%PDF-1.3 1 0 obj << /Type /Catalog /Outlines 2 0 R /Pages 3 0 R >> endobj 2 0 obj << /Type /Outlines /Count 0 >> endobj 3 0 obj << /Type /Pages /Kids [6 0 R 110 0 R 130 0 R 158 0 R 180 0 R 238 0 R ] /Count 6 /Resources << /ProcSet 4 0 R /Font << /F1 8 0 R /F2 9 0 R /F3 10 0 R /F4 11 0 R >> /XObject << /I1 12 0 R /I2 13 0 R /I3 138 0 R /I4 139 0 R /I5 146 0 R /I6 147 0 R /I7 154 0 R /I8 155 0 R /I9 156 0 R /I10 157 0 R /I11 162 0 R /I12 163 0 R /I13 168 0 R /I14 169 0 R /I15 174 0 R /I16 175 0 R /I17 178 0 R /I18 179 0 R /I19 184 0 R /I20 185 0 R /I21 202 0 R /I22 203 0 R /I23 220 0 R /I24 221 0 R /I25 236 0 R /I26 237 0 R >> >> /MediaBox [0.000 0.000 612.000 792.000] >> endobj 4 0 obj [/PDF /Text /ImageC ] endobj 5 0 obj << /Creator (DOMPDF) /CreationDate (D:20180720090708+00'00') /ModDate (D:20180720090708+00'00') /Title (SeqMonitor: Influenza Analysis Pipeline and Visualization PLOS Currents Influenza) >> endobj 6 0 obj << /Type /Page /Parent 3 0 R /Annots [ 14 0 R 16 0 R 18 0 R 20 0 R 22 0 R 24 0 R 26 0 R 28 0 R 30 0 R 32 0 R 34 0 R 36 0 R 38 0 R 40 0 R 42 0 R 44 0 R 46 0 R 48 0 R 50 0 R 52 0 R 54 0 R 56 0 R 58 0 R 60 0 R 62 0 R 64 0 R 66 0 R 68 0 R 70 0 R 72 0 R 74 0 R 76 0 R 78 0 R 80 0 R 82 0 R 84 0 R 86 0 R 88 0 R 90 0 R 92 0 R 94 0 R 96 0 R 98 0 R 100 0 R 102 0 R 104 0 R 106 0 R 108 0 R ] /Contents 7 0 R >> endobj 7 0 obj << /Length 23684 >> stream q 375.000 0 0 39.000 222.000 738.000 cm /I2 Do Q q 15.000 709.302 577.500 28.698 re W n 0.267 0.267 0.267 rg BT 15.000 718.042 Td /F2 21.0 Tf [(SeqMonitor: Influenza Analysis Pipeline and Visualization)] TJ ET Q 0.271 0.267 0.267 rg BT 15.000 700.036 Td /F3 9.8 Tf [(September 23, 2009)] TJ ET 0.267 0.267 0.267 rg BT 26.250 688.195 Td /F1 9.8 Tf [(Norman MacDonald)] TJ ET 0.271 0.267 0.267 rg BT 112.937 688.195 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 118.358 688.195 Td /F1 9.8 Tf [(Donovan Parks)] TJ ET 0.271 0.267 0.267 rg BT 185.009 688.195 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 190.430 688.195 Td /F1 9.8 Tf [(Robert Beiko)] TJ ET 0.271 0.267 0.267 rg BT 26.250 676.290 Td /F1 9.8 Tf [(MacDonald N, Parks D, Beiko R. SeqMonitor: Influenza Analysis Pipeline and Visualization. PLOS Currents Influenza. 2009 )] TJ ET BT 26.250 664.386 Td /F1 9.8 Tf [(Sep 23 . Edition 1. doi: 10.1371/currents.RRN1040.)] TJ ET q 15.000 29.359 577.500 632.646 re W n 0.271 0.267 0.267 rg BT 26.250 635.283 Td /F4 12.0 Tf [(Abstract)] TJ ET BT 26.250 615.329 Td /F1 9.8 Tf [(Unprecedented sequencing effort has led to daily submissions of influenza genomes to public repositories such as the NCBI )] TJ ET BT 26.250 603.424 Td /F1 9.8 Tf [(GenBank. With the decreasing cost of genome sequencing, it is expected that rapidly evolving viruses such as influenza will be )] TJ ET BT 26.250 591.519 Td /F1 9.8 Tf [(sampled in even greater depth in the future. Keeping analyses up to date and managing this data is a prime concern for )] TJ ET BT 26.250 579.615 Td /F1 9.8 Tf [(researchers and public-health officials alike. We have developed an influenza sequence pipeline, polymorphism data )] TJ ET BT 26.250 567.710 Td /F1 9.8 Tf [(warehouse, and an interactive web-based analysis program to assist in managing the flow of sequence data. The system )] TJ ET BT 26.250 555.805 Td /F1 9.8 Tf [(provides a framework for studying polymorphic associations with various metadata, for downloading subsets based on metadata )] TJ ET BT 26.250 543.900 Td /F1 9.8 Tf [(criteria, as well as for tracking polymorphisms geographically and temporally. SeqMonitor is accessible at )] TJ ET BT 26.250 531.996 Td /F1 9.8 Tf [(http://ratite.cs.dal.ca/SeqMonitor.)] TJ ET BT 26.250 495.393 Td /F4 12.0 Tf [(Introduction)] TJ ET BT 26.250 475.439 Td /F1 9.8 Tf [(In early 2009, a triple-reassortant strain of the H1N1 serotype, here-in called S-OIV \(also known as H1N1pdm\), spread )] TJ ET BT 26.250 463.534 Td /F1 9.8 Tf [(throughout the world, causing a pandemic. The first significant human outbreak of this strain occurred in La Gloria, Veracruz, )] TJ ET BT 26.250 451.629 Td /F1 9.8 Tf [(Mexico in February 2009 )] TJ ET 0.267 0.267 0.267 rg BT 136.250 451.629 Td /F1 9.8 Tf [([1])] TJ ET BT 147.091 451.629 Td /F1 9.8 Tf [([2])] TJ ET 0.271 0.267 0.267 rg BT 157.934 451.629 Td /F1 9.8 Tf [( . As of 6 Sep 2009, 3205 S-OIV-related deaths worldwide have been reported to the WHO )] TJ ET 0.267 0.267 0.267 rg BT 551.931 451.629 Td /F1 9.8 Tf [([3])] TJ ET 0.271 0.267 0.267 rg BT 562.773 451.629 Td /F1 9.8 Tf [( . )] TJ ET BT 26.250 439.725 Td /F1 9.8 Tf [(Although treatment concerns have been prompted by resistance to the antiviral oseltamivir in the latest S-OIV strains, the virus )] TJ ET BT 26.250 427.820 Td /F1 9.8 Tf [(largely remains sensitive to zanamivir )] TJ ET 0.267 0.267 0.267 rg BT 190.957 427.820 Td /F1 9.8 Tf [([4])] TJ ET 0.271 0.267 0.267 rg BT 201.799 427.820 Td /F1 9.8 Tf [( . Resistance to oseltamivir is often conferred by a single His274Tyr amino acid )] TJ ET BT 26.250 415.915 Td /F1 9.8 Tf [(mutation in the neuraminidase gene, while reduced zanamivir sensitivity has recently been experimentally linked to a Gln136Lys )] TJ ET BT 26.250 404.010 Td /F1 9.8 Tf [(mutation \(N2 numbering\).)] TJ ET BT 26.250 384.606 Td /F1 9.8 Tf [(Systems recently developed and under development are allowing the quick identification of important, novel mutations using 3-d )] TJ ET BT 26.250 372.701 Td /F1 9.8 Tf [(protein structures )] TJ ET 0.267 0.267 0.267 rg BT 104.279 372.701 Td /F1 9.8 Tf [([5])] TJ ET 0.271 0.267 0.267 rg BT 115.121 372.701 Td /F1 9.8 Tf [( , as well as H3N2 antigenic-site-based vaccine prediction systems \( )] TJ ET 0.267 0.267 0.267 rg BT 26.250 360.796 Td /F1 9.8 Tf [(http://influenza.nhri.org.tw/ATIVS/index.jsp)] TJ ET 0.271 0.267 0.267 rg BT 209.959 360.796 Td /F1 9.8 Tf [( \) )] TJ ET 0.267 0.267 0.267 rg BT 218.627 360.796 Td /F1 9.8 Tf [([6])] TJ ET 0.271 0.267 0.267 rg BT 229.469 360.796 Td /F1 9.8 Tf [( . This type of automated detection and monitoring of novel mutations affecting )] TJ ET BT 26.250 348.891 Td /F1 9.8 Tf [(antigenicity, convergent evolution, and inter/intra-host reassortment needs to be performed on a continual basis on the ever-)] TJ ET BT 26.250 336.987 Td /F1 9.8 Tf [(increasing dataset to keep abreast of new influenza threats. To this end, we have created an automated pipeline that can )] TJ ET BT 26.250 325.082 Td /F1 9.8 Tf [(download the latest sequences from NCBI GenBank and add them to existing alignments of homologous sequences, as well as )] TJ ET BT 26.250 313.177 Td /F1 9.8 Tf [(extract metadata such as antiviral resistance, collection date and location name. Each sequence can then be geotagged by an )] TJ ET BT 26.250 301.272 Td /F1 9.8 Tf [(automated, user-verified extraction and querying engine which uses the GeoNames web service \( )] TJ ET 0.267 0.267 0.267 rg BT 449.468 301.272 Td /F1 9.8 Tf [(http://www.geonames.org)] TJ ET 0.271 0.267 0.267 rg BT 560.014 301.272 Td /F1 9.8 Tf [( \). )] TJ ET BT 26.250 289.368 Td /F1 9.8 Tf [(The data are made available through our data warehouse and web application, SeqMonitor. The current version of SeqMonitor )] TJ ET BT 26.250 277.463 Td /F1 9.8 Tf [(allows users to submit H1N1 protein sequences of the hemagglutinin or neuraminidase genes to a BLAST query, with the top )] TJ ET BT 26.250 265.558 Td /F1 9.8 Tf [(matches being plotted on a geographic map. Novel and rare mutations of the query sequence can then be analyzed versus any )] TJ ET BT 26.250 253.653 Td /F1 9.8 Tf [(subset of the data, defined for instance by oseltamivir resistance or country of collection. The geographic and related metadata )] TJ ET BT 26.250 241.749 Td /F1 9.8 Tf [(files, along with the precomputed amino acid alignments constructed with the pipeline can be downloaded by users and )] TJ ET BT 26.250 229.844 Td /F1 9.8 Tf [(processed by geographic and sequence data analysis packages such as GenGIS \( )] TJ ET 0.267 0.267 0.267 rg BT 386.103 229.844 Td /F1 9.8 Tf [(http://kiwi.cs.dal.ca/GenGIS)] TJ ET 0.271 0.267 0.267 rg BT 505.862 229.844 Td /F1 9.8 Tf [( \) )] TJ ET 0.267 0.267 0.267 rg BT 514.530 229.844 Td /F1 9.8 Tf [([7])] TJ ET BT 525.372 229.844 Td /F1 9.8 Tf [([8])] TJ ET 0.271 0.267 0.267 rg BT 536.214 229.844 Td /F1 9.8 Tf [( . )] TJ ET BT 26.250 217.939 Td /F1 9.8 Tf [(SeqMonitor can be accessed at )] TJ ET 0.267 0.267 0.267 rg BT 165.529 217.939 Td /F1 9.8 Tf [(http://ratite.cs.dal.ca/SeqMonitor)] TJ ET 0.271 0.267 0.267 rg BT 305.344 217.939 Td /F1 9.8 Tf [( .)] TJ ET BT 26.250 181.337 Td /F4 12.0 Tf [(Methods)] TJ ET BT 26.250 161.382 Td /F4 9.8 Tf [(Data sources)] TJ ET BT 26.250 141.978 Td /F1 9.8 Tf [(All available data on the hemagglutinin and neuraminidase proteins of H1N1 human-host influenza from the NCBI Influenza )] TJ ET BT 26.250 130.073 Td /F1 9.8 Tf [(Virus Resource are downloaded and provided as input to the pipeline. The GeoNames.org webservice was used to geotag )] TJ ET BT 26.250 118.168 Td /F1 9.8 Tf [(records. Currently \(12 September 2009\), 3968 H1N1 hemagglutinin and 2889 neuraminidase records are available for analysis )] TJ ET BT 26.250 106.263 Td /F1 9.8 Tf [(with Version 1.0 of SeqMonitor.)] TJ ET Q q 15.000 709.302 577.500 28.698 re W n 0.267 0.267 0.267 rg BT 15.000 718.042 Td /F2 21.0 Tf [(SeqMonitor: Influenza Analysis Pipeline and Visualization)] TJ ET Q 0.271 0.267 0.267 rg BT 15.000 700.036 Td /F3 9.8 Tf [(September 23, 2009)] TJ ET 0.267 0.267 0.267 rg BT 26.250 688.195 Td /F1 9.8 Tf [(Norman MacDonald)] TJ ET 0.271 0.267 0.267 rg BT 112.937 688.195 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 118.358 688.195 Td /F1 9.8 Tf [(Donovan Parks)] TJ ET 0.271 0.267 0.267 rg BT 185.009 688.195 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 190.430 688.195 Td /F1 9.8 Tf [(Robert Beiko)] TJ ET 0.271 0.267 0.267 rg BT 26.250 676.290 Td /F1 9.8 Tf [(MacDonald N, Parks D, Beiko R. SeqMonitor: Influenza Analysis Pipeline and Visualization. PLOS Currents Influenza. 2009 )] TJ ET BT 26.250 664.386 Td /F1 9.8 Tf [(Sep 23 . Edition 1. doi: 10.1371/currents.RRN1040.)] TJ ET q 15.000 29.359 577.500 632.646 re W n 0.271 0.267 0.267 rg BT 26.250 635.283 Td /F4 12.0 Tf [(Abstract)] TJ ET BT 26.250 615.329 Td /F1 9.8 Tf [(Unprecedented sequencing effort has led to daily submissions of influenza genomes to public repositories such as the NCBI )] TJ ET BT 26.250 603.424 Td /F1 9.8 Tf [(GenBank. With the decreasing cost of genome sequencing, it is expected that rapidly evolving viruses such as influenza will be )] TJ ET BT 26.250 591.519 Td /F1 9.8 Tf [(sampled in even greater depth in the future. Keeping analyses up to date and managing this data is a prime concern for )] TJ ET BT 26.250 579.615 Td /F1 9.8 Tf [(researchers and public-health officials alike. We have developed an influenza sequence pipeline, polymorphism data )] TJ ET BT 26.250 567.710 Td /F1 9.8 Tf [(warehouse, and an interactive web-based analysis program to assist in managing the flow of sequence data. The system )] TJ ET BT 26.250 555.805 Td /F1 9.8 Tf [(provides a framework for studying polymorphic associations with various metadata, for downloading subsets based on metadata )] TJ ET BT 26.250 543.900 Td /F1 9.8 Tf [(criteria, as well as for tracking polymorphisms geographically and temporally. SeqMonitor is accessible at )] TJ ET BT 26.250 531.996 Td /F1 9.8 Tf [(http://ratite.cs.dal.ca/SeqMonitor.)] TJ ET BT 26.250 495.393 Td /F4 12.0 Tf [(Introduction)] TJ ET BT 26.250 475.439 Td /F1 9.8 Tf [(In early 2009, a triple-reassortant strain of the H1N1 serotype, here-in called S-OIV \(also known as H1N1pdm\), spread )] TJ ET BT 26.250 463.534 Td /F1 9.8 Tf [(throughout the world, causing a pandemic. The first significant human outbreak of this strain occurred in La Gloria, Veracruz, )] TJ ET BT 26.250 451.629 Td /F1 9.8 Tf [(Mexico in February 2009 )] TJ ET 0.267 0.267 0.267 rg BT 136.250 451.629 Td /F1 9.8 Tf [([1])] TJ ET BT 147.091 451.629 Td /F1 9.8 Tf [([2])] TJ ET 0.271 0.267 0.267 rg BT 157.934 451.629 Td /F1 9.8 Tf [( . As of 6 Sep 2009, 3205 S-OIV-related deaths worldwide have been reported to the WHO )] TJ ET 0.267 0.267 0.267 rg BT 551.931 451.629 Td /F1 9.8 Tf [([3])] TJ ET 0.271 0.267 0.267 rg BT 562.773 451.629 Td /F1 9.8 Tf [( . )] TJ ET BT 26.250 439.725 Td /F1 9.8 Tf [(Although treatment concerns have been prompted by resistance to the antiviral oseltamivir in the latest S-OIV strains, the virus )] TJ ET BT 26.250 427.820 Td /F1 9.8 Tf [(largely remains sensitive to zanamivir )] TJ ET 0.267 0.267 0.267 rg BT 190.957 427.820 Td /F1 9.8 Tf [([4])] TJ ET 0.271 0.267 0.267 rg BT 201.799 427.820 Td /F1 9.8 Tf [( . Resistance to oseltamivir is often conferred by a single His274Tyr amino acid )] TJ ET BT 26.250 415.915 Td /F1 9.8 Tf [(mutation in the neuraminidase gene, while reduced zanamivir sensitivity has recently been experimentally linked to a Gln136Lys )] TJ ET BT 26.250 404.010 Td /F1 9.8 Tf [(mutation \(N2 numbering\).)] TJ ET BT 26.250 384.606 Td /F1 9.8 Tf [(Systems recently developed and under development are allowing the quick identification of important, novel mutations using 3-d )] TJ ET BT 26.250 372.701 Td /F1 9.8 Tf [(protein structures )] TJ ET 0.267 0.267 0.267 rg BT 104.279 372.701 Td /F1 9.8 Tf [([5])] TJ ET 0.271 0.267 0.267 rg BT 115.121 372.701 Td /F1 9.8 Tf [( , as well as H3N2 antigenic-site-based vaccine prediction systems \( )] TJ ET 0.267 0.267 0.267 rg BT 26.250 360.796 Td /F1 9.8 Tf [(http://influenza.nhri.org.tw/ATIVS/index.jsp)] TJ ET 0.271 0.267 0.267 rg BT 209.959 360.796 Td /F1 9.8 Tf [( \) )] TJ ET 0.267 0.267 0.267 rg BT 218.627 360.796 Td /F1 9.8 Tf [([6])] TJ ET 0.271 0.267 0.267 rg BT 229.469 360.796 Td /F1 9.8 Tf [( . This type of automated detection and monitoring of novel mutations affecting )] TJ ET BT 26.250 348.891 Td /F1 9.8 Tf [(antigenicity, convergent evolution, and inter/intra-host reassortment needs to be performed on a continual basis on the ever-)] TJ ET BT 26.250 336.987 Td /F1 9.8 Tf [(increasing dataset to keep abreast of new influenza threats. To this end, we have created an automated pipeline that can )] TJ ET BT 26.250 325.082 Td /F1 9.8 Tf [(download the latest sequences from NCBI GenBank and add them to existing alignments of homologous sequences, as well as )] TJ ET BT 26.250 313.177 Td /F1 9.8 Tf [(extract metadata such as antiviral resistance, collection date and location name. Each sequence can then be geotagged by an )] TJ ET BT 26.250 301.272 Td /F1 9.8 Tf [(automated, user-verified extraction and querying engine which uses the GeoNames web service \( )] TJ ET 0.267 0.267 0.267 rg BT 449.468 301.272 Td /F1 9.8 Tf [(http://www.geonames.org)] TJ ET 0.271 0.267 0.267 rg BT 560.014 301.272 Td /F1 9.8 Tf [( \). )] TJ ET BT 26.250 289.368 Td /F1 9.8 Tf [(The data are made available through our data warehouse and web application, SeqMonitor. The current version of SeqMonitor )] TJ ET BT 26.250 277.463 Td /F1 9.8 Tf [(allows users to submit H1N1 protein sequences of the hemagglutinin or neuraminidase genes to a BLAST query, with the top )] TJ ET BT 26.250 265.558 Td /F1 9.8 Tf [(matches being plotted on a geographic map. Novel and rare mutations of the query sequence can then be analyzed versus any )] TJ ET BT 26.250 253.653 Td /F1 9.8 Tf [(subset of the data, defined for instance by oseltamivir resistance or country of collection. The geographic and related metadata )] TJ ET BT 26.250 241.749 Td /F1 9.8 Tf [(files, along with the precomputed amino acid alignments constructed with the pipeline can be downloaded by users and )] TJ ET BT 26.250 229.844 Td /F1 9.8 Tf [(processed by geographic and sequence data analysis packages such as GenGIS \( )] TJ ET 0.267 0.267 0.267 rg BT 386.103 229.844 Td /F1 9.8 Tf [(http://kiwi.cs.dal.ca/GenGIS)] TJ ET 0.271 0.267 0.267 rg BT 505.862 229.844 Td /F1 9.8 Tf [( \) )] TJ ET 0.267 0.267 0.267 rg BT 514.530 229.844 Td /F1 9.8 Tf [([7])] TJ ET BT 525.372 229.844 Td /F1 9.8 Tf [([8])] TJ ET 0.271 0.267 0.267 rg BT 536.214 229.844 Td /F1 9.8 Tf [( . )] TJ ET BT 26.250 217.939 Td /F1 9.8 Tf [(SeqMonitor can be accessed at )] TJ ET 0.267 0.267 0.267 rg BT 165.529 217.939 Td /F1 9.8 Tf [(http://ratite.cs.dal.ca/SeqMonitor)] TJ ET 0.271 0.267 0.267 rg BT 305.344 217.939 Td /F1 9.8 Tf [( .)] TJ ET BT 26.250 181.337 Td /F4 12.0 Tf [(Methods)] TJ ET BT 26.250 161.382 Td /F4 9.8 Tf [(Data sources)] TJ ET BT 26.250 141.978 Td /F1 9.8 Tf [(All available data on the hemagglutinin and neuraminidase proteins of H1N1 human-host influenza from the NCBI Influenza )] TJ ET BT 26.250 130.073 Td /F1 9.8 Tf [(Virus Resource are downloaded and provided as input to the pipeline. The GeoNames.org webservice was used to geotag )] TJ ET BT 26.250 118.168 Td /F1 9.8 Tf [(records. Currently \(12 September 2009\), 3968 H1N1 hemagglutinin and 2889 neuraminidase records are available for analysis )] TJ ET BT 26.250 106.263 Td /F1 9.8 Tf [(with Version 1.0 of SeqMonitor.)] TJ ET Q q 15.000 709.302 577.500 28.698 re W n 0.267 0.267 0.267 rg BT 15.000 718.042 Td /F2 21.0 Tf [(SeqMonitor: Influenza Analysis Pipeline and Visualization)] TJ ET Q 0.271 0.267 0.267 rg BT 15.000 700.036 Td /F3 9.8 Tf [(September 23, 2009)] TJ ET 0.267 0.267 0.267 rg BT 26.250 688.195 Td /F1 9.8 Tf [(Norman MacDonald)] TJ ET 0.271 0.267 0.267 rg BT 112.937 688.195 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 118.358 688.195 Td /F1 9.8 Tf [(Donovan Parks)] TJ ET 0.271 0.267 0.267 rg BT 185.009 688.195 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 190.430 688.195 Td /F1 9.8 Tf [(Robert Beiko)] TJ ET 0.271 0.267 0.267 rg BT 26.250 676.290 Td /F1 9.8 Tf [(MacDonald N, Parks D, Beiko R. SeqMonitor: Influenza Analysis Pipeline and Visualization. PLOS Currents Influenza. 2009 )] TJ ET BT 26.250 664.386 Td /F1 9.8 Tf [(Sep 23 . Edition 1. doi: 10.1371/currents.RRN1040.)] TJ ET q 15.000 29.359 577.500 632.646 re W n 0.271 0.267 0.267 rg BT 26.250 635.283 Td /F4 12.0 Tf [(Abstract)] TJ ET BT 26.250 615.329 Td /F1 9.8 Tf [(Unprecedented sequencing effort has led to daily submissions of influenza genomes to public repositories such as the NCBI )] TJ ET BT 26.250 603.424 Td /F1 9.8 Tf [(GenBank. With the decreasing cost of genome sequencing, it is expected that rapidly evolving viruses such as influenza will be )] TJ ET BT 26.250 591.519 Td /F1 9.8 Tf [(sampled in even greater depth in the future. Keeping analyses up to date and managing this data is a prime concern for )] TJ ET BT 26.250 579.615 Td /F1 9.8 Tf [(researchers and public-health officials alike. We have developed an influenza sequence pipeline, polymorphism data )] TJ ET BT 26.250 567.710 Td /F1 9.8 Tf [(warehouse, and an interactive web-based analysis program to assist in managing the flow of sequence data. The system )] TJ ET BT 26.250 555.805 Td /F1 9.8 Tf [(provides a framework for studying polymorphic associations with various metadata, for downloading subsets based on metadata )] TJ ET BT 26.250 543.900 Td /F1 9.8 Tf [(criteria, as well as for tracking polymorphisms geographically and temporally. SeqMonitor is accessible at )] TJ ET BT 26.250 531.996 Td /F1 9.8 Tf [(http://ratite.cs.dal.ca/SeqMonitor.)] TJ ET BT 26.250 495.393 Td /F4 12.0 Tf [(Introduction)] TJ ET BT 26.250 475.439 Td /F1 9.8 Tf [(In early 2009, a triple-reassortant strain of the H1N1 serotype, here-in called S-OIV \(also known as H1N1pdm\), spread )] TJ ET BT 26.250 463.534 Td /F1 9.8 Tf [(throughout the world, causing a pandemic. The first significant human outbreak of this strain occurred in La Gloria, Veracruz, )] TJ ET BT 26.250 451.629 Td /F1 9.8 Tf [(Mexico in February 2009 )] TJ ET 0.267 0.267 0.267 rg BT 136.250 451.629 Td /F1 9.8 Tf [([1])] TJ ET BT 147.091 451.629 Td /F1 9.8 Tf [([2])] TJ ET 0.271 0.267 0.267 rg BT 157.934 451.629 Td /F1 9.8 Tf [( . As of 6 Sep 2009, 3205 S-OIV-related deaths worldwide have been reported to the WHO )] TJ ET 0.267 0.267 0.267 rg BT 551.931 451.629 Td /F1 9.8 Tf [([3])] TJ ET 0.271 0.267 0.267 rg BT 562.773 451.629 Td /F1 9.8 Tf [( . )] TJ ET BT 26.250 439.725 Td /F1 9.8 Tf [(Although treatment concerns have been prompted by resistance to the antiviral oseltamivir in the latest S-OIV strains, the virus )] TJ ET BT 26.250 427.820 Td /F1 9.8 Tf [(largely remains sensitive to zanamivir )] TJ ET 0.267 0.267 0.267 rg BT 190.957 427.820 Td /F1 9.8 Tf [([4])] TJ ET 0.271 0.267 0.267 rg BT 201.799 427.820 Td /F1 9.8 Tf [( . Resistance to oseltamivir is often conferred by a single His274Tyr amino acid )] TJ ET BT 26.250 415.915 Td /F1 9.8 Tf [(mutation in the neuraminidase gene, while reduced zanamivir sensitivity has recently been experimentally linked to a Gln136Lys )] TJ ET BT 26.250 404.010 Td /F1 9.8 Tf [(mutation \(N2 numbering\).)] TJ ET BT 26.250 384.606 Td /F1 9.8 Tf [(Systems recently developed and under development are allowing the quick identification of important, novel mutations using 3-d )] TJ ET BT 26.250 372.701 Td /F1 9.8 Tf [(protein structures )] TJ ET 0.267 0.267 0.267 rg BT 104.279 372.701 Td /F1 9.8 Tf [([5])] TJ ET 0.271 0.267 0.267 rg BT 115.121 372.701 Td /F1 9.8 Tf [( , as well as H3N2 antigenic-site-based vaccine prediction systems \( )] TJ ET 0.267 0.267 0.267 rg BT 26.250 360.796 Td /F1 9.8 Tf [(http://influenza.nhri.org.tw/ATIVS/index.jsp)] TJ ET 0.271 0.267 0.267 rg BT 209.959 360.796 Td /F1 9.8 Tf [( \) )] TJ ET 0.267 0.267 0.267 rg BT 218.627 360.796 Td /F1 9.8 Tf [([6])] TJ ET 0.271 0.267 0.267 rg BT 229.469 360.796 Td /F1 9.8 Tf [( . This type of automated detection and monitoring of novel mutations affecting )] TJ ET BT 26.250 348.891 Td /F1 9.8 Tf [(antigenicity, convergent evolution, and inter/intra-host reassortment needs to be performed on a continual basis on the ever-)] TJ ET BT 26.250 336.987 Td /F1 9.8 Tf [(increasing dataset to keep abreast of new influenza threats. To this end, we have created an automated pipeline that can )] TJ ET BT 26.250 325.082 Td /F1 9.8 Tf [(download the latest sequences from NCBI GenBank and add them to existing alignments of homologous sequences, as well as )] TJ ET BT 26.250 313.177 Td /F1 9.8 Tf [(extract metadata such as antiviral resistance, collection date and location name. Each sequence can then be geotagged by an )] TJ ET BT 26.250 301.272 Td /F1 9.8 Tf [(automated, user-verified extraction and querying engine which uses the GeoNames web service \( )] TJ ET 0.267 0.267 0.267 rg BT 449.468 301.272 Td /F1 9.8 Tf [(http://www.geonames.org)] TJ ET 0.271 0.267 0.267 rg BT 560.014 301.272 Td /F1 9.8 Tf [( \). )] TJ ET BT 26.250 289.368 Td /F1 9.8 Tf [(The data are made available through our data warehouse and web application, SeqMonitor. The current version of SeqMonitor )] TJ ET BT 26.250 277.463 Td /F1 9.8 Tf [(allows users to submit H1N1 protein sequences of the hemagglutinin or neuraminidase genes to a BLAST query, with the top )] TJ ET BT 26.250 265.558 Td /F1 9.8 Tf [(matches being plotted on a geographic map. Novel and rare mutations of the query sequence can then be analyzed versus any )] TJ ET BT 26.250 253.653 Td /F1 9.8 Tf [(subset of the data, defined for instance by oseltamivir resistance or country of collection. The geographic and related metadata )] TJ ET BT 26.250 241.749 Td /F1 9.8 Tf [(files, along with the precomputed amino acid alignments constructed with the pipeline can be downloaded by users and )] TJ ET BT 26.250 229.844 Td /F1 9.8 Tf [(processed by geographic and sequence data analysis packages such as GenGIS \( )] TJ ET 0.267 0.267 0.267 rg BT 386.103 229.844 Td /F1 9.8 Tf [(http://kiwi.cs.dal.ca/GenGIS)] TJ ET 0.271 0.267 0.267 rg BT 505.862 229.844 Td /F1 9.8 Tf [( \) )] TJ ET 0.267 0.267 0.267 rg BT 514.530 229.844 Td /F1 9.8 Tf [([7])] TJ ET BT 525.372 229.844 Td /F1 9.8 Tf [([8])] TJ ET 0.271 0.267 0.267 rg BT 536.214 229.844 Td /F1 9.8 Tf [( . )] TJ ET BT 26.250 217.939 Td /F1 9.8 Tf [(SeqMonitor can be accessed at )] TJ ET 0.267 0.267 0.267 rg BT 165.529 217.939 Td /F1 9.8 Tf [(http://ratite.cs.dal.ca/SeqMonitor)] TJ ET 0.271 0.267 0.267 rg BT 305.344 217.939 Td /F1 9.8 Tf [( .)] TJ ET BT 26.250 181.337 Td /F4 12.0 Tf [(Methods)] TJ ET BT 26.250 161.382 Td /F4 9.8 Tf [(Data sources)] TJ ET BT 26.250 141.978 Td /F1 9.8 Tf [(All available data on the hemagglutinin and neuraminidase proteins of H1N1 human-host influenza from the NCBI Influenza )] TJ ET BT 26.250 130.073 Td /F1 9.8 Tf [(Virus Resource are downloaded and provided as input to the pipeline. The GeoNames.org webservice was used to geotag )] TJ ET BT 26.250 118.168 Td /F1 9.8 Tf [(records. Currently \(12 September 2009\), 3968 H1N1 hemagglutinin and 2889 neuraminidase records are available for analysis )] TJ ET BT 26.250 106.263 Td /F1 9.8 Tf [(with Version 1.0 of SeqMonitor.)] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(1)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Influenza)] TJ ET Q endstream endobj 8 0 obj << /Type /Font /Subtype /Type1 /Name /F1 /BaseFont /Helvetica /Encoding /WinAnsiEncoding >> endobj 9 0 obj << /Type /Font /Subtype /Type1 /Name /F2 /BaseFont /Times-Bold /Encoding /WinAnsiEncoding >> endobj 10 0 obj << /Type /Font /Subtype /Type1 /Name /F3 /BaseFont /Times-Italic /Encoding /WinAnsiEncoding >> endobj 11 0 obj << /Type /Font /Subtype /Type1 /Name /F4 /BaseFont /Helvetica-Bold /Encoding /WinAnsiEncoding >> endobj 12 0 obj << /Type /XObject /Subtype /Image /Width 500 /Height 52 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 500 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 144>> stream x1 0 'ݲ؎"e{dzAdzAdzAdzAdzAdzAdzAdzAdzAdzAdzAdzAtlM0\ endstream endobj 13 0 obj << /Type /XObject /Subtype /Image /Width 500 /Height 52 /SMask 12 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 500 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 3574>> stream x}ƕK*8+0T ֮ S L*0߇d" sl2FBiFwY0 00 0ŝa0 aqgR܋x||lu2 03UL۶BxI 0:UU0x;֝($z%șHڶ ÐVz ]IS> â(.* TQUuL5 $>BvpH0U:xkkGJT{OɗRNyGOΙyn)q7`(~_Ji2vgk]qVꔷ3N'ȴy4Ikm6!q:FJ)-0n܋v!^}_Z l61va_~Bxw8mv;EJY8}zzQ3]Pȹ,2_jfY4MQ[ '.uO O͋kշ9b6.#ߦUUzhf09+nKɿ4 f7Bu7ĨMfrF0`s8429j1}ZWDW;A4ҫ'TQ{7Cb[$ -"ΨMQgzN/2R7Tco*W:N݋6TUu8`RSi O>r;z^m(0w`:m=]գCE&t |ZYQ%{X[nR+zbEFΧ5pzq`ުం Ih{9G 4wMx' nmvEZ sg7?ZQ}&ҎKGuPu.j8UgNKꓙQC)s#$1䧈x[Z(|Xzc;t<~50Hh_T3Ur>a$]B8Fz[?K>Y/rQ=E4?EaLqzpX!(nNut]}e(/S\fz,<ZOEa]0 sCS_}I Y}n۶r(fg7#)h6ա}$ üvq]Aא$c0ddBDQ)ueypU-z~9Hk<$I©y'Tk`yY d}e{䨙ǐu>&w񚓶('GI\rm[G4 Sk7$B pEkYYC/ 9&Ʋ[V9MQ':X|C֨ʉ jt"ޡ+rttBռGdiM FuTEi(łv]fk"8Ldp' ^הMup2`M?dE!|KJ-\.MzکC=&¾HfR7$ev,La0+$OFuEQ"i,ːN?~E*t4qΚF:t`,{RkR]ޜ(Ԕѣ$IbN}5لS1(Ȱ$I$(eWp8Lٱ3߯ky۶&. Ck+'kL'`YG<=jͦ:l/@ߧ x$'UewYV_|H獃ׯ_ϲ,j##k4=n̲,KSq^m[P'̚ݮ(8.ﱟ5f3Mh'Ͳ I.u7~~Ӫ 3'i91ӜP j0kY4jBv04Y-CV'9H藗̑ʬEFXR8~CBBg,J}<?#&(X} vm-- 1F<6 d 䣨*mރ,;]u X.a_sOH5auUyӪ 3qwIX"@ צYZ iLA+-^!;5 ނ_gB<t 0|wX~2bўk۶{0W\.g{,O3 ֊Ѣz4pumqu&38E=X}R~mrt,۩Z]B}TSY i zʲDs# w]m+­{bqFQdu2wa+ ѣ=t,70 3[d` D"-eLwQG[0 ]h9I 0/{tFwca~!-0 B.aa~ Xa> , 0wa;0ŝa?9 endstream endobj 14 0 obj << /Type /Annot /Subtype /Link /A 15 0 R /Border [0 0 0] /H /I /Rect [ 15.0000 716.1516 540.6510 736.9416 ] >> endobj 15 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/article/seqmonitor-influenza-analysis-pipeline-and-visualization/) >> endobj 16 0 obj << /Type /Annot /Subtype /Link /A 17 0 R /Border [0 0 0] /H /I /Rect [ 26.2500 687.2933 112.9373 697.2140 ] >> endobj 17 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/author/normanmacdonald/) >> endobj 18 0 obj << /Type /Annot /Subtype /Link /A 19 0 R /Border [0 0 0] /H /I /Rect [ 118.3583 687.2933 185.0093 697.2140 ] >> endobj 19 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/author/donovanparks/) >> endobj 20 0 obj << /Type /Annot /Subtype /Link /A 21 0 R /Border [0 0 0] /H /I /Rect [ 190.4303 687.2933 246.7852 697.2140 ] >> endobj 21 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/author/robertbeiko/) >> endobj 22 0 obj << /Type /Annot /Subtype /Link /A 23 0 R /Border [0 0 0] /H /I /Rect [ 136.2495 450.7276 147.0915 460.6482 ] >> endobj 23 0 obj << /Type /Action >> endobj 24 0 obj << /Type /Annot /Subtype /Link /A 25 0 R /Border [0 0 0] /H /I /Rect [ 147.0915 450.7276 157.9335 460.6482 ] >> endobj 25 0 obj << /Type /Action >> endobj 26 0 obj << /Type /Annot /Subtype /Link /A 27 0 R /Border [0 0 0] /H /I /Rect [ 551.9310 450.7276 562.7730 460.6482 ] >> endobj 27 0 obj << /Type /Action >> endobj 28 0 obj << /Type /Annot /Subtype /Link /A 29 0 R /Border [0 0 0] /H /I /Rect [ 190.9567 426.9181 201.7988 436.8387 ] >> endobj 29 0 obj << /Type /Action >> endobj 30 0 obj << /Type /Annot /Subtype /Link /A 31 0 R /Border [0 0 0] /H /I /Rect [ 104.2793 371.7991 115.1213 381.7197 ] >> endobj 31 0 obj << /Type /Action >> endobj 32 0 obj << /Type /Annot /Subtype /Link /A 33 0 R /Border [0 0 0] /H /I /Rect [ 26.2500 359.8943 209.9595 369.8150 ] >> endobj 33 0 obj << /Type /Action /S /URI /URI (http://influenza.nhri.org.tw/ATIVS/index.jsp) >> endobj 34 0 obj << /Type /Annot /Subtype /Link /A 35 0 R /Border [0 0 0] /H /I /Rect [ 218.6273 359.8943 229.4693 369.8150 ] >> endobj 35 0 obj << /Type /Action >> endobj 36 0 obj << /Type /Annot /Subtype /Link /A 37 0 R /Border [0 0 0] /H /I /Rect [ 449.4683 300.3706 560.0138 310.2912 ] >> endobj 37 0 obj << /Type /Action /S /URI /URI (http://www.geonames.org/) >> endobj 38 0 obj << /Type /Annot /Subtype /Link /A 39 0 R /Border [0 0 0] /H /I /Rect [ 386.1030 228.9421 505.8623 238.8627 ] >> endobj 39 0 obj << /Type /Action /S /URI /URI (http://kiwi.cs.dal.ca/GenGIS) >> endobj 40 0 obj << /Type /Annot /Subtype /Link /A 41 0 R /Border [0 0 0] /H /I /Rect [ 514.5300 228.9421 525.3720 238.8627 ] >> endobj 41 0 obj << /Type /Action >> endobj 42 0 obj << /Type /Annot /Subtype /Link /A 43 0 R /Border [0 0 0] /H /I /Rect [ 525.3720 228.9421 536.2140 238.8627 ] >> endobj 43 0 obj << /Type /Action >> endobj 44 0 obj << /Type /Annot /Subtype /Link /A 45 0 R /Border [0 0 0] /H /I /Rect [ 165.5288 217.0373 305.3438 226.9580 ] >> endobj 45 0 obj << /Type /Action /S /URI /URI (http://ratite.cs.dal.ca/SeqMonitor) >> endobj 46 0 obj << /Type /Annot /Subtype /Link /A 47 0 R /Border [0 0 0] /H /I /Rect [ 15.0000 716.1516 540.6510 736.9416 ] >> endobj 47 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/article/seqmonitor-influenza-analysis-pipeline-and-visualization/) >> endobj 48 0 obj << /Type /Annot /Subtype /Link /A 49 0 R /Border [0 0 0] /H /I /Rect [ 26.2500 687.2933 112.9373 697.2140 ] >> endobj 49 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/author/normanmacdonald/) >> endobj 50 0 obj << /Type /Annot /Subtype /Link /A 51 0 R /Border [0 0 0] /H /I /Rect [ 118.3583 687.2933 185.0093 697.2140 ] >> endobj 51 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/author/donovanparks/) >> endobj 52 0 obj << /Type /Annot /Subtype /Link /A 53 0 R /Border [0 0 0] /H /I /Rect [ 190.4303 687.2933 246.7852 697.2140 ] >> endobj 53 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/author/robertbeiko/) >> endobj 54 0 obj << /Type /Annot /Subtype /Link /A 55 0 R /Border [0 0 0] /H /I /Rect [ 136.2495 450.7276 147.0915 460.6482 ] >> endobj 55 0 obj << /Type /Action >> endobj 56 0 obj << /Type /Annot /Subtype /Link /A 57 0 R /Border [0 0 0] /H /I /Rect [ 147.0915 450.7276 157.9335 460.6482 ] >> endobj 57 0 obj << /Type /Action >> endobj 58 0 obj << /Type /Annot /Subtype /Link /A 59 0 R /Border [0 0 0] /H /I /Rect [ 551.9310 450.7276 562.7730 460.6482 ] >> endobj 59 0 obj << /Type /Action >> endobj 60 0 obj << /Type /Annot /Subtype /Link /A 61 0 R /Border [0 0 0] /H /I /Rect [ 190.9567 426.9181 201.7988 436.8387 ] >> endobj 61 0 obj << /Type /Action >> endobj 62 0 obj << /Type /Annot /Subtype /Link /A 63 0 R /Border [0 0 0] /H /I /Rect [ 104.2793 371.7991 115.1213 381.7197 ] >> endobj 63 0 obj << /Type /Action >> endobj 64 0 obj << /Type /Annot /Subtype /Link /A 65 0 R /Border [0 0 0] /H /I /Rect [ 26.2500 359.8943 209.9595 369.8150 ] >> endobj 65 0 obj << /Type /Action /S /URI /URI (http://influenza.nhri.org.tw/ATIVS/index.jsp) >> endobj 66 0 obj << /Type /Annot /Subtype /Link /A 67 0 R /Border [0 0 0] /H /I /Rect [ 218.6273 359.8943 229.4693 369.8150 ] >> endobj 67 0 obj << /Type /Action >> endobj 68 0 obj << /Type /Annot /Subtype /Link /A 69 0 R /Border [0 0 0] /H /I /Rect [ 449.4683 300.3706 560.0138 310.2912 ] >> endobj 69 0 obj << /Type /Action /S /URI /URI (http://www.geonames.org/) >> endobj 70 0 obj << /Type /Annot /Subtype /Link /A 71 0 R /Border [0 0 0] /H /I /Rect [ 386.1030 228.9421 505.8623 238.8627 ] >> endobj 71 0 obj << /Type /Action /S /URI /URI (http://kiwi.cs.dal.ca/GenGIS) >> endobj 72 0 obj << /Type /Annot /Subtype /Link /A 73 0 R /Border [0 0 0] /H /I /Rect [ 514.5300 228.9421 525.3720 238.8627 ] >> endobj 73 0 obj << /Type /Action >> endobj 74 0 obj << /Type /Annot /Subtype /Link /A 75 0 R /Border [0 0 0] /H /I /Rect [ 525.3720 228.9421 536.2140 238.8627 ] >> endobj 75 0 obj << /Type /Action >> endobj 76 0 obj << /Type /Annot /Subtype /Link /A 77 0 R /Border [0 0 0] /H /I /Rect [ 165.5288 217.0373 305.3438 226.9580 ] >> endobj 77 0 obj << /Type /Action /S /URI /URI (http://ratite.cs.dal.ca/SeqMonitor) >> endobj 78 0 obj << /Type /Annot /Subtype /Link /A 79 0 R /Border [0 0 0] /H /I /Rect [ 15.0000 716.1516 540.6510 736.9416 ] >> endobj 79 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/article/seqmonitor-influenza-analysis-pipeline-and-visualization/) >> endobj 80 0 obj << /Type /Annot /Subtype /Link /A 81 0 R /Border [0 0 0] /H /I /Rect [ 26.2500 687.2933 112.9373 697.2140 ] >> endobj 81 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/author/normanmacdonald/) >> endobj 82 0 obj << /Type /Annot /Subtype /Link /A 83 0 R /Border [0 0 0] /H /I /Rect [ 118.3583 687.2933 185.0093 697.2140 ] >> endobj 83 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/author/donovanparks/) >> endobj 84 0 obj << /Type /Annot /Subtype /Link /A 85 0 R /Border [0 0 0] /H /I /Rect [ 190.4303 687.2933 246.7852 697.2140 ] >> endobj 85 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/author/robertbeiko/) >> endobj 86 0 obj << /Type /Annot /Subtype /Link /A 87 0 R /Border [0 0 0] /H /I /Rect [ 136.2495 450.7276 147.0915 460.6482 ] >> endobj 87 0 obj << /Type /Action >> endobj 88 0 obj << /Type /Annot /Subtype /Link /A 89 0 R /Border [0 0 0] /H /I /Rect [ 147.0915 450.7276 157.9335 460.6482 ] >> endobj 89 0 obj << /Type /Action >> endobj 90 0 obj << /Type /Annot /Subtype /Link /A 91 0 R /Border [0 0 0] /H /I /Rect [ 551.9310 450.7276 562.7730 460.6482 ] >> endobj 91 0 obj << /Type /Action >> endobj 92 0 obj << /Type /Annot /Subtype /Link /A 93 0 R /Border [0 0 0] /H /I /Rect [ 190.9567 426.9181 201.7988 436.8387 ] >> endobj 93 0 obj << /Type /Action >> endobj 94 0 obj << /Type /Annot /Subtype /Link /A 95 0 R /Border [0 0 0] /H /I /Rect [ 104.2793 371.7991 115.1213 381.7197 ] >> endobj 95 0 obj << /Type /Action >> endobj 96 0 obj << /Type /Annot /Subtype /Link /A 97 0 R /Border [0 0 0] /H /I /Rect [ 26.2500 359.8943 209.9595 369.8150 ] >> endobj 97 0 obj << /Type /Action /S /URI /URI (http://influenza.nhri.org.tw/ATIVS/index.jsp) >> endobj 98 0 obj << /Type /Annot /Subtype /Link /A 99 0 R /Border [0 0 0] /H /I /Rect [ 218.6273 359.8943 229.4693 369.8150 ] >> endobj 99 0 obj << /Type /Action >> endobj 100 0 obj << /Type /Annot /Subtype /Link /A 101 0 R /Border [0 0 0] /H /I /Rect [ 449.4683 300.3706 560.0138 310.2912 ] >> endobj 101 0 obj << /Type /Action /S /URI /URI (http://www.geonames.org/) >> endobj 102 0 obj << /Type /Annot /Subtype /Link /A 103 0 R /Border [0 0 0] /H /I /Rect [ 386.1030 228.9421 505.8623 238.8627 ] >> endobj 103 0 obj << /Type /Action /S /URI /URI (http://kiwi.cs.dal.ca/GenGIS) >> endobj 104 0 obj << /Type /Annot /Subtype /Link /A 105 0 R /Border [0 0 0] /H /I /Rect [ 514.5300 228.9421 525.3720 238.8627 ] >> endobj 105 0 obj << /Type /Action >> endobj 106 0 obj << /Type /Annot /Subtype /Link /A 107 0 R /Border [0 0 0] /H /I /Rect [ 525.3720 228.9421 536.2140 238.8627 ] >> endobj 107 0 obj << /Type /Action >> endobj 108 0 obj << /Type /Annot /Subtype /Link /A 109 0 R /Border [0 0 0] /H /I /Rect [ 165.5288 217.0373 305.3438 226.9580 ] >> endobj 109 0 obj << /Type /Action /S /URI /URI (http://ratite.cs.dal.ca/SeqMonitor) >> endobj 110 0 obj << /Type /Page /Parent 3 0 R /Annots [ 112 0 R 114 0 R 116 0 R 118 0 R 120 0 R 122 0 R 124 0 R 126 0 R 128 0 R ] /Contents 111 0 R >> endobj 111 0 obj << /Length 28615 >> stream 0.271 0.267 0.267 rg q 15.000 26.524 577.500 750.476 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(All of the code developed for this pipeline was written in Python, using the Biopython library version 1.5 )] TJ ET 0.267 0.267 0.267 rg BT 472.254 767.476 Td /F1 9.8 Tf [([9])] TJ ET 0.271 0.267 0.267 rg BT 483.096 767.476 Td /F1 9.8 Tf [( . The data )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(warehouse is managed by MySQL version 5.1.29. The web interface is implemented with the Django Python web framework )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(version 1.0. The system is composed of two main modules. The pipeline module parses and integrates sequence and location )] TJ ET BT 26.250 731.762 Td /F1 9.8 Tf [(data from the NCBI GenBank and Geonames.org. The visualization and analysis module allows the results of the pipeline to be )] TJ ET BT 26.250 719.857 Td /F1 9.8 Tf [(explored through the web and compared with user submitted sequences.)] TJ ET BT 26.250 700.452 Td /F4 9.8 Tf [(Pipeline Parser)] TJ ET BT 26.250 681.048 Td /F1 9.8 Tf [(In the parsing step, the pipeline extracts the location, date of collection, antiviral resistance tags, S-OIV outbreak inclusion, as )] TJ ET BT 26.250 669.143 Td /F1 9.8 Tf [(well as each of the