g=<---55500&466DDD\|P{祗^}Qñ~=z,Y^;Ξ1ck/]h7͘1#33.22?O^^ԩSgϞ={'|矟6mnvlaÆEGGN0aذaV5>>~رݺu+++233sss?l􀀀>}XBCC+Wܹܹs'MDyx ::W^۴ .;Ʈ]nt8ÇOLL*--;vƍ 6gΜ۷mdQQQ#F-,,OLLܴiҥKNx⪪wrK^Ξ=kX95hР޽{'%%;wn@@ljjJLLLIIkf̘QSSp8ڏ?ʀOp{kҤIǏg/5Nŋo}ݬ>y1c y$o%hQQQsmv5״2 555W\y_uәe˖j͡C3~cǎQJ/]e˖_&MB6xsssuuuJJʳ>_@)u8׿l6`y 0?dyyy… ###F6(V۶mc֯_7))))))/?x5\s뭷&''k˗?111.]666677b۫m/777V*}{7n8a„naƌ'xbO<+innnllr矦Äa 6TUU Yw}׫Wz^_4i"=:f̘xw5&N|r-X@i.1;::7n8yoٲEϞJ~}|a^^vv6_8=G|!9rHzzzSSzw&%%㑔+Ȱ|b &AݷoݻKKK2(~GV?nooOJJ5kˠԈ.[YÆov׮]=zo 0p 9R裏#""ׯ_ˠF~d[:f-/?*}!ga.\8qbBBByy9?L2\(ށ&N0`)S+_ePQ> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 501 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 500 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 15913>> stream x}y\Gp) "'Wbb4j6k6&1J6jI5! DE#[/ef~(g4y~[O=,pF󄄄,[,''o6mp#/q g&i(k֬y=<<gϞ& DxBY$&&rmcc3rH___GGI&){3p <ϣ DPB\4+aÆy{{zzzzxx1bĈ ,xs-&#GVUU^LJE?Ą#BACCի&aACJbz `L3@JO8$o)%3I(\/8" "汅PMRL8R^J*\p¼UJ:JBfdR{{{7oܶmZjLLwAD&@Hʋ/~:.f{HC"z>{ׯ_y~Ν7o$EBJ<,ceee%%%rJWWWRRA !! KII9w\JJ ^x!mL&@:u9&&&999..R灠h~CY/^ ѣ:::fϞ#,A:?JxqT@K/ Æ svvFK{;\<)(&1 XCVϚ51+Ư7o655m޼Y(aV9rdD%f42w-**jii 5fB)(N ϟpss n(\B)O<wys3 ĉm' qג A藞۶m_kl_yZ#P#Jtp AA(0+WV{{{K2PTTRvvv8PJZi/%fcjȬxq-@2foKԌXt"l^4rŊ^^^(ZF)C' `0L(yLJꫯ&$$~C"aD:*ٔTs8TCƗo1pEf¾8wuuUUU}ľ.QDaMb fXfb˪Gr(B*Jaccj0PQvv޽{j](DmJFhɾb! $NJJ 'O$$a $qUھ};w <<ώ|R!B ֥666ݻ ëz{{KJJ5gbR(nlE ;{lEEŋ.%$3gx !q Vq܅ "##KJJ.^XSSR#K@1 ERP{'0 !!!#FP>>>K" B f'm=c3fhjjzG/˄둂y~„  XxqssҥK`lؖ!%`/4hJ EVnϘ1D6bюTꂶ;zF#ZH&» 23gz8 PI&9rUBiL~P^UdhIG8:YI(绻t:ˡsEK{h *3 mR^Zą )-n҆˰cD !Cak֭{7I'A4QEA őUg&12ʂA)ׯ_~z],Z`qdz3X.T~X 9":x/øe'$a=@h1>АS"1!1 &dۙ[H4n\H%RM~]~8w„ D-&aS֜<}[ cfEP \***N< 555'NBfD^#?=LڒgΜ)++ݲC/D (C.~fPw^Juĉz77 8;FFFZިQ8s͛m)=o޼ww1,,m+#~CC"͜YӃTl~q1Ez86&G}w "00`0<555##> ̴gee 0`رqpa]f8PL;wUVUWWϟ?_QK֌P3y#/P"cG^^oѣKOwc="J*`BmYE\p! c!"Kt@ Ə^H5!JY(ys%d`L+(*g"$&B LK{qRPL9(>$8se⚨NGZD[!?a 'ުfB P- L! 7 ŌV2P>hĉT Cf<#FKjF xC^]ZP4LaS#EMy(?Çn s긁"ƞ7~z &bkqd-|ס ngdd|mmmqqq}FQpD L jW_}uYiQ\d .9=/i(&mݺ5##e֭OtR.' m!}ԩ* i|wMLLlllLJJ:q$ʠLMahlLwWUU8ta1x,:{lmmÇ+++###Qtt4j莌DH(+B;n8^qvv2es='B8VTSV!㸞77aÆ 0qܸq'x;9f8'Qk+WD >-JL fŔ"~;::8Yp3}9,_,].ehB(_,RTƸ8;I(P-5 4a41/Bxrt:][ZZj5=!1׉[Jٙzj#b')|7LH.EBŋnT)$,,IJl: ?,))GGp&0E_C&TН$&TcׯpfCB)j/^R!.ތ%r6OmIANHi zzzzzzpR HJJRTt癭(>kJdƏIf"f9ԁo4zk@Fyyy?CwwwQQQxx8q3P_kO"&T~ڵ(^օL4yL\ )~s@/޽qw}օ2RQ\^*PFl 臭g^,Ydgg3 Wƒ(Vzzz=l2OOXF㏃~D,' ~ș䌏/,,lhhX|yllUttt``ٳyùYPٯgGc@F,9s^ bܹ< mfYb`Jegg7|kkkXtippT"'A33ՇU:Wcmmp‘#G*J}YC 8QLT;Ψxg9{>}:hF͜ /bo' _& (QF:,, .E"-4)dffFDڿxK2/1ٷysVgfy0wrvСЯ,G6;Y:tCee9s[[[\Y̫Ցfq@`GSD8~|-VP;$/kÉ;;;Gb=zܯ_?rY.5 ly G[CS,WDEY$!9.yAYӂhDKpK !Ydf3w#)ه &PR6dK& N,mK$QDu1x]9,qZL3#.f33ܹs<ϧO,iGC1LKDwzQGH ӑR) /_!8n޽/_>x`bb"TWW\Ä#+4}ˉ*r#ó |*K|J$''ڵn߾}ƃ r&"?iyᙒk[Έuх]]]C-,,llltuu " p=>n f@E}"Z.--C& OskGBC8_4H555Sno``e垾 3q...%M555 OmR''' 2Iyn(Z$Uyyo[oqN,[L8%\˔ Γ3&LbwO?Wm8$aoA[[!3C2q"Ʒ B ]?~y;?QE}CX'N(t` ]QQQut?2cLZQ iZybŰ_͈X@!߿o -D&;}T*դI ƶd)EV#RN<ǧ]%Z X+/[z{6T*H.gJ(@7M`(~2&$|5MHNNNMn{twN4KJY___RR2o< S(!!'WSMqkXPa#GQ!;5nZ ݒL^y< ٵO7NaGduT*L֖xt00=FA<#T8`#uC:8Ƅa0D冁:fׯ~ DRXGs:S⼼qO$Vmodz6 TFb5B2)ZfLaKGh f=~0lCC}ڋ6h1+)P\*%[,X't-"bGޞePf*Ww?,؂ĎyZuss^p!{T;khQr2 \j ڬ[ Jb3RbC,X=Sk }‘IHeL܂ *.RJv\} a655W)rk2'E7UUg _]pWUU iii)|aF(T(pgܽ!)#""**BhOj`疖lOAb!qoU{mmm mmm_~qǿa7ٯ.-$r7swݪ*G[u<l`#&lAEׯ_7o^NNN]]ݴi^xW_}Ux+@|ֲΕ~ OX$;d!nBʊP.#$A/l z{{DdbuI866h)ӢPC1iAoZGP T77quN` !$a:)(%ʛ7o>o3fLyy m81p /yyyG~'{zzg͚EC԰b677gee7nO>dAA%K8*x<&UX% H4ӟx1Jg(=](d PDt5}Pa6mD9^TPx* E^= @IuJqgMc(?# gSq=1_$`JF WnR39P dfYa9_epp492& 0 RΌO (>wm۶ et)P]jwBXY N&y(]2]R,Y +M) @lDP2MHA{?ÒCI2SR899i4̔Cte^(e tTAyǻtfOsabбC Ij|Miiɳv,R0`СMMMeϞ='N9uٳ_>p@CapA̞ӊ,EО={:::ƍk׮qqqZv…xDÁS~ʕ+UUU=ܮ]z1cN>0}t9X-xe"ٳgsWSS>n8j O?M"D1%$e(**rppT(AAA={6ϜsDCRPۛl2V>x!C̚5i)\0rFU^^aÆ4]3=qg-͞BLsJ1H1K{ldKB(} 8ؙiGQQYY>ӓ^6x]riK'q68*%yjrC-:KZfxdvvvcǎqA <@9O^"cKHA\*YEх 㟳3hv:DIZXS(D¾ 6΃sMwN~ԤѨdqtsD ׯ4e(eNNԩSMbK%K-ڔ f `o]\ `~d[91?\pass >oO,+?S^zk֬q\q|c_a0 ?| @)\]]z{{N+**N<|MMMDDp3HJ/JQ#ޜ8O>LL.]D"*---۷o>}1_vg/ Yptt 9r$x5kVUUFquuԡmGLjF~D~} A=dhBO<ή g&I٢ NSVTTttt\>cٲe...톴HAxܔxsz׮Օe # sf _vQ_Ο??bĈL()ap[?^|9-#<8q ׯ_Xf g@%r@yOώ͛_ IS8x(2p :ejNn_.7=2Ez}ϱ:y'suwi%夓c?gpBAA9{옘Ϗg:WĽ{Ux7azd^1萩#|LeIN;&!*SN{u)=5XA+o]z2'ecYx̞LV6>BPP:ӖEL8@x-Be@brPq<9t@)NJq()yb C@ѯ_=J.#afHdBxޤ2J<+5=PI~LtaYd@/G_*FV,#H9.&T{c0/sAn' vx9J꯸ۦ)q͝;wРAh޼yǥΘ1XDLA_qV&*))imm *//Sn^nyU%( 1e)~{(66vܹyyy#F)1Ϥި/3:Ғ˗/ 9q@RT`︟FLAۅp9;k׮m۶544|g׮]ҏկڽؑr` `עYGݹsg[[ۻkE@p։[f) ]+Zj0:;;[[[{{{#TtoqzQxgCqkO3zTk-H XE/jogGydݺuz?8j4dw$,<rkDt8iDDd(**rq0Q"1&sã`gs4nԹ3AAA|r;`om=3}K .'vj4L;|kBTRP>W^{)ݗ4+zRtPDf {;M¬?dvuut:T#?"c;KńgKe4ɓ'[YYǗpa1~#cCC߸{ t nϞ}2y+ 2} ,.PqH8N$%;k֭ trrG/⁤T&4@5bKN&#7ԜfBA)ɀ2qgLv9r˅X4ek$*sTǕ "!!!66vҥ GZ S!?:TKS ,[='\h3 qH`nw2Р ;K%3]2# :ywq]w궃'O9s)S/^qkkk'LP\\' `/[D}]ٞv}}}{{O^^z9dWxw.DvWVV*  3vv-Cf'%վ\Ȁ^ś؜5AT*oٱcGAAAMMMTTv38{O Dvo|⃝%bk5-YI/ -,, h71[HLo+A&֒E< q0ܯj@ƃQJT&4b:Qg'Lpg *c3HtFZS&.# PNJ5tPV{}E@8!ZvuumT5}a MUUU666UUUbIs px)BSۛ7oرҥKW\KKKNuZZRo*E1 Ң\\e;Ռǒߙcǎof:+--  Fmca!/Ji3g@b"σ=NƬ,GG7|s<[o8`LHg8fdvҵ=S\\|1SU\w7W:@jKFXPYYʡ\)VhhFY~ѣGlbgggzIΟKYYY=S<Ͽ߳gOgg'5O ߷o_HHȨQ~^z?x3\ROַOtzyy quFR'܉'ucccww7yRSSR5۫Rx񭭭GccVK I?wOա'***j*ݻ]]]B6^|ss3΃N===߸qCR\\n u/_CUUU͝;o}ǎWF*І \8E#"8ҥK b?zYqqqqvvvyyyicǎmmm-++۲e zS;wbbbfΜpqT.<<Ν;˗/Bb$$$,]4!!FKXc۷o;OF?HHH5 oF[qW^tyyy1z;wMַΎ=sڵkѱFFFnذ:/&-**tZfMFF*OIIEi42''rᡟ?𩧞zW_z%T#"" ~_h@AAE>O>>#wYhQnn?ϛ7oɒ%K,y뭷6n8cǺ:::>SmmmΝt~~~3gkkk 8p`mmYrsst:777;;t;;Ç3 0k֬{9::s8nӦM7n|]]]MϯcǎؿEEœO>9x`^?a___(??e˖̙3YB?诋ĉ[[[}}}=oΛ7/===44駟4hO<1tlJ2f̘aÆ C{{ottԩS-ZܬOO?