Author Profile

Tim Pyrkov

Affiliation: Quantum Pharmaceuticals, ul. Kosmonavta Volkova 6A-606, Moscow, Russia, 125171

Recent Posts

Structure-based drug design of a new chemical class of small molecules active against influenza A nucleoprotein in vitro and in vivo

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We report preliminary results and a summary of a bottom-up approach to identify new, active, nontoxic, small-molecule antivirals designed to have а novel mechanism of action. We employed the procedure to identify 3-mercapto-1,2,4-triazoles derivatives as potential NP inhibitors in silico and subsequently demonstrated the in vitro efficacy of the molecules against various strains of the influenza A virus. The most efficacious compounds were successfully tested in an in vivo influenza challenge experiment.