standard sequence identifiers \(i.e. GI number, accessions\). S-OIV outbreak inclusion is determined by the )] TJ ET BT 26.250 657.238 Td /F1 9.8 Tf [(2009 H1N1 Flu Outbreak NCBI project number, 37813. Due to the relatively unstructured format of the data, location, date of )] TJ ET BT 26.250 645.333 Td /F1 9.8 Tf [(collection, and antiviral resistance information can be defined in different formats in various blocks. The EpiFlu or FluData block )] TJ ET BT 26.250 633.429 Td /F1 9.8 Tf [(is checked first and is considered as the authority for each metadata field. If this block or some of the metadata cannot be )] TJ ET BT 26.250 621.524 Td /F1 9.8 Tf [(found, then other fields in the record are searched, such as the source feature block, or within the free-text notes. As much )] TJ ET BT 26.250 609.619 Td /F1 9.8 Tf [(information about the date of collection is extracted from the record as possible. If complete collection date is not available, then )] TJ ET BT 26.250 597.714 Td /F1 9.8 Tf [(just the month or year may be extracted. If none of these fields is present within the record, year of collection is parsed from the )] TJ ET BT 26.250 585.810 Td /F1 9.8 Tf [(strain identifier itself.)] TJ ET BT 26.250 566.405 Td /F1 9.8 Tf [(Often, antiviral resistance information is provided in a human-readable format in a free-text notes field. This field is automatically )] TJ ET BT 26.250 554.500 Td /F1 9.8 Tf [(parsed by splitting the notes fields on commas and semi-colons, then looking for the terms adamantane, oseltamivir or )] TJ ET BT 26.250 542.595 Td /F1 9.8 Tf [(zanamivir. If exactly one of those terms appears in a clause, then that clause is searched for sensitive or resistant, and the )] TJ ET BT 26.250 530.691 Td /F1 9.8 Tf [(resulting information is stored. If conflicting information is found within a clause due to a parsing error \(i.e. both sensitive and )] TJ ET BT 26.250 518.786 Td /F1 9.8 Tf [(resistant terms found, or more than one antiviral specified\), then the information is ignored. There are multiple cases, such as )] TJ ET BT 26.250 506.881 Td /F1 9.8 Tf [(with A/Philippines/1279/2006, where more information is contained within publications on antiviral resistance that cannot )] TJ ET BT 26.250 494.976 Td /F1 9.8 Tf [(currently be interpreted by the pipeline parser, and is thus ignored. In other cases, typos such as resitant are present, and )] TJ ET BT 26.250 483.072 Td /F1 9.8 Tf [(currently not interpreted by the pipeline parser. Factoring in such information would currently require human intervention.)] TJ ET BT 26.250 463.667 Td /F4 9.8 Tf [(Pipeline Geotagging)] TJ ET BT 26.250 444.262 Td /F1 9.8 Tf [(Location information is also sought first from the EpiFlu or FluData block in the comments section, then from the source feature )] TJ ET BT 26.250 432.357 Td /F1 9.8 Tf [(block, and finally inferred from the strain name. Often, particularly with older sequences, more precise information is given in the )] TJ ET BT 26.250 420.453 Td /F1 9.8 Tf [(strain name, with only country being provided in the source feature block, if present at all. Other times, more specific location )] TJ ET BT 26.250 408.548 Td /F1 9.8 Tf [(information is provided within the record than within the strain name, such as with many recent samples from the USA which )] TJ ET BT 26.250 396.643 Td /F1 9.8 Tf [(contain county information in addition to state. The parser makes a decision based on the number of words inside the feature )] TJ ET BT 26.250 384.738 Td /F1 9.8 Tf [(block to use either the strain location identifier or the country identifier when looking up latitude and longitude. If an exact match )] TJ ET BT 26.250 372.834 Td /F1 9.8 Tf [(has been found within the existing database on each of the location fields, then the query sequence is automatically tagged with )] TJ ET BT 26.250 360.929 Td /F1 9.8 Tf [(the existing information; otherwise, the query is submitted to the GeoNames webservice. The top ten results are then provided )] TJ ET BT 26.250 349.024 Td /F1 9.8 Tf [(to the user to choose the one that matches the current sequence. Users can also send their own query to the GeoNames )] TJ ET BT 26.250 337.119 Td /F1 9.8 Tf [(webservice if none of the records is appropriate. Since only 872 of the 6857 strains initially considered had potentially distinct )] TJ ET BT 26.250 325.215 Td /F1 9.8 Tf [(country and strain location fields, geotagging all 6857 sequences with this semi-automated system took approximately 2 hours, )] TJ ET BT 26.250 313.310 Td /F1 9.8 Tf [(which is approximately one sequence each second, or one distinct sequence every ten seconds. This includes time for the )] TJ ET BT 26.250 301.405 Td /F1 9.8 Tf [(system to query Geonames, time to manually look up some sequences in other data sources such as original publications or the )] TJ ET BT 26.250 289.500 Td /F1 9.8 Tf [(Influenza Virus Resource when the place name is ambiguous, to find correct spellings when typos occur in names, and to look )] TJ ET BT 26.250 277.596 Td /F1 9.8 Tf [(up additional information with services such as Google Earth when GeoNames.org could not find the place name. Google Earth )] TJ ET BT 26.250 265.691 Td /F1 9.8 Tf [(was sometimes needed with sequences from locations around Perth in Western Australia, which does not appear to be well )] TJ ET BT 26.250 253.786 Td /F1 9.8 Tf [(supported in the current version of GeoNames. If an ambiguous place name could not be resolved, the sequence was attributed )] TJ ET BT 26.250 241.881 Td /F1 9.8 Tf [(solely to the country of origin, which is provided for almost all sequences by the NCBI Influenza Virus Resource. Without this )] TJ ET BT 26.250 229.977 Td /F1 9.8 Tf [(semi-automated parser and tagging system, it would take approximately 143 person-hours to manually geotag this dataset )] TJ ET BT 26.250 218.072 Td /F1 9.8 Tf [(based on a conservative estimate of 30 seconds to manually geo-tag each record. Keeping the system up-to-date is )] TJ ET BT 26.250 206.167 Td /F1 9.8 Tf [(manageable as most sequence location fields are not distinct from previously tagged sequences and thus can be automatically )] TJ ET BT 26.250 194.262 Td /F1 9.8 Tf [(geotagged.)] TJ ET BT 26.250 174.858 Td /F4 9.8 Tf [(Pipeline Sequence alignment and polymorphism detection)] TJ ET BT 26.250 155.453 Td /F1 9.8 Tf [(After parsing the full GenBank records of each sequence, amino acid alignments of homologous sequences are constructed )] TJ ET BT 26.250 143.548 Td /F1 9.8 Tf [(using MUSCLE version 3.6 )] TJ ET 0.267 0.267 0.267 rg BT 146.000 143.548 Td /F1 9.8 Tf [([10])] TJ ET 0.271 0.267 0.267 rg BT 162.262 143.548 Td /F1 9.8 Tf [( with an increased gap opening penalty of 20 to eliminate incorrect insertion and deletion )] TJ ET BT 26.250 131.643 Td /F1 9.8 Tf [(artifacts due to partial sequences. The alignments are then examined manually and cleaned of any artifacts, such as )] TJ ET BT 26.250 119.739 Td /F1 9.8 Tf [(superfluous terminal gaps and non-homologous regions extending beyond the coding region. The HA alignment contains 567 )] TJ ET BT 26.250 107.834 Td /F1 9.8 Tf [(amino acids and the NA alignment contains 470 amino acids.)] TJ ET BT 26.250 88.429 Td /F1 9.8 Tf [(As we need to be able to efficiently query polymorphisms according to various query dimensions, we have constructed a simple )] TJ ET BT 26.250 76.524 Td /F1 9.8 Tf [(star-schema data warehouse to contain our polymorphism information )] TJ ET 0.267 0.267 0.267 rg BT 330.781 76.524 Td /F1 9.8 Tf [([11])] TJ ET 0.271 0.267 0.267 rg BT 347.044 76.524 Td /F1 9.8 Tf [( . In the current version of SeqMonitor, this data )] TJ ET BT 26.250 64.620 Td /F1 9.8 Tf [(warehouse has four available dimension tables for collection date, resistance, polymorphic character and location, along with a )] TJ ET BT 26.250 52.715 Td /F1 9.8 Tf [(single fact table on polymorphisms. We also include the alignment position, S-OIV inclusion flag, and GI number for searching. )] TJ ET BT 26.250 40.810 Td /F1 9.8 Tf [(Although often with data warehouses we do not want to keep individual identifiers such as GI, in this case the GI is useful for )] TJ ET Q q 15.000 26.524 577.500 750.476 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(All of the code developed for this pipeline was written in Python, using the Biopython library version 1.5 )] TJ ET 0.267 0.267 0.267 rg BT 472.254 767.476 Td /F1 9.8 Tf [([9])] TJ ET 0.271 0.267 0.267 rg BT 483.096 767.476 Td /F1 9.8 Tf [( . The data )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(warehouse is managed by MySQL version 5.1.29. The web interface is implemented with the Django Python web framework )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(version 1.0. The system is composed of two main modules. The pipeline module parses and integrates sequence and location )] TJ ET BT 26.250 731.762 Td /F1 9.8 Tf [(data from the NCBI GenBank and Geonames.org. The visualization and analysis module allows the results of the pipeline to be )] TJ ET BT 26.250 719.857 Td /F1 9.8 Tf [(explored through the web and compared with user submitted sequences.)] TJ ET BT 26.250 700.452 Td /F4 9.8 Tf [(Pipeline Parser)] TJ ET BT 26.250 681.048 Td /F1 9.8 Tf [(In the parsing step, the pipeline extracts the location, date of collection, antiviral resistance tags, S-OIV outbreak inclusion, as )] TJ ET BT 26.250 669.143 Td /F1 9.8 Tf [(well as each of the standard sequence identifiers \(i.e. GI number, accessions\). S-OIV outbreak inclusion is determined by the )] TJ ET BT 26.250 657.238 Td /F1 9.8 Tf [(2009 H1N1 Flu Outbreak NCBI project number, 37813. Due to the relatively unstructured format of the data, location, date of )] TJ ET BT 26.250 645.333 Td /F1 9.8 Tf [(collection, and antiviral resistance information can be defined in different formats in various blocks. The EpiFlu or FluData block )] TJ ET BT 26.250 633.429 Td /F1 9.8 Tf [(is checked first and is considered as the authority for each metadata field. If this block or some of the metadata cannot be )] TJ ET BT 26.250 621.524 Td /F1 9.8 Tf [(found, then other fields in the record are searched, such as the source feature block, or within the free-text notes. As much )] TJ ET BT 26.250 609.619 Td /F1 9.8 Tf [(information about the date of collection is extracted from the record as possible. If complete collection date is not available, then )] TJ ET BT 26.250 597.714 Td /F1 9.8 Tf [(just the month or year may be extracted. If none of these fields is present within the record, year of collection is parsed from the )] TJ ET BT 26.250 585.810 Td /F1 9.8 Tf [(strain identifier itself.)] TJ ET BT 26.250 566.405 Td /F1 9.8 Tf [(Often, antiviral resistance information is provided in a human-readable format in a free-text notes field. This field is automatically )] TJ ET BT 26.250 554.500 Td /F1 9.8 Tf [(parsed by splitting the notes fields on commas and semi-colons, then looking for the terms adamantane, oseltamivir or )] TJ ET BT 26.250 542.595 Td /F1 9.8 Tf [(zanamivir. If exactly one of those terms appears in a clause, then that clause is searched for sensitive or resistant, and the )] TJ ET BT 26.250 530.691 Td /F1 9.8 Tf [(resulting information is stored. If conflicting information is found within a clause due to a parsing error \(i.e. both sensitive and )] TJ ET BT 26.250 518.786 Td /F1 9.8 Tf [(resistant terms found, or more than one antiviral specified\), then the information is ignored. There are multiple cases, such as )] TJ ET BT 26.250 506.881 Td /F1 9.8 Tf [(with A/Philippines/1279/2006, where more information is contained within publications on antiviral resistance that cannot )] TJ ET BT 26.250 494.976 Td /F1 9.8 Tf [(currently be interpreted by the pipeline parser, and is thus ignored. In other cases, typos such as resitant are present, and )] TJ ET BT 26.250 483.072 Td /F1 9.8 Tf [(currently not interpreted by the pipeline parser. Factoring in such information would currently require human intervention.)] TJ ET BT 26.250 463.667 Td /F4 9.8 Tf [(Pipeline Geotagging)] TJ ET BT 26.250 444.262 Td /F1 9.8 Tf [(Location information is also sought first from the EpiFlu or FluData block in the comments section, then from the source feature )] TJ ET BT 26.250 432.357 Td /F1 9.8 Tf [(block, and finally inferred from the strain name. Often, particularly with older sequences, more precise information is given in the )] TJ ET BT 26.250 420.453 Td /F1 9.8 Tf [(strain name, with only country being provided in the source feature block, if present at all. Other times, more specific location )] TJ ET BT 26.250 408.548 Td /F1 9.8 Tf [(information is provided within the record than within the strain name, such as with many recent samples from the USA which )] TJ ET BT 26.250 396.643 Td /F1 9.8 Tf [(contain county information in addition to state. The parser makes a decision based on the number of words inside the feature )] TJ ET BT 26.250 384.738 Td /F1 9.8 Tf [(block to use either the strain location identifier or the country identifier when looking up latitude and longitude. If an exact match )] TJ ET BT 26.250 372.834 Td /F1 9.8 Tf [(has been found within the existing database on each of the location fields, then the query sequence is automatically tagged with )] TJ ET BT 26.250 360.929 Td /F1 9.8 Tf [(the existing information; otherwise, the query is submitted to the GeoNames webservice. The top ten results are then provided )] TJ ET BT 26.250 349.024 Td /F1 9.8 Tf [(to the user to choose the one that matches the current sequence. Users can also send their own query to the GeoNames )] TJ ET BT 26.250 337.119 Td /F1 9.8 Tf [(webservice if none of the records is appropriate. Since only 872 of the 6857 strains initially considered had potentially distinct )] TJ ET BT 26.250 325.215 Td /F1 9.8 Tf [(country and strain location fields, geotagging all 6857 sequences with this semi-automated system took approximately 2 hours, )] TJ ET BT 26.250 313.310 Td /F1 9.8 Tf [(which is approximately one sequence each second, or one distinct sequence every ten seconds. This includes time for the )] TJ ET BT 26.250 301.405 Td /F1 9.8 Tf [(system to query Geonames, time to manually look up some sequences in other data sources such as original publications or the )] TJ ET BT 26.250 289.500 Td /F1 9.8 Tf [(Influenza Virus Resource when the place name is ambiguous, to find correct spellings when typos occur in names, and to look )] TJ ET BT 26.250 277.596 Td /F1 9.8 Tf [(up additional information with services such as Google Earth when GeoNames.org could not find the place name. Google Earth )] TJ ET BT 26.250 265.691 Td /F1 9.8 Tf [(was sometimes needed with sequences from locations around Perth in Western Australia, which does not appear to be well )] TJ ET BT 26.250 253.786 Td /F1 9.8 Tf [(supported in the current version of GeoNames. If an ambiguous place name could not be resolved, the sequence was attributed )] TJ ET BT 26.250 241.881 Td /F1 9.8 Tf [(solely to the country of origin, which is provided for almost all sequences by the NCBI Influenza Virus Resource. Without this )] TJ ET BT 26.250 229.977 Td /F1 9.8 Tf [(semi-automated parser and tagging system, it would take approximately 143 person-hours to manually geotag this dataset )] TJ ET BT 26.250 218.072 Td /F1 9.8 Tf [(based on a conservative estimate of 30 seconds to manually geo-tag each record. Keeping the system up-to-date is )] TJ ET BT 26.250 206.167 Td /F1 9.8 Tf [(manageable as most sequence location fields are not distinct from previously tagged sequences and thus can be automatically )] TJ ET BT 26.250 194.262 Td /F1 9.8 Tf [(geotagged.)] TJ ET BT 26.250 174.858 Td /F4 9.8 Tf [(Pipeline Sequence alignment and polymorphism detection)] TJ ET BT 26.250 155.453 Td /F1 9.8 Tf [(After parsing the full GenBank records of each sequence, amino acid alignments of homologous sequences are constructed )] TJ ET BT 26.250 143.548 Td /F1 9.8 Tf [(using MUSCLE version 3.6 )] TJ ET 0.267 0.267 0.267 rg BT 146.000 143.548 Td /F1 9.8 Tf [([10])] TJ ET 0.271 0.267 0.267 rg BT 162.262 143.548 Td /F1 9.8 Tf [( with an increased gap opening penalty of 20 to eliminate incorrect insertion and deletion )] TJ ET BT 26.250 131.643 Td /F1 9.8 Tf [(artifacts due to partial sequences. The alignments are then examined manually and cleaned of any artifacts, such as )] TJ ET BT 26.250 119.739 Td /F1 9.8 Tf [(superfluous terminal gaps and non-homologous regions extending beyond the coding region. The HA alignment contains 567 )] TJ ET BT 26.250 107.834 Td /F1 9.8 Tf [(amino acids and the NA alignment contains 470 amino acids.)] TJ ET BT 26.250 88.429 Td /F1 9.8 Tf [(As we need to be able to efficiently query polymorphisms according to various query dimensions, we have constructed a simple )] TJ ET BT 26.250 76.524 Td /F1 9.8 Tf [(star-schema data warehouse to contain our polymorphism information )] TJ ET 0.267 0.267 0.267 rg BT 330.781 76.524 Td /F1 9.8 Tf [([11])] TJ ET 0.271 0.267 0.267 rg BT 347.044 76.524 Td /F1 9.8 Tf [( . In the current version of SeqMonitor, this data )] TJ ET BT 26.250 64.620 Td /F1 9.8 Tf [(warehouse has four available dimension tables for collection date, resistance, polymorphic character and location, along with a )] TJ ET BT 26.250 52.715 Td /F1 9.8 Tf [(single fact table on polymorphisms. We also include the alignment position, S-OIV inclusion flag, and GI number for searching. )] TJ ET BT 26.250 40.810 Td /F1 9.8 Tf [(Although often with data warehouses we do not want to keep individual identifiers such as GI, in this case the GI is useful for )] TJ ET Q q 15.000 26.524 577.500 750.476 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(All of the code developed for this pipeline was written in Python, using the Biopython library version 1.5 )] TJ ET 0.267 0.267 0.267 rg BT 472.254 767.476 Td /F1 9.8 Tf [([9])] TJ ET 0.271 0.267 0.267 rg BT 483.096 767.476 Td /F1 9.8 Tf [( . The data )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(warehouse is managed by MySQL version 5.1.29. The web interface is implemented with the Django Python web framework )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(version 1.0. The system is composed of two main modules. The pipeline module parses and integrates sequence and location )] TJ ET BT 26.250 731.762 Td /F1 9.8 Tf [(data from the NCBI GenBank and Geonames.org. The visualization and analysis module allows the results of the pipeline to be )] TJ ET BT 26.250 719.857 Td /F1 9.8 Tf [(explored through the web and compared with user submitted sequences.)] TJ ET BT 26.250 700.452 Td /F4 9.8 Tf [(Pipeline Parser)] TJ ET BT 26.250 681.048 Td /F1 9.8 Tf [(In the parsing step, the pipeline extracts the location, date of collection, antiviral resistance tags, S-OIV outbreak inclusion, as )] TJ ET BT 26.250 669.143 Td /F1 9.8 Tf [(well as each of the standard sequence identifiers \(i.e. GI number, accessions\). S-OIV outbreak inclusion is determined by the )] TJ ET BT 26.250 657.238 Td /F1 9.8 Tf [(2009 H1N1 Flu Outbreak NCBI project number, 37813. Due to the relatively unstructured format of the data, location, date of )] TJ ET BT 26.250 645.333 Td /F1 9.8 Tf [(collection, and antiviral resistance information can be defined in different formats in various blocks. The EpiFlu or FluData block )] TJ ET BT 26.250 633.429 Td /F1 9.8 Tf [(is checked first and is considered as the authority for each metadata field. If this block or some of the metadata cannot be )] TJ ET BT 26.250 621.524 Td /F1 9.8 Tf [(found, then other fields in the record are searched, such as the source feature block, or within the free-text notes. As much )] TJ ET BT 26.250 609.619 Td /F1 9.8 Tf [(information about the date of collection is extracted from the record as possible. If complete collection date is not available, then )] TJ ET BT 26.250 597.714 Td /F1 9.8 Tf [(just the month or year may be extracted. If none of these fields is present within the record, year of collection is parsed from the )] TJ ET BT 26.250 585.810 Td /F1 9.8 Tf [(strain identifier itself.)] TJ ET BT 26.250 566.405 Td /F1 9.8 Tf [(Often, antiviral resistance information is provided in a human-readable format in a free-text notes field. This field is automatically )] TJ ET BT 26.250 554.500 Td /F1 9.8 Tf [(parsed by splitting the notes fields on commas and semi-colons, then looking for the terms adamantane, oseltamivir or )] TJ ET BT 26.250 542.595 Td /F1 9.8 Tf [(zanamivir. If exactly one of those terms appears in a clause, then that clause is searched for sensitive or resistant, and the )] TJ ET BT 26.250 530.691 Td /F1 9.8 Tf [(resulting information is stored. If conflicting information is found within a clause due to a parsing error \(i.e. both sensitive and )] TJ ET BT 26.250 518.786 Td /F1 9.8 Tf [(resistant terms found, or more than one antiviral specified\), then the information is ignored. There are multiple cases, such as )] TJ ET BT 26.250 506.881 Td /F1 9.8 Tf [(with A/Philippines/1279/2006, where more information is contained within publications on antiviral resistance that cannot )] TJ ET BT 26.250 494.976 Td /F1 9.8 Tf [(currently be interpreted by the pipeline parser, and is thus ignored. In other cases, typos such as resitant are present, and )] TJ ET BT 26.250 483.072 Td /F1 9.8 Tf [(currently not interpreted by the pipeline parser. Factoring in such information would currently require human intervention.)] TJ ET BT 26.250 463.667 Td /F4 9.8 Tf [(Pipeline Geotagging)] TJ ET BT 26.250 444.262 Td /F1 9.8 Tf [(Location information is also sought first from the EpiFlu or FluData block in the comments section, then from the source feature )] TJ ET BT 26.250 432.357 Td /F1 9.8 Tf [(block, and finally inferred from the strain name. Often, particularly with older sequences, more precise information is given in the )] TJ ET BT 26.250 420.453 Td /F1 9.8 Tf [(strain name, with only country being provided in the source feature block, if present at all. Other times, more specific location )] TJ ET BT 26.250 408.548 Td /F1 9.8 Tf [(information is provided within the record than within the strain name, such as with many recent samples from the USA which )] TJ ET BT 26.250 396.643 Td /F1 9.8 Tf [(contain county information in addition to state. The parser makes a decision based on the number of words inside the feature )] TJ ET BT 26.250 384.738 Td /F1 9.8 Tf [(block to use either the strain location identifier or the country identifier when looking up latitude and longitude. If an exact match )] TJ ET BT 26.250 372.834 Td /F1 9.8 Tf [(has been found within the existing database on each of the location fields, then the query sequence is automatically tagged with )] TJ ET BT 26.250 360.929 Td /F1 9.8 Tf [(the existing information; otherwise, the query is submitted to the GeoNames webservice. The top ten results are then provided )] TJ ET BT 26.250 349.024 Td /F1 9.8 Tf [(to the user to choose the one that matches the current sequence. Users can also send their own query to the GeoNames )] TJ ET BT 26.250 337.119 Td /F1 9.8 Tf [(webservice if none of the records is appropriate. Since only 872 of the 6857 strains initially considered had potentially distinct )] TJ ET BT 26.250 325.215 Td /F1 9.8 Tf [(country and strain location fields, geotagging all 6857 sequences with this semi-automated system took approximately 2 hours, )] TJ ET BT 26.250 313.310 Td /F1 9.8 Tf [(which is approximately one sequence each second, or one distinct sequence every ten seconds. This includes time for the )] TJ ET BT 26.250 301.405 Td /F1 9.8 Tf [(system to query Geonames, time to manually look up some sequences in other data sources such as original publications or the )] TJ ET BT 26.250 289.500 Td /F1 9.8 Tf [(Influenza Virus Resource when the place name is ambiguous, to find correct spellings when typos occur in names, and to look )] TJ ET BT 26.250 277.596 Td /F1 9.8 Tf [(up additional information with services such as Google Earth when GeoNames.org could not find the place name. Google Earth )] TJ ET BT 26.250 265.691 Td /F1 9.8 Tf [(was sometimes needed with sequences from locations around Perth in Western Australia, which does not appear to be well )] TJ ET BT 26.250 253.786 Td /F1 9.8 Tf [(supported in the current version of GeoNames. If an ambiguous place name could not be resolved, the sequence was attributed )] TJ ET BT 26.250 241.881 Td /F1 9.8 Tf [(solely to the country of origin, which is provided for almost all sequences by the NCBI Influenza Virus Resource. Without this )] TJ ET BT 26.250 229.977 Td /F1 9.8 Tf [(semi-automated parser and tagging system, it would take approximately 143 person-hours to manually geotag this dataset )] TJ ET BT 26.250 218.072 Td /F1 9.8 Tf [(based on a conservative estimate of 30 seconds to manually geo-tag each record. Keeping the system up-to-date is )] TJ ET BT 26.250 206.167 Td /F1 9.8 Tf [(manageable as most sequence location fields are not distinct from previously tagged sequences and thus can be automatically )] TJ ET BT 26.250 194.262 Td /F1 9.8 Tf [(geotagged.)] TJ ET BT 26.250 174.858 Td /F4 9.8 Tf [(Pipeline Sequence alignment and polymorphism detection)] TJ ET BT 26.250 155.453 Td /F1 9.8 Tf [(After parsing the full GenBank records of each sequence, amino acid alignments of homologous sequences are constructed )] TJ ET BT 26.250 143.548 Td /F1 9.8 Tf [(using MUSCLE version 3.6 )] TJ ET 0.267 0.267 0.267 rg BT 146.000 143.548 Td /F1 9.8 Tf [([10])] TJ ET 0.271 0.267 0.267 rg BT 162.262 143.548 Td /F1 9.8 Tf [( with an increased gap opening penalty of 20 to eliminate incorrect insertion and deletion )] TJ ET BT 26.250 131.643 Td /F1 9.8 Tf [(artifacts due to partial sequences. The alignments are then examined manually and cleaned of any artifacts, such as )] TJ ET BT 26.250 119.739 Td /F1 9.8 Tf [(superfluous terminal gaps and non-homologous regions extending beyond the coding region. The HA alignment contains 567 )] TJ ET BT 26.250 107.834 Td /F1 9.8 Tf [(amino acids and the NA alignment contains 470 amino acids.)] TJ ET BT 26.250 88.429 Td /F1 9.8 Tf [(As we need to be able to efficiently query polymorphisms according to various query dimensions, we have constructed a simple )] TJ ET BT 26.250 76.524 Td /F1 9.8 Tf [(star-schema data warehouse to contain our polymorphism information )] TJ ET 0.267 0.267 0.267 rg BT 330.781 76.524 Td /F1 9.8 Tf [([11])] TJ ET 0.271 0.267 0.267 rg BT 347.044 76.524 Td /F1 9.8 Tf [( . In the current version of SeqMonitor, this data )] TJ ET BT 26.250 64.620 Td /F1 9.8 Tf [(warehouse has four available dimension tables for collection date, resistance, polymorphic character and location, along with a )] TJ ET BT 26.250 52.715 Td /F1 9.8 Tf [(single fact table on polymorphisms. We also include the alignment position, S-OIV inclusion flag, and GI number for searching. )] TJ ET BT 26.250 40.810 Td /F1 9.8 Tf [(Although often with data warehouses we do not want to keep individual identifiers such as GI, in this case the GI is useful for )] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(2)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Influenza)] TJ ET Q endstream endobj 112 0 obj << /Type /Annot /Subtype /Link /A 113 0 R /Border [0 0 0] /H /I /Rect [ 472.2540 766.5743 483.0960 776.4950 ] >> endobj 113 0 obj << /Type /Action >> endobj 114 0 obj << /Type /Annot /Subtype /Link /A 115 0 R /Border [0 0 0] /H /I /Rect [ 145.9995 142.6463 162.2625 152.5670 ] >> endobj 115 0 obj << /Type /Action >> endobj 116 0 obj << /Type /Annot /Subtype /Link /A 117 0 R /Border [0 0 0] /H /I /Rect [ 330.7815 75.6226 347.0445 85.5432 ] >> endobj 117 0 obj << /Type /Action >> endobj 118 0 obj << /Type /Annot /Subtype /Link /A 119 0 R /Border [0 0 0] /H /I /Rect [ 472.2540 766.5743 483.0960 776.4950 ] >> endobj 119 0 obj << /Type /Action >> endobj 120 0 obj << /Type /Annot /Subtype /Link /A 121 0 R /Border [0 0 0] /H /I /Rect [ 145.9995 142.6463 162.2625 152.5670 ] >> endobj 121 0 obj << /Type /Action >> endobj 122 0 obj << /Type /Annot /Subtype /Link /A 123 0 R /Border [0 0 0] /H /I /Rect [ 330.7815 75.6226 347.0445 85.5432 ] >> endobj 123 0 obj << /Type /Action >> endobj 124 0 obj << /Type /Annot /Subtype /Link /A 125 0 R /Border [0 0 0] /H /I /Rect [ 472.2540 766.5743 483.0960 776.4950 ] >> endobj 125 0 obj << /Type /Action >> endobj 126 0 obj << /Type /Annot /Subtype /Link /A 127 0 R /Border [0 0 0] /H /I /Rect [ 145.9995 142.6463 162.2625 152.5670 ] >> endobj 127 0 obj << /Type /Action >> endobj 128 0 obj << /Type /Annot /Subtype /Link /A 129 0 R /Border [0 0 0] /H /I /Rect [ 330.7815 75.6226 347.0445 85.5432 ] >> endobj 129 0 obj << /Type /Action >> endobj 130 0 obj << /Type /Page /Parent 3 0 R /Annots [ 132 0 R 134 0 R 136 0 R 140 0 R 142 0 R 144 0 R 148 0 R 150 0 R 152 0 R ] /Contents 131 0 R >> endobj 131 0 obj << /Length 16089 >> stream 0.271 0.267 0.267 rg q 15.000 77.551 577.500 699.449 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(excluding sequences from our analysis that are exactly identical to a query sequence. In all, 3,085,598 records are present in )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(our fact table, which is equal to every unique combination of searchable dimension values, without terminal gaps. Hierarchical )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(searching is also supported, such as searching on region, country, or continent in the location dimension.)] TJ ET BT 26.250 724.262 Td /F4 9.8 Tf [(Web application GeoLocationBLAST \(GLBLAST\))] TJ ET BT 26.250 704.857 Td /F1 9.8 Tf [(The second module of SeqMonitor is the visualization and analysis module which allows the results of the pipeline to be )] TJ ET BT 26.250 692.952 Td /F1 9.8 Tf [(explored through the web and compared with user submitted sequences. Users may either search the database for a sequence )] TJ ET BT 26.250 681.048 Td /F1 9.8 Tf [(on any of the metadata fields, or they can submit their own FASTA formatted sequence to the server. On submission, BLAST is )] TJ ET BT 26.250 669.143 Td /F1 9.8 Tf [(run on the sequence using the default E-value of 10 and at most the top 100 matches retrieved. Low-complexity filtering is )] TJ ET BT 26.250 657.238 Td /F1 9.8 Tf [(turned off on the BLAST query due to the high similarity of the sequences. The temporal and spatial distributions of the top )] TJ ET BT 26.250 645.333 Td /F1 9.8 Tf [(BLAST matches, as well as the percentage of identical amino acids are returned. The geographic distribution of BLAST results )] TJ ET BT 26.250 633.429 Td /F1 9.8 Tf [(is similar to what megx.net provides for marine microbial samples \( )] TJ ET 0.267 0.267 0.267 rg BT 316.654 633.429 Td /F1 9.8 Tf [(http://www,megx.net)] TJ ET 0.271 0.267 0.267 rg BT 404.979 633.429 Td /F1 9.8 Tf [( \) )] TJ ET 0.267 0.267 0.267 rg BT 413.647 633.429 Td /F1 9.8 Tf [([12])] TJ ET 0.271 0.267 0.267 rg BT 429.910 633.429 Td /F1 9.8 Tf [( . Identical sequences are )] TJ ET BT 26.250 621.524 Td /F1 9.8 Tf [(reported separately from the main BLAST results, and are excluded from further polymorphism analysis. The Google Maps API )] TJ ET BT 26.250 609.619 Td /F1 9.8 Tf [(version 2 is used to provide a graphical distribution of the top BLAST matches. The year and country distribution is also )] TJ ET BT 26.250 597.714 Td /F1 9.8 Tf [(provided in tabular format.)] TJ ET BT 26.250 578.310 Td /F4 9.8 Tf [(Web application Polymorphism analysis)] TJ ET BT 26.250 558.905 Td /F1 9.8 Tf [(Once the gene the query sequence is from has been identified, the user can move on to the polymorphism analysis. The query )] TJ ET BT 26.250 547.000 Td /F1 9.8 Tf [(sequence is aligned to a 5-sequence reference alignment for the given gene. Again, the Google Maps API version 2 is used, )] TJ ET BT 26.250 535.095 Td /F1 9.8 Tf [(this time with a custom genomic map provider, for displaying polymorphic sites along the genome. Users can specify groupings )] TJ ET BT 26.250 523.191 Td /F1 9.8 Tf [(based on any metadata field in the database, such as specific antiviral resistance or inclusion in the S-OIV pandemic, in order to )] TJ ET BT 26.250 511.286 Td /F1 9.8 Tf [(compare polymorphic distributions between that subset and the overall set of homologous sequences in the dataset. Unique )] TJ ET BT 26.250 499.381 Td /F1 9.8 Tf [(polymorphisms in the subset are highlighted, as well as rare \(defined as a character that occurs in less than half of the known )] TJ ET BT 26.250 487.476 Td /F1 9.8 Tf [(sequences at that position\), and polymorphic sites. Conserved positions are also easily identified by the lack of marking. From )] TJ ET BT 26.250 475.572 Td /F1 9.8 Tf [(here, individual polymorphisms within each set can be selected, and the geographic and temporal distribution will be displayed. )] TJ ET BT 26.250 463.667 Td /F1 9.8 Tf [(Sequences within the set can be downloaded for offline analysis.)] TJ ET BT 26.250 427.064 Td /F4 12.0 Tf [(Results)] TJ ET BT 26.250 407.110 Td /F4 9.8 Tf [(Example: Distribution of oseltamivir resistance in sequenced isolates)] TJ ET BT 26.250 387.705 Td /F1 9.8 Tf [(Strains of the seasonal H1N1 have recently shown increased resistance to the neuraminidase inhibiter oseltamivir . Out of the )] TJ ET BT 26.250 375.801 Td /F1 9.8 Tf [(2889 NA genes stored in our data warehouse, 275 of them have been recognized as being annotated as resistant to )] TJ ET BT 26.250 363.896 Td /F1 9.8 Tf [(oseltamivir, the earliest having been collected on 18 December 2006 in Georgia, USA \(A/Georgia/20/2006\). Of these, 6 are part )] TJ ET BT 26.250 351.991 Td /F1 9.8 Tf [(of the S-OIV outbreak, out of a total 1033 S-OIV neuraminidase sequences. These strains do not appear to be sensitive to )] TJ ET BT 26.250 340.086 Td /F1 9.8 Tf [(adamantane, but do not show resistance to zanamivir. The resistant isolates are localized to five separate countries \(Figure 1\).)] TJ ET 0.965 0.965 0.965 rg 26.250 77.551 555.000 252.655 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 330.206 m 581.250 330.206 l 581.250 329.456 l 26.250 329.456 l f q 225.000 0 0 219.000 35.250 101.456 cm /I4 Do Q q 35.250 77.551 537.000 17.905 re W n Q Q q 15.000 77.551 577.500 699.449 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(excluding sequences from our analysis that are exactly identical to a query sequence. In all, 3,085,598 records are present in )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(our fact table, which is equal to every unique combination of searchable dimension values, without terminal gaps. Hierarchical )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(searching is also supported, such as searching on region, country, or continent in the location dimension.)] TJ ET BT 26.250 724.262 Td /F4 9.8 Tf [(Web application GeoLocationBLAST \(GLBLAST\))] TJ ET BT 26.250 704.857 Td /F1 9.8 Tf [(The second module of SeqMonitor is the visualization and analysis module which allows the results of the pipeline to be )] TJ ET BT 26.250 692.952 Td /F1 9.8 Tf [(explored through the web and compared with user submitted sequences. Users may either search the database for a sequence )] TJ ET BT 26.250 681.048 Td /F1 9.8 Tf [(on any of the metadata fields, or they can submit their own FASTA formatted sequence to the server. On submission, BLAST is )] TJ ET BT 26.250 669.143 Td /F1 9.8 Tf [(run on the sequence using the default E-value of 10 and at most the top 100 matches retrieved. Low-complexity filtering is )] TJ ET BT 26.250 657.238 Td /F1 9.8 Tf [(turned off on the BLAST query due to the high similarity of the sequences. The temporal and spatial distributions of the top )] TJ ET BT 26.250 645.333 Td /F1 9.8 Tf [(BLAST matches, as well as the percentage of identical amino acids are returned. The geographic distribution of BLAST results )] TJ ET BT 26.250 633.429 Td /F1 9.8 Tf [(is similar to what megx.net provides for marine microbial samples \( )] TJ ET 0.267 0.267 0.267 rg BT 316.654 633.429 Td /F1 9.8 Tf [(http://www,megx.net)] TJ ET 0.271 0.267 0.267 rg BT 404.979 633.429 Td /F1 9.8 Tf [( \) )] TJ ET 0.267 0.267 0.267 rg BT 413.647 633.429 Td /F1 9.8 Tf [([12])] TJ ET 0.271 0.267 0.267 rg BT 429.910 633.429 Td /F1 9.8 Tf [( . Identical sequences are )] TJ ET BT 26.250 621.524 Td /F1 9.8 Tf [(reported separately from the main BLAST results, and are excluded from further polymorphism analysis. The Google Maps API )] TJ ET BT 26.250 609.619 Td /F1 9.8 Tf [(version 2 is used to provide a graphical distribution of the top BLAST matches. The year and country distribution is also )] TJ ET BT 26.250 597.714 Td /F1 9.8 Tf [(provided in tabular format.)] TJ ET BT 26.250 578.310 Td /F4 9.8 Tf [(Web application Polymorphism analysis)] TJ ET BT 26.250 558.905 Td /F1 9.8 Tf [(Once the gene the query sequence is from has been identified, the user can move on to the polymorphism analysis. The query )] TJ ET BT 26.250 547.000 Td /F1 9.8 Tf [(sequence is aligned to a 5-sequence reference alignment for the given gene. Again, the Google Maps API version 2 is used, )] TJ ET BT 26.250 535.095 Td /F1 9.8 Tf [(this time with a custom genomic map provider, for displaying polymorphic sites along the genome. Users can specify groupings )] TJ ET BT 26.250 523.191 Td /F1 9.8 Tf [(based on any metadata field in the database, such as specific antiviral resistance or inclusion in the S-OIV pandemic, in order to )] TJ ET BT 26.250 511.286 Td /F1 9.8 Tf [(compare polymorphic distributions between that subset and the overall set of homologous sequences in the dataset. Unique )] TJ ET BT 26.250 499.381 Td /F1 9.8 Tf [(polymorphisms in the subset are highlighted, as well as rare \(defined as a character that occurs in less than half of the known )] TJ ET BT 26.250 487.476 Td /F1 9.8 Tf [(sequences at that position\), and polymorphic sites. Conserved positions are also easily identified by the lack of marking. From )] TJ ET BT 26.250 475.572 Td /F1 9.8 Tf [(here, individual polymorphisms within each set can be selected, and the geographic and temporal distribution will be displayed. )] TJ ET BT 26.250 463.667 Td /F1 9.8 Tf [(Sequences within the set can be downloaded for offline analysis.)] TJ ET BT 26.250 427.064 Td /F4 12.0 Tf [(Results)] TJ ET BT 26.250 407.110 Td /F4 9.8 Tf [(Example: Distribution of oseltamivir resistance in sequenced isolates)] TJ ET BT 26.250 387.705 Td /F1 9.8 Tf [(Strains of the seasonal H1N1 have recently shown increased resistance to the neuraminidase inhibiter oseltamivir . Out of the )] TJ ET BT 26.250 375.801 Td /F1 9.8 Tf [(2889 NA genes stored in our data warehouse, 275 of them have been recognized as being annotated as resistant to )] TJ ET BT 26.250 363.896 Td /F1 9.8 Tf [(oseltamivir, the earliest having been collected on 18 December 2006 in Georgia, USA \(A/Georgia/20/2006\). Of these, 6 are part )] TJ ET BT 26.250 351.991 Td /F1 9.8 Tf [(of the S-OIV outbreak, out of a total 1033 S-OIV neuraminidase sequences. These strains do not appear to be sensitive to )] TJ ET BT 26.250 340.086 Td /F1 9.8 Tf [(adamantane, but do not show resistance to zanamivir. The resistant isolates are localized to five separate countries \(Figure 1\).)] TJ ET 0.965 0.965 0.965 rg 26.250 77.551 555.000 252.655 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 330.206 m 581.250 330.206 l 581.250 329.456 l 26.250 329.456 l f q 225.000 0 0 219.000 35.250 101.456 cm /I6 Do Q q 35.250 77.551 537.000 17.905 re W n Q Q q 15.000 77.551 577.500 699.449 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(excluding sequences from our analysis that are exactly identical to a query sequence. In all, 3,085,598 records are present in )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(our fact table, which is equal to every unique combination of searchable dimension values, without terminal gaps. Hierarchical )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(searching is also supported, such as searching on region, country, or continent in the location dimension.)] TJ ET BT 26.250 724.262 Td /F4 9.8 Tf [(Web application GeoLocationBLAST \(GLBLAST\))] TJ ET BT 26.250 704.857 Td /F1 9.8 Tf [(The second module of SeqMonitor is the visualization and analysis module which allows the results of the pipeline to be )] TJ ET BT 26.250 692.952 Td /F1 9.8 Tf [(explored through the web and compared with user submitted sequences. Users may either search the database for a sequence )] TJ ET BT 26.250 681.048 Td /F1 9.8 Tf [(on any of the metadata fields, or they can submit their own FASTA formatted sequence to the server. On submission, BLAST is )] TJ ET BT 26.250 669.143 Td /F1 9.8 Tf [(run on the sequence using the default E-value of 10 and at most the top 100 matches retrieved. Low-complexity filtering is )] TJ ET BT 26.250 657.238 Td /F1 9.8 Tf [(turned off on the BLAST query due to the high similarity of the sequences. The temporal and spatial distributions of the top )] TJ ET BT 26.250 645.333 Td /F1 9.8 Tf [(BLAST matches, as well as the percentage of identical amino acids are returned. The geographic distribution of BLAST results )] TJ ET BT 26.250 633.429 Td /F1 9.8 Tf [(is similar to what megx.net provides for marine microbial samples \( )] TJ ET 0.267 0.267 0.267 rg BT 316.654 633.429 Td /F1 9.8 Tf [(http://www,megx.net)] TJ ET 0.271 0.267 0.267 rg BT 404.979 633.429 Td /F1 9.8 Tf [( \) )] TJ ET 0.267 0.267 0.267 rg BT 413.647 633.429 Td /F1 9.8 Tf [([12])] TJ ET 0.271 0.267 0.267 rg BT 429.910 633.429 Td /F1 9.8 Tf [( . Identical sequences are )] TJ ET BT 26.250 621.524 Td /F1 9.8 Tf [(reported separately from the main BLAST results, and are excluded from further polymorphism analysis. The Google Maps API )] TJ ET BT 26.250 609.619 Td /F1 9.8 Tf [(version 2 is used to provide a graphical distribution of the top BLAST matches. The year and country distribution is also )] TJ ET BT 26.250 597.714 Td /F1 9.8 Tf [(provided in tabular format.)] TJ ET BT 26.250 578.310 Td /F4 9.8 Tf [(Web application Polymorphism analysis)] TJ ET BT 26.250 558.905 Td /F1 9.8 Tf [(Once the gene the query sequence is from has been identified, the user can move on to the polymorphism analysis. The query )] TJ ET BT 26.250 547.000 Td /F1 9.8 Tf [(sequence is aligned to a 5-sequence reference alignment for the given gene. Again, the Google Maps API version 2 is used, )] TJ ET BT 26.250 535.095 Td /F1 9.8 Tf [(this time with a custom genomic map provider, for displaying polymorphic sites along the genome. Users can specify groupings )] TJ ET BT 26.250 523.191 Td /F1 9.8 Tf [(based on any metadata field in the database, such as specific antiviral resistance or inclusion in the S-OIV pandemic, in order to )] TJ ET BT 26.250 511.286 Td /F1 9.8 Tf [(compare polymorphic distributions between that subset and the overall set of homologous sequences in the dataset. Unique )] TJ ET BT 26.250 499.381 Td /F1 9.8 Tf [(polymorphisms in the subset are highlighted, as well as rare \(defined as a character that occurs in less than half of the known )] TJ ET BT 26.250 487.476 Td /F1 9.8 Tf [(sequences at that position\), and polymorphic sites. Conserved positions are also easily identified by the lack of marking. From )] TJ ET BT 26.250 475.572 Td /F1 9.8 Tf [(here, individual polymorphisms within each set can be selected, and the geographic and temporal distribution will be displayed. )] TJ ET BT 26.250 463.667 Td /F1 9.8 Tf [(Sequences within the set can be downloaded for offline analysis.)] TJ ET BT 26.250 427.064 Td /F4 12.0 Tf [(Results)] TJ ET BT 26.250 407.110 Td /F4 9.8 Tf [(Example: Distribution of oseltamivir resistance in sequenced isolates)] TJ ET BT 26.250 387.705 Td /F1 9.8 Tf [(Strains of the seasonal H1N1 have recently shown increased resistance to the neuraminidase inhibiter oseltamivir . Out of the )] TJ ET BT 26.250 375.801 Td /F1 9.8 Tf [(2889 NA genes stored in our data warehouse, 275 of them have been recognized as being annotated as resistant to )] TJ ET BT 26.250 363.896 Td /F1 9.8 Tf [(oseltamivir, the earliest having been collected on 18 December 2006 in Georgia, USA \(A/Georgia/20/2006\). Of these, 6 are part )] TJ ET BT 26.250 351.991 Td /F1 9.8 Tf [(of the S-OIV outbreak, out of a total 1033 S-OIV neuraminidase sequences. These strains do not appear to be sensitive to )] TJ ET BT 26.250 340.086 Td /F1 9.8 Tf [(adamantane, but do not show resistance to zanamivir. The resistant isolates are localized to five separate countries \(Figure 1\).)] TJ ET 0.965 0.965 0.965 rg 26.250 77.551 555.000 252.655 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 330.206 m 581.250 330.206 l 581.250 329.456 l 26.250 329.456 l f q 225.000 0 0 219.000 35.250 101.456 cm /I8 Do Q q 35.250 77.551 537.000 17.905 re W n Q Q q 225.000 0 0 219.000 35.250 101.456 cm /I10 Do Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(3)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Influenza)] TJ ET Q endstream endobj 132 0 obj << /Type /Annot /Subtype /Link /A 133 0 R /Border [0 0 0] /H /I /Rect [ 316.6538 632.5268 404.9790 642.4474 ] >> endobj 133 0 obj << /Type /Action /S /URI /URI (http://www.megx.net) >> endobj 134 0 obj << /Type /Annot /Subtype /Link /A 135 0 R /Border [0 0 0] /H /I /Rect [ 413.6467 632.5268 429.9097 642.4474 ] >> endobj 135 0 obj << /Type /Action >> endobj 136 0 obj << /Type /Annot /Subtype /Link /A 137 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 101.4555 260.2500 320.4555 ] >> endobj 137 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/09/soivoseltamivir.png) >> endobj 138 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 292 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 300 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 613>> stream xA 0 =fy9뀟\cz~ endstream endobj 139 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 292 /SMask 138 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 300 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 97415>> stream xi%Q qNnwj_nuK-%dIwlm0ߘlc`00lÀrk_zVo7f{ }Gu8q"Dĉs2FDqM" [&](,1zaW{RH:(م(;vwy'GBvvwo=>9 ]ح(sfv0s9ݘY1lW," 1EP'ѻe'a;BMpN*Sᣨdٱ[:(ںYE-5CJ:%ڡuqMvSN{:EUB DvF !;Q;f4JVu7=UI׎[9=خX;A9zn<ݤvttp="0(⣣t_tJtBu ܨ?bЍnt0m!w=]I:u+gQ](׻M:zzzNX&#+~/x\!箮mV;~ SՆ[3+us"G>'T7 8zE7vsܝ La^R2;x7GzQtNg{г 0)m{W}n\O4L·Wv0m 粣.w:cu m݌D[7L`Oȝx `zqg']?/9Ss~;`ksyݿi:*//|aD^Y_lܕ;k_|㹟h=*cS|>kʧ'o94Cȷ^}y Z6+~跉HH9Oێpici znZ7M)TgW'O ?ouG~_z"}/oeH?c/ {FVrtpq cjmQG=vW(+^)drXKu/ ԫaWa9GqO㞏|x{~o?˦|?{pM~îh3~}?~.@6~v~/>#\zkަe|xW}ӏ/ʿkͧ-&$ǾVkXCoxo_7Ot~/~QW}g.=Pů̀o#y/>C~ow 0:{#[۬~1CNqQGG|{]ZObGgvMA{rѥ!LS}%S8 -'Ηdg)P_}ϛ;O=2iמ9l΋3c M"2-'҉ɷg?x>1m'LvlǕRFP[v` ϧ$|"$t{6wh@]~wc(N?4J9m/tpAR)nBGӳUiG_wu݂ކ}zuhgO%2(˅Ijn ^;,v-:G}JOڰ+~ww{s'N!zYxG _Y>=*n>ܑ#x˯}/,^_;ˋxͭ+륁\|st{x5OU]:ND<{i\vt/ģ/˵\ZHy-?೷g_{✦*c|fvi؀+Kfxx=_x7!ۮ_]*N?37xu5nw޴v~>{봢~~bp|z}wqޭ6ܳ.=]KҶJ[$'wyO9^v"NCaF#Dv-{NK*Ndtw9guNZS]xyIz.2zOCOvuz]bn򁝗 ݨz2u}zfqĀ*b 7OOxWGFz6h? i1zaG)8c38f;$駑h;$24i9 RUN;]Dnws=Fwmf'lhwlݻ I=ۓ]IJpk~wq;ARO9$q+=xMD|d+.xS/^](dz\"n|ӳ半>;Si 糋V_Y(' ·ʵSnj ]797_oZ?uWWpv.\۬4~8מy~OiXم⑩-]F?Ģ8}_yǦ|ov\%!.{:(1 =ͻ\DưϨ(`R=[DmeQ =G{UtnnʣSݚm;7\,_^X_]ʷ\Y*~ԹǞ F?6O/:ԹÅ~Kz>e3ֿcOԭ.\3VyRT[Xʩe>g곏=L2w_x|r01\Kō{~f o}!7U,վ.-gF{ő/>v1NĢS:S7.}:vK-vb~OQEPn {vGv=NSw{]dmw7ݰoētӁ1WޑG,mg hh԰42{nWʟ8\W{bzMr801K'r CD\v_6y=#D3$?wvg.gb ߜ3Můle_y|_\X٨;n8z`'C:;=^MwǗl+&:w~v߂d @3&|Iz]`H{.QJm^xN:Hpw;n_;u܅(d7pBtz [=Ӏ[E$cwRwd'^Gu>%.4q^/lIvvv7j)׮䓟mtϧ&DnF^iwK#y蝎 nvׯwD #lىbv:Et?6\^&fw:쀳Si:=cJ*T\&),ȶiy. 8807.j++x*8-.P,͑`DQ84Mz/'ؘɹl6\4T50 b~3T\8@5^DgWp1r_D;w#Da 7WBz$knƴJJ\sqD_Z;2MjHC^.W̙1 X\wʃqU %B̕-o OйmĽD\* NrciӬnvx,T17Nda\Xs;})A2u<)UƄ$tdJS @)Z}ߓ! WJ~yt  דo86הv/+T|rdxn+J2}h@;la()A"! H$4m3Tޥ3\HZWjYC '7~jb͹P:|*vp8yd!6<džc ~_V. a Q34ED"[ep-oyG7 _g{|CCCpڵ Dxhոw^vmrrr~~~bb J%5 EQReee%裏fyZ-ۖ?ocLU^ukvv`0u==i}߽cax܄}jU<_7׈j̑P|­CczNT8n6-C(r KiIdɎe)'5zt1D<8KL;9CPΐ <:Ojp1HRE T+sT/ q$uZDq0ypu ǣ-1t<" L l$7?ת/Η ,)7h{(K-Hr- mqlݸ7[iY(rƲGV.οBe+h7V hN=Ӄ_=Rٸ\i8s4GĦjȵQ,*M'ӢG2{'{¡B9kkkgΜRΦRC?bxbwsN D|ǯ^SOu]_ߟ,?sw|w.wϗ.]) Rijjjss3 !N81==tR XuJk o?g>j\zLQ'._ʩT 3 p誹R3 kUǜH\\^pw^+ 4] 9)Ε59GCQ|($5]4USO$'6,O*CBΰ/a0$MZ4Oj$9')R:|Zt-GT ԾM8_Ⱅc{כYtMQg:iǦH: nWV`<-۶ox:d` ,XEZ$ԁD"pѣ ٮL$0!= D嬐J5Sh&0ܳ3d0wfo0W"uTDYN<977799:S*cD"Lٶ=99Oi}}}[[[bÄZ%J$zkR7qD4Ms|||ffرcQȞ_zucc#۷G) ew}.\a .o+{=ܓ=Z.٬(7t??22+qTUuiii``S;T*y^6f遴$3t`b:>>I "'g|Z}t>#'snަ2-fbd:pdL#2`ܪ9^T}I6l/eh"" 2WT]b±] s+Œf?ފ=&QɴZ>2)$5ŭv9Kܶ/2=,IM-/,U]Rh2c,S8ͺ}Z98҉;~n8y2s#{ '|W|744TחGGG\r=|jr5&*c3kLBu2Xnͧ#IMC "Y(O1@MKꊡGMS_4kD'{7^\]]ǗJR^ؗtU}#gݺ`Zؐ_.OOb/٥ rtLWfʷc=tcCoHt맷ٌO 焂ō8Qɴ1l6tDRS豙bqIUH)MGa|0Iٞd\OrT8"zRjK׶*cik%EbnzmI 0)a(k{hyjfpf~f~sW49D*BTY36[(R<11_l 37Mf58,,R*X$(FC25"g]Յ&7fDZ߶'H:d 4KM'УE]BH(ۉ&-=yŔNZ pC/Z芜9|f ҖJ=dtݘl^Ww" @@vf/>KʷNotQs疪Rk[֍S+Wr+ GsCcZ˩3T/쭡بUʸ!*)IiW,J~x$ӔlR4@Ι ΄"c#$QJ\EX0!fb鈺5,P+V(+O% ê" gUSxfMglCdK[\Gq5MD Z4N]ܨ: [P*@I 2͚ng 138FٌlDq4M $덍K0!!CV+N2zRJ2T+m44Tnyrj KJ"0"Zy+( y I_jtPQd%IDD2nֵ%ϗn"[v{PM8jv,3ETJ zAtvÜ#u (Q٪;$rKOr ۗш!ޛ=S7@WkneS9y9xDtlpbUĴ~c`(>8yM7 q#GȥĭqtēRa{'JD*i-m6if C!gl!51FI]%2|JOou5)7f )#`@:mh*lnMh.(mgHA!RuP_S kH$Lו?Oo#($tU$?@eiMjk'Ur ӾzH ?׿*ŢiB! І:]StBS҆z۾t]O Gd(\Fv-}w"R@2'g` }gS0"6zT&DH յzs(ߖ1q{RJ"_ghhzO u%\oz˜'thl6%f' BJkMWSECeKHG'7B@Bjndօ I# g9 <+Fɷ\*uEȯWg(郞ڶ8D?m?mALcqVk;n-$8R2DW ;yyCEVpY@y(گcckwRPtt1D3>Qnx.u"DEY/$1@I 0逨+[a{j/>p$LJͤ\êL4 A˕/r'MLĄ/69" gLJr )U8‘!ZB#2d (kh#21M k ScYձ6jkcjѓsM;:Y-Y)5+xv"4s)4M;Ј7'!p&I<'J mXXX~[qXT+}}WHݾZYl?> Moz}&H0d4όJ)OL =i!6mϯi{$֪VRS_dؓZ =o/|<|r*qPy6hmm$AR 2 \L )붫pWʄ @)/0J3)}q#_#* Dd /[F<6E2^-m !W.^Yg@|㜙ɦӌ1u9e`,59'n`G# 3.@ZI7GɌgRJih^RWmONp!93T޴pԐu#4ݭQ lcV|! O.=}ɴcW76*/? VF`*maDB\X ,aN T֑;DD9g0DC@hmwd>%u=w郈TՓBXk BJ(H"cFc0\T9Q&{dA A+ذ,W5:gɕJ3)C۪āt,kџRRst1) !>w2_B"!`<4'olMeRR*2rbzإ~DaefۀaM ȴRJiBYi[9`R$ ^Ar1^o˰\ƒ0ks`G'3{WRliZ5;{V5 UUu]vm0[ A(1CLpuĀ ̟m^-+9`d R0S Wܾ2"2k)}ݷojjnnnxdxkk/zq}; R1DU%u#+dG 0xЕ3T<9$_L}'"Vm; !}SvO/f]!3FD7p3KT p,"/=}91߇w+?]<;f]>Oؿ'IT Z3ܲ6↹.=9mgݪdfvխPLi :kV.6UHf݉k,B&yRj SB҅|N2(΀pv1Z#I+e`/i$*5oͬTN\]o C4P|A&P@Ki7•?mhafgf׮QDFUKŔreI)eKg'JOquV7MNL1@IrnϯWd ߾Cqǝ\YY9ywIb_`;x SHjDZ[1 zB-L\K|Lhjۓx/LRfR?~ר`uܫ0 ^X.ͬKup'IdLUf֫`glXLUlOHJ ᓮrf{ MkC&#o "@JI?C@bGNml|޻^,xiY;FFF=_(! "ΘBCt8 2] E $IVk%&2$"}kv+[CՊ|yj0cݨ__2?a5ͭDߘ/@xoV{F }cŵS?hFhLB^Zt2JN/SpV۟9j.ݭgֿUޤe6_<7HDOB3?)#Jǵ[ r6eaܳE҆kfݩn{ (NQgדk\583|n2_L`f(6yH*`W8WtJ) I" | eԃ! +Lkh G4=Op/oo[ ׼0!*`\5Czmޠ2u+echj!O| 5ԟJ}aCAV9>z㞣'x6-볳s;TȋXj֛⩹ҍcٺ-l5MvoRƳy?m hnzB@^RRO` G!!\!.˳djZ)JW`Fcz F+H2@J 978omG$5PҞahiBpfW#Mnk+-VP{Y @X#v8KdL ̕i>ݹ_Jt*88=V>BR=}6_dx6|)xRplo1":{riaĤi;L$Vݑ҈#C Y"+vz8 i£6"!T\I/.X.+X3J0џet/ @xgUE=*}/F!kE$ArԈ|X?Te9d-PcJJ<֭7Lf3C-1w_sm t~Ea5=I#tB'zJҺY,WDzqlIg QC,O@BǘGAQԞz" ᑑʸ_@B %;PN@PWX:bZX5E 0 lkAcQPkl ^)Tw( Td^OZ-1/״J}^խ.6'dͭԬmHͅ '*͙^ar*$97Gbx3T2 4m.jJW)GH  6lWSp$ @0yf(ɖmbn-k{aW2m^-sHg q*P&f5C%4DV` .Xnr9rw^[WU=kNbaaI؆f( .Èq8ɠp0CS"G%B6W"ys 4tARD' yۆ} 4\o4zmq 4;֤PԨƝb *gF2g!mk97U= BKlZml7W L-Q_XXBʫkMhiZ;hk=ibщɅ^(;[MLF"1 TPD$)Y+ 31"%",%\dj_nTO廏kk 7Zo) ZZUW4 ҡ])B~}+k"qBeeO\qe%JBcS2h$^OO;LY !$%cb=SR1 SHOg H WJqWfJi \OLcAERH6-2ߜidIvvND=vm3!(ZLP&d6,٢6,my#  6(B"ġ9 5 {/y8q׬†Y7q9q0 6DE;g}*i5L"@&EQN/5'wH}|2yowPL.gZZC8l)6zFv w4댉cԗ+ôFov){ot`pasjF$kH,LHvti\EQ3a|4_[m)lomϼ MyN#-8B%T$ֹؖ9=̰KJVAB֖@n!3f.mQm\$f3Rv\)enJ=5.\ysZh4 ! 4]1 PqRcfEj5'c`$&XIF55Ewgw/+0<GW-"ΦGz}qiW pĘte9Ydw_˱ j* pL :hj2߅ۖ/C)Ђ酳8F9 &cٍ;+O~2(LO)F9YC@d?{kr[AW_aI9ؽGs?~|j- ǎcXێ9LpX82S$T Ù,a?8 .!ϾZQ69KYlxi&IiVӫ[ƙy$4'l򯐦҅Dl#Cn {ʪ E`,4O&Eێ/\ϦaHt b)j;;k4 Oj|xxڵ\I!!8 +HOR2tRƍZݱ@TJ8Vf۲'{kk$̤HsLKa۵1V*iM_&ljB8C3k'/m5Wk6fˑ̅X FR}t<~qx$"Dȿs0Jx5*xg+,J"Ip}鋝8 )se@Dm-uZ pmm]Tm)U;(9;qCNOOEP( [i㏿S|:{O~Ƌ0E{qia٦ ΅Tl1+@᪳ĕڮ^Xþ&8m?;5*VjYB `˳jiT^Djzl8kW Q[RG$RbeŔĀ%ܵt0i?ѪzhbJ+UskĿx2Yg7՚tF1d>smkԿLW^xvU=VA*i.5@Fq(NUm;#h7lдvy;u!91 b[0& TOico4Xb5T)řhj&gϽ|fGkN }]5~uqr FF2RD%uiGq`8" ɢ"H"L{:F95=l>d9L8Mb.Vx0}b#@^6=Pow>?[;2vU1` 4x-,+tdp0 jOmTW2@`J|U#?F`/W&~Jvb -ƈH*]3 IJkEZ4+jzFՆ0*՚[Fx "2LKɾ1kBū;-ɗ "@{W.\/ӫ//I`vs׻uэڥN?'i>DPjP||Ӿ΍dyn]RiV%D#McXAyr͒@:T|kzv@>23Ǔڜk jlnkvTApAZ") 6b76j{EDV8@۵p8Ӛƾs`fQd'iZ182*q8oLdOd r3b$ |'+Ԭͺ;+jUB+SZݖZ/"F9;9tRVV3F>0!CVV;x4è55.LfS.d6 psm!GXYB6gkN-iɕرM3u\jwH$Sk V!Ypj9é/?sH`Dz̪%M*MeN !硜ҏToAL$g;ih0∩`Li4-b rWa;vYK|S6dս`Jek8bאΤ@eիV<<1Glo4Fj©6VVwV=)IkkP ز|9Aۆ4ҚVk=jB"jV'v%sȢlf zh~vXnH STㅯs+H-Kfj* |u6@lԥױ7o޻zpwkc՗_m; EHI(ՠ 4" oo6xr Cp@(m4bPDTuzx6?r Ѭ瓐"m<g*vϵfrK]L'h6b`cMGh_OG٤QkLqթ*!UR)L. H%^|w|) aaE纮{GnޘΦՊWq+Hh\+mVɹ!WAtZ턩r ^ڔ,tc@dk;1XnT4 AkD0UFCap''+eDV񤒌1tʱ"w׆ɚaiceݚ8Jٸ{ J" G0d2+ӔazC„ EL ? a3B}L'nRF6͟sPs wgy[VXŸK.i}7{M^MXCK)Oh ߬[i!neG LzW,CMaBn%8p4[eb޴;nu*Atm\Qb{[uU#TǏ]׽~ڣǏ?7*t4L0^y۷׮Rk9(9t1WJ45F$̴nQk?oʯʿ?xקkժy^om}]kǓa718:x{m ~,bg_a`VRFDTF%B0D 㑔zZK`?Q{6Ostfy@I!ݻbx,R!`Tj<QO8L.-}+)kfrw+9 |sXInȀ1'R+@ E!# `\)CRѬ>@k֤`&-RZ1RQ,kh-yz͖km(=YTt2<Dz Y`6%U' X W^yl>tRk4(aCJY٪WH h{{[JVhmeqb1魧×[iQ5s[\r>x6:⥍c= .7̥n(>,"ީUn^ڋ/攬(R~~I1V>ZY5Өd{2]ʆК|%=}t +%)ED((2)QX`XGPg EȘ`0!%֊g[pf S%yE$!i PbJ+%57ĜjU++ukkrO gj7|6U/q$L2eFl1e`XozI:V7Rѩ$_? +ng&A$"T>T{,a˸wsM+˓F%HR)O \0'WT|=dղe,Ak8Ru0_,NgmEJc ۶4-C @(&ciõswSWnݟ(!5}J]C^675UVjxMU;/\2w I'!B (P$@lg]zn(ӡoW`cBñ=y ʥ@ơRclZ:g²MWhn4eōV۝ыR 0>ue N((z;0٦TZ0bP$scfq2@C00j!FBajU*~66~곟JBQVw-,;(@q==>7n\ăǻdl9&TTlKaʖP+-4 X0#? )jYE Ui 1 Y&[e )f(r~% aNL4gs8&B nBZȓ $\xBkIIlVeN˲^ڨ_Z*ERzѣOj g˳dv8_ڛ<:H:/hX`dFʔ).M`d@VRShm5@VKъɕdn_yjtbn4\V93X*Rl xp&菣?{2%&+;kZY@+ڮmrHj~V[퉚U;LkA ʛiҚ$nw<wZmm`HԫU Appz1$!)FI4QU;rs9&n]ݩ0{N7学m"RP%/)ѳ+RUTܧ.dIQNv*7'!bɞd13J*\ҽlla0s *j(L^\WD Q3f $R Ɓ4C</6;UBj{ʅ1xGFM#)ixgwk7\b % ] X%XyڥVKM4 blڒ1h7Yzp`wwݸqO&W/QQǚlCtEޣ= 'Ӌ*U2a-4݃Z1EF4KwNOm/ f[_ФwynZx炶\n\ljhWA)Nc DUjsNIKHHPRٝV' éԻ^sc[[5nsosy) `%Bd2Yzܽ{r||>8- "#+}2b:^Z5{{~|mAR?띙F if~|~x0>w>[Gh4DAKi޺rH&jzv>{jڰꮳxԖ(qFKhTw P*YTz!U=õj;/^/޸|qwWg&_Ӥ?:n/bY@[RU)+qeBB % E"sJA~:O.&so'9ܲ 8߰M3SVj}zjqΝ;QOG~VX^?[[ b_4-_37/@suvuWnno8 'A|o j?~{28'{ߏ*swDgWt}[Nplb1SP,W.Ej#) lVݖ,-lXz4#.ru!m4`gyr[IB ?N|SVhL!m[m,9]~O}jf.=ykˈ2? Cm1XKS'0p2vV+WeQc۴SCVTX,sC4mW??2 cuuӯ <;>o?k ߬~3nwVFRyhgx?=Om>ȓų#ֺsK .Rity|\dEo3ύ8w'>zm\|;+;{ .oNcj}?5X9ZF_r2Z,zfBH@fE`f>аmg?Bpdw.]<=7M{+isd^H8FD0bAW5J޹?U>" `iJi@ӧbiǦ~{wFσP>Ա"3YfI~6[Fٺz/\|nbޟD23c #֚hnqN' b^gQG%٬bRy^R٘ׯPwv.lo-8'QѪ80g㨓x>8c۲xǵ]4O{irh2L&Np8lnȯ59kxpִg4Tͪ.&W/oL7OޟJNe8ܕKnX^!L}S.K)C,JYJݪfq7cmJhT.vWvvֻzQ'ˑ[6eiB_ Dz S ! Ї3Sf(TI`Z" ّͪG'_tfC@Q/1R`E4ŵ"~|67/kZRtF|aџy4cgd ʵijb hJXE ~ɃG |w80B.PaR /U#9ͦpԪN$hC6Oy4 6VRr#X=XJ:!cpee^zǝ-P >a9=K7֭Ӄ aq}}E7v6[}aV+a, hSͿeO4E1S;WD,꟞^~0b!ce;70HZ)hR"LUiY&Vb\e lVcmVvG1 Ҟa9A@0mðpEZCD`dkk$B]QAY8oV>&rv^ܨI~7A2,+)bYoUO|cكɓ)ly+-0+UjiG~T  ?u*?Uū#bZw,w>@nJy9W^001Me,V+dr9*HIv]wH-u0,4ȴ~/b2L&Da~e4ڑھҸz|+[[[o=>~$ϓAn`LEP*j c  J4=yvο]tp>ygcs<"wfyRH>V@9@ ]o3lBr0L+CY-">朴fDZ8l9 ʕ=>n<nn_ۿW~??97?~pdE 9NT{i;fL(˞=|qcްQw}f~iQQqOOFϙ0ҪsaUpkTn؇JŶEeơ$"Emi0 *I)WJ2Z`6UDv2?< Rǎ0۫;ohNNO+^ms-f|2|aZ˭"M@h#d=۫W}}:CUB?O-d'7͗VŸ?o;Jjz~Xt}p $)?++?|睵5fifoZ hԪ~z^-xs+S?Mhڷn|ѕ"i(*NΦo=Oڵ/\vWw.׻giG|闞 @Ԭy陑V&r@RID8fbJ0+DJk lnoYZdO֝ۮfӹ?;8xio|cٳ5a l6X= p(ɶ?|Lˊhtmz])l6W]ױ7!!k#΅GDtoLERJk}{wpax؏=SQ3 &Պ۟?~:ho"-U/^~4 V?[s)CK"HLHMd_k4E9S(˨Vdr¥K0ʛwC&Y&: }vl 1j`ݞs@nAp! bLpX !b1|i,UVF9& MRȶevQ O˗YYmZO6ߧkEP:sKf˪EI ONNN=3 47|soo/Y+}ps?g/ԬvODH JPNh8MsS LJ֌2-Wh9)PlIRJ򹻁-?Õe:kӕnwO~u 5Ȑs5ѓ.(1(!EԦc) Җm)?<>88ggO>͵&˶y7U0V;Ùn?Iz `8f^8?&E8XIWa|> mDOfv$Z bE36jӓ [D`>BHK69wﮭjM+m9xL2l,.3L|4 •n(~iY|̑6!rόg~܏PE`;">byu[ʵD ȩ 8$σd̮R6z*UTZF615G*l WÂXa8ɞotlwݰN͖mZ';UF1$17o~wv/9Ȗ<=ETf]υ9Pqf(X[ibK'yH,><µww:Q˳ \˺yh2nz3΀OLh1!؇cDlzN۽w8 "̵2(KdC!k=}n)]31^ԣd a]K,BY?|ٳ%y'}}?w{э@DRVLq1p`%~s(a?8HF +n߾ٷ:燪saqno}Kei$.ffZ&0 ᳧@Vqrv^T\5<۴O DSfEZq]A"߽[Ww!|U pvr^%ĆQi^8٣jO9WeYVZ-iGIZZ폾L$ .ZEI3MQaQh|Z2z PXO޺Zn/a2/CAiPZ-6?P Ĝ7K d3 B⩚08kWn,UF%_T2٪g},Xr ~+/lcln~` GI٪td-NZ0rEGNn.˚/,:%5=d4?(xe NnwtDôVD@}c..^/zNDQrOO1B|qTz靛7 °V)Zm@g !f"~gNnݰX-Wç.;50EZNNZm~~d^1[!}맣gs΂vٺ9#Qqh(-e+rT$B۶8kʣF<̽c*Sݷed>8^1+^a,T,SSGQBP!$uS%ފ:F(|Ѿ]n`6g7BbT|Ra;5n0?pbz>^5qGtszL&NmͽgLÊc[g,-0㓮JziljFQ/4WM B2޽"]Eĭvgó^kFqh.$ixe? ` Ϟ޽}GH4+F~rqѩ d" Ƞ8oCG޽C4\W>:^̂"xm|GITadڰ6S* ZR's2-˴2^ amڎmϗ^Wr^f} 1@\{?htqnKʕ ,A*Sܹ| Lƈ!Kkj, l{ASbK% %A(CE,GrT,HbC"(&n3Fsư^ݾ};l֨ :*Uz!$33K#V^P8{6TE+/k %IW;e0IZVK~ʵbVvK%UȜ!u>赺J91ʝ2@N~x{{O?k4ȲkԻ֮:y7 qM]bU5+ΕV9YOxZ "Ce7yfw[+U8Nڭv!Vaprz[&jHŕ=ً|~u UZU|~k/7~N{+i G琦*[/Re2@t@\ /#MbY<A߁[ !R|#^XЦq(FBU_w1L!gJjl~HEӧOyB0iv%sV-GiGC?c&B卥#ewc97Ҏ̫nl8(o\md>ʐ2%-%_fvcbVΦ٨V$uJ%Ջ 1?\4M8ðh4[^W3_<9j6h6j aQۥ4j+;~@%._>ȗۏҿvgY>z=nݺJ7n|_a@ۉx0|fagbxqeg1I &fK !@{HzwĪ6گ? ӤxaHZ~.c]:5)Flh  D Jc]=%;s-wq-.:U'sӐfEYRq?aO0oVY2y>W,KBhxo>X; [A|0X]$ɒXJSO5ʩ K lKP++8r=2~#ۮ<{''Q:nTvmg47*|*^j4̵^Kv9_!g# {V`/fx>x{f=0^w_Zlֿl*"A N?8F5 Nlō7=zdy狹l`Dl>]"jzle~~XUx:]mۜ!yatƏo@(;ఐeӨFRR?/{|e-Y5'}W)7~38*Q@;R8YDqU&ɥpZ~!@@Z,c|"WHiJgΦkX+߾-ONK?.9ٲ{k#J3HHŲ7gXqMD\x 4rJȶH$#1쌧JN&Yodc q(Jh:Wa b0\^Rd[vO<}7L3 CTZ{^^+h\eDË VJ[/H=TA&.8kgY;;i.T2D~nhe2==*"LSe´4*^z0RlrΏVգǏ7y^\%I6cK% 4)'d "Z ת is@ّDKƣW]~mGQ* *鎢&AI$ "j Xc-]ܩ8o\m~r2OShW;UFh6.:ןD_LDd{[pdٳڣvU*I@5U86|$9QP$phƇyj^'I2;{ppڶgQcn|NkqO@ .>6[GZ#"hpdQʀeny>X\jNt`Q":V3/(]0"1ĉ9_l,R6|l5 14$(;xy0N > C^oI͔QD2"hD!vr=ՠ"І!r(yFm?}pTBeРNJ!Q(R& sadzqMNsUb /3| 3?L/EZ),60.wtu߸)pjX%[? 0 XDs,2R2"Ew.S2,uːUB%RѢpRW\_໯wyzsWSIu_V`` BrO/‚@3=u9I&HyŢbl}8e7: I|hz@N@y$MRrl%@,y,PI1"D<#*T8IaȀ8{^q\LϞ}Um;]xrpm .?'m;zVq e@$eHnA$%vt6cbaYH_LD.HLw27Ñwo٤ kճiCho@@?U^Jl""M/oݺzx-x~X|H)Ry%d>HQΗ:YxxWXz Ai +dyu>`ޫB˚S8l,-mT%4u-]0Dtc?ׯ&"X(a&齽|T6i 3Fٹ}6Bz=Hd>߹z] IW'$ }$͓ ^ Q\yB $"giK`zWW'st#JPfˉ gh)XЩvJ4*7(6E b29|^&H$MLf" !"w`WwfY\M$|; 6pg{g8qlөNj:eZ&y^:Yqe%BM6yRz0H[1FD~N[a k!asAjX㵻p[+N+w~-WLd0m3Dg)$. k$ǁrPtSOGnïˆ2D)[26A59EujHn]M,.Ɩ"tnnHL`(eҒZEv3%SZR*Ygq|i0lV+4 T?Ͻ!C~] 똄.n/O r+kӐMWw+jjT8&q=/i6uMWvww(>j!8" }3 &"y-;Vej׊dG)cU]tS_%%e: >=Y|~&gӵI$E$%Dޠܫ^~LU+u" ٦X8_Ŷ?zͲ'IjW8TSdOelHHKyͫsIPc E K.[j垀$}#Nj2:VBMwt@E۪d I",t!?|mߍWn ڭ߭E({`WA2X&V>΃<L% &OE6"e>9soe<ζ[|/Vp,w4X%{d438IL/Z}28/;Xyv0Y Hp@ũm3"4Nc+{]ve8&|<~#Jf ,X[5I *`  2T&‹ϟgUs6? !I1lVڵVͽX?*J<;$NCE _H5LByBZ)9ҜeKKunr*)# 'P(b5)*Vcs8qveX`d5ORSl眽z #OVaB Rj,3i_9Ȑc86O>E^R{ if+Nώ>U[V-{O5|`[|X-W^,ٳg/Y"!f YiMN{_IJµsǏ߻5b8ߵ͗7?T$rE+̭:`)w/F뭪{6_Q5V~,5^H qZߪe Jl"xt:2WCD'_s0\B=\(^~oPɵe1\ Li@ "مEB%P2V4}zi`ڨkڨ*5֝^PQ Sb&]J" \ǽ=>_~f}&o??sx2Tr^y_;O\ibFɎTdo6 pPbgӞf4۷yŪDNo}zbdkTj\N{ gncQղt:((cժ 0:/84[ur2Ur@rm9;I_^l`^7~ps8ѯwV˸/ȷoF) 4ƋPdY$k+c?K,=* ~]Z`sV.(2 EDm`hh/[OVX!(PQ;wn~=&m^" UHOx*E(K!Jep^dߴo inʁO>.%Xx+׷ Ro0J:Lvww_xA{{{Je\Kx1ލp/Βx~6FDik܋ZOF/T`+d&2яrW/[o΃2*T1$ˀYY-ar@@V*/RVS9 AVAf!LrwE.J3(7*@ӺɓB҅TSQL L~ |{Q[uZͷ^{-3Doe{ V3_]WzQh3Q.CYs]e.b5J9d""z<v hج7cKzF˰reH Һ6ONƷDk;DSvnAd,B8 `f!IYο=PJ hiVNdRATM/LhŃw%N,,a!E*wkwwj||6cu$|U$- fH$ "'yZfTqY u+R|Qx?~rjJl!}A|c7euu4ܬ]d7 ftZȤxT*NNz=亮چ B$QhXl1K|pkweV []{_>F%ljIނŅ5P) z|~<_μ01 m/FYEJ Nqeibũq&k4dȑGilp^.4 4Qg4kqZ08T\ID@ -@]5f^4",k7"~Au9R ;| ΒTn5sQqCiUϣ"\eauK(!N\؃87G_QHŁԌj,4*;Y[I2 DJM-v>`0q{Z-՚aeGO׶gij랝l{"۲fyն_+l(wUB0Ӧ]c{yNB$Yp1GOYyƍ.GP/[v+r|j50bEee@T8e,ë{W`-4Nj8UT_<.7sI9PHBJeWvôZae)}ߺnadؿ}v^r3f! 1Jf}AU(VXƕϤBHl%>Yx~1w`\>xxXroJ.*<Óu. =K-E%TK/iI RV F4*P)f$M^rJc4/O$>x1pt/*B%Жm.+(2:غ_>G^dc;isVvH67܏Y=MONv,e`P*9R!l;>Y,oLfN:Uנf嫢4VJ49/~@Zcqz3L[)w N?z4? /x:; QjӇ$2xFdcXhZb]0øxxg͸KIJҭi& 7G+\E4joA @^؝rdo\)6++omuxq֨[v5 p*!MEձ MVQT2MSaVjiԶE`u!J RO!ZA=8ǯ^)jep6붛Ԉ41 +SAB´l|M"bU?iGz2|əfԫMnǠ6o>: Bѵd<2MR*caZZZ}%gksULOݝZbfñǯ:2p,# tL^oRF鈾>E@[ yT6J1Zt]]3 |DMd}#Dkn"9$' م.&խ9MMf~Y<۶$n5[J 41ئ'-,ˋ I iBT Zi&i*l=Xd QMUɅҌGEMRʼd1")}pU՘̦7aJ879v}';W-ì {p4O(/ / _A HoXV CTT~4[. /A& J:ѻ:`a(lj6i*D\t:?{E}:T*R$'+"X.~͹ޭ7 coooZqޕzMrejHxK#*M<Ўeνj6nSAQ"J6-o7Nž٭TlcGEXE+?^$ Yudbip*XsM?L(MRB@ۍŁ Yьd0088hZjuVGżV61$H0OlH+w%@m78fm~pS@@ 2CF܅Bf!;ǃ;걄\ (ERK,K)N@L_qS!Z''@~g^#HD00$ߨ\.W9szzh4.VIlE A.0b.b)@F=H`F888x 8LFqlQFm2T-i /|ْXFprks9ߡNK(& ӬzYGcmS<&eD-hT:!Q'((jnܹz>cnwr+[mGk:D 49PrtTS:Bfe4Z^җ.r(Xz59["/Nsqzǻk;xI8sĬOE$Q7?XH)PN kmD-""j93'픟\0U,Im^kwk7BP`soѿzl.x ,1$ 5V V))'8w8؝F 0ԏh WOPR ʥdl~UlfM6UmV7MjU*6FOwNAbV%$H$$0IpdL%Qlpa'Ilq1XꓣJ72_7l>r+%DW>;ac_x<{Gǵj%|a;i&cD 1^z<ң6M+.!Q+: h5]t{O?~ɓv+^6kԠr1:Nxu.xUת;w"XFG* w˽'K<֦aeSNQR2Ү\e62o_y+M!\mv=yv~|t!yQx5Z/,Ցנ)9%*Mյ;d1^z[aU:4*#)-ӟ߅܄CMITB=܂EE6V6dr jPjiJ4ө5, _w^/Ŋw[n\.N' v9M!78$IRsf1:L@H:4-r6ɦ5\9j)o/Z-GF׾uJ 亯޿X ZkOzfެWF`h6/6pga 姲cy%tey4hQWZ0ρ@ݨQ-[!Zq`$ݖ{ol A:2K02+TRѴ% b!T߼{Pb(xQB) Ni>HǜEՊN'ݹ*_E$@lԤ?xF1CC@FϞsי;[WLd%挗lH" Trm֡D"$E Gͯ@.J䊎PiKUyBm!c".àRON$`0*h|]suJ*CݑX.$U$]捌c998 z:HN[/ Nv2C@"L2Mo^k܇ә(̓ij\̹+]H;+%pJ~CHIR\k٭9R 5n 4S7ui%$&@VA$I~] DE1m4aμMO A*`ԑ&?,N`u>[}vej4}ׯOGVV/N;%q%yD-|JdȤ닜0P5噏Ca@91 v]ZIF͔d-a(eάL^Gqun]=bJݪSs-j$:%:,IJ+ZD|v j4-,h`WE*HMo8_fYtJ pz{^2Rx(9W|*)k IDFm1"0+R6 GFn&7u NLf؆&QpJiqdj"R?C}:6/pl㣟͍7? h4jZϟ?Vfs2|E:tuDהIB$$I[)3MoݰLk0xɵUf{Il&i-Gޛ[r%aUuэ` .I4tPd9BR8lVvmɔ Eh5IJht~߻[U?dFdbyKUnZQO(&).BG~ɧ%S5L&)hGg-Q T7gkڡ۞pavn8* GG 3?=l5? wB.yWcDI R_ȡ"`EHQK^y޽{z^ya&{xG*pg>}nBxK7f v@+:6ouθ'z",Vo^_xOPݵGn)LIsH W}}kJ1GvL&!_Ø(czV& ^؞_W>&د-O0f/؉=DE@J\{Gn8Y. T){6(}lҺ!(;c`+W~\\5{ZGlS1׸R.7u͑NTw~qqitΝn\HDL6?=h^Ta$0|0 W`npY͌&F位l._X f:M*Y+!QTpenl? YWWV;h$x/n4{a=4 RRye{a,M/։0P؊(2,HTdw{.#~BC|ҥK.{vvva _}_|qggj/'$_\u;z.'f|3H+: %!- 6V (Ns$IX)>`qF{/6pR5( ]qkljvbIC{<;/o]sg= /qCj㥹A8l[A෺le _s0[ !,! :)QNN jv+Y;=G A0! tyb' “*g(N.-X!a[q x{]"u 8' 8("m gPS6G\k jC4b6w…^|qwf(ʥrrzf¹f>"K(~6l:H~֗h`M\HwR0L':0Lsw3KDclىMkB6)t̒Au9(R>ȱ'܉\[>uvZZZ\,K@ F z~Hq(嘇[IYjBD9WS}~X _z/q0n(LpEB_;QXΜTC'Stur@ lNmUJ1+Qݐ񺈌%t{#"cBr_3>ڜ2aɩ AQ.;JП (OM~`0U*泸PCO@Q\jҔ$=T u+iL)`.Ǎh1? @H6BHz?(y~Rf?Z}: Lq:k]dT9DIe%8U3J%NuU !u3\X,eY6B r|`azfD9" !ϗP뭣{+w7SDž|n{ZGְIv.5)j~7b?(䲐t;;|n;f2A&a&nwű?G}%12.YY.]y&ͣK+<*F0,dc)F}[w׎;Ȧl.%Vgئ6י<ݚԠ' }^nbz3O$clqeŸ[%(8\DQy^691ꍽͣs:49E9a'h(]zd$3q¬;ߕ(l%BW:*\;߽K{MdgOs[ɩR;leBb"г@o~s(@c0^FÉ*0bj" r&Oqfq]fE j?ԣw6lX U Ky- U6WmM>-DjJ t!2~HtAvj~.Mμ~G*_VVNw)d/<:[{3w>, :w.?y2ABZxi|֯e{n g `cZw){n(E%+qBw?QkwWgA-E )X]v#&*eJ5D~y A ZZQ!i̢{;=_4FF3RF"ޢp+Ě"$R-*j3Y% 4w R#N96K@GT!n~;D|g=o+[KSL4DĘZSWG5JL3<ӏ9GȿbD?|Ƀfeh喠-4 'D%"msCB1IsO,/"F;䲙[{\& ˜n;)>(ocs.Z64raE DR26f{~JN@G#}9)p CH,Bj7E2iu$^jE[1rwx5svVP ?ب=}jjn5:˕EqG |.! dv\N J1LyU<K%SQ[M0 \H|s_F'l֪d4IZ 99[4B@k8QE?nՓU"yR=q40乹!!:s)S*qs@bYqӡUᣜT$">DjG^<f VHkjrI|:q &ZX|WSq\i$k/&DB Divvv8yMs`tf'3XGEA8;i#[&)ȑx;q3^]{R&Snޣ\#baF9?=JRݮכ+++3sqvUs"L}(̀h&Pī.qGsv?^E6?|RڝBi J3hnopq<vT N^JDHVf94ӥz2NDbs[bAma=60u~bFFS)gf5WMƎ@&@c)es^'|*ͳjUiK7,er5`#ZG2v%{&JfQ6 !5`KqW =oI&qĨxJǐcA.M$Lpr}\9ͼ~}dXVw3g^^33=j m(I- (6wAYlW(C*W6 =s-0Q\J\e贳OT 8]n:!N:la18lxRI)l^H؄yA (U:m$`l$ 6hF^*vgH ƅI (jW3/n` >$cP8G.]`XWZ~ {RNBP N~\ا0Z s+3NQ7Er[?E!`ЊL ڞ)ht+;D ɉm@NuD19H)QC8*9 ~LƴSw**,hξHLrv҇{H-U!e:DN2E 4t5kD$ϡJ;AN˨ϸvӘҕ5rkyjjlK q1PWk!op'c6'OLMh~Qx5ïT7V Lc?Iaq@RzTßLC*2n7"^#cSj@ BFtP ʷڱcMz1h/S::J,dd9Us3-CJbH*W׹H1.@1Qh`G)?r&0_ݪn&d \dkJ6CWJ 7k_Z 5 E<*i4I, ${Tq`W0,'6MNt%3]bpѽyE1#z=ӂMVc'ait٢&gD(qC ^R&0<"]0jY ̶W=@G5=(tF+_ ϵ!JFHD? Be5l |@IR!@O/w/>FDv[lb*lz7 'DK@̫?N&*ճ!ѮP4SIStlXS$'/ ṌrXfJ9yCD̓@h(E]ڡhP?'rfX;SwЬJX mh,d&66.2ǜ^qZ\+ q&ARjFv[ո@".sEps;qpQ~i%(UQbq7LVg8{pش,zgM236;w.3#>1l|ēsoo: l'!LwaxH_?.gL7(6 l@T>-BSj ݠhd\mpWM= ?VНTALZ#= 3 q0ʒN&,kF-f=A4{lrW;P㭣F!@ Ul|c%ʣ-ΐ1!).iIq@l4N,ZxIjqĺlef}2JG#A(,Wi0%UVw`NWVTw `J#OGĖ10z~o`HƯJmɐH22C1IhUITGvd.mC{$K 8%L19&C%Q"}֌<(Dw~K@"S"CɒWxZ!D0*M62:%hdm5*Vb}$feyUKLd̺&ўr9زHR4f#ZG$K;s((Lc}@1/.6kF1ak0nL*+"sHRg1đ.ZX )}U]JQ5"1RIN}ZcheU^WJ0$aB6n, ?`YR iO%{Bq0Q.ASb^=FevD˟nDSy5 35wj!J>i0#mTp}I(Q$t@xwK,vT 3c#AK Ǟ7'GT[KNrAD۟cWЉp1pY[MPtMzADBa-dIfv+ ͙B#T H<^Z4C0Li+;Ċ,oV FHtQ 2@xe>yJeKa`iRDz\]]#L&f3 t@JĹ FgXN$c PNoxic a:I_ ?Y8'g'xh=ac S8X .3Ċg1d2t ⶐSzӒ:"I(BR1D!SVQ{I>*3G cbWE K3uC@RZ*e=j#"ElUx;6-Қj.ЭY@d+]-~ŶVD)!]׸Zgo#ռ{ Lh? C#,M@ЕhUM9p> X -$GLH-Q@YUKe8#G!T*Lrn .k~Fi-31N,ޠ鷛懃n8A&p Bus3d;ލ+o/<{s21qݜ]\IoתӉjb[tK;Xc1F|2+D ЀC;afHDA|G D}_6WsmX 9%8̓.ۋڒG PtnL:K`_cL6gMdr沪'ΉCa&b*qb`d}ZSSTBKNP"`^B&Xӏ;sȻi'!Jy*ٚ=<^<ϋPT4ӇoOÉUjB1vr_.v;Cֵ\xև+es4U[UC6A{z>_"- a4sVemsڹT acɸ,dLNعk ƫtݤ~YN_{duacC5*e2~0Zy7q3X8$O`z"1;.䞌 1D97/t</GUF M¸azg&Kt *Ӌ1[P*dq~&Ug\cY%O!b촚S9fW`9{H!f'˜/h |W^=|"tFve}rb8ygoSWo,?qhNXlת/$.\ߺ;^'tGɚ0Ok5zǞ07m1yڇ*7Ej%Y "fY-),,I \)Hjٌ ojZGn]f^5k7d3&I8g9`d^y2 rP9 qV!İe몬UbݿO|{幥ӭ҉3{[{[bygsj֏Nֵ޻ǟik8n'\wRur( ^8 Vx[gzwQLKnGQujNL4v1 a8d(=K3DD1629#+aM B߆4ZY(!o9;s|.Ns?d?^;Kwk޵/x|SR'/V'̓`0tn6Gd3p{kýl6??;ѕ凞Jo~&%{`榸g'2cajEޓ@c+?2O!V4N'Gl3-b(b։j-fja xqhs[${D  8cf }k|qq+[wLJ7;3W?^]\=r%cDdsv3(ZT9ۺ{~m5o^}7_(ysĹ˯~wԋ~( nvv}M:f{o|gnEp֦f=v߆hC Q+㠍Щ!Ny7nX8?vܲ׫? #oIJݣr\^LLH~N{jvaeifda*7g|~xvy 03N?vP=RILf=0`@)"-| !Dy8nۤyG@n^SCJ]0]#\RY~ i!FE%dR9 MՌІJHEц).IҨƈ;&uTgV{NmcS~Dn`Z6&C|WJ|Vl$I#RqJ.sȤQ[Rw'zE)WJL%z(q1G)Wj8?dbDQT{zt] b9CGtV9cCAo+-M MLC=u6&s L #cCKGM5r{ORib##27咣8lq#>Ғ#%LSĢg8cGđ8ydǢ`(GSر:9OLq󎠙NXGAI Qz8JQS7(KH+\1&Yr\w SI]h9{SSF$7GM]#[{z:Ӌ_~բG&=]!eO}m=7]<"DCe;Sv&&YcejYdgY5v9nh-|y%?1=T%d!!*Z 8ڭ,"L0_rYcwx,Le:_'8DqL 7a|gjIrY"ysDQ,QNSBiJ0E&(|@"="GjEP8t^yY7$\0P(Nn.Ng j)`ǿGz"V7\*_xzrQ-DQ FT/0 `iJ ^% 6s1U 6<M*NkZJg_v7Zgw%g L~m8Nznlھ xB{488z$S|T#rH`dHܶPh)5hb84KDl돟)Ld/}XۇvCΞXï]E1e|~3g .ÿwk?y}>y/?zws~'W]'~Ců[ʏW7zxy6W-o\wgt@;S~VG[wG~KNW3m~3_d{lJxcf](i[5d{_Z(gU?SvGS+??ʽF;a}omOU2onNv7zGO߾Ѹk~틟yzݛ YY%r!;>,ogk[ݫwZ{ǃO];cW,vf'_<k$"׽GO }̅Yhv{~|.}Xb/ "YSKv z{"&J ,]O Bgۑ$B5V/@:at??6.ѿ0ssl[)gֶ:o_o矞>\ǫo^> &A·ݵGO?y ?{^FޭaX{q`Nows ׎?瞞nuKs_X|[;A&p?1 juï|{ԉJkv'<69^䅘jiBԺ=-x3*(_ueD8l _~{'UFi_L# [?K27g 4/-~k~ձ^FG>LO V8Yd%SkB LEqlb9sBez Y(dN>/ {;7\q.p].ޯ_>xF'fr@[%LB%)KOM^Q*q+hiH0@r!hv"NUg.煥$|fIIڟ'[bvDYt[r*klkF0Jg+r+5߃avrџ( pm+?\J5 /{~_o7-G>n$Ҹq.ݺf͝]bwv4г3㿸7W֚fJ85#׶e&pqbn,BWR3%Ks3_{&=|~-V7yB71]>~ٿOמt⃵œ%0v/zl065ᾇżک_xfj1aW77; Sϔo^\d9Gr!(}o~VoVa9D^M$׾o7~#J߻# -Q W ˮDtOw"SO 6lHo`%F{{W77_`Ib^Սgs d9{ԟ"Ѡ_G'秲Atf8 F'f`_o ٌ~<3I?V 9bvӹZO/9>?])4;L5;GJf6hwDnmv=Jy~*vz'v8k|> rs_βI؊ImCʸ RCF8s+Lэm:Hꢧcg[g$t8'5iʠ :ΐHFa]aFL4b>|a *,>c?2/:c#oFB@uMЪhǢp8`UtYr-}P8fCfHhZIfx EZ$œaJR>iȸl9뻭SbWK/=y˗??W}߿kғo}_KK O1м;Q`%[rjo(NXTU`KNbĩs;K$a:A; =؅?7a"kpzFok}[vz][}{k0_yV_}J7>zwQtHىH <T[uAQ:\<)n]ەCWK˞@!ctEnttFu;@54OQln.#6qCܛYrbU_====7 dHkx^o؎B6jA@ `f0gLwO_wᆱ*#_e}U݄Q1*2+ھZ` 6Ә;~f6 Zff \[;Dg4ebU1"!٤XYx4M~G`8yRA2N(jycYdPBcg`-Pv`.A?TbǬ8 X +S=N05?Y9ݰ@0AqJB8 Wd hh( pH!;̎~ZA/aڡL-e91MP&mAsEV Ǡ1@$&Hc`Ҁb-=۷ 1H~`s} +mX &%Ff, 2 lz)9LFNkPdXlxCDQ{Ù3*B#c'MJóg!Hu]BNt]C]1iBa4׃Bnͯ1uX!4-(@*d#a8Ц^;S+v+^)Vơ ) 00~&Lh )l(L`8j+f‡Y>c&$zlۇIo0s8i fjۏ"6FZ~$A!>,4VB %XD [_oԕ~BHT۸pa$'h42Bϯ&鑑@t:"NCc>x,X"A͚М0! q#Q,9Y Z +ڀ!r@kkP3iDۭ(`,LDF%9 X1 L : 1"Ҹ'$XS"6'@*L J<nj` nqN(IexA.x Tp&4hrvs  ιQء 5z Ylzb~(0uʤX~1K08>/Ao n*w3h enr&p F# ɕ &.,#D 1Α|]A&_H\"ZXaXA<L`갰c*n H[b 9|k-UBFm/@OB4(D`fDAi #ءN*:(pyɔ:43ŴYeX1(6!iJ%M& 'o/ܺL$鄠_r޽B0aLE Dob4k*"HSNؠN[М`0M{0 m ,,)abPIX4S Д#26Saڷ懞 L d (X>Lbz NM2 \d8(03HZĈdM $&@枡1w  M_1sga` H$$asGV"J\uf2FEQ_4lRZ:8&ѴIKǀ2;P`ˬbgqڼS @$8x%25AO0#25;:=S ]i]_ .ႁ%`A [л#Ed sO@&:/Yj, Po ,R"io/@"I GV+\4~"B}Mӓ|弢w.v!@|$p4Y  Q@ayS̩; R4HчQ†`H69Q Z Ѐib+Ԉ[kW6b-F^[Ui{SȗE>, [ ӈ0c>Ȃ$aE| M6r;EP O (nuƢ9 #*f}`DfKod``X\  Z H0DC pSt0Xc~ `,kEL5?/h!t(!ů~ݻWNd2h4;:?o~:B\ŎR%wt762!D?}66~υ cۇxc\΍Z( @P5 Z,ICB"CC &/YĸF}"Rr:Ǐ'kkk{Z"j@(Vǟ){eYY]܅B!25544m8!40 `6:1&kjU06嚪A,])ƦLVTuL9x cca]`߭ó i12@<rGʮ opED¥6f-`? /_o0!$᠓pzD!9a s#L_Pt-Q01`XS  t B۔XB`ɚlJ(4^xn2/;Fs 2omc>ޔޚ(fkhdI6=zB$^8G ]`mfO-1&S6yd\`SlL`-q2| ӭs3˅ ,M3Wσerf(L#d+^H9E:>wʿ7w tXs-Z'<>m 8(6V}ֱ)زRE X9ȉj51&,eLD!~= NtqcskgJ5¹pyr/^:>3o N̳pgwvXXjXe;1TN`7P/ff8ֹ pfaj[I[ UAi ;i5 Sz \…a$hЅ>CSeІ,v.&m)06XwAA)2.3x-,\y2/ړ'?Wg3w4Rkg}shTQetH++k!㭗bN^r(\ȧ v1~L }uCP[;]@.07k(%l{ߐ*"\0ա=M\$papHH@@*A (HyL@ 437:y~X0[ 0b4#swǥE+u-P]֛߫3W[|c2֥Xwj'a|lLs#=FufTkgC\S_wa4pq,vcelcex1 PY@ V7`r01o7Љ4nH>t JЀAbN351j㈉ܲѨI&퐒 f&%fiwh?ۻܛl RLW`3y7o(B30? :1|aO"k윂ˤ@|$H +USFB~B6aá* m cMS׈-ȢkTvyUD'<1O),⭚tSFF! 3l"O9iBX\k9dh=}O /(0?@ '$lc81Jx,.AdN]Q0d3M}Ll/(Aar`0O2n FP.L;S}><N۳u JشAm1I0D %,.6>qp#q o7jpDY1,jL /C  O!d330Yxc0 (afPD3f?<K;Ոqm`(41.=&F3m'.6PnjY81c/도j[k,@[^dj'~VZ5szSZ4;kpRRbCfy ~ VrA^ W-B!JĠ6+p  ~ւM̳q ,| & *M”Mㄊ)п-R>50J@gH!qjYpy11,,hM0AM )r5!ĭ,\о0bd4'N&|Fw2 ؖ_)B*dY:B0Y[hbeI" ܜ$]%_a)I5IsŠzAM6Fn˔V%V`!hjn 665ẁI%dעMBRaXIUϞ%ALP>DmljT*N+z*M~A!Tֿ2GGJ*ʇrz|\o BUKXM\&$ 1jcs d(#"IBXJN܄7\ WkeY ̦+等 YQ'7|\& ALxn䴦T !6=#ʎYcB5'SP 9¶JFMñŭ3F޽%qPܚ)+ j1==Nݧ##===QY{{;TUx\rb!YUUsJ[-|gѳ!fdLTs`.`̐(Ь` p+@2;\ccd(|b&N2\fA=P&aBG^L#g?ly Xd >6QH4¥2Q#h_$yX@llwbg'Y5UUusR sttuEBo^cc} cϗBP{L@d쬖E2S4 1A+Anmtb oV"U0Ju籰Vxem%,p M3X@f\ mc4S>`$%ً=3x/dYʄ>a\1l8*T<37cbDD-lp*bM8i`F!ПICd`l`d# 2s c'Fdۈ a8\cU% }L @ٍp؃0m t~@fÜa 3 * q lM̯ .X;0X1$b1~d ?] G`4Gp@8A3Y" 4 2L0PBrIހ 0\ ʲbXvC8u$4$ M pH'p"2ԟK]-fR3Ygs9E2Ox`Ҿ~Rtkj Η[%؟ Ed Gv/`&6 A?,yg!osHi=f jԄ\@*AG?*Š Aʗ[}gsy$Q)9H[Vfh`nTojݞLFIH}㹎avy}:Q-oW f^ojŊP"h7Y6w~yˑ'4PB0̀eȱTp2US,=a4(;/ߟ7zj j?{rw^k#iF[=~<; FZީ`U t 'y ?`W !f@+г@X ]'UGa\ #!F[ϽBدKΰczmD]O7ˊ,$2AІꕚ`rH*uKUr3Iouoo׸? jD0Sylǟ%5Mx~`!t)hlG{F>eq/K:ʕZf_ !Tu DXQKU0Fa~U0Vd\i hpu&#7SծϞigTy\ly\R0&"#Xqdl6ilVXn$~~hBVOF{0#\`$v+ UM'rMB@gƭUm\^\QYr٩/) En4_7FFԍa"Io/&V;;lmf!H: "BU!k"6SB|!OTl, Ւ3Lgg'!diiixxV[)zcccllP(B-әGGGΞ=vX*r8~ٳP!4\Hؘc{[nZ(А"I& GGZw\}q.---OS{{]GD)H0(﫭F}54R0(mnT*NUUKٳg܄'`!C՚bhPi|L*^0T(4vwwϞ=+Բ-F!$II kV~?!$Ra؟s(!=5p@lr4 04!>~0dJR ===W\ⶋ`9qήUd:> u!ۛ<@';dX%̝lEt:(PgϞB1/^GGGH$nll$F +J>r.;nmm yΜ9S.;;;?~<55Ev3BlNMM=|PUUF JP*noVFf~xe2ÁQ^'2q88=Id-²t4doOdRQMRd2z.r"tvvyn+Iኢ(;;;r`rrrD"Q#H\.Jltp8<00N%FE;w`ww7H|p8L}ն>V bXX,VV:!tr9EQ!FcttҼ?88j<F%h;嚎33F9wl ,oVXd>l"yI5-ce||< aϜ9($I===~t]w8OMO;vw^%Nt"Y^t| *i$d{<j)K\;;^XiP`PJ8U~ !k _W7Nfg+FZƜNBJB|x(`&&&Q(Frr<υHK,Jl}fCa&ʍM0mOdFfF©nZ=zV_|߫\jXP򯷯PEGtJFQV#'li/+#SO61{-3fɶ'fѕ?d Ykx"N$>-2!KuF/hGݗdi |gMSᬌdPQ&[ !H Azl,pw%;xk[QTH|`ڢ>}8Uz*UqVA eÑZ _FA}4qa@CFL@X[D].7kV";TPg^(4TU}wWWW1hͮ?S~ t4??rn߾ B7o\]]u\}JzwܩVO>CG ʲ1,wi4 lo!bTmg 0bbepnnBF/:UM ] N`UXT֍RIBv#VVVK4Hd@5NB^0B. )e zŅ̧y0 6ni>A=f؀`BsB B#ӟ~488hh[z4___ۣ$˗/{]]]}}}+++$ ~SSStocc!Y'&&^fflvhh?ַu޽ahw-.V] : 62r8ILNz hoydĝNfgJ*rPHpN2Ázzzz}{ϟSUR,..6 ñ6==]* /@4_timm-HF"ZF7^o8~E"p8|Eg27|g?t6Z-AzYUU1Ɓ@@W^y%['t ۓBg622R*WWW_{~wO?a}]wppp07633sx<DRǏ{{{ekBGqR懖>2!2We~2_|83n? !3L4} ƸRZ-o|d{޹F}^;/>}͛t\.B~t:]T4M[__7R >t~A rIѨ2>n6Ȉ;VWVGG͎O*aOi J7n^IQp-,TQtJZ">|'$yx𠣣X,\`0믧RW_}uppT*&x<~Y *ЍDPi;!4==zkZWWM&PӧOkםNٳg=C!twwe(ofXbGGGi!ٳٳgKbvOMצں?d2' 02X6Ԣ#>rhzwX]]|7R) ʲ2erZV.V###|v7VDrԔRZ-EQdYVp8E"lYt< /<|XP>yRE2$ZՃA^uݘV* .ԥF(t?'BAsz]w$BHA^ĪJMi$TZ-?.] ΩJF4ucv1ƺTD^n> `MT,i LTnj!ƣdF/Wh4JҺ\.EQ^>,4pi-ׄp/Ll5R ,S fYTx<\,7 ǃH| WEzzG*pXuUU%Ir\JQ-Baws#C{1Sq",½dQX±A_'qn)XB ^o-fH4xa"6gXܳ%|̴vQHA˥\^*ǡ>[<>>>D"|> -,,?l fgg3L(J&X  NMM6Mt: BOOO:<ϥKIBVӗa%c1IQ I:ˆMC4AI2*Y_ojl`bN;:;[[[ކBhg=8X[]JZ랞fnJxSPHUr/ issKi*b>}zViMO@ŋ-TthabUIoś\,E)JxQUUUUϷtzT*gccc>OeJ l14ob)(UDcd'1s21!vvѣŁqG"><<, t TUBꫯ;\.ɓ|;kooJ4~iLRtuu333r9]tJbr&wu>r@@*uYF^.LFsەIXN;*)v:BQHB߯Bj__Te!400L&{O>dppP(4t:H$www/^ά@3MSXv_ӧb[.|LWWBc} @ƙp8Y__ؐ$BJ\. 6\YY!$IE9>>P.z02>{EÄl6KK$tehh^jNu'FuF)G/oi% yBzib;l,-Za1f^*`0AJ𰷷 SL&C5$@[#j&*@cժh/{m;1Q%Ö=W8 (P'qAZu:ќ"tv2C:99)$SN S)7HY`˹N2ogg-~xeb+42C%0Ge0MhEDPC!B~J-r I:aq;O\c+,!vG(T$_߄F`7y? 1ZVe> @dc)"$mob]E"01^;:0p㉠cT*;ܤ\.CbjTUϋ rp(L6Ri|ZU*55m5::jXZʑ;zDau;;j۟ T*ӡAPPVaJ8$zBS ;; +Kt[bli+v775H9N 0uEe&N\fu#h]ZZRzQ,t^_ =|PӴw}^R@ ;οzG}f?DǏ?{,L>z(Ly!DOJD QioXkzH2{gP muxwud<^±Ō,䙮bocᇛ_O&+NBL޼9{޽fIܹsgyy?|2Bh+J~{{{{ggÇx LV*G}l6Ǎ7?~h4o6 6H$GAj5E̬ ߸qV{9L&#IO~]{zz~ӟnll\.??rյT,Z6ݣ BzY[nፍt:}= ZJzs3]ܹ3>>~mBiQk׮hV[NgvhbXT*o'|255E߭өNy:eYju` Gn޼[^^Otk{{7ϙ~_looj.~ibbbyyymmMUt:x^z饷~{R|>_y񾾾D"ۻi$!7g[VߟK$έV._Lx;*;sS\nhhΝ;VҥKj7HVUzt^`ӧX,vƍd2K/ݹsgggܹs xc<33CyA2xq۴rtB9aQg>pqdό"F!c3Pt1(bP ###>obb"|;ߡeEQ% z^I=zD$FH$rk~񩩩z^V{5!*Zl6_~xx/SIX,==By<@MaAᐇC^W{{nrx؞ls` o4FC|Wu24TZjZV[t޸1x=z499D˗'&&dYNR###gΜ ?zzzn?X*5E9>>BNSP(=zixp0Hzz޺uܹsd2ぁp8rJOOtttszII$2zWPh#px|~>BGr?X*QQzXܓ$Bxkڍ7.^/41(dV.'!TٹiyDAǀ,c$n 6RMb$.ܷ{P-eSNf5mUvx"uj93khj5o BMpM4(gl)IZPPfl~z^vC-X5B,舩ڟ8b](UU'PA&+ sҞ3e\. fx~n"qg 3x"'{8n?m6ߪyL!^oVs|Baff& ޺uhϥUIn߾MN:v8KKKM󁁁E׻_[[d2D"A_I&Tjsssgg~w}yi z].RI X3g:<>v8z.TRINN;j\,r:Bh~(գQ!Q1?l,'ObQǵwWVVjZ.K$drooommmttc\,:}ɓ't8~(޹sp8}>B?w:D"qttvk6;w>~8oݿvkI:::ݻWV1ܜO߿Hj܏oTu˵M[[[>`xxxyyYbh4W`E#{fs}}=P7( #P߿G@a2[[[\uM|@ ii`0ph~ 8w_0 BZ^A\Vvw٬PP|>\1FRȻ|^RI>8p9ܹZRLTT*:evgEJN\&N'.3m49ݑrtzff&xޱT*ET,--UL&?~Fwww+KKKr!s~> smllz|| UST*~GGG__~"#zVǷ!Y *r9]i%Bhoo^BTUJP(DY-Z-H z٤_p:R !Dgq?6-KR޼yҹg g9!::z kkkX,LR2 B54D"GGG2\.^wwbJ=ioɕU==[YYh{םwNT4 %Q|n-R^д&*?RVBN*<T>_-'j a'$# 9P*h`2H˿ŲYŏ@c` Qօ :7!4s(=:j"( #sHکG޳ҝ;Vf0L'k.,HU}v\C9?l|^ODG'6ѨdNTRQ0=[d9NòL(HcfqqtaanvAZ`]Asw6t6~.b6QW'!kMӸdeEd!l`4`-F+NA>1*\kqb&P.NE?E) Ҝ#w0$ gC(F&"A(Bܑ`Zٳb)c0iѣGdXբOD7^w||wV*'O8p8|ttTT իX,v/..v,CH$PJa,|q&r^ Bk-&un J&+FsHtPhi4 QJ1VkK1 H:~Cf*r쬶ݻݮ2''ENGJZaa+++O<(y ׯ)ϟ#7ӧOfɫJ (٪lnmm!ǫW޽j?8X, *V$Aab^x9fQBNR@ٳg\nrroV`\Tj5TMV;>>(ZTw{%q~m>G8W#G ʘ替rw||LQԫWJe6=<}*vSN:0py`\BB_nT*6- A0JOKdyBB0:IQ#ɨp'lhL@RzA>Dnw0 ˡPE666vww777.KTz6:ikcc޽{wbbT* _W;;;&)LS:7jɜ9<. [-f&' zY6iD"~x::2 5zj /4:tss/ݻw20r7y/fz*aAj5˲(eُ?lrwxxH4څ m՚Jle硤~d2 Y١Fòa\|1:!hJ%8D"q}}ME1 cW);noP RI(pd䎚LVGL6`܌F.kyyyvvr|g4M QEQw8N<`6|C//--!)EQ<xÇ~H$BPYYYAG EK77J.fӹ\FHZISnl4MkL&gVX25ū=/ӦөhT**<̓^lO~FC۷MRs׍Zѣe2 @ \._>liid2fRkjukk@=}'_,JӴ^gRdޕu)j@bx̹:?l;-J#Kz!v)->W&{+0iEQ?$+Eq)S9<{ewwwrr󽟌ϟCK}ٿ/4_GK/4YG&rH ÓL zmΕe3㩧] L)x|wST[i: $݋8'THx8 N_@IpXt"AV1}#GH)ձߙ$I;y̫ 𚇳 % z QI0wDި`/wiC?!HԤp+;dm i$D$ N}M2Hn3Mi Hg0uGФ;D4hĞ4vH|#JɀҞ q(e ǐd-&? 7Q(p#iHf hp, @(F#1$&@28lW`r3f uH6Akvb2H eN9DHht]\\— N*"[JȁT&P_2Lf~k cR# SrW$'&R 4Mv(ĉn6Gd[}WGrdx%l] w0/3vGlb FIQPrʅBᏏv?}z@ƣia j Q[NݍFӇ1 ȶZnNERy YFӍF+0 ^=;ZX(vsS6|5;;vɫYg^}w7nwNCLpvt_E;w޾FӅB5kX&w:B,Ḏf OM9^>K&s(oh4ժF۷d>_xl4Vk]͆sMh Z^pZMTX)tkc*RjCzBAe2rnL@<5Ѩzi郃d2W(NO/+?.-͔J̛7zhZTF&RDJE<~kbNB!Bn,#'H|wbPAU }%n*P6H%@,jm"uU#g';iHjsZ IӅmo"+ rixE%#>pE~a*"ȹ\V-䤕aZ~d2(2nw *Iw5UMO;YU7u:-Mj5wUJiu:Z:9Н^)l\XV6Yjs ɉ }0VXy޼NNZzmvV+ffV(BAneBR&YZ9=|6lrv;Ͳ-դV+ jm-psSXRqrכ6bvzm6^h4tZܙB06Wfg]f{ii&Vf!,/X\6QBufhp fe[fqbBqJrYN MN 2LSt$ܜGRv:]^{P*jJR RN͛sffh\,j6I[縎N/,Ll(lj4&X(f2;ཅT\OBX@<wUVHa_>2..罷K_\(P:Q=X}TQyԟ!JRIGOqX]h40mDRvy}}Śxdk}}>D&uqu F߿rYk5f3U*cX8|kU*%@Uj,M) +&Anw8h$Z5 C_]~_*\eu՟WN 0@2G:034$0AD4GZ\Bu$M9Z#mOQRAʎiʪc;=Kx/ 1lRV0 #I'qU 'jJьbRu~TJь^eV4nׁJd2qO?]ߏκ4U*2Vܜ7TEBdl6Y;|a77X-4m4M>Z(@Ԅ}>l(`A։9O4Tz]__XXQ#33n-͔Ju$-3L3M3L+|^m4R!t~_2!&JET*S1;xIDF[l+͐pQ V\%G aѵHrmyd'1{;d+RET"$#t S%7)d]NNL{VPO]]u$I޽yY l6y)vyZYBM A\.WA޽@m4+榤өՆJbnw?l\fwvg|>n+*;;;yy* FtҢ>( zT.3\Wlߟrl&בUff&u:M 6Z' wٲNq:-f~rҊ>3r8hĄ>)xif^QUd^g(i:Vr8h1No'E<l@Hi {aD1+HyP> endobj 141 0 obj << /Type /Action /S /URI /URI (http://www.megx.net) >> endobj 142 0 obj << /Type /Annot /Subtype /Link /A 143 0 R /Border [0 0 0] /H /I /Rect [ 413.6467 632.5268 429.9097 642.4474 ] >> endobj 143 0 obj << /Type /Action >> endobj 144 0 obj << /Type /Annot /Subtype /Link /A 145 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 101.4555 260.2500 320.4555 ] >> endobj 145 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/09/soivoseltamivir.png) >> endobj 146 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 292 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 300 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 613>> stream xA 0 =fy9뀟\cz~ endstream endobj 147 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 292 /SMask 146 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 300 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 97415>> stream xi%Q qNnwj_nuK-%dIwlm0ߘlc`00lÀrk_zVo7f{ }Gu8q"Dĉs2FDqM" [&](,1zaW{RH:(م(;vwy'GBvvwo=>9 ]ح(sfv0s9ݘY1lW," 1EP'ѻe'a;BMpN*Sᣨdٱ[:(ںYE-5CJ:%ڡuqMvSN{:EUB DvF !;Q;f4JVu7=UI׎[9=خX;A9zn<ݤvttp="0(⣣t_tJtBu ܨ?bЍnt0m!w=]I:u+gQ](׻M:zzzNX&#+~/x\!箮mV;~ SՆ[3+us"G>'T7 8zE7vsܝ La^R2;x7GzQtNg{г 0)m{W}n\O4L·Wv0m 粣.w:cu m݌D[7L`Oȝx `zqg']?/9Ss~;`ksyݿi:*//|aD^Y_lܕ;k_|㹟h=*cS|>kʧ'o94Cȷ^}y Z6+~跉HH9Oێpici znZ7M)TgW'O ?ouG~_z"}/oeH?c/ {FVrtpq cjmQG=vW(+^)drXKu/ ԫaWa9GqO㞏|x{~o?˦|?{pM~îh3~}?~.@6~v~/>#\zkަe|xW}ӏ/ʿkͧ-&$ǾVkXCoxo_7Ot~/~QW}g.=Pů̀o#y/>C~ow 0:{#[۬~1CNqQGG|{]ZObGgvMA{rѥ!LS}%S8 -'Ηdg)P_}ϛ;O=2iמ9l΋3c M"2-'҉ɷg?x>1m'LvlǕRFP[v` ϧ$|"$t{6wh@]~wc(N?4J9m/tpAR)nBGӳUiG_wu݂ކ}zuhgO%2(˅Ijn ^;,v-:G}JOڰ+~ww{s'N!zYxG _Y>=*n>ܑ#x˯}/,^_;ˋxͭ+륁\|st{x5OU]:ND<{i\vt/ģ/˵\ZHy-?೷g_{✦*c|fvi؀+Kfxx=_x7!ۮ_]*N?37xu5nw޴v~>{봢~~bp|z}wqޭ6ܳ.=]KҶJ[$'wyO9^v"NCaF#Dv-{NK*Ndtw9guNZS]xyIz.2zOCOvuz]bn򁝗 ݨz2u}zfqĀ*b 7OOxWGFz6h? i1zaG)8c38f;$駑h;$24i9 RUN;]Dnws=Fwmf'lhwlݻ I=ۓ]IJpk~wq;ARO9$q+=xMD|d+.xS/^](dz\"n|ӳ半>;Si 糋V_Y(' ·ʵSnj ]797_oZ?uWWpv.\۬4~8מy~OiXم⑩-]F?Ģ8}_yǦ|ov\%!.{:(1 =ͻ\DưϨ(`R=[DmeQ =G{UtnnʣSݚm;7\,_^X_]ʷ\Y*~ԹǞ F?6O/:ԹÅ~Kz>e3ֿcOԭ.\3VyRT[Xʩe>g곏=L2w_x|r01\Kō{~f o}!7U,վ.-gF{ő/>v1NĢS:S7.}:vK-vb~OQEPn {vGv=NSw{]dmw7ݰoētӁ1WޑG,mg hh԰42{nWʟ8\W{bzMr801K'r CD\v_6y=#D3$?wvg.gb ߜ3Můle_y|_\X٨;n8z`'C:;=^MwǗl+&:w~v߂d @3&|Iz]`H{.QJm^xN:Hpw;n_;u܅(d7pBtz [=Ӏ[E$cwRwd'^Gu>%.4q^/lIvvv7j)׮䓟mtϧ&DnF^iwK#y蝎 nvׯwD #lىbv:Et?6\^&fw:쀳Si:=cJ*T\&),ȶiy. 8807.j++x*8-.P,͑`DQ84Mz/'ؘɹl6\4T50 b~3T\8@5^DgWp1r_D;w#Da 7WBz$knƴJJ\sqD_Z;2MjHC^.W̙1 X\wʃqU %B̕-o OйmĽD\* NrciӬnvx,T17Nda\Xs;})A2u<)UƄ$tdJS @)Z}ߓ! WJ~yt  דo86הv/+T|rdxn+J2}h@;la()A"! H$4m3Tޥ3\HZWjYC '7~jb͹P:|*vp8yd!6<džc ~_V. a Q34ED"[ep-oyG7 _g{|CCCpڵ Dxhոw^vmrrr~~~bb J%5 EQReee%裏fyZ-ۖ?ocLU^ukvv`0u==i}߽cax܄}jU<_7׈j̑P|­CczNT8n6-C(r KiIdɎe)'5zt1D<8KL;9CPΐ <:Ojp1HRE T+sT/ q$uZDq0ypu ǣ-1t<" L l$7?ת/Η ,)7h{(K-Hr- mqlݸ7[iY(rƲGV.οBe+h7V hN=Ӄ_=Rٸ\i8s4GĦjȵQ,*M'ӢG2{'{¡B9kkkgΜRΦRC?bxbwsN D|ǯ^SOu]_ߟ,?sw|w.wϗ.]) Rijjjss3 !N81==tR XuJk o?g>j\zLQ'._ʩT 3 p誹R3 kUǜH\\^pw^+ 4] 9)Ε59GCQ|($5]4USO$'6,O*CBΰ/a0$MZ4Oj$9')R:|Zt-GT ԾM8_Ⱅc{כYtMQg:iǦH: nWV`<-۶ox:d` ,XEZ$ԁD"pѣ ٮL$0!= D嬐J5Sh&0ܳ3d0wfo0W"uTDYN<977799:S*cD"Lٶ=99Oi}}}[[[bÄZ%J$zkR7qD4Ms|||ffرcQȞ_zucc#۷G) ew}.\a .o+{=ܓ=Z.٬(7t??22+qTUuiii``S;T*y^6f遴$3t`b:>>I "'g|Z}t>#'snަ2-fbd:pdL#2`ܪ9^T}I6l/eh"" 2WT]b±] s+Œf?