Ś3gQyFFFhh(i0BCCϜ9/oCuN81mڴcj4Ϝ9w^t/mmm111.]6moƛm۶N8? fdd۷o$666==}ʕy+&&&=='((ԩS5eʔ[nZ>SNBl?|QQp޽۷o߾`0455=cU 6$ی3RSSy/--̙C~A;::}]V{ر_ <^ W^bŨQ;TX\\/>Frh442Rg"Xhllvڴi^~対J@j;w$?j*bFEE\2&&FJLZu1ֶط.2:/$''߹sg_:?; `JEq.\4hPuuO?pP"^; 63?cwwŋG~()6`0Hm2{SN?~Ȑ!%%%ǏG`xu()XKK?PPPaoopPRnv r ҥK^w^> rD΂ 󃃃}||Qrt2 ABQF͝;XQ=LE&3Vsss\\ܨQ{9zၠh獎= endstream endobj 502 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 162>> stream x1 aK&> 2K:%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%jZ%j _9R endstream endobj 503 0 obj << /Type /XObject /Subtype /Image /Width 150 /Height 150 /SMask 502 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 150 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 15913>> stream x}y\Gȡ(F<AE+Fc$?͹dͽF(jNC0$**1x((\ r_!7 LS]U3}o=ST]j_߽{d2LK.]vmzz;~#G< #gL6'""bҥo;vƍ }ݳg8"pf"0>>Æ 6lܹs6A*:~`# (A3i3=@=B_|ʹ4wyuQ_t+#.B)ZZZ:::ݻJJJ~駋/vuu]|ѣ qe[ZwUFFF޾}OMMs1#d It'N455ǧ$&&@\\Z6y(^zܹsп9rdXXXGGnj3=HB /N[JheO>ށNNNcǎussCK{;\<)(&1 <>>>f靝̥ Uleee]~Jys5Zf E)# D]aF Áe xU(P JSÙ3gBBB<==9,C۲ ׃PʺǏoذ6yk(?߷Jhk˄ KOm۶=y(‘G_p{ŋkz(A*zHA);;;  _NWY8PM1pdϝ[<P7lX [@RꅻcaW }@E{/J裏hIANlff-01i(Eff /poH$l\HGe2=:jj1bl|y( 'ZT)yh[l;ׯ_WWWee%[싞B <eqɘaNL<i[ E2\VE=CRP {{{Ʉnݺwޮ.Fk.J>QvDZbXH`B!/_e4?EHI!#$ī};w@TTTUUu|)>BKA)rrrݻwgggGEEUVV1kĤQLs#hA9ty銊s@IIy$3gx !q VqٳgbbbJJJΝ;W]] W#K@1 ERP tvv><>>>&)""bذa& `S2~sB(줍Q L:B<  3J#qhѢ%Ktuudf-CJTií_ J9p@Zaĺj*ԩS{zz@Dl3!H.hgK/|aa$LnBy(AML6 Μ9דġ8lG_H*PL0СCt"Z'.hLf򺖯"EKB?J@qqqǡ|0}'"JhnSHJAYJ(7$/b$eeeSNEsҥܮ.h1 儠R6H{쉍jᩩFQ#1,P{;sBl?㧟~:h \C JQVq/\뻻K{XBwb8ˉ\qƍ=F1 `߸F _x^ yw֬Y9994yӥP91p&2---""^C?S=Odʢr$B<}vuuEEE}TOk)#"=i("ă -!#J5DNM|5bd& Rnܸqƍ44ɱdgg(\4"orDt5bS 'øe'$aChӐS"1!1 &dۙH4nZH%RM~oʜ]?kܸqD-&aMz~F?W(J_˛;-::.V;::<<JP(&i…+#>O|fT?zh///___779s80̉.3L(&Baa;w4ͪU̙#-CBkF(ҙ׼ѧ~Z(#p//\Qĥ;ñ^i0lAΞ=B?}E(%6C}RMWlJi +%hlbJJAę3ɠIEuFjf1Se$aN9T2qMT#f-"I\Э0BoU3p(bF+(|0~_T!3MPN%5#|!f.x-y(f`k0̩䑇ݦ7ɌR"vPT ggg6z}aaaTTq3P_kO"#M*rJllhEB&<&oEyQQq| ZH%GRm J77z`+ٳh4ŋ_|'^V =Aq(:FFFvww;K.MHHj .+F!XN\摳șTPPP__lٲ;;3f6s >ѤRUTTKR5JkxK$K,u={^!V OejCBOCَlu2I9dgggJ5sLf֋b;MU\z%Q~]Խz=!xP`()GEQ/ZL6<I#`ha /ʀ(+𾃄"$eU455-[8(kZp@-YbzE /j0#q>}n %eCd0 MMMѶDETcGޕw4s8BjfCɴnׅv@Z9%f(3 uuuEL7oDǏ?8pu)=oh|Aqd䓚DVUSS#ܼy=]`F4*ɗ/ggpj…3f -$/[lȐ!&Lw ;ZyQ>F&mƓy -@YPPܻwo{{{```zzzvvOX/7Wi 9x"a*W: d")ǎ&0[Dr^\T0a v%(h[oY2a]]]IIٳ6IYJV"nʯq٦8@) f0#e5vF%1$' 8%Y0:{_-//G_~&##q|0v1"#&Z`6 q\Jo6{BɜHb&0&O#F(++۽{,j]lI+Hϟed"~ZMyZ۞tZr7tv#Ϳl ȐR1GDE⃝Y rҫ6@Twٶmۖ-[lَa,d`F.J2fR# Zo޼rN=tHaT4n8+kjj^{mQNyG'%\j[nݺu(Y$W7"U.`ai5Y?pwo)V hER=> ,9:t1y,CxS_lSPIBҫ Acl I OĚIwָOsKf V%#9kBc0SJ9z,때ʵ&OB0wgT5N?3, cg]$VVuJn΢TIܓaSRJJӦL5`9*-6zєp ,}\XeU\9,]]!w@.bʑ$4`ݻY]zH%M+j`QcaåRill,//2eJsssqqqhh(5,3iNKP2]]TVVj4߼yϏ) (e!5lnƗ҂Haaa|IĀuYC ~s)W`"H*2w5yB_~YZZo>}:77wӦMUUUf>ɷg{|j^[5ѾB|`>>ܵkWlll]]ݶm`u--YwCqD*g .R +vttzt*ӧW\5tPooa  EEʪh׊ dЮ*..׷ ?ع9;9@ 1tqkU&^__֦j]]]//fK_ZZZ8+**9| ޟ4mbGL؂祋fϞ}ɓ'_%q:ֹ/b#V)I8C/q+ 0LvvvrBF4o#>MP ROO;1OlrfČ!-a='xV2- :sm B)h>|PYbn1hy*EFl⾡tzk :RRRR ///22LH 秫0AlnXBt.U)E TWW;w0&uOP; r-[z{{={v ހ@3 }1/ }'''gћ6m8qɓ'GETфa #agt_ʙ ]766Ɯ<':;;}||f*ExD J.8NRTׯ/\0##cԨQ+B3 -oxNTܑ#G>MMMAAAӧO'Ij~1p nj3`Gy$??Ş}A<Rz*l$O%3.ANF( :iX(0qDN* <yVT"Jd:%IK߃RиMrApGT|y XU[(23~288ϊmKBTcHQg'BryO?5kֶmۄ2Ɣ@.5D!,êT'd<.Hl[./B)/^ 6ym|YNm&ĠaIA! $tN/B)\]]ZpfJAA CNNΏ? &XJd_~Q^?K}2n.LL\:vHA1i߾}*J}WRl6Z'/̑mP2ٳG׏?>>>ĉ3fHKK0`zP"\)K@gϞ1cڵkΜ9/rbbN7o4ap (x[*++z]vQF&3f8}̘1&IӅ)L ׷SP 4hƌo|#枞˗//]Tӵ4hӧO DZbv ib@oڴ)>>M aaiOY vӜR R̼Ҟ8(PJj_B('vdڢac~UtttTd-b 򬐃7O[: Q-S[ h;Yzz'D %#tttTTGqA <@9O^"So_`vgy S$25|m`>{lRSn]gh>@lU(D¾ 6΃sMwյ7[. :Tx|'0kfnӔ Woߞ4i],ۮ¿$<"@a&hU6ZOcBkJ9o޼&www|XN3Uh +VL*4[+P 7o VTT?~h`g"UrK-9¯baoNLLyɓt+Y.ܥ|A$|llpL&E|Ge d2Oػwӧ333RfRE777OOO0rH z0%"7ӴD  E:~ĉΎ%%%7x`&80I塔+V~[XtiOO;eD^Mg%8ڵ ]@aa-a6F BdRhU_̙3Æ 4hȄEPʴ4kׂx TPPsvRR!51)b?>X`0A{r\5I/s[^"jo|9ЩqN˵Ic3Av1QrثKOX\}n˪?s].:.J _B @L[1xRIyr\4R4PR4&Yܽ{Wٷo߈˗ '&HWf"/5]Tb!q(aDQ0&TfNX".R`;q?tw6uT`; =d 帀6SIŽ4ٞHNj8B*L(OD  q_Kcƌ5kJ]]]aaٳ9zԩSE幹oF^X1\mbVBURRV^^'ܜJ(zVWO ,/CD frvv6l^iT K]VVWXlTbrqح+~UQyzd2>ZD^u}]fS_ԽawZFజ:cHB-,`NI~XN0k]]N} HqQ҈fC Ik/7ԜfB%:BR^f4 0ڲ݄v^cG_,afw (N6-88xѢEǵԌ7 Po-˧X>cd!4,2d]Bwkյi"\!^Q\N`gq JR(ƍK/MQEń3\q֭TgggR _}Վ;󫫫cccp/DG޲<2iQe㸝;wn޼믿,{0y0-g}aÆ2bHB'Y^KYJ8]+ѱ!:֭[vvv惝{%L< 9,vM0Z㪪93r BĮB﵄2⃰ZeeS{{ǽ) !ֈ6Edi^Z$R PΝ;/"Rݻn`7o#$ToJc>ުt>$1]8ph4gjSR6n)ѧ$#GN֙3g.^Hʘyb8t{y)JYZZzΝ]vJ%Z`$}%햯dK.: xdm޶yNFÃǐP59}F|[0698e~s8//jUnS,,IYki~I4OrS(h@шmptFBKFq0tPfZ]{%@ , GnhYuCY{i3WV~$_Ml@I)Ðx9l10F7pP`އj_8ٴcV+YJtr6$(U@O؋ҁ$qpx!+KTo_;*x1M=[7h*on &uB}ʘ .-LgZZZ**HeeڎybGp_QC٩V ~+R! F}>>츓^3Dh4zãvbRXf܍sR_mo?E5%E*+++++* sp].ܙXEK)Ʋ.D$O믯_cǎ_x/--8.in~8PJ >9Y!>Ľ)1/>r$; ;:SRR"""vQPPW_m߾`0曥…zwph((o"?0yr2σt%% ...ʜ9s|W_}544YbOrb=vXJ m'N(YWnJl.:Td,ݰaVݸqÇl8rHA-__~trrڳgOgg'zO ?ܷo_DDĈ#~gy %w޵ZmyyZnkk+++߬onn&ގ7 uuu uuVV7܉7uCC^7/juyyV8{zzj5/~5hhhtxd8Z@:NVuuu Uz}[[/~} AT[[k0:N=Q.| !^g}… h\ۖ-[T*sݺu=\KK ~?Ƈ*??Æ v  w^B؛L?n+o6|S;vzw:͛V:x о}<==>뇩Yo߿ڵkn ur֬Yx;vXf T6mE)zf qqϟW(7nQybbիWsssU*=l˖-藪ܹ?mڴGQQQwYlYee%… K,p?j?@GNÒɓ'[.\1Lh+ҥK!77?DP.]s玝ɓo]ߺu+!!ԩS֭C@RRʕ+cbb6m_c𯅅k׮D婩NNN555:V[VVZ]]]^^./_^xgPh>'Oxkm6Ǘ3gΠ p7o^ff}6n܈JWXO?<v TWW q%Zi+W|G&MՅV^]XX755ܽ{w۷o7L%%%񍍍 ,@!<==NzUKKKۙ3g wqqqoN;rȯJGFcbb~k0p5k<#FoPaqqO?zA!Z-fxokk>y$)::Zj໻F#^> endobj 505 0 obj << /Length 20242 >> stream 0.271 0.267 0.267 rg q 15.000 45.196 577.500 731.804 re W n 0.271 0.267 0.267 rg BT 26.250 750.278 Td /F4 12.0 Tf [(Competing Interests)] TJ ET BT 26.250 730.324 Td /F1 9.8 Tf [(All of the authors have no competing financial, personal, or professional interests that have influenced this paper.)] TJ ET BT 26.250 693.722 Td /F4 12.0 Tf [(References)] TJ ET BT 26.250 666.267 Td /F1 9.8 Tf [(1.)] TJ ET BT 38.132 666.267 Td /F1 9.8 Tf [(US Centers for Disease Control and Prevention \(Accessed 20 October, 2009\) 2009 H1N1 In?uenza Vaccine Supply Status )] TJ ET BT 26.250 654.363 Td /F1 9.8 Tf [(http://www.cdc.gov/h1n1flu/vaccination/updates/101609.htm)] TJ ET BT 26.250 634.958 Td /F1 9.8 Tf [(2.)] TJ ET BT 38.132 634.958 Td /F1 9.8 Tf [(US Centers for Disease Control and Prevention \(Accessed 20 October, 2009\) CDC joint brie?ng with NIH & FDA on 2009 )] TJ ET BT 26.250 623.053 Td /F1 9.8 Tf [(H1N1 In?uenza, August 21, 2009, 12:00 p.m. http://www.cdc.gov/ media/transcripts/2009/t090821.htm)] TJ ET BT 26.250 603.648 Td /F1 9.8 Tf [(3.)] TJ ET BT 38.132 603.648 Td /F1 9.8 Tf [(Robinson R \(2009\). Personal communication.)] TJ ET BT 26.250 584.244 Td /F1 9.8 Tf [(4.)] TJ ET BT 38.132 584.244 Td /F1 9.8 Tf [(National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention \(Accessed 20 )] TJ ET BT 26.250 572.339 Td /F1 9.8 Tf [(October 2009\) Use of in?uenza A \(H1N1\) 2009 monovalent vaccine. http://www.cdc. )] TJ ET BT 26.250 560.434 Td /F1 9.8 Tf [(gov/mmwr/preview/mmwrhtml/rr58e0821a1.htm)] TJ ET BT 26.250 541.029 Td /F1 9.8 Tf [(5.)] TJ ET BT 38.132 541.029 Td /F1 9.8 Tf [(Monto A, Davenport F, Napier J, Francis T \(1969\) E?ect of vaccination of a school-age population upon the course of an A2-)] TJ ET BT 26.250 529.125 Td /F1 9.8 Tf [(Hong Kong in?uenza epidemic. Bull World Health Organ 41: 537542.)] TJ ET BT 26.250 509.720 Td /F1 9.8 Tf [(6.)] TJ ET BT 38.132 509.720 Td /F1 9.8 Tf [(Taber L, Paredes A, Glezen W, Couch R \(1981\) Infection with in?uenza A/Victoria virus in Houston families, 1976. J Hyg )] TJ ET BT 26.250 497.815 Td /F1 9.8 Tf [(\(Lond\) 86: 30313.)] TJ ET BT 26.250 478.410 Td /F1 9.8 Tf [(7.)] TJ ET BT 38.132 478.410 Td /F1 9.8 Tf [(Longini IM Jr, Koopman JS, Monto AS, Fox JP \(1982\) Estimating household and community transmission parameters for )] TJ ET BT 26.250 466.506 Td /F1 9.8 Tf [(in?uenza. Am J Epidemiol 115: 736751.)] TJ ET BT 26.250 447.101 Td /F1 9.8 Tf [(8.)] TJ ET BT 38.132 447.101 Td /F1 9.8 Tf [(Fox JP, Hall CE, Cooney MK, Foy HM \(1982\) In?uenzavirus infections in Seattle families, 1975-1979: I. Study design, )] TJ ET BT 26.250 435.196 Td /F1 9.8 Tf [(methods, and the occurrence of infections by age and time. Am J Epidemiol 116: 212227.)] TJ ET BT 26.250 415.791 Td /F1 9.8 Tf [(9.)] TJ ET BT 38.132 415.791 Td /F1 9.8 Tf [(Monto AS, Koopman JS, Longini IM Jr \(1985\) Tecumseh study of illness: XIII. In?uenza infection and disease, 1976-1981. )] TJ ET BT 26.250 403.887 Td /F1 9.8 Tf [(Am J Epidemiol 121: 811822.)] TJ ET BT 26.250 384.482 Td /F1 9.8 Tf [(10.)] TJ ET BT 43.553 384.482 Td /F1 9.8 Tf [(Reichert TA, Sugaya N, Fedson DS, Glezen WP, Simonsen L, et al. \(2001\) The Japanese experience with vaccinating )] TJ ET BT 26.250 372.577 Td /F1 9.8 Tf [(schoolchildren against in?uenza. N Engl J Med 344: 889896.)] TJ ET BT 26.250 353.172 Td /F1 9.8 Tf [(11.)] TJ ET BT 43.553 353.172 Td /F1 9.8 Tf [(Bansal, Shweta; Pourbohloul, Babak; Hupert, Nathaniel; Grenfell, Bryan; Meyers, Lauren Ancel. The Shifting Demographic )] TJ ET BT 26.250 341.268 Td /F1 9.8 Tf [(Landscape of Influenza [Internet]. Version 41. PLoS Currents: Influenza. 2009 Sep 30 [revised 2009 Oct 5]:RRN1047. )] TJ ET BT 26.250 329.363 Td /F1 9.8 Tf [(http://knol.google.com/k/shweta-bansal/the-shifting-demographic-landscape-of/tkwn3sjme3vo/1)] TJ ET BT 26.250 309.958 Td /F1 9.8 Tf [(12.)] TJ ET BT 43.553 309.958 Td /F1 9.8 Tf [(Medlock J, Galvani AP \(2009\) Optimizing in?uenza vaccine distribution. Science 325: 17051708.)] TJ ET BT 26.250 290.553 Td /F1 9.8 Tf [(13.)] TJ ET BT 43.553 290.553 Td /F1 9.8 Tf [(Presanis, Anne M; Lipsitch, Marc; Daniela De Angelis; New York City Department of Health and Mental Hygiene, Swine Flu )] TJ ET BT 26.250 278.649 Td /F1 9.8 Tf [(Investigation Team,; Hagy, Angie; Reed, Carrie; Riley, Steven; Cooper, Ben; Biedrzycki, Paul; Finelli, Lyn; Jade. The severity of )] TJ ET BT 26.250 266.744 Td /F1 9.8 Tf [(pandemic H1N1 influenza in the United States, April July 2009 [Internet]. Version 38. PLoS Currents: Influenza. 2009 Sep 25 )] TJ ET BT 26.250 254.839 Td /F1 9.8 Tf [([revised 2009 Nov 18]:RRN1042. http://knol.google.com/k/anne-m-presanis/the-severity-of-pandemic-h1n1-)] TJ ET BT 26.250 242.934 Td /F1 9.8 Tf [(influenza/agr0htar1u6r/16)] TJ ET BT 26.250 223.530 Td /F1 9.8 Tf [(14.)] TJ ET BT 43.553 223.530 Td /F1 9.8 Tf [(Novel Swine-Origin In?uenza A \(H1N1\) Virus Investigation Team \(2009\) Emergence of a novel swine-origin in?uenza A )] TJ ET BT 26.250 211.625 Td /F1 9.8 Tf [(\(H1N1\) virus in humans. N Engl J Med 360: 2605.)] TJ ET BT 26.250 192.220 Td /F1 9.8 Tf [(15.)] TJ ET BT 43.553 192.220 Td /F1 9.8 Tf [(Shinde V, Bridges CB, Uyeki TM, Shu B, Balish A, et al. \(2009\) Triple-reassortant swine in?uenza A \(H1\) in humans in the )] TJ ET BT 26.250 180.315 Td /F1 9.8 Tf [(United States, 20052009. N Engl J Med 360: 26162125.)] TJ ET BT 26.250 160.911 Td /F1 9.8 Tf [(16.)] TJ ET BT 43.553 160.911 Td /F1 9.8 Tf [(US Centers for Disease Control