ފ=&QɴZ>2)$5ŭv9Kܶ/2=,IM-/,U]Rh2c,S8ͺ}Z98҉;~n8y2s#{ '|W|744TחGGG\r=|jr5&*c3kLBu2Xnͧ#IMC "Y(O1@MKꊡGMS_4kD'{7^\]]ǗJR^ؗtU}#gݺ`Zؐ_.OOb/٥ rtLWfʷc=tcCoHt맷ٌO 焂ō8Qɴ1l6tDRS豙bqIUH)MGa|0Iٞd\OrT8"zRjK׶*cik%EbnzmI 0)a(k{hyjfpf~f~sW49D*BTY36[(R<11_l 37Mf58,,R*X$(FC25"g]Յ&7fDZ߶'H:d 4KM'УE]BH(ۉ&-=yŔNZ pC/Z芜9|f ҖJ=dtݘl^Ww" @@vf/>KʷNotQs疪Rk[֍S+Wr+ GsCcZ˩3T/쭡بUʸ!*)IiW,J~x$ӔlR4@Ι ΄"c#$QJ\EX0!fb鈺5,P+V(+O% ê" gUSxfMglCdK[\Gq5MD Z4N]ܨ: [P*@I 2͚ng 138FٌlDq4M $덍K0!!CV+N2zRJ2T+m44Tnyrj KJ"0"Zy+( y I_jtPQd%IDD2nֵ%ϗn"[v{PM8jv,3ETJ zAtvÜ#u (Q٪;$rKOr ۗш!ޛ=S7@WkneS9y9xDtlpbUĴ~c`(>8yM7 q#GȥĭqtēRa{'JD*i-m6if C!gl!51FI]%2|JOou5)7f )#`@:mh*lnMh.(mgHA!RuP_S kH$Lו?Oo#($tU$?@eiMjk'Ur ӾzH ?׿*ŢiB! І:]StBS҆z۾t]O Gd(\Fv-}w"R@2'g` }gS0"6zT&DH յzs(ߖ1q{RJ"_ghhzO u%\oz˜'thl6%f' BJkMWSECeKHG'7B@Bjndօ I# g9 <+Fɷ\*uEȯWg(郞ڶ8D?m?mALcqVk;n-$8R2DW ;yyCEVpY@y(گcckwRPtt1D3>Qnx.u"DEY/$1@I 0逨+[a{j/>p$LJͤ\êL4 A˕/r'MLĄ/69" gLJr )U8‘!ZB#2d (kh#21M k ScYձ6jkcjѓsM;:Y-Y)5+xv"4s)4M;Ј7'!p&I<'J mXXX~[qXT+}}WHݾZYl?> Moz}&H0d4όJ)OL =i!6mϯi{$֪VRS_dؓZ =o/|<|r*qPy6hmm$AR 2 \L )붫pWʄ @)/0J3)}q#_#* Dd /[F<6E2^-m !W.^Yg@|㜙ɦӌ1u9e`,59'n`G# 3.@ZI7GɌgRJih^RWmONp!93T޴pԐu#4ݭQ lcV|! O.=}ɴcW76*/? VF`*maDB\X ,aN T֑;DD9g0DC@hmwd>%u=w郈TՓBXk BJ(H"cFc0\T9Q&{dA A+ذ,W5:gɕJ3)C۪āt,kџRRst1) !>w2_B"!`<4'olMeRR*2rbzإ~DaefۀaM ȴRJiBYi[9`R$ ^Ar1^o˰\ƒ0ks`G'3{WRliZ5;{V5 UUu]vm0[ A(1CLpuĀ ̟m^-+9`d R0S Wܾ2"2k)}ݷojjnnnxdxkk/zq}; R1DU%u#+dG 0xЕ3T<9$_L}'"Vm; !}SvO/f]!3FD7p3KT p,"/=}91߇w+?]<;f]>Oؿ'IT Z3ܲ6↹.=9mgݪdfvխPLi :kV.6UHf݉k,B&yRj SB҅|N2(΀pv1Z#I+e`/i$*5oͬTN\]o C4P|A&P@Ki7•?mhafgf׮QDFUKŔreI)eKg'JOquV7MNL1@IrnϯWd ߾Cqǝ\YY9ywIb_`;x SHjDZ[1 zB-L\K|Lhjۓx/LRfR?~ר`uܫ0 ^X.ͬKup'IdLUf֫`glXLUlOHJ ᓮrf{ MkC&#o "@JI?C@bGNml|޻^,xiY;FFF=_(! "ΘBCt8 2] E $IVk%&2$"}kv+[CՊ|yj0cݨ__2?a5ͭDߘ/@xoV{F }cŵS?hFhLB^Zt2JN/SpV۟9j.ݭgֿUޤe6_<7HDOB3?)#Jǵ[ r6eaܳE҆kfݩn{ (NQgדk\583|n2_L`f(6yH*`W8WtJ) I" | eԃ! +Lkh G4=Op/oo[ ׼0!*`\5Czmޠ2u+echj!O| 5ԟJ}aCAV9>z㞣'x6-볳s;TȋXj֛⩹ҍcٺ-l5MvoRƳy?m hnzB@^RRO` G!!\!.˳djZ)JW`Fcz F+H2@J 978omG$5PҞahiBpfW#Mnk+-VP{Y @X#v8KdL ̕i>ݹ_Jt*88=V>BR=}6_dx6|)xRplo1":{riaĤi;L$Vݑ҈#C Y"+vz8 i£6"!T\I/.X.+X3J0џet/ @xgUE=*}/F!kE$ArԈ|X?Te9d-PcJJ<֭7Lf3C-1w_sm t~Ea5=I#tB'zJҺY,WDzqlIg QC,O@BǘGAQԞz" ᑑʸ_@B %;PN@PWX:bZX5E 0 lkAcQPkl ^)Tw( Td^OZ-1/״J}^խ.6'dͭԬmHͅ '*͙^ar*$97Gbx3T2 4m.jJW)GH  6lWSp$ @0yf(ɖmbn-k{aW2m^-sHg q*P&f5C%4DV` .Xnr9rw^[WU=kNbaaI؆f( .Èq8ɠp0CS"G%B6W"ys 4tARD' yۆ} 4\o4zmq 4;֤PԨƝb *gF2g!mk97U= BKlZml7W L-Q_XXBʫkMhiZ;hk=ibщɅ^(;[MLF"1 TPD$)Y+ 31"%",%\dj_nTO廏kk 7Zo) ZZUW4 ҡ])B~}+k"qBeeO\qe%JBcS2h$^OO;LY !$%cb=SR1 SHOg H WJqWfJi \OLcAERH6-2ߜidIvvND=vm3!(ZLP&d6,٢6,my#  6(B"ġ9 5 {/y8q׬†Y7q9q0 6DE;g}*i5L"@&EQN/5'wH}|2yowPL.gZZC8l)6zFv w4댉cԗ+ôFov){ot`pasjF$kH,LHvti\EQ3a|4_[m)lomϼ MyN#-8B%T$ֹؖ9=̰KJVAB֖@n!3f.mQm\$f3Rv\)enJ=5.\ysZh4 ! 4]1 PqRcfEj5'c`$&XIF55Ewgw/+0<GW-"ΦGz}qiW pĘte9Ydw_˱ j* pL :hj2߅ۖ/C)Ђ酳8F9 &cٍ;+O~2(LO)F9YC@d?{kr[AW_aI9ؽGs?~|j- ǎcXێ9LpX82S$T Ù,a?8 .!ϾZQ69KYlxi&IiVӫ[ƙy$4'l򯐦҅Dl#Cn {ʪ E`,4O&Eێ/\ϦaHt b)j;;k4 Oj|xxڵ\I!!8 +HOR2tRƍZݱ@TJ8Vf۲'{kk$̤HsLKa۵1V*iM_&ljB8C3k'/m5Wk6fˑ̅X FR}t<~qx$"Dȿs0Jx5*xg+,J"Ip}鋝8 )se@Dm-uZ pmm]Tm)U;(9;qCNOOEP( [i㏿S|:{O~Ƌ0E{qia٦ ΅Tl1+@᪳ĕڮ^Xþ&8m?;5*VjYB `˳jiT^Djzl8kW Q[RG$RbeŔĀ%ܵt0i?ѪzhbJ+UskĿx2Yg7՚tF1d>smkԿLW^xvU=VA*i.5@Fq(NUm;#h7lдvy;u!91 b[0& TOico4Xb5T)řhj&gϽ|fGkN }]5~uqr FF2RD%uiGq`8" ɢ"H"L{:F95=l>d9L8Mb.Vx0}b#@^6=Pow>?[;2vU1` 4x-,+tdp0 jOmTW2@`J|U#?F`/W&~Jvb -ƈH*]3 IJkEZ4+jzFՆ0*՚[Fx "2LKɾ1kBū;-ɗ "@{W.\/ӫ//I`vs׻uэڥN?'i>DPjP||Ӿ΍dyn]RiV%D#McXAyr͒@:T|kzv@>23Ǔڜk jlnkvTApAZ") 6b76j{EDV8@۵p8Ӛƾs`fQd'iZ182*q8oLdOd r3b$ |'+Ԭͺ;+jUB+SZݖZ/"F9;9tRVV3F>0!CVV;x4è55.LfS.d6 psm!GXYB6gkN-iɕرM3u\jwH$Sk V!Ypj9é/?sH`Dz̪%M*MeN !硜ҏToAL$g;ih0∩`Li4-b rWa;vYK|S6dս`Jek8bאΤ@eիV<<1Glo4Fj©6VVwV=)IkkP ز|9Aۆ4ҚVk=jB"jV'v%sȢlf zh~vXnH STㅯs+H-Kfj* |u6@lԥױ7o޻zpwkc՗_m; EHI(ՠ 4" oo6xr Cp@(m4bPDTuzx6?r Ѭ瓐"m<g*vϵfrK]L'h6b`cMGh_OG٤QkLqթ*!UR)L. H%^|w|) aaE纮{GnޘΦՊWq+Hh\+mVɹ!WAtZ턩r ^ڔ,tc@dk;1XnT4 AkD0UFCap''+eDV񤒌1tʱ"w׆ɚaiceݚ8Jٸ{ J" G0d2+ӔazC„ EL ? a3B}L'nRF6͟sPs wgy[VXŸK.i}7{M^MXCK)Oh ߬[i!neG LzW,CMaBn%8p4[eb޴;nu*Atm\Qb{[uU#TǏ]׽~ڣǏ?7*t4L0^y۷׮Rk9(9t1WJ45F$̴nQk?oʯʿ?xקkժy^om}]kǓa718:x{m ~,bg_a`VRFDTF%B0D 㑔zZK`?Q{6Ostfy@I!ݻbx,R!`Tj<QO8L.-}+)kfrw+9 |sXInȀ1'R+@ E!# `\)CRѬ>@k֤`&-RZ1RQ,kh-yz͖km(=YTt2<Dz Y`6%U' X W^yl>tRk4(aCJY٪WH h{{[JVhmeqb1魧×[iQ5s[\r>x6:⥍c= .7̥n(>,"ީUn^ڋ/攬(R~~I1V>ZY5Өd{2]ʆК|%=}t +%)ED((2)QX`XGPg EȘ`0!%֊g[pf S%yE$!i PbJ+%57ĜjU++ukkrO gj7|6U/q$L2eFl1e`XozI:V7Rѩ$_? +ng&A$"T>T{,a˸wsM+˓F%HR)O \0'WT|=dղe,Ak8Ru0_,NgmEJc ۶4-C @(&ciõswSWnݟ(!5}J]C^675UVjxMU;/\2w I'!B (P$@lg]zn(ӡoW`cBñ=y ʥ@ơRclZ:g²MWhn4eōV۝ыR 0>ue N((z;0٦TZ0bP$scfq2@C00j!FBajU*~66~곟JBQVw-,;(@q==>7n\ăǻdl9&TTlKaʖP+-4 X0#? )jYE Ui 1 Y&[e )f(r~% aNL4gs8&B nBZȓ $\xBkIIlVeN˲^ڨ_Z*ERzѣOj g˳dv8_ڛ<:H:/hX`dFʔ).M`d@VRShm5@VKъɕdn_yjtbn4\V93X*Rl xp&菣?{2%&+;kZY@+ڮmrHj~V[퉚U;LkA ʛiҚ$nw<wZmm`HԫU Appz1$!)FI4QU;rs9&n]ݩ0{N7学m"RP%/)ѳ+RUTܧ.dIQNv*7'!bɞd13J*\ҽlla0s *j(L^\WD Q3f $R Ɓ4C</6;UBj{ʅ1xGFM#)ixgwk7\b % ] X%XyڥVKM4 blڒ1h7Yzp`wwݸqO&W/QQǚlCtEޣ= 'Ӌ*U2a-4݃Z1EF4KwNOm/ f[_ФwynZx炶\n\ljhWA)Nc DUjsNIKHHPRٝV' éԻ^sc[[5nsosy) `%Bd2Yzܽ{r||>8- "#+}2b:^Z5{{~|mAR?띙F if~|~x0>w>[Gh4DAKi޺rH&jzv>{jڰꮳxԖ(qFKhTw P*YTz!U=õj;/^/޸|qwWg&_Ӥ?:n/bY@[RU)+qeBB % E"sJA~:O.&so'9ܲ 8߰M3SVj}zjqΝ;QOG~VX^?[[ b_4-_37/@suvuWnno8 'A|o j?~{28'{ߏ*swDgWt}[Nplb1SP,W.Ej#) lVݖ,-lXz4#.ru!m4`gyr[IB ?N|SVhL!m[m,9]~O}jf.=ykˈ2? Cm1XKS'0p2vV+WeQc۴SCVTX,sC4mW??2 cuuӯ <;>o?k ߬~3nwVFRyhgx?=Om>ȓų#ֺsK .Rity|\dEo3ύ8w'>zm\|;+;{ .oNcj}?5X9ZF_r2Z,zfBH@fE`f>аmg?Bpdw.]<=7M{+isd^H8FD0bAW5J޹?U>" `iJi@ӧbiǦ~{wFσP>Ա"3YfI~6[Fٺz/\|nbޟD23c #֚hnqN' b^gQG%٬bRy^R٘ׯPwv.lo-8'QѪ80g㨓x>8c۲xǵ]4O{irh2L&Np8lnȯ59kxpִg4Tͪ.&W/oL7OޟJNe8ܕKnX^!L}S.K)C,JYJݪfq7cmJhT.vWvvֻzQ'ˑ[6eiB_ Dz S ! Ї3Sf(TI`Z" ّͪG'_tfC@Q/1R`E4ŵ"~|67/kZRtF|aџy4cgd ʵijb hJXE ~ɃG |w80B.PaR /U#9ͦpԪN$hC6Oy4 6VRr#X=XJ:!cpee^zǝ-P >a9=K7֭Ӄ aq}}E7v6[}aV+a, hSͿeO4E1S;WD,꟞^~0b!ce;70HZ)hR"LUiY&Vb\e lVcmVvG1 Ҟa9A@0mðpEZCD`dkk$B]QAY8oV>&rv^ܨI~7A2,+)bYoUO|cكɓ)ly+-0+UjiG~T  ?u*?Uū#bZw,w>@nJy9W^001Me,V+dr9*HIv]wH-u0,4ȴ~/b2L&Da~e4ڑھҸz|+[[[o=>~$ϓAn`LEP*j c  J4=yvο]tp>ygcs<"wfyRH>V@9@ ]o3lBr0L+CY-">朴fDZ8l9 ʕ=>n<nn_ۿW~??97?~pdE 9NT{i;fL(˞=|qcްQw}f~iQQqOOFϙ0ҪsaUpkTn؇JŶEeơ$"Emi0 *I)WJ2Z`6UDv2?< Rǎ0۫;ohNNO+^ms-f|2|aZ˭"M@h#d=۫W}}:CUB?O-d'7͗VŸ?o;Jjz~Xt}p $)?++?|睵5fifoZ hԪ~z^-xs+S?Mhڷn|ѕ"i(*NΦo=Oڵ/\vWw.׻giG|闞 @Ԭy陑V&r@RID8fbJ0+DJk lnoYZdO֝ۮfӹ?;8xio|cٳ5a l6X= p(ɶ?|Lˊhtmz])l6W]ױ7!!k#΅GDtoLERJk}{wpax؏=SQ3 &Պ۟?~:ho"-U/^~4 V?[s)CK"HLHMd_k4E9S(˨Vdr¥K0ʛwC&Y&: }vl 1j`ݞs@nAp! bLpX !b1|i,UVF9& MRȶevQ O˗YYmZO6ߧkEP:sKf˪EI ONNN=3 47|soo/Y+}ps?g/ԬvODH JPNh8MsS LJ֌2-Wh9)PlIRJ򹻁-?Õe:kӕnwO~u 5Ȑs5ѓ.(1(!EԦc) Җm)?<>88ggO>͵&˶y7U0V;Ùn?Iz `8f^8?&E8XIWa|> mDOfv$Z bE36jӓ [D`>BHK69wﮭjM+m9xL2l,.3L|4 •n(~iY|̑6!rόg~܏PE`;">byu[ʵD ȩ 8$σd̮R6z*UTZF615G*l WÂXa8ɞotlwݰN͖mZ';UF1$17o~wv/9Ȗ<=ETf]υ9Pqf(X[ibK'yH,><µww:Q˳ \˺yh2nz3΀OLh1!؇cDlzN۽w8 "̵2(KdC!k=}n)]31^ԣd a]K,BY?|ٳ%y'}}?w{э@DRVLq1p`%~s(a?8HF +n߾ٷ:燪saqno}Kei$.ffZ&0 ᳧@Vqrv^T\5<۴O DSfEZq]A"߽[Ww!|U pvr^%ĆQi^8٣jO9WeYVZ-iGIZZ폾L$ .ZEI3MQaQh|Z2z PXO޺Zn/a2/CAiPZ-6?P Ĝ7K d3 B⩚08kWn,UF%_T2٪g},Xr ~+/lcln~` GI٪td-NZ0rEGNn.˚/,:%5=d4?(xe NnwtDôVD@}c..^/zNDQrOO1B|qTz靛7 °V)Zm@g !f"~gNnݰX-Wç.;50EZNNZm~~d^1[!}맣gs΂vٺ9#Qqh(-e+rT$B۶8kʣF<̽c*Sݷed>8^1+^a,T,SSGQBP!$uS%ފ:F(|Ѿ]n`6g7BbT|Ra;5n0?pbz>^5qGtszL&NmͽgLÊc[g,-0㓮JziljFQ/4WM B2޽"]Eĭvgó^kFqh.$ixe? ` Ϟ޽}GH4+F~rqѩ d" Ƞ8oCG޽C4\W>:^̂"xm|GITadڰ6S* ZR's2-˴2^ amڎmϗ^Wr^f} 1@\{?htqnKʕ ,A*Sܹ| Lƈ!Kkj, l{ASbK% %A(CE,GrT,HbC"(&n3Fsư^ݾ};l֨ :*Uz!$33K#V^P8{6TE+/k %IW;e0IZVK~ʵbVvK%UȜ!u>赺J91ʝ2@N~x{{O?k4ȲkԻ֮:y7 qM]bU5+ΕV9YOxZ "Ce7yfw[+U8Nڭv!Vaprz[&jHŕ=ً|~u UZU|~k/7~N{+i G琦*[/Re2@t@\ /#MbY<A߁[ !R|#^XЦq(FBU_w1L!gJjl~HEӧOyB0iv%sV-GiGC?c&B卥#ewc97Ҏ̫nl8(o\md>ʐ2%-%_fvcbVΦ٨V$uJ%Ջ 1?\4M8ðh4[^W3_<9j6h6j aQۥ4j+;~@%._>ȗۏҿvgY>z=nݺJ7n|_a@ۉx0|fagbxqeg1I &fK !@{HzwĪ6گ? ӤxaHZ~.c]:5)Flh  D Jc]=%;s-wq-.:U'sӐfEYRq?aO0oVY2y>W,KBhxo>X; [A|0X]$ɒXJSO5ʩ K lKP++8r=2~#ۮ<{''Q:nTvmg47*|*^j4̵^Kv9_!g# {V`/fx>x{f=0^w_Zlֿl*"A N?8F5 Nlō7=zdy狹l`Dl>]"jzle~~XUx:]mۜ!yatƏo@(;ఐeӨFRR?/{|e-Y5'}W)7~38*Q@;R8YDqU&ɥpZ~!@@Z,c|"WHiJgΦkX+߾-ONK?.9ٲ{k#J3HHŲ7gXqMD\x 4rJȶH$#1쌧JN&Yodc q(Jh:Wa b0\^Rd[vO<}7L3 CTZ{^^+h\eDË VJ[/H=TA&.8kgY;;i.T2D~nhe2==*"LSe´4*^z0RlrΏVգǏ7y^\%I6cK% 4)'d "Z ת is@ّDKƣW]~mGQ* *鎢&AI$ "j Xc-]ܩ8o\m~r2OShW;UFh6.:ןD_LDd{[pdٳڣvU*I@5U86|$9QP$phƇyj^'I2;{ppڶgQcn|NkqO@ .>6[GZ#"hpdQʀeny>X\jNt`Q":V3/(]0"1ĉ9_l,R6|l5 14$(;xy0N > C^oI͔QD2"hD!vr=ՠ"І!r(yFm?}pTBeРNJ!Q(R& sadzqMNsUb /3| 3?L/EZ),60.wtu߸)pjX%[? 0 XDs,2R2"Ew.S2,uːUB%RѢpRW\_໯wyzsWSIu_V`` BrO/‚@3=u9I&HyŢbl}8e7: I|hz@N@y$MRrl%@,y,PI1"D<#*T8IaȀ8{^q\LϞ}Um;]xrpm .?'m;zVq e@$eHnA$%vt6cbaYH_LD.HLw27Ñwo٤ kճiCho@@?U^Jl""M/oݺzx-x~X|H)Ry%d>HQΗ:YxxWXz Ai +dyu>`ޫB˚S8l,-mT%4u-]0Dtc?ׯ&"X(a&齽|T6i 3Fٹ}6Bz=Hd>߹z] IW'$ }$͓ ^ Q\yB $"giK`zWW'st#JPfˉ gh)XЩvJ4*7(6E b29|^&H$MLf" !"w`WwfY\M$|; 6pg{g8qlөNj:eZ&y^:Yqe%BM6yRz0H[1FD~N[a k!asAjX㵻p[+N+w~-WLd0m3Dg)$. k$ǁrPtSOGnïˆ2D)[26A59EujHn]M,.Ɩ"tnnHL`(eҒZEv3%SZR*Ygq|i0lV+4 T?Ͻ!C~] 똄.n/O r+kӐMWw+jjT8&q=/i6uMWvww(>j!8" }3 &"y-;Vej׊dG)cU]tS_%%e: >=Y|~&gӵI$E$%Dޠܫ^~LU+u" ٦X8_Ŷ?zͲ'IjW8TSdOelHHKyͫsIPc E K.[j垀$}#Nj2:VBMwt@E۪d I",t!?|mߍWn ڭ߭E({`WA2X&V>΃<L% &OE6"e>9soe<ζ[|/Vp,w4X%{d438IL/Z}28/;Xyv0Y Hp@ũm3"4Nc+{]ve8&|<~#Jf ,X[5I *`  2T&‹ϟgUs6? !I1lVڵVͽX?*J<;$NCE _H5LByBZ)9ҜeKKunr*)# 'P(b5)*Vcs8qveX`d5ORSl眽z #OVaB Rj,3i_9Ȑc86O>E^R{ if+Nώ>U[V-{O5|`[|X-W^,ٳg/Y"!f YiMN{_IJµsǏ߻5b8ߵ͗7?T$rE+̭:`)w/F뭪{6_Q5V~,5^H qZߪe Jl"xt:2WCD'_s0\B=\(^~oPɵe1\ Li@ "مEB%P2V4}zi`ڨkڨ*5֝^PQ Sb&]J" \ǽ=>_~f}&o??sx2Tr^y_;O\ibFɎTdo6 pPbgӞf4۷yŪDNo}zbdkTj\N{ gncQղt:((cժ 0:/84[ur2Ur@rm9;I_^l`^7~ps8ѯwV˸/ȷoF) 4ƋPdY$k+c?K,=* ~]Z`sV.(2 EDm`hh/[OVX!(PQ;wn~=&m^" UHOx*E(K!Jep^dߴo inʁO>.%Xx+׷ Ro0J:Lvww_xA{{{Je\Kx1ލp/Βx~6FDik܋ZOF/T`+d&2яrW/[o΃2*T1$ˀYY-ar@@V*/RVS9 AVAf!LrwE.J3(7*@ӺɓB҅TSQL L~ |{Q[uZͷ^{-3Doe{ V3_]WzQh3Q.CYs]e.b5J9d""z<v hج7cKzF˰reH Һ6ONƷDk;DSvnAd,B8 `f!IYο=PJ hiVNdRATM/LhŃw%N,,a!E*wkwwj||6cu$|U$- fH$ "'yZfTqY u+R|Qx?~rjJl!}A|c7euu4ܬ]d7 ftZȤxT*NNz=亮چ B$QhXl1K|pkweV []{_>F%ljIނŅ5P) z|~<_μ01 m/FYEJ Nqeibũq&k4dȑGilp^.4 4Qg4kqZ08T\ID@ -@]5f^4",k7"~Au9R ;| ΒTn5sQqCiUϣ"\eauK(!N\؃87G_QHŁԌj,4*;Y[I2 DJM-v>`0q{Z-՚aeGO׶gij랝l{"۲fyն_+l(wUB0Ӧ]c{yNB$Yp1GOYyƍ.GP/[v+r|j50bEee@T8e,ë{W`-4Nj8UT_<.7sI9PHBJeWvôZae)}ߺnadؿ}v^r3f! 1Jf}AU(VXƕϤBHl%>Yx~1w`\>xxXroJ.*<Óu. =K-E%TK/iI RV F4*P)f$M^rJc4/O$>x1pt/*B%Жm.+(2:غ_>G^dc;isVvH67܏Y=MONv,e`P*9R!l;>Y,oLfN:Uנf嫢4VJ49/~@Zcqz3L[)w N?z4? /x:; QjӇ$2xFdcXhZb]0øxxg͸KIJҭi& 7G+\E4joA @^؝rdo\)6++omuxq֨[v5 p*!MEձ MVQT2MSaVjiԶE`u!J RO!ZA=8ǯ^)jep6붛Ԉ41 +SAB´l|M"bU?iGz2|əfԫMnǠ6o>: Bѵd<2MR*caZZZ}%gksULOݝZbfñǯ:2p,# tL^oRF鈾>E@[ yT6J1Zt]]3 |DMd}#Dkn"9$' م.&խ9MMf~Y<۶$n5[J 41ئ'-,ˋ I iBT Zi&i*l=Xd QMUɅҌGEMRʼd1")}pU՘̦7aJ879v}';W-ì {p4O(/ / _A HoXV CTT~4[. /A& J:ѻ:`a(lj6i*D\t:?{E}:T*R$'+"X.~͹ޭ7 coooZqޕzMrejHxK#*M<Ўeνj6nSAQ"J6-o7Nž٭TlcGEXE+?^$ Yudbip*XsM?L(MRB@ۍŁ Yьd0088hZjuVGżV61$H0OlH+w%@m78fm~pS@@ 2CF܅Bf!;ǃ;걄\ (ERK,K)N@L_qS!Z''@~g^#HD00$ߨ\.W9szzh4.VIlE A.0b.b)@F=H`F888x 8LFqlQFm2T-i /|ْXFprks9ߡNK(& ӬzYGcmS<&eD-hT:!Q'((jnܹz>cnwr+[mGk:D 49PrtTS:Bfe4Z^җ.r(Xz59["/Nsqzǻk;xI8sĬOE$Q7?XH)PN kmD-""j93'픟\0U,Im^kwk7BP`soѿzl.x ,1$ 5V V))'8w8؝F 0ԏh WOPR ʥdl~UlfM6UmV7MjU*6FOwNAbV%$H$$0IpdL%Qlpa'Ilq1XꓣJ72_7l>r+%DW>;ac_x<{Gǵj%|a;i&cD 1^z<ң6M+.!Q+: h5]t{O?~ɓv+^6kԠr1:Nxu.xUת;w"XFG* w˽'K<֦aeSNQR2Ү\e62o_y+M!\mv=yv~|t!yQx5Z/,Ցנ)9%*Mյ;d1^z[aU:4*#)-ӟ߅܄CMITB=܂EE6V6dr jPjiJ4ө5, _w^/Ŋw[n\.N' v9M!78$IRsf1:L@H:4-r6ɦ5\9j)o/Z-GF׾uJ 亯޿X ZkOzfެWF`h6/6pga 姲cy%tey4hQWZ0ρ@ݨQ-[!Zq`$ݖ{ol A:2K02+TRѴ% b!T߼{Pb(xQB) Ni>HǜEՊN'ݹ*_E$@lԤ?xF1CC@FϞsי;[WLd%挗lH" Trm֡D"$E Gͯ@.J䊎PiKUyBm!c".àRON$`0*h|]suJ*CݑX.$U$]捌c998 z:HN[/ Nv2C@"L2Mo^k܇ә(̓ij\̹+]H;+%pJ~CHIR\k٭9R 5n 4S7ui%$&@VA$I~] DE1m4aμMO A*`ԑ&?,N`u>[}vej4}ׯOGVV/N;%q%yD-|JdȤ닜0P5噏Ca@91 v]ZIF͔d-a(eάL^Gqun]=bJݪSs-j$:%:,IJ+ZD|v j4-,h`WE*HMo8_fYtJ pz{^2Rx(9W|*)k IDFm1"0+R6 GFn&7u NLf؆&QpJiqdj"R?C}:6/pl㣟͍7? h4jZϟ?Vfs2|E:tuDהIB$$I[)3MoݰLk0xɵUf{Il&i-Gޛ[r%aUuэ` .I4tPd9BR8lVvmɔ Eh5IJht~߻[U?dFdbyKUnZQO(&).BG~ɧ%S5L&)hGg-Q T7gkڡ۞pavn8* GG 3?=l5? wB.yWcDI R_ȡ"`EHQK^y޽{z^ya&{xG*pg>}nBxK7f v@+:6ouθ'z",Vo^_xOPݵGn)LIsH W}}kJ1GvL&!_Ø(czV& ^؞_W>&د-O0f/؉=DE@J\{Gn8Y. T){6(}lҺ!(;c`+W~\\5{ZGlS1׸R.7u͑NTw~qqitΝn\HDL6?=h^Ta$0|0 W`npY͌&F位l._X f:M*Y+!QTpenl? YWWV;h$x/n4{a=4 RRye{a,M/։0P؊(2,HTdw{.#~BC|ҥK.{vvva _}_|qggj/'$_\u;z.'f|3H+: %!- 6V (Ns$IX)>`qF{/6pR5( ]qkljvbIC{<;/o]sg= /qCj㥹A8l[A෺le _s0[ !,! :)QNN jv+Y;=G A0! tyb' “*g(N.-X!a[q x{]"u 8' 8("m gPS6G\k jC4b6w…^|qwf(ʥrrzf¹f>"K(~6l:H~֗h`M\HwR0L':0Lsw3KDclىMkB6)t̒Au9(R>ȱ'܉\[>uvZZZ\,K@ F z~Hq(嘇[IYjBD9WS}~X _z/q0n(LpEB_;QXΜTC'Stur@ lNmUJ1+Qݐ񺈌%t{#"cBr_3>ڜ2aɩ AQ.;JП (OM~`0U*泸PCO@Q\jҔ$=T u+iL)`.Ǎh1? @H6BHz?(y~Rf?Z}: Lq:k]dT9DIe%8U3J%NuU !u3\X,eY6B r|`azfD9" !ϗP뭣{+w7SDž|n{ZGְIv.5)j~7b?(䲐t;;|n;f2A&a&nwű?G}%12.YY.]y&ͣK+<*F0,dc)F}[w׎;Ȧl.%Vgئ6י<ݚԠ' }^nbz3O$clqeŸ[%(8\DQy^691ꍽͣs:49E9a'h(]zd$3q¬;ߕ(l%BW:*\;߽K{MdgOs[ɩR;leBb"г@o~s(@c0^FÉ*0bj" r&Oqfq]fE j?ԣw6lX U Ky- U6WmM>-DjJ t!2~HtAvj~.Mμ~G*_VVNw)d/<:[{3w>, :w.?y2ABZxi|֯e{n g `cZw){n(E%+qBw?QkwWgA-E )X]v#&*eJ5D~y A ZZQ!i̢{;=_4FF3RF"ޢp+Ě"$R-*j3Y% 4w R#N96K@GT!n~;D|g=o+[KSL4DĘZSWG5JL3<ӏ9GȿbD?|Ƀfeh喠-4 'D%"msCB1IsO,/"F;䲙[{\& ˜n;)>(ocs.Z64raE DR26f{~JN@G#}9)p CH,Bj7E2iu$^jE[1rwx5svVP ?ب=}jjn5:˕EqG |.! dv\N J1LyU<K%SQ[M0 \H|s_F'l֪d4IZ 99[4B@k8QE?nՓU"yR=q40乹!!:s)S*qs@bYqӡUᣜT$">DjG^<f VHkjrI|:q &ZX|WSq\i$k/&DB Divvv8yMs`tf'3XGEA8;i#[&)ȑx;q3^]{R&Snޣ\#baF9?=JRݮכ+++3sqvUs"L}(̀h&Pī.qGsv?^E6?|RڝBi J3hnopq<vT N^JDHVf94ӥz2NDbs[bAma=60u~bFFS)gf5WMƎ@&@c)es^'|*ͳjUiK7,er5`#ZG2v%{&JfQ6 !5`KqW =oI&qĨxJǐcA.M$Lpr}\9ͼ~}dXVw3g^^33=j m(I- (6wAYlW(C*W6 =s-0Q\J\e贳OT 8]n:!N:la18lxRI)l^H؄yA (U:m$`l$ 6hF^*vgH ƅI (jW3/n` >$cP8G.]`XWZ~ {RNBP N~\ا0Z s+3NQ7Er[?E!`ЊL ڞ)ht+;D ɉm@NuD19H)QC8*9 ~LƴSw**,hξHLrv҇{H-U!e:DN2E 4t5kD$ϡJ;AN˨ϸvӘҕ5rkyjjlK q1PWk!op'c6'OLMh~Qx5ïT7V Lc?Iaq@RzTßLC*2n7"^#cSj@ BFtP ʷڱcMz1h/S::J,dd9Us3-CJbH*W׹H1.@1Qh`G)?r&0_ݪn&d \dkJ6CWJ 7k_Z 5 E<*i4I, ${Tq`W0,'6MNt%3]bpѽyE1#z=ӂMVc'ait٢&gD(qC ^R&0<"]0jY ̶W=@G5=(tF+_ ϵ!JFHD? Be5l |@IR!@O/w/>FDv[lb*lz7 'DK@̫?N&*ճ!ѮP4SIStlXS$'/ ṌrXfJ9yCD̓@h(E]ڡhP?'rfX;SwЬJX mh,d&66.2ǜ^qZ\+ q&ARjFv[ո@".sEps;qpQ~i%(UQbq7LVg8{pش,zgM236;w.3#>1l|ēsoo: l'!LwaxH_?.gL7(6 l@T>-BSj ݠhd\mpWM= ?VНTALZ#= 3 q0ʒN&,kF-f=A4{lrW;P㭣F!@ Ul|c%ʣ-ΐ1!).iIq@l4N,ZxIjqĺlef}2JG#A(,Wi0%UVw`NWVTw `J#OGĖ10z~o`HƯJmɐH22C1IhUITGvd.mC{$K 8%L19&C%Q"}֌<(Dw~K@"S"CɒWxZ!D0*M62:%hdm5*Vb}$feyUKLd̺&ўr9زHR4f#ZG$K;s((Lc}@1/.6kF1ak0nL*+"sHRg1đ.ZX )}U]JQ5"1RIN}ZcheU^WJ0$aB6n, ?`YR iO%{Bq0Q.ASb^=FevD˟nDSy5 35wj!J>i0#mTp}I(Q$t@xwK,vT 3c#AK Ǟ7'GT[KNrAD۟cWЉp1pY[MPtMzADBa-dIfv+ ͙B#T H<^Z4C0Li+;Ċ,oV FHtQ 2@xe>yJeKa`iRDz\]]#L&f3 t@JĹ FgXN$c PNoxic a:I_ ?Y8'g'xh=ac S8X .3Ċg1d2t ⶐSzӒ:"I(BR1D!SVQ{I>*3G cbWE K3uC@RZ*e=j#"ElUx;6-Қj.ЭY@d+]-~ŶVD)!]׸Zgo#ռ{ Lh? C#,M@ЕhUM9p> X -$GLH-Q@YUKe8#G!T*Lrn .k~Fi-31N,ޠ鷛懃n8A&p Bus3d;ލ+o/<{s21qݜ]\IoתӉjb[tK;Xc1F|2+D ЀC;afHDA|G D}_6WsmX 9%8̓.ۋڒG PtnL:K`_cL6gMdr沪'ΉCa&b*qb`d}ZSSTBKNP"`^B&Xӏ;sȻi'!Jy*ٚ=<^<ϋPT4ӇoOÉUjB1vr_.v;Cֵ\xև+es4U[UC6A{z>_"- a4sVemsڹT acɸ,dLNعk ƫtݤ~YN_{duacC5*e2~0Zy7q3X8$O`z"1;.䞌 1D97/t</GUF M¸azg&Kt *Ӌ1[P*dq~&Ug\cY%O!b촚S9fW`9{H!f'˜/h |W^=|"tFve}rb8ygoSWo,?qhNXlת/$.\ߺ;^'tGɚ0Ok5zǞ07m1yڇ*7Ej%Y "fY-),,I \)Hjٌ ojZGn]f^5k7d3&I8g9`d^y2 rP9 qV!İe몬UbݿO|{幥ӭ҉3{[{[bygsj֏Nֵ޻ǟik8n'\wRur( ^8 Vx[gzwQLKnGQujNL4v1 a8d(=K3DD1629#+aM B߆4ZY(!o9;s|.Ns?d?^;Kwk޵/x|SR'/V'̓`0tn6Gd3p{kýl6??;ѕ凞Jo~&%{`榸g'2cajEޓ@c+?2O!V4N'Gl3-b(b։j-fja xqhs[${D  8cf }k|qq+[wLJ7;3W?^]\=r%cDdsv3(ZT9ۺ{~m5o^}7_(ysĹ˯~wԋ~( nvv}M:f{o|gnEp֦f=v߆hC Q+㠍Щ!Ny7nX8?vܲ׫? #oIJݣr\^LLH~N{jvaeifda*7g|~xvy 03N?vP=RILf=0`@)"-| !Dy8nۤyG@n^SCJ]0]#\RY~ i!FE%dR9 MՌІJHEц).IҨƈ;&uTgV{NmcS~Dn`Z6&C|WJ|Vl$I#RqJ.sȤQ[Rw'zE)WJL%z(q1G)Wj8?dbDQT{zt] b9CGtV9cCAo+-M MLC=u6&s L #cCKGM5r{ORib##27咣8lq#>Ғ#%LSĢg8cGđ8ydǢ`(GSر:9OLq󎠙NXGAI Qz8JQS7(KH+\1&Yr\w SI]h9{SSF$7GM]#[{z:Ӌ_~բG&=]!eO}m=7]<"DCe;Sv&&YcejYdgY5v9nh-|y%?1=T%d!!*Z 8ڭ,"L0_rYcwx,Le:_'8DqL 7a|gjIrY"ysDQ,QNSBiJ0E&(|@"="GjEP8t^yY7$\0P(Nn.Ng j)`ǿGz"V7\*_xzrQ-DQ FT/0 `iJ ^% 6s1U 6<M*NkZJg_v7Zgw%g L~m8Nznlھ xB{488z$S|T#rH`dHܶPh)5hb84KDl돟)Ld/}XۇvCΞXï]E1e|~3g .ÿwk?y}>y/?zws~'W]'~Ců[ʏW7zxy6W-o\wgt@;S~VG[wG~KNW3m~3_d{lJxcf](i[5d{_Z(gU?SvGS+??ʽF;a}omOU2onNv7zGO߾Ѹk~틟yzݛ YY%r!;>,ogk[ݫwZ{ǃO];cW,vf'_<k$"׽GO }̅Yhv{~|.}Xb/ "YSKv z{"&J ,]O Bgۑ$B5V/@:at??6.ѿ0ssl[)gֶ:o_o矞>\ǫo^> &A·ݵGO?y ?{^FޭaX{q`Nows ׎?瞞nuKs_X|[;A&p?1 juï|{ԉJkv'<69^䅘jiBԺ=-x3*(_ueD8l _~{'UFi_L# [?K27g 4/-~k~ձ^FG>LO V8Yd%SkB LEqlb9sBez Y(dN>/ {;7\q.p].ޯ_>xF'fr@[%LB%)KOM^Q*q+hiH0@r!hv"NUg.煥$|fIIڟ'[bvDYt[r*klkF0Jg+r+5߃avrџ( pm+?\J5 /{~_o7-G>n$Ҹq.ݺf͝]bwv4г3㿸7W֚fJ85#׶e&pqbn,BWR3%Ks3_{&=|~-V7yB71]>~ٿOמt⃵œ%0v/zl065ᾇżک_xfj1aW77; Sϔo^\d9Gr!(}o~VoVa9D^M$׾o7~#J߻# -Q W ˮDtOw"SO 6lHo`%F{{W77_`Ib^Սgs d9{ԟ"Ѡ_G'秲Atf8 F'f`_o ٌ~<3I?V 9bvӹZO/9>?])4;L5;GJf6hwDnmv=Jy~*vz'v8k|> rs_βI؊ImCʸ RCF8s+Lэm:Hꢧcg[g$t8'5iʠ :ΐHFa]aFL4b>|a *,>c?2/:c#oFB@uMЪhǢp8`UtYr-}P8fCfHhZIfx EZ$œaJR>iȸl9뻭SbWK/=y˗??W}߿kғo}_KK O1м;Q`%[rjo(NXTU`KNbĩs;K$a:A; =؅?7a"kpzFok}[vz][}{k0_yV_}J7>zwQtHىH <T[uAQ:\<)n]ەCWK˞@!ctEnttFu;@54OQln.#6qCܛYrbU_====7 dHkx^o؎B6jA@ `f0gLwO_wᆱ*#_e}U݄Q1*2+ھZ` 6Ә;~f6 Zff \[;Dg4ebU1"!٤XYx4M~G`8yRA2N(jycYdPBcg`-Pv`.A?TbǬ8 X +S=N05?Y9ݰ@0AqJB8 Wd hh( pH!;̎~ZA/aڡL-e91MP&mAsEV Ǡ1@$&Hc`Ҁb-=۷ 1H~`s} +mX &%Ff, 2 lz)9LFNkPdXlxCDQ{Ù3*B#c'MJóg!Hu]BNt]C]1iBa4׃Bnͯ1uX!4-(@*d#a8Ц^;S+v+^)Vơ ) 00~&Lh )l(L`8j+f‡Y>c&$zlۇIo0s8i fjۏ"6FZ~$A!>,4VB %XD [_oԕ~BHT۸pa$'h42Bϯ&鑑@t:"NCc>x,X"A͚М0! q#Q,9Y Z +ڀ!r@kkP3iDۭ(`,LDF%9 X1 L : 1"Ҹ'$XS"6'@*L J<nj` nqN(IexA.x Tp&4hrvs  ιQء 5z Ylzb~(0uʤX~1K08>/Ao n*w3h enr&p F# ɕ &.,#D 1Α|]A&_H\"ZXaXA<L`갰c*n H[b 9|k-UBFm/@OB4(D`fDAi #ءN*:(pyɔ:43ŴYeX1(6!iJ%M& 'o/ܺL$鄠_r޽B0aLE Dob4k*"HSNؠN[М`0M{0 m ,,)abPIX4S Д#26Saڷ懞 L d (X>Lbz NM2 \d8(03HZĈdM $&@枡1w  M_1sga` H$$asGV"J\uf2FEQ_4lRZ:8&ѴIKǀ2;P`ˬbgqڼS @$8x%25AO0#25;:=S ]i]_ .ႁ%`A [л#Ed sO@&:/Yj, Po ,R"io/@"I GV+\4~"B}Mӓ|弢w.v!@|$p4Y  Q@ayS̩; R4HчQ†`H69Q Z Ѐib+Ԉ[kW6b-F^[Ui{SȗE>, [ ӈ0c>Ȃ$aE| M6r;EP O (nuƢ9 #*f}`DfKod``X\  Z H0DC pSt0Xc~ `,kEL5?/h!t(!ů~ݻWNd2h4;:?o~:B\ŎR%wt762!D?}66~υ cۇxc\΍Z( @P5 Z,ICB"CC &/YĸF}"Rr:Ǐ'kkk{Z"j@(Vǟ){eYY]܅B!25544m8!40 `6:1&kjU06嚪A,])ƦLVTuL9x cca]`߭ó i12@<rGʮ opED¥6f-`? /_o0!$᠓pzD!9a s#L_Pt-Q01`XS  t B۔XB`ɚlJ(4^xn2/;Fs 2omc>ޔޚ(fkhdI6=zB$^8G ]`mfO-1&S6yd\`SlL`-q2| ӭs3˅ ,M3Wσerf(L#d+^H9E:>wʿ7w tXs-Z'<>m 8(6V}ֱ)زRE X9ȉj51&,eLD!~= NtqcskgJ5¹pyr/^:>3o N̳pgwvXXjXe;1TN`7P/ff8ֹ pfaj[I[ UAi ;i5 Sz \…a$hЅ>CSeІ,v.&m)06XwAA)2.3x-,\y2/ړ'?Wg3w4Rkg}shTQetH++k!㭗bN^r(\ȧ v1~L }uCP[;]@.07k(%l{ߐ*"\0ա=M\$papHH@@*A (HyL@ 437:y~X0[ 0b4#swǥE+u-P]֛߫3W[|c2֥Xwj'a|lLs#=FufTkgC\S_wa4pq,vcelcex1 PY@ V7`r01o7Љ4nH>t JЀAbN351j㈉ܲѨI&퐒 f&%fiwh?ۻܛl RLW`3y7o(B30? :1|aO"k윂ˤ@|$H +USFB~B6aá* m cMS׈-ȢkTvyUD'<1O),⭚tSFF! 3l"O9iBX\k9dh=}O /(0?@ '$lc81Jx,.AdN]Q0d3M}Ll/(Aar`0O2n FP.L;S}><N۳u JشAm1I0D %,.6>qp#q o7jpDY1,jL /C  O!d330Yxc0 (afPD3f?<K;Ոqm`(41.=&F3m'.6PnjY81c/도j[k,@[^dj'~VZ5szSZ4;kpRRbCfy ~ VrA^ W-B!JĠ6+p  ~ւM̳q ,| & *M”Mㄊ)п-R>50J@gH!qjYpy11,,hM0AM )r5!ĭ,\о0bd4'N&|Fw2 ؖ_)B*dY:B0Y[hbeI" ܜ$]%_a)I5IsŠzAM6Fn˔V%V`!hjn 665ẁI%dעMBRaXIUϞ%ALP>DmljT*N+z*M~A!Tֿ2GGJ*ʇrz|\o BUKXM\&$ 1jcs d(#"IBXJN܄7\ WkeY ̦+等 YQ'7|\& ALxn䴦T !6=#ʎYcB5'SP 9¶JFMñŭ3F޽%qPܚ)+ j1==Nݧ##===QY{{;TUx\rb!YUUsJ[-|gѳ!fdLTs`.`̐(Ь` p+@2;\ccd(|b&N2\fA=P&aBG^L#g?ly Xd >6QH4¥2Q#h_$yX@llwbg'Y5UUusR sttuEBo^cc} cϗBP{L@d쬖E2S4 1A+Anmtb oV"U0Ju籰Vxem%,p M3X@f\ mc4S>`$%ً=3x/dYʄ>a\1l8*T<37cbDD-lp*bM8i`F!ПICd`l`d# 2s c'Fdۈ a8\cU% }L @ٍp؃0m t~@fÜa 3 * q lM̯ .X;0X1$b1~d ?] G`4Gp@8A3Y" 4 2L0PBrIހ 0\ ʲbXvC8u$4$ M pH'p"2ԟK]-fR3Ygs9E2Ox`Ҿ~Rtkj Η[%؟ Ed Gv/`&6 A?,yg!osHi=f jԄ\@*AG?*Š Aʗ[}gsy$Q)9H[Vfh`nTojݞLFIH}㹎avy}:Q-oW f^ojŊP"h7Y6w~yˑ'4PB0̀eȱTp2US,=a4(;/ߟ7zj j?{rw^k#iF[=~<; FZީ`U t 'y ?`W !f@+г@X ]'UGa\ #!F[ϽBدKΰczmD]O7ˊ,$2AІꕚ`rH*uKUr3Iouoo׸? jD0Sylǟ%5Mx~`!t)hlG{F>eq/K:ʕZf_ !Tu DXQKU0Fa~U0Vd\i hpu&#7SծϞigTy\ly\R0&"#Xqdl6ilVXn$~~hBVOF{0#\`$v+ UM'rMB@gƭUm\^\QYr٩/) En4_7FFԍa"Io/&V;;lmf!H: "BU!k"6SB|!OTl, Ւ3Lgg'!diiixxV[)zcccllP(B-әGGGΞ=vX*r8~ٳP!4\Hؘc{[nZ(А"I& GGZw\}q.---OS{{]GD)H0(﫭F}54R0(mnT*NUUKٳg܄'`!C՚bhPi|L*^0T(4vwwϞ=+Բ-F!$II kV~?!$Ra؟s(!=5p@lr4 04!>~0dJR ===W\ⶋ`9qήUd:> u!ۛ<@';dX%̝lEt:(PgϞB1/^GGGH$nll$F +J>r.;nmm yΜ9S.;;;?~<55Ev3BlNMM=|PUUF JP*noVFf~xe2ÁQ^'2q88=Id-²t4doOdRQMRd2z.r"tvvyn+Iኢ(;;;r`rrrD"Q#H\.Jltp8<00N%FE;w`ww7H|p8L}ն>V bXX,VV:!tr9EQ!FcttҼ?88j<F%h;嚎33F9wl ,oVXd>l"yI5-ce||< aϜ9($I===~t]w8OMO;vw^%Nt"Y^t| *i$d{<j)K\;;^XiP`PJ8U~ !k _W7Nfg+FZƜNBJB|x(`&&&Q(Frr<υHK,Jl}fCa&ʍM0mOdFfF©nZ=zV_|߫\jXP򯷯PEGtJFQV#'li/+#SO61{-3fɶ'fѕ?d Ykx"N$>-2!KuF/hGݗdi |gMSᬌdPQ&[ !H Azl,pw%;xk[QTH|`ڢ>}8Uz*UqVA eÑZ _FA}4qa@CFL@X[D].7kV";TPg^(4TU}wWWW1hͮ?S~ t4??rn߾ B7o\]]u\}JzwܩVO>CG ʲ1,wi4 lo!bTmg 0bbepnnBF/:UM ] N`UXT֍RIBv#VVVK4Hd@5NB^0B. )e zŅ̧y0 6ni>A=f؀`BsB B#ӟ~488hh[z4___ۣ$˗/{]]]}}}+++$ ~SSStocc!Y'&&^fflvhh?ַu޽ahw-.V] : 62r8ILNz hoydĝNfgJ*rPHpN2Ázzzz}{ϟSUR,..6 ñ6==]* /@4_timm-HF"ZF7^o8~E"p8|Eg27|g?t6Z-AzYUU1Ɓ@@W^y%['t ۓBg622R*WWW_{~wO?a}]wppp07633sx<DRǏ{{{ekBGqR懖>2!2We~2_|83n? !3L4} ƸRZ-o|d{޹F}^;/>}͛t\.B~t:]T4M[__7R >t~A rIѨ2>n6Ȉ;VWVGG͎O*aOi J7n^IQp-,TQtJZ">|'$yx𠣣X,\`0믧RW_}uppT*&x<~Y *ЍDPi;!4==zkZWWM&PӧOkםNٳg=C!twwe(ofXbGGGi!ٳٳgKbvOMצں?d2' 02X6Ԣ#>rhzwX]]|7R) ʲ2erZV.V###|v7VDrԔRZ-EQdYVp8E"lYt< /<|XP>yRE2$ZՃA^uݘV* .ԥF(t?'BAsz]w$BHA^ĪJMi$TZ-?.] ΩJF4ucv1ƺTD^n> `MT,i LTnj!ƣdF/Wh4JҺ\.EQ^>,4pi-ׄp/Ll5R ,S fYTx<\,7 ǃH| WEzzG*pXuUU%Ir\JQ-Baws#C{1Sq",½dQX±A_'qn)XB ^o-fH4xa"6gXܳ%|̴vQHA˥\^*ǡ>[<>>>D"|> -,,?l fgg3L(J&X  NMM6Mt: BOOO:<ϥKIBVӗa%c1IQ I:ˆMC4AI2*Y_ojl`bN;:;[[[ކBhg=8X[]JZ랞fnJxSPHUr/ issKi*b>}zViMO@ŋ-TthabUIoś\,E)JxQUUUUϷtzT*gccc>OeJ l14ob)(UDcd'1s21!vvѣŁqG"><<, t TUBꫯ;\.ɓ|;kooJ4~iLRtuu333r9]tJbr&wu>r@@*uYF^.LFsەIXN;*)v:BQHB߯Bj__Te!400L&{O>dppP(4t:H$www/^ά@3MSXv_ӧb[.|LWWBc} @ƙp8Y__ؐ$BJ\. 6\YY!$IE9>>P.z02>{EÄl6KK$tehh^jNu'FuF)G/oi% yBzib;l,-Za1f^*`0AJ𰷷 SL&C5$@[#j&*@cժh/{m;1Q%Ö=W8 (P'qAZu:ќ"tv2C:99)$SN S)7HY`˹N2ogg-~xeb+42C%0Ge0MhEDPC!B~J-r I:aq;O\c+,!vG(T$_߄F`7y? 1ZVe> @dc)"$mob]E"01^;:0p㉠cT*;ܤ\.CbjTUϋ rp(L6Ri|ZU*55m5::jXZʑ;zDau;;j۟ T*ӡAPPVaJ8$zBS ;; +Kt[bli+v775H9N 0uEe&N\fu#h]ZZRzQ,t^_ =|PӴw}^R@ ;οzG}f?DǏ?{,L>z(Ly!DOJD QioXkzH2{gP muxwud<^±Ō,䙮bocᇛ_O&+NBL޼9{޽fIܹsgyy?|2Bh+J~{{{{ggÇx LV*G}l6Ǎ7?~h4o6 6H$GAj5E̬ ߸qV{9L&#IO~]{zz~ӟnll\.??rյT,Z6ݣ BzY[nፍt:}= ZJzs3]ܹ3>>~mBiQk׮hV[NgvhbXT*o'|255E߭өNy:eYju` Gn޼[^^Otk{{7ϙ~_looj.~ibbbyyymmMUt:x^z饷~{R|>_y񾾾D"ۻi$!7g[VߟK$έV._Lx;*;sS\nhhΝ;VҥKj7HVUzt^`ӧX,vƍd2K/ݹsgggܹs xc<33CyA2xq۴rtB9aQg>pqdό"F!c3Pt1(bP ###>obb"|;ߡeEQ% z^I=zD$FH$rk~񩩩z^V{5!*Zl6_~xx/SIX,==By<@MaAᐇC^W{{nrx؞ls` o4FC|Wu24TZjZV[t޸1x=z499D˗'&&dYNR###gΜ ?zzzn?X*5E9>>BNSP(=zixp0Hzz޺uܹsd2ぁp8rJOOtttszII$2zWPh#px|~>BGr?X*QQzXܓ$Bxkڍ7.^/41(dV.'!TٹiyDAǀ,c$n 6RMb$.ܷ{P-eSNf5mUvx"uj93khj5o BMpM4(gl)IZPPfl~z^vC-X5B,舩ڟ8b](UU'PA&+ sҞ3e\. fx~n"qg 3x"'{8n?m6ߪyL!^oVs|Baff& ޺uhϥUIn߾MN:v8KKKM󁁁E׻_[[d2D"A_I&Tjsssgg~w}yi z].RI X3g:<>v8z.TRINN;j\,r:Bh~(գQ!Q1?l,'ObQǵwWVVjZ.K$drooommmttc\,:}ɓ't8~(޹sp8}>B?w:D"qttvk6;w>~8oݿvkI:::ݻWV1ܜO߿Hj܏oTu˵M[[[>`xxxyyYbh4W`E#{fs}}=P7( #P߿G@a2[[[\uM|@ ii`0ph~ 8w_0 BZ^A\Vvw٬PP|>\1FRȻ|^RI>8p9ܹZRLTT*:evgEJN\&N'.3m49ݑrtzff&xޱT*ET,--UL&?~Fwww+KKKr!s~> smllz|| UST*~GGG__~"#zVǷ!Y *r9]i%Bhoo^BTUJP(DY-Z-H z٤_p:R !Dgq?6-KR޼yҹg g9!::z kkkX,LR2 B54D"GGG2\.^wwbJ=ioɕU==[YYh{םwNT4 %Q|n-R^д&*?RVBN*<T>_-'j a'$# 9P*h`2H˿ŲYŏ@c` Qօ :7!4s(=:j"( #sHکG޳ҝ;Vf0L'k.,HU}v\C9?l|^ODG'6ѨdNTRQ0=[d9NòL(HcfqqtaanvAZ`]Asw6t6~.b6QW'!kMӸdeEd!l`4`-F+NA>1*\kqb&P.NE?E) Ҝ#w0$ gC(F&"A(Bܑ`Zٳb)c0iѣGdXբOD7^w||wV*'O8p8|ttTT իX,v/..v,CH$PJa,|q&r^ Bk-&un J&+FsHtPhi4 QJ1VkK1 H:~Cf*r쬶ݻݮ2''ENGJZaa+++O<(y ׯ)ϟ#7ӧOfɫJ (٪lnmm!ǫW޽j?8X, *V$Aab^x9fQBNR@ٳg\nrroV`\Tj5TMV;>>(ZTw{%q~m>G8W#G ʘ替rw||LQԫWJe6=<}*vSN:0py`\BB_nT*6- A0JOKdyBB0:IQ#ɨp'lhL@RzA>Dnw0 ˡPE666vww777.KTz6:ikcc޽{wbbT* _W;;;&)LS:7jɜ9<. [-f&' zY6iD"~x::2 5zj /4:tss/ݻw20r7y/fz*aAj5˲(eُ?lrwxxH4څ m՚Jle硤~d2 Y١Fòa\|1:!hJ%8D"q}}ME1 cW);noP RI(pd䎚LVGL6`܌F.kyyyvvr|g4M QEQw8N<`6|C//--!)EQ<xÇ~H$BPYYYAG EK77J.fӹ\FHZISnl4MkL&gVX25ū=/ӦөhT**<̓^lO~FC۷MRs׍Zѣe2 @ \._>liid2fRkjukk@=}'_,JӴ^gRdޕu)j@bx̹:?l;-J#Kz!v)->W&{+0iEQ?$+Eq)S9<{ewwwrr󽟌ϟCK}ٿ/4_GK/4YG&rH ÓL zmΕe3㩧] L)x|wST[i: $݋8'THx8 N_@IpXt"AV1}#GH)ձߙ$I;y̫ 𚇳 % z QI0wDި`/wiC?!HԤp+;dm i$D$ N}M2Hn3Mi Hg0uGФ;D4hĞ4vH|#JɀҞ q(e ǐd-&? 7Q(p#iHf hp, @(F#1$&@28lW`r3f uH6Akvb2H eN9DHht]\\— N*"[JȁT&P_2Lf~k cR# SrW$'&R 4Mv(ĉn6Gd[}WGrdx%l] w0/3vGlb FIQPrʅBᏏv?}z@ƣia j Q[NݍFӇ1 ȶZnNERy YFӍF+0 ^=;ZX(vsS6|5;;vɫYg^}w7nwNCLpvt_E;w޾FӅB5kX&w:B,Ḏf OM9^>K&s(oh4ժF۷d>_xl4Vk]͆sMh Z^pZMTX)tkc*RjCzBAe2rnL@<5Ѩzi郃d2W(NO/+?.-͔J̛7zhZTF&RDJE<~kbNB!Bn,#'H|wbPAU }%n*P6H%@,jm"uU#g';iHjsZ IӅmo"+ rixE%#>pE~a*"ȹ\V-䤕aZ~d2(2nw *Iw5UMO;YU7u:-Mj5wUJiu:Z:9Н^)l\XV6Yjs ɉ }0VXy޼NNZzmvV+ffV(BAneBR&YZ9=|6lrv;Ͳ-դV+ jm-psSXRqrכ6bvzm6^h4tZܙB06Wfg]f{ii&Vf!,/X\6QBufhp fe[fqbBqJrYN MN 2LSt$ܜGRv:]^{P*jJR RN͛sffh\,j6I[縎N/,Ll(lj4&X(f2;ཅT\OBX@<wUVHa_>2..罷K_\(P:Q=X}TQyԟ!JRIGOqX]h40mDRvy}}Śxdk}}>D&uqu F߿rYk5f3U*cX8|kU*%@Uj,M) +&Anw8h$Z5 C_]~_*\eu՟WN 0@2G:034$0AD4GZ\Bu$M9Z#mOQRAʎiʪc;=Kx/ 1lRV0 #I'qU 'jJьbRu~TJь^eV4nׁJd2qO?]ߏκ4U*2Vܜ7TEBdl6Y;|a77X-4m4M>Z(@Ԅ}>l(`A։9O4Tz]__XXQ#33n-͔Ju$-3L3M3L+|^m4R!t~_2!&JET*S1;xIDF[l+͐pQ V\%G aѵHrmyd'1{;d+RET"$#t S%7)d]NNL{VPO]]u$I޽yY l6y)vyZYBM A\.WA޽@m4+榤өՆJbnw?l\fwvg|>n+*;;;yy* FtҢ>( zT.3\Wlߟrl&בUff&u:M 6Z' wٲNq:-f~rҊ>3r8hĄ>)xif^QUd^g(i:Vr8h1No'E<l@Hi {aD1+HyP> endobj 149 0 obj << /Type /Action /S /URI /URI (http://www.megx.net) >> endobj 150 0 obj << /Type /Annot /Subtype /Link /A 151 0 R /Border [0 0 0] /H /I /Rect [ 413.6467 632.5268 429.9097 642.4474 ] >> endobj 151 0 obj << /Type /Action >> endobj 152 0 obj << /Type /Annot /Subtype /Link /A 153 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 101.4555 260.2500 320.4555 ] >> endobj 153 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/09/soivoseltamivir.png) >> endobj 154 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 292 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 300 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 613>> stream xA 0 =fy9뀟\cz~ endstream endobj 155 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 292 /SMask 154 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 300 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 97415>> stream xi%Q qNnwj_nuK-%dIwlm0ߘlc`00lÀrk_zVo7f{ }Gu8q"Dĉs2FDqM" [&](,1zaW{RH:(م(;vwy'GBvvwo=>9 ]ح(sfv0s9ݘY1lW," 1EP'ѻe'a;BMpN*Sᣨdٱ[:(ںYE-5CJ:%ڡuqMvSN{:EUB DvF !;Q;f4JVu7=UI׎[9=خX;A9zn<ݤvttp="0(⣣t_tJtBu ܨ?bЍnt0m!w=]I:u+gQ](׻M:zzzNX&#+~/x\!箮mV;~ SՆ[3+us"G>'T7 8zE7vsܝ La^R2;x7GzQtNg{г 0)m{W}n\O4L·Wv0m 粣.w:cu m݌D[7L`Oȝx `zqg']?/9Ss~;`ksyݿi:*//|aD^Y_lܕ;k_|㹟h=*cS|>kʧ'o94Cȷ^}y Z6+~跉HH9Oێpici znZ7M)TgW'O ?ouG~_z"}/oeH?c/ {FVrtpq cjmQG=vW(+^)drXKu/ ԫaWa9GqO㞏|x{~o?˦|?{pM~îh3~}?~.@6~v~/>#\zkަe|xW}ӏ/ʿkͧ-&$ǾVkXCoxo_7Ot~/~QW}g.=Pů̀o#y/>C~ow 0:{#[۬~1CNqQGG|{]ZObGgvMA{rѥ!LS}%S8 -'Ηdg)P_}ϛ;O=2iמ9l΋3c M"2-'҉ɷg?x>1m'LvlǕRFP[v` ϧ$|"$t{6wh@]~wc(N?4J9m/tpAR)nBGӳUiG_wu݂ކ}zuhgO%2(˅Ijn ^;,v-:G}JOڰ+~ww{s'N!zYxG _Y>=*n>ܑ#x˯}/,^_;ˋxͭ+륁\|st{x5OU]:ND<{i\vt/ģ/˵\ZHy-?೷g_{✦*c|fvi؀+Kfxx=_x7!ۮ_]*N?37xu5nw޴v~>{봢~~bp|z}wqޭ6ܳ.=]KҶJ[$'wyO9^v"NCaF#Dv-{NK*Ndtw9guNZS]xyIz.2zOCOvuz]bn򁝗 ݨz2u}zfqĀ*b 7OOxWGFz6h? i1zaG)8c38f;$駑h;$24i9 RUN;]Dnws=Fwmf'lhwlݻ I=ۓ]IJpk~wq;ARO9$q+=xMD|d+.xS/^](dz\"n|ӳ半>;Si 糋V_Y(' ·ʵSnj ]797_oZ?uWWpv.\۬4~8מy~OiXم⑩-]F?Ģ8}_yǦ|ov\%!.{:(1 =ͻ\DưϨ(`R=[DmeQ =G{UtnnʣSݚm;7\,_^X_]ʷ\Y*~ԹǞ F?6O/:ԹÅ~Kz>e3ֿcOԭ.\3VyRT[Xʩe>g곏=L2w_x|r01\Kō{~f o}!7U,վ.-gF{ő/>v1NĢS:S7.}:vK-vb~OQEPn {vGv=NSw{]dmw7ݰoētӁ1WޑG,mg hh԰42{nWʟ8\W{bzMr801K'r CD\v_6y=#D3$?wvg.gb ߜ3Můle_y|_\X٨;n8z`'C:;=^MwǗl+&:w~v߂d @3&|Iz]`H{.QJm^xN:Hpw;n_;u܅(d7pBtz [=Ӏ[E$cwRwd'^Gu>%.4q^/lIvvv7j)׮䓟mtϧ&DnF^iwK#y蝎 nvׯwD #lىbv:Et?6\^&fw:쀳Si:=cJ*T\&),ȶiy. 8807.j++x*8-.P,͑`DQ84Mz/'ؘɹl6\4T50 b~3T\8@5^DgWp1r_D;w#Da 7WBz$knƴJJ\sqD_Z;2MjHC^.W̙1 X\wʃqU %B̕-o OйmĽD\* NrciӬnvx,T17Nda\Xs;})A2u<)UƄ$tdJS @)Z}ߓ! WJ~yt  דo86הv/+T|rdxn+J2}h@;la()A"! H$4m3Tޥ3\HZWjYC '7~jb͹P:|*vp8yd!6<džc ~_V. a Q34ED"[ep-oyG7 _g{|CCCpڵ Dxhոw^vmrrr~~~bb J%5 EQReee%裏fyZ-ۖ?ocLU^ukvv`0u==i}߽cax܄}jU<_7׈j̑P|­CczNT8n6-C(r KiIdɎe)'5zt1D<8KL;9CPΐ <:Ojp1HRE T+sT/ q$uZDq0ypu ǣ-1t<" L l$7?ת/Η ,)7h{(K-Hr- mqlݸ7[iY(rƲGV.οBe+h7V hN=Ӄ_=Rٸ\i8s4GĦjȵQ,*M'ӢG2{'{¡B9kkkgΜRΦRC?bxbwsN D|ǯ^SOu]_ߟ,?sw|w.wϗ.]) Rijjjss3 !N81==tR XuJk o?g>j\zLQ'._ʩT 3 p誹R3 kUǜH\\^pw^+ 4] 9)Ε59GCQ|($5]4USO$'6,O*CBΰ/a0$MZ4Oj$9')R:|Zt-GT ԾM8_Ⱅc{כYtMQg:iǦH: nWV`<-۶ox:d` ,XEZ$ԁD"pѣ ٮL$0!= D嬐J5Sh&0ܳ3d0wfo0W"uTDYN<977799:S*cD"Lٶ=99Oi}}}[[[bÄZ%J$zkR7qD4Ms|||ffرcQȞ_zucc#۷G) ew}.\a .o+{=ܓ=Z.٬(7t??22+qTUuiii``S;T*y^6f遴$3t`b:>>I "'g|Z}t>#'snަ2-fbd:pdL#2`ܪ9^T}I6l/eh"" 2WT]b±] s+Œf?ފ=&QɴZ>2)$5ŭv9Kܶ/2=,IM-/,U]Rh2c,S8ͺ}Z98҉;~n8y2s#{ '|W|744TחGGG\r=|jr5&*c3kLBu2Xnͧ#IMC "Y(O1@MKꊡGMS_4kD'{7^\]]ǗJR^ؗtU}#gݺ`Zؐ_.OOb/٥ rtLWfʷc=tcCoHt맷ٌO 焂ō8Qɴ1l6tDRS豙bqIUH)MGa|0Iٞd\OrT8"zRjK׶*cik%EbnzmI 0)a(k{hyjfpf~f~sW49D*BTY36[(R<11_l 37Mf58,,R*X$(FC25"g]Յ&7fDZ߶'H:d 4KM'УE]BH(ۉ&-=yŔNZ pC/Z芜9|f ҖJ=dtݘl^Ww" @@vf/>KʷNotQs疪Rk[֍S+Wr+ GsCcZ˩3T/쭡بUʸ!*)IiW,J~x$ӔlR4@Ι ΄"c#$QJ\EX0!fb鈺5,P+V(+O% ê" gUSxfMglCdK[\Gq5MD Z4N]ܨ: [P*@I 2͚ng 138FٌlDq4M $덍K0!!CV+N2zRJ2T+m44Tnyrj KJ"0"Zy+( y I_jtPQd%IDD2nֵ%ϗn"[v{PM8jv,3ETJ zAtvÜ#u (Q٪;$rKOr ۗш!ޛ=S7@WkneS9y9xDtlpbUĴ~c`(>8yM7 q#GȥĭqtēRa{'JD*i-m6if C!gl!51FI]%2|JOou5)7f )#`@:mh*lnMh.(mgHA!RuP_S kH$Lו?Oo#($tU$?@eiMjk'Ur ӾzH ?׿*ŢiB! І:]StBS҆z۾t]O Gd(\Fv-}w"R@2'g` }gS0"6zT&DH յzs(ߖ1q{RJ"_ghhzO u%\oz˜'thl6%f' BJkMWSECeKHG'7B@Bjndօ I# g9 <+Fɷ\*uEȯWg(郞ڶ8D?m?mALcqVk;n-$8R2DW ;yyCEVpY@y(گcckwRPtt1D3>Qnx.u"DEY/$1@I 0逨+[a{j/>p$LJͤ\êL4 A˕/r'MLĄ/69" gLJr )U8‘!ZB#2d (kh#21M k ScYձ6jkcjѓsM;:Y-Y)5+xv"4s)4M;Ј7'!p&I<'J mXXX~[qXT+}}WHݾZYl?> Moz}&H0d4όJ)OL =i!6mϯi{$֪VRS_dؓZ =o/|<|r*qPy6hmm$AR 2 \L )붫pWʄ @)/0J3)}q#_#* Dd /[F<6E2^-m !W.^Yg@|㜙ɦӌ1u9e`,59'n`G# 3.@ZI7GɌgRJih^RWmONp!93T޴pԐu#4ݭQ lcV|! O.=}ɴcW76*/? VF`*maDB\X ,aN T֑;DD9g0DC@hmwd>%u=w郈TՓBXk BJ(H"cFc0\T9Q&{dA A+ذ,W5:gɕJ3)C۪āt,kџRRst1) !>w2_B"!`<4'olMeRR*2rbzإ~DaefۀaM ȴRJiBYi[9`R$ ^Ar1^o˰\ƒ0ks`G'3{WRliZ5;{V5 UUu]vm0[ A(1CLpuĀ ̟m^-+9`d R0S Wܾ2"2k)}ݷojjnnnxdxkk/zq}; R1DU%u#+dG 0xЕ3T<9$_L}'"Vm; !}SvO/f]!3FD7p3KT p,"/=}91߇w+?]<;f]>Oؿ'IT Z3ܲ6↹.=9mgݪdfvխPLi :kV.6UHf݉k,B&yRj SB҅|N2(΀pv1Z#I+e`/i$*5oͬTN\]o C4P|A&P@Ki7•?mhafgf׮QDFUKŔreI)eKg'JOquV7MNL1@IrnϯWd ߾Cqǝ\YY9ywIb_`;x SHjDZ[1 zB-L\K|Lhjۓx/LRfR?~ר`uܫ0 ^X.ͬKup'IdLUf֫`glXLUlOHJ ᓮrf{ MkC&#o "@JI?C@bGNml|޻^,xiY;FFF=_(! "ΘBCt8 2] E $IVk%&2$"}kv+[CՊ|yj0cݨ__2?a5ͭDߘ/@xoV{F }cŵS?hFhLB^Zt2JN/SpV۟9j.ݭgֿUޤe6_<7HDOB3?)#Jǵ[ r6eaܳE҆kfݩn{ (NQgדk\583|n2_L`f(6yH*`W8WtJ) I" | eԃ! +Lkh G4=Op/oo[ ׼0!*`\5Czmޠ2u+echj!O| 5ԟJ}aCAV9>z㞣'x6-볳s;TȋXj֛⩹ҍcٺ-l5MvoRƳy?m hnzB@^RRO` G!!\!.˳djZ)JW`Fcz F+H2@J 978omG$5PҞahiBpfW#Mnk+-VP{Y @X#v8KdL ̕i>ݹ_Jt*88=V>BR=}6_dx6|)xRplo1":{riaĤi;L$Vݑ҈#C Y"+vz8 i£6"!T\I/.X.+X3J0џet/ @xgUE=*}/F!kE$ArԈ|X?Te9d-PcJJ<֭7Lf3C-1w_sm t~Ea5=I#tB'zJҺY,WDzqlIg QC,O@BǘGAQԞz" ᑑʸ_@B %;PN@PWX:bZX5E 0 lkAcQPkl ^)Tw( Td^OZ-1/״J}^խ.6'dͭԬmHͅ '*͙^ar*$97Gbx3T2 4m.jJW)GH  6lWSp$ @0yf(ɖmbn-k{aW2m^-sHg q*P&f5C%4DV` .Xnr9rw^[WU=kNbaaI؆f( .Èq8ɠp0CS"G%B6W"ys 4tARD' yۆ} 4\o4zmq 4;֤PԨƝb *gF2g!mk97U= BKlZml7W L-Q_XXBʫkMhiZ;hk=ibщɅ^(;[MLF"1 TPD$)Y+ 31"%",%\dj_nTO廏kk 7Zo) ZZUW4 ҡ])B~}+k"qBeeO\qe%JBcS2h$^OO;LY !$%cb=SR1 SHOg H WJqWfJi \OLcAERH6-2ߜidIvvND=vm3!(ZLP&d6,٢6,my#  6(B"ġ9 5 {/y8q׬†Y7q9q0 6DE;g}*i5L"@&EQN/5'wH}|2yowPL.gZZC8l)6zFv w4댉cԗ+ôFov){ot`pasjF$kH,LHvti\EQ3a|4_[m)lomϼ MyN#-8B%T$ֹؖ9=̰KJVAB֖@n!3f.mQm\$f3Rv\)enJ=5.\ysZh4 ! 4]1 PqRcfEj5'c`$&XIF55Ewgw/+0<GW-"ΦGz}qiW pĘte9Ydw_˱ j* pL :hj2߅ۖ/C)Ђ酳8F9 &cٍ;+O~2(LO)F9YC@d?{kr[AW_aI9ؽGs?~|j- ǎcXێ9LpX82S$T Ù,a?8 .!ϾZQ69KYlxi&IiVӫ[ƙy$4'l򯐦҅Dl#Cn {ʪ E`,4O&Eێ/\ϦaHt b)j;;k4 Oj|xxڵ\I!!8 +HOR2tRƍZݱ@TJ8Vf۲'{kk$̤HsLKa۵1V*iM_&ljB8C3k'/m5Wk6fˑ̅X FR}t<~qx$"Dȿs0Jx5*xg+,J"Ip}鋝8 )se@Dm-uZ pmm]Tm)U;(9;qCNOOEP( [i㏿S|:{O~Ƌ0E{qia٦ ΅Tl1+@᪳ĕڮ^Xþ&8m?;5*VjYB `˳jiT^Djzl8kW Q[RG$RbeŔĀ%ܵt0i?ѪzhbJ+UskĿx2Yg7՚tF1d>smkԿLW^xvU=VA*i.5@Fq(NUm;#h7lдvy;u!91 b[0& TOico4Xb5T)řhj&gϽ|fGkN }]5~uqr FF2RD%uiGq`8" ɢ"H"L{:F95=l>d9L8Mb.Vx0}b#@^6=Pow>?[;2vU1` 4x-,+tdp0 jOmTW2@`J|U#?F`/W&~Jvb -ƈH*]3 IJkEZ4+jzFՆ0*՚[Fx "2LKɾ1kBū;-ɗ "@{W.\/ӫ//I`vs׻uэڥN?'i>DPjP||Ӿ΍dyn]RiV%D#McXAyr͒@:T|kzv@>23Ǔڜk jlnkvTApAZ") 6b76j{EDV8@۵p8Ӛƾs`fQd'iZ182*q8oLdOd r3b$ |'+Ԭͺ;+jUB+SZݖZ/"F9;9tRVV3F>0!CVV;x4è55.LfS.d6 psm!GXYB6gkN-iɕرM3u\jwH$Sk V!Ypj9é/?sH`Dz̪%M*MeN !硜ҏToAL$g;ih0∩`Li4-b rWa;vYK|S6dս`Jek8bאΤ@eիV<<1Glo4Fj©6VVwV=)IkkP ز|9Aۆ4ҚVk=jB"jV'v%sȢlf zh~vXnH STㅯs+H-Kfj* |u6@lԥױ7o޻zpwkc՗_m; EHI(ՠ 4" oo6xr Cp@(m4bPDTuzx6?r Ѭ瓐"m<g*vϵfrK]L'h6b`cMGh_OG٤QkLqթ*!UR)L. H%^|w|) aaE纮{GnޘΦՊWq+Hh\+mVɹ!WAtZ턩r ^ڔ,tc@dk;1XnT4 AkD0UFCap''+eDV񤒌1tʱ"w׆ɚaiceݚ8Jٸ{ J" G0d2+ӔazC„ EL ? a3B}L'nRF6͟sPs wgy[VXŸK.i}7{M^MXCK)Oh ߬[i!neG LzW,CMaBn%8p4[eb޴;nu*Atm\Qb{[uU#TǏ]׽~ڣǏ?7*t4L0^y۷׮Rk9(9t1WJ45F$̴nQk?oʯʿ?xקkժy^om}]kǓa718:x{m ~,bg_a`VRFDTF%B0D 㑔zZK`?Q{6Ostfy@I!ݻbx,R!`Tj<QO8L.-}+)kfrw+9 |sXInȀ1'R+@ E!# `\)CRѬ>@k֤`&-RZ1RQ,kh-yz͖km(=YTt2<Dz Y`6%U' X W^yl>tRk4(aCJY٪WH h{{[JVhmeqb1魧×[iQ5s[\r>x6:⥍c= .7̥n(>,"ީUn^ڋ/攬(R~~I1V>ZY5Өd{2]ʆК|%=}t +%)ED((2)QX`XGPg EȘ`0!%֊g[pf S%yE$!i PbJ+%57ĜjU++ukkrO gj7|6U/q$L2eFl1e`XozI:V7Rѩ$_? +ng&A$"T>T{,a˸wsM+˓F%HR)O \0'WT|=dղe,Ak8Ru0_,NgmEJc ۶4-C @(&ciõswSWnݟ(!5}J]C^675UVjxMU;/\2w I'!B (P$@lg]zn(ӡoW`cBñ=y ʥ@ơRclZ:g²MWhn4eōV۝ыR 0>ue N((z;0٦TZ0bP$scfq2@C00j!FBajU*~66~곟JBQVw-,;(@q==>7n\ăǻdl9&TTlKaʖP+-4 X0#? )jYE Ui 1 Y&[e )f(r~% aNL4gs8&B nBZȓ $\xBkIIlVeN˲^ڨ_Z*ERzѣOj g˳dv8_ڛ<:H:/hX`dFʔ).M`d@VRShm5@VKъɕdn_yjtbn4\V93X*Rl xp&菣?{2%&+;kZY@+ڮmrHj~V[퉚U;LkA ʛiҚ$nw<wZmm`HԫU Appz1$!)FI4QU;rs9&n]ݩ0{N7学m"RP%/)ѳ+RUTܧ.dIQNv*7'!bɞd13J*\ҽlla0s *j(L^\WD Q3f $R Ɓ4C</6;UBj{ʅ1xGFM#)ixgwk7\b % ] X%XyڥVKM4 blڒ1h7Yzp`wwݸqO&W/QQǚlCtEޣ= 'Ӌ*U2a-4݃Z1EF4KwNOm/ f[_ФwynZx炶\n\ljhWA)Nc DUjsNIKHHPRٝV' éԻ^sc[[5nsosy) `%Bd2Yzܽ{r||>8- "#+}2b:^Z5{{~|mAR?띙F if~|~x0>w>[Gh4DAKi޺rH&jzv>{jڰꮳxԖ(qFKhTw P*YTz!U=õj;/^/޸|qwWg&_Ӥ?:n/bY@[RU)+qeBB % E"sJA~:O.&so'9ܲ 8߰M3SVj}zjqΝ;QOG~VX^?[[ b_4-_37/@suvuWnno8 'A|o j?~{28'{ߏ*swDgWt}[Nplb1SP,W.Ej#) lVݖ,-lXz4#.ru!m4`gyr[IB ?N|SVhL!m[m,9]~O}jf.=ykˈ2? Cm1XKS'0p2vV+WeQc۴SCVTX,sC4mW??2 cuuӯ <;>o?k ߬~3nwVFRyhgx?=Om>ȓų#ֺsK .Rity|\dEo3ύ8w'>zm\|;+;{ .oNcj}?5X9ZF_r2Z,zfBH@fE`f>аmg?Bpdw.]<=7M{+isd^H8FD0bAW5J޹?U>" `iJi@ӧbiǦ~{wFσP>Ա"3YfI~6[Fٺz/\|nbޟD23c #֚hnqN' b^gQG%٬bRy^R٘ׯPwv.lo-8'QѪ80g㨓x>8c۲xǵ]4O{irh2L&Np8lnȯ59kxpִg4Tͪ.&W/oL7OޟJNe8ܕKnX^!L}S.K)C,JYJݪfq7cmJhT.vWvvֻzQ'ˑ[6eiB_ Dz S ! Ї3Sf(TI`Z" ّͪG'_tfC@Q/1R`E4ŵ"~|67/kZRtF|aџy4cgd ʵijb hJXE ~ɃG |w80B.PaR /U#9ͦpԪN$hC6Oy4 6VRr#X=XJ:!cpee^zǝ-P >a9=K7֭Ӄ aq}}E7v6[}aV+a, hSͿeO4E1S;WD,꟞^~0b!ce;70HZ)hR"LUiY&Vb\e lVcmVvG1 Ҟa9A@0mðpEZCD`dkk$B]QAY8oV>&rv^ܨI~7A2,+)bYoUO|cكɓ)ly+-0+UjiG~T  ?u*?Uū#bZw,w>@nJy9W^001Me,V+dr9*HIv]wH-u0,4ȴ~/b2L&Da~e4ڑھҸz|+[[[o=>~$ϓAn`LEP*j c  J4=yvο]tp>ygcs<"wfyRH>V@9@ ]o3lBr0L+CY-">朴fDZ8l9 ʕ=>n<nn_ۿW~??97?~pdE 9NT{i;fL(˞=|qcްQw}f~iQQqOOFϙ0ҪsaUpkTn؇JŶEeơ$"Emi0 *I)WJ2Z`6UDv2?< Rǎ0۫;ohNNO+^ms-f|2|aZ˭"M@h#d=۫W}}:CUB?O-d'7͗VŸ?o;Jjz~Xt}p $)?++?|睵5fifoZ hԪ~z^-xs+S?Mhڷn|ѕ"i(*NΦo=Oڵ/\vWw.׻giG|闞 @Ԭy陑V&r@RID8fbJ0+DJk lnoYZdO֝ۮfӹ?;8xio|cٳ5a l6X= p(ɶ?|Lˊhtmz])l6W]ױ7!!k#΅GDtoLERJk}{wpax؏=SQ3 &Պ۟?~:ho"-U/^~4 V?[s)CK"HLHMd_k4E9S(˨Vdr¥K0ʛwC&Y&: }vl 1j`ݞs@nAp! bLpX !b1|i,UVF9& MRȶevQ O˗YYmZO6ߧkEP:sKf˪EI ONNN=3 47|soo/Y+}ps?g/ԬvODH JPNh8MsS LJ֌2-Wh9)PlIRJ򹻁-?Õe:kӕnwO~u 5Ȑs5ѓ.(1(!EԦc) Җm)?<>88ggO>͵&˶y7U0V;Ùn?Iz `8f^8?&E8XIWa|> mDOfv$Z bE36jӓ [D`>BHK69wﮭjM+m9xL2l,.3L|4 •n(~iY|̑6!rόg~܏PE`;">byu[ʵD ȩ 8$σd̮R6z*UTZF615G*l WÂXa8ɞotlwݰN͖mZ';UF1$17o~wv/9Ȗ<=ETf]υ9Pqf(X[ibK'yH,><µww:Q˳ \˺yh2nz3΀OLh1!؇cDlzN۽w8 "̵2(KdC!k=}n)]31^ԣd a]K,BY?|ٳ%y'}}?w{э@DRVLq1p`%~s(a?8HF +n߾ٷ:燪saqno}Kei$.ffZ&0 ᳧@Vqrv^T\5<۴O DSfEZq]A"߽[Ww!|U pvr^%ĆQi^8٣jO9WeYVZ-iGIZZ폾L$ .ZEI3MQaQh|Z2z PXO޺Zn/a2/CAiPZ-6?P Ĝ7K d3 B⩚08kWn,UF%_T2٪g},Xr ~+/lcln~` GI٪td-NZ0rEGNn.˚/,:%5=d4?(xe NnwtDôVD@}c..^/zNDQrOO1B|qTz靛7 °V)Zm@g !f"~gNnݰX-Wç.;50EZNNZm~~d^1[!}맣gs΂vٺ9#Qqh(-e+rT$B۶8kʣF<̽c*Sݷed>8^1+^a,T,SSGQBP!$uS%ފ:F(|Ѿ]n`6g7BbT|Ra;5n0?pbz>^5qGtszL&NmͽgLÊc[g,-0㓮JziljFQ/4WM B2޽"]Eĭvgó^kFqh.$ixe? ` Ϟ޽}GH4+F~rqѩ d" Ƞ8oCG޽C4\W>:^̂"xm|GITadڰ6S* ZR's2-˴2^ amڎmϗ^Wr^f} 1@\{?htqnKʕ ,A*Sܹ| Lƈ!Kkj, l{ASbK% %A(CE,GrT,HbC"(&n3Fsư^ݾ};l֨ :*Uz!$33K#V^P8{6TE+/k %IW;e0IZVK~ʵbVvK%UȜ!u>赺J91ʝ2@N~x{{O?k4ȲkԻ֮:y7 qM]bU5+ΕV9YOxZ "Ce7yfw[+U8Nڭv!Vaprz[&jHŕ=ً|~u UZU|~k/7~N{+i G琦*[/Re2@t@\ /#MbY<A߁[ !R|#^XЦq(FBU_w1L!gJjl~HEӧOyB0iv%sV-GiGC?c&B卥#ewc97Ҏ̫nl8(o\md>ʐ2%-%_fvcbVΦ٨V$uJ%Ջ 1?\4M8ðh4[^W3_<9j6h6j aQۥ4j+;~@%._>ȗۏҿvgY>z=nݺJ7n|_a@ۉx0|fagbxqeg1I &fK !@{HzwĪ6گ? ӤxaHZ~.c]:5)Flh  D Jc]=%;s-wq-.:U'sӐfEYRq?aO0oVY2y>W,KBhxo>X; [A|0X]$ɒXJSO5ʩ K lKP++8r=2~#ۮ<{''Q:nTvmg47*|*^j4̵^Kv9_!g# {V`/fx>x{f=0^w_Zlֿl*"A N?8F5 Nlō7=zdy狹l`Dl>]"jzle~~XUx:]mۜ!yatƏo@(;ఐeӨFRR?/{|e-Y5'}W)7~38*Q@;R8YDqU&ɥpZ~!@@Z,c|"WHiJgΦkX+߾-ONK?.9ٲ{k#J3HHŲ7gXqMD\x 4rJȶH$#1쌧JN&Yodc q(Jh:Wa b0\^Rd[vO<}7L3 CTZ{^^+h\eDË VJ[/H=TA&.8kgY;;i.T2D~nhe2==*"LSe´4*^z0RlrΏVգǏ7y^\%I6cK% 4)'d "Z ת is@ّDKƣW]~mGQ* *鎢&AI$ "j Xc-]ܩ8o\m~r2OShW;UFh6.:ןD_LDd{[pdٳڣvU*I@5U86|$9QP$phƇyj^'I2;{ppڶgQcn|NkqO@ .>6[GZ#"hpdQʀeny>X\jNt`Q":V3/(]0"1ĉ9_l,R6|l5 14$(;xy0N > C^oI͔QD2"hD!vr=ՠ"І!r(yFm?}pTBeРNJ!Q(R& sadzqMNsUb /3| 3?L/EZ),60.wtu߸)pjX%[? 0 XDs,2R2"Ew.S2,uːUB%RѢpRW\_໯wyzsWSIu_V`` BrO/‚@3=u9I&HyŢbl}8e7: I|hz@N@y$MRrl%@,y,PI1"D<#*T8IaȀ8{^q\LϞ}Um;]xrpm .?'m;zVq e@$eHnA$%vt6cbaYH_LD.HLw27Ñwo٤ kճiCho@@?U^Jl""M/oݺzx-x~X|H)Ry%d>HQΗ:YxxWXz Ai +dyu>`ޫB˚S8l,-mT%4u-]0Dtc?ׯ&"X(a&齽|T6i 3Fٹ}6Bz=Hd>߹z] IW'$ }$͓ ^ Q\yB $"giK`zWW'st#JPfˉ gh)XЩvJ4*7(6E b29|^&H$MLf" !"w`WwfY\M$|; 6pg{g8qlөNj:eZ&y^:Yqe%BM6yRz0H[1FD~N[a k!asAjX㵻p[+N+w~-WLd0m3Dg)$. k$ǁrPtSOGnïˆ2D)[26A59EujHn]M,.Ɩ"tnnHL`(eҒZEv3%SZR*Ygq|i0lV+4 T?Ͻ!C~] 똄.n/O r+kӐMWw+jjT8&q=/i6uMWvww(>j!8" }3 &"y-;Vej׊dG)cU]tS_%%e: >=Y|~&gӵI$E$%Dޠܫ^~LU+u" ٦X8_Ŷ?zͲ'IjW8TSdOelHHKyͫsIPc E K.[j垀$}#Nj2:VBMwt@E۪d I",t!?|mߍWn ڭ߭E({`WA2X&V>΃<L% &OE6"e>9soe<ζ[|/Vp,w4X%{d438IL/Z}28/;Xyv0Y Hp@ũm3"4Nc+{]ve8&|<~#Jf ,X[5I *`  2T&‹ϟgUs6? !I1lVڵVͽX?*J<;$NCE _H5LByBZ)9ҜeKKunr*)# 'P(b5)*Vcs8qveX`d5ORSl眽z #OVaB Rj,3i_9Ȑc86O>E^R{ if+Nώ>U[V-{O5|`[|X-W^,ٳg/Y"!f YiMN{_IJµsǏ߻5b8ߵ͗7?T$rE+̭:`)w/F뭪{6_Q5V~,5^H qZߪe Jl"xt:2WCD'_s0\B=\(^~oPɵe1\ Li@ "مEB%P2V4}zi`ڨkڨ*5֝^PQ Sb&]J" \ǽ=>_~f}&o??sx2Tr^y_;O\ibFɎTdo6 pPbgӞf4۷yŪDNo}zbdkTj\N{ gncQղt:((cժ 0:/84[ur2Ur@rm9;I_^l`^7~ps8ѯwV˸/ȷoF) 4ƋPdY$k+c?K,=* ~]Z`sV.(2 EDm`hh/[OVX!(PQ;wn~=&m^" UHOx*E(K!Jep^dߴo inʁO>.%Xx+׷ Ro0J:Lvww_xA{{{Je\Kx1ލp/Βx~6FDik܋ZOF/T`+d&2яrW/[o΃2*T1$ˀYY-ar@@V*/RVS9 AVAf!LrwE.J3(7*@ӺɓB҅TSQL L~ |{Q[uZͷ^{-3Doe{ V3_]WzQh3Q.CYs]e.b5J9d""z<v hج7cKzF˰reH Һ6ONƷDk;DSvnAd,B8 `f!IYο=PJ hiVNdRATM/LhŃw%N,,a!E*wkwwj||6cu$|U$- fH$ "'yZfTqY u+R|Qx?~rjJl!}A|c7euu4ܬ]d7 ftZȤxT*NNz=亮چ B$QhXl1K|pkweV []{_>F%ljIނŅ5P) z|~<_μ01 m/FYEJ Nqeibũq&k4dȑGilp^.4 4Qg4kqZ08T\ID@ -@]5f^4",k7"~Au9R ;| ΒTn5sQqCiUϣ"\eauK(!N\؃87G_QHŁԌj,4*;Y[I2 DJM-v>`0q{Z-՚aeGO׶gij랝l{"۲fyն_+l(wUB0Ӧ]c{yNB$Yp1GOYyƍ.GP/[v+r|j50bEee@T8e,ë{W`-4Nj8UT_<.7sI9PHBJeWvôZae)}ߺnadؿ}v^r3f! 1Jf}AU(VXƕϤBHl%>Yx~1w`\>xxXroJ.*<Óu. =K-E%TK/iI RV F4*P)f$M^rJc4/O$>x1pt/*B%Жm.+(2:غ_>G^dc;isVvH67܏Y=MONv,e`P*9R!l;>Y,oLfN:Uנf嫢4VJ49/~@Zcqz3L[)w N?z4? /x:; QjӇ$2xFdcXhZb]0øxxg͸KIJҭi& 7G+\E4joA @^؝rdo\)6++omuxq֨[v5 p*!MEձ MVQT2MSaVjiԶE`u!J RO!ZA=8ǯ^)jep6붛Ԉ41 +SAB´l|M"bU?iGz2|əfԫMnǠ6o>: Bѵd<2MR*caZZZ}%gksULOݝZbfñǯ:2p,# tL^oRF鈾>E@[ yT6J1Zt]]3 |DMd}#Dkn"9$' م.&խ9MMf~Y<۶$n5[J 41ئ'-,ˋ I iBT Zi&i*l=Xd QMUɅҌGEMRʼd1")}pU՘̦7aJ879v}';W-ì {p4O(/ / _A HoXV CTT~4[. /A& J:ѻ:`a(lj6i*D\t:?{E}:T*R$'+"X.~͹ޭ7 coooZqޕzMrejHxK#*M<Ўeνj6nSAQ"J6-o7Nž٭TlcGEXE+?^$ Yudbip*XsM?L(MRB@ۍŁ Yьd0088hZjuVGżV61$H0OlH+w%@m78fm~pS@@ 2CF܅Bf!;ǃ;걄\ (ERK,K)N@L_qS!Z''@~g^#HD00$ߨ\.W9szzh4.VIlE A.0b.b)@F=H`F888x 8LFqlQFm2T-i /|ْXFprks9ߡNK(& ӬzYGcmS<&eD-hT:!Q'((jnܹz>cnwr+[mGk:D 49PrtTS:Bfe4Z^җ.r(Xz59["/Nsqzǻk;xI8sĬOE$Q7?XH)PN kmD-""j93'픟\0U,Im^kwk7BP`soѿzl.x ,1$ 5V V))'8w8؝F 0ԏh WOPR ʥdl~UlfM6UmV7MjU*6FOwNAbV%$H$$0IpdL%Qlpa'Ilq1XꓣJ72_7l>r+%DW>;ac_x<{Gǵj%|a;i&cD 1^z<ң6M+.!Q+: h5]t{O?