and Prevention \(Accessed 20 October, 2009\) ACIP Presentation Slides: Special July 2009 )] TJ ET BT 26.250 149.006 Td /F1 9.8 Tf [(Meeting. \(A Klimov: Virology and immunology update, K Neuzil & A Fiore: ACIP in?uenza work group considerations\). http: )] TJ ET BT 26.250 137.101 Td /F1 9.8 Tf [(//www.cdc.gov/vaccines/recs/acip/slides-july09-flu.htm)] TJ ET BT 26.250 117.696 Td /F1 9.8 Tf [(17.)] TJ ET BT 43.553 117.696 Td /F1 9.8 Tf [(Mossong J, Hens N, Jit M, Beutels P, Auranen K, et al. \(2008\) Social contacts and mixing patterns relevant to the spread of )] TJ ET BT 26.250 105.792 Td /F1 9.8 Tf [(infectious diseases. PLoS Med 5: e74.)] TJ ET BT 26.250 86.387 Td /F1 9.8 Tf [(18.)] TJ ET BT 43.553 86.387 Td /F1 9.8 Tf [(Fraser C, Donnelly CA, Cauchemez S, Hanage WP, Van Kerkhove MD, et al. \(2009\) Pandemic potential of a strain of )] TJ ET BT 26.250 74.482 Td /F1 9.8 Tf [(in?uenza A \(H1N1\): Early ?ndings. Science 324: 15571561.)] TJ ET BT 26.250 55.077 Td /F1 9.8 Tf [(19.)] TJ ET BT 43.553 55.077 Td /F1 9.8 Tf [(MIDAS High-Risk Segmentation Group \(2009\). Personal communication \(Diane Wagener\).)] TJ ET Q q 15.000 45.196 577.500 731.804 re W n 0.271 0.267 0.267 rg BT 26.250 750.278 Td /F4 12.0 Tf [(Competing Interests)] TJ ET BT 26.250 730.324 Td /F1 9.8 Tf [(All of the authors have no competing financial, personal, or professional interests that have influenced this paper.)] TJ ET BT 26.250 693.722 Td /F4 12.0 Tf [(References)] TJ ET BT 26.250 666.267 Td /F1 9.8 Tf [(1.)] TJ ET BT 38.132 666.267 Td /F1 9.8 Tf [(US Centers for Disease Control and Prevention \(Accessed 20 October, 2009\) 2009 H1N1 In?uenza Vaccine Supply Status )] TJ ET BT 26.250 654.363 Td /F1 9.8 Tf [(http://www.cdc.gov/h1n1flu/vaccination/updates/101609.htm)] TJ ET BT 26.250 634.958 Td /F1 9.8 Tf [(2.)] TJ ET BT 38.132 634.958 Td /F1 9.8 Tf [(US Centers for Disease Control and Prevention \(Accessed 20 October, 2009\) CDC joint brie?ng with NIH & FDA on 2009 )] TJ ET BT 26.250 623.053 Td /F1 9.8 Tf [(H1N1 In?uenza, August 21, 2009, 12:00 p.m. http://www.cdc.gov/ media/transcripts/2009/t090821.htm)] TJ ET BT 26.250 603.648 Td /F1 9.8 Tf [(3.)] TJ ET BT 38.132 603.648 Td /F1 9.8 Tf [(Robinson R \(2009\). Personal communication.)] TJ ET BT 26.250 584.244 Td /F1 9.8 Tf [(4.)] TJ ET BT 38.132 584.244 Td /F1 9.8 Tf [(National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention \(Accessed 20 )] TJ ET BT 26.250 572.339 Td /F1 9.8 Tf [(October 2009\) Use of in?uenza A \(H1N1\) 2009 monovalent vaccine. http://www.cdc. )] TJ ET BT 26.250 560.434 Td /F1 9.8 Tf [(gov/mmwr/preview/mmwrhtml/rr58e0821a1.htm)] TJ ET BT 26.250 541.029 Td /F1 9.8 Tf [(5.)] TJ ET BT 38.132 541.029 Td /F1 9.8 Tf [(Monto A, Davenport F, Napier J, Francis T \(1969\) E?ect of vaccination of a school-age population upon the course of an A2-)] TJ ET BT 26.250 529.125 Td /F1 9.8 Tf [(Hong Kong in?uenza epidemic. Bull World Health Organ 41: 537542.)] TJ ET BT 26.250 509.720 Td /F1 9.8 Tf [(6.)] TJ ET BT 38.132 509.720 Td /F1 9.8 Tf [(Taber L, Paredes A, Glezen W, Couch R \(1981\) Infection with in?uenza A/Victoria virus in Houston families, 1976. J Hyg )] TJ ET BT 26.250 497.815 Td /F1 9.8 Tf [(\(Lond\) 86: 30313.)] TJ ET BT 26.250 478.410 Td /F1 9.8 Tf [(7.)] TJ ET BT 38.132 478.410 Td /F1 9.8 Tf [(Longini IM Jr, Koopman JS, Monto AS, Fox JP \(1982\) Estimating household and community transmission parameters for )] TJ ET BT 26.250 466.506 Td /F1 9.8 Tf [(in?uenza. Am J Epidemiol 115: 736751.)] TJ ET BT 26.250 447.101 Td /F1 9.8 Tf [(8.)] TJ ET BT 38.132 447.101 Td /F1 9.8 Tf [(Fox JP, Hall CE, Cooney MK, Foy HM \(1982\) In?uenzavirus infections in Seattle families, 1975-1979: I. Study design, )] TJ ET BT 26.250 435.196 Td /F1 9.8 Tf [(methods, and the occurrence of infections by age and time. Am J Epidemiol 116: 212227.)] TJ ET BT 26.250 415.791 Td /F1 9.8 Tf [(9.)] TJ ET BT 38.132 415.791 Td /F1 9.8 Tf [(Monto AS, Koopman JS, Longini IM Jr \(1985\) Tecumseh study of illness: XIII. In?uenza infection and disease, 1976-1981. )] TJ ET BT 26.250 403.887 Td /F1 9.8 Tf [(Am J Epidemiol 121: 811822.)] TJ ET BT 26.250 384.482 Td /F1 9.8 Tf [(10.)] TJ ET BT 43.553 384.482 Td /F1 9.8 Tf [(Reichert TA, Sugaya N, Fedson DS, Glezen WP, Simonsen L, et al. \(2001\) The Japanese experience with vaccinating )] TJ ET BT 26.250 372.577 Td /F1 9.8 Tf [(schoolchildren against in?uenza. N Engl J Med 344: 889896.)] TJ ET BT 26.250 353.172 Td /F1 9.8 Tf [(11.)] TJ ET BT 43.553 353.172 Td /F1 9.8 Tf [(Bansal, Shweta; Pourbohloul, Babak; Hupert, Nathaniel; Grenfell, Bryan; Meyers, Lauren Ancel. The Shifting Demographic )] TJ ET BT 26.250 341.268 Td /F1 9.8 Tf [(Landscape of Influenza [Internet]. Version 41. PLoS Currents: Influenza. 2009 Sep 30 [revised 2009 Oct 5]:RRN1047. )] TJ ET BT 26.250 329.363 Td /F1 9.8 Tf [(http://knol.google.com/k/shweta-bansal/the-shifting-demographic-landscape-of/tkwn3sjme3vo/1)] TJ ET BT 26.250 309.958 Td /F1 9.8 Tf [(12.)] TJ ET BT 43.553 309.958 Td /F1 9.8 Tf [(Medlock J, Galvani AP \(2009\) Optimizing in?uenza vaccine distribution. Science 325: 17051708.)] TJ ET BT 26.250 290.553 Td /F1 9.8 Tf [(13.)] TJ ET BT 43.553 290.553 Td /F1 9.8 Tf [(Presanis, Anne M; Lipsitch, Marc; Daniela De Angelis; New York City Department of Health and Mental Hygiene, Swine Flu )] TJ ET BT 26.250 278.649 Td /F1 9.8 Tf [(Investigation Team,; Hagy, Angie; Reed, Carrie; Riley, Steven; Cooper, Ben; Biedrzycki, Paul; Finelli, Lyn; Jade. The severity of )] TJ ET BT 26.250 266.744 Td /F1 9.8 Tf [(pandemic H1N1 influenza in the United States, April July 2009 [Internet]. Version 38. PLoS Currents: Influenza. 