~ɓv+^6kԠr1:Nxu.xUת;w"XFG* w˽'K<֦aeSNQR2Ү\e62o_y+M!\mv=yv~|t!yQx5Z/,Ցנ)9%*Mյ;d1^z[aU:4*#)-ӟ߅܄CMITB=܂EE6V6dr jPjiJ4ө5, _w^/Ŋw[n\.N' v9M!78$IRsf1:L@H:4-r6ɦ5\9j)o/Z-GF׾uJ 亯޿X ZkOzfެWF`h6/6pga 姲cy%tey4hQWZ0ρ@ݨQ-[!Zq`$ݖ{ol A:2K02+TRѴ% b!T߼{Pb(xQB) Ni>HǜEՊN'ݹ*_E$@lԤ?xF1CC@FϞsי;[WLd%挗lH" Trm֡D"$E Gͯ@.J䊎PiKUyBm!c".àRON$`0*h|]suJ*CݑX.$U$]捌c998 z:HN[/ Nv2C@"L2Mo^k܇ә(̓ij\̹+]H;+%pJ~CHIR\k٭9R 5n 4S7ui%$&@VA$I~] DE1m4aμMO A*`ԑ&?,N`u>[}vej4}ׯOGVV/N;%q%yD-|JdȤ닜0P5噏Ca@91 v]ZIF͔d-a(eάL^Gqun]=bJݪSs-j$:%:,IJ+ZD|v j4-,h`WE*HMo8_fYtJ pz{^2Rx(9W|*)k IDFm1"0+R6 GFn&7u NLf؆&QpJiqdj"R?C}:6/pl㣟͍7? h4jZϟ?Vfs2|E:tuDהIB$$I[)3MoݰLk0xɵUf{Il&i-Gޛ[r%aUuэ` .I4tPd9BR8lVvmɔ Eh5IJht~߻[U?dFdbyKUnZQO(&).BG~ɧ%S5L&)hGg-Q T7gkڡ۞pavn8* GG 3?=l5? wB.yWcDI R_ȡ"`EHQK^y޽{z^ya&{xG*pg>}nBxK7f v@+:6ouθ'z",Vo^_xOPݵGn)LIsH W}}kJ1GvL&!_Ø(czV& ^؞_W>&د-O0f/؉=DE@J\{Gn8Y. T){6(}lҺ!(;c`+W~\\5{ZGlS1׸R.7u͑NTw~qqitΝn\HDL6?=h^Ta$0|0 W`npY͌&F位l._X f:M*Y+!QTpenl? YWWV;h$x/n4{a=4 RRye{a,M/։0P؊(2,HTdw{.#~BC|ҥK.{vvva _}_|qggj/'$_\u;z.'f|3H+: %!- 6V (Ns$IX)>`qF{/6pR5( ]qkljvbIC{<;/o]sg= /qCj㥹A8l[A෺le _s0[ !,! :)QNN jv+Y;=G A0! tyb' “*g(N.-X!a[q x{]"u 8' 8("m gPS6G\k jC4b6w…^|qwf(ʥrrzf¹f>"K(~6l:H~֗h`M\HwR0L':0Lsw3KDclىMkB6)t̒Au9(R>ȱ'܉\[>uvZZZ\,K@ F z~Hq(嘇[IYjBD9WS}~X _z/q0n(LpEB_;QXΜTC'Stur@ lNmUJ1+Qݐ񺈌%t{#"cBr_3>ڜ2aɩ AQ.;JП (OM~`0U*泸PCO@Q\jҔ$=T u+iL)`.Ǎh1? @H6BHz?(y~Rf?Z}: Lq:k]dT9DIe%8U3J%NuU !u3\X,eY6B r|`azfD9" !ϗP뭣{+w7SDž|n{ZGְIv.5)j~7b?(䲐t;;|n;f2A&a&nwű?G}%12.YY.]y&ͣK+<*F0,dc)F}[w׎;Ȧl.%Vgئ6י<ݚԠ' }^nbz3O$clqeŸ[%(8\DQy^691ꍽͣs:49E9a'h(]zd$3q¬;ߕ(l%BW:*\;߽K{MdgOs[ɩR;leBb"г@o~s(@c0^FÉ*0bj" r&Oqfq]fE j?ԣw6lX U Ky- U6WmM>-DjJ t!2~HtAvj~.Mμ~G*_VVNw)d/<:[{3w>, :w.?y2ABZxi|֯e{n g `cZw){n(E%+qBw?QkwWgA-E )X]v#&*eJ5D~y A ZZQ!i̢{;=_4FF3RF"ޢp+Ě"$R-*j3Y% 4w R#N96K@GT!n~;D|g=o+[KSL4DĘZSWG5JL3<ӏ9GȿbD?|Ƀfeh喠-4 'D%"msCB1IsO,/"F;䲙[{\& ˜n;)>(ocs.Z64raE DR26f{~JN@G#}9)p CH,Bj7E2iu$^jE[1rwx5svVP ?ب=}jjn5:˕EqG |.! dv\N J1LyU<K%SQ[M0 \H|s_F'l֪d4IZ 99[4B@k8QE?nՓU"yR=q40乹!!:s)S*qs@bYqӡUᣜT$">DjG^<f VHkjrI|:q &ZX|WSq\i$k/&DB Divvv8yMs`tf'3XGEA8;i#[&)ȑx;q3^]{R&Snޣ\#baF9?=JRݮכ+++3sqvUs"L}(̀h&Pī.qGsv?^E6?|RڝBi J3hnopq<vT N^JDHVf94ӥz2NDbs[bAma=60u~bFFS)gf5WMƎ@&@c)es^'|*ͳjUiK7,er5`#ZG2v%{&JfQ6 !5`KqW =oI&qĨxJǐcA.M$Lpr}\9ͼ~}dXVw3g^^33=j m(I- (6wAYlW(C*W6 =s-0Q\J\e贳OT 8]n:!N:la18lxRI)l^H؄yA (U:m$`l$ 6hF^*vgH ƅI (jW3/n` >$cP8G.]`XWZ~ {RNBP N~\ا0Z s+3NQ7Er[?E!`ЊL ڞ)ht+;D ɉm@NuD19H)QC8*9 ~LƴSw**,hξHLrv҇{H-U!e:DN2E 4t5kD$ϡJ;AN˨ϸvӘҕ5rkyjjlK q1PWk!op'c6'OLMh~Qx5ïT7V Lc?Iaq@RzTßLC*2n7"^#cSj@ BFtP ʷڱcMz1h/S::J,dd9Us3-CJbH*W׹H1.@1Qh`G)?r&0_ݪn&d \dkJ6CWJ 7k_Z 5 E<*i4I, ${Tq`W0,'6MNt%3]bpѽyE1#z=ӂMVc'ait٢&gD(qC ^R&0<"]0jY ̶W=@G5=(tF+_ ϵ!JFHD? Be5l |@IR!@O/w/>FDv[lb*lz7 'DK@̫?N&*ճ!ѮP4SIStlXS$'/ ṌrXfJ9yCD̓@h(E]ڡhP?'rfX;SwЬJX mh,d&66.2ǜ^qZ\+ q&ARjFv[ո@".sEps;qpQ~i%(UQbq7LVg8{pش,zgM236;w.3#>1l|ēsoo: l'!LwaxH_?.gL7(6 l@T>-BSj ݠhd\mpWM= ?VНTALZ#= 3 q0ʒN&,kF-f=A4{lrW;P㭣F!@ Ul|c%ʣ-ΐ1!).iIq@l4N,ZxIjqĺlef}2JG#A(,Wi0%UVw`NWVTw `J#OGĖ10z~o`HƯJmɐH22C1IhUITGvd.mC{$K 8%L19&C%Q"}֌<(Dw~K@"S"CɒWxZ!D0*M62:%hdm5*Vb}$feyUKLd̺&ўr9زHR4f#ZG$K;s((Lc}@1/.6kF1ak0nL*+"sHRg1đ.ZX )}U]JQ5"1RIN}ZcheU^WJ0$aB6n, ?`YR iO%{Bq0Q.ASb^=FevD˟nDSy5 35wj!J>i0#mTp}I(Q$t@xwK,vT 3c#AK Ǟ7'GT[KNrAD۟cWЉp1pY[MPtMzADBa-dIfv+ ͙B#T H<^Z4C0Li+;Ċ,oV FHtQ 2@xe>yJeKa`iRDz\]]#L&f3 t@JĹ FgXN$c PNoxic a:I_ ?Y8'g'xh=ac S8X .3Ċg1d2t ⶐSzӒ:"I(BR1D!SVQ{I>*3G cbWE K3uC@RZ*e=j#"ElUx;6-Қj.ЭY@d+]-~ŶVD)!]׸Zgo#ռ{ Lh? C#,M@ЕhUM9p> X -$GLH-Q@YUKe8#G!T*Lrn .k~Fi-31N,ޠ鷛懃n8A&p Bus3d;ލ+o/<{s21qݜ]\IoתӉjb[tK;Xc1F|2+D ЀC;afHDA|G D}_6WsmX 9%8̓.ۋڒG PtnL:K`_cL6gMdr沪'ΉCa&b*qb`d}ZSSTBKNP"`^B&Xӏ;sȻi'!Jy*ٚ=<^<ϋPT4ӇoOÉUjB1vr_.v;Cֵ\xև+es4U[UC6A{z>_"- a4sVemsڹT acɸ,dLNعk ƫtݤ~YN_{duacC5*e2~0Zy7q3X8$O`z"1;.䞌 1D97/t</GUF M¸azg&Kt *Ӌ1[P*dq~&Ug\cY%O!b촚S9fW`9{H!f'˜/h |W^=|"tFve}rb8ygoSWo,?qhNXlת/$.\ߺ;^'tGɚ0Ok5zǞ07m1yڇ*7Ej%Y "fY-),,I \)Hjٌ ojZGn]f^5k7d3&I8g9`d^y2 rP9 qV!İe몬UbݿO|{幥ӭ҉3{[{[bygsj֏Nֵ޻ǟik8n'\wRur( ^8 Vx[gzwQLKnGQujNL4v1 a8d(=K3DD1629#+aM B߆4ZY(!o9;s|.Ns?d?^;Kwk޵/x|SR'/V'̓`0tn6Gd3p{kýl6??;ѕ凞Jo~&%{`榸g'2cajEޓ@c+?2O!V4N'Gl3-b(b։j-fja xqhs[${D  8cf }k|qq+[wLJ7;3W?^]\=r%cDdsv3(ZT9ۺ{~m5o^}7_(ysĹ˯~wԋ~( nvv}M:f{o|gnEp֦f=v߆hC Q+㠍Щ!Ny7nX8?vܲ׫? #oIJݣr\^LLH~N{jvaeifda*7g|~xvy 03N?vP=RILf=0`@)"-| !Dy8nۤyG@n^SCJ]0]#\RY~ i!FE%dR9 MՌІJHEц).IҨƈ;&uTgV{NmcS~Dn`Z6&C|WJ|Vl$I#RqJ.sȤQ[Rw'zE)WJL%z(q1G)Wj8?dbDQT{zt] b9CGtV9cCAo+-M MLC=u6&s L #cCKGM5r{ORib##27咣8lq#>Ғ#%LSĢg8cGđ8ydǢ`(GSر:9OLq󎠙NXGAI Qz8JQS7(KH+\1&Yr\w SI]h9{SSF$7GM]#[{z:Ӌ_~բG&=]!eO}m=7]<"DCe;Sv&&YcejYdgY5v9nh-|y%?1=T%d!!*Z 8ڭ,"L0_rYcwx,Le:_'8DqL 7a|gjIrY"ysDQ,QNSBiJ0E&(|@"="GjEP8t^yY7$\0P(Nn.Ng j)`ǿGz"V7\*_xzrQ-DQ FT/0 `iJ ^% 6s1U 6<M*NkZJg_v7Zgw%g L~m8Nznlھ xB{488z$S|T#rH`dHܶPh)5hb84KDl돟)Ld/}XۇvCΞXï]E1e|~3g .ÿwk?y}>y/?zws~'W]'~Ců[ʏW7zxy6W-o\wgt@;S~VG[wG~KNW3m~3_d{lJxcf](i[5d{_Z(gU?SvGS+??ʽF;a}omOU2onNv7zGO߾Ѹk~틟yzݛ YY%r!;>,ogk[ݫwZ{ǃO];cW,vf'_<k$"׽GO }̅Yhv{~|.}Xb/ "YSKv z{"&J ,]O Bgۑ$B5V/@:at??6.ѿ0ssl[)gֶ:o_o矞>\ǫo^> &A·ݵGO?y ?{^FޭaX{q`Nows ׎?瞞nuKs_X|[;A&p?1 juï|{ԉJkv'<69^䅘jiBԺ=-x3*(_ueD8l _~{'UFi_L# [?K27g 4/-~k~ձ^FG>LO V8Yd%SkB LEqlb9sBez Y(dN>/ {;7\q.p].ޯ_>xF'fr@[%LB%)KOM^Q*q+hiH0@r!hv"NUg.煥$|fIIڟ'[bvDYt[r*klkF0Jg+r+5߃avrџ( pm+?\J5 /{~_o7-G>n$Ҹq.ݺf͝]bwv4г3㿸7W֚fJ85#׶e&pqbn,BWR3%Ks3_{&=|~-V7yB71]>~ٿOמt⃵œ%0v/zl065ᾇżک_xfj1aW77; Sϔo^\d9Gr!(}o~VoVa9D^M$׾o7~#J߻# -Q W ˮDtOw"SO 6lHo`%F{{W77_`Ib^Սgs d9{ԟ"Ѡ_G'秲Atf8 F'f`_o ٌ~<3I?V 9bvӹZO/9>?])4;L5;GJf6hwDnmv=Jy~*vz'v8k|> rs_βI؊ImCʸ RCF8s+Lэm:Hꢧcg[g$t8'5iʠ :ΐHFa]aFL4b>|a *,>c?2/:c#oFB@uMЪhǢp8`UtYr-}P8fCfHhZIfx EZ$œaJR>iȸl9뻭SbWK/=y˗??W}߿kғo}_KK O1м;Q`%[rjo(NXTU`KNbĩs;K$a:A; =؅?7a"kpzFok}[vz][}{k0_yV_}J7>zwQtHىH <T[uAQ:\<)n]ەCWK˞@!ctEnttFu;@54OQln.#6qCܛYrbU_====7 dHkx^o؎B6jA@ `f0gLwO_wᆱ*#_e}U݄Q1*2+ھZ` 6Ә;~f6 Zff \[;Dg4ebU1"!٤XYx4M~G`8yRA2N(jycYdPBcg`-Pv`.A?TbǬ8 X +S=N05?Y9ݰ@0AqJB8 Wd hh( pH!;̎~ZA/aڡL-e91MP&mAsEV Ǡ1@$&Hc`Ҁb-=۷ 1H~`s} +mX &%Ff, 2 lz)9LFNkPdXlxCDQ{Ù3*B#c'MJóg!Hu]BNt]C]1iBa4׃Bnͯ1uX!4-(@*d#a8Ц^;S+v+^)Vơ ) 00~&Lh )l(L`8j+f‡Y>c&$zlۇIo0s8i fjۏ"6FZ~$A!>,4VB %XD [_oԕ~BHT۸pa$'h42Bϯ&鑑@t:"NCc>x,X"A͚М0! q#Q,9Y Z +ڀ!r@kkP3iDۭ(`,LDF%9 X1 L : 1"Ҹ'$XS"6'@*L J<nj` nqN(IexA.x Tp&4hrvs  ιQء 5z Ylzb~(0uʤX~1K08>/Ao n*w3h enr&p F# ɕ &.,#D 1Α|]A&_H\"ZXaXA<L`갰c*n H[b 9|k-UBFm/@OB4(D`fDAi #ءN*:(pyɔ:43ŴYeX1(6!iJ%M& 'o/ܺL$鄠_r޽B0aLE Dob4k*"HSNؠN[М`0M{0 m ,,)abPIX4S Д#26Saڷ懞 L d (X>Lbz NM2 \d8(03HZĈdM $&@枡1w  M_1sga` H$$asGV"J\uf2FEQ_4lRZ:8&ѴIKǀ2;P`ˬbgqڼS @$8x%25AO0#25;:=S ]i]_ .ႁ%`A [л#Ed sO@&:/Yj, Po ,R"io/@"I GV+\4~"B}Mӓ|弢w.v!@|$p4Y  Q@ayS̩; R4HчQ†`H69Q Z Ѐib+Ԉ[kW6b-F^[Ui{SȗE>, [ ӈ0c>Ȃ$aE| M6r;EP O (nuƢ9 #*f}`DfKod``X\  Z H0DC pSt0Xc~ `,kEL5?/h!t(!ů~ݻWNd2h4;:?o~:B\ŎR%wt762!D?}66~υ cۇxc\΍Z( @P5 Z,ICB"CC &/YĸF}"Rr:Ǐ'kkk{Z"j@(Vǟ){eYY]܅B!25544m8!40 `6:1&kjU06嚪A,])ƦLVTuL9x cca]`߭ó i12@<rGʮ opED¥6f-`? /_o0!$᠓pzD!9a s#L_Pt-Q01`XS  t B۔XB`ɚlJ(4^xn2/;Fs 2omc>ޔޚ(fkhdI6=zB$^8G ]`mfO-1&S6yd\`SlL`-q2| ӭs3˅ ,M3Wσerf(L#d+^H9E:>wʿ7w tXs-Z'<>m 8(6V}ֱ)زRE X9ȉj51&,eLD!~= NtqcskgJ5¹pyr/^:>3o N̳pgwvXXjXe;1TN`7P/ff8ֹ pfaj[I[ UAi ;i5 Sz \…a$hЅ>CSeІ,v.&m)06XwAA)2.3x-,\y2/ړ'?Wg3w4Rkg}shTQetH++k!㭗bN^r(\ȧ v1~L }uCP[;]@.07k(%l{ߐ*"\0ա=M\$papHH@@*A (HyL@ 437:y~X0[ 0b4#swǥE+u-P]֛߫3W[|c2֥Xwj'a|lLs#=FufTkgC\S_wa4pq,vcelcex1 PY@ V7`r01o7Љ4nH>t JЀAbN351j㈉ܲѨI&퐒 f&%fiwh?ۻܛl RLW`3y7o(B30? :1|aO"k윂ˤ@|$H +USFB~B6aá* m cMS׈-ȢkTvyUD'<1O),⭚tSFF! 3l"O9iBX\k9dh=}O /(0?@ '$lc81Jx,.AdN]Q0d3M}Ll/(Aar`0O2n FP.L;S}><N۳u JشAm1I0D %,.6>qp#q o7jpDY1,jL /C  O!d330Yxc0 (afPD3f?<K;Ոqm`(41.=&F3m'.6PnjY81c/도j[k,@[^dj'~VZ5szSZ4;kpRRbCfy ~ VrA^ W-B!JĠ6+p  ~ւM̳q ,| & *M”Mㄊ)п-R>50J@gH!qjYpy11,,hM0AM )r5!ĭ,\о0bd4'N&|Fw2 ؖ_)B*dY:B0Y[hbeI" ܜ$]%_a)I5IsŠzAM6Fn˔V%V`!hjn 665ẁI%dעMBRaXIUϞ%ALP>DmljT*N+z*M~A!Tֿ2GGJ*ʇrz|\o BUKXM\&$ 1jcs d(#"IBXJN܄7\ WkeY ̦+等 YQ'7|\& ALxn䴦T !6=#ʎYcB5'SP 9¶JFMñŭ3F޽%qPܚ)+ j1==Nݧ##===QY{{;TUx\rb!YUUsJ[-|gѳ!fdLTs`.`̐(Ь` p+@2;\ccd(|b&N2\fA=P&aBG^L#g?ly Xd >6QH4¥2Q#h_$yX@llwbg'Y5UUusR sttuEBo^cc} cϗBP{L@d쬖E2S4 1A+Anmtb oV"U0Ju籰Vxem%,p M3X@f\ mc4S>`$%ً=3x/dYʄ>a\1l8*T<37cbDD-lp*bM8i`F!ПICd`l`d# 2s c'Fdۈ a8\cU% }L @ٍp؃0m t~@fÜa 3 * q lM̯ .X;0X1$b1~d ?] G`4Gp@8A3Y" 4 2L0PBrIހ 0\ ʲbXvC8u$4$ M pH'p"2ԟK]-fR3Ygs9E2Ox`Ҿ~Rtkj Η[%؟ Ed Gv/`&6 A?,yg!osHi=f jԄ\@*AG?*Š Aʗ[}gsy$Q)9H[Vfh`nTojݞLFIH}㹎avy}:Q-oW f^ojŊP"h7Y6w~yˑ'4PB0̀eȱTp2US,=a4(;/ߟ7zj j?{rw^k#iF[=~<; FZީ`U t 'y ?`W !f@+г@X ]'UGa\ #!F[ϽBدKΰczmD]O7ˊ,$2AІꕚ`rH*uKUr3Iouoo׸? jD0Sylǟ%5Mx~`!t)hlG{F>eq/K:ʕZf_ !Tu DXQKU0Fa~U0Vd\i hpu&#7SծϞigTy\ly\R0&"#Xqdl6ilVXn$~~hBVOF{0#\`$v+ UM'rMB@gƭUm\^\QYr٩/) En4_7FFԍa"Io/&V;;lmf!H: "BU!k"6SB|!OTl, Ւ3Lgg'!diiixxV[)zcccllP(B-әGGGΞ=vX*r8~ٳP!4\Hؘc{[nZ(А"I& GGZw\}q.---OS{{]GD)H0(﫭F}54R0(mnT*NUUKٳg܄'`!C՚bhPi|L*^0T(4vwwϞ=+Բ-F!$II kV~?!$Ra؟s(!=5p@lr4 04!>~0dJR ===W\ⶋ`9qήUd:> u!ۛ<@';dX%̝lEt:(PgϞB1/^GGGH$nll$F +J>r.;nmm yΜ9S.;;;?~<55Ev3BlNMM=|PUUF JP*noVFf~xe2ÁQ^'2q88=Id-²t4doOdRQMRd2z.r"tvvyn+Iኢ(;;;r`rrrD"Q#H\.Jltp8<00N%FE;w`ww7H|p8L}ն>V bXX,VV:!tr9EQ!FcttҼ?88j<F%h;嚎33F9wl ,oVXd>l"yI5-ce||< aϜ9($I===~t]w8OMO;vw^%Nt"Y^t| *i$d{<j)K\;;^XiP`PJ8U~ !k _W7Nfg+FZƜNBJB|x(`&&&Q(Frr<υHK,Jl}fCa&ʍM0mOdFfF©nZ=zV_|߫\jXP򯷯PEGtJFQV#'li/+#SO61{-3fɶ'fѕ?d Ykx"N$>-2!KuF/hGݗdi |gMSᬌdPQ&[ !H Azl,pw%;xk[QTH|`ڢ>}8Uz*UqVA eÑZ _FA}4qa@CFL@X[D].7kV";TPg^(4TU}wWWW1hͮ?S~ t4??rn߾ B7o\]]u\}JzwܩVO>CG ʲ1,wi4 lo!bTmg 0bbepnnBF/:UM ] N`UXT֍RIBv#VVVK4Hd@5NB^0B. )e zŅ̧y0 6ni>A=f؀`BsB B#ӟ~488hh[z4___ۣ$˗/{]]]}}}+++$ ~SSStocc!Y'&&^fflvhh?ַu޽ahw-.V] : 62r8ILNz hoydĝNfgJ*rPHpN2Ázzzz}{ϟSUR,..6 ñ6==]* /@4_timm-HF"ZF7^o8~E"p8|Eg27|g?t6Z-AzYUU1Ɓ@@W^y%['t ۓBg622R*WWW_{~wO?a}]wppp07633sx<DRǏ{{{ekBGqR懖>2!2We~2_|83n? !3L4} ƸRZ-o|d{޹F}^;/>}͛t\.B~t:]T4M[__7R >t~A rIѨ2>n6Ȉ;VWVGG͎O*aOi J7n^IQp-,TQtJZ">|'$yx𠣣X,\`0믧RW_}uppT*&x<~Y *ЍDPi;!4==zkZWWM&PӧOkםNٳg=C!twwe(ofXbGGGi!ٳٳgKbvOMצں?d2' 02X6Ԣ#>rhzwX]]|7R) ʲ2erZV.V###|v7VDrԔRZ-EQdYVp8E"lYt< /<|XP>yRE2$ZՃA^uݘV* .ԥF(t?'BAsz]w$BHA^ĪJMi$TZ-?.] ΩJF4ucv1ƺTD^n> `MT,i LTnj!ƣdF/Wh4JҺ\.EQ^>,4pi-ׄp/Ll5R ,S fYTx<\,7 ǃH| WEzzG*pXuUU%Ir\JQ-Baws#C{1Sq",½dQX±A_'qn)XB ^o-fH4xa"6gXܳ%|̴vQHA˥\^*ǡ>[<>>>D"|> -,,?l fgg3L(J&X  NMM6Mt: BOOO:<ϥKIBVӗa%c1IQ I:ˆMC4AI2*Y_ojl`bN;:;[[[ކBhg=8X[]JZ랞fnJxSPHUr/ issKi*b>}zViMO@ŋ-TthabUIoś\,E)JxQUUUUϷtzT*gccc>OeJ l14ob)(UDcd'1s21!vvѣŁqG"><<, t TUBꫯ;\.ɓ|;kooJ4~iLRtuu333r9]tJbr&wu>r@@*uYF^.LFsەIXN;*)v:BQHB߯Bj__Te!400L&{O>dppP(4t:H$www/^ά@3MSXv_ӧb[.|LWWBc} @ƙp8Y__ؐ$BJ\. 6\YY!$IE9>>P.z02>{EÄl6KK$tehh^jNu'FuF)G/oi% yBzib;l,-Za1f^*`0AJ𰷷 SL&C5$@[#j&*@cժh/{m;1Q%Ö=W8 (P'qAZu:ќ"tv2C:99)$SN S)7HY`˹N2ogg-~xeb+42C%0Ge0MhEDPC!B~J-r I:aq;O\c+,!vG(T$_߄F`7y? 1ZVe> @dc)"$mob]E"01^;:0p㉠cT*;ܤ\.CbjTUϋ rp(L6Ri|ZU*55m5::jXZʑ;zDau;;j۟ T*ӡAPPVaJ8$zBS ;; +Kt[bli+v775H9N 0uEe&N\fu#h]ZZRzQ,t^_ =|PӴw}^R@ ;οzG}f?DǏ?{,L>z(Ly!DOJD QioXkzH2{gP muxwud<^±Ō,䙮bocᇛ_O&+NBL޼9{޽fIܹsgyy?|2Bh+J~{{{{ggÇx LV*G}l6Ǎ7?~h4o6 6H$GAj5E̬ ߸qV{9L&#IO~]{zz~ӟnll\.??rյT,Z6ݣ BzY[nፍt:}= ZJzs3]ܹ3>>~mBiQk׮hV[NgvhbXT*o'|255E߭өNy:eYju` Gn޼[^^Otk{{7ϙ~_looj.~ibbbyyymmMUt:x^z饷~{R|>_y񾾾D"ۻi$!7g[VߟK$έV._Lx;*;sS\nhhΝ;VҥKj7HVUzt^`ӧX,vƍd2K/ݹsgggܹs xc<33CyA2xq۴rtB9aQg>pqdό"F!c3Pt1(bP ###>obb"|;ߡeEQ% z^I=zD$FH$rk~񩩩z^V{5!*Zl6_~xx/SIX,==By<@MaAᐇC^W{{nrx؞ls` o4FC|Wu24TZjZV[t޸1x=z499D˗'&&dYNR###gΜ ?zzzn?X*5E9>>BNSP(=zixp0Hzz޺uܹsd2ぁp8rJOOtttszII$2zWPh#px|~>BGr?X*QQzXܓ$Bxkڍ7.^/41(dV.'!TٹiyDAǀ,c$n 6RMb$.ܷ{P-eSNf5mUvx"uj93khj5o BMpM4(gl)IZPPfl~z^vC-X5B,舩ڟ8b](UU'PA&+ sҞ3e\. fx~n"qg 3x"'{8n?m6ߪyL!^oVs|Baff& ޺uhϥUIn߾MN:v8KKKM󁁁E׻_[[d2D"A_I&Tjsssgg~w}yi z].RI X3g:<>v8z.TRINN;j\,r:Bh~(գQ!Q1?l,'ObQǵwWVVjZ.K$drooommmttc\,:}ɓ't8~(޹sp8}>B?w:D"qttvk6;w>~8oݿvkI:::ݻWV1ܜO߿Hj܏oTu˵M[[[>`xxxyyYbh4W`E#{fs}}=P7( #P߿G@a2[[[\uM|@ ii`0ph~ 8w_0 BZ^A\Vvw٬PP|>\1FRȻ|^RI>8p9ܹZRLTT*:evgEJN\&N'.3m49ݑrtzff&xޱT*ET,--UL&?~Fwww+KKKr!s~> smllz|| UST*~GGG__~"#zVǷ!Y *r9]i%Bhoo^BTUJP(DY-Z-H z٤_p:R !Dgq?6-KR޼yҹg g9!::z kkkX,LR2 B54D"GGG2\.^wwbJ=ioɕU==[YYh{םwNT4 %Q|n-R^д&*?RVBN*<T>_-'j a'$# 9P*h`2H˿ŲYŏ@c` Qօ :7!4s(=:j"( #sHکG޳ҝ;Vf0L'k.,HU}v\C9?l|^ODG'6ѨdNTRQ0=[d9NòL(HcfqqtaanvAZ`]Asw6t6~.b6QW'!kMӸdeEd!l`4`-F+NA>1*\kqb&P.NE?E) Ҝ#w0$ gC(F&"A(Bܑ`Zٳb)c0iѣGdXբOD7^w||wV*'O8p8|ttTT իX,v/..v,CH$PJa,|q&r^ Bk-&un J&+FsHtPhi4 QJ1VkK1 H:~Cf*r쬶ݻݮ2''ENGJZaa+++O<(y ׯ)ϟ#7ӧOfɫJ (٪lnmm!ǫW޽j?8X, *V$Aab^x9fQBNR@ٳg\nrroV`\Tj5TMV;>>(ZTw{%q~m>G8W#G ʘ替rw||LQԫWJe6=<}*vSN:0py`\BB_nT*6- A0JOKdyBB0:IQ#ɨp'lhL@RzA>Dnw0 ˡPE666vww777.KTz6:ikcc޽{wbbT* _W;;;&)LS:7jɜ9<. [-f&' zY6iD"~x::2 5zj /4:tss/ݻw20r7y/fz*aAj5˲(eُ?lrwxxH4څ m՚Jle硤~d2 Y١Fòa\|1:!hJ%8D"q}}ME1 cW);noP RI(pd䎚LVGL6`܌F.kyyyvvr|g4M QEQw8N<`6|C//--!)EQ<xÇ~H$BPYYYAG EK77J.fӹ\FHZISnl4MkL&gVX25ū=/ӦөhT**<̓^lO~FC۷MRs׍Zѣe2 @ \._>liid2fRkjukk@=}'_,JӴ^gRdޕu)j@bx̹:?l;-J#Kz!v)->W&{+0iEQ?$+Eq)S9<{ewwwrr󽟌ϟCK}ٿ/4_GK/4YG&rH ÓL zmΕe3㩧] L)x|wST[i: $݋8'THx8 N_@IpXt"AV1}#GH)ձߙ$I;y̫ 𚇳 % z QI0wDި`/wiC?!HԤp+;dm i$D$ N}M2Hn3Mi Hg0uGФ;D4hĞ4vH|#JɀҞ q(e ǐd-&? 7Q(p#iHf hp, @(F#1$&@28lW`r3f uH6Akvb2H eN9DHht]\\— N*"[JȁT&P_2Lf~k cR# SrW$'&R 4Mv(ĉn6Gd[}WGrdx%l] w0/3vGlb FIQPrʅBᏏv?}z@ƣia j Q[NݍFӇ1 ȶZnNERy YFӍF+0 ^=;ZX(vsS6|5;;vɫYg^}w7nwNCLpvt_E;w޾FӅB5kX&w:B,Ḏf OM9^>K&s(oh4ժF۷d>_xl4Vk]͆sMh Z^pZMTX)tkc*RjCzBAe2rnL@<5Ѩzi郃d2W(NO/+?.-͔J̛7zhZTF&RDJE<~kbNB!Bn,#'H|wbPAU }%n*P6H%@,jm"uU#g';iHjsZ IӅmo"+ rixE%#>pE~a*"ȹ\V-䤕aZ~d2(2nw *Iw5UMO;YU7u:-Mj5wUJiu:Z:9Н^)l\XV6Yjs ɉ }0VXy޼NNZzmvV+ffV(BAneBR&YZ9=|6lrv;Ͳ-դV+ jm-psSXRqrכ6bvzm6^h4tZܙB06Wfg]f{ii&Vf!,/X\6QBufhp fe[fqbBqJrYN MN 2LSt$ܜGRv:]^{P*jJR RN͛sffh\,j6I[縎N/,Ll(lj4&X(f2;ཅT\OBX@<wUVHa_>2..罷K_\(P:Q=X}TQyԟ!JRIGOqX]h40mDRvy}}Śxdk}}>D&uqu F߿rYk5f3U*cX8|kU*%@Uj,M) +&Anw8h$Z5 C_]~_*\eu՟WN 0@2G:034$0AD4GZ\Bu$M9Z#mOQRAʎiʪc;=Kx/ 1lRV0 #I'qU 'jJьbRu~TJь^eV4nׁJd2qO?]ߏκ4U*2Vܜ7TEBdl6Y;|a77X-4m4M>Z(@Ԅ}>l(`A։9O4Tz]__XXQ#33n-͔Ju$-3L3M3L+|^m4R!t~_2!&JET*S1;xIDF[l+͐pQ V\%G aѵHrmyd'1{;d+RET"$#t S%7)d]NNL{VPO]]u$I޽yY l6y)vyZYBM A\.WA޽@m4+榤өՆJbnw?l\fwvg|>n+*;;;yy* FtҢ>( zT.3\Wlߟrl&בUff&u:M 6Z' wٲNq:-f~rҊ>3r8hĄ>)xif^QUd^g(i:Vr8h1No'E<l@Hi {aD1+HyP> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 613>> stream xA 0 =fy9뀟\cz~ endstream endobj 157 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 292 /SMask 156 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 300 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 97415>> stream xi%Q qNnwj_nuK-%dIwlm0ߘlc`00lÀrk_zVo7f{ }Gu8q"Dĉs2FDqM" [&](,1zaW{RH:(م(;vwy'GBvvwo=>9 ]ح(sfv0s9ݘY1lW," 1EP'ѻe'a;BMpN*Sᣨdٱ[:(ںYE-5CJ:%ڡuqMvSN{:EUB DvF !;Q;f4JVu7=UI׎[9=خX;A9zn<ݤvttp="0(⣣t_tJtBu ܨ?bЍnt0m!w=]I:u+gQ](׻M:zzzNX&#+~/x\!箮mV;~ SՆ[3+us"G>'T7 8zE7vsܝ La^R2;x7GzQtNg{г 0)m{W}n\O4L·Wv0m 粣.w:cu m݌D[7L`Oȝx `zqg']?/9Ss~;`ksyݿi:*//|aD^Y_lܕ;k_|㹟h=*cS|>kʧ'o94Cȷ^}y Z6+~跉HH9Oێpici znZ7M)TgW'O ?ouG~_z"}/oeH?c/ {FVrtpq cjmQG=vW(+^)drXKu/ ԫaWa9GqO㞏|x{~o?˦|?{pM~îh3~}?~.@6~v~/>#\zkަe|xW}ӏ/ʿkͧ-&$ǾVkXCoxo_7Ot~/~QW}g.=Pů̀o#y/>C~ow 0:{#[۬~1CNqQGG|{]ZObGgvMA{rѥ!LS}%S8 -'Ηdg)P_}ϛ;O=2iמ9l΋3c M"2-'҉ɷg?x>1m'LvlǕRFP[v` ϧ$|"$t{6wh@]~wc(N?4J9m/tpAR)nBGӳUiG_wu݂ކ}zuhgO%2(˅Ijn ^;,v-:G}JOڰ+~ww{s'N!zYxG _Y>=*n>ܑ#x˯}/,^_;ˋxͭ+륁\|st{x5OU]:ND<{i\vt/ģ/˵\ZHy-?೷g_{✦*c|fvi؀+Kfxx=_x7!ۮ_]*N?37xu5nw޴v~>{봢~~bp|z}wqޭ6ܳ.=]KҶJ[$'wyO9^v"NCaF#Dv-{NK*Ndtw9guNZS]xyIz.2zOCOvuz]bn򁝗 ݨz2u}zfqĀ*b 7OOxWGFz6h? i1zaG)8c38f;$駑h;$24i9 RUN;]Dnws=Fwmf'lhwlݻ I=ۓ]IJpk~wq;ARO9$q+=xMD|d+.xS/^](dz\"n|ӳ半>;Si 糋V_Y(' ·ʵSnj ]797_oZ?uWWpv.\۬4~8מy~OiXم⑩-]F?Ģ8}_yǦ|ov\%!.{:(1 =ͻ\DưϨ(`R=[DmeQ =G{UtnnʣSݚm;7\,_^X_]ʷ\Y*~ԹǞ F?6O/:ԹÅ~Kz>e3ֿcOԭ.\3VyRT[Xʩe>g곏=L2w_x|r01\Kō{~f o}!7U,վ.-gF{ő/>v1NĢS:S7.}:vK-vb~OQEPn {vGv=NSw{]dmw7ݰoētӁ1WޑG,mg hh԰42{nWʟ8\W{bzMr801K'r CD\v_6y=#D3$?wvg.gb ߜ3Můle_y|_\X٨;n8z`'C:;=^MwǗl+&:w~v߂d @3&|Iz]`H{.QJm^xN:Hpw;n_;u܅(d7pBtz [=Ӏ[E$cwRwd'^Gu>%.4q^/lIvvv7j)׮䓟mtϧ&DnF^iwK#y蝎 nvׯwD #lىbv:Et?6\^&fw:쀳Si:=cJ*T\&),ȶiy. 8807.j++x*8-.P,͑`DQ84Mz/'ؘɹl6\4T50 b~3T\8@5^DgWp1r_D;w#Da 7WBz$knƴJJ\sqD_Z;2MjHC^.W̙1 X\wʃqU %B̕-o OйmĽD\* NrciӬnvx,T17Nda\Xs;})A2u<)UƄ$tdJS @)Z}ߓ! WJ~yt  דo86הv/+T|rdxn+J2}h@;la()A"! H$4m3Tޥ3\HZWjYC '7~jb͹P:|*vp8yd!6<džc ~_V. a Q34ED"[ep-oyG7 _g{|CCCpڵ Dxhոw^vmrrr~~~bb J%5 EQReee%裏fyZ-ۖ?ocLU^ukvv`0u==i}߽cax܄}jU<_7׈j̑P|­CczNT8n6-C(r KiIdɎe)'5zt1D<8KL;9CPΐ <:Ojp1HRE T+sT/ q$uZDq0ypu ǣ-1t<" L l$7?ת/Η ,)7h{(K-Hr- mqlݸ7[iY(rƲGV.οBe+h7V hN=Ӄ_=Rٸ\i8s4GĦjȵQ,*M'ӢG2{'{¡B9kkkgΜRΦRC?bxbwsN D|ǯ^SOu]_ߟ,?sw|w.wϗ.]) Rijjjss3 !N81==tR XuJk o?g>j\zLQ'._ʩT 3 p誹R3 kUǜH\\^pw^+ 4] 9)Ε59GCQ|($5]4USO$'6,O*CBΰ/a0$MZ4Oj$9')R:|Zt-GT ԾM8_Ⱅc{כYtMQg:iǦH: nWV`<-۶ox:d` ,XEZ$ԁD"pѣ ٮL$0!= D嬐J5Sh&0ܳ3d0wfo0W"uTDYN<977799:S*cD"Lٶ=99Oi}}}[[[bÄZ%J$zkR7qD4Ms|||ffرcQȞ_zucc#۷G) ew}.\a .o+{=ܓ=Z.٬(7t??22+qTUuiii``S;T*y^6f遴$3t`b:>>I "'g|Z}t>#'snަ2-fbd:pdL#2`ܪ9^T}I6l/eh"" 2WT]b±] s+Œf?ފ=&QɴZ>2)$5ŭv9Kܶ/2=,IM-/,U]Rh2c,S8ͺ}Z98҉;~n8y2s#{ '|W|744TחGGG\r=|jr5&*c3kLBu2Xnͧ#IMC "Y(O1@MKꊡGMS_4kD'{7^\]]ǗJR^ؗtU}#gݺ`Zؐ_.OOb/٥ rtLWfʷc=tcCoHt맷ٌO 焂ō8Qɴ1l6tDRS豙bqIUH)MGa|0Iٞd\OrT8"zRjK׶*cik%EbnzmI 0)a(k{hyjfpf~f~sW49D*BTY36[(R<11_l 37Mf58,,R*X$(FC25"g]Յ&7fDZ߶'H:d 4KM'УE]BH(ۉ&-=yŔNZ pC/Z芜9|f ҖJ=dtݘl^Ww" @@vf/>KʷNotQs疪Rk[֍S+Wr+ GsCcZ˩3T/쭡بUʸ!*)IiW,J~x$ӔlR4@Ι ΄"c#$QJ\EX0!fb鈺5,P+V(+O% ê" gUSxfMglCdK[\Gq5MD Z4N]ܨ: [P*@I 2͚ng 138FٌlDq4M $덍K0!!CV+N2zRJ2T+m44Tnyrj KJ"0"Zy+( y I_jtPQd%IDD2nֵ%ϗn"[v{PM8jv,3ETJ zAtvÜ#u (Q٪;$rKOr ۗш!ޛ=S7@WkneS9y9xDtlpbUĴ~c`(>8yM7 q#GȥĭqtēRa{'JD*i-m6if C!gl!51FI]%2|JOou5)7f )#`@:mh*lnMh.(mgHA!RuP_S kH$Lו?Oo#($tU$?@eiMjk'Ur ӾzH ?׿*ŢiB! І:]StBS҆z۾t]O Gd(\Fv-}w"R@2'g` }gS0"6zT&DH յzs(ߖ1q{RJ"_ghhzO u%\oz˜'thl6%f' BJkMWSECeKHG'7B@Bjndօ I# g9 <+Fɷ\*uEȯWg(郞ڶ8D?m?mALcqVk;n-$8R2DW ;yyCEVpY@y(گcckwRPtt1D3>Qnx.u"DEY/$1@I 0逨+[a{j/>p$LJͤ\êL4 A˕/r'MLĄ/69" gLJr )U8‘!ZB#2d (kh#21M k ScYձ6jkcjѓsM;:Y-Y)5+xv"4s)4M;Ј7'!p&I<'J mXXX~[qXT+}}WHݾZYl?> Moz}&H0d4όJ)OL =i!6mϯi{$֪VRS_dؓZ =o/|<|r*qPy6hmm$AR 2 \L )붫pWʄ @)/0J3)}q#_#* Dd /[F<6E2^-m !W.^Yg@|㜙ɦӌ1u9e`,59'n`G# 3.@ZI7GɌgRJih^RWmONp!93T޴pԐu#4ݭQ lcV|! O.=}ɴcW76*/? VF`*maDB\X ,aN T֑;DD9g0DC@hmwd>%u=w郈TՓBXk BJ(H"cFc0\T9Q&{dA A+ذ,W5:gɕJ3)C۪āt,kџRRst1) !>w2_B"!`<4'olMeRR*2rbzإ~DaefۀaM ȴRJiBYi[9`R$ ^Ar1^o˰\ƒ0ks`G'3{WRliZ5;{V5 UUu]vm0[ A(1CLpuĀ ̟m^-+9`d R0S Wܾ2"2k)}ݷojjnnnxdxkk/zq}; R1DU%u#+dG 0xЕ3T<9$_L}'"Vm; !}SvO/f]!3FD7p3KT p,"/=}91߇w+?]<;f]>Oؿ'IT Z3ܲ6↹.=9mgݪdfvխPLi :kV.6UHf݉k,B&yRj SB҅|N2(΀pv1Z#I+e`/i$*5oͬTN\]o C4P|A&P@Ki7•?mhafgf׮QDFUKŔreI)eKg'JOquV7MNL1@IrnϯWd ߾Cqǝ\YY9ywIb_`;x SHjDZ[1 zB-L\K|Lhjۓx/LRfR?~ר`uܫ0 ^X.ͬKup'IdLUf֫`glXLUlOHJ ᓮrf{ MkC&#o "@JI?C@bGNml|޻^,xiY;FFF=_(! "ΘBCt8 2] E $IVk%&2$"}kv+[CՊ|yj0cݨ__2?a5ͭDߘ/@xoV{F }cŵS?hFhLB^Zt2JN/SpV۟9j.ݭgֿUޤe6_<7HDOB3?)#Jǵ[ r6eaܳE҆kfݩn{ (NQgדk\583|n2_L`f(6yH*`W8WtJ) I" | eԃ! +Lkh G4=Op/oo[ ׼0!*`\5Czmޠ2u+echj!O| 5ԟJ}aCAV9>z㞣'x6-볳s;TȋXj֛⩹ҍcٺ-l5MvoRƳy?m hnzB@^RRO` G!!\!.˳djZ)JW`Fcz F+H2@J 978omG$5PҞahiBpfW#Mnk+-VP{Y @X#v8KdL ̕i>ݹ_Jt*88=V>BR=}6_dx6|)xRplo1":{riaĤi;L$Vݑ҈#C Y"+vz8 i£6"!T\I/.X.+X3J0џet/ @xgUE=*}/F!kE$ArԈ|X?Te9d-PcJJ<֭7Lf3C-1w_sm t~Ea5=I#tB'zJҺY,WDzqlIg QC,O@BǘGAQԞz" ᑑʸ_@B %;PN@PWX:bZX5E 0 lkAcQPkl ^)Tw( Td^OZ-1/״J}^խ.6'dͭԬmHͅ '*͙^ar*$97Gbx3T2 4m.jJW)GH  6lWSp$ @0yf(ɖmbn-k{aW2m^-sHg q*P&f5C%4DV` .Xnr9rw^[WU=kNbaaI؆f( .Èq8ɠp0CS"G%B6W"ys 4tARD' yۆ} 4\o4zmq 4;֤PԨƝb *gF2g!mk97U= BKlZml7W L-Q_XXBʫkMhiZ;hk=ibщɅ^(;[MLF"1 TPD$)Y+ 31"%",%\dj_nTO廏kk 7Zo) ZZUW4 ҡ])B~}+k"qBeeO\qe%JBcS2h$^OO;LY !$%cb=SR1 SHOg H WJqWfJi \OLcAERH6-2ߜidIvvND=vm3!(ZLP&d6,٢6,my#  6(B"ġ9 5 {/y8q׬†Y7q9q0 6DE;g}*i5L"@&EQN/5'wH}|2yowPL.gZZC8l)6zFv w4댉cԗ+ôFov){ot`pasjF$kH,LHvti\EQ3a|4_[m)lomϼ MyN#-8B%T$ֹؖ9=̰KJVAB֖@n!3f.mQm\$f3Rv\)enJ=5.\ysZh4 ! 4]1 PqRcfEj5'c`$&XIF55Ewgw/+0<GW-"ΦGz}qiW pĘte9Ydw_˱ j* pL :hj2߅ۖ/C)Ђ酳8F9 &cٍ;+O~2(LO)F9YC@d?{kr[AW_aI9ؽGs?~|j- ǎcXێ9LpX82S$T Ù,a?8 .!ϾZQ69KYlxi&IiVӫ[ƙy$4'l򯐦҅Dl#Cn {ʪ E`,4O&Eێ/\ϦaHt b)j;;k4 Oj|xxڵ\I!!8 +HOR2tRƍZݱ@TJ8Vf۲'{kk$̤HsLKa۵1V*iM_&ljB8C3k'/m5Wk6fˑ̅X FR}t<~qx$"Dȿs0Jx5*xg+,J"Ip}鋝8 )se@Dm-uZ pmm]Tm)U;(9;qCNOOEP( [i㏿S|:{O~Ƌ0E{qia٦ ΅Tl1+@᪳ĕڮ^Xþ&8m?;5*VjYB `˳jiT^Djzl8kW Q[RG$RbeŔĀ%ܵt0i?ѪzhbJ+UskĿx2Yg7՚tF1d>smkԿLW^xvU=VA*i.5@Fq(NUm;#h7lдvy;u!91 b[0& TOico4Xb5T)řhj&gϽ|fGkN }]5~uqr FF2RD%uiGq`8" ɢ"H"L{:F95=l>d9L8Mb.Vx0}b#@^6=Pow>?[;2vU1` 4x-,+tdp0 jOmTW2@`J|U#?F`/W&~Jvb -ƈH*]3 IJkEZ4+jzFՆ0*՚[Fx "2LKɾ1kBū;-ɗ "@{W.\/ӫ//I`vs׻uэڥN?'i>DPjP||Ӿ΍dyn]RiV%D#McXAyr͒@:T|kzv@>23Ǔڜk jlnkvTApAZ") 6b76j{EDV8@۵p8Ӛƾs`fQd'iZ182*q8oLdOd r3b$ |'+Ԭͺ;+jUB+SZݖZ/"F9;9tRVV3F>0!CVV;x4è55.LfS.d6 psm!GXYB6gkN-iɕرM3u\jwH$Sk V!Ypj9é/?sH`Dz̪%M*MeN !硜ҏToAL$g;ih0∩`Li4-b rWa;vYK|S6dս`Jek8bאΤ@eիV<<1Glo4Fj©6VVwV=)IkkP ز|9Aۆ4ҚVk=jB"jV'v%sȢlf zh~vXnH STㅯs+H-Kfj* |u6@lԥױ7o޻zpwkc՗_m; EHI(ՠ 4" oo6xr Cp@(m4bPDTuzx6?r Ѭ瓐"m<g*vϵfrK]L'h6b`cMGh_OG٤QkLqթ*!UR)L. H%^|w|) aaE纮{GnޘΦՊWq+Hh\+mVɹ!WAtZ턩r ^ڔ,tc@dk;1XnT4 AkD0UFCap''+eDV񤒌1tʱ"w׆ɚaiceݚ8Jٸ{ J" G0d2+ӔazC„ EL ? a3B}L'nRF6͟sPs wgy[VXŸK.i}7{M^MXCK)Oh ߬[i!neG LzW,CMaBn%8p4[eb޴;nu*Atm\Qb{[uU#TǏ]׽~ڣǏ?7*t4L0^y۷׮Rk9(9t1WJ45F$̴nQk?oʯʿ?xקkժy^om}]kǓa718:x{m ~,bg_a`VRFDTF%B0D 㑔zZK`?Q{6Ostfy@I!ݻbx,R!`Tj<QO8L.-}+)kfrw+9 |sXInȀ1'R+@ E!# `\)CRѬ>@k֤`&-RZ1RQ,kh-yz͖km(=YTt2<Dz Y`6%U' X W^yl>tRk4(aCJY٪WH h{{[JVhmeqb1魧×[iQ5s[\r>x6:⥍c= .7̥n(>,"ީUn^ڋ/攬(R~~I1V>ZY5Өd{2]ʆК|%=}t +%)ED((2)QX`XGPg EȘ`0!%֊g[pf S%yE$!i PbJ+%57ĜjU++ukkrO gj7|6U/q$L2eFl1e`XozI:V7Rѩ$_? +ng&A$"T>T{,a˸wsM+˓F%HR)O \0'WT|=dղe,Ak8Ru0_,NgmEJc ۶4-C @(&ciõswSWnݟ(!5}J]C^675UVjxMU;/\2w I'!B (P$@lg]zn(ӡoW`cBñ=y ʥ@ơRclZ:g²MWhn4eōV۝ыR 0>ue N((z;0٦TZ0bP$scfq2@C00j!FBajU*~66~곟JBQVw-,;(@q==>7n\ăǻdl9&TTlKaʖP+-4 X0#? )jYE Ui 1 Y&[e )f(r~% aNL4gs8&B nBZȓ $\xBkIIlVeN˲^ڨ_Z*ERzѣOj g˳dv8_ڛ<:H:/hX`dFʔ).M`d@VRShm5@VKъɕdn_yjtbn4\V93X*Rl xp&菣?{2%&+;kZY@+ڮmrHj~V[퉚U;LkA ʛiҚ$nw<wZmm`HԫU Appz1$!)FI4QU;rs9&n]ݩ0{N7学m"RP%/)ѳ+RUTܧ.dIQNv*7'!bɞd13J*\ҽlla0s *j(L^\WD Q3f $R Ɓ4C</6;UBj{ʅ1xGFM#)ixgwk7\b % ] X%XyڥVKM4 blڒ1h7Yzp`wwݸqO&W/QQǚlCtEޣ= 'Ӌ*U2a-4݃Z1EF4KwNOm/ f[_ФwynZx炶\n\ljhWA)Nc DUjsNIKHHPRٝV' éԻ^sc[[5nsosy) `%Bd2Yzܽ{r||>8- "#+}2b:^Z5{{~|mAR?띙F if~|~x0>w>[Gh4DAKi޺rH&jzv>{jڰꮳxԖ(qFKhTw P*YTz!U=õj;/^/޸|qwWg&_Ӥ?:n/bY@[RU)+qeBB % E"sJA~:O.&so'9ܲ 8߰M3SVj}zjqΝ;QOG~VX^?[[ b_4-_37/@suvuWnno8 'A|o j?~{28'{ߏ*swDgWt}[Nplb1SP,W.Ej#) lVݖ,-lXz4#.ru!m4`gyr[IB ?N|SVhL!m[m,9]~O}jf.=ykˈ2? Cm1XKS'0p2vV+WeQc۴SCVTX,sC4mW??2 cuuӯ <;>o?k ߬~3nwVFRyhgx?=Om>ȓų#ֺsK .Rity|\dEo3ύ8w'>zm\|;+;{ .oNcj}?5X9ZF_r2Z,zfBH@fE`f>аmg?Bpdw.]<=7M{+isd^H8FD0bAW5J޹?U>" `iJi@ӧbiǦ~{wFσP>Ա"3YfI~6[Fٺz/\|nbޟD23c #֚hnqN' b^gQG%٬bRy^R٘ׯPwv.lo-8'QѪ80g㨓x>8c۲xǵ]4O{irh2L&Np8lnȯ59kxpִg4Tͪ.&W/oL7OޟJNe8ܕKnX^!L}S.K)C,JYJݪfq7cmJhT.vWvvֻzQ'ˑ[6eiB_ Dz S ! Ї3Sf(TI`Z" ّͪG'_tfC@Q/1R`E4ŵ"~|67/kZRtF|aџy4cgd ʵijb hJXE ~ɃG |w80B.PaR /U#9ͦpԪN$hC6Oy4 6VRr#X=XJ:!cpee^zǝ-P >a9=K7֭Ӄ aq}}E7v6[}aV+a, hSͿeO4E1S;WD,꟞^~0b!ce;70HZ)hR"LUiY&Vb\e lVcmVvG1 Ҟa9A@0mðpEZCD`dkk$B]QAY8oV>&rv^ܨI~7A2,+)bYoUO|cكɓ)ly+-0+UjiG~T  ?u*?Uū#bZw,w>@nJy9W^001Me,V+dr9*HIv]wH-u0,4ȴ~/b2L&Da~e4ڑھҸz|+[[[o=>~$ϓAn`LEP*j c  J4=yvο]tp>ygcs<"wfyRH>V@9@ ]o3lBr0L+CY-">朴fDZ8l9 ʕ=>n<nn_ۿW~??97?~pdE 9NT{i;fL(˞=|qcްQw}f~iQQqOOFϙ0ҪsaUpkTn؇JŶEeơ$"Emi0 *I)WJ2Z`6UDv2?< Rǎ0۫;ohNNO+^ms-f|2|aZ˭"M@h#d=۫W}}:CUB?O-d'7͗VŸ?o;Jjz~Xt}p $)?++?|睵5fifoZ hԪ~z^-xs+S?Mhڷn|ѕ"i(*NΦo=Oڵ/\vWw.׻giG|闞 @Ԭy陑V&r@RID8fbJ0+DJk lnoYZdO֝ۮfӹ?;8xio|cٳ5a l6X= p(ɶ?|Lˊhtmz])l6W]ױ7!!k#΅GDtoLERJk}{wpax؏=SQ3 &Պ۟?~:ho"-U/^~4 V?[s)CK"HLHMd_k4E9S(˨Vdr¥K0ʛwC&Y&: }vl 1j`ݞs@nAp! bLpX !b1|i,UVF9& MRȶevQ O˗YYmZO6ߧkEP:sKf˪EI ONNN=3 47|soo/Y+}ps?g/ԬvODH JPNh8MsS LJ֌2-Wh9)PlIRJ򹻁-?Õe:kӕnwO~u 5Ȑs5ѓ.(1(!EԦc) Җm)?<>88ggO>͵&˶y7U0V;Ùn?Iz `8f^8?&E8XIWa|> mDOfv$Z bE36jӓ [D`>BHK69wﮭjM+m9xL2l,.3L|4 •n(~iY|̑6!rόg~܏PE`;">byu[ʵD ȩ 8$σd̮R6z*UTZF615G*l WÂXa8ɞotlwݰN͖mZ';UF1$17o~wv/9Ȗ<=ETf]υ9Pqf(X[ibK'yH,><µww:Q˳ \˺yh2nz3΀OLh1!؇cDlzN۽w8 "̵2(KdC!k=}n)]31^ԣd a]K,BY?|ٳ%y'}}?w{э@DRVLq1p`%~s(a?8HF +n߾ٷ:燪saqno}Kei$.ffZ&0 ᳧@Vqrv^T\5<۴O DSfEZq]A"߽[Ww!|U pvr^%ĆQi^8٣jO9WeYVZ-iGIZZ폾L$ .ZEI3MQaQh|Z2z PXO޺Zn/a2/CAiPZ-6?P Ĝ7K d3 B⩚08kWn,UF%_T2٪g},Xr ~+/lcln~` GI٪td-NZ0rEGNn.˚/,:%5=d4?(xe NnwtDôVD@}c..^/zNDQrOO1B|qTz靛7 °V)Zm@g !f"~gNnݰX-Wç.;50EZNNZm~~d^1[!}맣gs΂vٺ9#Qqh(-e+rT$B۶8kʣF<̽c*Sݷed>8^1+^a,T,SSGQBP!$uS%ފ:F(|Ѿ]n`6g7BbT|Ra;5n0?pbz>^5qGtszL&NmͽgLÊc[g,-0㓮JziljFQ/4WM B2޽"]Eĭvgó^kFqh.$ixe? ` Ϟ޽}GH4+F~rqѩ d" Ƞ8oCG޽C4\W>:^̂"xm|GITadڰ6S* ZR's2-˴2^ amڎmϗ^Wr^f} 1@\{?htqnKʕ ,A*Sܹ| Lƈ!Kkj, l{ASbK% %A(CE,GrT,HbC"(&n3Fsư^ݾ};l֨ :*Uz!$33K#V^P8{6TE+/k %IW;e0IZVK~ʵbVvK%UȜ!u>赺J91ʝ2@N~x{{O?k4ȲkԻ֮:y7 qM]bU5+ΕV9YOxZ "Ce7yfw[+U8Nڭv!Vaprz[&jHŕ=ً|~u UZU|~k/7~N{+i G琦*[/Re2@t@\ /#MbY<A߁[ !R|#^XЦq(FBU_w1L!gJjl~HEӧOyB0iv%sV-GiGC?c&B卥#ewc97Ҏ̫nl8(o\md>ʐ2%-%_fvcbVΦ٨V$uJ%Ջ 1?\4M8ðh4[^W3_<9j6h6j aQۥ4j+;~@%._>ȗۏҿvgY>z=nݺJ7n|_a@ۉx0|fagbxqeg1I &fK !@{HzwĪ6گ? ӤxaHZ~.c]:5)Flh  D Jc]=%;s-wq-.:U'sӐfEYRq?aO0oVY2y>W,KBhxo>X; [A|0X]$ɒXJSO5ʩ K lKP++8r=2~#ۮ<{''Q:nTvmg47*|*^j4̵^Kv9_!g# {V`/fx>x{f=0^w_Zlֿl*"A N?8F5 Nlō7=zdy狹l`Dl>]"jzle~~XUx:]mۜ!yatƏo@(;ఐeӨFRR?/{|e-Y5'}W)7~38*Q@;R8YDqU&ɥpZ~!@@Z,c|"WHiJgΦkX+߾-ONK?.9ٲ{k#J3HHŲ7gXqMD\x 4rJȶH$#1쌧JN&Yodc q(Jh:Wa b0\^Rd[vO<}7L3 CTZ{^^+h\eDË VJ[/H=TA&.8kgY;;i.T2D~nhe2==*"LSe´4*^z0RlrΏVգǏ7y^\%I6cK% 4)'d "Z ת is@ّDKƣW]~mGQ* *鎢&AI$ "j Xc-]ܩ8o\m~r2OShW;UFh6.:ןD_LDd{[pdٳڣvU*I@5U86|$9QP$phƇyj^'I2;{ppڶgQcn|NkqO@ .>6[GZ#"hpdQʀeny>X\jNt`Q":V3/(]0"1ĉ9_l,R6|l5 14$(;xy0N > C^oI͔QD2"hD!vr=ՠ"І!r(yFm?}pTBeРNJ!Q(R& sadzqMNsUb /3| 3?L/EZ),60.wtu߸)pjX%[? 0 XDs,2R2"Ew.S2,uːUB%RѢpRW\_໯wyzsWSIu_V`` BrO/‚@3=u9I&HyŢbl}8e7: I|hz@N@y$MRrl%@,y,PI1"D<#*T8IaȀ8{^q\LϞ}Um;]xrpm .?'m;zVq e@$eHnA$%vt6cbaYH_LD.HLw27Ñwo٤ kճiCho@@?U^Jl""M/oݺzx-x~X|H)Ry%d>HQΗ:YxxWXz Ai +dyu>`ޫB˚S8l,-mT%4u-]0Dtc?ׯ&"X(a&齽|T6i 3Fٹ}6Bz=Hd>߹z] IW'$ }$͓ ^ Q\yB $"giK`zWW'st#JPfˉ gh)XЩvJ4*7(6E b29|^&H$MLf" !"w`WwfY\M$|; 6pg{g8qlөNj:eZ&y^:Yqe%BM6yRz0H[1FD~N[a k!asAjX㵻p[+N+w~-WLd0m3Dg)$. k$ǁrPtSOGnïˆ2D)[26A59EujHn]M,.Ɩ"tnnHL`(eҒZEv3%SZR*Ygq|i0lV+4 T?Ͻ!C~] 똄.n/O r+kӐMWw+jjT8&q=/i6uMWvww(>j!8" }3 &"y-;Vej׊dG)cU]tS_%%e: >=Y|~&gӵI$E$%Dޠܫ^~LU+u" ٦X8_Ŷ?zͲ'IjW8TSdOelHHKyͫsIPc E K.[j垀$}#Nj2:VBMwt@E۪d I",t!?|mߍWn ڭ߭E({`WA2X&V>΃<L% &OE6"e>9soe<ζ[|/Vp,w4X%{d438IL/Z}28/;Xyv0Y Hp@ũm3"4Nc+{]ve8&|<~#Jf ,X[5I *`  2T&‹ϟgUs6? !I1lVڵVͽX?*J<;$NCE _H5LByBZ)9ҜeKKunr*)# 'P(b5)*Vcs8qveX`d5ORSl眽z #OVaB Rj,3i_9Ȑc86O>E^R{ if+Nώ>U[V-{O5|`[|X-W^,ٳg/Y"!f YiMN{_IJµsǏ߻5b8ߵ͗7?T$rE+̭:`)w/F뭪{6_Q5V~,5^H qZߪe Jl"xt:2WCD'_s0\B=\(^~oPɵe1\ Li@ "مEB%P2V4}zi`ڨkڨ*5֝^PQ Sb&]J" \ǽ=>_~f}&o??sx2Tr^y_;O\ibFɎTdo6 pPbgӞf4۷yŪDNo}zbdkTj\N{ gncQղt:((cժ 0:/84[ur2Ur@rm9;I_^l`^7~ps8ѯwV˸/ȷoF) 4ƋPdY$k+c?K,=* ~]Z`sV.(2 EDm`hh/[OVX!(PQ;wn~=&m^" UHOx*E(K!Jep^dߴo inʁO>.%Xx+׷ Ro0J:Lvww_xA{{{Je\Kx1ލp/Βx~6FDik܋ZOF/T`+d&2яrW/[o΃2*T1$ˀYY-ar@@V*/RVS9 AVAf!LrwE.J3(7*@ӺɓB҅TSQL L~ |{Q[uZͷ^{-3Doe{ V3_]WzQh3Q.CYs]e.b5J9d""z<v hج7cKzF˰reH Һ6ONƷDk;DSvnAd,B8 `f!IYο=PJ hiVNdRATM/LhŃw%N,,a!E*wkwwj||6cu$|U$- fH$ "'yZfTqY u+R|Qx?~rjJl!}A|c7euu4ܬ]d7 ftZȤxT*NNz=亮چ B$QhXl1K|pkweV []{_>F%ljIނŅ5P) z|~<_μ01 m/FYEJ Nqeibũq&k4dȑGilp^.4 4Qg4kqZ08T\ID@ -@]5f^4",k7"~Au9R ;| ΒTn5sQqCiUϣ"\eauK(!N\؃87G_QHŁԌj,4*;Y[I2 DJM-v>`0q{Z-՚aeGO׶gij랝l{"۲fyն_+l(wUB0Ӧ]c{yNB$Yp1GOYyƍ.GP/[v+r|j50bEee@T8e,ë{W`-4Nj8UT_<.7sI9PHBJeWvôZae)}ߺnadؿ}v^r3f! 1Jf}AU(VXƕϤBHl%>Yx~1w`\>xxXroJ.*<Óu. =K-E%TK/iI RV F4*P)f$M^rJc4/O$>x1pt/*B%Жm.+(2:غ_>G^dc;isVvH67܏Y=MONv,e`P*9R!l;>Y,oLfN:Uנf嫢4VJ49/~@Zcqz3L[)w N?z4? /x:; QjӇ$2xFdcXhZb]0øxxg͸KIJҭi& 7G+\E4joA @^؝rdo\)6++omuxq֨[v5 p*!MEձ MVQT2MSaVjiԶE`u!J RO!ZA=8ǯ^)jep6붛Ԉ41 +SAB´l|M"bU?iGz2|əfԫMnǠ6o>: Bѵd<2MR*caZZZ}%gksULOݝZbfñǯ:2p,# tL^oRF鈾>E@[ yT6J1Zt]]3 |DMd}#Dkn"9$' م.&խ9MMf~Y<۶$n5[J 41ئ'-,ˋ I iBT Zi&i*l=Xd QMUɅҌGEMRʼd1")}pU՘̦7aJ879v}';W-ì {p4O(/ / _A HoXV CTT~4[. /A& J:ѻ:`a(lj6i*D\t:?{E}:T*R$'+"X.~͹ޭ7 coooZqޕzMrejHxK#*M<Ўeνj6nSAQ"J6-o7Nž٭TlcGEXE+?^$ Yudbip*XsM?L(MRB@ۍŁ Yьd0088hZjuVGżV61$H0OlH+w%@m78fm~pS@@ 2CF܅Bf!;ǃ;걄\ (ERK,K)N@L_qS!Z''@~g^#HD00$ߨ\.W9szzh4.VIlE A.0b.b)@F=H`F888x 8LFqlQFm2T-i /|ْXFprks9ߡNK(& ӬzYGcmS<&eD-hT:!Q'((jnܹz>cnwr+[mGk:D 49PrtTS:Bfe4Z^җ.r(Xz59["/Nsqzǻk;xI8sĬOE$Q7?XH)PN kmD-""j93'픟\0U,Im^kwk7BP`soѿzl.x ,1$ 5V V))'8w8؝F 0ԏh WOPR ʥdl~UlfM6UmV7MjU*6FOwNAbV%$H$$0IpdL%Qlpa'Ilq1XꓣJ72_7l>r+%DW>;ac_x<{Gǵj%|a;i&cD 1^z<ң6M+.!Q+: h5]t{O?~ɓv+^6kԠr1:Nxu.xUת;w"XFG* w˽'K<֦aeSNQR2Ү\e62o_y+M!\mv=yv~|t!yQx5Z/,Ցנ)9%*Mյ;d1^z[aU:4*#)-ӟ߅܄CMITB=܂EE6V6dr jPjiJ4ө5, _w^/Ŋw[n\.N' v9M!78$IRsf1:L@H:4-r6ɦ5\9j)o/Z-GF׾uJ 亯޿X ZkOzfެWF`h6/6pga 姲cy%tey4hQWZ0ρ@ݨQ-[!Zq`$ݖ{ol A:2K02+TRѴ% b!T߼{Pb(xQB) Ni>HǜEՊN'ݹ*_E$@lԤ?xF1CC@FϞsי;[WLd%挗lH" Trm֡D"$E Gͯ@.J䊎PiKUyBm!c".àRON$`0*h|]suJ*CݑX.$U$]捌c998 z:HN[/ Nv2C@"L2Mo^k܇ә(̓ij\̹+]H;+%pJ~CHIR\k٭9R 5n 4S7ui%$&@VA$I~] DE1m4aμMO A*`ԑ&?,N`u>[}vej4}ׯOGVV/N;%q%yD-|JdȤ닜0P5噏Ca@91 v]ZIF͔d-a(eάL^Gqun]=bJݪSs-j$:%:,IJ+ZD|v j4-,h`WE*HMo8_fYtJ pz{^2Rx(9W|*)k IDFm1"0+R6 GFn&7u NLf؆&QpJiqdj"R?C}:6/pl㣟͍7? h4jZϟ?Vfs2|E:tuDהIB$$I[)3MoݰLk0xɵUf{Il&i-Gޛ[r%aUuэ` .I4tPd9BR8lVvmɔ Eh5IJht~߻[U?dFdbyKUnZQO(&).BG~ɧ%S5L&)hGg-Q T7gkڡ۞pavn8* GG 3?=l5? wB.yWcDI R_ȡ"`EHQK^y޽{z^ya&{xG*pg>}nBxK7f v@+:6ouθ'z",Vo^_xOPݵGn)LIsH W}}kJ1GvL&!_Ø(czV& ^؞_W>&د-O0f/؉=DE@J\{Gn8Y. T){6(}lҺ!(;c`+W~\\5{ZGlS1׸R.7u͑NTw~qqitΝn\HDL6?=h^Ta$0|0 W`npY͌&F位l._X f:M*Y+!QTpenl? YWWV;h$x/n4{a=4 RRye{a,M/։0P؊(2,HTdw{.#~BC|ҥK.{vvva _}_|qggj/'$_\u;z.'f|3H+: %!- 6V (Ns$IX)>`qF{/6pR5( ]qkljvbIC{<;/o]sg= /qCj㥹A8l[A෺le _s0[ !,! :)QNN jv+Y;=G A0! tyb' “*g(N.-X!a[q x{]"u 8' 8("m gPS6G\k jC4b6w…^|qwf(ʥrrzf¹f>"K(~6l:H~֗h`M\HwR0L':0Lsw3KDclىMkB6)t̒Au9(R>ȱ'܉\[>uvZZZ\,K@ F z~Hq(嘇[IYjBD9WS}~X _z/q0n(LpEB_;QXΜTC'Stur@ lNmUJ1+Qݐ񺈌%t{#"cBr_3>ڜ2aɩ AQ.;JП (OM~`0U*泸PCO@Q\jҔ$=T u+iL)`.Ǎh1? @H6BHz?(y~Rf?Z}: Lq:k]dT9DIe%8U3J%NuU !u3\X,eY6B r|`azfD9" !ϗP뭣{+w7SDž|n{ZGְIv.5)j~7b?(䲐t;;|n;f2A&a&nwű?G}%12.YY.]y&ͣK+<*F0,dc)F}[w׎;Ȧl.%Vgئ6י<ݚԠ' }^nbz3O$clqeŸ[%(8\DQy^691ꍽͣs:49E9a'h(]zd$3q¬;ߕ(l%BW:*\;߽K{MdgOs[ɩR;leBb"г@o~s(@c0^FÉ*0bj" r&Oqfq]fE j?ԣw6lX U Ky- U6WmM>-DjJ t!2~HtAvj~.Mμ~G*_VVNw)d/<:[{3w>, :w.?y2ABZxi|֯e{n g `cZw){n(E%+qBw?QkwWgA-E )X]v#&*eJ5D~y A ZZQ!i̢{;=_4FF3RF"ޢp+Ě"$R-*j3Y% 4w R#N96K@GT!n~;D|g=o+[KSL4DĘZSWG5JL3<ӏ9GȿbD?|Ƀfeh喠-4 'D%"msCB1IsO,/"F;䲙[{\& ˜n;)>(ocs.Z64raE DR26f{~JN@G#}9)p CH,Bj7E2iu$^jE[1rwx5svVP ?ب=}jjn5:˕EqG |.! dv\N J1LyU<K%SQ[M0 \H|s_F'l֪d4IZ 99[4B@k8QE?nՓU"yR=q40乹!!:s)S*qs@bYqӡUᣜT$">DjG^<f VHkjrI|:q &ZX|WSq\i$k/&DB Divvv8yMs`tf'3XGEA8;i#[&)ȑx;q3^]{R&Snޣ\#baF9?=JRݮכ+++3sqvUs"L}(̀h&Pī.qGsv?^E6?|RڝBi J3hnopq<vT N^JDHVf94ӥz2NDbs[bAma=60u~bFFS)gf5WMƎ@&@c)es^'|*ͳjUiK7,er5`#ZG2v%{&JfQ6 !5`KqW =oI&qĨxJǐcA.M$Lpr}\9ͼ~}dXVw3g^^33=j m(I- (6wAYlW(C*W6 =s-0Q\J\e贳OT 8]n:!N:la18lxRI)l^H؄yA (U:m$`l$ 6hF^*vgH ƅI (jW3/n` >$cP8G.]`XWZ~ {RNBP N~\ا0Z s+3NQ7Er[?E!`ЊL ڞ)ht+;D ɉm@NuD19H)QC8*9 ~LƴSw**,hξHLrv҇{H-U!e:DN2E 4t5kD$ϡJ;AN˨ϸvӘҕ5rkyjjlK q1PWk!op'c6'OLMh~Qx5ïT7V Lc?Iaq@RzTßLC*2n7"^#cSj@ BFtP ʷڱcMz1h/S::J,dd9Us3-CJbH*W׹H1.@1Qh`G)?r&0_ݪn&d \dkJ6CWJ 7k_Z 5 E<*i4I, ${Tq`W0,'6MNt%3]bpѽyE1#z=ӂMVc'ait٢&gD(qC ^R&0<"]0jY ̶W=@G5=(tF+_ ϵ!JFHD? Be5l |@IR!@O/w/>FDv[lb*lz7 'DK@̫?N&*ճ!ѮP4SIStlXS$'/ ṌrXfJ9yCD̓@h(E]ڡhP?'rfX;SwЬJX mh,d&66.2ǜ^qZ\+ q&ARjFv[ո@".sEps;qpQ~i%(UQbq7LVg8{pش,zgM236;w.3#>1l|ēsoo: l'!LwaxH_?.gL7(6 l@T>-BSj ݠhd\mpWM= ?VНTALZ#= 3 q0ʒN&,kF-f=A4{lrW;P㭣F!@ Ul|c%ʣ-ΐ1!).iIq@l4N,ZxIjqĺlef}2JG#A(,Wi0%UVw`NWVTw `J#OGĖ10z~o`HƯJmɐH22C1IhUITGvd.mC{$K 8%L19&C%Q"}֌<(Dw~K@"S"CɒWxZ!D0*M62:%hdm5*Vb}$feyUKLd̺&ўr9زHR4f#ZG$K;s((Lc}@1/.6kF1ak0nL*+"sHRg1đ.ZX )}U]JQ5"1RIN}ZcheU^WJ0$aB6n, ?`YR iO%{Bq0Q.ASb^=FevD˟nDSy5 35wj!J>i0#mTp}I(Q$t@xwK,vT 3c#AK Ǟ7'GT[KNrAD۟cWЉp1pY[MPtMzADBa-dIfv+ ͙B#T H<^Z4C0Li+;Ċ,oV FHtQ 2@xe>yJeKa`iRDz\]]#L&f3 t@JĹ FgXN$c PNoxic a:I_ ?Y8'g'xh=ac S8X .3Ċg1d2t ⶐSzӒ:"I(BR1D!SVQ{I>*3G cbWE K3uC@RZ*e=j#"ElUx;6-Қj.ЭY@d+]-~ŶVD)!]׸Zgo#ռ{ Lh? C#,M@ЕhUM9p> X -$GLH-Q@YUKe8#G!T*Lrn .k~Fi-31N,ޠ鷛懃n8A&p Bus3d;ލ+o/<{s21qݜ]\IoתӉjb[tK;Xc1F|2+D ЀC;afHDA|G D}_6WsmX 9%8̓.ۋڒG PtnL:K`_cL6gMdr沪'ΉCa&b*qb`d}ZSSTBKNP"`^B&Xӏ;sȻi'!Jy*ٚ=<^<ϋPT4ӇoOÉUjB1vr_.v;Cֵ\xև+es4U[UC6A{z>_"- a4sVemsڹT acɸ,dLNعk ƫtݤ~YN_{duacC5*e2~0Zy7q3X8$O`z"1;.䞌 1D97/t</GUF M¸azg&Kt *Ӌ1[P*dq~&Ug\cY%O!b촚S9fW`9{H!f'˜/h |W^=|"tFve}rb8ygoSWo,?qhNXlת/$.\ߺ;^'tGɚ0Ok5zǞ07m1yڇ*7Ej%Y "fY-),,I \)Hjٌ ojZGn]f^5k7d3&I8g9`d^y2 rP9 qV!İe몬UbݿO|{幥ӭ҉3{[{[bygsj֏Nֵ޻ǟik8n'\wRur( ^8 Vx[gzwQLKnGQujNL4v1 a8d(=K3DD1629#+aM B߆4ZY(!o9;s|.Ns?d?^;Kwk޵/x|SR'/V'̓`0tn6Gd3p{kýl6??;ѕ凞Jo~&%{`榸g'2cajEޓ@c+?2O!V4N'Gl3-b(b։j-fja xqhs[${D  8cf }k|qq+[wLJ7;3W?^]\=r%cDdsv3(ZT9ۺ{~m5o^}7_(ysĹ˯~wԋ~( nvv}M:f{o|gnEp֦f=v߆hC Q+㠍Щ!Ny7nX8?vܲ׫? #oIJݣr\^LLH~N{jvaeifda*7g|~xvy 03N?vP=RILf=0`@)"-| !Dy8nۤyG@n^SCJ]0]#\RY~ i!FE%dR9 MՌІJHEц).IҨƈ;&uTgV{NmcS~Dn`Z6&C|WJ|Vl$I#RqJ.sȤQ[Rw'zE)WJL%z(q1G)Wj8?dbDQT{zt] b9CGtV9cCAo+-M MLC=u6&s L #cCKGM5r{ORib##27咣8lq#>Ғ#%LSĢg8cGđ8ydǢ`(GSر:9OLq󎠙NXGAI Qz8JQS7(KH+\1&Yr\w SI]h9{SSF$7GM]#[{z:Ӌ_~բG&=]!eO}m=7]<"DCe;Sv&&YcejYdgY5v9nh-|y%?1=T%d!!*Z 8ڭ,"L0_rYcwx,Le:_'8DqL 7a|gjIrY"ysDQ,QNSBiJ0E&(|@"="GjEP8t^yY7$\0P(Nn.Ng j)`ǿGz"V7\*_xzrQ-DQ FT/0 `iJ ^% 6s1U 6<M*NkZJg_v7Zgw%g L~m8Nznlھ xB{488z$S|T#rH`dHܶPh)5hb84KDl돟)Ld/}XۇvCΞXï]E1e|~3g .ÿwk?y}>y/?zws~'W]'~Ců[ʏW7zxy6W-o\wgt@;S~VG[wG~KNW3m~3_d{lJxcf](i[5d{_Z(gU?SvGS+??ʽF;a}omOU2onNv7zGO߾Ѹk~틟yzݛ YY%r!;>,ogk[ݫwZ{ǃO];cW,vf'_<k$"׽GO }̅Yhv{~|.}Xb/ "YSKv z{"&J ,]O Bgۑ$B5V/@:at??6.ѿ0ssl[)gֶ:o_o矞>\ǫo^> &A·ݵGO?y ?{^FޭaX{q`Nows ׎?瞞nuKs_X|[;A&p?1 juï|{ԉJkv'<69^䅘jiBԺ=-x3*(_ueD8l _~{'UFi_L# [?K27g 4/-~k~ձ^FG>LO V8Yd%SkB LEqlb9sBez Y(dN>/ {;7\q.p].ޯ_>xF'fr@[%LB%)KOM^Q*q+hiH0@r!hv"NUg.煥$|fIIڟ'[bvDYt[r*klkF0Jg+r+5߃avrџ( pm+?\J5 /{~_o7-G>n$Ҹq.ݺf͝]bwv4г3㿸7W֚fJ85#׶e&pqbn,BWR3%Ks3_{&=|~-V7yB71]>~ٿOמt⃵œ%0v/zl065ᾇżک_xfj1aW77; Sϔo^\d9Gr!(}o~VoVa9D^M$׾o7~#J߻# -Q W ˮDtOw"SO 6lHo`%F{{W77_`Ib^Սgs d9{ԟ"Ѡ_G'秲Atf8 F'f`_o ٌ~<3I?V 9bvӹZO/9>?])4;L5;GJf6hwDnmv=Jy~*vz'v8k|> rs_βI؊ImCʸ RCF8s+Lэm:Hꢧcg[g$t8'5iʠ :ΐHFa]aFL4b>|a *,>c?2/:c#oFB@uMЪhǢp8`UtYr-}P8fCfHhZIfx EZ$œaJR>iȸl9뻭SbWK/=y˗??W}߿kғo}_KK O1м;Q`%[rjo(NXTU`KNbĩs;K$a:A; =؅?7a"kpzFok}[vz][}{k0_yV_}J7>zwQtHىH <T[uAQ:\<)n]ەCWK˞@!ctEnttFu;@54OQln.#6qCܛYrbU_====7 dHkx^o؎B6jA@ `f0gLwO_wᆱ*#_e}U݄Q1*2+ھZ` 6Ә;~f6 Zff \[;Dg4ebU1"!٤XYx4M~G`8yRA2N(jycYdPBcg`-Pv`.A?TbǬ8 X +S=N05?Y9ݰ@0AqJB8 Wd hh( pH!;̎~ZA/aڡL-e91MP&mAsEV Ǡ1@$&Hc`Ҁb-=۷ 1H~`s} +mX &%Ff, 2 lz)9LFNkPdXlxCDQ{Ù3*B#c'MJóg!Hu]BNt]C]1iBa4׃Bnͯ1uX!4-(@*d#a8Ц^;S+v+^)Vơ ) 00~&Lh )l(L`8j+f‡Y>c&$zlۇIo0s8i fjۏ"6FZ~$A!>,4VB %XD [_oԕ~BHT۸pa$'h42Bϯ&鑑@t:"NCc>x,X"A͚М0! q#Q,9Y Z +ڀ!r@kkP3iDۭ(`,LDF%9 X1 L : 1"Ҹ'$XS"6'@*L J<nj` nqN(IexA.x Tp&4hrvs  ιQء 5z Ylzb~(0uʤX~1K08>/Ao n*w3h enr&p F# ɕ &.,#D 1Α|]A&_H\"ZXaXA<L`갰c*n H[b 9|k-UBFm/@OB4(D`fDAi #ءN*:(pyɔ:43ŴYeX1(6!iJ%M& 'o/ܺL$鄠_r޽B0aLE Dob4k*"HSNؠN[М`0M{0 m ,,)abPIX4S Д#26Saڷ懞 L d (X>Lbz NM2 \d8(03HZĈdM $&@枡1w  M_1sga` H$$asGV"J\uf2FEQ_4lRZ:8&ѴIKǀ2;P`ˬbgqڼS @$8x%25AO0#25;:=S ]i]_ .ႁ%`A [л#Ed sO@&:/Yj, Po ,R"io/@"I GV+\4~"B}Mӓ|弢w.v!@|$p4Y  Q@ayS̩; R4HчQ†`H69Q Z Ѐib+Ԉ[kW6b-F^[Ui{SȗE>, [ ӈ0c>Ȃ$aE| M6r;EP O (nuƢ9 #*f}`DfKod``X\  Z H0DC pSt0Xc~ `,kEL5?/h!t(!ů~ݻWNd2h4;:?o~:B\ŎR%wt762!D?}66~υ cۇxc\΍Z( @P5 Z,ICB"CC &/YĸF}"Rr:Ǐ'kkk{Z"j@(Vǟ){eYY]܅B!25544m8!40 `6:1&kjU06嚪A,])ƦLVTuL9x cca]`߭ó i12@<rGʮ opED¥6f-`? /_o0!$᠓pzD!9a s#L_Pt-Q01`XS  t B۔XB`ɚlJ(4^xn2/;Fs 2omc>ޔޚ(fkhdI6=zB$^8G ]`mfO-1&S6yd\`SlL`-q2| ӭs3˅ ,M3Wσerf(L#d+^H9E:>wʿ7w tXs-Z'<>m 8(6V}ֱ)زRE X9ȉj51&,eLD!~= NtqcskgJ5¹pyr/^:>3o N̳pgwvXXjXe;1TN`7P/ff8ֹ pfaj[I[ UAi ;i5 Sz \…a$hЅ>CSeІ,v.&m)06XwAA)2.3x-,\y2/ړ'?Wg3w4Rkg}shTQetH++k!㭗bN^r(\ȧ v1~L }uCP[;]@.07k(%l{ߐ*"\0ա=M\$papHH@@*A (HyL@ 437:y~X0[ 0b4#swǥE+u-P]֛߫3W[|c2֥Xwj'a|lLs#=FufTkgC\S_wa4pq,vcelcex1 PY@ V7`r01o7Љ4nH>t JЀAbN351j㈉ܲѨI&퐒 f&%fiwh?ۻܛl RLW`3y7o(B30? :1|aO"k윂ˤ@|$H +USFB~B6aá* m cMS׈-ȢkTvyUD'<1O),⭚tSFF! 3l"O9iBX\k9dh=}O /(0?@ '$lc81Jx,.AdN]Q0d3M}Ll/(Aar`0O2n FP.L;S}><N۳u JشAm1I0D %,.6>qp#q o7jpDY1,jL /C  O!d330Yxc0 (afPD3f?<K;Ոqm`(41.=&F3m'.6PnjY81c/도j[k,@[^dj'~VZ5szSZ4;kpRRbCfy ~ VrA^ W-B!JĠ6+p  ~ւM̳q ,| & *M”Mㄊ)п-R>50J@gH!qjYpy11,,hM0AM )r5!ĭ,\о0bd4'N&|Fw2 ؖ_)B*dY:B0Y[hbeI" ܜ$]%_a)I5IsŠzAM6Fn˔V%V`!hjn 665ẁI%dעMBRaXIUϞ%ALP>DmljT*N+z*M~A!Tֿ2GGJ*ʇrz|\o BUKXM\&$ 1jcs d(#"IBXJN܄7\ WkeY ̦+等 YQ'7|\& ALxn䴦T !6=#ʎYcB5'SP 9¶JFMñŭ3F޽%qPܚ)+ j1==Nݧ##===QY{{;TUx\rb!YUUsJ[-|gѳ!fdLTs`.`̐(Ь` p+@2;\ccd(|b&N2\fA=P&aBG^L#g?ly Xd >6QH4¥2Q#h_$yX@llwbg'Y5UUusR sttuEBo^cc} cϗBP{L@d쬖E2S4 1A+Anmtb oV"U0Ju籰Vxem%,p M3X@f\ mc4S>`$%ً=3x/dYʄ>a\1l8*T<37cbDD-lp*bM8i`F!ПICd`l`d# 2s c'Fdۈ a8\cU% }L @ٍp؃0m t~@fÜa 3 * q lM̯ .X;0X1$b1~d ?] G`4Gp@8A3Y" 4 2L0PBrIހ 0\ ʲbXvC8u$4$ M pH'p"2ԟK]-fR3Ygs9E2Ox`Ҿ~Rtkj Η[%؟ Ed Gv/`&6 A?,yg!osHi=f jԄ\@*AG?*Š Aʗ[}gsy$Q)9H[Vfh`nTojݞLFIH}㹎avy}:Q-oW f^ojŊP"h7Y6w~yˑ'4PB0̀eȱTp2US,=a4(;/ߟ7zj j?{rw^k#iF[=~<; FZީ`U t 'y ?`W !f@+г@X ]'UGa\ #!F[ϽBدKΰczmD]O7ˊ,$2AІꕚ`rH*uKUr3Iouoo׸? jD0Sylǟ%5Mx~`!t)hlG{F>eq/K:ʕZf_ !Tu DXQKU0Fa~U0Vd\i hpu&#7SծϞigTy\ly\R0&"#Xqdl6ilVXn$~~hBVOF{0#\`$v+ UM'rMB@gƭUm\^\QYr٩/) En4_7FFԍa"Io/&V;;lmf!H: "BU!k"6SB|!OTl, Ւ3Lgg'!diiixxV[)zcccllP(B-әGGGΞ=vX*r8~ٳP!4\Hؘc{[nZ(А"I& GGZw\}q.---OS{{]GD)H0(﫭F}54R0(mnT*NUUKٳg܄'`!C՚bhPi|L*^0T(4vwwϞ=+Բ-F!$II kV~?!$Ra؟s(!=5p@lr4 04!>~0dJR ===W\ⶋ`9qήUd:> u!ۛ<@';dX%̝lEt:(PgϞB1/^GGGH$nll$F +J>r.;nmm yΜ9S.;;;?~<55Ev3BlNMM=|PUUF JP*noVFf~xe2ÁQ^'2q88=Id-²t4doOdRQMRd2z.r"tvvyn+Iኢ(;;;r`rrrD"Q#H\.Jltp8<00N%FE;w`ww7H|p8L}ն>V bXX,VV:!tr9EQ!FcttҼ?88j<F%h;嚎33F9wl ,oVXd>l"yI5-ce||< aϜ9($I===~t]w8OMO;vw^%Nt"Y^t| *i$d{<j)K\;;^XiP`PJ8U~ !k _W7Nfg+FZƜNBJB|x(`&&&Q(Frr<υHK,Jl}fCa&ʍM0mOdFfF©nZ=zV_|߫\jXP򯷯PEGtJFQV#'li/+#SO61{-3fɶ'fѕ?d Ykx"N$>-2!KuF/hGݗdi |gMSᬌdPQ&[ !H Azl,pw%;xk[QTH|`ڢ>}8Uz*UqVA eÑZ _FA}4qa@CFL@X[D].7kV";TPg^(4TU}wWWW1hͮ?S~ t4??rn߾ B7o\]]u\}JzwܩVO>CG ʲ1,wi4 lo!bTmg 0bbepnnBF/:UM ] N`UXT֍RIBv#VVVK4Hd@5NB^0B. )e zŅ̧y0 6ni>A=f؀`BsB B#ӟ~488hh[z4___ۣ$˗/{]]]}}}+++$ ~SSStocc!Y'&&^fflvhh?ַu޽ahw-.V] : 62r8ILNz hoydĝNfgJ*rPHpN2Ázzzz}{ϟSUR,..6 ñ6==]* /@4_timm-HF"ZF7^o8~E"p8|Eg27|g?t6Z-AzYUU1Ɓ@@W^y%['t ۓBg622R*WWW_{~wO?a}]wppp07633sx<DRǏ{{{ekBGqR懖>2!2We~2_|83n? !3L4} ƸRZ-o|d{޹F}^;/>}͛t\.B~t:]T4M[__7R >t~A rIѨ2>n6Ȉ;VWVGG͎O*aOi J7n^IQp-,TQtJZ">|'$yx𠣣X,\`0믧RW_}uppT*&x<~Y *ЍDPi;!4==zkZWWM&PӧOkםNٳg=C!twwe(ofXbGGGi!ٳٳgKbvOMצں?d2' 02X6Ԣ#>rhzwX]]|7R) ʲ2erZV.V###|v7VDrԔRZ-EQdYVp8E"lYt< /<|XP>yRE2$ZՃA^uݘV* .ԥF(t?'BAsz]w$BHA^ĪJMi$TZ-?.] ΩJF4ucv1ƺTD^n> `MT,i LTnj!ƣdF/Wh4JҺ\.EQ^>,4pi-ׄp/Ll5R ,S fYTx<\,7 ǃH| WEzzG*pXuUU%Ir\JQ-Baws#C{1Sq",½dQX±A_'qn)XB ^o-fH4xa"6gXܳ%|̴vQHA˥\^*ǡ>[<>>>D"|> -,,?l fgg3L(J&X  NMM6Mt: BOOO:<ϥKIBVӗa%c1IQ I:ˆMC4AI2*Y_ojl`bN;:;[[[ކBhg=8X[]JZ랞fnJxSPHUr/ issKi*b>}zViMO@ŋ-TthabUIoś\,E)JxQUUUUϷtzT*gccc>OeJ l14ob)(UDcd'1s21!vvѣŁqG"><<, t TUBꫯ;\.ɓ|;kooJ4~iLRtuu333r9]tJbr&wu>r@@*uYF^.LFsەIXN;*)v:BQHB߯Bj__Te!400L&{O>dppP(4t:H$www/^ά@3MSXv_ӧb[.|LWWBc} @ƙp8Y__ؐ$BJ\. 6\YY!$IE9>>P.z02>{EÄl6KK$tehh^jNu'FuF)G/oi% yBzib;l,-Za1f^*`0AJ𰷷 SL&C5$@[#j&*@cժh/{m;1Q%Ö=W8 (P'qAZu:ќ"tv2C:99)$SN S)7HY`˹N2ogg-~xeb+42C%0Ge0MhEDPC!B~J-r I:aq;O\c+,!vG(T$_߄F`7y? 1ZVe> @dc)"$mob]E"01^;:0p㉠cT*;ܤ\.CbjTUϋ rp(L6Ri|ZU*55m5::jXZʑ;zDau;;j۟ T*ӡAPPVaJ8$zBS ;; +Kt[bli+v775H9N 0uEe&N\fu#h]ZZRzQ,t^_ =|PӴw}^R@ ;οzG}f?DǏ?{,L>z(Ly!DOJD QioXkzH2{gP muxwud<^±Ō,䙮bocᇛ_O&+NBL޼9{޽fIܹsgyy?|2Bh+J~{{{{ggÇx LV*G}l6Ǎ7?~h4o6 6H$GAj5E̬ ߸qV{9L&#IO~]{zz~ӟnll\.??rյT,Z6ݣ BzY[nፍt:}= ZJzs3]ܹ3>>~mBiQk׮hV[NgvhbXT*o'|255E߭өNy:eYju` Gn޼[^^Otk{{7ϙ~_looj.~ibbbyyymmMUt:x^z饷~{R|>_y񾾾D"ۻi$!7g[VߟK$έV._Lx;*;sS\nhhΝ;VҥKj7HVUzt^`ӧX,vƍd2K/ݹsgggܹs xc<33CyA2xq۴rtB9aQg>pqdό"F!c3Pt1(bP ###>obb"|;ߡeEQ% z^I=zD$FH$rk~񩩩z^V{5!*Zl6_~xx/SIX,==By<@MaAᐇC^W{{nrx؞ls` o4FC|Wu24TZjZV[t޸1x=z499D˗'&&dYNR###gΜ ?zzzn?X*5E9>>BNSP(=zixp0Hzz޺uܹsd2ぁp8rJOOtttszII$2zWPh#px|~>BGr?X*QQzXܓ$Bxkڍ7.^/41(dV.'!TٹiyDAǀ,c$n 6RMb$.ܷ{P-eSNf5mUvx"uj93khj5o BMpM4(gl)IZPPfl~z^vC-X5B,舩ڟ8b](UU'PA&+ sҞ3e\. fx~n"qg 3x"'{8n?m6ߪyL!^oVs|Baff& ޺uhϥUIn߾MN:v8KKKM󁁁E׻_[[d2D"A_I&Tjsssgg~w}yi z].RI X3g:<>v8z.TRINN;j\,r:Bh~(գQ!Q1?l,'ObQǵwWVVjZ.K$drooommmttc\,:}ɓ't8~(޹sp8}>B?w:D"qttvk6;w>~8oݿvkI:::ݻWV1ܜO߿Hj܏oTu˵M[[[>`xxxyyYbh4W`E#{fs}}=P7( #P߿G@a2[[[\uM|@ ii`0ph~ 8w_0 BZ^A\Vvw٬PP|>\1FRȻ|^RI>8p9ܹZRLTT*:evgEJN\&N'.3m49ݑrtzff&xޱT*ET,--UL&?~Fwww+KKKr!s~> smllz|| UST*~GGG__~"#zVǷ!Y *r9]i%Bhoo^BTUJP(DY-Z-H z٤_p:R !Dgq?6-KR޼yҹg g9!::z kkkX,LR2 B54D"GGG2\.^wwbJ=ioɕU==[YYh{םwNT4 %Q|n-R^д&*?RVBN*<T>_-'j a'$# 9P*h`2H˿ŲYŏ@c` Qօ :7!4s(=:j"( #sHکG޳ҝ;Vf0L'k.,HU}v\C9?l|^ODG'6ѨdNTRQ0=[d9NòL(HcfqqtaanvAZ`]Asw6t6~.b6QW'!kMӸdeEd!l`4`-F+NA>1*\kqb&P.NE?E) Ҝ#w0$ gC(F&"A(Bܑ`Zٳb)c0iѣGdXբOD7^w||wV*'O8p8|ttTT իX,v/..v,CH$PJa,|q&r^ Bk-&un J&+FsHtPhi4 QJ1VkK1 H:~Cf*r쬶ݻݮ2''ENGJZaa+++O<(y ׯ)ϟ#7ӧOfɫJ (٪lnmm!ǫW޽j?8X, *V$Aab^x9fQBNR@ٳg\nrroV`\Tj5TMV;>>(ZTw{%q~m>G8W#G ʘ替rw||LQԫWJe6=<}*vSN:0py`\BB_nT*6- A0JOKdyBB0:IQ#ɨp'lhL@RzA>Dnw0 ˡPE666vww777.KTz6:ikcc޽{wbbT* _W;;;&)LS:7jɜ9<. [-f&' zY6iD"~x::2 5zj /4:tss/ݻw20r7y/fz*aAj5˲(eُ?lrwxxH4څ m՚Jle硤~d2 Y١Fòa\|1:!hJ%8D"q}}ME1 cW);noP RI(pd䎚LVGL6`܌F.kyyyvvr|g4M QEQw8N<`6|C//--!)EQ<xÇ~H$BPYYYAG EK77J.fӹ\FHZISnl4MkL&gVX25ū=/ӦөhT**<̓^lO~FC۷MRs׍Zѣe2 @ \._>liid2fRkjukk@=}'_,JӴ^gRdޕu)j@bx̹:?l;-J#Kz!v)->W&{+0iEQ?$+Eq)S9<{ewwwrr󽟌ϟCK}ٿ/4_GK/4YG&rH ÓL zmΕe3㩧] L)x|wST[i: $݋8'THx8 N_@IpXt"AV1}#GH)ձߙ$I;y̫ 𚇳 % z QI0wDި`/wiC?!HԤp+;dm i$D$ N}M2Hn3Mi Hg0uGФ;D4hĞ4vH|#JɀҞ q(e ǐd-&? 7Q(p#iHf hp, @(F#1$&@28lW`r3f uH6Akvb2H eN9DHht]\\— N*"[JȁT&P_2Lf~k cR# SrW$'&R 4Mv(ĉn6Gd[}WGrdx%l] w0/3vGlb FIQPrʅBᏏv?}z@ƣia j Q[NݍFӇ1 ȶZnNERy YFӍF+0 ^=;ZX(vsS6|5;;vɫYg^}w7nwNCLpvt_E;w޾FӅB5kX&w:B,Ḏf OM9^>K&s(oh4ժF۷d>_xl4Vk]͆sMh Z^pZMTX)tkc*RjCzBAe2rnL@<5Ѩzi郃d2W(NO/+?.-͔J̛7zhZTF&RDJE<~kbNB!Bn,#'H|wbPAU }%n*P6H%@,jm"uU#g';iHjsZ IӅmo"+ rixE%#>pE~a*"ȹ\V-䤕aZ~d2(2nw *Iw5UMO;YU7u:-Mj5wUJiu:Z:9Н^)l\XV6Yjs ɉ }0VXy޼NNZzmvV+ffV(BAneBR&YZ9=|6lrv;Ͳ-դV+ jm-psSXRqrכ6bvzm6^h4tZܙB06Wfg]f{ii&Vf!,/X\6QBufhp fe[fqbBqJrYN MN 2LSt$ܜGRv:]^{P*jJR RN͛sffh\,j6I[縎N/,Ll(lj4&X(f2;ཅT\OBX@<wUVHa_>2..罷K_\(P:Q=X}TQyԟ!JRIGOqX]h40mDRvy}}Śxdk}}>D&uqu F߿rYk5f3U*cX8|kU*%@Uj,M) +&Anw8h$Z5 C_]~_*\eu՟WN 0@2G:034$0AD4GZ\Bu$M9Z#mOQRAʎiʪc;=Kx/ 1lRV0 #I'qU 'jJьbRu~TJь^eV4nׁJd2qO?]ߏκ4U*2Vܜ7TEBdl6Y;|a77X-4m4M>Z(@Ԅ}>l(`A։9O4Tz]__XXQ#33n-͔Ju$-3L3M3L+|^m4R!t~_2!&JET*S1;xIDF[l+͐pQ V\%G aѵHrmyd'1{;d+RET"$#t S%7)d]NNL{VPO]]u$I޽yY l6y)vyZYBM A\.WA޽@m4+榤өՆJbnw?l\fwvg|>n+*;;;yy* FtҢ>( zT.3\Wlߟrl&בUff&u:M 6Z' wٲNq:-f~rҊ>3r8hĄ>)xif^QUd^g(i:Vr8h1No'E<l@Hi {aD1+HyP> endobj 159 0 obj << /Length 16380 >> stream q 15.000 32.472 577.500 744.528 re W n 0.965 0.965 0.965 rg 26.250 679.968 555.000 97.032 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 679.968 m 581.250 679.968 l 581.250 680.718 l 26.250 680.718 l f q 35.250 691.218 537.000 85.782 re W n 0.271 0.267 0.267 rg BT 35.250 767.476 Td /F4 9.8 Tf [(Fig. 1: Temporal and geographic distribution of S-OIV oseltamivir-resistant neuraminidase sequences.)] TJ ET BT 35.250 748.106 Td /F1 9.8 Tf [(By clicking on the Washington state marker, we can see the date of collection of each of the two sequences represented by )] TJ ET BT 35.250 734.370 Td /F1 9.8 Tf [(it.)] TJ ET Q BT 26.250 662.944 Td /F1 9.8 Tf [(Selecting one of the latest S-OIV sequence with oseltamivir resistance as our reference sequence, A/Washington/28/2009, we )] TJ ET BT 26.250 651.039 Td /F1 9.8 Tf [(show the polymorphic site distribution against a subset of all oseltamivir resistant sequences \(Figure 2\). The two bars along the )] TJ ET BT 26.250 639.135 Td /F1 9.8 Tf [(top of the amino acid sequence show whether the character in our query sequence is unique, a minority, a majority or )] TJ ET BT 26.250 627.230 Td /F1 9.8 Tf [(conserved in either the selected subset \(lower bar\) or all other sequences \(upper bar\). Most of the minority characters in our )] TJ ET BT 26.250 615.325 Td /F1 9.8 Tf [(query sequence line up in both sets, with no indication that the character is related to the metadata values selected for the set. )] TJ ET BT 26.250 603.420 Td /F1 9.8 Tf [(A single site shows a rare polymorphism in the background set that is conserved in the oseltamivir resistant set, residue Y275 )] TJ ET BT 26.250 591.516 Td /F1 9.8 Tf [(\(Y274 in N2 numbering\) \(Figure 2\). The presence of a tyrosine residue at this site is known to confer resistance to oseltamivir.)] TJ ET 0.965 0.965 0.965 rg 26.250 276.757 555.000 304.877 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 581.635 m 581.250 581.635 l 581.250 580.885 l 26.250 580.885 l f 26.250 276.757 m 581.250 276.757 l 581.250 277.507 l 26.250 277.507 l f q 205.500 0 0 225.000 35.250 346.885 cm /I12 Do Q q 35.250 288.007 537.000 52.877 re W n 0.271 0.267 0.267 rg BT 35.250 331.361 Td /F4 9.8 Tf [(Fig. 2: Polymorphic sites of the amino acid sequence of A/Washington/28/2009.)] TJ ET BT 35.250 311.991 Td /F1 9.8 Tf [(The lower bar represents the subset and upper bar represents all other sequences. Position Y275, already known to confer )] TJ ET BT 35.250 298.255 Td /F1 9.8 Tf [(resistance to oseltamivir, is highlighted by a conserved subset site versus a rare polymorphism in all other sequences.)] TJ ET Q BT 26.250 259.734 Td /F1 9.8 Tf [(Although the most interesting residues are those conserved in one set and a minority or unique in the other, two other sites )] TJ ET BT 26.250 247.829 Td /F1 9.8 Tf [(show a minority residue in the oseltamivir-resistant subset that is in the majority of all other sequences, residue R173. This )] TJ ET BT 26.250 235.924 Td /F1 9.8 Tf [(residue is present in only 5/260 \(1.9%\) of oseltamivir-resistant sequences, versus 1176/2339 \(50.2%\) of all other sequences. By )] TJ ET BT 26.250 224.019 Td /F1 9.8 Tf [(clicking on the amino acid character for the 5 oseltamivir-resistant R173 sequences, we see that they are all part of the S-OIV )] TJ ET BT 26.250 212.115 Td /F1 9.8 Tf [(outbreak. This indicates that the S-OIV outbreak may have the first examples of R173 in oseltamivir-resistant sequences. By )] TJ ET BT 26.250 200.210 Td /F1 9.8 Tf [(changing the subset to S-OIV, we can see that R173 is completely conserved in S-OIV sequences, and not likely related to )] TJ ET BT 26.250 188.305 Td /F1 9.8 Tf [(oseltamivir resistance at all, but rather related due to coalescence.)] TJ ET BT 26.250 168.900 Td /F1 9.8 Tf [(Site G249 is present in 13/274 \(4.7%\) of oseltamivir-resistant sequences, but is present in 2089/2582 \(80.9%\) of all other )] TJ ET BT 26.250 156.996 Td /F1 9.8 Tf [(sequences. G249 is present in all S-OIV sequences, and has been seen before in oseltamivir resistant strains in the US in )] TJ ET BT 26.250 145.091 Td /F1 9.8 Tf [(2006, and the US and Japan in 2007. However, K249 is present in the other 261/274 \(95.3%\) oseltamivir-resistant sequences, )] TJ ET BT 26.250 133.186 Td /F1 9.8 Tf [(but only in 440/2582 \(17.0%\) of other sequences. It may be interesting to track if a G249K mutation increases fitness in S-OIV )] TJ ET BT 26.250 121.281 Td /F1 9.8 Tf [(oseltamivir-resistant sequences.)] TJ ET BT 26.250 101.877 Td /F4 9.8 Tf [(Example: Tracking the K136 residue)] TJ ET BT 26.250 82.472 Td /F1 9.8 Tf [(Recently, NA K136 has been linked to zanamivir resistance )] TJ ET 0.267 0.267 0.267 rg BT 284.732 82.472 Td /F1 9.8 Tf [([4])] TJ ET 0.271 0.267 0.267 rg BT 295.574 82.472 Td /F1 9.8 Tf [( . By selecting this residue, we can view the temporal and )] TJ ET BT 26.250 70.567 Td /F1 9.8 Tf [(geographic distribution of this important mutation \(Figure 3\). This residue is present in 11 neuraminidase sequences available in )] TJ ET BT 26.250 58.662 Td /F1 9.8 Tf [(GenBank. None of the 11 sequences is part of the S-OIV pandemic. The earliest sequence with this mutation is from 30 May )] TJ ET BT 26.250 46.758 Td /F1 9.8 Tf [(2006, from the Philippines. It has been present in 4 sequences in 2006, 3 in 2007 and 4 in 2008. It has not yet been )] TJ ET Q q 15.000 32.472 577.500 744.528 re W n 0.965 0.965 0.965 rg 26.250 679.968 555.000 97.032 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 679.968 m 581.250 679.968 l 581.250 680.718 l 26.250 680.718 l f q 35.250 691.218 537.000 85.782 re W n 0.271 0.267 0.267 rg BT 35.250 767.476 Td /F4 9.8 Tf [(Fig. 1: Temporal and geographic distribution of S-OIV oseltamivir-resistant neuraminidase sequences.)] TJ ET BT 35.250 748.106 Td /F1 9.8 Tf [(By clicking on the Washington state marker, we can see the date of collection of each of the two sequences represented by )] TJ ET BT 35.250 734.370 Td /F1 9.8 Tf [(it.)] TJ ET Q BT 26.250 662.944 Td /F1 9.8 Tf [(Selecting one of the latest S-OIV sequence with oseltamivir resistance as our reference sequence, A/Washington/28/2009, we )] TJ ET BT 26.250 651.039 Td /F1 9.8 Tf [(show the polymorphic site distribution against a subset of all oseltamivir resistant sequences \(Figure 2\). The two bars along the )] TJ ET BT 26.250 639.135 Td /F1 9.8 Tf [(top of the amino acid sequence show whether the character in our query sequence is unique, a minority, a majority or )] TJ ET BT 26.250 627.230 Td /F1 9.8 Tf [(conserved in either the selected subset \(lower bar\) or all other sequences \(upper bar\). Most of the minority characters in our )] TJ ET BT 26.250 615.325 Td /F1 9.8 Tf [(query sequence line up in both sets, with no indication that the character is related to the metadata values selected for the set. )] TJ ET BT 26.250 603.420 Td /F1 9.8 Tf [(A single site shows a rare polymorphism in the background set that is conserved in the oseltamivir resistant set, residue Y275 )] TJ ET BT 26.250 591.516 Td /F1 9.8 Tf [(\(Y274 in N2 numbering\) \(Figure 2\). The presence of a tyrosine residue at this site is known to confer resistance to oseltamivir.)] TJ ET 0.965 0.965 0.965 rg 26.250 276.757 555.000 304.877 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 581.635 m 581.250 581.635 l 581.250 580.885 l 26.250 580.885 l f 26.250 276.757 m 581.250 276.757 l 581.250 277.507 l 26.250 277.507 l f q 205.500 0 0 225.000 35.250 346.885 cm /I14 Do Q q 35.250 288.007 537.000 52.877 re W n 0.271 0.267 0.267 rg BT 35.250 331.361 Td /F4 9.8 Tf [(Fig. 2: Polymorphic sites of the amino acid sequence of A/Washington/28/2009.)] TJ ET BT 35.250 311.991 Td /F1 9.8 Tf [(The lower bar represents the subset and upper bar represents all other sequences. Position Y275, already known to confer )] TJ ET BT 35.250 298.255 Td /F1 9.8 Tf [(resistance to oseltamivir, is highlighted by a conserved subset site versus a rare polymorphism in all other sequences.)] TJ ET Q BT 26.250 259.734 Td /F1 9.8 Tf [(Although the most interesting residues are those conserved in one set and a minority or unique in the other, two other sites )] TJ ET BT 26.250 247.829 Td /F1 9.8 Tf [(show a minority residue in the oseltamivir-resistant subset that is in the majority of all other sequences, residue R173. This )] TJ ET BT 26.250 235.924 Td /F1 9.8 Tf [(residue is present in only 5/260 \(1.9%\) of oseltamivir-resistant sequences, versus 1176/2339 \(50.2%\) of all other sequences. By )] TJ ET BT 26.250 224.019 Td /F1 9.8 Tf [(clicking on the amino acid character for the 5 oseltamivir-resistant R173 sequences, we see that they are all part of the S-OIV )] TJ ET BT 26.250 212.115 Td /F1 9.8 Tf [(outbreak. This indicates that the S-OIV outbreak may have the first examples of R173 in oseltamivir-resistant sequences. By )] TJ ET BT 26.250 200.210 Td /F1 9.8 Tf [(changing the subset to S-OIV, we can see that R173 is completely conserved in S-OIV sequences, and not likely related to )] TJ ET BT 26.250 188.305 Td /F1 9.8 Tf [(oseltamivir resistance at all, but rather related due to coalescence.)] TJ ET BT 26.250 168.900 Td /F1 9.8 Tf [(Site G249 is present in 13/274 \(4.7%\) of oseltamivir-resistant sequences, but is present in 2089/2582 \(80.9%\) of all other )] TJ ET BT 26.250 156.996 Td /F1 9.8 Tf [(sequences. G249 is present in all S-OIV sequences, and has been seen before in oseltamivir resistant strains in the US in )] TJ ET BT 26.250 145.091 Td /F1 9.8 Tf [(2006, and the US and Japan in 2007. However, K249 is present in the other 261/274 \(95.3%\) oseltamivir-resistant sequences, )] TJ ET BT 26.250 133.186 Td /F1 9.8 Tf [(but only in 440/2582 \(17.0%\) of other sequences. It may be interesting to track if a G249K mutation increases fitness in S-OIV )] TJ ET BT 26.250 121.281 Td /F1 9.8 Tf [(oseltamivir-resistant sequences.)] TJ ET BT 26.250 101.877 Td /F4 9.8 Tf [(Example: Tracking the K136 residue)] TJ ET BT 26.250 82.472 Td /F1 9.8 Tf [(Recently, NA K136 has been linked to zanamivir resistance )] TJ ET 0.267 0.267 0.267 rg BT 284.732 82.472 Td /F1 9.8 Tf [([4])] TJ ET 0.271 0.267 0.267 rg BT 295.574 82.472 Td /F1 9.8 Tf [( . By selecting this residue, we can view the temporal and )] TJ ET BT 26.250 70.567 Td /F1 9.8 Tf [(geographic distribution of this important mutation \(Figure 3\). This residue is present in 11 neuraminidase sequences available in )] TJ ET BT 26.250 58.662 Td /F1 9.8 Tf [(GenBank. None of the 11 sequences is part of the S-OIV pandemic. The earliest sequence with this mutation is from 30 May )] TJ ET BT 26.250 46.758 Td /F1 9.8 Tf [(2006, from the Philippines. It has been present in 4 sequences in 2006, 3 in 2007 and 4 in 2008. It has not yet been )] TJ ET Q q 15.000 32.472 577.500 744.528 re W n 0.965 0.965 0.965 rg 26.250 679.968 555.000 97.032 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 679.968 m 581.250 679.968 l 581.250 680.718 l 26.250 680.718 l f q 35.250 691.218 537.000 85.782 re W n 0.271 0.267 0.267 rg BT 35.250 767.476 Td /F4 9.8 Tf [(Fig. 1: Temporal and geographic distribution of S-OIV oseltamivir-resistant neuraminidase sequences.)] TJ ET BT 35.250 748.106 Td /F1 9.8 Tf [(By clicking on the Washington state marker, we can see the date of collection of each of the two sequences represented by )] TJ ET BT 35.250 734.370 Td /F1 9.8 Tf [(it.)] TJ ET Q BT 26.250 662.944 Td /F1 9.8 Tf [(Selecting one of the latest S-OIV sequence with oseltamivir resistance as our reference sequence, A/Washington/28/2009, we )] TJ ET BT 26.250 651.039 Td /F1 9.8 Tf [(show the polymorphic site distribution against a subset of all oseltamivir resistant sequences \(Figure 2\). The two bars along the )] TJ ET BT 26.250 639.135 Td /F1 9.8 Tf [(top of the amino acid sequence show whether the character in our query sequence is unique, a minority, a majority or )] TJ ET BT 26.250 627.230 Td /F1 9.8 Tf [(conserved in either the selected subset \(lower bar\) or all other sequences \(upper bar\). Most of the minority characters in our )] TJ ET BT 26.250 615.325 Td /F1 9.8 Tf [(query sequence line up in both sets, with no indication that the character is related to the metadata values selected for the set. )] TJ ET BT 26.250 603.420 Td /F1 9.8 Tf [(A single site shows a rare polymorphism in the background set that is conserved in the oseltamivir resistant set, residue Y275 )] TJ ET BT 26.250 591.516 Td /F1 9.8 Tf [(\(Y274 in N2 numbering\) \(Figure 2\). The presence of a tyrosine residue at this site is known to confer resistance to oseltamivir.)] TJ ET 0.965 0.965 0.965 rg 26.250 276.757 555.000 304.877 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 581.635 m 581.250 581.635 l 581.250 580.885 l 26.250 580.885 l f 26.250 276.757 m 581.250 276.757 l 581.250 277.507 l 26.250 277.507 l f q 205.500 0 0 225.000 35.250 346.885 cm /I16 Do Q q 35.250 288.007 537.000 52.877 re W n 0.271 0.267 0.267 rg BT 35.250 331.361 Td /F4 9.8 Tf [(Fig. 2: Polymorphic sites of the amino acid sequence of A/Washington/28/2009.)] TJ ET BT 35.250 311.991 Td /F1 9.8 Tf [(The lower bar represents the subset and upper bar represents all other sequences. Position Y275, already known to confer )] TJ ET BT 35.250 298.255 Td /F1 9.8 Tf [(resistance to oseltamivir, is highlighted by a conserved subset site versus a rare polymorphism in all other sequences.)] TJ ET Q BT 26.250 259.734 Td /F1 9.8 Tf [(Although the most interesting residues are those conserved in one set and a minority or unique in the other, two other sites )] TJ ET BT 26.250 247.829 Td /F1 9.8 Tf [(show a minority residue in the oseltamivir-resistant subset that is in the majority of all other sequences, residue R173. This )] TJ ET BT 26.250 235.924 Td /F1 9.8 Tf [(residue is present in only 5/260 \(1.9%\) of oseltamivir-resistant sequences, versus 1176/2339 \(50.2%\) of all other sequences. By )] TJ ET BT 26.250 224.019 Td /F1 9.8 Tf [(clicking on the amino acid character for the 5 oseltamivir-resistant R173 sequences, we see that they are all part of the S-OIV )] TJ ET BT 26.250 212.115 Td /F1 9.8 Tf [(outbreak. This indicates that the S-OIV outbreak may have the first examples of R173 in oseltamivir-resistant sequences. By )] TJ ET BT 26.250 200.210 Td /F1 9.8 Tf [(changing the subset to S-OIV, we can see that R173 is completely conserved in S-OIV sequences, and not likely related to )] TJ ET BT 26.250 188.305 Td /F1 9.8 Tf [(oseltamivir resistance at all, but rather related due to coalescence.)] TJ ET BT 26.250 168.900 Td /F1 9.8 Tf [(Site G249 is present in 13/274 \(4.7%\) of oseltamivir-resistant sequences, but is present in 2089/2582 \(80.9%\) of all other )] TJ ET BT 26.250 156.996 Td /F1 9.8 Tf [(sequences. G249 is present in all S-OIV sequences, and has been seen before in oseltamivir resistant strains in the US in )] TJ ET BT 26.250 145.091 Td /F1 9.8 Tf [(2006, and the US and Japan in 2007. However, K249 is present in the other 261/274 \(95.3%\) oseltamivir-resistant sequences, )] TJ ET BT 26.250 133.186 Td /F1 9.8 Tf [(but only in 440/2582 \(17.0%\) of other sequences. It may be interesting to track if a G249K mutation increases fitness in S-OIV )] TJ ET BT 26.250 121.281 Td /F1 9.8 Tf [(oseltamivir-resistant sequences.)] TJ ET BT 26.250 101.877 Td /F4 9.8 Tf [(Example: Tracking the K136 residue)] TJ ET BT 26.250 82.472 Td /F1 9.8 Tf [(Recently, NA K136 has been linked to zanamivir resistance )] TJ ET 0.267 0.267 0.267 rg BT 284.732 82.472 Td /F1 9.8 Tf [([4])] TJ ET 0.271 0.267 0.267 rg BT 295.574 82.472 Td /F1 9.8 Tf [( . By selecting this residue, we can view the temporal and )] TJ ET BT 26.250 70.567 Td /F1 9.8 Tf [(geographic distribution of this important mutation \(Figure 3\). This residue is present in 11 neuraminidase sequences available in )] TJ ET BT 26.250 58.662 Td /F1 9.8 Tf [(GenBank. None of the 11 sequences is part of the S-OIV pandemic. The earliest sequence with this mutation is from 30 May )] TJ ET BT 26.250 46.758 Td /F1 9.8 Tf [(2006, from the Philippines. It has been present in 4 sequences in 2006, 3 in 2007 and 4 in 2008. It has not yet been )] TJ ET Q q 205.500 0 0 225.000 35.250 346.885 cm /I18 Do Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(4)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Influenza)] TJ ET Q endstream endobj 160 0 obj << /Type /Annot /Subtype /Link /A 161 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 346.8847 240.7500 571.8847 ] >> endobj 161 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/09/polymorphism275y2.png) >> endobj 162 0 obj << /Type /XObject /Subtype /Image /Width 274 /Height 300 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 274 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 554>> stream x1 0 =ol yK’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’+s endstream endobj 163 0 obj << /Type /XObject /Subtype /Image /Width 274 /Height 300 /SMask 162 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 274 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 55844>> stream x}wxTU{eZ&Lz%$PCPQ"E4Qʊ]+쪋(L&L&L\n ɓν=}{A$I$ P{>3%Lҕ;=h|Wo~}UA,B5fqIJPGKr1Ы0Cw?" 젰ք}tNsg ?w.$%S*tP_n4Ptݜwl{fe!SCb:<8xgƑ#WQp;<;f|̤vN;-N)rػwV~LAES[* t~RbCۺǔNgՄx?X~V"r% (n@zA885Sbo\:|t ~AI{JG_٧34ɺO\xIBT_m/Ξ^W$ XVY:#g_8t,)&dqX,x]aMK緗[=Z!4J_8JjS_Lk*9&/;o1UnY^`~b>L2FYw5 ]I&h-S7S9NaJpqtnܻӈ;3.CÕ"I Y׃'9qO ŋ%LlI ==ח$b!5u2X84L%aLJ[ M2sAyw˸38g%N/x$ܻ /WR$SqalkjVD`RDP-:9ٗo4L,9elO,N#"' ow:}@Ź/_H1th:t̶p8.b q'9tќ-tp%=] dF!5.]EN+Iiրq nLN{u]fFP_f檰:Ot@w'7[jS+p߲ =$3gThF0DF&NCDdw0j߆r@`MH语[XlQ*=BB <So/%@$HFޮ ijp||b`B`h`@".롽 `f VTb {>&k2B+~jlI Tj$j%z{b``s86-XD"lin냞Nr Ba2f3!@@T V+x{!@g'dUUkRR$IJD!!X-Xe2~HA&GE \!bFÍ@gXlaI*X. 4,b4^?Tt2, E"ĺt72r 6v@g>Nx^i0E9J iݔ9sphezwҨ:z'h9`sZ$\Ƚ>7e:^^$ObaHG9sֈ ҧn7e.i;ϞYcrf~`/+K79GW "#lx;uZЦ mo潳t AÈűl4q{pH1*ju9X~[1Q>NU*`WtLtI~`#0iҴ;qĉk>#$$0 CPPŋgϞk6:uWVq#=$%KP?Y,˭V+I'jHX,~mbboFcɒ%$I6eΝ{С Nw)~XK\fgϞV`$ 6mlvTh:sSKm I_>|q>ǒ%Kl6ې%K&$<1. ؑ/rѢEɿ# CA̙3Δv7Bgot7tBpɿ#o $T3gJy$IV7k$ 6ܢЏLoF?saX=&[߀ ?ԗ/Q!bPlcX~;G0Ci$IVUUFI 3dJ^bH b}<#GAG!4$lp@o  bYJדRN>;xرc.]~ݮ_R5tf{Ϳ# CV}jjjH$IǓ/꿾-悽;zFF $7..]s͞={td(/? Oվ0nHKK g >,G,fl6[(WVVק544 hɓ' P*͞>k` ^+z-1mrܹ^==hZ[bE^^\esz衃F, #/ Z.vȑM6h@H"?<uLg,hdVƉX,޼y~JX,X,, +͎Dzܹs7o>rȪU Ri0p [,f{DlaBWM/̐8XYo >bތ1AB( 1v/ ns#@V3lW Dr헊@h4U{@((^L43Xp1&t(dJVZڥK$YeK@lٯ+\1DM'yP/| a"dO.bD8zѪMK>7r ^x/D6mݓ cǎ;֭[GcX18[Jg*+ 0w{q I25ZBfN;l4; 6'XJ^ 8`hSV夠h@+jJJ% B뜽d@.!ԡ08(wZ-@)^W%@/&(ph%pQz{^Ǟ<Ǎi3p ߸;xagzz$I6mٲe?,,abtg3g:r{ݟ}YUUU^^P({\|rX|ܹM6lC ̙3*E-^ի|>?:::++A"cJNNV*\.w޽l6{ڴiMMM~~~۷o7ͭ<@|||EEE^^hٴiX,nhhXbEtt4ΦM|}}CCC 0ƍ[vmeeeJJJ@@~ڵ9shHR9k֬ *FxǍWTT)))Jb= %%%~;|䰆vwwm޼… Vfffr܌ Nի'Lޞӳm6Fe˖&ZMiH${gԩW^p8aaa*jӦMUUUT\ؽ{L&[j+++BmۚX,֌38R7o˯\b}Y\钓rfø>.\4iAO=T`` noolmmh4<OP8qf]vMVxС<>{qZm6d2ٳg/^8}3gd2L׿BPb)--<&0;; wQdF6,H$:{lOOǣ΢"4DC1 >>|zLLŋgΜ =z4Ad2eggs8;S*qĉxaÆ>>8T fѣ?b߿|}}91>>/$$E|'+III{KNN5j=f̘#*F=xL>00ڵkGI&I$|||{vv]F#% x\`J˗/ܵkԩSFGGܹSRy{{O<CdYYYHHHddɓRiDDٳg\ \xSNuvvNf\pۊ TQQQj:555555###))iԩ3gΌ  gMvoܸqƌ`EFF$$$dee5*###--m֬Y 777((HP,X ===###..d2@jj̙3-KFFĉGJZzz,fh4NC:::FP(l撀l +((ׯv^2 \BHOOBPp3rwH$ tV}G8SN@:::\ɱX,YYY&iڴiׯ_???^TjX4MXXXoo/LMMh4 ,,X՘K.7nh4 .~:f^ ݿɓ'rѣ{{{ʙVX,ru2 &MDOPyxxXV\kfӏ}jSDhh(^Xߟr7x̙3gk׮mjjƚ3n8Ld+`M$ij˗/111pCPP؋IMjj*Fre@b"IR$<,3000WB]Lk:::t:`{]ۍ7cƌ1ϯZ-*:L tvvnC\.fgg暚*..p%feGGGMM `6Q(,K,KjUU@ /]yommݼy1cobqHHC}7QUX'|;I ,g6cZYYT*o4=<Pr3 AsOwp ݱTfDJdggKRD"'N(SRR9Hx饗wfGQիkjjl6mjE@up& ?$B^v'DUnj0 Gsz PmbA[likk3=`x_~fz}aa'[zΝ;eُ_rI@SNacqA7o.//f\jsY:lFO?HWW_z*?#ώ;:;;fsii)Nxyd2`(--5 blٲ\z(.\طo_\\bijjF{򈈈gyGѭXqX,ToBߟF 2\?0_R; ݩj}uZSSCDeee__Bq \TT2K NSIII 7HQT܃W)ֆ"pʕVVWW??#NMP9sh4:5}td@;~ϝs$9r 8(T{-csO!@yJjq8~ # YÄx<ޝmwb9&"p2JBݸtp8<cQ`l:(Q"20{/I111Ng_t*^__ۂ9mUO}e\F@,9I,{gA*s2Ư}0]1G'D753q*`ZbohDEgؘf>b`dwg8b˛fol,P=q;sg_``2ٿ?J9v. Cns|^t w{|@ P*W^7nZQ(*꯭/Ybtx@yyyYY]wu% ҭ W^yeڌ+Wle 4 vjh4 zѨl6N:NQ Njqg6f@oo/":^dU;TW[Lm6j3f̘c"ܷo_dddqq[o ?0nDM88Zt)>Yf۶m9={,^;vʔ)hG ֮]{wISRRx<^~~>zKPlذg/_<&&&..駟F*񀇏OVuፌ[쌌 Kw}5k 11q߾}G[bELLLDDyP$11CnKzz:&w܁1뮻`ʔ)"(555 Ԧ"+J}tӟ??;622R }:ƢYYY*J,aA"k׮Rhll!!!3gliixw;hiiR4)))66.E\DDĘ1ceG%cGGN?CFĢ'&, }7 ''gǎP\\|) RbQzitJ=zԻ/8 y>hZL4n$I.zIS&sss]DD1_,1jHJIIֱ)66$K⮜Jڸq#ЀK,,, 5jlP˱U;w._PTx5YtB6mVNHFZMM͂ Fchh2p$={>@2ottjdQԯ[;;;`ɒ%XL 628>_[[tRd!ʾZM6uVbb޼yCLZΝ;@*RTqa+h"^]]]AAC疙8xq'L/doN<6Lұ@ @N'\|'222--秧xT\1w۽{7-((@RSggIX'kkksrrpRX__O5ؚ.PѳX,7oW_=V4պ}c"9ȑ#X-KyyvddEvuu!sÆ X{KJJsaaaR w}1ǎsX?onn1POO;+**V+UL}4c?#j>sjԼh8x/\.?ݻhf׮]t](bx(k$04dh4{`8s f3Iz^R3'СC^^^FGMMM_,>S80PT4 ϟ7mڄ\^^$+gl۷otQQQxh4cQ*f˃aErxђM&Sgg{G'⒀K[ӟvڅ$IΘ1`8 EٌAlܸ:Ƅl~饗>'d2uuu9tK,9rK4lo Aoo/u`¸qWL~ͬ܀ w/uTe7G0__w58wOᲷZ"ɡf`q.x4;UvL,@2NٹUC#Fj'Vvj G~vw]5|-*2wFMc5i% d3HsCP }a'̩.`ݬAaLغLoi;: `hQPٚS:tee L:=`+ϰ5Aݻ~d:p]ܜpYml߾iW\gL4BҸA#.@ Jy@ev٫.F3v$>kZf+4\'TP4$Lpꔽڌal'z۫-ݗQ! `f9Y2l=jC}؋+/Xm"#!b(P|4Ci?Xh:8%Rs(Fq`{LY?̝;wcR~/g9e&LNq̉*sԁ[M)DvvW_}~!A_t_G0!X,'|3D"ѯ.@كV9srr"""e2͛JKK'N%J222R\.={… ]6qD__߰0Lvӧ_x133G5&)33333SPL0aժU---+ǫ?~5k_n4m& .\(\nll죏>zu^OΜ9$11QT$9uԐܹs+V0aBQQQppƍu:L&{Γ)===oNDssߟ{ڵYfd̎G}4 vܹsϙ3g|޽{ZL&[pT*{RSS ͛Bacc<]TT$ wddd>>(H,..>qڋ 吐V+8<F{5 Aټ|6oo/_j|>?** 3z/ANdMMMx0?//OVd%$$<7CCC~i`ٗ/_FF$! m@ww7Ex"n-:tRRRgd2Yll,zLIIX,|>?''_~%0ex"3sN:uϞ=\.7$$5~ivvvNN΁(5888;;gԨQaaasaZ|}RݻQ퐐I&=ӘX9o=c HtwPF ?sWX:.>>3722Ndjj*Zҡ]B_f !YKKΝ;O8%1b(755!bŘU 7 Pj*W3MojE ONNR.\kY &ٳg)#6~xe@G d&L@BڤI`R\\;`:,XΝ;4FZrJHLL,\5:t߿I)l6vh&cymjj@?ᅡ$iӦQ&ѴZmtttBBH$Zp!=\.X,l  o&5jT@@ڞ ^dfx TfX,զCȿQ8jHҒo#3>>~ڵ /'4iݩS(B`0`sZ*AAAFخ_TVV`GBkBRQQH<<<ƌ#H0AAAHEEE%''cتU ׷nݺG}T#h4u[gAV=u~~~VU|&LlZӦM2e ގJ$(MZmaoo7 c=\.>$//;@\.O&WTT`ե}}}6l{ߎ6lzE E._|bXxh 6{s?~|GG(v QTo۶ noooqqqTT LMMNDh7ʕ+_www]]|Hջv튎޹s'&=*HN:}v4ݍI$˫Wl[TTW^^T*)]z56%j`A|Mp|9s&Lu-[`:@# @U!G]8?H76iۉv*4Fgoi8˰9h onD sIR?۹s*/0ծD)Bt;Qpnp-NAϵȥ $AOǐh~==^:}b]t3foqc{='LbȲ4̠Wͬ#E nRj&{ R,EF`U;t:gh/8L3`^&,6@w`8Ֆ*\:; (pHԴzv@lM<[2B#C@Y R *COйx= N7MD$'=RlfG)%'N('I(-23'KJ\4؜_%;9hV Szd%pd8f?# L{tt ncC|})Z_f]agaӨqr2aUe&Κhync/5AEsIyC^ՔtL\4P:L40̹H|@}QdD&$sA٦w .\s5A! OTN :WfP +ȵ_TakBp8rw'uP(DCƍ{7ϟꫯΞ=ᄋ~-PlիW]v._oOLLJs^pt hƍw}7zGsիW?C駟{cr]w۷O ݻwu޽R;pԪUp&N0.wGut ?1["_ܹ7]pgnnYV\\?oFJJJff /Īu֭]&O׿ !9`ӦM󋈈x'njf7mڄ.c$,]taaayyyȸ4i<͛鐚;P$0/ Yy=A̜9/eX6m+pv޼yS"4~T{۶myyyw}w||wމA'&&N<$v~z n ފ+rssd/#WW^40arU\ݻ./0 Y,7-,,ϾuQ4EwС߸]M=effxLL/{󱱱&LZ2f{xxL2JOOwPH((((--RRR;|OzHtʕo Ǐ5<((gAĉk7orgW^^V+^o߾>w /pJ뛔$%ɸq0?>CZ'Mpr9F|сtQFq8'>3ׯ_JϟxX8?2&M&̙3;::bU?ه$F#G(۟B+2w,X>Că>x>G*#cҥ̗.%n>xb :%% ~w(d^^oߎa -jooryH|{{{9Ε+W( 4\@{{Ohܹs/BHHJr]]] hD:`TSSѣG;\]UUۋ7zxxh4qơ7.cl6755QrJz Ez3++ ^^^X I!Tݻws\^. bl&{zz֬Yf6\.ϏEMMMqqqب:uJP z"2a,^f ɘ1c b\`V"S16mĒZ^RR {I:utttbPX,jMlŊXѺ]kkkuu5ju 8~8<iiiR,5ј{;/L?7~XL\xM꧞z*))IѴ"1O@OO\7[VVF)F,???XFf۷yPhY(zyyD˖-CV^+==fz*cjȮcǎ9p"_>~xd0Yl6 b```II ŲZ/rKK }嗑@P(p_ǧ*88m'$$L0ۛ=(Pa]R)t: ovV7Ĵ믱qY Kee%p %>V'N𺺺> Jeaa!htܸqǏGW_}u())`Z).rƍ8F4F`ȼ*V!" jN2mgfVKCCCWW뮻JJJ{zz= v֣RܷW*HJJ1J*//V ))))HkmmF <xٳgy؝;wb3YQQuV̳'NzT3p BY[[e,Tm0]]]xEPT`\j#g$͌澺tuuHȉI6yأW^U~kٹsg[[=SSSi&Tքm6tlwKQWTγk׮;ѣUUU<00zݻscǎ]uUt*J\.ްaCCCC(?W\G}_ݴiөS֬Y|ett߿ptvv^wnooO?Oѩk֭ٴiӗ~\L644\Z׮]d|h4C K/"]pUUUﯩinn袋뮦&azX,Dy{U^xsT(JzQ)'*BOL&|PGdgAU6>*]EEr$^'H$r|_jK.744TUU` TrONNjfDW\*dM&/KTQvԩ|׻n:ac"4x`0(/4 <36mj]t "+**t::_F/!hBrhnn~ꩧ@xpOd,3 wvA 7܀K~_TWWkW^y8777>>j-Kcc`P*F5N;H噙't900PVV+@*'GQ?er 㩧B5o^ 6<DE56mÆ *jO>믿NjPÇ755=3Ha1q*Po@4===|݋\&#{zz] o۶mΝPWW*. D^ ȼ (N 7܀۠QN< Q!{E&m۶[UUUp ҂2~TnݺX,/袑`08<<}v0G?B]o_χJx^/:CQ<!T@ *ٞ\B0ɓ'կnذ@ Rݻw$y>R~sC>w}7* r\n}Cʢ].R RD.Z}~z:B4ݻ#JFTU磷 >DyyyEET788J@rV; L&Tʉh3ͳ5 8>,+8q\q5yt:3 nooG5|Ynk4fff6l؀eo~QCKbg,SO󦧧q~3yxv#_p|O?T~aZ媭EV>44TZZ*=c.kʕ5s8(J?W jJbY[dJ.C4Qߠo+.4iFuǏGoE{ ir?'$b̈Zr9uppP(oף~Lvq^Cb`G~ӟ"1==Dj_,‚ZFgr|$Jp&&&JKKq ; ?Uz{Ж;w*t:*" ;tzǎ(۲e˖-[dz衇Pyaa!ٳ\.xvB!xN8QXXH$:Frᶶ6t,v---h4<2Ӿ>effٳ(LOO2SN ok1χRT`;>>/~5;v -E russs=J)gggQ믿3TN)***B a) u],˺\|phh( F͆,?P%z?oH$8333@ ߏNx< FD&UWW{}}}333v766v 7~ai'N@uuuwq_?tP"8r}D,~LO]rh'-W SOK 7mrsܴAhRQޚo2B8_tM {,lxKrq$ܵ乓>˿7f.:&w AI.~;p2CA\ `+9 9CNpK.0D}n@ﯽfU0o}vy:!2T*;+n~.YpK [zfLt: x_Wg+e}[R5k!RP#zZ_`EܷM\F6u:/]ҒH~\U>7P,^wu\ <`EyR-Y0*T`4f. y"BqFJaÆ@~g~@qݺu@ꫯh4;v옙I$7|ݻ;VSSo~gaa[ݻ[[[ovi=NW^y%}oZ֞ok=vn߾};j߾}#GTUUo}Y,~:ٳk۶mVfYf\sp {:;;կ"#t{/:~pGy$OMM=CO޵kח;%'''ۇ>99b[ne0X~[[[.ONNn߾}ppK.]^^nܸqbbvﯬڴiӆ L&*..>u,,,|###**bO8Wj*TD0L]]̌㣡P_2ԷmHH@*FF3g\wuHmr.rT>zFٷoԺС{^z)2xWWv/<22jQ*hm۶3cDf۷oؘF)))!1KKK)B'V8FObkсG(mѤt 8Os 7SžohH$(,--STyyy4EOR{/(kJ¿G}^^ed8|ԷonkkdHtVB4lܸƖ첂ꪫv! ST"H{)۶mғkyTGa@6Dz,ұCG@AA:/ ) w|N''FV+>GvsQ䷦> OO:>t:QȲ:>n>33|S[[t:Q[mh4kcbohhC5rΞ=k64>s VdF.P+`? B/dIH$L`===gxx088.(P(*VT>w̙BގJc_wZfgg{ ^7T!^|Eğ_fBS:44$.E055u1>?ӆa|Doo/c\[]]F_>zߎ츥D} 4٦QK^o DŅhy_~y4M;AeȩT jպ~/UbǏz`0 QMۿb)~ll+H$ۇGW^y%9r[o=z`ooo[[b;>>^WWgwYB'ONN:u qGپ}{ii)I ;;;~>( s=W>Jk,vZ9JuN>Jc)殮.j׾5:;;?#_nd߿PywߍAc^z)Ll6,z Df&GUdr($ /| t6ryyؐ# 4:Oow , r^|+9 x):9r83+~IfۿVQxq} 2GK@4 eSx'Z^@g;3x+es"\|I `;6ɚJa!"@/Di>o|O\C.w;ϴ+}x?m:/w[s0xs ,2;idVZZH4NRDgⳎSNqlkn7zGVf-ğ Wը%U'у wF#LbMM =5lٌ!}ZPtMi@]n[nԩSÉDbttK_UW]uȑtoÑHz/PCCBUVdb}w'|RӵtM&K/VF7|noogY+_ g?k06o|755,o|#??[nAG2ڵ vWXj>#---v{/{4իٳrʾnmaaaz//**zO={NgSSӍ7t:c~C1 }Y.oݺ=~n{W|N駟ve]6446}>ٵkg>?ͩ|7F㝴k?GugffZZZ<Oeet~~;sW⺁?8e-|o`hhhxgx< / 1\^FڊJZmMMϜ9꫸w֖_ T*tҒh|!Z**jRh88tP<WՇF$_yaPAyy9zVR<CygPUoF{{{m6ڵkg?~P[[KӴU(:raPM/Ç~x4M4}7c{\ZZN=y^Tѳ^{ !?c_nƿD[ɁIZ{7d2fD^/:_t:Qt$L]vMOOCğ~ip%%%HgƫWv|̙36)bJOP=\._r]X}g_xݻw>~t#Ԡ,ԥR+ /Qaɓ'Q[oUSSMȾ뮻Ua~H$RRRt:}>oqm]V&ڐ{6tz\.袋6np8PIF~~ʕ * l @)?ّ|g@PʉF:667EQ>-xv;:onnwEVT*Ee~矯kooKP &_UuvvbX,O>>F+hM$ N3"@ӡF)BZ,TTVVvQT՘bd2Y__  i!Gn>Bd2x fffE,F"Q$M%%%Ȏ_|ETVM&S8h4((iQh4>FEh{9֫x饗998'6~ltt4iT N<933 GFFq8W_}3gdccBE5h4J 걱1͆AB (JYE1L~G[n###x6qT0L8FԷ brDmyy9Ze]vȑH$vړ'Oz^XPPO&(RUUUQMyM.bэ7 twwRWLMӛ7oFg>W_}OLOWWwL$ MLLx.@7770˲k֬yw/h4Gbl6o޼v=33ʖRK~%x/M>EP*:XE  S/^4˲4:7r&.|\roVbX{{dx|nnh45vSS_Ds͚5dg?W\YPP֦jwaP+"^DQ_z˖-6Kܹ|q{nOd"7oVAAAkkPGG{82?O\.]PP {zz}pZ /ӧyd2iZ۷lDv{OOGhO֮]{ȑ/iRZZ:<bYvϞ=6nl6VPPt:vFb89j:?!+aXÿ-0g??={0 6:.NnFDBPRt:MӴBH$9kzsSH$rPewMhXeDY62FF@@k4sGs\bXM̋=)_Ot=Rd,V%NVFLeVJ:r d `\̲XsSY.[5Ԟ+inRC]qK:l0ih4@.2AI IJW"W\[L$YV/&@.g"I:=1RÑd-敗_DޮR ^oB[lS]E'gF>Zu_6l2)CgCl45b>5vr?D"Tl͚r¤ӹj|d*{?/UslT2-*@62 PN $~6apݛgFvev?>ݶmMSSDbfarr6? E+VE?<{Ϝ߸6wu:ǽvY.+,kBiݹsLqcxx)(CnwN\Y\UFhje,(ehlb+X}S;vGrd257H>_phhjݺj\?cD"6x8vmcW^wah4ժ}izHEEp:;HGPMMؘhYF/i,tmmi[M )^jH n( -M'"DGYa|.("/H~-N%"ٳ+O cPXojR.kkK m]]y2N&S5k*ZFe&ȾbE!㑑i3 cff|=:55722rY =00kjJgL&ڵf j5,''iFQzl jU}}--}SS078ten.G;:ؘgrrچ<?0--}}Nө}PIo-j655zNB--} F`hhbl3>>x{@duwMMDjzz~ppرD"'N BT:Ot:m(5yyD"vU*E,裶em6s*j'ʢIat:5ֶ䝂,`'Uvf(EP%GxO@fMQˢ?asDͤY63{(6HٕE/LGq^Nj hԳ,g#6\VPVzaXݬPzfbrY[Z m6֭ x"RB^P?6橪r+rR188i6nA%H*әP6ժ5ZriF. ::]QT*ss[R3QbvKoeM$Jbttj5npxg]]Z(`\x<&K*x|kTl6f(\g7m NLlk%(c q/m[1D "DDgRXa",gCRpbd0m6*hLDΕ{0E}gXڤTPcPa< ىOc :fQ+p_RX E :h H5 DFFHF$_#HoJrMe|Ed[oNx"f5nu:5˲DJUKd"FFE)t xq5ŅIy;X"L1bGoq)8( L(1yJLh3R";D~ 7-)qRd2R)40ۇQN%& }^i:Y,^MӉق|RJ(<b`Y6b4av Eu: ls$UB/IΖx{+ZYb2FtX ,'M0ٸ;JE0avpp2vv_|qɓ]_a^D'EA^c>d.bd$ yQ%{&E SK&tw -ʌ%W,aIxJyցqoq4LN:y.UQUWޱ"N?|̎?l$ɨtY;bE\ 7R5!?l X5ZG:glj\f^)//p: \"`[8nHdϲ,08T*61f~vHKSW”) .L'S$=ˑE3ElX( \xaɓϫXVC}}mmP#X$K&S07JZFh"Oд\RXQ899~}Z#QdŠccD"t LNO#ckgĉQ/EA,p35 E}ĄWFc_J,n˜j( Tb)G:BYe*W?1!<3BkTjPӡ|QK=8a]UV ҋK&ʬ8E0@ܘKtOBtA%BF.HVEA0U*iTh\UɑRVZh\VXQDQ7o^TZ״ ^] D,tTTdSPUUVȴiDbZztt FrYQXV-GwB vD2NYa\b@ڃLR3b̞И1 YY lW8(NYȔq!2EW$CpH8Pq h2B,T@j<.2-AѸDzё#F D2aRJ4ꋦM ng)哙r2!hɒxEQ%H|-BaV"5ԑc Y1ZDFrQ8 gqĊen4D L.ڰcl9)R隗*,р"c!g>,K j"1Rwb8^D@2k [#l6inijŒ4sdbY[H&^o LdO 3K;#ږa12%BE9%˘0 Abc9y1BN+d\NK\] Y0* В `nJ;GqeU @LHtlBXd$deH$'} z]D5.; }qH"娥D6@ 8l:0 7;x|>|d{Ê9g iM,4|Gdjf38+ټȵA !> f$&%fV$)$l&dA 6^?+Bn%R^:dki1yu7?MMͅBѦ.QCJ)M)p9%*X86HX6vb0hW((Z8y 'Yk YU (-?JЏ7QApDɐ Z-qFDdb8 '`dJNDJF(B9%N EA p.IJ1(f($[8))1(Iџ+W|>shapP__ڵD1x'S(2:# llfcw"P*+DE,q0gYb0l[aFY?韈·rxF"0†4A{ JB(`Dueibӑ4c9" eU*)Yl`jJrl@ΞL |B!7"KiYdZ +,qڵ2kj*M\Q"с_$f&ȶD}IU we2:vb1!VNcd]]ٳݣ謟h4QV B F*+oIeU*Gv822аBT!WRK2>ŲT"8٢"R`J`ˉX XfX" !hUYRW{ نU:dqd9!P(bEN9u[ՕyJJJJT* <S4qr,͂!땬F(X T,b%?[(Gv!v=mmK.Y?βloX".ɹ@ \QQxxGaEwAEϧXpp;==_QQJu:M"e3L"NcY' \"jGpHR@ ӒlQG6y]L. %a$a٭h,ڬY2 gGE 1q"gpJ2LR3Z+ep.m dC %Б]%HHKt: g3JRIC6fظk`܃3|$Tn †%{$̿mX%҉$c))C)0ry›H ؖ &3 CDo,"'zơhJ5r~L|- K)w`8rN Ap33H3M` fi6Ͱ2e J){[40QҲ4kG!f$' Y|΀h˟r:Y&PMzMl/ d6Uhبݬ\_cn:`BTQ0l0ᔆS&^j5*KO_'򌊂|5pyլjPT"ԔꔴnQ@8e7+IO{bըuez6몍nI{$LQe _kL, rYBBR VCY-fց,<&¦GI'0QD@t΂y! D_^R=f,3bߒXp'&ƀޅ:&ڈ`sIbXK u;4`.DT2c2$9i<,3ZI .}",G"$hJUMٿ7Pva!8D"Ms-@:]Mٙ8w$XTtRvyIYZ2ADͨjM]gr\.Gjs5k*U*:FGgjkKGvRX *ްﴊ99 \H$k&R)nX B OrȄr:iWCB^_hdœ+2QiĢ8^e)UI-l1s$^D)%fȿH %#ѸGJĬ.v@҅%1sYRzY\@%}8T*V,QV(^3?PQQX]jMM`0RUV2YD#./7k %/L奕=.wJݲˀgsYbaTYsOY-ܱ,rc,%=4F,o# n-6ɒ,DӬPgFK!Q#e;$~ ۇ[ s]pOb[jj[.kFz iլl+L[6d)3#6vb,E K$ikٷd d)V H$)'8<Ą6LļrRpYH8 p$PBuS$Nq#\4 mlQB.ChnU'i9vpHYl٦hCН؃e|a+,MIcDU@ҾҎ%âbiwG.*:u/ٗ:V6 Q-F~ א %lR7;6QIΎ";i<%=KwCAl"_@e5].x(Jm}DԜeE#ee&qGrDwM~ވp$+.l^J4S>d)|S%y;IJ𮚈Y22 }$ёL P+ AHQAtOrKE0ɋA #!bD/EQT=$bayJt EA{Pq6a\Ŏx<ɲlq鴾^uUpLOP(j*Y,^[\y5ZS ,tl7Ь<م$74;5sD݌Kd='$s2 ) @lya+"sXb͉:~nӕt=Bb;,5E$ 1 Mr>nDΈOֿf>a)grΐy9Vt eU`dժ9һ\VbnBo\D"YZ+zzsodRmvm\R$Ԍbch%cpkw+sbRI\Y`^V2\Xձ\]((,X>ꂉ(J(L$^S@,֘fa0jHpvrӕ=#$8DŽ枙?-~\7 2jHq jkKgg]v\.[ *+݉Dh!pX\.kIJ'Q(4iA@Og%1Bd,"dH.Y~ٕ 2 "UiCTW2, "DH(H Oq\ 7NQ,҅>4g>)CVhLZ*BTäRjHE.X N0OAk0hџ Z@dn4#"ix~I I`B|HP4(d@QROh a H$* ېP|h`y3HK&Hx`5s P%'b -|nI"w$/,zᖄa P ,X& $Y>x2F2'?$7m3S⍄߬'gn5ىaq@C[e5#HmqYL06AOjN⤊MY?B#ظHG4(&ckf&.XAU`\'XWH-qMJOBI-3]hOip,A C*JJ!Ѥan a";E0S/R* XH *dT0tʪ ptLD n ,42$QH68⤂OH c A#eLFpȲt$ !cAF<#|+).HOx% clh:Ƌl@ԥ*bѨK&S.wb1< @mXJFm,iдq#S!Kمcy gD!#p0,UY\J9W"SH@(r[(I4Pa #%ad\{IA{ p4>_ #8;1OB8, TD^@Hd#`#d&|̧jh4qcUmmؘ9y EO*+sUVݶ'::{{M&/\S! !W *= 'z{;fDf0U$#x XK\}-w=/מZd֢8Dx5bpN" 1<翹Ԏ"uBpb̂IΩBI), *ˬf1"0K6 .ǝ6s۶5FfX,QYY$7k#C'rj/VUwzLmmS.YiL?e^GG=3ӵtw,E }ǏI>t,-h>Fv/B!P'V a'>pAE71-,,ƲE7Bq+]/2 K>G7 t: !qsEÂ<%J9X#%mժ{Q!'0`j+?FVl<P&sLk\U״00;/׮S { ٹqc!4đ"@m'huS)jBv<8:v ᗅMt_wxI6ޥ UrrUW)pKLKɴږ^R7|½p iwQ񤟘8D Q:(FTH<)$H;<Zs9c:1Q0za$/8 gyh.Q%M" oy/SG9O_K/mqX?NqڿKPA CYh0PLSrI9H@f@o_Ysr'M[la}3$µh:,MDd ]mћo^~xiY_)s]8$Sy& Q{ %J#MEQ~@$-BI:˗Dv!2)^"Ε$:(ZC'u>n.vi WH2yJu_7 >h/]S޽gp[+eM&ottE eWUARy8vUYlɔClC;=C,c||I紮J`*[1H ?ImJE"zB(+ݰ=X04D!p nU [yD 7c!t6е(IZoj+" w͛˘$zk9OM1r0 P vZrhT$\-kH[e҆{?x`s7J'&@u&ZEQ|0#h0DZE dO'5n(lp5Q<0 H ɴ"-CP&uIgHD!`׮]$ȒM*-1xPBR@'kM9O6ckO q>qh,3(: Dtա0QWqC0:HW"%L1T;r@ 'Y(P|r.ҹH]S, kPfZ Tj4SwF 4>,@6@=Z%{{#u8QvkϪQ4rXS2 &Qj ,Ò2(3ҎQj22i-3ʠ.bPLD: UZdM&IV]Ymq\v8]-n4U^(xU F&!.&fR%EMp;y_\UIZPms{V~'(܆" ؊ ,tU&j TM8\YJ_K~f%!m!Sa1Q{ͤzpMQ¸z-(14)ʹP(iPкM7 Չ ;wVq>i4ڳcwǛ|& w:H$cDPΎ kŕxPj*;sI3H6Zxʤp54kz0pg9D a+(LeQ) H.Haj JUtvIm@~ 52$KA!Dŋ};Wwv'+PnWIc;bbYUNJ93ݩ҃ssնj;?-끌pΉ84d92D4n1D = !ж.5sPb/j8a D\DTwc8J 3a&C]!Tv14V6.M^vqmm?1X\i6;mӣN\aeL&?6_$19f.ь#+Ie8k;puFyb&qJt:"O[ KVT)Dk"XLJ""JѭpD^³qJGtr%3J+SDPq*~@dL7rɧr9zko)R8RG90!y.P46SV:ctFD& (0  c>hؙ(&m>p-*+ʲPT)L)4 @"m3)j/]d!vJIBH/4B ĤB wTh[j^hQK JLIR*G+HLmۉZ|鐦+$JLӡbJa9yB K"5׸c CT TXAY\ ŗ=ͩa!W?' [xL%7Af 扺׈.zB#C}v8;ZAp˶hv,`\J6ru"1+#-ҹtvsHnGSͳ?t^Y!nd<r)܀tzٱ'O6GF/v:P(ϧwvNjF;ܹW*FŝR$n4ڌV79Y=ǣTb076_}I}li4tr0"p,M$bjOZa\` v >)+&ok4>eUߙ0B #h~lQ3 sJW2jKm=fQ۞VqE0jCf\REeQz4FŨ(}*Hi6^$_sZm&^ov7+Blrm6Vwo/ן͛WQ4T/N۽|>=إRxwdXݻ~~w+ϼD"& " mB5Ԣ4Z Oޭ;z֫WgLYzYX@pG%Ǫ*>Q>)a qFpB (|XʒPxƹ0hjtt-Ʉ8|zo$LN U''KNqq[SSx<:77\8.MG|>=;;N> C/{TGGG]Z۝N_<[,}@5gAM/ 8_^oxDžF9p z}!{W$2M$WM(^"FMD5g l*Ih>vWz+}y)}~0A߅8o^1,QXsX}iyeϳ9vR2~Ť$J*˴bxĽHGl pQ@߲!]S1\T>5|{jhBE@7)0S4%Yil) p"M"MR% N kJ\mQ Wq?*$C`q*`o*f M !U^ry6TJ0ksӐ*Jk7PH(RikČGiK[  tGGi +#2*UYm~yEX"7N<Ѥ lxM&H g7үZBv\1$޵"?y p8mqa>p5?L~npž+Aj~h*éBZ7\+ˆ޿0M#M#/:QY[۽~}B|n6L1*W݁yB6@?>}O}ENOz9<˥XڬZT"NضN'jׯ_ǣ[OrLҲ۷W]g?w2e9Rŋÿ8VT*^;;;x1 孭-uĕ+W=[ȍoMODfʺI <  *Wͬ{D*@JA(Q9A+y?䐤p*ݐ91F |`W 4 N]㱱Z*J^{8jukTޞq.]GLUsk߼FnZtz :~==qc>D,.N͓T*0sN'AgMMWWw}{._ZBD2<>yt:J%N[U.OOOvo4|qp()TCST-G`&'>( x&MʒRs'8}&]c2t)pEP-Jx CeU7 3, +h4˲{A:l6B92 Xg8dGGm CpضX,RD3ضϧ;8xgYN2t{A^y-T4 BfXzh4lvsT8N'tm=_nH$i>rVkjj… a=w>GQMwlOsQ,z3cps'y؀%TZ77BBW(SMc a-M"~V7ڜx$Tj Lh_"U>,NQh5gIR~|Cr@Kx9 `&cbZuF?>E(uup :L5awIۮr@,klNU@>Yspш lk!gM{L4"ً ,ñkp GܲPEnwLƅSq&gLmWJ`Z:|8 6tz7>:WSm48`~˜g'bjӥFM`tBbGYk YM{ҥT橛b#EWV)?VeRڑ ig hhM]41%'Fg4sNڣG?}l{rt|\zu͹񭭣L&g{fftk0K9777V*VǑV*u_w?ޜ9>(UL&H X0r\=nDEɉ%`~@oRX8hkca6U( fwj2/<&@f6Y*Yn;k: ܼk*@6ڼLQcfx 6K)5*G g 3?EӉ_fS4>km;_}8bJ|lv{cP466OOǮmqgfF-O?W(dVV^$1r:t*%uyȌ)߯rZ )ܔMJa(~ G) @  Q4ph)PH [0it R+=BY%81(Z4VThU'xZ!87@yqT>q~+Մ4T+^gd%=`b ĵM'莊ƆrbWw~7[\Siɳ`O&\o‚1hi7-0i!*\Q8Q wa^ TOUM#\Ma?($_n{́ʭ@2m)"EP'GZ>Qo-Ɛńp9A!bhlpbZj`x, u&x+ Tto ߹* t#T]PaVcy) z4)D&Fq0j=yZ$f?=mc'cfgt4w23S#&KT$/?yҒD#q휘 .VՑZt{y< v,_v϶݉LF~ Teҥ)20ӁayF]@n4_}zPPQK疳) (B&6Uc/9*WaFcqv+Z$3J\ZA-B>4r!:SΦpHOMiXgoCM*%' ' @X'-r86o{{bj]NW! +4(5bO4`})U1şGȀeCOae-j)YpN(h$NSPo䆛: b⮨ 5Ղ<*[elq!ܦ^u/!gCPhi"D auH~xF⌚z ?VQi( xH_ZZ&ScI2:P,H{YF:D1ZZ5ӰP*.mY6c, XR/`N,%۹A̝w.' hYhDCĹi`\(&ݛ'\ "uN1Xsi-MJJ PL*18W;5@82J'eT-RPH tV24 05 JJAG!N'_y{Z<55U>88 ~z7wwOgX̦S޻Ç/"U*rj\.93vEN:Bͬr3;m?Ȁ:V#@~ @ G[*9vcW|]"tn4QȰDY_EJ*MA$> bw0hALÐU"#'4ىw1L晊*pmN||P(d76/<{83s]n6ܽ{oaݻ&?NNNNNNFbxh46֡hDdSeDUb]r,H s9J6 Wʿd"Ț1uAk}fВ˨ )cISE,M"a>U"L=Ie:4M<4;::^og;;J<[^(ݼyeb˥\ tWVNNo|t:…hw|z@u76R/#\~KtVtvJ "ONcMڟH8g*LՕ 3j=QJ±~ p_G_;f#F5 (IbXNLo/%?Xl}}嗿g>=F#NFGG-ˎD"猁)5VQc˰?{ dT$SJG^: b"&3tt) 0PP@t Shvm 2Ut>PEra)K)*FG`0L<1]ALSjA!8̻p{-M sz,ky9H8|OB 8 $S{&YNsK?HX0|t˳$59GZ6ȈЂQ2P/wHjr(A69[VW(!wxL E t>Dk729"duDD4Y<p`@StnGB= ;}DZTOM6#0وkr" jMTۂ%q(]\EJzmYAێA H=%-"l GZp: Ӊɤ $$q2$K4B)j`uqz).2E~3tDBP/SFJ"CӫRDå,5 ÁS`K ЏBlo'+rko/N;_HUav$Ÿ=ˌض vFFV+rx/j5:>>x"U.j$>1?:ONON##vż *E"?1?ČKo1#V֤'!49C$E z ReB' P(VlIy`Lqhs|XxU4CץW\yz k+SII4MWԎT?Q*Yi''&{{I jmJ% ͈e/RA>=g*N'l}=}xIJmo-X{t3F W[@Kbwc5fbz`º9X)G//*o W` )z A&OoYDS.b>B45@jkzB_ Oc(Qb\4Xc݆&GM('BpFsk+5;ۭբ=c`,r(c<"^*Y|f559Qo~SOf.\nnx^ŦɤNf3:?߉|c~>"436Tm*MN n1̔=@+I(ylh AAA՘8 oU\;9/,Lݹ׶_b_X<ss E^op hrp=C"v''=ؤLYHqE9G}.1dJ׉i郲DlsD&mgk^oZ55UNhcpw=~92i{~+nyXm۝GHdj[ zK$bKK3H8j7X-Z]_/N f7,޽gϞ펏, ,Bqoz233= n:>c,N,-̈́B,4ݷ߾rx<ҥwwN<ѓG~Dśv0ƺA.99N&{ͦ.\/ض/$^(dv*X,L-۽x<F,ˉFÍFgttu=u?p XގF#D~df2~j6;BVkZ˥^>al_e7d2E;۽r98n$Fшyj\Οzu8?? 麞e9DQ߷RX, mvW,f==XfFPV6Mϧ[reyd왌|c_465t0axh.H{i4rH!HVA{䙞c)P ^TD4@2"^N7t牗rΡ^o hfN/=qp8YffF}@?!eG"P(亞8xrqqvι_}+2ZI?gB!Ol{ͣdIIӏŢH^sx9bZoo/z0Ҙ!bPQhW+92R%(L- W8˜;T 1"Yp. 1L>_ 669/Yd++/8'O._{lvͮeٿ~:dToX֮T/-.գG;;寿~lv'&Jp3w>D{|֭Ӎ\.J?̓'[GGJ>>^|(|f9_]On?~E^ŗ𰺻{8/qŋ#v>Ε+sU;amg猱ёzlvlۭTJscc? }b1s^#*~rPŘze1NS T:W |bE8\B*()Lsv&mؠvdP^H6A*^ZY\{㎎tёL&šO3NrVR)ϧggDztyuu\οҟLr9_*_Ӄӹ|>mYN:}{חYzKo>|_fSJivv^[l4ڽ瓓 d2)y6d,T\5yZw޹.,ZܯNOmTw_nbA5p]:wtT eį)cͫByq6X_ CW\lv:t#B C8䖮ݵJY Y|jA̲d^S.RQI)0c;l4ԃ" H]50%8\>2Lg( ^ :<9 -rX,yj3bRnbnfffƎjEzunttSĥK8[ˍFVkEV{啅B!;::ϧwZ.soq1ăKK3ׯϻG;T;Ţt:Ǯ^Ӯ띜 ,M3KSޠo]yK0\cP(d\[\SgfƮ^;<N(mrO>W(d+ϟ7\.Dݧ|zex1h6}xXvODioy8صZ˶Z'w]hgO=mwd$ɖe9f߷Z^3oy}T4VWovgvSD*ʕ 죏Y^ ?ݻϲٔf/o^i4:kbd2Z``x䤱snwv*<(luuX_[Y`_8gmh%ݗ ,ӪxG40%!R2MF\8%ƧtS#SK(1F\P~)8KG,A=Q[ y KMNӧ;##vW''KljRi|\.+LOzg`vv~zib Lʿ Fx4~튿/=(\.88ss''^oN'DZmygrǣT|eE.N&cǟ=i.Ǐ7~+++/O~rgt޻v*췿r͛WV6\NJ 7n\Ō _ (Cs4]1.dw t}1C%L 7$^"Hn j{,M&t&?&ogIMdn`6c_ Q5gWO֧qT ejs9:V`ԁ!@ :>^X+p giRL\. '867Ÿ?>^vϿ4 endstream endobj 164 0 obj << /Type /Annot /Subtype /Link /A 165 0 R /Border [0 0 0] /H /I /Rect [ 284.7323 81.5701 295.5743 91.4907 ] >> endobj 165 0 obj << /Type /Action >> endobj 166 0 obj << /Type /Annot /Subtype /Link /A 167 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 346.8847 240.7500 571.8847 ] >> endobj 167 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/09/polymorphism275y2.png) >> endobj 168 0 obj << /Type /XObject /Subtype /Image /Width 274 /Height 300 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 274 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 554>> stream x1 0 =ol yK’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’+s endstream endobj 169 0 obj << /Type /XObject /Subtype /Image /Width 274 /Height 300 /SMask 168 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 274 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 55844>> stream x}wxTU{eZ&Lz%$PCPQ"E4Qʊ]+쪋(L&L&L\n ɓν=}{A$I$ P{>3%Lҕ;=h|Wo~}UA,B5fqIJPGKr1Ы0Cw?" 젰ք}tNsg ?w.$%S*tP_n4Ptݜwl{fe!SCb:<8xgƑ#WQp;<;f|̤vN;-N)rػwV~LAES[* t~RbCۺǔNgՄx?X~V"r% (n@zA885Sbo\:|t ~AI{JG_٧34ɺO\xIBT_m/Ξ^W$ XVY:#g_8t,)&dqX,x]aMK緗[=Z!4J_8JjS_Lk*9&/;o1UnY^`~b>L2FYw5 ]I&h-S7S9NaJpqtnܻӈ;3.CÕ"I Y׃'9qO ŋ%LlI ==ח$b!5u2X84L%aLJ[ M2sAyw˸38g%N/x$ܻ /WR$SqalkjVD`RDP-:9ٗo4L,9elO,N#"' ow:}@Ź/_H1th:t̶p8.b q'9tќ-tp%=] dF!5.]EN+Iiրq nLN{u]fFP_f檰:Ot@w'7[jS+p߲ =$3gThF0DF&NCDdw0j߆r@`MH语[XlQ*=BB <So/%@$HFޮ ijp||b`B`h`@".롽 `f VTb {>&k2B+~jlI Tj$j%z{b``s86-XD"lin냞Nr Ba2f3!@@T V+x{!@g'dUUkRR$IJD!!X-Xe2~HA&GE \!bFÍ@gXlaI*X. 4,b4^?Tt2, E"ĺt72r 6v@g>Nx^i0E9J iݔ9sphezwҨ:z'h9`sZ$\Ƚ>7e:^^$ObaHG9sֈ ҧn7e.i;ϞYcrf~`/+K79GW "#lx;uZЦ mo潳t AÈűl4q{pH1*ju9X~[1Q>NU*`WtLtI~`#0iҴ;qĉk>#$$0 CPPŋgϞk6:uWVq#=$%KP?Y,˭V+I'jHX,~mbboFcɒ%$I6eΝ{С Nw)~XK\fgϞV`$ 6mlvTh:sSKm I_>|q>ǒ%Kl6ې%K&$<1. ؑ/rѢEɿ# CA̙3Δv7Bgot7tBpɿ#o $T3gJy$IV7k$ 6ܢЏLoF?saX=&[߀ ?