2009 Sep 25 )] TJ ET BT 26.250 254.839 Td /F1 9.8 Tf [([revised 2009 Nov 18]:RRN1042. http://knol.google.com/k/anne-m-presanis/the-severity-of-pandemic-h1n1-)] TJ ET BT 26.250 242.934 Td /F1 9.8 Tf [(influenza/agr0htar1u6r/16)] TJ ET BT 26.250 223.530 Td /F1 9.8 Tf [(14.)] TJ ET BT 43.553 223.530 Td /F1 9.8 Tf [(Novel Swine-Origin In?uenza A \(H1N1\) Virus Investigation Team \(2009\) Emergence of a novel swine-origin in?uenza A )] TJ ET BT 26.250 211.625 Td /F1 9.8 Tf [(\(H1N1\) virus in humans. N Engl J Med 360: 2605.)] TJ ET BT 26.250 192.220 Td /F1 9.8 Tf [(15.)] TJ ET BT 43.553 192.220 Td /F1 9.8 Tf [(Shinde V, Bridges CB, Uyeki TM, Shu B, Balish A, et al. \(2009\) Triple-reassortant swine in?uenza A \(H1\) in humans in the )] TJ ET BT 26.250 180.315 Td /F1 9.8 Tf [(United States, 20052009. N Engl J Med 360: 26162125.)] TJ ET BT 26.250 160.911 Td /F1 9.8 Tf [(16.)] TJ ET BT 43.553 160.911 Td /F1 9.8 Tf [(US Centers for Disease Control and Prevention \(Accessed 20 October, 2009\) ACIP Presentation Slides: Special July 2009 )] TJ ET BT 26.250 149.006 Td /F1 9.8 Tf [(Meeting. \(A Klimov: Virology and immunology update, K Neuzil & A Fiore: ACIP in?uenza work group considerations\). http: )] TJ ET BT 26.250 137.101 Td /F1 9.8 Tf [(//www.cdc.gov/vaccines/recs/acip/slides-july09-flu.htm)] TJ ET BT 26.250 117.696 Td /F1 9.8 Tf [(17.)] TJ ET BT 43.553 117.696 Td /F1 9.8 Tf [(Mossong J, Hens N, Jit M, Beutels P, Auranen K, et al. \(2008\) Social contacts and mixing patterns relevant to the spread of )] TJ ET BT 26.250 105.792 Td /F1 9.8 Tf [(infectious diseases. PLoS Med 5: e74.)] TJ ET BT 26.250 86.387 Td /F1 9.8 Tf [(18.)] TJ ET BT 43.553 86.387 Td /F1 9.8 Tf [(Fraser C, Donnelly CA, Cauchemez S, Hanage WP, Van Kerkhove MD, et al. \(2009\) Pandemic potential of a strain of )] TJ ET BT 26.250 74.482 Td /F1 9.8 Tf [(in?uenza A \(H1N1\): Early ?ndings. Science 324: 15571561.)] TJ ET BT 26.250 55.077 Td /F1 9.8 Tf [(19.)] TJ ET BT 43.553 55.077 Td /F1 9.8 Tf [(MIDAS High-Risk Segmentation Group \(2009\). Personal communication \(Diane Wagener\).)] TJ ET Q q 15.000 45.196 577.500 731.804 re W n 0.271 0.267 0.267 rg BT 26.250 750.278 Td /F4 12.0 Tf [(Competing Interests)] TJ ET BT 26.250 730.324 Td /F1 9.8 Tf [(All of the authors have no competing financial, personal, or professional interests that have influenced this paper.)] TJ ET BT 26.250 693.722 Td /F4 12.0 Tf [(References)] TJ ET BT 26.250 666.267 Td /F1 9.8 Tf [(1.)] TJ ET BT 38.132 666.267 Td /F1 9.8 Tf [(US Centers for Disease Control and Prevention \(Accessed 20 October, 2009\) 2009 H1N1 In?uenza Vaccine Supply Status )] TJ ET BT 26.250 654.363 Td /F1 9.8 Tf [(http://www.cdc.gov/h1n1flu/vaccination/updates/101609.htm)] TJ ET BT 26.250 634.958 Td /F1 9.8 Tf [(2.)] TJ ET BT 38.132 634.958 Td /F1 9.8 Tf [(US Centers for Disease Control and Prevention \(Accessed 20 October, 2009\) CDC joint brie?ng with NIH & FDA on 2009 )] TJ ET BT 26.250 623.053 Td /F1 9.8 Tf [(H1N1 In?uenza, August 21, 2009, 12:00 p.m. http://www.cdc.gov/ media/transcripts/2009/t090821.htm)] TJ ET BT 26.250 603.648 Td /F1 9.8 Tf [(3.)] TJ ET BT 38.132 603.648 Td /F1 9.8 Tf [(Robinson R \(2009\). Personal communication.)] TJ ET BT 26.250 584.244 Td /F1 9.8 Tf [(4.)] TJ ET BT 38.132 584.244 Td /F1 9.8 Tf [(National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention \(Accessed 20 )] TJ ET BT 26.250 572.339 Td /F1 9.8 Tf [(October 2009\) Use of in?uenza A \(H1N1\) 2009 monovalent vaccine. http://www.cdc. )] TJ ET BT 26.250 560.434 Td /F1 9.8 Tf [(gov/mmwr/preview/mmwrhtml/rr58e0821a1.htm)] TJ ET BT 26.250 541.029 Td /F1 9.8 Tf [(5.)] TJ ET BT 38.132 541.029 Td /F1 9.8 Tf [(Monto A, Davenport F, Napier J, Francis T \(1969\) E?ect of vaccination of a school-age population upon the course of an A2-)] TJ ET BT 26.250 529.125 Td /F1 9.8 Tf [(Hong Kong in?uenza epidemic. Bull World Health Organ 41: 537542.)] TJ ET BT 26.250 509.720 Td /F1 9.8 Tf [(6.)] TJ ET BT 38.132 509.720 Td /F1 9.8 Tf [(Taber L, Paredes A, Glezen W, Couch R \(1981\) Infection with in?uenza A/Victoria virus in Houston families, 1976. J Hyg )] TJ ET BT 26.250 497.815 Td /F1 9.8 Tf [(\(Lond\) 86: 30313.)] TJ ET BT 26.250 478.410 Td /F1 9.8 Tf [(7.)] TJ ET BT 38.132 478.410 Td /F1 9.8 Tf [(Longini IM Jr, Koopman JS, Monto AS, Fox JP \(1982\) Estimating household and community transmission parameters for )] TJ ET BT 26.250 466.506 Td /F1 9.8 Tf [(in?uenza. Am J Epidemiol 115: 736751.)] TJ ET BT 26.250 447.101 Td /F1 9.8 Tf [(8.)] TJ ET BT 38.132 447.101 Td /F1 9.8 Tf [(Fox JP, Hall CE, Cooney MK, Foy HM \(1982\) In?uenzavirus infections in Seattle families, 1975-1979: I. Study design, )] TJ ET BT 26.250 435.196 Td /F1 9.8 Tf [(methods, and the occurrence of infections by age and time. Am J Epidemiol 116: 212227.)] TJ ET BT 26.250 415.791 Td /F1 9.8 Tf [(9.)] TJ ET BT 38.132 415.791 Td /F1 9.8 Tf [(Monto AS, Koopman JS, Longini IM Jr \(1985\) Tecumseh study of illness: XIII. In?uenza infection and disease, 1976-1981. )] TJ ET BT 26.250 403.887 Td /F1 9.8 Tf [(Am J Epidemiol 121: 811822.)] TJ ET BT 26.250 384.482 Td /F1 9.8 Tf [(10.)] TJ ET BT 43.553 384.482 Td /F1 9.8 Tf [(Reichert TA, Sugaya N, Fedson DS, Glezen WP, Simonsen L, et al. \(2001\) The Japanese experience with vaccinating )] TJ ET BT 26.250 372.577 Td /F1 9.8 Tf [(schoolchildren against in?uenza. N Engl J Med 344: 889896.)] TJ ET BT 26.250 353.172 Td /F1 9.8 Tf [(11.)] TJ ET BT 43.553 353.172 Td /F1 9.8 Tf [(Bansal, Shweta; Pourbohloul, Babak; Hupert, Nathaniel; Grenfell, Bryan; Meyers, Lauren Ancel. The Shifting Demographic )] TJ ET BT 26.250 341.268 Td /F1 9.8 Tf [(Landscape of Influenza [Internet]. Version 41. PLoS Currents: Influenza. 2009 Sep 30 [revised 2009 Oct 5]:RRN1047. )] TJ ET BT 26.250 329.363 Td /F1 9.8 Tf [(http://knol.google.com/k/shweta-bansal/the-shifting-demographic-landscape-of/tkwn3sjme3vo/1)] TJ ET BT 26.250 309.958 Td /F1 9.8 Tf [(12.)] TJ ET BT 43.553 309.958 Td /F1 9.8 Tf [(Medlock J, Galvani AP \(2009\) Optimizing in?uenza vaccine distribution. Science 325: 17051708.)] TJ ET BT 26.250 290.553 Td /F1 9.8 Tf [(13.)] TJ ET BT 43.553 290.553 Td /F1 9.8 Tf [(Presanis, Anne M; Lipsitch, Marc; Daniela De Angelis; New York City Department of Health and Mental Hygiene, Swine Flu )] TJ ET BT 26.250 278.649 Td /F1 9.8 Tf [(Investigation Team,; Hagy, Angie; Reed, Carrie; Riley, Steven; Cooper, Ben; Biedrzycki, Paul; Finelli, Lyn; Jade. The severity of )] TJ ET BT 26.250 266.744 Td /F1 9.8 Tf [(pandemic H1N1 influenza in the United States, April July 2009 [Internet]. Version 38. PLoS Currents: Influenza. 2009 Sep 25 )] TJ ET BT 26.250 254.839 Td /F1 9.8 Tf [([revised 2009 Nov 18]:RRN1042. http://knol.google.com/k/anne-m-presanis/the-severity-of-pandemic-h1n1-)] TJ ET BT 26.250 242.934 Td /F1 9.8 Tf [(influenza/agr0htar1u6r/16)] TJ ET BT 26.250 223.530 Td /F1 9.8 Tf [(14.)] TJ ET BT 43.553 223.530 Td /F1 9.8 Tf [(Novel Swine-Origin In?uenza A \(H1N1\) Virus Investigation Team \(2009\) Emergence of a novel swine-origin in?uenza A )] TJ ET BT 26.250 211.625 Td /F1 9.8 Tf [(\(H1N1\) virus in humans. N Engl J Med 360: 2605.)] TJ ET BT 26.250 192.220 Td /F1 9.8 Tf [(15.)] TJ ET BT 43.553 192.220 Td /F1 9.8 Tf [(Shinde V, Bridges CB, Uyeki TM, Shu B, Balish A, et al. \(2009\) Triple-reassortant swine in?uenza A \(H1\) in humans in the )] TJ ET BT 26.250 180.315 Td /F1 9.8 Tf [(United States, 20052009. N Engl J Med 360: 26162125.)] TJ ET BT 26.250 160.911 Td /F1 9.8 Tf [(16.)] TJ ET BT 43.553 160.911 Td /F1 9.8 Tf [(US Centers for Disease Control and Prevention \(Accessed 20 October, 2009\) ACIP Presentation Slides: Special July 2009 )] TJ ET BT 26.250 149.006 Td /F1 9.8 Tf [(Meeting. \(A Klimov: Virology and immunology update, K Neuzil & A Fiore: ACIP in?uenza work group considerations\). http: )] TJ ET BT 26.250 137.101 Td /F1 9.8 Tf [(//www.cdc.gov/vaccines/recs/acip/slides-july09-flu.htm)] TJ ET BT 26.250 117.696 Td /F1 9.8 Tf [(17.)] TJ ET BT 43.553 117.696 Td /F1 9.8 Tf [(Mossong J, Hens N, Jit M, Beutels P, Auranen K, et al. \(2008\) Social contacts and mixing patterns relevant to the spread of )] TJ ET BT 26.250 105.792 Td /F1 9.8 Tf [(infectious diseases. PLoS Med 5: e74.)] TJ ET BT 26.250 86.387 Td /F1 9.8 Tf [(18.)] TJ ET BT 43.553 86.387 Td /F1 9.8 Tf [(Fraser C, Donnelly CA, Cauchemez S, Hanage WP, Van Kerkhove MD, et al. \(2009\) Pandemic potential of a strain of )] TJ ET BT 26.250 74.482 Td /F1 9.8 Tf [(in?uenza A \(H1N1\): Early ?ndings. Science 324: 15571561.)] TJ ET BT 26.250 55.077 Td /F1 9.8 Tf [(19.)] TJ ET BT 43.553 55.077 Td /F1 9.8 Tf [(MIDAS High-Risk Segmentation Group \(2009\). Personal communication \(Diane Wagener\).)] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(7)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Influenza)] TJ ET Q endstream endobj 506 0 obj << /Type /Page /Parent 3 0 R /Contents 507 0 R >> endobj 507 0 obj << /Length 1849 >> stream 0.271 0.267 0.267 rg q 15.000 718.786 577.500 58.214 re W n 0.271 0.267 0.267 rg BT 26.250 759.976 Td /F1 9.8 Tf [(20.)] TJ ET BT 43.553 759.976 Td /F1 9.8 Tf [(Meltzer MI, Cox NJ, Fukuda K \(1999\) Modeling the economic impact of pandemic in?uenza in the United States: )] TJ ET BT 26.250 748.071 Td /F1 9.8 Tf [(implications for setting priorities for intervention: background paper. Technical report, Centers for Disease Control and )] TJ ET BT 26.250 736.167 Td /F1 9.8 Tf [(Prevention. Accessed 28 July, 2007. http://www.cdc.gov/ncidod/ EID/vol5no5/meltzerback.htm)] TJ ET Q q 15.000 718.786 577.500 58.214 re W n 0.271 0.267 0.267 rg BT 26.250 759.976 Td /F1 9.8 Tf [(20.)] TJ ET BT 43.553 759.976 Td /F1 9.8 Tf [(Meltzer MI, Cox NJ, Fukuda K \(1999\) Modeling the economic impact of pandemic in?uenza in the United States: )] TJ ET BT 26.250 748.071 Td /F1 9.8 Tf [(implications for setting priorities for intervention: background paper. Technical report, Centers for Disease Control and )] TJ ET BT 26.250 736.167 Td /F1 9.8 Tf [(Prevention. Accessed 28 July, 2007. http://www.cdc.gov/ncidod/ EID/vol5no5/meltzerback.htm)] TJ ET Q q 15.000 718.786 577.500 58.214 re W n 0.271 0.267 0.267 rg BT 26.250 759.976 Td /F1 9.8 Tf [(20.)] TJ ET BT 43.553 759.976 Td /F1 9.8 Tf [(Meltzer MI, Cox NJ, Fukuda K \(1999\) Modeling the economic impact of pandemic in?uenza in the United States: )] TJ ET BT 26.250 748.071 Td /F1 9.8 Tf [(implications for setting priorities for intervention: background paper. Technical report, Centers for Disease Control and )] TJ ET BT 26.250 736.167 Td /F1 9.8 Tf [(Prevention. Accessed 28 July, 2007. http://www.cdc.gov/ncidod/ EID/vol5no5/meltzerback.htm)] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(8)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Influenza)] TJ ET Q endstream endobj xref 0 508 0000000000 65535 f 0000000008 00000 n 0000000073 00000 n 0000000119 00000 n 0000003298 00000 n 0000003335 00000 n 0000003551 00000 n 0000003794 00000 n 0000023688 00000 n 0000023795 00000 n 0000023903 00000 n 0000024014 00000 n 0000024127 00000 n 0000024515 00000 n 0000028347 00000 n 0000028474 00000 n 0000028621 00000 n 0000028748 00000 n 0000028895 00000 n 0000029022 00000 n 0000029129 00000 n 0000029257 00000 n 0000029365 00000 n 0000029493 00000 n 0000029598 00000 n 0000029726 00000 n 0000029762 00000 n 0000029890 00000 n 0000029926 00000 n 0000030054 00000 n 0000030090 00000 n 0000030217 00000 n 0000030364 00000 n 0000030491 00000 n 0000030638 00000 n 0000030765 00000 n 0000030872 00000 n 0000031000 00000 n 0000031108 00000 n 0000031236 00000 n 0000031341 00000 n 0000031469 00000 n 0000031505 00000 n 0000031633 00000 n 0000031669 00000 n 0000031797 00000 n 0000031833 00000 n 0000031960 00000 n 0000032107 00000 n 0000032234 00000 n 0000032381 00000 n 0000032508 00000 n 0000032615 00000 n 0000032743 00000 n 0000032851 00000 n 0000032979 00000 n 0000033084 00000 n 0000033212 00000 n 0000033248 00000 n 0000033376 00000 n 0000033412 00000 n 0000033540 00000 n 0000033576 00000 n 0000033717 00000 n 0000053125 00000 n 0000053253 00000 n 0000053289 00000 n 0000053416 00000 n 0000053533 00000 n 0000053940 00000 n 0000070258 00000 n 0000070726 00000 n 0000070998 00000 n 0000071631 00000 n 0000071911 00000 n 0000072536 00000 n 0000072816 00000 n 0000072942 00000 n 0000073055 00000 n 0000073709 00000 n 0000106760 00000 n 0000106888 00000 n 0000106924 00000 n 0000107051 00000 n 0000107168 00000 n 0000107575 00000 n 0000123893 00000 n 0000124361 00000 n 0000124633 00000 n 0000125266 00000 n 0000125546 00000 n 0000126171 00000 n 0000126451 00000 n 0000126577 00000 n 0000126690 00000 n 0000127344 00000 n 0000160395 00000 n 0000160523 00000 n 0000160559 00000 n 0000160686 00000 n 0000160803 00000 n 0000161211 00000 n 0000177531 00000 n 0000178000 00000 n 0000178274 00000 n 0000178908 00000 n 0000179190 00000 n 0000179816 00000 n 0000180098 00000 n 0000180226 00000 n 0000180340 00000 n 0000180995 00000 n 0000214048 00000 n 0000214456 00000 n 0000230776 00000 n 0000231431 00000 n 0000264484 00000 n 0000264803 00000 n 0000290707 00000 n 0000291341 00000 n 0000291623 00000 n 0000291753 00000 n 0000291790 00000 n 0000291920 00000 n 0000291957 00000 n 0000292087 00000 n 0000292124 00000 n 0000292254 00000 n 0000292291 00000 n 0000292421 00000 n 0000292458 00000 n 0000292588 00000 n 0000292625 00000 n 0000292755 00000 n 0000292792 00000 n 0000292922 00000 n 0000292959 00000 n 0000293089 00000 n 0000293126 00000 n 0000293815 00000 n 0000294097 00000 n 0000294227 00000 n 0000294264 00000 n 0000294898 00000 n 0000295180 00000 n 0000295310 00000 n 0000295347 00000 n 0000295477 00000 n 0000295514 00000 n 0000295644 00000 n 0000295681 00000 n 0000295811 00000 n 0000295848 00000 n 0000295978 00000 n 0000296015 00000 n 0000296145 00000 n 0000296182 00000 n 0000296312 00000 n 0000296349 00000 n 0000296479 00000 n 0000296516 00000 n 0000296646 00000 n 0000296683 00000 n 0000297372 00000 n 0000297654 00000 n 0000297784 00000 n 0000297821 00000 n 0000298455 00000 n 0000298737 00000 n 0000298867 00000 n 0000298904 00000 n 0000299034 00000 n 0000299071 00000 n 0000299201 00000 n 0000299238 00000 n 0000299368 00000 n 0000299405 00000 n 0000299535 00000 n 0000299572 00000 n 0000299702 00000 n 0000299739 00000 n 0000299869 00000 n 0000299906 00000 n 0000300036 00000 n 0000300073 00000 n 0000300203 00000 n 0000300240 00000 n 0000300929 00000 n 0000301211 00000 n 0000301341 00000 n 0000301378 00000 n 0000301841 00000 n 0000322252 00000 n 0000322382 00000 n 0000322419 00000 n 0000322549 00000 n 0000322586 00000 n 0000322716 00000 n 0000322753 00000 n 0000322883 00000 n 0000322920 00000 n 0000323050 00000 n 0000323087 00000 n 0000323217 00000 n 0000323254 00000 n 0000323384 00000 n 0000323421 00000 n 0000323551 00000 n 0000323588 00000 n 0000324057 00000 n 0000324331 00000 n 0000324709 00000 n 0000324982 00000 n 0000325112 00000 n 0000325149 00000 n 0000325791 00000 n 0000326073 00000 n 0000326463 00000 n 0000326736 00000 n 0000327190 00000 n 0000327463 00000 n 0000327593 00000 n 0000327630 00000 n 0000327759 00000 n 0000327796 00000 n 0000327925 00000 n 0000327962 00000 n 0000328091 00000 n 0000328205 00000 n 0000328334 00000 n 0000328452 00000 n 0000328860 00000 n 0000345186 00000 n 0000345655 00000 n 0000345929 00000 n 0000346563 00000 n 0000346845 00000 