ԗ/Q!bPlcX~;G0Ci$IVUUFI 3dJ^bH b}<#GAG!4$lp@o  bYJדRN>;xرc.]~ݮ_R5tf{Ϳ# CV}jjjH$IǓ/꿾-悽;zFF $7..]s͞={td(/? Oվ0nHKK g >,G,fl6[(WVVק544 hɓ' P*͞>k` ^+z-1mrܹ^==hZ[bE^^\esz衃F, #/ Z.vȑM6h@H"?<uLg,hdVƉX,޼y~JX,X,, +͎Dzܹs7o>rȪU Ri0p [,f{DlaBWM/̐8XYo >bތ1AB( 1v/ ns#@V3lW Dr헊@h4U{@((^L43Xp1&t(dJVZڥK$YeK@lٯ+\1DM'yP/| a"dO.bD8zѪMK>7r ^x/D6mݓ cǎ;֭[GcX18[Jg*+ 0w{q I25ZBfN;l4; 6'XJ^ 8`hSV夠h@+jJJ% B뜽d@.!ԡ08(wZ-@)^W%@/&(ph%pQz{^Ǟ<Ǎi3p ߸;xagzz$I6mٲe?,,abtg3g:r{ݟ}YUUU^^P({\|rX|ܹM6lC ̙3*E-^ի|>?:::++A"cJNNV*\.w޽l6{ڴiMMM~~~۷o7ͭ<@|||EEE^^hٴiX,nhhXbEtt4ΦM|}}CCC 0ƍ[vmeeeJJJ@@~ڵ9shHR9k֬ *FxǍWTT)))Jb= %%%~;|䰆vwwm޼… Vfffr܌ Nի'Lޞӳm6Fe˖&ZMiH${gԩW^p8aaa*jӦMUUUT\ؽ{L&[j+++BmۚX,֌38R7o˯\b}Y\钓rfø>.\4iAO=T`` noolmmh4<OP8qf]vMVxС<>{qZm6d2ٳg/^8}3gd2L׿BPb)--<&0;; wQdF6,H$:{lOOǣ΢"4DC1 >>|zLLŋgΜ =z4Ad2eggs8;S*qĉxaÆ>>8T fѣ?b߿|}}91>>/$$E|'+III{KNN5j=f̘#*F=xL>00ڵkGI&I$|||{vv]F#% x\`J˗/ܵkԩSFGGܹSRy{{O<CdYYYHHHddɓRiDDٳg\ \xSNuvvNf\pۊ TQQQj:555555###))iԩ3gΌ  gMvoܸqƌ`EFF$$$dee5*###--m֬Y 777((HP,X ===###..d2@jj̙3-KFFĉGJZzz,fh4NC:::FP(l撀l +((ׯv^2 \BHOOBPp3rwH$ tV}G8SN@:::\ɱX,YYY&iڴiׯ_???^TjX4MXXXoo/LMMh4 ,,X՘K.7nh4 .~:f^ ݿɓ'rѣ{{{ʙVX,ru2 &MDOPyxxXV\kfӏ}jSDhh(^Xߟr7x̙3gk׮mjjƚ3n8Ld+`M$ij˗/111pCPP؋IMjj*Fre@b"IR$<,3000WB]Lk:::t:`{]ۍ7cƌ1ϯZ-*:L tvvnC\.fgg暚*..p%feGGGMM `6Q(,K,KjUU@ /]yommݼy1cobqHHC}7QUX'|;I ,g6cZYYT*o4=<Pr3 AsOwp ݱTfDJdggKRD"'N(SRR9Hx饗wfGQիkjjl6mjE@up& ?$B^v'DUnj0 Gsz PmbA[likk3=`x_~fz}aa'[zΝ;eُ_rI@SNacqA7o.//f\jsY:lFO?HWW_z*?#ώ;:;;fsii)Nxyd2`(--5 blٲ\z(.\طo_\\bijjF{򈈈gyGѭXqX,ToBߟF 2\?0_R; ݩj}uZSSCDeee__Bq \TT2K NSIII 7HQT܃W)ֆ"pʕVVWW??#NMP9sh4:5}td@;~ϝs$9r 8(T{-csO!@yJjq8~ # YÄx<ޝmwb9&"p2JBݸtp8<cQ`l:(Q"20{/I111Ng_t*^__ۂ9mUO}e\F@,9I,{gA*s2Ư}0]1G'D753q*`ZbohDEgؘf>b`dwg8b˛fol,P=q;sg_``2ٿ?J9v. Cns|^t w{|@ P*W^7nZQ(*꯭/Ybtx@yyyYY]wu% ҭ W^yeڌ+Wle 4 vjh4 zѨl6N:NQ Njqg6f@oo/":^dU;TW[Lm6j3f̘c"ܷo_dddqq[o ?0nDM88Zt)>Yf۶m9={,^;vʔ)hG ֮]{wISRRx<^~~>zKPlذg/_<&&&..駟F*񀇏OVuፌ[쌌 Kw}5k 11q߾}G[bELLLDDyP$11CnKzz:&w܁1뮻`ʔ)"(555 Ԧ"+J}tӟ??;622R }:ƢYYY*J,aA"k׮Rhll!!!3gliixw;hiiR4)))66.E\DDĘ1ceG%cGGN?CFĢ'&, }7 ''gǎP\\|) RbQzitJ=zԻ/8 y>hZL4n$I.zIS&sss]DD1_,1jHJIIֱ)66$K⮜Jڸq#ЀK,,, 5jlP˱U;w._PTx5YtB6mVNHFZMM͂ Fchh2p$={>@2ottjdQԯ[;;;`ɒ%XL 628>_[[tRd!ʾZM6uVbb޼yCLZΝ;@*RTqa+h"^]]]AAC疙8xq'L/doN<6Lұ@ @N'\|'222--秧xT\1w۽{7-((@RSggIX'kkksrrpRX__O5ؚ.PѳX,7oW_=V4պ}c"9ȑ#X-KyyvddEvuu!sÆ X{KJJsaaaR w}1ǎsX?onn1POO;+**V+UL}4c?#j>sjԼh8x/\.?ݻhf׮]t](bx(k$04dh4{`8s f3Iz^R3'СC^^^FGMMM_,>S80PT4 ϟ7mڄ\^^$+gl۷otQQQxh4cQ*f˃aErxђM&Sgg{G'⒀K[ӟvڅ$IΘ1`8 EٌAlܸ:Ƅl~饗>'d2uuu9tK,9rK4lo Aoo/u`¸qWL~ͬ܀ w/uTe7G0__w58wOᲷZ"ɡf`q.x4;UvL,@2NٹUC#Fj'Vvj G~vw]5|-*2wFMc5i% d3HsCP }a'̩.`ݬAaLغLoi;: `hQPٚS:tee L:=`+ϰ5Aݻ~d:p]ܜpYml߾iW\gL4BҸA#.@ Jy@ev٫.F3v$>kZf+4\'TP4$Lpꔽڌal'z۫-ݗQ! `f9Y2l=jC}؋+/Xm"#!b(P|4Ci?Xh:8%Rs(Fq`{LY?̝;wcR~/g9e&LNq̉*sԁ[M)DvvW_}~!A_t_G0!X,'|3D"ѯ.@كV9srr"""e2͛JKK'N%J222R\.={… ]6qD__߰0Lvӧ_x133G5&)33333SPL0aժU---+ǫ?~5k_n4m& .\(\nll죏>zu^OΜ9$11QT$9uԐܹs+V0aBQQQppƍu:L&{Γ)===oNDssߟ{ڵYfd̎G}4 vܹsϙ3g|޽{ZL&[pT*{RSS ͛Bacc<]TT$ wddd>>(H,..>qڋ 吐V+8<F{5 Aټ|6oo/_j|>?** 3z/ANdMMMx0?//OVd%$$<7CCC~i`ٗ/_FF$! m@ww7Ex"n-:tRRRgd2Yll,zLIIX,|>?''_~%0ex"3sN:uϞ=\.7$$5~ivvvNN΁(5888;;gԨQaaasaZ|}RݻQ퐐I&=ӘX9o=c HtwPF ?sWX:.>>3722Ndjj*Zҡ]B_f !YKKΝ;O8%1b(755!bŘU 7 Pj*W3MojE ONNR.\kY &ٳg)#6~xe@G d&L@BڤI`R\\;`:,XΝ;4FZrJHLL,\5:t߿I)l6vh&cymjj@?ᅡ$iӦQ&ѴZmtttBBH$Zp!=\.X,l  o&5jT@@ڞ ^dfx TfX,զCȿQ8jHҒo#3>>~ڵ /'4iݩS(B`0`sZ*AAAFخ_TVV`GBkBRQQH<<<ƌ#H0AAAHEEE%''cتU ׷nݺG}T#h4u[gAV=u~~~VU|&LlZӦM2e ގJ$(MZmaoo7 c=\.>$//;@\.O&WTT`ե}}}6l{ߎ6lzE E._|bXxh 6{s?~|GG(v QTo۶ noooqqqTT LMMNDh7ʕ+_www]]|Hջv튎޹s'&=*HN:}v4ݍI$˫Wl[TTW^^T*)]z56%j`A|Mp|9s&Lu-[`:@# @U!G]8?H76iۉv*4Fgoi8˰9h onD sIR?۹s*/0ծD)Bt;Qpnp-NAϵȥ $AOǐh~==^:}b]t3foqc{='LbȲ4̠Wͬ#E nRj&{ R,EF`U;t:gh/8L3`^&,6@w`8Ֆ*\:; (pHԴzv@lM<[2B#C@Y R *COйx= N7MD$'=RlfG)%'N('I(-23'KJ\4؜_%;9hV Szd%pd8f?# L{tt ncC|})Z_f]agaӨqr2aUe&Κhync/5AEsIyC^ՔtL\4P:L40̹H|@}QdD&$sA٦w .\s5A! OTN :WfP +ȵ_TakBp8rw'uP(DCƍ{7ϟꫯΞ=ᄋ~-PlիW]v._oOLLJs^pt hƍw}7zGsիW?C駟{cr]w۷O ݻwu޽R;pԪUp&N0.wGut ?1["_ܹ7]pgnnYV\\?oFJJJff /Īu֭]&O׿ !9`ӦM󋈈x'njf7mڄ.c$,]taaayyyȸ4i<͛鐚;P$0/ Yy=A̜9/eX6m+pv޼yS"4~T{۶myyyw}w||wމA'&&N<$v~z n ފ+rssd/#WW^40arU\ݻ./0 Y,7-,,ϾuQ4EwС߸]M=effxLL/{󱱱&LZ2f{xxL2JOOwPH((((--RRR;|OzHtʕo Ǐ5<((gAĉk7orgW^^V+^o߾>w /pJ뛔$%ɸq0?>CZ'Mpr9F|сtQFq8'>3ׯ_JϟxX8?2&M&̙3;::bU?ه$F#G(۟B+2w,X>Că>x>G*#cҥ̗.%n>xb :%% ~w(d^^oߎa -jooryH|{{{9Ε+W( 4\@{{Ohܹs/BHHJr]]] hD:`TSSѣG;\]UUۋ7zxxh4qơ7.cl6755QrJz Ez3++ ^^^X I!Tݻws\^. bl&{zz֬Yf6\.ϏEMMMqqqب:uJP z"2a,^f ɘ1c b\`V"S16mĒZ^RR {I:utttbPX,jMlŊXѺ]kkkuu5ju 8~8<iiiR,5ј{;/L?7~XL\xM꧞z*))IѴ"1O@OO\7[VVF)F,???XFf۷yPhY(zyyD˖-CV^+==fz*cjȮcǎ9p"_>~xd0Yl6 b```II ŲZ/rKK }嗑@P(p_ǧ*88m'$$L0ۛ=(Pa]R)t: ovV7Ĵ믱qY Kee%p %>V'N𺺺> Jeaa!htܸqǏGW_}u())`Z).rƍ8F4F`ȼ*V!" jN2mgfVKCCCWW뮻JJJ{zz= v֣RܷW*HJJ1J*//V ))))HkmmF <xٳgy؝;wb3YQQuV̳'NzT3p BY[[e,Tm0]]]xEPT`\j#g$͌澺tuuHȉI6yأW^U~kٹsg[[=SSSi&Tքm6tlwKQWTγk׮;ѣUUU<00zݻscǎ]uUt*J\.ްaCCCC(?W\G}_ݴiөS֬Y|ett߿ptvv^wnooO?Oѩk֭ٴiӗ~\L644\Z׮]d|h4C K/"]pUUUﯩinn袋뮦&azX,Dy{U^xsT(JzQ)'*BOL&|PGdgAU6>*]EEr$^'H$r|_jK.744TUU` TrONNjfDW\*dM&/KTQvԩ|׻n:ac"4x`0(/4 <36mj]t "+**t::_F/!hBrhnn~ꩧ@xpOd,3 wvA 7܀K~_TWWkW^y8777>>j-Kcc`P*F5N;H噙't900PVV+@*'GQ?er 㩧B5o^ 6<DE56mÆ *jO>믿NjPÇ755=3Ha1q*Po@4===|݋\&#{zz] o۶mΝPWW*. D^ ȼ (N 7܀۠QN< Q!{E&m۶[UUUp ҂2~TnݺX,/袑`08<<}v0G?B]o_χJx^/:CQ<!T@ *ٞ\B0ɓ'կnذ@ Rݻw$y>R~sC>w}7* r\n}Cʢ].R RD.Z}~z:B4ݻ#JFTU磷 >DyyyEET788J@rV; L&Tʉh3ͳ5 8>,+8q\q5yt:3 nooG5|Ynk4fff6l؀eo~QCKbg,SO󦧧q~3yxv#_p|O?T~aZ媭EV>44TZZ*=c.kʕ5s8(J?W jJbY[dJ.C4Qߠo+.4iFuǏGoE{ ir?'$b̈Zr9uppP(oף~Lvq^Cb`G~ӟ"1==Dj_,‚ZFgr|$Jp&&&JKKq ; ?Uz{Ж;w*t:*" ;tzǎ(۲e˖-[dz衇Pyaa!ٳ\.xvB!xN8QXXH$:Frᶶ6t,v---h4<2Ӿ>effٳ(LOO2SN ok1χRT`;>>/~5;v -E russs=J)gggQ믿3TN)***B a) u],˺\|phh( F͆,?P%z?oH$8333@ ߏNx< FD&UWW{}}}333v766v 7~ai'N@uuuwq_?tP"8r}D,~LO]rh'-W SOK 7mrsܴAhRQޚo2B8_tM {,lxKrq$ܵ乓>˿7f.:&w AI.~;p2CA\ `+9 9CNpK.0D}n@ﯽfU0o}vy:!2T*;+n~.YpK [zfLt: x_Wg+e}[R5k!RP#zZ_`EܷM\F6u:/]ҒH~\U>7P,^wu\ <`EyR-Y0*T`4f. y"BqFJaÆ@~g~@qݺu@ꫯh4;v옙I$7|ݻ;VSSo~gaa[ݻ[[[ovi=NW^y%}oZ֞ok=vn߾};j߾}#GTUUo}Y,~:ٳk۶mVfYf\sp {:;;կ"#t{/:~pGy$OMM=CO޵kח;%'''ۇ>99b[ne0X~[[[.ONNn߾}ppK.]^^nܸqbbvﯬڴiӆ L&*..>u,,,|###**bO8Wj*TD0L]]̌㣡P_2ԷmHH@*FF3g\wuHmr.rT>zFٷoԺС{^z)2xWWv/<22jQ*hm۶3cDf۷oؘF)))!1KKK)B'V8FObkсG(mѤt 8Os 7SžohH$(,--STyyy4EOR{/(kJ¿G}^^ed8|ԷonkkdHtVB4lܸƖ첂ꪫv! ST"H{)۶mғkyTGa@6Dz,ұCG@AA:/ ) w|N''FV+>GvsQ䷦> OO:>t:QȲ:>n>33|S[[t:Q[mh4kcbohhC5rΞ=k64>s VdF.P+`? B/dIH$L`===gxx088.(P(*VT>w̙BގJc_wZfgg{ ^7T!^|Eğ_fBS:44$.E055u1>?ӆa|Doo/c\[]]F_>zߎ츥D} 4٦QK^o DŅhy_~y4M;AeȩT jպ~/UbǏz`0 QMۿb)~ll+H$ۇGW^y%9r[o=z`ooo[[b;>>^WWgwYB'ONN:u qGپ}{ii)I ;;;~>( s=W>Jk,vZ9JuN>Jc)殮.j׾5:;;?#_nd߿PywߍAc^z)Ll6,z Df&GUdr($ /| t6ryyؐ# 4:Oow , r^|+9 x):9r83+~IfۿVQxq} 2GK@4 eSx'Z^@g;3x+es"\|I `;6ɚJa!"@/Di>o|O\C.w;ϴ+}x?m:/w[s0xs ,2;idVZZH4NRDgⳎSNqlkn7zGVf-ğ Wը%U'у wF#LbMM =5lٌ!}ZPtMi@]n[nԩSÉDbttK_UW]uȑtoÑHz/PCCBUVdb}w'|RӵtM&K/VF7|noogY+_ g?k06o|755,o|#??[nAG2ڵ vWXj>#---v{/{4իٳrʾnmaaaz//**zO={NgSSӍ7t:c~C1 }Y.oݺ=~n{W|N駟ve]6446}>ٵkg>?ͩ|7F㝴k?GugffZZZ<Oeet~~;sW⺁?8e-|o`hhhxgx< / 1\^FڊJZmMMϜ9꫸w֖_ T*tҒh|!Z**jRh88tP<WՇF$_yaPAyy9zVR<CygPUoF{{{m6ڵkg?~P[[KӴU(:raPM/Ç~x4M4}7c{\ZZN=y^Tѳ^{ !?c_nƿD[ɁIZ{7d2fD^/:_t:Qt$L]vMOOCğ~ip%%%HgƫWv|̙36)bJOP=\._r]X}g_xݻw>~t#Ԡ,ԥR+ /Qaɓ'Q[oUSSMȾ뮻Ua~H$RRRt:}>oqm]V&ڐ{6tz\.袋6np8PIF~~ʕ * l @)?ّ|g@PʉF:667EQ>-xv;:onnwEVT*Ee~矯kooKP &_UuvvbX,O>>F+hM$ N3"@ӡF)BZ,TTVVvQT՘bd2Y__  i!Gn>Bd2x fffE,F"Q$M%%%Ȏ_|ETVM&S8h4((iQh4>FEh{9֫x饗998'6~ltt4iT N<933 GFFq8W_}3gdccBE5h4J 걱1͆AB (JYE1L~G[n###x6qT0L8FԷ brDmyy9Ze]vȑH$vړ'Oz^XPPO&(RUUUQMyM.bэ7 twwRWLMӛ7oFg>W_}OLOWWwL$ MLLx.@7770˲k֬yw/h4Gbl6o޼v=33ʖRK~%x/M>EP*:XE  S/^4˲4:7r&.|\roVbX{{dx|nnh45vSS_Ds͚5dg?W\YPP֦jwaP+"^DQ_z˖-6Kܹ|q{nOd"7oVAAAkkPGG{82?O\.]PP {zz}pZ /ӧyd2iZ۷lDv{OOGhO֮]{ȑ/iRZZ:<bYvϞ=6nl6VPPt:vFb89j:?!+aXÿ-0g??={0 6:.NnFDBPRt:MӴBH$9kzsSH$rPewMhXeDY62FF@@k4sGs\bXM̋=)_Ot=Rd,V%NVFLeVJ:r d `\̲XsSY.[5Ԟ+inRC]qK:l0ih4@.2AI IJW"W\[L$YV/&@.g"I:=1RÑd-敗_DޮR ^oB[lS]E'gF>Zu_6l2)CgCl45b>5vr?D"Tl͚r¤ӹj|d*{?/UslT2-*@62 PN $~6apݛgFvev?>ݶmMSSDbfarr6? E+VE?<{Ϝ߸6wu:ǽvY.+,kBiݹsLqcxx)(CnwN\Y\UFhje,(ehlb+X}S;vGrd257H>_phhjݺj\?cD"6x8vmcW^wah4ժ}izHEEp:;HGPMMؘhYF/i,tmmi[M )^jH n( -M'"DGYa|.("/H~-N%"ٳ+O cPXojR.kkK m]]y2N&S5k*ZFe&ȾbE!㑑i3 cff|=:55722rY =00kjJgL&ڵf j5,''iFQzl jU}}--}SS078ten.G;:ؘgrrچ<?0--}}Nө}PIo-j655zNB--} F`hhbl3>>x{@duwMMDjzz~ppرD"'N BT:Ot:m(5yyD"vU*E,裶em6s*j'ʢIat:5ֶ䝂,`'Uvf(EP%GxO@fMQˢ?asDͤY63{(6HٕE/LGq^Nj hԳ,g#6\VPVzaXݬPzfbrY[Z m6֭ x"RB^P?6橪r+rR188i6nA%H*әP6ժ5ZriF. ::]QT*ss[R3QbvKoeM$Jbttj5npxg]]Z(`\x<&K*x|kTl6f(\g7m NLlk%(c q/m[1D "DDgRXa",gCRpbd0m6*hLDΕ{0E}gXڤTPcPa< ىOc :fQ+p_RX E :h H5 DFFHF$_#HoJrMe|Ed[oNx"f5nu:5˲DJUKd"FFE)t xq5ŅIy;X"L1bGoq)8( L(1yJLh3R";D~ 7-)qRd2R)40ۇQN%& }^i:Y,^MӉق|RJ(<b`Y6b4av Eu: ls$UB/IΖx{+ZYb2FtX ,'M0ٸ;JE0avpp2vv_|qɓ]_a^D'EA^c>d.bd$ yQ%{&E SK&tw -ʌ%W,aIxJyցqoq4LN:y.UQUWޱ"N?|̎?l$ɨtY;bE\ 7R5!?l X5ZG:glj\f^)//p: \"`[8nHdϲ,08T*61f~vHKSW”) .L'S$=ˑE3ElX( \xaɓϫXVC}}mmP#X$K&S07JZFh"Oд\RXQ899~}Z#QdŠccD"t LNO#ckgĉQ/EA,p35 E}ĄWFc_J,n˜j( Tb)G:BYe*W?1!<3BkTjPӡ|QK=8a]UV ҋK&ʬ8E0@ܘKtOBtA%BF.HVEA0U*iTh\UɑRVZh\VXQDQ7o^TZ״ ^] D,tTTdSPUUVȴiDbZztt FrYQXV-GwB vD2NYa\b@ڃLR3b̞И1 YY lW8(NYȔq!2EW$CpH8Pq h2B,T@j<.2-AѸDzё#F D2aRJ4ꋦM ng)哙r2!hɒxEQ%H|-BaV"5ԑc Y1ZDFrQ8 gqĊen4D L.ڰcl9)R隗*,р"c!g>,K j"1Rwb8^D@2k [#l6inijŒ4sdbY[H&^o LdO 3K;#ږa12%BE9%˘0 Abc9y1BN+d\NK\] Y0* В `nJ;GqeU @LHtlBXd$deH$'} z]D5.; }qH"娥D6@ 8l:0 7;x|>|d{Ê9g iM,4|Gdjf38+ټȵA !> f$&%fV$)$l&dA 6^?+Bn%R^:dki1yu7?MMͅBѦ.QCJ)M)p9%*X86HX6vb0hW((Z8y 'Yk YU (-?JЏ7QApDɐ Z-qFDdb8 '`dJNDJF(B9%N EA p.IJ1(f($[8))1(Iџ+W|>shapP__ڵD1x'S(2:# llfcw"P*+DE,q0gYb0l[aFY?韈·rxF"0†4A{ JB(`Dueibӑ4c9" eU*)Yl`jJrl@ΞL |B!7"KiYdZ +,qڵ2kj*M\Q"с_$f&ȶD}IU we2:vb1!VNcd]]ٳݣ謟h4QV B F*+oIeU*Gv822аBT!WRK2>ŲT"8٢"R`J`ˉX XfX" !hUYRW{ نU:dqd9!P(bEN9u[ՕyJJJJT* <S4qr,͂!땬F(X T,b%?[(Gv!v=mmK.Y?βloX".ɹ@ \QQxxGaEwAEϧXpp;==_QQJu:M"e3L"NcY' \"jGpHR@ ӒlQG6y]L. %a$a٭h,ڬY2 gGE 1q"gpJ2LR3Z+ep.m dC %Б]%HHKt: g3JRIC6fظk`܃3|$Tn †%{$̿mX%҉$c))C)0ry›H ؖ &3 CDo,"'zơhJ5r~L|- K)w`8rN Ap33H3M` fi6Ͱ2e J){[40QҲ4kG!f$' Y|΀h˟r:Y&PMzMl/ d6Uhبݬ\_cn:`BTQ0l0ᔆS&^j5*KO_'򌊂|5pyլjPT"ԔꔴnQ@8e7+IO{bըuez6몍nI{$LQe _kL, rYBBR VCY-fց,<&¦GI'0QD@t΂y! D_^R=f,3bߒXp'&ƀޅ:&ڈ`sIbXK u;4`.DT2c2$9i<,3ZI .}",G"$hJUMٿ7Pva!8D"Ms-@:]Mٙ8w$XTtRvyIYZ2ADͨjM]gr\.Gjs5k*U*:FGgjkKGvRX *ްﴊ99 \H$k&R)nX B OrȄr:iWCB^_hdœ+2QiĢ8^e)UI-l1s$^D)%fȿH %#ѸGJĬ.v@҅%1sYRzY\@%}8T*V,QV(^3?PQQX]jMM`0RUV2YD#./7k %/L奕=.wJݲˀgsYbaTYsOY-ܱ,rc,%=4F,o# n-6ɒ,DӬPgFK!Q#e;$~ ۇ[ s]pOb[jj[.kFz iլl+L[6d)3#6vb,E K$ikٷd d)V H$)'8<Ą6LļrRpYH8 p$PBuS$Nq#\4 mlQB.ChnU'i9vpHYl٦hCН؃e|a+,MIcDU@ҾҎ%âbiwG.*:u/ٗ:V6 Q-F~ א %lR7;6QIΎ";i<%=KwCAl"_@e5].x(Jm}DԜeE#ee&qGrDwM~ވp$+.l^J4S>d)|S%y;IJ𮚈Y22 }$ёL P+ AHQAtOrKE0ɋA #!bD/EQT=$bayJt EA{Pq6a\Ŏx<ɲlq鴾^uUpLOP(j*Y,^[\y5ZS ,tl7Ь<م$74;5sD݌Kd='$s2 ) @lya+"sXb͉:~nӕt=Bb;,5E$ 1 Mr>nDΈOֿf>a)grΐy9Vt eU`dժ9һ\VbnBo\D"YZ+zzsodRmvm\R$Ԍbch%cpkw+sbRI\Y`^V2\Xձ\]((,X>ꂉ(J(L$^S@,֘fa0jHpvrӕ=#$8DŽ枙?-~\7 2jHq jkKgg]v\.[ *+݉Dh!pX\.kIJ'Q(4iA@Og%1Bd,"dH.Y~ٕ 2 "UiCTW2, "DH(H Oq\ 7NQ,҅>4g>)CVhLZ*BTäRjHE.X N0OAk0hџ Z@dn4#"ix~I I`B|HP4(d@QROh a H$* ېP|h`y3HK&Hx`5s P%'b -|nI"w$/,zᖄa P ,X& $Y>x2F2'?$7m3S⍄߬'gn5ىaq@C[e5#HmqYL06AOjN⤊MY?B#ظHG4(&ckf&.XAU`\'XWH-qMJOBI-3]hOip,A C*JJ!Ѥan a";E0S/R* XH *dT0tʪ ptLD n ,42$QH68⤂OH c A#eLFpȲt$ !cAF<#|+).HOx% clh:Ƌl@ԥ*bѨK&S.wb1< @mXJFm,iдq#S!Kمcy gD!#p0,UY\J9W"SH@(r[(I4Pa #%ad\{IA{ p4>_ #8;1OB8, TD^@Hd#`#d&|̧jh4qcUmmؘ9y EO*+sUVݶ'::{{M&/\S! !W *= 'z{;fDf0U$#x XK\}-w=/מZd֢8Dx5bpN" 1<翹Ԏ"uBpb̂IΩBI), *ˬf1"0K6 .ǝ6s۶5FfX,QYY$7k#C'rj/VUwzLmmS.YiL?e^GG=3ӵtw,E }ǏI>t,-h>Fv/B!P'V a'>pAE71-,,ƲE7Bq+]/2 K>G7 t: !qsEÂ<%J9X#%mժ{Q!'0`j+?FVl<P&sLk\U״00;/׮S { ٹqc!4đ"@m'huS)jBv<8:v ᗅMt_wxI6ޥ UrrUW)pKLKɴږ^R7|½p iwQ񤟘8D Q:(FTH<)$H;<Zs9c:1Q0za$/8 gyh.Q%M" oy/SG9O_K/mqX?NqڿKPA CYh0PLSrI9H@f@o_Ysr'M[la}3$µh:,MDd ]mћo^~xiY_)s]8$Sy& Q{ %J#MEQ~@$-BI:˗Dv!2)^"Ε$:(ZC'u>n.vi WH2yJu_7 >h/]S޽gp[+eM&ottE eWUARy8vUYlɔClC;=C,c||I紮J`*[1H ?ImJE"zB(+ݰ=X04D!p nU [yD 7c!t6е(IZoj+" w͛˘$zk9OM1r0 P vZrhT$\-kH[e҆{?x`s7J'&@u&ZEQ|0#h0DZE dO'5n(lp5Q<0 H ɴ"-CP&uIgHD!`׮]$ȒM*-1xPBR@'kM9O6ckO q>qh,3(: Dtա0QWqC0:HW"%L1T;r@ 'Y(P|r.ҹH]S, kPfZ Tj4SwF 4>,@6@=Z%{{#u8QvkϪQ4rXS2 &Qj ,Ò2(3ҎQj22i-3ʠ.bPLD: UZdM&IV]Ymq\v8]-n4U^(xU F&!.&fR%EMp;y_\UIZPms{V~'(܆" ؊ ,tU&j TM8\YJ_K~f%!m!Sa1Q{ͤzpMQ¸z-(14)ʹP(iPкM7 Չ ;wVq>i4ڳcwǛ|& w:H$cDPΎ kŕxPj*;sI3H6Zxʤp54kz0pg9D a+(LeQ) H.Haj JUtvIm@~ 52$KA!Dŋ};Wwv'+PnWIc;bbYUNJ93ݩ҃ssնj;?-끌pΉ84d92D4n1D = !ж.5sPb/j8a D\DTwc8J 3a&C]!Tv14V6.M^vqmm?1X\i6;mӣN\aeL&?6_$19f.ь#+Ie8k;puFyb&qJt:"O[ KVT)Dk"XLJ""JѭpD^³qJGtr%3J+SDPq*~@dL7rɧr9zko)R8RG90!y.P46SV:ctFD& (0  c>hؙ(&m>p-*+ʲPT)L)4 @"m3)j/]d!vJIBH/4B ĤB wTh[j^hQK JLIR*G+HLmۉZ|鐦+$JLӡbJa9yB K"5׸c CT TXAY\ ŗ=ͩa!W?' [xL%7Af 扺׈.zB#C}v8;ZAp˶hv,`\J6ru"1+#-ҹtvsHnGSͳ?t^Y!nd<r)܀tzٱ'O6GF/v:P(ϧwvNjF;ܹW*FŝR$n4ڌV79Y=ǣTb076_}I}li4tr0"p,M$bjOZa\` v >)+&ok4>eUߙ0B #h~lQ3 sJW2jKm=fQ۞VqE0jCf\REeQz4FŨ(}*Hi6^$_sZm&^ov7+Blrm6Vwo/ן͛WQ4T/N۽|>=إRxwdXݻ~~w+ϼD"& " mB5Ԣ4Z Oޭ;z֫WgLYzYX@pG%Ǫ*>Q>)a qFpB (|XʒPxƹ0hjtt-Ʉ8|zo$LN U''KNqq[SSx<:77\8.MG|>=;;N> C/{TGGG]Z۝N_<[,}@5gAM/ 8_^oxDžF9p z}!{W$2M$WM(^"FMD5g l*Ih>vWz+}y)}~0A߅8o^1,QXsX}iyeϳ9vR2~Ť$J*˴bxĽHGl pQ@߲!]S1\T>5|{jhBE@7)0S4%Yil) p"M"MR% N kJ\mQ Wq?*$C`q*`o*f M !U^ry6TJ0ksӐ*Jk7PH(RikČGiK[  tGGi +#2*UYm~yEX"7N<Ѥ lxM&H g7үZBv\1$޵"?y p8mqa>p5?L~npž+Aj~h*éBZ7\+ˆ޿0M#M#/:QY[۽~}B|n6L1*W݁yB6@?>}O}ENOz9<˥XڬZT"NضN'jׯ_ǣ[OrLҲ۷W]g?w2e9Rŋÿ8VT*^;;;x1 孭-uĕ+W=[ȍoMODfʺI <  *Wͬ{D*@JA(Q9A+y?䐤p*ݐ91F |`W 4 N]㱱Z*J^{8jukTޞq.]GLUsk߼FnZtz :~==qc>D,.N͓T*0sN'AgMMWWw}{._ZBD2<>yt:J%N[U.OOOvo4|qp()TCST-G`&'>( x&MʒRs'8}&]c2t)pEP-Jx CeU7 3, +h4˲{A:l6B92 Xg8dGGm CpضX,RD3ضϧ;8xgYN2t{A^y-T4 BfXzh4lvsT8N'tm=_nH$i>rVkjj… a=w>GQMwlOsQ,z3cps'y؀%TZ77BBW(SMc a-M"~V7ڜx$Tj Lh_"U>,NQh5gIR~|Cr@Kx9 `&cbZuF?>E(uup :L5awIۮr@,klNU@>Yspш lk!gM{L4"ً ,ñkp GܲPEnwLƅSq&gLmWJ`Z:|8 6tz7>:WSm48`~˜g'bjӥFM`tBbGYk YM{ҥT橛b#EWV)?VeRڑ ig hhM]41%'Fg4sNڣG?}l{rt|\zu͹񭭣L&g{fftk0K9777V*VǑV*u_w?ޜ9>(UL&H X0r\=nDEɉ%`~@oRX8hkca6U( fwj2/<&@f6Y*Yn;k: ܼk*@6ڼLQcfx 6K)5*G g 3?EӉ_fS4>km;_}8bJ|lv{cP466OOǮmqgfF-O?W(dVV^$1r:t*%uyȌ)߯rZ )ܔMJa(~ G) @  Q4ph)PH [0it R+=BY%81(Z4VThU'xZ!87@yqT>q~+Մ4T+^gd%=`b ĵM'莊ƆrbWw~7[\Siɳ`O&\o‚1hi7-0i!*\Q8Q wa^ TOUM#\Ma?($_n{́ʭ@2m)"EP'GZ>Qo-Ɛńp9A!bhlpbZj`x, u&x+ Tto ߹* t#T]PaVcy) z4)D&Fq0j=yZ$f?=mc'cfgt4w23S#&KT$/?yҒD#q휘 .VՑZt{y< v,_v϶݉LF~ Teҥ)20ӁayF]@n4_}zPPQK疳) (B&6Uc/9*WaFcqv+Z$3J\ZA-B>4r!:SΦpHOMiXgoCM*%' ' @X'-r86o{{bj]NW! +4(5bO4`})U1şGȀeCOae-j)YpN(h$NSPo䆛: b⮨ 5Ղ<*[elq!ܦ^u/!gCPhi"D auH~xF⌚z ?VQi( xH_ZZ&ScI2:P,H{YF:D1ZZ5ӰP*.mY6c, XR/`N,%۹A̝w.' hYhDCĹi`\(&ݛ'\ "uN1Xsi-MJJ PL*18W;5@82J'eT-RPH tV24 05 JJAG!N'_y{Z<55U>88 ~z7wwOgX̦S޻Ç/"U*rj\.93vEN:Bͬr3;m?Ȁ:V#@~ @ G[*9vcW|]"tn4QȰDY_EJ*MA$> bw0hALÐU"#'4ىw1L晊*pmN||P(d76/<{83s]n6ܽ{oaݻ&?NNNNNNFbxh46֡hDdSeDUb]r,H s9J6 Wʿd"Ț1uAk}fВ˨ )cISE,M"a>U"L=Ie:4M<4;::^og;;J<[^(ݼyeb˥\ tWVNNo|t:…hw|z@u76R/#\~KtVtvJ "ONcMڟH8g*LՕ 3j=QJ±~ p_G_;f#F5 (IbXNLo/%?Xl}}嗿g>=F#NFGG-ˎD"猁)5VQc˰?{ dT$SJG^: b"&3tt) 0PP@t Shvm 2Ut>PEra)K)*FG`0L<1]ALSjA!8̻p{-M sz,ky9H8|OB 8 $S{&YNsK?HX0|t˳$59GZ6ȈЂQ2P/wHjr(A69[VW(!wxL E t>Dk729"duDD4Y<p`@StnGB= ;}DZTOM6#0وkr" jMTۂ%q(]\EJzmYAێA H=%-"l GZp: Ӊɤ $$q2$K4B)j`uqz).2E~3tDBP/SFJ"CӫRDå,5 ÁS`K ЏBlo'+rko/N;_HUav$Ÿ=ˌض vFFV+rx/j5:>>x"U.j$>1?:ONON##vż *E"?1?ČKo1#V֤'!49C$E z ReB' P(VlIy`Lqhs|XxU4CץW\yz k+SII4MWԎT?Q*Yi''&{{I jmJ% ͈e/RA>=g*N'l}=}xIJmo-X{t3F W[@Kbwc5fbz`º9X)G//*o W` )z A&OoYDS.b>B45@jkzB_ Oc(Qb\4Xc݆&GM('BpFsk+5;ۭբ=c`,r(c<"^*Y|f559Qo~SOf.\nnx^ŦɤNf3:?߉|c~>"436Tm*MN n1̔=@+I(ylh AAA՘8 oU\;9/,Lݹ׶_b_X<ss E^op hrp=C"v''=ؤLYHqE9G}.1dJ׉i郲DlsD&mgk^oZ55UNhcpw=~92i{~+nyXm۝GHdj[ zK$bKK3H8j7X-Z]_/N f7,޽gϞ펏, ,Bqoz233= n:>c,N,-̈́B,4ݷ߾rx<ҥwwN<ѓG~Dśv0ƺA.99N&{ͦ.\/ض/$^(dv*X,L-۽x<F,ˉFÍFgttu=u?p XގF#D~df2~j6;BVkZ˥^>al_e7d2E;۽r98n$Fшyj\Οzu8?? 麞e9DQ߷RX, mvW,f==XfFPV6Mϧ[reyd왌|c_465t0axh.H{i4rH!HVA{䙞c)P ^TD4@2"^N7t牗rΡ^o hfN/=qp8YffF}@?!eG"P(亞8xrqqvι_}+2ZI?gB!Ol{ͣdIIӏŢH^sx9bZoo/z0Ҙ!bPQhW+92R%(L- W8˜;T 1"Yp. 1L>_ 669/Yd++/8'O._{lvͮeٿ~:dToX֮T/-.գG;;寿~lv'&Jp3w>D{|֭Ӎ\.J?̓'[GGJ>>^|(|f9_]On?~E^ŗ𰺻{8/qŋ#v>Ε+sU;amg猱ёzlvlۭTJscc? }b1s^#*~rPŘze1NS T:W |bE8\B*()Lsv&mؠvdP^H6A*^ZY\{㎎tёL&šO3NrVR)ϧggDztyuu\οҟLr9_*_Ӄӹ|>mYN:}{חYzKo>|_fSJivv^[l4ڽ瓓 d2)y6d,T\5yZw޹.,ZܯNOmTw_nbA5p]:wtT eį)cͫByq6X_ CW\lv:t#B C8䖮ݵJY Y|jA̲d^S.RQI)0c;l4ԃ" H]50%8\>2Lg( ^ :<9 -rX,yj3bRnbnfffƎjEzunttSĥK8[ˍFVkEV{啅B!;::ϧwZ.soq1ăKK3ׯϻG;T;Ţt:Ǯ^Ӯ띜 ,M3KSޠo]yK0\cP(d\[\SgfƮ^;<N(mrO>W(d+ϟ7\.Dݧ|zex1h6}xXvODioy8صZ˶Z'w]hgO=mwd$ɖe9f߷Z^3oy}T4VWovgvSD*ʕ 죏Y^ ?ݻϲٔf/o^i4:kbd2Z``x䤱snwv*<(luuX_[Y`_8gmh%ݗ ,ӪxG40%!R2MF\8%ƧtS#SK(1F\P~)8KG,A=Q[ y KMNӧ;##vW''KljRi|\.+LOzg`vv~zib Lʿ Fx4~튿/=(\.88ss''^oN'DZmygrǣT|eE.N&cǟ=i.Ǐ7~+++/O~rgt޻v*췿r͛WV6\NJ 7n\Ō _ (Cs4]1.dw t}1C%L 7$^"Hn j{,M&t&?&ogIMdn`6c_ Q5gWO֧qT ejs9:V`ԁ!@ :>^X+p giRL\. '867Ÿ?>^vϿ4 endstream endobj 170 0 obj << /Type /Annot /Subtype /Link /A 171 0 R /Border [0 0 0] /H /I /Rect [ 284.7323 81.5701 295.5743 91.4907 ] >> endobj 171 0 obj << /Type /Action >> endobj 172 0 obj << /Type /Annot /Subtype /Link /A 173 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 346.8847 240.7500 571.8847 ] >> endobj 173 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/09/polymorphism275y2.png) >> endobj 174 0 obj << /Type /XObject /Subtype /Image /Width 274 /Height 300 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 274 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 554>> stream x1 0 =ol yK’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’+s endstream endobj 175 0 obj << /Type /XObject /Subtype /Image /Width 274 /Height 300 /SMask 174 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 274 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 55844>> stream x}wxTU{eZ&Lz%$PCPQ"E4Qʊ]+쪋(L&L&L\n ɓν=}{A$I$ P{>3%Lҕ;=h|Wo~}UA,B5fqIJPGKr1Ы0Cw?" 젰ք}tNsg ?w.$%S*tP_n4Ptݜwl{fe!SCb:<8xgƑ#WQp;<;f|̤vN;-N)rػwV~LAES[* t~RbCۺǔNgՄx?X~V"r% (n@zA885Sbo\:|t ~AI{JG_٧34ɺO\xIBT_m/Ξ^W$ XVY:#g_8t,)&dqX,x]aMK緗[=Z!4J_8JjS_Lk*9&/;o1UnY^`~b>L2FYw5 ]I&h-S7S9NaJpqtnܻӈ;3.CÕ"I Y׃'9qO ŋ%LlI ==ח$b!5u2X84L%aLJ[ M2sAyw˸38g%N/x$ܻ /WR$SqalkjVD`RDP-:9ٗo4L,9elO,N#"' ow:}@Ź/_H1th:t̶p8.b q'9tќ-tp%=] dF!5.]EN+Iiրq nLN{u]fFP_f檰:Ot@w'7[jS+p߲ =$3gThF0DF&NCDdw0j߆r@`MH语[XlQ*=BB <So/%@$HFޮ ijp||b`B`h`@".롽 `f VTb {>&k2B+~jlI Tj$j%z{b``s86-XD"lin냞Nr Ba2f3!@@T V+x{!@g'dUUkRR$IJD!!X-Xe2~HA&GE \!bFÍ@gXlaI*X. 4,b4^?Tt2, E"ĺt72r 6v@g>Nx^i0E9J iݔ9sphezwҨ:z'h9`sZ$\Ƚ>7e:^^$ObaHG9sֈ ҧn7e.i;ϞYcrf~`/+K79GW "#lx;uZЦ mo潳t AÈűl4q{pH1*ju9X~[1Q>NU*`WtLtI~`#0iҴ;qĉk>#$$0 CPPŋgϞk6:uWVq#=$%KP?Y,˭V+I'jHX,~mbboFcɒ%$I6eΝ{С Nw)~XK\fgϞV`$ 6mlvTh:sSKm I_>|q>ǒ%Kl6ې%K&$<1. ؑ/rѢEɿ# CA̙3Δv7Bgot7tBpɿ#o $T3gJy$IV7k$ 6ܢЏLoF?saX=&[߀ ?ԗ/Q!bPlcX~;G0Ci$IVUUFI 3dJ^bH b}<#GAG!4$lp@o  bYJדRN>;xرc.]~ݮ_R5tf{Ϳ# CV}jjjH$IǓ/꿾-悽;zFF $7..]s͞={td(/? Oվ0nHKK g >,G,fl6[(WVVק544 hɓ' P*͞>k` ^+z-1mrܹ^==hZ[bE^^\esz衃F, #/ Z.vȑM6h@H"?<uLg,hdVƉX,޼y~JX,X,, +͎Dzܹs7o>rȪU Ri0p [,f{DlaBWM/̐8XYo >bތ1AB( 1v/ ns#@V3lW Dr헊@h4U{@((^L43Xp1&t(dJVZڥK$YeK@lٯ+\1DM'yP/| a"dO.bD8zѪMK>7r ^x/D6mݓ cǎ;֭[GcX18[Jg*+ 0w{q I25ZBfN;l4; 6'XJ^ 8`hSV夠h@+jJJ% B뜽d@.!ԡ08(wZ-@)^W%@/&(ph%pQz{^Ǟ<Ǎi3p ߸;xagzz$I6mٲe?,,abtg3g:r{ݟ}YUUU^^P({\|rX|ܹM6lC ̙3*E-^ի|>?:::++A"cJNNV*\.w޽l6{ڴiMMM~~~۷o7ͭ<@|||EEE^^hٴiX,nhhXbEtt4ΦM|}}CCC 0ƍ[vmeeeJJJ@@~ڵ9shHR9k֬ *FxǍWTT)))Jb= %%%~;|䰆vwwm޼… Vfffr܌ Nի'Lޞӳm6Fe˖&ZMiH${gԩW^p8aaa*jӦMUUUT\ؽ{L&[j+++BmۚX,֌38R7o˯\b}Y\钓rfø>.\4iAO=T`` noolmmh4<OP8qf]vMVxС<>{qZm6d2ٳg/^8}3gd2L׿BPb)--<&0;; wQdF6,H$:{lOOǣ΢"4DC1 >>|zLLŋgΜ =z4Ad2eggs8;S*qĉxaÆ>>8T fѣ?b߿|}}91>>/$$E|'+III{KNN5j=f̘#*F=xL>00ڵkGI&I$|||{vv]F#% x\`J˗/ܵkԩSFGGܹSRy{{O<CdYYYHHHddɓRiDDٳg\ \xSNuvvNf\pۊ TQQQj:555555###))iԩ3gΌ  gMvoܸqƌ`EFF$$$dee5*###--m֬Y 777((HP,X ===###..d2@jj̙3-KFFĉGJZzz,fh4NC:::FP(l撀l +((ׯv^2 \BHOOBPp3rwH$ tV}G8SN@:::\ɱX,YYY&iڴiׯ_???^TjX4MXXXoo/LMMh4 ,,X՘K.7nh4 .~:f^ ݿɓ'rѣ{{{ʙVX,ru2 &MDOPyxxXV\kfӏ}jSDhh(^Xߟr7x̙3gk׮mjjƚ3n8Ld+`M$ij˗/111pCPP؋IMjj*Fre@b"IR$<,3000WB]Lk:::t:`{]ۍ7cƌ1ϯZ-*:L tvvnC\.fgg暚*..p%feGGGMM `6Q(,K,KjUU@ /]yommݼy1cobqHHC}7QUX'|;I ,g6cZYYT*o4=<Pr3 AsOwp ݱTfDJdggKRD"'N(SRR9Hx饗wfGQիkjjl6mjE@up& ?$B^v'DUnj0 Gsz PmbA[likk3=`x_~fz}aa'[zΝ;eُ_rI@SNacqA7o.//f\jsY:lFO?HWW_z*?#ώ;:;;fsii)Nxyd2`(--5 blٲ\z(.\طo_\\bijjF{򈈈gyGѭXqX,ToBߟF 2\?0_R; ݩj}uZSSCDeee__Bq \TT2K NSIII 7HQT܃W)ֆ"pʕVVWW??#NMP9sh4:5}td@;~ϝs$9r 8(T{-csO!@yJjq8~ # YÄx<ޝmwb9&"p2JBݸtp8<cQ`l:(Q"20{/I111Ng_t*^__ۂ9mUO}e\F@,9I,{gA*s2Ư}0]1G'D753q*`ZbohDEgؘf>b`dwg8b˛fol,P=q;sg_``2ٿ?J9v. Cns|^t w{|@ P*W^7nZQ(*꯭/Ybtx@yyyYY]wu% ҭ W^yeڌ+Wle 4 vjh4 zѨl6N:NQ Njqg6f@oo/":^dU;TW[Lm6j3f̘c"ܷo_dddqq[o ?0nDM88Zt)>Yf۶m9={,^;vʔ)hG ֮]{wISRRx<^~~>zKPlذg/_<&&&..駟F*񀇏OVuፌ[쌌 Kw}5k 11q߾}G[bELLLDDyP$11CnKzz:&w܁1뮻`ʔ)"(555 Ԧ"+J}tӟ??;622R }:ƢYYY*J,aA"k׮Rhll!!!3gliixw;hiiR4)))66.E\DDĘ1ceG%cGGN?CFĢ'&, }7 ''gǎP\\|) RbQzitJ=zԻ/8 y>hZL4n$I.zIS&sss]DD1_,1jHJIIֱ)66$K⮜Jڸq#ЀK,,, 5jlP˱U;w._PTx5YtB6mVNHFZMM͂ Fchh2p$={>@2ottjdQԯ[;;;`ɒ%XL 628>_[[tRd!ʾZM6uVbb޼yCLZΝ;@*RTqa+h"^]]]AAC疙8xq'L/doN<6Lұ@ @N'\|'222--秧xT\1w۽{7-((@RSggIX'kkksrrpRX__O5ؚ.PѳX,7oW_=V4պ}c"9ȑ#X-KyyvddEvuu!sÆ X{KJJsaaaR w}1ǎsX?onn1POO;+**V+UL}4c?#j>sjԼh8x/\.?ݻhf׮]t](bx(k$04dh4{`8s f3Iz^R3'СC^^^FGMMM_,>S80PT4 ϟ7mڄ\^^$+gl۷otQQQxh4cQ*f˃aErxђM&Sgg{G'⒀K[ӟvڅ$IΘ1`8 EٌAlܸ:Ƅl~饗>'d2uuu9tK,9rK4lo Aoo/u`¸qWL~ͬ܀ w/uTe7G0__w58wOᲷZ"ɡf`q.x4;UvL,@2NٹUC#Fj'Vvj G~vw]5|-*2wFMc5i% d3HsCP }a'̩.`ݬAaLغLoi;: `hQPٚS:tee L:=`+ϰ5Aݻ~d:p]ܜpYml߾iW\gL4BҸA#.@ Jy@ev٫.F3v$>kZf+4\'TP4$Lpꔽڌal'z۫-ݗQ! `f9Y2l=jC}؋+/Xm"#!b(P|4Ci?Xh:8%Rs(Fq`{LY?̝;wcR~/g9e&LNq̉*sԁ[M)DvvW_}~!A_t_G0!X,'|3D"ѯ.@كV9srr"""e2͛JKK'N%J222R\.={… ]6qD__߰0Lvӧ_x133G5&)33333SPL0aժU---+ǫ?~5k_n4m& .\(\nll죏>zu^OΜ9$11QT$9uԐܹs+V0aBQQQppƍu:L&{Γ)===oNDssߟ{ڵYfd̎G}4 vܹsϙ3g|޽{ZL&[pT*{RSS ͛Bacc<]TT$ wddd>>(H,..>qڋ 吐V+8<F{5 Aټ|6oo/_j|>?** 3z/ANdMMMx0?//OVd%$$<7CCC~i`ٗ/_FF$! m@ww7Ex"n-:tRRRgd2Yll,zLIIX,|>?''_~%0ex"3sN:uϞ=\.7$$5~ivvvNN΁(5888;;gԨQaaasaZ|}RݻQ퐐I&=ӘX9o=c HtwPF ?sWX:.>>3722Ndjj*Zҡ]B_f !YKKΝ;O8%1b(755!bŘU 7 Pj*W3MojE ONNR.\kY &ٳg)#6~xe@G d&L@BڤI`R\\;`:,XΝ;4FZrJHLL,\5:t߿I)l6vh&cymjj@?ᅡ$iӦQ&ѴZmtttBBH$Zp!=\.X,l  o&5jT@@ڞ ^dfx TfX,զCȿQ8jHҒo#3>>~ڵ /'4iݩS(B`0`sZ*AAAFخ_TVV`GBkBRQQH<<<ƌ#H0AAAHEEE%''cتU ׷nݺG}T#h4u[gAV=u~~~VU|&LlZӦM2e ގJ$(MZmaoo7 c=\.>$//;@\.O&WTT`ե}}}6l{ߎ6lzE E._|bXxh 6{s?~|GG(v QTo۶ noooqqqTT LMMNDh7ʕ+_www]]|Hջv튎޹s'&=*HN:}v4ݍI$˫Wl[TTW^^T*)]z56%j`A|Mp|9s&Lu-[`:@# @U!G]8?H76iۉv*4Fgoi8˰9h onD sIR?۹s*/0ծD)Bt;Qpnp-NAϵȥ $AOǐh~==^:}b]t3foqc{='LbȲ4̠Wͬ#E nRj&{ R,EF`U;t:gh/8L3`^&,6@w`8Ֆ*\:; (pHԴzv@lM<[2B#C@Y R *COйx= N7MD$'=RlfG)%'N('I(-23'KJ\4؜_%;9hV Szd%pd8f?# L{tt ncC|})Z_f]agaӨqr2aUe&Κhync/5AEsIyC^ՔtL\4P:L40̹H|@}QdD&$sA٦w .\s5A! OTN :WfP +ȵ_TakBp8rw'uP(DCƍ{7ϟꫯΞ=ᄋ~-PlիW]v._oOLLJs^pt hƍw}7zGsիW?C駟{cr]w۷O ݻwu޽R;pԪUp&N0.wGut ?1["_ܹ7]pgnnYV\\?oFJJJff /Īu֭]&O׿ !9`ӦM󋈈x'njf7mڄ.c$,]taaayyyȸ4i<͛鐚;P$0/ Yy=A̜9/eX6m+pv޼yS"4~T{۶myyyw}w||wމA'&&N<$v~z n ފ+rssd/#WW^40arU\ݻ./0 Y,7-,,ϾuQ4EwС߸]M=effxLL/{󱱱&LZ2f{xxL2JOOwPH((((--RRR;|OzHtʕo Ǐ5<((gAĉk7orgW^^V+^o߾>w /pJ뛔$%ɸq0?>CZ'Mpr9F|сtQFq8'>3ׯ_JϟxX8?2&M&̙3;::bU?ه$F#G(۟B+2w,X>Că>x>G*#cҥ̗.%n>xb :%% ~w(d^^oߎa -jooryH|{{{9Ε+W( 4\@{{Ohܹs/BHHJr]]] hD:`TSSѣG;\]UUۋ7zxxh4qơ7.cl6755QrJz Ez3++ ^^^X I!Tݻws\^. bl&{zz֬Yf6\.ϏEMMMqqqب:uJP z"2a,^f ɘ1c b\`V"S16mĒZ^RR {I:utttbPX,jMlŊXѺ]kkkuu5ju 8~8<iiiR,5ј{;/L?7~XL\xM꧞z*))IѴ"1O@OO\7[VVF)F,???XFf۷yPhY(zyyD˖-CV^+==fz*cjȮcǎ9p"_>~xd0Yl6 b```II ŲZ/rKK }嗑@P(p_ǧ*88m'$$L0ۛ=(Pa]R)t: ovV7Ĵ믱qY Kee%p %>V'N𺺺> Jeaa!htܸqǏGW_}u())`Z).rƍ8F4F`ȼ*V!" jN2mgfVKCCCWW뮻JJJ{zz= v֣RܷW*HJJ1J*//V ))))HkmmF <xٳgy؝;wb3YQQuV̳'NzT3p BY[[e,Tm0]]]xEPT`\j#g$͌澺tuuHȉI6yأW^U~kٹsg[[=SSSi&Tքm6tlwKQWTγk׮;ѣUUU<00zݻscǎ]uUt*J\.ްaCCCC(?W\G}_ݴiөS֬Y|ett߿ptvv^wnooO?Oѩk֭ٴiӗ~\L644\Z׮]d|h4C K/"]pUUUﯩinn袋뮦&azX,Dy{U^xsT(JzQ)'*BOL&|PGdgAU6>*]EEr$^'H$r|_jK.744TUU` TrONNjfDW\*dM&/KTQvԩ|׻n:ac"4x`0(/4 <36mj]t "+**t::_F/!hBrhnn~ꩧ@xpOd,3 wvA 7܀K~_TWWkW^y8777>>j-Kcc`P*F5N;H噙't900PVV+@*'GQ?er 㩧B5o^ 6<DE56mÆ *jO>믿NjPÇ755=3Ha1q*Po@4===|݋\&#{zz] o۶mΝPWW*. D^ ȼ (N 7܀۠QN< Q!{E&m۶[UUUp ҂2~TnݺX,/袑`08<<}v0G?B]o_χJx^/:CQ<!T@ *ٞ\B0ɓ'կnذ@ Rݻw$y>R~sC>w}7* r\n}Cʢ].R RD.Z}~z:B4ݻ#JFTU磷 >DyyyEET788J@rV; L&Tʉh3ͳ5 8>,+8q\q5yt:3 nooG5|Ynk4fff6l؀eo~QCKbg,SO󦧧q~3yxv#_p|O?T~aZ媭EV>44TZZ*=c.kʕ5s8(J?W jJbY[dJ.C4Qߠo+.4iFuǏGoE{ ir?'$b̈Zr9uppP(oף~Lvq^Cb`G~ӟ"1==Dj_,‚ZFgr|$Jp&&&JKKq ; ?Uz{Ж;w*t:*" ;tzǎ(۲e˖-[dz衇Pyaa!ٳ\.xvB!xN8QXXH$:Frᶶ6t,v---h4<2Ӿ>effٳ(LOO2SN ok1χRT`;>>/~5;v -E russs=J)gggQ믿3TN)***B a) u],˺\|phh( F͆,?P%z?oH$8333@ ߏNx< FD&UWW{}}}333v766v 7~ai'N@uuuwq_?tP"8r}D,~LO]rh'-W SOK 7mrsܴAhRQޚo2B8_tM {,lxKrq$ܵ乓>˿7f.:&w AI.~;p2CA\ `+9 9CNpK.0D}n@ﯽfU0o}vy:!2T*;+n~.YpK [zfLt: x_Wg+e}[R5k!RP#zZ_`EܷM\F6u:/]ҒH~\U>7P,^wu\ <`EyR-Y0*T`4f. y"BqFJaÆ@~g~@qݺu@ꫯh4;v옙I$7|ݻ;VSSo~gaa[ݻ[[[ovi=NW^y%}oZ֞ok=vn߾};j߾}#GTUUo}Y,~:ٳk۶mVfYf\sp {:;;կ"#t{/:~pGy$OMM=CO޵kח;%'''ۇ>99b[ne0X~[[[.ONNn߾}ppK.]^^nܸqbbvﯬڴiӆ L&*..>u,,,|###**bO8Wj*TD0L]]̌㣡P_2ԷmHH@*FF3g\wuHmr.rT>zFٷoԺС{^z)2xWWv/<22jQ*hm۶3cDf۷oؘF)))!1KKK)B'V8FObkсG(mѤt 8Os 7SžohH$(,--STyyy4EOR{/(kJ¿G}^^ed8|ԷonkkdHtVB4lܸƖ첂ꪫv! ST"H{)۶mғkyTGa@6Dz,ұCG@AA:/ ) w|N''FV+>GvsQ䷦> OO:>t:QȲ:>n>33|S[[t:Q[mh4kcbohhC5rΞ=k64>s VdF.P+`? B/dIH$L`===gxx088.(P(*VT>w̙BގJc_wZfgg{ ^7T!^|Eğ_fBS:44$.E055u1>?ӆa|Doo/c\[]]F_>zߎ츥D} 4٦QK^o DŅhy_~y4M;AeȩT jպ~/UbǏz`0 QMۿb)~ll+H$ۇGW^y%9r[o=z`ooo[[b;>>^WWgwYB'ONN:u qGپ}{ii)I ;;;~>( s=W>Jk,vZ9JuN>Jc)殮.j׾5:;;?#_nd߿PywߍAc^z)Ll6,z Df&GUdr($ /| t6ryyؐ# 4:Oow , r^|+9 x):9r83+~IfۿVQxq} 2GK@4 eSx'Z^@g;3x+es"\|I `;6ɚJa!"@/Di>o|O\C.w;ϴ+}x?m:/w[s0xs ,2;idVZZH4NRDgⳎSNqlkn7zGVf-ğ Wը%U'у wF#LbMM =5lٌ!}ZPtMi@]n[nԩSÉDbttK_UW]uȑtoÑHz/PCCBUVdb}w'|RӵtM&K/VF7|noogY+_ g?k06o|755,o|#??[nAG2ڵ vWXj>#---v{/{4իٳrʾnmaaaz//**zO={NgSSӍ7t:c~C1 }Y.oݺ=~n{W|N駟ve]6446}>ٵkg>?ͩ|7F㝴k?GugffZZZ<Oeet~~;sW⺁?8e-|o`hhhxgx< / 1\^FڊJZmMMϜ9꫸w֖_ T*tҒh|!Z**jRh88tP<WՇF$_yaPAyy9zVR<CygPUoF{{{m6ڵkg?~P[[KӴU(:raPM/Ç~x4M4}7c{\ZZN=y^Tѳ^{ !?c_nƿD[ɁIZ{7d2fD^/:_t:Qt$L]vMOOCğ~ip%%%HgƫWv|̙36)bJOP=\._r]X}g_xݻw>~t#Ԡ,ԥR+ /Qaɓ'Q[oUSSMȾ뮻Ua~H$RRRt:}>oqm]V&ڐ{6tz\.袋6np8PIF~~ʕ * l @)?ّ|g@PʉF:667EQ>-xv;:onnwEVT*Ee~矯kooKP &_UuvvbX,O>>F+hM$ N3"@ӡF)BZ,TTVVvQT՘bd2Y__  i!Gn>Bd2x fffE,F"Q$M%%%Ȏ_|ETVM&S8h4((iQh4>FEh{9֫x饗998'6~ltt4iT N<933 GFFq8W_}3gdccBE5h4J 걱1͆AB (JYE1L~G[n###x6qT0L8FԷ brDmyy9Ze]vȑH$vړ'Oz^XPPO&(RUUUQMyM.bэ7 twwRWLMӛ7oFg>W_}OLOWWwL$ MLLx.@7770˲k֬yw/h4Gbl6o޼v=33ʖRK~%x/M>EP*:XE  S/^4˲4:7r&.|\roVbX{{dx|nnh45vSS_Ds͚5dg?W\YPP֦jwaP+"^DQ_z˖-6Kܹ|q{nOd"7oVAAAkkPGG{82?O\.]PP {zz}pZ /ӧyd2iZ۷lDv{OOGhO֮]{ȑ/iRZZ:<bYvϞ=6nl6VPPt:vFb89j:?!+aXÿ-0g??={0 6:.NnFDBPRt:MӴBH$9kzsSH$rPewMhXeDY62FF@@k4sGs\bXM̋=)_Ot=Rd,V%NVFLeVJ:r d `\̲XsSY.[5Ԟ+inRC]qK:l0ih4@.2AI IJW"W\[L$YV/&@.g"I:=1RÑd-敗_DޮR ^oB[lS]E'gF>Zu_6l2)CgCl45b>5vr?D"Tl͚r¤ӹj|d*{?/UslT2-*@62 PN $~6apݛgFvev?>ݶmMSSDbfarr6? E+VE?<{Ϝ߸6wu:ǽvY.+,kBiݹsLqcxx)(CnwN\Y\UFhje,(ehlb+X}S;vGrd257H>_phhjݺj\?cD"6x8vmcW^wah4ժ}izHEEp:;HGPMMؘhYF/i,tmmi[M )^jH n( -M'"DGYa|.("/H~-N%"ٳ+O cPXojR.kkK m]]y2N&S5k*ZFe&ȾbE!㑑i3 cff|=:55722rY =00kjJgL&ڵf j5,''iFQzl jU}}--}SS078ten.G;:ؘgrrچ<?0--}}Nө}PIo-j655zNB--} F`hhbl3>>x{@duwMMDjzz~ppرD"'N BT:Ot:m(5yyD"vU*E,裶em6s*j'ʢIat:5ֶ䝂,`'Uvf(EP%GxO@fMQˢ?asDͤY63{(6HٕE/LGq^Nj hԳ,g#6\VPVzaXݬPzfbrY[Z m6֭ x"RB^P?6橪r+rR188i6nA%H*әP6ժ5ZriF. ::]QT*ss[R3QbvKoeM$Jbttj5npxg]]Z(`\x<&K*x|kTl6f(\g7m NLlk%(c q/m[1D "DDgRXa",gCRpbd0m6*hLDΕ{0E}gXڤTPcPa< ىOc :fQ+p_RX E :h H5 DFFHF$_#HoJrMe|Ed[oNx"f5nu:5˲DJUKd"FFE)t xq5ŅIy;X"L1bGoq)8( L(1yJLh3R";D~ 7-)qRd2R)40ۇQN%& }^i:Y,^MӉق|RJ(<b`Y6b4av Eu: ls$UB/IΖx{+ZYb2FtX ,'M0ٸ;JE0avpp2vv_|qɓ]_a^D'EA^c>d.bd$ yQ%{&E SK&tw -ʌ%W,aIxJyցqoq4LN:y.UQUWޱ"N?|̎?l$ɨtY;bE\ 7R5!?l X5ZG:glj\f^)//p: \"`[8nHdϲ,08T*61f~vHKSW”) .L'S$=ˑE3ElX( \xaɓϫXVC}}mmP#X$K&S07JZFh"Oд\RXQ899~}Z#QdŠccD"t LNO#ckgĉQ/EA,p35 E}ĄWFc_J,n˜j( Tb)G:BYe*W?1!<3BkTjPӡ|QK=8a]UV ҋK&ʬ8E0@ܘKtOBtA%BF.HVEA0U*iTh\UɑRVZh\VXQDQ7o^TZ״ ^] D,tTTdSPUUVȴiDbZztt FrYQXV-GwB vD2NYa\b@ڃLR3b̞И1 YY lW8(NYȔq!2EW$CpH8Pq h2B,T@j<.2-AѸDzё#F D2aRJ4ꋦM ng)哙r2!hɒxEQ%H|-BaV"5ԑc Y1ZDFrQ8 gqĊen4D L.ڰcl9)R隗*,р"c!g>,K j"1Rwb8^D@2k [#l6inijŒ4sdbY[H&^o LdO 3K;#ږa12%BE9%˘0 Abc9y1BN+d\NK\] Y0* В `nJ;GqeU @LHtlBXd$deH$'} z]D5.; }qH"娥D6@ 8l:0 7;x|>|d{Ê9g iM,4|Gdjf38+ټȵA !> f$&%fV$)$l&dA 6^?+Bn%R^:dki1yu7?MMͅBѦ.QCJ)M)p9%*X86HX6vb0hW((Z8y 'Yk YU (-?JЏ7QApDɐ Z-qFDdb8 '`dJNDJF(B9%N EA p.IJ1(f($[8))1(Iџ+W|>shapP__ڵD1x'S(2:# llfcw"P*+DE,q0gYb0l[aFY?韈·rxF"0†4A{ JB(`Dueibӑ4c9" eU*)Yl`jJrl@ΞL |B!7"KiYdZ +,qڵ2kj*M\Q"с_$f&ȶD}IU we2:vb1!VNcd]]ٳݣ謟h4QV B F*+oIeU*Gv822аBT!WRK2>ŲT"8٢"R`J`ˉX XfX" !hUYRW{ نU:dqd9!P(bEN9u[ՕyJJJJT* <S4qr,͂!땬F(X T,b%?[(Gv!v=mmK.Y?βloX".ɹ@ \QQxxGaEwAEϧXpp;==_QQJu:M"e3L"NcY' \"jGpHR@ ӒlQG6y]L. %a$a٭h,ڬY2 gGE 1q"gpJ2LR3Z+ep.m dC %Б]%HHKt: g3JRIC6fظk`܃3|$Tn †%{$̿mX%҉$c))C)0ry›H ؖ &3 CDo,"'zơhJ5r~L|- K)w`8rN Ap33H3M` fi6Ͱ2e J){[40QҲ4kG!f$' Y|΀h˟r:Y&PMzMl/ d6Uhبݬ\_cn:`BTQ0l0ᔆS&^j5*KO_'򌊂|5pyլjPT"ԔꔴnQ@8e7+IO{bըuez6몍nI{$LQe _kL, rYBBR VCY-fց,<&¦GI'0QD@t΂y! D_^R=f,3bߒXp'&ƀޅ:&ڈ`sIbXK u;4`.DT2c2$9i<,3ZI .}",G"$hJUMٿ7Pva!8D"Ms-@:]Mٙ8w$XTtRvyIYZ2ADͨjM]gr\.Gjs5k*U*:FGgjkKGvRX *ްﴊ99 \H$k&R)nX B OrȄr:iWCB^_hdœ+2QiĢ8^e)UI-l1s$^D)%fȿH %#ѸGJĬ.v@҅%1sYRzY\@%}8T*V,QV(^3?PQQX]jMM`0RUV2YD#./7k %/L奕=.wJݲˀgsYbaTYsOY-ܱ,rc,%=4F,o# n-6ɒ,DӬPgFK!Q#e;$~ ۇ[ s]pOb[jj[.kFz iլl+L[6d)3#6vb,E K$ikٷd d)V H$)'8<Ą6LļrRpYH8 p$PBuS$Nq#\4 mlQB.ChnU'i9vpHYl٦hCН؃e|a+,MIcDU@ҾҎ%âbiwG.*:u/ٗ:V6 Q-F~ א %lR7;6QIΎ";i<%=KwCAl"_@e5].x(Jm}DԜeE#ee&qGrDwM~ވp$+.l^J4S>d)|S%y;IJ𮚈Y22 }$ёL P+ AHQAtOrKE0ɋA #!bD/EQT=$bayJt EA{Pq6a\Ŏx<ɲlq鴾^uUpLOP(j*Y,^[\y5ZS ,tl7Ь<م$74;5sD݌Kd='$s2 ) @lya+"sXb͉:~nӕt=Bb;,5E$ 1 Mr>nDΈOֿf>a)grΐy9Vt eU`dժ9һ\VbnBo\D"YZ+zzsodRmvm\R$Ԍbch%cpkw+sbRI\Y`^V2\Xձ\]((,X>ꂉ(J(L$^S@,֘fa0jHpvrӕ=#$8DŽ枙?-~\7 2jHq jkKgg]v\.[ *+݉Dh!pX\.kIJ'Q(4iA@Og%1Bd,"dH.Y~ٕ 2 "UiCTW2, "DH(H Oq\ 7NQ,҅>4g>)CVhLZ*BTäRjHE.X N0OAk0hџ Z@dn4#"ix~I I`B|HP4(d@QROh a H$* ېP|h`y3HK&Hx`5s P%'b -|nI"w$/,zᖄa P ,X& $Y>x2F2'?$7m3S⍄߬'gn5ىaq@C[e5#HmqYL06AOjN⤊MY?B#ظHG4(&ckf&.XAU`\'XWH-qMJOBI-3]hOip,A C*JJ!Ѥan a";E0S/R* XH *dT0tʪ ptLD n ,42$QH68⤂OH c A#eLFpȲt$ !cAF<#|+).HOx% clh:Ƌl@ԥ*bѨK&S.wb1< @mXJFm,iдq#S!Kمcy gD!#p0,UY\J9W"SH@(r[(I4Pa #%ad\{IA{ p4>_ #8;1OB8, TD^@Hd#`#d&|̧jh4qcUmmؘ9y EO*+sUVݶ'::{{M&/\S! !W *= 'z{;fDf0U$#x XK\}-w=/מZd֢8Dx5bpN" 1<翹Ԏ"uBpb̂IΩBI), *ˬf1"0K6 .ǝ6s۶5FfX,QYY$7k#C'rj/VUwzLmmS.YiL?e^GG=3ӵtw,E }ǏI>t,-h>Fv/B!P'V a'>pAE71-,,ƲE7Bq+]/2 K>G7 t: !qsEÂ<%J9X#%mժ{Q!'0`j+?FVl<P&sLk\U״00;/׮S { ٹqc!4đ"@m'huS)jBv<8:v ᗅMt_wxI6ޥ UrrUW)pKLKɴږ^R7|½p iwQ񤟘8D Q:(FTH<)$H;<Zs9c:1Q0za$/8 gyh.Q%M" oy/SG9O_K/mqX?NqڿKPA CYh0PLSrI9H@f@o_Ysr'M[la}3$µh:,MDd ]mћo^~xiY_)s]8$Sy& Q{ %J#MEQ~@$-BI:˗Dv!2)^"Ε$:(ZC'u>n.vi WH2yJu_7 >h/]S޽gp[+eM&ottE eWUARy8vUYlɔClC;=C,c||I紮J`*[1H ?ImJE"zB(+ݰ=X04D!p nU [yD 7c!t6е(IZoj+" w͛˘$zk9OM1r0 P vZrhT$\-kH[e҆{?x`s7J'&@u&ZEQ|0#h0DZE dO'5n(lp5Q<0 H ɴ"-CP&uIgHD!`׮]$ȒM*-1xPBR@'kM9O6ckO q>qh,3(: Dtա0QWqC0:HW"%L1T;r@ 'Y(P|r.ҹH]S, kPfZ Tj4SwF 4>,@6@=Z%{{#u8QvkϪQ4rXS2 &Qj ,Ò2(3ҎQj22i-3ʠ.bPLD: UZdM&IV]Ymq\v8]-n4U^(xU F&!.&fR%EMp;y_\UIZPms{V~'(܆" ؊ ,tU&j TM8\YJ_K~f%!m!Sa1Q{ͤzpMQ¸z-(14)ʹP(iPкM7 Չ ;wVq>i4ڳcwǛ|& w:H$cDPΎ kŕxPj*;sI3H6Zxʤp54kz0pg9D a+(LeQ) H.Haj JUtvIm@~ 52$KA!Dŋ};Wwv'+PnWIc;bbYUNJ93ݩ҃ssնj;?-끌pΉ84d92D4n1D = !ж.5sPb/j8a D\DTwc8J 3a&C]!Tv14V6.M^vqmm?1X\i6;mӣN\aeL&?6_$19f.ь#+Ie8k;puFyb&qJt:"O[ KVT)Dk"XLJ""JѭpD^³qJGtr%3J+SDPq*~@dL7rɧr9zko)R8RG90!y.P46SV:ctFD& (0  c>hؙ(&m>p-*+ʲPT)L)4 @"m3)j/]d!vJIBH/4B ĤB wTh[j^hQK JLIR*G+HLmۉZ|鐦+$JLӡbJa9yB K"5׸c CT TXAY\ ŗ=ͩa!W?' [xL%7Af 扺׈.zB#C}v8;ZAp˶hv,`\J6ru"1+#-ҹtvsHnGSͳ?t^Y!nd<r)܀tzٱ'O6GF/v:P(ϧwvNjF;ܹW*FŝR$n4ڌV79Y=ǣTb076_}I}li4tr0"p,M$bjOZa\` v >)+&ok4>eUߙ0B #h~lQ3 sJW2jKm=fQ۞VqE0jCf\REeQz4FŨ(}*Hi6^$_sZm&^ov7+Blrm6Vwo/ן͛WQ4T/N۽|>=إRxwdXݻ~~w+ϼD"& " mB5Ԣ4Z Oޭ;z֫WgLYzYX@pG%Ǫ*>Q>)a qFpB (|XʒPxƹ0hjtt-Ʉ8|zo$LN U''KNqq[SSx<:77\8.MG|>=;;N> C/{TGGG]Z۝N_<[,}@5gAM/ 8_^oxDžF9p z}!{W$2M$WM(^"FMD5g l*Ih>vWz+}y)}~0A߅8o^1,QXsX}iyeϳ9vR2~Ť$J*˴bxĽHGl pQ@߲!]S1\T>5|{jhBE@7)0S4%Yil) p"M"MR% N kJ\mQ Wq?*$C`q*`o*f M !U^ry6TJ0ksӐ*Jk7PH(RikČGiK[  tGGi +#2*UYm~yEX"7N<Ѥ lxM&H g7үZBv\1$޵"?y p8mqa>p5?L~npž+Aj~h*éBZ7\+ˆ޿0M#M#/:QY[۽~}B|n6L1*W݁yB6@?>}O}ENOz9<˥XڬZT"NضN'jׯ_ǣ[OrLҲ۷W]g?w2e9Rŋÿ8VT*^;;;x1 孭-uĕ+W=[ȍoMODfʺI <  *Wͬ{D*@JA(Q9A+y?䐤p*ݐ91F |`W 4 N]㱱Z*J^{8jukTޞq.]GLUsk߼FnZtz :~==qc>D,.N͓T*0sN'AgMMWWw}{._ZBD2<>yt:J%N[U.OOOvo4|qp()TCST-G`&'>( x&MʒRs'8}&]c2t)pEP-Jx CeU7 3, +h4˲{A:l6B92 Xg8dGGm CpضX,RD3ضϧ;8xgYN2t{A^y-T4 BfXzh4lvsT8N'tm=_nH$i>rVkjj… a=w>GQMwlOsQ,z3cps'y؀%TZ77BBW(SMc a-M"~V7ڜx$Tj Lh_"U>,NQh5gIR~|Cr@Kx9 `&cbZuF?>E(uup :L5awIۮr@,klNU@>Yspш lk!gM{L4"ً ,ñkp GܲPEnwLƅSq&gLmWJ`Z:|8 6tz7>:WSm48`~˜g'bjӥFM`tBbGYk YM{ҥT橛b#EWV)?VeRڑ ig hhM]41%'Fg4sNڣG?}l{rt|\zu͹񭭣L&g{fftk0K9777V*VǑV*u_w?ޜ9>(UL&H X0r\=nDEɉ%`~@oRX8hkca6U( fwj2/<&@f6Y*Yn;k: ܼk*@6ڼLQcfx 6K)5*G g 3?EӉ_fS4>km;_}8bJ|lv{cP466OOǮmqgfF-O?W(dVV^$1r:t*%uyȌ)߯rZ )ܔMJa(~ G) @  Q4ph)PH [0it R+=BY%81(Z4VThU'xZ!87@yqT>q~+Մ4T+^gd%=`b ĵM'莊ƆrbWw~7[\Siɳ`O&\o‚1hi7-0i!*\Q8Q wa^ TOUM#\Ma?($_n{́ʭ@2m)"EP'GZ>Qo-Ɛńp9A!bhlpbZj`x, u&x+ Tto ߹* t#T]PaVcy) z4)D&Fq0j=yZ$f?=mc'cfgt4w23S#&KT$/?yҒD#q휘 .VՑZt{y< v,_v϶݉LF~ Teҥ)20ӁayF]@n4_}zPPQK疳) (B&6Uc/9*WaFcqv+Z$3J\ZA-B>4r!:SΦpHOMiXgoCM*%' ' @X'-r86o{{bj]NW! +4(5bO4`})U1şGȀeCOae-j)YpN(h$NSPo䆛: b⮨ 5Ղ<*[elq!ܦ^u/!gCPhi"D auH~xF⌚z ?VQi( xH_ZZ&ScI2:P,H{YF:D1ZZ5ӰP*.mY6c, XR/`N,%۹A̝w.' hYhDCĹi`\(&ݛ'\ "uN1Xsi-MJJ PL*18W;5@82J'eT-RPH tV24 05 JJAG!N'_y{Z<55U>88 ~z7wwOgX̦S޻Ç/"U*rj\.93vEN:Bͬr3;m?Ȁ:V#@~ @ G[*9vcW|]"tn4QȰDY_EJ*MA$> bw0hALÐU"#'4ىw1L晊*pmN||P(d76/<{83s]n6ܽ{oaݻ&?NNNNNNFbxh46֡hDdSeDUb]r,H s9J6 Wʿd"Ț1uAk}fВ˨ )cISE,M"a>U"L=Ie:4M<4;::^og;;J<[^(ݼyeb˥\ tWVNNo|t:…hw|z@u76R/#\~KtVtvJ "ONcMڟH8g*LՕ 3j=QJ±~ p_G_;f#F5 (IbXNLo/%?Xl}}嗿g>=F#NFGG-ˎD"猁)5VQc˰?{ dT$SJG^: b"&3tt) 0PP@t Shvm 2Ut>PEra)K)*FG`0L<1]ALSjA!8̻p{-M sz,ky9H8|OB 8 $S{&YNsK?HX0|t˳$59GZ6ȈЂQ2P/wHjr(A69[VW(!wxL E t>Dk729"duDD4Y<p`@StnGB= ;}DZTOM6#0وkr" jMTۂ%q(]\EJzmYAێA H=%-"l GZp: Ӊɤ $$q2$K4B)j`uqz).2E~3tDBP/SFJ"CӫRDå,5 ÁS`K ЏBlo'+rko/N;_HUav$Ÿ=ˌض vFFV+rx/j5:>>x"U.j$>1?:ONON##vż *E"?1?ČKo1#V֤'!49C$E z ReB' P(VlIy`Lqhs|XxU4CץW\yz k+SII4MWԎT?Q*Yi''&{{I jmJ% ͈e/RA>=g*N'l}=}xIJmo-X{t3F W[@Kbwc5fbz`º9X)G//*o W` )z A&OoYDS.b>B45@jkzB_ Oc(Qb\4Xc݆&GM('BpFsk+5;ۭբ=c`,r(c<"^*Y|f559Qo~SOf.\nnx^ŦɤNf3:?߉|c~>"436Tm*MN n1̔=@+I(ylh AAA՘8 oU\;9/,Lݹ׶_b_X<ss E^op hrp=C"v''=ؤLYHqE9G}.1dJ׉i郲DlsD&mgk^oZ55UNhcpw=~92i{~+nyXm۝GHdj[ zK$bKK3H8j7X-Z]_/N f7,޽gϞ펏, ,Bqoz233= n:>c,N,-̈́B,4ݷ߾rx<ҥwwN<ѓG~Dśv0ƺA.99N&{ͦ.\/ض/$^(dv*X,L-۽x<F,ˉFÍFgttu=u?p XގF#D~df2~j6;BVkZ˥^>al_e7d2E;۽r98n$Fшyj\Οzu8?? 麞e9DQ߷RX, mvW,f==XfFPV6Mϧ[reyd왌|c_465t0axh.H{i4rH!HVA{䙞c)P ^TD4@2"^N7t牗rΡ^o hfN/=qp8YffF}@?!eG"P(亞8xrqqvι_}+2ZI?gB!Ol{ͣdIIӏŢH^sx9bZoo/z0Ҙ!bPQhW+92R%(L- W8˜;T 1"Yp. 1L>_ 669/Yd++/8'O._{lvͮeٿ~:dToX֮T/-.գG;;寿~lv'&Jp3w>D{|֭Ӎ\.J?̓'[GGJ>>^|(|f9_]On?~E^ŗ𰺻{8/qŋ#v>Ε+sU;amg猱ёzlvlۭTJscc? }b1s^#*~rPŘze1NS T:W |bE8\B*()Lsv&mؠvdP^H6A*^ZY\{㎎tёL&šO3NrVR)ϧggDztyuu\οҟLr9_*_Ӄӹ|>mYN:}{חYzKo>|_fSJivv^[l4ڽ瓓 d2)y6d,T\5yZw޹.,ZܯNOmTw_nbA5p]:wtT eį)cͫByq6X_ CW\lv:t#B C8䖮ݵJY Y|jA̲d^S.RQI)0c;l4ԃ" H]50%8\>2Lg( ^ :<9 -rX,yj3bRnbnfffƎjEzunttSĥK8[ˍFVkEV{啅B!;::ϧwZ.soq1ăKK3ׯϻG;T;Ţt:Ǯ^Ӯ띜 ,M3KSޠo]yK0\cP(d\[\SgfƮ^;<N(mrO>W(d+ϟ7\.Dݧ|zex1h6}xXvODioy8صZ˶Z'w]hgO=mwd$ɖe9f߷Z^3oy}T4VWovgvSD*ʕ 죏Y^ ?ݻϲٔf/o^i4:kbd2Z``x䤱snwv*<(luuX_[Y`_8gmh%ݗ ,ӪxG40%!R2MF\8%ƧtS#SK(1F\P~)8KG,A=Q[ y KMNӧ;##vW''KljRi|\.+LOzg`vv~zib Lʿ Fx4~튿/=(\.88ss''^oN'DZmygrǣT|eE.N&cǟ=i.Ǐ7~+++/O~rgt޻v*췿r͛WV6\NJ 7n\Ō _ (Cs4]1.dw t}1C%L 7$^"Hn j{,M&t&?&ogIMdn`6c_ Q5gWO֧qT ejs9:V`ԁ!@ :>^X+p giRL\. '867Ÿ?>^vϿ4 endstream endobj 176 0 obj << /Type /Annot /Subtype /Link /A 177 0 R /Border [0 0 0] /H /I /Rect [ 284.7323 81.5701 295.5743 91.4907 ] >> endobj 177 0 obj << /Type /Action >> endobj 178 0 obj << /Type /XObject /Subtype /Image /Width 274 /Height 300 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 274 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 554>> stream x1 0 =ol yK’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’$, K’+s endstream endobj 179 0 obj << /Type /XObject /Subtype /Image /Width 274 /Height 300 /SMask 178 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 274 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 55844>> stream x}wxTU{eZ&Lz%$PCPQ"E4Qʊ]+쪋(L&L&L\n ɓν=}{A$I$ P{>3%Lҕ;=h|Wo~}UA,B5fqIJPGKr1Ы0Cw?" 젰ք}tNsg ?w.$%S*tP_n4Ptݜwl{fe!SCb:<8xgƑ#WQp;<;f|̤vN;-N)rػwV~LAES[* t~RbCۺǔNgՄx?X~V"r% (n@zA885Sbo\:|t ~AI{JG_٧34ɺO\xIBT_m/Ξ^W$ XVY:#g_8t,)&dqX,x]aMK緗[=Z!4J_8JjS_Lk*9&/;o1UnY^`~b>L2FYw5 ]I&h-S7S9NaJpqtnܻӈ;3.CÕ"I Y׃'9qO ŋ%LlI ==ח$b!5u2X84L%aLJ[ M2sAyw˸38g%N/x$ܻ /WR$SqalkjVD`RDP-:9ٗo4L,9elO,N#"' ow:}@Ź/_H1th:t̶p8.b q'9tќ-tp%=] dF!5.]EN+Iiրq nLN{u]fFP_f檰:Ot@w'7[jS+p߲ =$3gThF0DF&NCDdw0j߆r@`MH语[XlQ*=BB <So/%@$HFޮ ijp||b`B`h`@".롽 `f VTb {>&k2B+~jlI Tj$j%z{b``s86-XD"lin냞Nr Ba2f3!@@T V+x{!@g'dUUkRR$IJD!!X-Xe2~HA&GE \!bFÍ@gXlaI*X. 4,b4^?Tt2, E"ĺt72r 6v@g>Nx^i0E9J iݔ9sphezwҨ:z'h9`sZ$\Ƚ>7e:^^$ObaHG9sֈ ҧn7e.i;ϞYcrf~`/+K79GW "#lx;uZЦ mo潳t AÈűl4q{pH1*ju9X~[1Q>NU*`WtLtI~`#0iҴ;qĉk>#$$0 CPPŋgϞk6:uWVq#=$%KP?Y,˭V+I'jHX,~mbboFcɒ%$I6eΝ{С Nw)~XK\fgϞV`$ 6mlvTh:sSKm I_>|q>ǒ%Kl6ې%K&$<1. ؑ/rѢEɿ# CA̙3Δv7Bgot7tBpɿ#o $T3gJy$IV7k$ 6ܢЏLoF?saX=&[߀ ?ԗ/Q!bPlcX~;G0Ci$IVUUFI 3dJ^bH b}<#GAG!4$lp@o  bYJדRN>;xرc.]~ݮ_R5tf{Ϳ# CV}jjjH$IǓ/꿾-悽;zFF $7..]s͞={td(/? Oվ0nHKK g >,G,fl6[(WVVק544 hɓ' P*͞>k` ^+z-1mrܹ^==hZ[bE^^\esz衃F, #/ Z.vȑM6h@H"?<uLg,hdVƉX,޼y~JX,X,, +͎Dzܹs7o>rȪU Ri0p [,f{DlaBWM/̐8XYo >bތ1AB( 1v/ ns#@V3lW Dr헊@h4U{@((^L43Xp1&t(dJVZڥK$YeK@lٯ+\1DM'yP/| a"dO.bD8zѪMK>7r ^x/D6mݓ cǎ;֭[GcX18[Jg*+ 0w{q I25ZBfN;l4; 6'XJ^ 8`hSV夠h@+jJJ% B뜽d@.!ԡ08(wZ-@)^W%@/&(ph%pQz{^Ǟ<Ǎi3p ߸;xagzz$I6mٲe?,,abtg3g:r{ݟ}YUUU^^P({\|rX|ܹM6lC ̙3*E-^ի|>?:::++A"cJNNV*\.w޽l6{ڴiMMM~~~۷o7ͭ<@|||EEE^^hٴiX,nhhXbEtt4ΦM|}}CCC 0ƍ[vmeeeJJJ@@~ڵ9shHR9k֬ *FxǍWTT)))Jb= %%%~;|䰆vwwm޼… Vfffr܌ Nի'Lޞӳm6Fe˖&ZMiH${gԩW^p8aaa*jӦMUUUT\ؽ{L&[j+++BmۚX,֌38R7o˯\b}Y\钓rfø>.\4iAO=T`` noolmmh4<OP8qf]vMVxС<>{qZm6d2ٳg/^8}3gd2L׿BPb)--<&0;; wQdF6,H$:{lOOǣ΢"4DC1 >>|zLLŋgΜ =z4Ad2eggs8;S*qĉxaÆ>>8T fѣ?b߿|}}91>>/$$E|'+III{KNN5j=f̘#*F=xL>00ڵkGI&I$|||{vv]F#% x\`J˗/ܵkԩSFGGܹSRy{{O<CdYYYHHHddɓRiDDٳg\ \xSNuvvNf\pۊ TQQQj:555555###))iԩ3gΌ  gMvoܸqƌ`EFF$$$dee5*###--m֬Y 777((HP,X ===###..d2@jj̙3-KFFĉGJZzz,fh4NC:::FP(l撀l +((ׯv^2 \BHOOBPp3rwH$ tV}G8SN@:::\ɱX,YYY&iڴiׯ_???^TjX4MXXXoo/LMMh4 ,,X՘K.7nh4 .~:f^ ݿɓ'rѣ{{{ʙVX,ru2 &MDOPyxxXV\kfӏ}jSDhh(^Xߟr7x̙3gk׮mjjƚ3n8Ld+`M$ij˗/111pCPP؋IMjj*Fre@b"IR$<,3000WB]Lk:::t:`{]ۍ7cƌ1ϯZ-*:L tvvnC\.fgg暚*..p%feGGGMM `6Q(,K,KjUU@ /]yommݼy1cobqHHC}7QUX'|;I ,g6cZYYT*o4=<Pr3 AsOwp ݱTfDJdggKRD"'N(SRR9Hx饗wfGQիkjjl6mjE@up& ?$B^v'DUnj0 Gsz PmbA[likk3=`x_~fz}aa'[zΝ;eُ_rI@SNacqA7o.//f\jsY:lFO?HWW_z*?#ώ;:;;fsii)Nxyd2`(--5 blٲ\z(.\طo_\\bijjF{򈈈gyGѭXqX,ToBߟF 2\?0_R; ݩj}uZSSCDeee__Bq \TT2K NSIII 7HQT܃W)ֆ"pʕVVWW??#NMP9sh4:5}td@;~ϝs$9r 8(T{-csO!@yJjq8~ # YÄx<ޝmwb9&"p2JBݸtp8<cQ`l:(Q"20{/I111Ng_t*^__ۂ9mUO}e\F@,9I,{gA*s2Ư}0]1G'D753q*`ZbohDEgؘf>b`dwg8b˛fol,P=q;sg_``2ٿ?J9v. Cns|^t w{|@ P*W^7nZQ(*꯭/Ybtx@yyyYY]wu% ҭ W^yeڌ+Wle 4 vjh4 zѨl6N:NQ Njqg6f@oo/":^dU;TW[Lm6j3f̘c"ܷo_dddqq[o ?0nDM88Zt)>Yf۶m9={,^;vʔ)hG ֮]{wISRRx<^~~>zKPlذg/_<&&&..駟F*񀇏OVuፌ[쌌 Kw}5k 11q߾}G[bELLLDDyP$11CnKzz:&w܁1뮻`ʔ)"(555 Ԧ"+J}tӟ??;622R }:ƢYYY*J,aA"k׮Rhll!!!3gliixw;hiiR4)))66.E\DDĘ1ceG%cGGN?CFĢ'&, }7 ''gǎP\\|) RbQzitJ=zԻ/8 y>hZL4n$I.zIS&sss]DD1_,1jHJIIֱ)66$K⮜Jڸq#ЀK,,, 5jlP˱U;w._PTx5YtB6mVNHFZMM͂ Fchh2p$={>@2ottjdQԯ[;;;`ɒ%XL 628>_[[tRd!ʾZM6uVbb޼yCLZΝ;@*RTqa+h"^]]]AAC疙8xq'L/doN<6Lұ@ @N'\|'222--秧xT\1w۽{7-((@RSggIX'kkksrrpRX__O5ؚ.PѳX,7oW_=V4պ}c"9ȑ#X-KyyvddEvuu!sÆ X{KJJsaaaR w}1ǎsX?onn1POO;+**V+UL}4c?#j>sjԼh8x/\.?ݻhf׮]t](bx(k$04dh4{`8s f3Iz^R3'СC^^^FGMMM_,>S80PT4 ϟ7mڄ\^^$+gl۷otQQQxh4cQ*f˃aErxђM&Sgg{G'⒀K[ӟvڅ$IΘ1`8 EٌAlܸ:Ƅl~饗>'d2uuu9tK,9rK4lo Aoo/u`¸qWL~ͬ܀ w/uTe7G0__w58wOᲷZ"ɡf`q.x4;UvL,@2NٹUC#Fj'Vvj G~vw]5|-*2wFMc5i% d3HsCP }a'̩.