n 0000347235 00000 n 0000347508 00000 n 0000347637 00000 n 0000347755 00000 n 0000348163 00000 n 0000364788 00000 n 0000365257 00000 n 0000365531 00000 n 0000366165 00000 n 0000366447 00000 n 0000366574 00000 n 0000366696 00000 n 0000367104 00000 n 0000383507 00000 n 0000383637 00000 n 0000383674 00000 n 0000383804 00000 n 0000383841 00000 n 0000383971 00000 n 0000384008 00000 n 0000384138 00000 n 0000384175 00000 n 0000384305 00000 n 0000384342 00000 n 0000384472 00000 n 0000384509 00000 n 0000384639 00000 n 0000384676 00000 n 0000384806 00000 n 0000384843 00000 n 0000385312 00000 n 0000385586 00000 n 0000385964 00000 n 0000386237 00000 n 0000386367 00000 n 0000386404 00000 n 0000387046 00000 n 0000387328 00000 n 0000387718 00000 n 0000387991 00000 n 0000388445 00000 n 0000388718 00000 n 0000388848 00000 n 0000388885 00000 n 0000389014 00000 n 0000389051 00000 n 0000389180 00000 n 0000389217 00000 n 0000389346 00000 n 0000389460 00000 n 0000389589 00000 n 0000389707 00000 n 0000390115 00000 n 0000406441 00000 n 0000406910 00000 n 0000407184 00000 n 0000407818 00000 n 0000408100 00000 n 0000408490 00000 n 0000408763 00000 n 0000408892 00000 n 0000409010 00000 n 0000409418 00000 n 0000426043 00000 n 0000426512 00000 n 0000426786 00000 n 0000427420 00000 n 0000427702 00000 n 0000427829 00000 n 0000427951 00000 n 0000428359 00000 n 0000444762 00000 n 0000444892 00000 n 0000444929 00000 n 0000445059 00000 n 0000445096 00000 n 0000445226 00000 n 0000445263 00000 n 0000445393 00000 n 0000445430 00000 n 0000445560 00000 n 0000445597 00000 n 0000445727 00000 n 0000445764 00000 n 0000445894 00000 n 0000445931 00000 n 0000446061 00000 n 0000446098 00000 n 0000446567 00000 n 0000446841 00000 n 0000447219 00000 n 0000447492 00000 n 0000447622 00000 n 0000447659 00000 n 0000448301 00000 n 0000448583 00000 n 0000448973 00000 n 0000449246 00000 n 0000449700 00000 n 0000449973 00000 n 0000450103 00000 n 0000450140 00000 n 0000450269 00000 n 0000450306 00000 n 0000450435 00000 n 0000450472 00000 n 0000450601 00000 n 0000450715 00000 n 0000450844 00000 n 0000450962 00000 n 0000451370 00000 n 0000467696 00000 n 0000468165 00000 n 0000468439 00000 n 0000469073 00000 n 0000469355 00000 n 0000469745 00000 n 0000470018 00000 n 0000470147 00000 n 0000470265 00000 n 0000470673 00000 n 0000487298 00000 n 0000487767 00000 n 0000488041 00000 n 0000488675 00000 n 0000488957 00000 n 0000489084 00000 n 0000489206 00000 n 0000489614 00000 n 0000506017 00000 n 0000506425 00000 n 0000522751 00000 n 0000523159 00000 n 0000539784 00000 n 0000540192 00000 n 0000556595 00000 n 0000556770 00000 n 0000569123 00000 n 0000569765 00000 n 0000570047 00000 n 0000570176 00000 n 0000570308 00000 n 0000570716 00000 n 0000586797 00000 n 0000586926 00000 n 0000587048 00000 n 0000587456 00000 n 0000603914 00000 n 0000604548 00000 n 0000604830 00000 n 0000604959 00000 n 0000605091 00000 n 0000605499 00000 n 0000621804 00000 n 0000621932 00000 n 0000622054 00000 n 0000622462 00000 n 0000639577 00000 n 0000640219 00000 n 0000640501 00000 n 0000640630 00000 n 0000640762 00000 n 0000641170 00000 n 0000657251 00000 n 0000657380 00000 n 0000657502 00000 n 0000657910 00000 n 0000674368 00000 n 0000675002 00000 n 0000675284 00000 n 0000675413 00000 n 0000675545 00000 n 0000675953 00000 n 0000692258 00000 n 0000692386 00000 n 0000692508 00000 n 0000692916 00000 n 0000710031 00000 n 0000710673 00000 n 0000710955 00000 n 0000711084 00000 n 0000711216 00000 n 0000711624 00000 n 0000727705 00000 n 0000727834 00000 n 0000727956 00000 n 0000728364 00000 n 0000744822 00000 n 0000745456 00000 n 0000745738 00000 n 0000745867 00000 n 0000745999 00000 n 0000746407 00000 n 0000762712 00000 n 0000762840 00000 n 0000762962 00000 n 0000763370 00000 n 0000780485 00000 n 0000780893 00000 n 0000796974 00000 n 0000797382 00000 n 0000813840 00000 n 0000814248 00000 n 0000830553 00000 n 0000830961 00000 n 0000848076 00000 n 0000848227 00000 n 0000860175 00000 n 0000860801 00000 n 0000861083 00000 n 0000861212 00000 n 0000861344 00000 n 0000861752 00000 n 0000879238 00000 n 0000879864 00000 n 0000880146 00000 n 0000880275 00000 n 0000880397 00000 n 0000880805 00000 n 0000896980 00000 n 0000897669 00000 n 0000897951 00000 n 0000898080 00000 n 0000898212 00000 n 0000898620 00000 n 0000914795 00000 n 0000915421 00000 n 0000915703 00000 n 0000915832 00000 n 0000915964 00000 n 0000916372 00000 n 0000933858 00000 n 0000934484 00000 n 0000934766 00000 n 0000934895 00000 n 0000935017 00000 n 0000935425 00000 n 0000951600 00000 n 0000952289 00000 n 0000952571 00000 n 0000952700 00000 n 0000952832 00000 n 0000953240 00000 n 0000969415 00000 n 0000970041 00000 n 0000970323 00000 n 0000970452 00000 n 0000970584 00000 n 0000970992 00000 n 0000988478 00000 n 0000989104 00000 n 0000989386 00000 n 0000989515 00000 n 0000989637 00000 n 0000990045 00000 n 0001006220 00000 n 0001006909 00000 n 0001007191 00000 n 0001007320 00000 n 0001007452 00000 n 0001007860 00000 n 0001024035 00000 n 0001024443 00000 n 0001041929 00000 n 0001042337 00000 n 0001058512 00000 n 0001058920 00000 n 0001075095 00000 n 0001075162 00000 n 0001095459 00000 n 0001095526 00000 n trailer << /Size 508 /Root 1 0 R /Info 5 0 R >> startxref 1097429 %%EOF