`ݬAaLغLoi;: `hQPٚS:tee L:=`+ϰ5Aݻ~d:p]ܜpYml߾iW\gL4BҸA#.@ Jy@ev٫.F3v$>kZf+4\'TP4$Lpꔽڌal'z۫-ݗQ! `f9Y2l=jC}؋+/Xm"#!b(P|4Ci?Xh:8%Rs(Fq`{LY?̝;wcR~/g9e&LNq̉*sԁ[M)DvvW_}~!A_t_G0!X,'|3D"ѯ.@كV9srr"""e2͛JKK'N%J222R\.={… ]6qD__߰0Lvӧ_x133G5&)33333SPL0aժU---+ǫ?~5k_n4m& .\(\nll죏>zu^OΜ9$11QT$9uԐܹs+V0aBQQQppƍu:L&{Γ)===oNDssߟ{ڵYfd̎G}4 vܹsϙ3g|޽{ZL&[pT*{RSS ͛Bacc<]TT$ wddd>>(H,..>qڋ 吐V+8<F{5 Aټ|6oo/_j|>?** 3z/ANdMMMx0?//OVd%$$<7CCC~i`ٗ/_FF$! m@ww7Ex"n-:tRRRgd2Yll,zLIIX,|>?''_~%0ex"3sN:uϞ=\.7$$5~ivvvNN΁(5888;;gԨQaaasaZ|}RݻQ퐐I&=ӘX9o=c HtwPF ?sWX:.>>3722Ndjj*Zҡ]B_f !YKKΝ;O8%1b(755!bŘU 7 Pj*W3MojE ONNR.\kY &ٳg)#6~xe@G d&L@BڤI`R\\;`:,XΝ;4FZrJHLL,\5:t߿I)l6vh&cymjj@?ᅡ$iӦQ&ѴZmtttBBH$Zp!=\.X,l  o&5jT@@ڞ ^dfx TfX,զCȿQ8jHҒo#3>>~ڵ /'4iݩS(B`0`sZ*AAAFخ_TVV`GBkBRQQH<<<ƌ#H0AAAHEEE%''cتU ׷nݺG}T#h4u[gAV=u~~~VU|&LlZӦM2e ގJ$(MZmaoo7 c=\.>$//;@\.O&WTT`ե}}}6l{ߎ6lzE E._|bXxh 6{s?~|GG(v QTo۶ noooqqqTT LMMNDh7ʕ+_www]]|Hջv튎޹s'&=*HN:}v4ݍI$˫Wl[TTW^^T*)]z56%j`A|Mp|9s&Lu-[`:@# @U!G]8?H76iۉv*4Fgoi8˰9h onD sIR?۹s*/0ծD)Bt;Qpnp-NAϵȥ $AOǐh~==^:}b]t3foqc{='LbȲ4̠Wͬ#E nRj&{ R,EF`U;t:gh/8L3`^&,6@w`8Ֆ*\:; (pHԴzv@lM<[2B#C@Y R *COйx= N7MD$'=RlfG)%'N('I(-23'KJ\4؜_%;9hV Szd%pd8f?# L{tt ncC|})Z_f]agaӨqr2aUe&Κhync/5AEsIyC^ՔtL\4P:L40̹H|@}QdD&$sA٦w .\s5A! OTN :WfP +ȵ_TakBp8rw'uP(DCƍ{7ϟꫯΞ=ᄋ~-PlիW]v._oOLLJs^pt hƍw}7zGsիW?C駟{cr]w۷O ݻwu޽R;pԪUp&N0.wGut ?1["_ܹ7]pgnnYV\\?oFJJJff /Īu֭]&O׿ !9`ӦM󋈈x'njf7mڄ.c$,]taaayyyȸ4i<͛鐚;P$0/ Yy=A̜9/eX6m+pv޼yS"4~T{۶myyyw}w||wމA'&&N<$v~z n ފ+rssd/#WW^40arU\ݻ./0 Y,7-,,ϾuQ4EwС߸]M=effxLL/{󱱱&LZ2f{xxL2JOOwPH((((--RRR;|OzHtʕo Ǐ5<((gAĉk7orgW^^V+^o߾>w /pJ뛔$%ɸq0?>CZ'Mpr9F|сtQFq8'>3ׯ_JϟxX8?2&M&̙3;::bU?ه$F#G(۟B+2w,X>Că>x>G*#cҥ̗.%n>xb :%% ~w(d^^oߎa -jooryH|{{{9Ε+W( 4\@{{Ohܹs/BHHJr]]] hD:`TSSѣG;\]UUۋ7zxxh4qơ7.cl6755QrJz Ez3++ ^^^X I!Tݻws\^. bl&{zz֬Yf6\.ϏEMMMqqqب:uJP z"2a,^f ɘ1c b\`V"S16mĒZ^RR {I:utttbPX,jMlŊXѺ]kkkuu5ju 8~8<iiiR,5ј{;/L?7~XL\xM꧞z*))IѴ"1O@OO\7[VVF)F,???XFf۷yPhY(zyyD˖-CV^+==fz*cjȮcǎ9p"_>~xd0Yl6 b```II ŲZ/rKK }嗑@P(p_ǧ*88m'$$L0ۛ=(Pa]R)t: ovV7Ĵ믱qY Kee%p %>V'N𺺺> Jeaa!htܸqǏGW_}u())`Z).rƍ8F4F`ȼ*V!" jN2mgfVKCCCWW뮻JJJ{zz= v֣RܷW*HJJ1J*//V ))))HkmmF <xٳgy؝;wb3YQQuV̳'NzT3p BY[[e,Tm0]]]xEPT`\j#g$͌澺tuuHȉI6yأW^U~kٹsg[[=SSSi&Tքm6tlwKQWTγk׮;ѣUUU<00zݻscǎ]uUt*J\.ްaCCCC(?W\G}_ݴiөS֬Y|ett߿ptvv^wnooO?Oѩk֭ٴiӗ~\L644\Z׮]d|h4C K/"]pUUUﯩinn袋뮦&azX,Dy{U^xsT(JzQ)'*BOL&|PGdgAU6>*]EEr$^'H$r|_jK.744TUU` TrONNjfDW\*dM&/KTQvԩ|׻n:ac"4x`0(/4 <36mj]t "+**t::_F/!hBrhnn~ꩧ@xpOd,3 wvA 7܀K~_TWWkW^y8777>>j-Kcc`P*F5N;H噙't900PVV+@*'GQ?er 㩧B5o^ 6<DE56mÆ *jO>믿NjPÇ755=3Ha1q*Po@4===|݋\&#{zz] o۶mΝPWW*. D^ ȼ (N 7܀۠QN< Q!{E&m۶[UUUp ҂2~TnݺX,/袑`08<<}v0G?B]o_χJx^/:CQ<!T@ *ٞ\B0ɓ'կnذ@ Rݻw$y>R~sC>w}7* r\n}Cʢ].R RD.Z}~z:B4ݻ#JFTU磷 >DyyyEET788J@rV; L&Tʉh3ͳ5 8>,+8q\q5yt:3 nooG5|Ynk4fff6l؀eo~QCKbg,SO󦧧q~3yxv#_p|O?T~aZ媭EV>44TZZ*=c.kʕ5s8(J?W jJbY[dJ.C4Qߠo+.4iFuǏGoE{ ir?'$b̈Zr9uppP(oף~Lvq^Cb`G~ӟ"1==Dj_,‚ZFgr|$Jp&&&JKKq ; ?Uz{Ж;w*t:*" ;tzǎ(۲e˖-[dz衇Pyaa!ٳ\.xvB!xN8QXXH$:Frᶶ6t,v---h4<2Ӿ>effٳ(LOO2SN ok1χRT`;>>/~5;v -E russs=J)gggQ믿3TN)***B a) u],˺\|phh( F͆,?P%z?oH$8333@ ߏNx< FD&UWW{}}}333v766v 7~ai'N@uuuwq_?tP"8r}D,~LO]rh'-W SOK 7mrsܴAhRQޚo2B8_tM {,lxKrq$ܵ乓>˿7f.:&w AI.~;p2CA\ `+9 9CNpK.0D}n@ﯽfU0o}vy:!2T*;+n~.YpK [zfLt: x_Wg+e}[R5k!RP#zZ_`EܷM\F6u:/]ҒH~\U>7P,^wu\ <`EyR-Y0*T`4f. y"BqFJaÆ@~g~@qݺu@ꫯh4;v옙I$7|ݻ;VSSo~gaa[ݻ[[[ovi=NW^y%}oZ֞ok=vn߾};j߾}#GTUUo}Y,~:ٳk۶mVfYf\sp {:;;կ"#t{/:~pGy$OMM=CO޵kח;%'''ۇ>99b[ne0X~[[[.ONNn߾}ppK.]^^nܸqbbvﯬڴiӆ L&*..>u,,,|###**bO8Wj*TD0L]]̌㣡P_2ԷmHH@*FF3g\wuHmr.rT>zFٷoԺС{^z)2xWWv/<22jQ*hm۶3cDf۷oؘF)))!1KKK)B'V8FObkсG(mѤt 8Os 7SžohH$(,--STyyy4EOR{/(kJ¿G}^^ed8|ԷonkkdHtVB4lܸƖ첂ꪫv! ST"H{)۶mғkyTGa@6Dz,ұCG@AA:/ ) w|N''FV+>GvsQ䷦> OO:>t:QȲ:>n>33|S[[t:Q[mh4kcbohhC5rΞ=k64>s VdF.P+`? B/dIH$L`===gxx088.(P(*VT>w̙BގJc_wZfgg{ ^7T!^|Eğ_fBS:44$.E055u1>?ӆa|Doo/c\[]]F_>zߎ츥D} 4٦QK^o DŅhy_~y4M;AeȩT jպ~/UbǏz`0 QMۿb)~ll+H$ۇGW^y%9r[o=z`ooo[[b;>>^WWgwYB'ONN:u qGپ}{ii)I ;;;~>( s=W>Jk,vZ9JuN>Jc)殮.j׾5:;;?#_nd߿PywߍAc^z)Ll6,z Df&GUdr($ /| t6ryyؐ# 4:Oow , r^|+9 x):9r83+~IfۿVQxq} 2GK@4 eSx'Z^@g;3x+es"\|I `;6ɚJa!"@/Di>o|O\C.w;ϴ+}x?m:/w[s0xs ,2;idVZZH4NRDgⳎSNqlkn7zGVf-ğ Wը%U'у wF#LbMM =5lٌ!}ZPtMi@]n[nԩSÉDbttK_UW]uȑtoÑHz/PCCBUVdb}w'|RӵtM&K/VF7|noogY+_ g?k06o|755,o|#??[nAG2ڵ vWXj>#---v{/{4իٳrʾnmaaaz//**zO={NgSSӍ7t:c~C1 }Y.oݺ=~n{W|N駟ve]6446}>ٵkg>?ͩ|7F㝴k?GugffZZZ<Oeet~~;sW⺁?8e-|o`hhhxgx< / 1\^FڊJZmMMϜ9꫸w֖_ T*tҒh|!Z**jRh88tP<WՇF$_yaPAyy9zVR<CygPUoF{{{m6ڵkg?~P[[KӴU(:raPM/Ç~x4M4}7c{\ZZN=y^Tѳ^{ !?c_nƿD[ɁIZ{7d2fD^/:_t:Qt$L]vMOOCğ~ip%%%HgƫWv|̙36)bJOP=\._r]X}g_xݻw>~t#Ԡ,ԥR+ /Qaɓ'Q[oUSSMȾ뮻Ua~H$RRRt:}>oqm]V&ڐ{6tz\.袋6np8PIF~~ʕ * l @)?ّ|g@PʉF:667EQ>-xv;:onnwEVT*Ee~矯kooKP &_UuvvbX,O>>F+hM$ N3"@ӡF)BZ,TTVVvQT՘bd2Y__  i!Gn>Bd2x fffE,F"Q$M%%%Ȏ_|ETVM&S8h4((iQh4>FEh{9֫x饗998'6~ltt4iT N<933 GFFq8W_}3gdccBE5h4J 걱1͆AB (JYE1L~G[n###x6qT0L8FԷ brDmyy9Ze]vȑH$vړ'Oz^XPPO&(RUUUQMyM.bэ7 twwRWLMӛ7oFg>W_}OLOWWwL$ MLLx.@7770˲k֬yw/h4Gbl6o޼v=33ʖRK~%x/M>EP*:XE  S/^4˲4:7r&.|\roVbX{{dx|nnh45vSS_Ds͚5dg?W\YPP֦jwaP+"^DQ_z˖-6Kܹ|q{nOd"7oVAAAkkPGG{82?O\.]PP {zz}pZ /ӧyd2iZ۷lDv{OOGhO֮]{ȑ/iRZZ:<bYvϞ=6nl6VPPt:vFb89j:?!+aXÿ-0g??={0 6:.NnFDBPRt:MӴBH$9kzsSH$rPewMhXeDY62FF@@k4sGs\bXM̋=)_Ot=Rd,V%NVFLeVJ:r d `\̲XsSY.[5Ԟ+inRC]qK:l0ih4@.2AI IJW"W\[L$YV/&@.g"I:=1RÑd-敗_DޮR ^oB[lS]E'gF>Zu_6l2)CgCl45b>5vr?D"Tl͚r¤ӹj|d*{?/UslT2-*@62 PN $~6apݛgFvev?>ݶmMSSDbfarr6? E+VE?<{Ϝ߸6wu:ǽvY.+,kBiݹsLqcxx)(CnwN\Y\UFhje,(ehlb+X}S;vGrd257H>_phhjݺj\?cD"6x8vmcW^wah4ժ}izHEEp:;HGPMMؘhYF/i,tmmi[M )^jH n( -M'"DGYa|.("/H~-N%"ٳ+O cPXojR.kkK m]]y2N&S5k*ZFe&ȾbE!㑑i3 cff|=:55722rY =00kjJgL&ڵf j5,''iFQzl jU}}--}SS078ten.G;:ؘgrrچ<?0--}}Nө}PIo-j655zNB--} F`hhbl3>>x{@duwMMDjzz~ppرD"'N BT:Ot:m(5yyD"vU*E,裶em6s*j'ʢIat:5ֶ䝂,`'Uvf(EP%GxO@fMQˢ?asDͤY63{(6HٕE/LGq^Nj hԳ,g#6\VPVzaXݬPzfbrY[Z m6֭ x"RB^P?6橪r+rR188i6nA%H*әP6ժ5ZriF. ::]QT*ss[R3QbvKoeM$Jbttj5npxg]]Z(`\x<&K*x|kTl6f(\g7m NLlk%(c q/m[1D "DDgRXa",gCRpbd0m6*hLDΕ{0E}gXڤTPcPa< ىOc :fQ+p_RX E :h H5 DFFHF$_#HoJrMe|Ed[oNx"f5nu:5˲DJUKd"FFE)t xq5ŅIy;X"L1bGoq)8( L(1yJLh3R";D~ 7-)qRd2R)40ۇQN%& }^i:Y,^MӉق|RJ(<b`Y6b4av Eu: ls$UB/IΖx{+ZYb2FtX ,'M0ٸ;JE0avpp2vv_|qɓ]_a^D'EA^c>d.bd$ yQ%{&E SK&tw -ʌ%W,aIxJyցqoq4LN:y.UQUWޱ"N?|̎?l$ɨtY;bE\ 7R5!?l X5ZG:glj\f^)//p: \"`[8nHdϲ,08T*61f~vHKSW”) .L'S$=ˑE3ElX( \xaɓϫXVC}}mmP#X$K&S07JZFh"Oд\RXQ899~}Z#QdŠccD"t LNO#ckgĉQ/EA,p35 E}ĄWFc_J,n˜j( Tb)G:BYe*W?1!<3BkTjPӡ|QK=8a]UV ҋK&ʬ8E0@ܘKtOBtA%BF.HVEA0U*iTh\UɑRVZh\VXQDQ7o^TZ״ ^] D,tTTdSPUUVȴiDbZztt FrYQXV-GwB vD2NYa\b@ڃLR3b̞И1 YY lW8(NYȔq!2EW$CpH8Pq h2B,T@j<.2-AѸDzё#F D2aRJ4ꋦM ng)哙r2!hɒxEQ%H|-BaV"5ԑc Y1ZDFrQ8 gqĊen4D L.ڰcl9)R隗*,р"c!g>,K j"1Rwb8^D@2k [#l6inijŒ4sdbY[H&^o LdO 3K;#ږa12%BE9%˘0 Abc9y1BN+d\NK\] Y0* В `nJ;GqeU @LHtlBXd$deH$'} z]D5.; }qH"娥D6@ 8l:0 7;x|>|d{Ê9g iM,4|Gdjf38+ټȵA !> f$&%fV$)$l&dA 6^?+Bn%R^:dki1yu7?MMͅBѦ.QCJ)M)p9%*X86HX6vb0hW((Z8y 'Yk YU (-?JЏ7QApDɐ Z-qFDdb8 '`dJNDJF(B9%N EA p.IJ1(f($[8))1(Iџ+W|>shapP__ڵD1x'S(2:# llfcw"P*+DE,q0gYb0l[aFY?韈·rxF"0†4A{ JB(`Dueibӑ4c9" eU*)Yl`jJrl@ΞL |B!7"KiYdZ +,qڵ2kj*M\Q"с_$f&ȶD}IU we2:vb1!VNcd]]ٳݣ謟h4QV B F*+oIeU*Gv822аBT!WRK2>ŲT"8٢"R`J`ˉX XfX" !hUYRW{ نU:dqd9!P(bEN9u[ՕyJJJJT* <S4qr,͂!땬F(X T,b%?[(Gv!v=mmK.Y?βloX".ɹ@ \QQxxGaEwAEϧXpp;==_QQJu:M"e3L"NcY' \"jGpHR@ ӒlQG6y]L. %a$a٭h,ڬY2 gGE 1q"gpJ2LR3Z+ep.m dC %Б]%HHKt: g3JRIC6fظk`܃3|$Tn †%{$̿mX%҉$c))C)0ry›H ؖ &3 CDo,"'zơhJ5r~L|- K)w`8rN Ap33H3M` fi6Ͱ2e J){[40QҲ4kG!f$' Y|΀h˟r:Y&PMzMl/ d6Uhبݬ\_cn:`BTQ0l0ᔆS&^j5*KO_'򌊂|5pyլjPT"ԔꔴnQ@8e7+IO{bըuez6몍nI{$LQe _kL, rYBBR VCY-fց,<&¦GI'0QD@t΂y! D_^R=f,3bߒXp'&ƀޅ:&ڈ`sIbXK u;4`.DT2c2$9i<,3ZI .}",G"$hJUMٿ7Pva!8D"Ms-@:]Mٙ8w$XTtRvyIYZ2ADͨjM]gr\.Gjs5k*U*:FGgjkKGvRX *ްﴊ99 \H$k&R)nX B OrȄr:iWCB^_hdœ+2QiĢ8^e)UI-l1s$^D)%fȿH %#ѸGJĬ.v@҅%1sYRzY\@%}8T*V,QV(^3?PQQX]jMM`0RUV2YD#./7k %/L奕=.wJݲˀgsYbaTYsOY-ܱ,rc,%=4F,o# n-6ɒ,DӬPgFK!Q#e;$~ ۇ[ s]pOb[jj[.kFz iլl+L[6d)3#6vb,E K$ikٷd d)V H$)'8<Ą6LļrRpYH8 p$PBuS$Nq#\4 mlQB.ChnU'i9vpHYl٦hCН؃e|a+,MIcDU@ҾҎ%âbiwG.*:u/ٗ:V6 Q-F~ א %lR7;6QIΎ";i<%=KwCAl"_@e5].x(Jm}DԜeE#ee&qGrDwM~ވp$+.l^J4S>d)|S%y;IJ𮚈Y22 }$ёL P+ AHQAtOrKE0ɋA #!bD/EQT=$bayJt EA{Pq6a\Ŏx<ɲlq鴾^uUpLOP(j*Y,^[\y5ZS ,tl7Ь<م$74;5sD݌Kd='$s2 ) @lya+"sXb͉:~nӕt=Bb;,5E$ 1 Mr>nDΈOֿf>a)grΐy9Vt eU`dժ9һ\VbnBo\D"YZ+zzsodRmvm\R$Ԍbch%cpkw+sbRI\Y`^V2\Xձ\]((,X>ꂉ(J(L$^S@,֘fa0jHpvrӕ=#$8DŽ枙?-~\7 2jHq jkKgg]v\.[ *+݉Dh!pX\.kIJ'Q(4iA@Og%1Bd,"dH.Y~ٕ 2 "UiCTW2, "DH(H Oq\ 7NQ,҅>4g>)CVhLZ*BTäRjHE.X N0OAk0hџ Z@dn4#"ix~I I`B|HP4(d@QROh a H$* ېP|h`y3HK&Hx`5s P%'b -|nI"w$/,zᖄa P ,X& $Y>x2F2'?$7m3S⍄߬'gn5ىaq@C[e5#HmqYL06AOjN⤊MY?B#ظHG4(&ckf&.XAU`\'XWH-qMJOBI-3]hOip,A C*JJ!Ѥan a";E0S/R* XH *dT0tʪ ptLD n ,42$QH68⤂OH c A#eLFpȲt$ !cAF<#|+).HOx% clh:Ƌl@ԥ*bѨK&S.wb1< @mXJFm,iдq#S!Kمcy gD!#p0,UY\J9W"SH@(r[(I4Pa #%ad\{IA{ p4>_ #8;1OB8, TD^@Hd#`#d&|̧jh4qcUmmؘ9y EO*+sUVݶ'::{{M&/\S! !W *= 'z{;fDf0U$#x XK\}-w=/מZd֢8Dx5bpN" 1<翹Ԏ"uBpb̂IΩBI), *ˬf1"0K6 .ǝ6s۶5FfX,QYY$7k#C'rj/VUwzLmmS.YiL?e^GG=3ӵtw,E }ǏI>t,-h>Fv/B!P'V a'>pAE71-,,ƲE7Bq+]/2 K>G7 t: !qsEÂ<%J9X#%mժ{Q!'0`j+?FVl<P&sLk\U״00;/׮S { ٹqc!4đ"@m'huS)jBv<8:v ᗅMt_wxI6ޥ UrrUW)pKLKɴږ^R7|½p iwQ񤟘8D Q:(FTH<)$H;<Zs9c:1Q0za$/8 gyh.Q%M" oy/SG9O_K/mqX?NqڿKPA CYh0PLSrI9H@f@o_Ysr'M[la}3$µh:,MDd ]mћo^~xiY_)s]8$Sy& Q{ %J#MEQ~@$-BI:˗Dv!2)^"Ε$:(ZC'u>n.vi WH2yJu_7 >h/]S޽gp[+eM&ottE eWUARy8vUYlɔClC;=C,c||I紮J`*[1H ?ImJE"zB(+ݰ=X04D!p nU [yD 7c!t6е(IZoj+" w͛˘$zk9OM1r0 P vZrhT$\-kH[e҆{?x`s7J'&@u&ZEQ|0#h0DZE dO'5n(lp5Q<0 H ɴ"-CP&uIgHD!`׮]$ȒM*-1xPBR@'kM9O6ckO q>qh,3(: Dtա0QWqC0:HW"%L1T;r@ 'Y(P|r.ҹH]S, kPfZ Tj4SwF 4>,@6@=Z%{{#u8QvkϪQ4rXS2 &Qj ,Ò2(3ҎQj22i-3ʠ.bPLD: UZdM&IV]Ymq\v8]-n4U^(xU F&!.&fR%EMp;y_\UIZPms{V~'(܆" ؊ ,tU&j TM8\YJ_K~f%!m!Sa1Q{ͤzpMQ¸z-(14)ʹP(iPкM7 Չ ;wVq>i4ڳcwǛ|& w:H$cDPΎ kŕxPj*;sI3H6Zxʤp54kz0pg9D a+(LeQ) H.Haj JUtvIm@~ 52$KA!Dŋ};Wwv'+PnWIc;bbYUNJ93ݩ҃ssնj;?-끌pΉ84d92D4n1D = !ж.5sPb/j8a D\DTwc8J 3a&C]!Tv14V6.M^vqmm?1X\i6;mӣN\aeL&?6_$19f.ь#+Ie8k;puFyb&qJt:"O[ KVT)Dk"XLJ""JѭpD^³qJGtr%3J+SDPq*~@dL7rɧr9zko)R8RG90!y.P46SV:ctFD& (0  c>hؙ(&m>p-*+ʲPT)L)4 @"m3)j/]d!vJIBH/4B ĤB wTh[j^hQK JLIR*G+HLmۉZ|鐦+$JLӡbJa9yB K"5׸c CT TXAY\ ŗ=ͩa!W?' [xL%7Af 扺׈.zB#C}v8;ZAp˶hv,`\J6ru"1+#-ҹtvsHnGSͳ?t^Y!nd<r)܀tzٱ'O6GF/v:P(ϧwvNjF;ܹW*FŝR$n4ڌV79Y=ǣTb076_}I}li4tr0"p,M$bjOZa\` v >)+&ok4>eUߙ0B #h~lQ3 sJW2jKm=fQ۞VqE0jCf\REeQz4FŨ(}*Hi6^$_sZm&^ov7+Blrm6Vwo/ן͛WQ4T/N۽|>=إRxwdXݻ~~w+ϼD"& " mB5Ԣ4Z Oޭ;z֫WgLYzYX@pG%Ǫ*>Q>)a qFpB (|XʒPxƹ0hjtt-Ʉ8|zo$LN U''KNqq[SSx<:77\8.MG|>=;;N> C/{TGGG]Z۝N_<[,}@5gAM/ 8_^oxDžF9p z}!{W$2M$WM(^"FMD5g l*Ih>vWz+}y)}~0A߅8o^1,QXsX}iyeϳ9vR2~Ť$J*˴bxĽHGl pQ@߲!]S1\T>5|{jhBE@7)0S4%Yil) p"M"MR% N kJ\mQ Wq?*$C`q*`o*f M !U^ry6TJ0ksӐ*Jk7PH(RikČGiK[  tGGi +#2*UYm~yEX"7N<Ѥ lxM&H g7үZBv\1$޵"?y p8mqa>p5?L~npž+Aj~h*éBZ7\+ˆ޿0M#M#/:QY[۽~}B|n6L1*W݁yB6@?>}O}ENOz9<˥XڬZT"NضN'jׯ_ǣ[OrLҲ۷W]g?w2e9Rŋÿ8VT*^;;;x1 孭-uĕ+W=[ȍoMODfʺI <  *Wͬ{D*@JA(Q9A+y?䐤p*ݐ91F |`W 4 N]㱱Z*J^{8jukTޞq.]GLUsk߼FnZtz :~==qc>D,.N͓T*0sN'AgMMWWw}{._ZBD2<>yt:J%N[U.OOOvo4|qp()TCST-G`&'>( x&MʒRs'8}&]c2t)pEP-Jx CeU7 3, +h4˲{A:l6B92 Xg8dGGm CpضX,RD3ضϧ;8xgYN2t{A^y-T4 BfXzh4lvsT8N'tm=_nH$i>rVkjj… a=w>GQMwlOsQ,z3cps'y؀%TZ77BBW(SMc a-M"~V7ڜx$Tj Lh_"U>,NQh5gIR~|Cr@Kx9 `&cbZuF?>E(uup :L5awIۮr@,klNU@>Yspш lk!gM{L4"ً ,ñkp GܲPEnwLƅSq&gLmWJ`Z:|8 6tz7>:WSm48`~˜g'bjӥFM`tBbGYk YM{ҥT橛b#EWV)?VeRڑ ig hhM]41%'Fg4sNڣG?}l{rt|\zu͹񭭣L&g{fftk0K9777V*VǑV*u_w?ޜ9>(UL&H X0r\=nDEɉ%`~@oRX8hkca6U( fwj2/<&@f6Y*Yn;k: ܼk*@6ڼLQcfx 6K)5*G g 3?EӉ_fS4>km;_}8bJ|lv{cP466OOǮmqgfF-O?W(dVV^$1r:t*%uyȌ)߯rZ )ܔMJa(~ G) @  Q4ph)PH [0it R+=BY%81(Z4VThU'xZ!87@yqT>q~+Մ4T+^gd%=`b ĵM'莊ƆrbWw~7[\Siɳ`O&\o‚1hi7-0i!*\Q8Q wa^ TOUM#\Ma?($_n{́ʭ@2m)"EP'GZ>Qo-Ɛńp9A!bhlpbZj`x, u&x+ Tto ߹* t#T]PaVcy) z4)D&Fq0j=yZ$f?=mc'cfgt4w23S#&KT$/?yҒD#q휘 .VՑZt{y< v,_v϶݉LF~ Teҥ)20ӁayF]@n4_}zPPQK疳) (B&6Uc/9*WaFcqv+Z$3J\ZA-B>4r!:SΦpHOMiXgoCM*%' ' @X'-r86o{{bj]NW! +4(5bO4`})U1şGȀeCOae-j)YpN(h$NSPo䆛: b⮨ 5Ղ<*[elq!ܦ^u/!gCPhi"D auH~xF⌚z ?VQi( xH_ZZ&ScI2:P,H{YF:D1ZZ5ӰP*.mY6c, XR/`N,%۹A̝w.' hYhDCĹi`\(&ݛ'\ "uN1Xsi-MJJ PL*18W;5@82J'eT-RPH tV24 05 JJAG!N'_y{Z<55U>88 ~z7wwOgX̦S޻Ç/"U*rj\.93vEN:Bͬr3;m?Ȁ:V#@~ @ G[*9vcW|]"tn4QȰDY_EJ*MA$> bw0hALÐU"#'4ىw1L晊*pmN||P(d76/<{83s]n6ܽ{oaݻ&?NNNNNNFbxh46֡hDdSeDUb]r,H s9J6 Wʿd"Ț1uAk}fВ˨ )cISE,M"a>U"L=Ie:4M<4;::^og;;J<[^(ݼyeb˥\ tWVNNo|t:…hw|z@u76R/#\~KtVtvJ "ONcMڟH8g*LՕ 3j=QJ±~ p_G_;f#F5 (IbXNLo/%?Xl}}嗿g>=F#NFGG-ˎD"猁)5VQc˰?{ dT$SJG^: b"&3tt) 0PP@t Shvm 2Ut>PEra)K)*FG`0L<1]ALSjA!8̻p{-M sz,ky9H8|OB 8 $S{&YNsK?HX0|t˳$59GZ6ȈЂQ2P/wHjr(A69[VW(!wxL E t>Dk729"duDD4Y<p`@StnGB= ;}DZTOM6#0وkr" jMTۂ%q(]\EJzmYAێA H=%-"l GZp: Ӊɤ $$q2$K4B)j`uqz).2E~3tDBP/SFJ"CӫRDå,5 ÁS`K ЏBlo'+rko/N;_HUav$Ÿ=ˌض vFFV+rx/j5:>>x"U.j$>1?:ONON##vż *E"?1?ČKo1#V֤'!49C$E z ReB' P(VlIy`Lqhs|XxU4CץW\yz k+SII4MWԎT?Q*Yi''&{{I jmJ% ͈e/RA>=g*N'l}=}xIJmo-X{t3F W[@Kbwc5fbz`º9X)G//*o W` )z A&OoYDS.b>B45@jkzB_ Oc(Qb\4Xc݆&GM('BpFsk+5;ۭբ=c`,r(c<"^*Y|f559Qo~SOf.\nnx^ŦɤNf3:?߉|c~>"436Tm*MN n1̔=@+I(ylh AAA՘8 oU\;9/,Lݹ׶_b_X<ss E^op hrp=C"v''=ؤLYHqE9G}.1dJ׉i郲DlsD&mgk^oZ55UNhcpw=~92i{~+nyXm۝GHdj[ zK$bKK3H8j7X-Z]_/N f7,޽gϞ펏, ,Bqoz233= n:>c,N,-̈́B,4ݷ߾rx<ҥwwN<ѓG~Dśv0ƺA.99N&{ͦ.\/ض/$^(dv*X,L-۽x<F,ˉFÍFgttu=u?p XގF#D~df2~j6;BVkZ˥^>al_e7d2E;۽r98n$Fшyj\Οzu8?? 麞e9DQ߷RX, mvW,f==XfFPV6Mϧ[reyd왌|c_465t0axh.H{i4rH!HVA{䙞c)P ^TD4@2"^N7t牗rΡ^o hfN/=qp8YffF}@?!eG"P(亞8xrqqvι_}+2ZI?gB!Ol{ͣdIIӏŢH^sx9bZoo/z0Ҙ!bPQhW+92R%(L- W8˜;T 1"Yp. 1L>_ 669/Yd++/8'O._{lvͮeٿ~:dToX֮T/-.գG;;寿~lv'&Jp3w>D{|֭Ӎ\.J?̓'[GGJ>>^|(|f9_]On?~E^ŗ𰺻{8/qŋ#v>Ε+sU;amg猱ёzlvlۭTJscc? }b1s^#*~rPŘze1NS T:W |bE8\B*()Lsv&mؠvdP^H6A*^ZY\{㎎tёL&šO3NrVR)ϧggDztyuu\οҟLr9_*_Ӄӹ|>mYN:}{חYzKo>|_fSJivv^[l4ڽ瓓 d2)y6d,T\5yZw޹.,ZܯNOmTw_nbA5p]:wtT eį)cͫByq6X_ CW\lv:t#B C8䖮ݵJY Y|jA̲d^S.RQI)0c;l4ԃ" H]50%8\>2Lg( ^ :<9 -rX,yj3bRnbnfffƎjEzunttSĥK8[ˍFVkEV{啅B!;::ϧwZ.soq1ăKK3ׯϻG;T;Ţt:Ǯ^Ӯ띜 ,M3KSޠo]yK0\cP(d\[\SgfƮ^;<N(mrO>W(d+ϟ7\.Dݧ|zex1h6}xXvODioy8صZ˶Z'w]hgO=mwd$ɖe9f߷Z^3oy}T4VWovgvSD*ʕ 죏Y^ ?ݻϲٔf/o^i4:kbd2Z``x䤱snwv*<(luuX_[Y`_8gmh%ݗ ,ӪxG40%!R2MF\8%ƧtS#SK(1F\P~)8KG,A=Q[ y KMNӧ;##vW''KljRi|\.+LOzg`vv~zib Lʿ Fx4~튿/=(\.88ss''^oN'DZmygrǣT|eE.N&cǟ=i.Ǐ7~+++/O~rgt޻v*췿r͛WV6\NJ 7n\Ō _ (Cs4]1.dw t}1C%L 7$^"Hn j{,M&t&?&ogIMdn`6c_ Q5gWO֧qT ejs9:V`ԁ!@ :>^X+p giRL\. '867Ÿ?>^vϿ4 endstream endobj 180 0 obj << /Type /Page /Parent 3 0 R /Annots [ 182 0 R 186 0 R 188 0 R 190 0 R 192 0 R 194 0 R 196 0 R 198 0 R 200 0 R 204 0 R 206 0 R 208 0 R 210 0 R 212 0 R 214 0 R 216 0 R 218 0 R 222 0 R 224 0 R 226 0 R 228 0 R 230 0 R 232 0 R 234 0 R ] /Contents 181 0 R >> endobj 181 0 obj << /Length 13764 >> stream 0.271 0.267 0.267 rg q 15.000 40.420 577.500 736.580 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(encountered in 2009. Note that in this case, the zanamivir resistance information is contained in a linked reference, not in the )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(GenBank record itself. Although we can track any positions character value with SeqMonitor, the metadata are not complete if )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(the parser cannot find the appropriate tags. Manual curation is necessary to keep the system accurate.)] TJ ET 0.965 0.965 0.965 rg 26.250 428.908 555.000 304.877 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 733.786 m 581.250 733.786 l 581.250 733.036 l 26.250 733.036 l f 26.250 428.908 m 581.250 428.908 l 581.250 429.658 l 26.250 429.658 l f q 201.750 0 0 225.000 35.250 499.036 cm /I20 Do Q q 35.250 440.158 537.000 52.877 re W n 0.271 0.267 0.267 rg BT 35.250 483.512 Td /F4 9.8 Tf [(Fig. 3: Temporal and geographic distribution of NA K136, a mutation linked to zanamivir resistance.)] TJ ET BT 35.250 464.142 Td /F1 9.8 Tf [(This mutation has been seen mainly in the southern hemisphere and tropical regions. Interestingly, it has not been found )] TJ ET BT 35.250 450.406 Td /F1 9.8 Tf [(yet in the most thoroughly sampled country, the USA, even though it could be found as early as 2006.)] TJ ET Q BT 26.250 394.687 Td /F4 12.0 Tf [(Conclusion)] TJ ET BT 26.250 374.733 Td /F1 9.8 Tf [(The primary motivations for SeqMonitor are to facilitate the identification of characteristic mutations for a given sequence set )] TJ ET BT 26.250 362.828 Td /F1 9.8 Tf [(and to detect new sequence variants as they emerge in the public databases. SeqMonitor can allow the exploitation of a )] TJ ET BT 26.250 350.923 Td /F1 9.8 Tf [(growing body of general and strain-specific knowledge about the influenza A virus, as new site information can be added to the )] TJ ET BT 26.250 339.018 Td /F1 9.8 Tf [(system as results are described in the literature )] TJ ET 0.267 0.267 0.267 rg BT 233.243 339.018 Td /F1 9.8 Tf [([4])] TJ ET BT 244.085 339.018 Td /F1 9.8 Tf [([5])] TJ ET BT 254.927 339.018 Td /F1 9.8 Tf [([13])] TJ ET BT 271.190 339.018 Td /F1 9.8 Tf [([14])] TJ ET BT 287.453 339.018 Td /F1 9.8 Tf [([15])] TJ ET BT 303.716 339.018 Td /F1 9.8 Tf [([16])] TJ ET BT 319.978 339.018 Td /F1 9.8 Tf [([17])] TJ ET 0.271 0.267 0.267 rg BT 336.241 339.018 Td /F1 9.8 Tf [( . Currently, the SeqMonitor web application and data )] TJ ET BT 26.250 327.114 Td /F1 9.8 Tf [(warehouse supports the H1N1 hemagglutinin and neuraminidase genes, but we will be expanding the system to track other )] TJ ET BT 26.250 315.209 Td /F1 9.8 Tf [(subtypes and genes, which will allow analysis of resistance to antivirals such as the M2-targeting adamantane. The system is )] TJ ET BT 26.250 303.304 Td /F1 9.8 Tf [(sufficiently generic that it can be adapted to any set of homologous sequences for which annotation is available, although the )] TJ ET BT 26.250 291.399 Td /F1 9.8 Tf [(clarity and reliability of the analysis are highest when sequences are very similar and differ by few or no insertion and deletion )] TJ ET BT 26.250 279.495 Td /F1 9.8 Tf [(mutations.)] TJ ET BT 26.250 242.892 Td /F4 12.0 Tf [(Funding Sources)] TJ ET BT 26.250 222.938 Td /F1 9.8 Tf [(Development of SeqMonitor was supported in part by Genome Atlantic. NJM is supported by an NSERC postgraduate )] TJ ET BT 26.250 211.033 Td /F1 9.8 Tf [(scholarship. DHP is supported by the Killam Trusts. RGB acknowledges the support of the Canada Research Chairs program.)] TJ ET BT 26.250 174.431 Td /F4 12.0 Tf [(Competing Interests)] TJ ET BT 26.250 154.476 Td /F1 9.8 Tf [(The authors declare that they have no competing financial interests.)] TJ ET BT 26.250 117.874 Td /F4 12.0 Tf [(References)] TJ ET BT 26.250 90.420 Td /F1 9.8 Tf [(1.)] TJ ET BT 38.132 90.420 Td /F1 9.8 Tf [(Fraser C, Donnelly CA, Cauchemez S, Hanage WP, Van Kerkhove MD, Hollingsworth TD, Griffin J, Baggaley RF, Jenkins )] TJ ET BT 26.250 78.515 Td /F1 9.8 Tf [(HE, Lyons EJ, Jombart T, Hinsley WR, Grassly NC, Balloux F, Ghani AC, Ferguson NM, Rambaut A, Pybus OG, Lopez-Gatell )] TJ ET BT 26.250 66.610 Td /F1 9.8 Tf [(H, Alpuche-Aranda CM, Chapela IB, Zavala EP, Guevara DM, Checchi F, Garcia E, Hugonnet S, Roth C; WHO Rapid )] TJ ET BT 26.250 54.705 Td /F1 9.8 Tf [(Pandemic Assessment Collaboration. Pandemic potential of a strain of influenza A \(H1N1\): early findings. Science. 2009 Jun )] TJ ET Q q 15.000 40.420 577.500 736.580 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(encountered in 2009. Note that in this case, the zanamivir resistance information is contained in a linked reference, not in the )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(GenBank record itself. Although we can track any positions character value with SeqMonitor, the metadata are not complete if )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(the parser cannot find the appropriate tags. Manual curation is necessary to keep the system accurate.)] TJ ET 0.965 0.965 0.965 rg 26.250 428.908 555.000 304.877 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 733.786 m 581.250 733.786 l 581.250 733.036 l 26.250 733.036 l f 26.250 428.908 m 581.250 428.908 l 581.250 429.658 l 26.250 429.658 l f q 201.750 0 0 225.000 35.250 499.036 cm /I22 Do Q q 35.250 440.158 537.000 52.877 re W n 0.271 0.267 0.267 rg BT 35.250 483.512 Td /F4 9.8 Tf [(Fig. 3: Temporal and geographic distribution of NA K136, a mutation linked to zanamivir resistance.)] TJ ET BT 35.250 464.142 Td /F1 9.8 Tf [(This mutation has been seen mainly in the southern hemisphere and tropical regions. Interestingly, it has not been found )] TJ ET BT 35.250 450.406 Td /F1 9.8 Tf [(yet in the most thoroughly sampled country, the USA, even though it could be found as early as 2006.)] TJ ET Q BT 26.250 394.687 Td /F4 12.0 Tf [(Conclusion)] TJ ET BT 26.250 374.733 Td /F1 9.8 Tf [(The primary motivations for SeqMonitor are to facilitate the identification of characteristic mutations for a given sequence set )] TJ ET BT 26.250 362.828 Td /F1 9.8 Tf [(and to detect new sequence variants as they emerge in the public databases. SeqMonitor can allow the exploitation of a )] TJ ET BT 26.250 350.923 Td /F1 9.8 Tf [(growing body of general and strain-specific knowledge about the influenza A virus, as new site information can be added to the )] TJ ET BT 26.250 339.018 Td /F1 9.8 Tf [(system as results are described in the literature )] TJ ET 0.267 0.267 0.267 rg BT 233.243 339.018 Td /F1 9.8 Tf [([4])] TJ ET BT 244.085 339.018 Td /F1 9.8 Tf [([5])] TJ ET BT 254.927 339.018 Td /F1 9.8 Tf [([13])] TJ ET BT 271.190 339.018 Td /F1 9.8 Tf [([14])] TJ ET BT 287.453 339.018 Td /F1 9.8 Tf [([15])] TJ ET BT 303.716 339.018 Td /F1 9.8 Tf [([16])] TJ ET BT 319.978 339.018 Td /F1 9.8 Tf [([17])] TJ ET 0.271 0.267 0.267 rg BT 336.241 339.018 Td /F1 9.8 Tf [( . Currently, the SeqMonitor web application and data )] TJ ET BT 26.250 327.114 Td /F1 9.8 Tf [(warehouse supports the H1N1 hemagglutinin and neuraminidase genes, but we will be expanding the system to track other )] TJ ET BT 26.250 315.209 Td /F1 9.8 Tf [(subtypes and genes, which will allow analysis of resistance to antivirals such as the M2-targeting adamantane. The system is )] TJ ET BT 26.250 303.304 Td /F1 9.8 Tf [(sufficiently generic that it can be adapted to any set of homologous sequences for which annotation is available, although the )] TJ ET BT 26.250 291.399 Td /F1 9.8 Tf [(clarity and reliability of the analysis are highest when sequences are very similar and differ by few or no insertion and deletion )] TJ ET BT 26.250 279.495 Td /F1 9.8 Tf [(mutations.)] TJ ET BT 26.250 242.892 Td /F4 12.0 Tf [(Funding Sources)] TJ ET BT 26.250 222.938 Td /F1 9.8 Tf [(Development of SeqMonitor was supported in part by Genome Atlantic. NJM is supported by an NSERC postgraduate )] TJ ET BT 26.250 211.033 Td /F1 9.8 Tf [(scholarship. DHP is supported by the Killam Trusts. RGB acknowledges the support of the Canada Research Chairs program.)] TJ ET BT 26.250 174.431 Td /F4 12.0 Tf [(Competing Interests)] TJ ET BT 26.250 154.476 Td /F1 9.8 Tf [(The authors declare that they have no competing financial interests.)] TJ ET BT 26.250 117.874 Td /F4 12.0 Tf [(References)] TJ ET BT 26.250 90.420 Td /F1 9.8 Tf [(1.)] TJ ET BT 38.132 90.420 Td /F1 9.8 Tf [(Fraser C, Donnelly CA, Cauchemez S, Hanage WP, Van Kerkhove MD, Hollingsworth TD, Griffin J, Baggaley RF, Jenkins )] TJ ET BT 26.250 78.515 Td /F1 9.8 Tf [(HE, Lyons EJ, Jombart T, Hinsley WR, Grassly NC, Balloux F, Ghani AC, Ferguson NM, Rambaut A, Pybus OG, Lopez-Gatell )] TJ ET BT 26.250 66.610 Td /F1 9.8 Tf [(H, Alpuche-Aranda CM, Chapela IB, Zavala EP, Guevara DM, Checchi F, Garcia E, Hugonnet S, Roth C; WHO Rapid )] TJ ET BT 26.250 54.705 Td /F1 9.8 Tf [(Pandemic Assessment Collaboration. Pandemic potential of a strain of influenza A \(H1N1\): early findings. Science. 2009 Jun )] TJ ET Q q 15.000 40.420 577.500 736.580 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(encountered in 2009. Note that in this case, the zanamivir resistance information is contained in a linked reference, not in the )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(GenBank record itself. Although we can track any positions character value with SeqMonitor, the metadata are not complete if )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(the parser cannot find the appropriate tags. Manual curation is necessary to keep the system accurate.)] TJ ET 0.965 0.965 0.965 rg 26.250 428.908 555.000 304.877 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 733.786 m 581.250 733.786 l 581.250 733.036 l 26.250 733.036 l f 26.250 428.908 m 581.250 428.908 l 581.250 429.658 l 26.250 429.658 l f q 201.750 0 0 225.000 35.250 499.036 cm /I24 Do Q q 35.250 440.158 537.000 52.877 re W n 0.271 0.267 0.267 rg BT 35.250 483.512 Td /F4 9.8 Tf [(Fig. 3: Temporal and geographic distribution of NA K136, a mutation linked to zanamivir resistance.)] TJ ET BT 35.250 464.142 Td /F1 9.8 Tf [(This mutation has been seen mainly in the southern hemisphere and tropical regions. Interestingly, it has not been found )] TJ ET BT 35.250 450.406 Td /F1 9.8 Tf [(yet in the most thoroughly sampled country, the USA, even though it could be found as early as 2006.)] TJ ET Q BT 26.250 394.687 Td /F4 12.0 Tf [(Conclusion)] TJ ET BT 26.250 374.733 Td /F1 9.8 Tf [(The primary motivations for SeqMonitor are to facilitate the identification of characteristic mutations for a given sequence set )] TJ ET BT 26.250 362.828 Td /F1 9.8 Tf [(and to detect new sequence variants as they emerge in the public databases. SeqMonitor can allow the exploitation of a )] TJ ET BT 26.250 350.923 Td /F1 9.8 Tf [(growing body of general and strain-specific knowledge about the influenza A virus, as new site information can be added to the )] TJ ET BT 26.250 339.018 Td /F1 9.8 Tf [(system as results are described in the literature )] TJ ET 0.267 0.267 0.267 rg BT 233.243 339.018 Td /F1 9.8 Tf [([4])] TJ ET BT 244.085 339.018 Td /F1 9.8 Tf [([5])] TJ ET BT 254.927 339.018 Td /F1 9.8 Tf [([13])] TJ ET BT 271.190 339.018 Td /F1 9.8 Tf [([14])] TJ ET BT 287.453 339.018 Td /F1 9.8 Tf [([15])] TJ ET BT 303.716 339.018 Td /F1 9.8 Tf [([16])] TJ ET BT 319.978 339.018 Td /F1 9.8 Tf [([17])] TJ ET 0.271 0.267 0.267 rg BT 336.241 339.018 Td /F1 9.8 Tf [( . Currently, the SeqMonitor web application and data )] TJ ET BT 26.250 327.114 Td /F1 9.8 Tf [(warehouse supports the H1N1 hemagglutinin and neuraminidase genes, but we will be expanding the system to track other )] TJ ET BT 26.250 315.209 Td /F1 9.8 Tf [(subtypes and genes, which will allow analysis of resistance to antivirals such as the M2-targeting adamantane. The system is )] TJ ET BT 26.250 303.304 Td /F1 9.8 Tf [(sufficiently generic that it can be adapted to any set of homologous sequences for which annotation is available, although the )] TJ ET BT 26.250 291.399 Td /F1 9.8 Tf [(clarity and reliability of the analysis are highest when sequences are very similar and differ by few or no insertion and deletion )] TJ ET BT 26.250 279.495 Td /F1 9.8 Tf [(mutations.)] TJ ET BT 26.250 242.892 Td /F4 12.0 Tf [(Funding Sources)] TJ ET BT 26.250 222.938 Td /F1 9.8 Tf [(Development of SeqMonitor was supported in part by Genome Atlantic. NJM is supported by an NSERC postgraduate )] TJ ET BT 26.250 211.033 Td /F1 9.8 Tf [(scholarship. DHP is supported by the Killam Trusts. RGB acknowledges the support of the Canada Research Chairs program.)] TJ ET BT 26.250 174.431 Td /F4 12.0 Tf [(Competing Interests)] TJ ET BT 26.250 154.476 Td /F1 9.8 Tf [(The authors declare that they have no competing financial interests.)] TJ ET BT 26.250 117.874 Td /F4 12.0 Tf [(References)] TJ ET BT 26.250 90.420 Td /F1 9.8 Tf [(1.)] TJ ET BT 38.132 90.420 Td /F1 9.8 Tf [(Fraser C, Donnelly CA, Cauchemez S, Hanage WP, Van Kerkhove MD, Hollingsworth TD, Griffin J, Baggaley RF, Jenkins )] TJ ET BT 26.250 78.515 Td /F1 9.8 Tf [(HE, Lyons EJ, Jombart T, Hinsley WR, Grassly NC, Balloux F, Ghani AC, Ferguson NM, Rambaut A, Pybus OG, Lopez-Gatell )] TJ ET BT 26.250 66.610 Td /F1 9.8 Tf [(H, Alpuche-Aranda CM, Chapela IB, Zavala EP, Guevara DM, Checchi F, Garcia E, Hugonnet S, Roth C; WHO Rapid )] TJ ET BT 26.250 54.705 Td /F1 9.8 Tf [(Pandemic Assessment Collaboration. Pandemic potential of a strain of influenza A \(H1N1\): early findings. Science. 2009 Jun )] TJ ET Q q 201.750 0 0 225.000 35.250 499.036 cm /I26 Do Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(5)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Influenza)] TJ ET Q endstream endobj 182 0 obj << /Type /Annot /Subtype /Link /A 183 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 499.0358 237.0000 724.0358 ] >> endobj 183 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/09/136k1.png) >> endobj 184 0 obj << /Type /XObject /Subtype /Image /Width 269 /Height 300 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 269 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 554>> stream x1 0 =ll ּFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnF]C endstream endobj 185 0 obj << /Type /XObject /Subtype /Image /Width 269 /Height 300 /SMask 184 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 269 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 79640>> stream xgu zNUu9͝ r"@)ʒ%ɲaע-{VrxWZ[dKkZVXI%YH `fЩ}oߞ;~~?\7ӷԩϩ;BD74" t q~h^v I} Aw2o|{kv7t nAg!@I 'ZgZ Ǽk]eC^ /6ՅɆ b>;!kY3Ej$ P˲jumyX`"Mz\_jOwې%䫁ڐgwչ~i/ykjmCv:AeCi= ïKL_rnv=Y+Abk _5ěbw{ߟ} >8>{W|ǿ ?c_|Чܟ-?=oRL@;O}>~{ګ n.__>|=/~{/BDOxwnr>X5}s+?G_~_xB^?ȗo?w[O.2^k끇m(IWH'5\ ]݆4y%ЈH bR/eSuԡ]m*??ve/~Yihg&TS>3ߖG>yc/]7=co~u=s.ێղ'~]#}}kmϖk͏B?q'#{GώϽ G'm3s3s"8~fs>uS~O~K3K9Po,]}S_}MVw?{MN]᜽7E+f;>79yWuPoƧ~ݸΛ'?ǿ~@Юc<Oo/k~'k7g $WG^GO}_y^kZu q+/疯^9$ C[ߟahHV߹wzO?o,u߷cOƩ_?3}/~kx뾷Gzs}"4/?z|)xb?◾/^?^^^(~s=܅wox>-%+~\/B壟x|f{* lv`M~|l >msRs.~꫏}SvlJ"ũſ#3˷ܟ2pԏ&f?^{'돽o'ѫ툚='j婓oڣ'Z{/=Z?mo|)]?>g<)OG/M-"z|\=._o>^m` wYWx5_J`n{wZ#"\?KKN_2ݑ]7z<ܛI;8Go?|DG9c=JWuXE/< me2=;-'`]=#=6)h.Y _-D pnC46ի}\?|խGjxn _ \ȯر鍷^75o?y}YyQ]ooz-Jr~xM/xݶ86Z}gNO_?<'/̯oٿ[N?őܾmϟ2vey@OM~v0>wQsϖ}M]+DO: c}k\)y^G_~pR֭ݸ•]$cûG鷿O.o=md wf|ԥmpeqd w+yW9xpN\TD+z3G ]v ?}jo޴ɾ\w̯a=o"'0Źҿ=SKWADڵűl۔?uiv;_w3G^x-1+5o;23ocK-w#/^ڿ}uۇ 릟?n`6^vz}/|',L/a}s7\† bC<q@T1J7~kp}{!p?НWrq | Dp~#_;~m]=Ǫu7?\Pa#Ֆ_X:-o \vF",GXLѓO~if7> O}@H_:"(/kp0oBl=v;qGߍv0;nRB xxFD;j@Nd}6A[Ba{Coͯ:Qx]]SBxl}B !mG8L$Z ģ+0CkF`ˮٻxf`c.D@x  \\BPjϟbO)$B˂sPhM6=  5gmCEg,,,AP^]e`"4i %= @&QmYlQ^D$%$F8ʕʊ0gX-.~BAWW6;$CX@[&,C6ك-PyAk`/6jz%m=0>m m<m+آg-ː"fKKNC6.mc,&W*P T =)yشJ%ܺN;@"8v FF`fi ǁ!abP|ls9Cׅtb1ںX])tHielJpq\/_|*fP#G 텩)ؼu@DMn,j8="siPFerB<ժز;\yemf&rMDB>l:~p NLF"RZZ2deM⢑NQ0qgg׼fնٕ+UsZ\4.TyC[g!@K!ҙz܇7t儷w;n3 m $j +|GF9@$!ѠsѶM,s\[]d+A4mŠT"@L j@ss@(&m  5pd{- V,?5 %.tv<9vmHF"BlDzH$׊D$@nj1wW.^`,Z<1J3!0Fy?d BU:@RD/mI5NnX^[j,06a A7wpo{ щh|пÕuY\,g7"ǚ"4 y~˥Lxc{Y }}%t-sC9=DdOt^jҥe?B~aח jN~5|W3c3nC]^zvl$3:_ ݮ5݈ 8lPjbX{}%a-U;Ǯ+,0$HXE a:tA/OdF$kGFr :sKOVJc njgؗ0 W"t$f[++ZSn Rb& pƗjח1 &Wke/cR9jIEJѾtҜ4&#㦦 HGJ,lvKFǥ}h|>עХr}v mnv 5t^Uɴ"T*F32&'I\n֛XmE4&]L f USGd \%Г|KRgr3-?Pf}O)OZwܺ#{&"ufRn;Hr/. DRҒETTIFz bU"gs(}ª}01Vs|DD"Ű3S";$Ɨju+֝ބSڑ .,TTBlY|g|k.8X99r-O͔V*mM{frudEMz?66sQ!@q-oM;A"#aw~cܡ gp=ͺ:׆I|{or2??zn<ܻn%&#ZO4mθҡ-٦+͙.X<*6db3SvSjj=yie7SS+LHo/iB\*-5w"yX)3ZTb=#=z~(iDua>M I"خ$5]yllf{Smz66gc Ox֔bCK j9l\ŌY9SHp5וd{uJũYޡaMp1sޟaN6>'͘ : ǝ-XSHڀ}]lWj e ;v͗HRZC陿䗶mnI$ʮWϚOׁǏ|kј|=w׎5^:=x-lLD-/LTGݷuK&%@۲*".-[t.X왭Omnz `n Ӑ+V"HivgyR*RlpM70m;z=7˫5'f\Ƌu熑\`@PjNEuᑊxDdrPɹٹҡ99/T.J¶jEႳΑt:F[kwR{rlWS6d}G}Bt+A ?.,nٙUjjQ:'5Ǎ$M <7:Ұ]HMԕãT_ԑ#"nC`щ 3Qqm;v=yaRdO8쮻cǎi~Y\\x<^(3OR޽ԩS{9wΝ;=ϫjx|zzz>&_җ!O>uԛ&0McJH$JnϧRbrl&v?Ng MIl]j.XуY uF73ĘozRg%J: "s@JIEC .tj={t_ZZzki?77Ɓ:泰Dvn"""3o&rI=5Ǜ[r[LLә9,[6?HoGjqL42d@)%(c0]bD8_6//׷qk":gp\]~Q1T\E}q _ A*549B=ٙlDEt0wc*::8]̸=r!Í&JE*?C( z %!٬NܵQ" dlٔ:,FV^ƻ=F=JIOJ55]:> hj\yxgLI-gD5˵|R4M6ktu4V۷oO$X,T\.NQd2W\ᜧR|>ﺮyLjse2D"^hb|>ZTJUu7'_=p@6go9%Il1u| "jZtGrwb``j("ڞ 9",լs兢k!qJH"JcuRD Pz$RRs83WԽpwN4]3lEyd\Š :{y; j k˖4K)q]*4\F{cKeZwe- 97lM1Y5Y';{93 "Qӱf}Oj}lo#cfJISۖOty4 qM]O*h|XأhO# RӟړPrʥ2[UUn3Gu5"zgn單B! ڽwU[l1R)$.F9'My*4DD b,\$j (TL+3È`p!SՉX>oPlsJOT<RD" U* pzrÖ?8#2D@/77gb-0DEI ilTttؘ)5JuΤlxu%ŋsMShuǾ|O_o;R}b]YnV3;r%7KZn?|vw?f{VX*+]c::Nqeee)S{J!c FFraq.ZeGE4nh! IR9KuqM&RU?Ds7w9D"13~mK MG,Kmi #/oI>[f_/Z, 5͓ (N_G@ۓn텕RFfXߒ4p2Q 9 YCCr&'cjw*s"bhecF'.-낹j:qH{jÈJulA63ʗgJqbilT qlY}>b&I % 6>>Å0Mcii)+z}v "a҉biƒvD _>i{>J Wa( 4hۍV7hf=SkDhj 1-!Vb9[RƶN# $"NnЉUJ1D:E'uO8ߛ ۬S/9𙇦3q̕o{{O/,++ \>Op,<:m[6Zr_P S؎tI%l[ sDE10ta qD`&O0DDWўʘtۓ[] mrZjMZӻu{|)nb٥td{_</WۆܗVR-74ގ-4_;Ѕ@o\OB2\ @OR_8͇ Jŵ[w䒆Vh.ghٶ2Z_nݞy(GH,L,=I 8#"TJ} &7v+/ڿmtS.kssΜƑ2ihkrF$Ct%Ktiys߫fjqCRyʳݦbd HEj}Λ04Mu59kz^D<1NiM+{ʫ^<1Wnnprm>\=S^PD+r9FDiqk P& lGXlTxҳmGhBp.=]zqmwl729c8)jXnDզl=~ͥḚR)Ch†#`[+ZT%l+kLgm4[VT ;4_]߭lߗԋd*ޞfyuǭ^:rv"8MćX\Z<϶z:}z.LR3@"g mm^BJ% H"E#* 30wy/i޸g<>^r\@/j[V zWK:%De g LdTVrRMTvcO jɗ&VP*%1`a@vpwطvLZNwĭk@ (1cPs榤sۑզ,V/,}\8U 8AOt)\?4@OmsHZM.4loBR1s|ߐͦپ~OE  Y6R ɯnݒcu+fPf >\5]0@ZDLD!:NRpnL\/\Xh1$%d#&M#)ny Z#k/ߵ/GA+ĥVf"C\vm󛇇'&jփkR1|Ho""LǍRΤ X.I 1/IvM#C[/lת "蜻ù 0H0H&]St< Z4WhVp@HQl6#9 Pr53 b)bKH"Ig_.TD\(m5l(:J ]`|Tl*]J^~p\A*:נּ4<(c2&Iܰ1̖"l=9ןXqd8%BIDyu9cr`̯`Ab/BVBP/՚d<%( +)}sNDT'O>̳۶o$l"e.P4 Ct'dD(>AJl )Q\CW5qVw\3'uR&zRz4,%P:\Kq]}V}F_eu~'tg._rvdfS1LhooEk7қ:y"8{/˗ ],..+ri`ЍJ<Z)W*9!2hjGj|7DD y{*|NRK˶ "ZlO){؞DDTP]SEgJ.8Vg{--C" trtiz ycs _XL.1jp#4+loNWw8vi?yefD';3[NksG;W[[aJUm}CQ zRga A˓o}[{ .FQ!B. F { dC=}+H6*n?0uy}q]1X5g߽g`bjMwBcow%}^q3ss@?5h_%Tyf+Bl//ڒi j`7c M[]Y1"-~To4-6/ES'oLY49jH1}=TL053BTF)sragCI & = J5Juypb xJ)@|:+U f|'!) Ϫ89< תw5Y12Bl~B7Tnz7f[)[CUry|kro"ixѾ޾X,fǙ_Qc0QMnUh;qrؔR5]g}q3 h< 덾xۮc ~q&w4}[z omGGU˥vvqScZ>2I \-׌h4u<“J.0=:0Y˅>jS <4uOc,GaHKsDD9hmWl@{%^Q}ۛ;JR OMlּU |d0[~Hֲ& M|ז-F$2W&J`|4#ϗDj8ܨ޶ Jn@*7*vj#y0Ж o9޻/֫WՁbSLI4cр H c 100C9ʖ@%RbjS\K7w}dK$uTwO{ַ^^/dxʶ$tddfRTDJ MQTBH/`,)-:XnMG[ z>PNk{\6d%nZ/, UziʍDꩆ{4g'U }/$%C,bRȁ1+"P!x\qy9)Wsٹ^'%MOG* u7fb;c\68KW+;F͚Ld,M**f<ӧ\8ff^r>3J(9a+`raƂkČqv""7,-/tBTEDD+84J2Md^ e\;>\XڞBȧ6*7,IhZ}goOf|9Kc|N&Kx)A$ ̄QdS@d+IwR2| lۆGqւ9/lE$tGlYIRC./ƂלZ/hU kTc1HyтX\Z/uNѷHL@P̏-2X-L@ɘ974E񂊩sbiTBN!C%v"!x4ꎂDW_xJvވ3qƭ'ݣBQrƍ_zy.7MF $RH *@&cjVt XrKD %AaZ817nZ˽^'cS)fAmJSo08}~qahfs49ޚP%dʡ/*c,SYc0 iؚ8)T,gRBM)g,bH( 4)xP"fUJJFtv(MfZpt# Ѩ"lChM&Eo,W7 c3q =`0XZZ FԛMiw:]ma̎6?' X >vsgBAX4tЬ7b u!ryi EN8&~|n mhkW y{I2;wdj_)Dx>yfR7EJ@ZR&;IoзLSu Cx2FDJR6\YIK$c@̢ZcIsaw^R7}Ec8]%Bf>Yw=I@E|W*C)1o+? !)n'\>c1gJ EDC5a_2S]$)6\=5K ޛERQIox'Z9ٵ#꺪ś1~]STJxV"AeDԏ]mvJvܹ^xʪeZmAPV=iBHN/1aZ鱕\(SuDaت\f Z.B/&H)Ar)]ǍZ*CVI(Q@MjsTo.:s./7i f~NҩMxf')IJ?}~ް3 8Ek@m| v I]ɧ^p=WH:Bi]kPJAEm(DsF ĜC 2,Ul56ݱUʥR͙(Rhz]'8Bc?F1nWSb2`[BQݸq-//hw:Bi0)Tܽia{0R@-2Mjp\t[KMA峧K8ewÕDSGhd!q4y\sM2tPlBAjF(q cvѭ*13T%vp`z0{qrr8pL.a0/嚡cmJ|WTB.Ǝ]Y<(QR &($ #А1$ !yGjR>~1MSƓ٭^}g (4(9bS;'֙:" .\1Hw P 3 ?? P|gTM;/W*PH!xCO q!?YTkp8ygwܝ*Q]H0)%e8^rwCUE#; Y 2cl4[R1$xA@ewZѭ ۵Y9'0KnY$GcOStTt yWBzRDFG.DSU/4U5V([Y Ec&`v8,H) bտwSw;GRʤ6@ ?J!]#G߅/Ovk USQtP`B0T8-vcƫZ.f3OU+WZ3u 4MZr~Ħ)LD(LJG0ĝ0tޤ(w!lln*z֭x1Ur|֭{( pvJrky(A+1 FnUZ (3EKUYt3#jGA>RY2QvY(eC5z~bEXs-y{i^໎#I,R(ZV櫓=Q5UQm˖BQج6R$P=gRʈ (PTu0P$D*֨ ݸr3]#&D߽-s)p.V |\,sԟhI$@]N1| 9.Ӑ-;oȒB~kn|_$$iٖtJr,b$"UQB"4B<"(s %/G]Y x8>Zp]$\֝ƪJX:%Kv%(~EJg0WC$bdeY2׾8=p0h4`}mmWd> 8\YRn/eK}fjVN`lvtCm֏"P.nfp|\/yL H 1 sER+ƍq'~gYvEgϞYtU)1.*Z"3]׫%8sq\ޅߛB.!@ʚ,?XUFmSʎ֙FPw5p„yƟjÐ>F#~ثuS1bJ%^3 ×_~ W_}KnAx҉+bFF"!A&ERSSPIkMIk^k`2-Av*⚽ϸȬ C% 1d?請16N_ ucVֻS`qBntP89셠P/ G^tM,j ,dUW>yJq>ԥۇ$KD{u-qDR4z>]P,So*+\=yD4`R*u]/8N=y;VRVsz^ۆaH,y LE"))Jg;]qw~wݽ}rA<|;/s\>lWMj@ݿ~Q6?]_oqjgwߕgeQ8V$JIdKf ×_~ٲ0._;s>|ϟ;%Dq B%g}zIq0w'^ ٹKߕM( ۻs}U I Ő 9/'Q:h4TҞtR0E@)>Eq$%0N  c?65X*XS~R*.ZZc/;ù`[mKIfx? " kk9~瓙7z@BY(zhaWU+Wܽ{RVx&'4RG3TWޟM-8#\(4$\1T &<ԩ[; 3+k1%;H.M0 Te4WWjgOojd9riI3L1i@ֲ'Mxf[+z*z$ ԤFjR䓗l:yrkmmΟoזAH@ØIB$P@y49hhb.% ~h6 XԼŘSwth^r]Ey`꘦0LurGF&JZ&KI(ϝXEԸ7 b뭊Z6qqȋX֒'{J|TqST%tf{XE :ͭsۭ~j2!ݩA7f\,?ߕͲDS]DI/FqpT jQqPA4 _Z^Ha~cR X 5廀E]FE!a6VN'QT!4'v1'ԏvc7.E z!X+A*J0-✀4\#DtGUXK^ ì:|c2ZCHgb&2wa`\(+8:P<^nB&3gr0 RK~.u]Z#oR8^|޻w}cc6A˓$0J҅sΟ>ycp38!w}: ,/{B.ց)1dnkyl8 b?䎡\/<,ްXyf(뽀 cW? @)8 X4!d>h|@]AN}GN(jj5bq_)$aȤ!J.FԀia8OwbKD~p4*`E1d%s=qH9JܹfRJgW*0hR26KQD{I6`h<;0}wWuKr 4kS.wk :Wj֝;x㳟yK>ƛo>O'SB)0B tC+^۶߅x__ַo~3 C˲(%np+/_?Kg/\P !6֝Y2^KY;G:=Ɠe*b)%)GJ.|)d&K28>)KspFD=)'T2Hv”K}KE 8AU"Jx,Z4 (HaETIJb I)o~n/${;cLyVNV$R?rڝ~ɝL3PCiLh%O'1cʴE9`Zk LVɬf1Nݝd7z0bK6+յJ'Tu8A8WW[gf٩ӧ˥R-H)Y¯=r}̙3'Ozil۾sn Wr?Sh8wٍ͉ۣ 5RTjB UR꺁Rb${;f\21.v!TX}.sc#rWR?Ʒs)CUg"9Ʌ) iŝ[lW)X<4 .T4 O&O@X#Z.w.oMnYĆ^ҕç79L/hO9qUJedN|Rla3!A>܅FG%Bs N, 8pBJ^as] BXT͚}>L i--!7JJTH!Ga) :JA^/Wpق 5jtX2jB`4\,%P Aa,B$Śz q<ƞ[[>gi'e˶yJ̢\4Lz(*HGy2_K鵅 g $SB ]i $ʔwe;Tsz+--4pq=V`o^=?*7-E)뗯 C7{IB.tl6RD}1ygNt_2 76f>7UAE˙W Gh $~U b4b!-zKJaTV|qDym;;;B(Wy0<<lcPJ9٦\oi/?ڋ6~{ғW]N, UH|EA6 Cٗ\srPns_ y J)ݷNx>gK{o2院(yaa"͆s|f̦hSn%(Z4J5wۛFr0s)1ĵ{yEUe"W f_O*RJPTD !dOw-fb\4<0)%;jT;rѴM@ .4r8}th~#-.Q훷%2d\@uj8UUz3{;+͕d+yV_Og@T:fxJN6~ӟFDBh:!/( E)J@h{SϷ ÕmJ߻;}'^}啓ۿϋWnMNY|a6 "95hN͒YRU1j26pP2%n`1346tڬ6Ճ.}=g+%"z}uލl&g30U/]OK0QxTRLsx!ΒXT=3@DTlD:@n3m<r2M]iܛJa}z(2qdð?O/;Iҝ(?6L U-?.I;;Cja5ݱ|-NB>vǗ2dΨK.9/@ 9\@BcPa1w)"=m*7oT\HZ$8RJoܸ麮i}۶/=wfo?UjΝTCO<sL0UZ̒])U]vg{AI8V6Ɣ? E!v b!$+uฎ'CdfZ}pOyrg_3.ڛw6Oљy ѨT3RMkq+Ju*7v{}۶{ݮKSAl6N4*?/V1dnݺ/h4y۷mC}M FSHܻS֌O_K'Oǟ^ ."&dwb/?_];gmy_P*8g+R (E3@J2hh #!eng9\áSeٳI/tu[޳V%۾ùk%w3y1FD?b?ߕ wEGa Vu0 3CUU M4u0WQ@(,xn1fLS4t (]EDDL&nZji5*[s3P,A`&Zp8d@X)$E>d`%H)p_)PB暧Nm) XX&h*TCqjB6mݞL˭j2ouTì^'ͳO}ncgݻ_ ڌk7~SnZ`.T5H8#|W9D  ʘr 2Ï2fs7iν4ˍws^o,;Wǿsp$YLG٥!E{R@5bliD)E&uR)㑔R,:+a\rJ.*B3>؃DXytȟUJI>b( WҪ=Or @wkk餺vz2l*&ia($׾6WV[|Î{o BEyV]ME14R)/.Y0'V a٦spp`4,:=),Lȋe)R Go=HI8hm,[a\y?3nc^>؏s=QMWQGZy ǾNjJK.||W?XnKcgjWt",3{llUT ^8(+usik3Rp9b\﷧ɸ*Hqx.B<'/EABՋd[|(9GvvvfUT5Kww Ţi'{mjX@afS@dFϭ_սy4.rZǫ7 YfLe4T,% .Rws}t3OnXqcG>a%C f$ڏJaߵx]қ352z>['6ǁַ~?^NͿH~N࿈bFc#ǹuQ$_y2\ avV7(,NR*kZ36Ý[=zb}]qΝAB\~\@\8wɩ{AЬVa<4R~`J.Uþ^֓1ܙ\p. c?֪6Hd2YkIQ9 63C G?kӴ&'>=4sݟ =ӪO7-amn]^t EBweS$WTm߃~ wɹKJ+Hٟ7^iU9xػӫzdn)H"Ӟ^i|VknZʆ~{|fdSOn\N\~]$paaͪdZ@K hD0+͢[m܂J[[響zQktwo駞 a )O٦;ڶUMB3rq8 )Q.6aɚ˄$bbPfgJcB@kE#`s{9ϫz__ЮK=jtz?} TnR45E6.|,N"2wS 6`·7oWfIt~15@YxlK<PSeʥl_k]]bO'ȋ~Z!L~)n eEUAQQlf<ߕ,5p}"&Ib u~[9@uhm\\8NZw-Lԥ/o(Rj׏fQwUڹOl>{ FBݬqHZnXDƶ$7onm/}[]c K<Ԯ;;wh6O{~(( :i;kpp⃊ɮ\~]ubXߕĐ-8wʋy5y~sِwfSA- jԙwpa?~\m^OqqnZѣg< w<B%ܟZȤj1dgUjfjgpsvJy}6&Q-mg(ѠhevaoQYYȵgIJ zZ#!ݛ=).2px:L hUEѿk0q*{{Vn?6$sK+WƳx`کz(='dS zI, ƊXC}Ȋr.xt|p~h( j%;Yr1l'4<ש+j5IS J8aK|sxз7oGm4 M?czwA \ (0O\haZ>!:D,OI$[8{BN#( XԪ[Ei*@"߸}(E>*YP0jRѩ%ރbT6g*kwFҹ$썂So`'@ĵrzHVjd>MRpp΄qwf^?`iwcT^Q].].hTw0r8g`2 n[zvj-tJUiTJfuU,Joq{s* fރz,Xq? 5r,qkvuK/xp2XDQTB,;AQ%qvVᾷ}{Y6Ϯ%|胼peoqD'_3 :t¬;jpKm|ud{`K ZꕫCO&B'i"R+-1y\* X^ ,۲$bA> ^7ΦaJ~ 0'O9^^=@9溊np3\_srupa r5I7x#Mӗ>0 o޺=L ǵZm>oFٶK@{}j\)7Y/ۏ)2r1̀3 yA" u`y;YIWQq̉I$qwį>$LS!$!i3i:I\YNdh6"?딣XX )2@$U ,/'DzIA%*C.@)W(A~A-5˚*`cI6N1,^@4@KL柾r0\* :Hv"(ҵ4N90!1`6gٜ!?ƯoR)@(ňyP}#XZбX)_?[[J{wgѣ$IjQ.w]o=G]<6?R _仞cXO]n6[BB%o+R.ǣٍ%vnBn-X]64.w$m]c$I;+|ՃquS_.!dL4'l pLŶe/ZQLy[QK)ZI D Iˎ=Omص,߲)Υ 8r1ŬD6oOAӛ)*)Ĵ.LMBKNIĐBg'NV~?HRӕiM@yfM_պ8% dO^T='#jp? fж4N667~`l6O`vȈכVƛ?m5ۀYe 3gt럾83,.@<]oQJ $ه6SgsՉKx+L&$ 5x^ ZZܕL fIF 0 )E ܜsw|t@eGXHnh7CEkiP (ߩbjv h\+$ 3-)UqLix9oZez q߸p@ KS*ߥ&\JЀ}QpTsegĂw$͟_dsFB8 c L>cF>EV w}V4jȘy:F'⹼b,_nTβ%߃ {}pws0^ӗ%<FQŪRX$!?GI*D-ǹqFs&ID,D" Q= y:ߕMKW_ yB0,N#n\OcaI \WarWvfBXYߕIX^3"j'.cz4L2Xgxrnpi%\z..,w]XGh CSȸV.$I^z֥KTL&u r ȷ=@8$I_RDZOihTU| LDp20@Sę1V][ZO'@^`D0$Z3\8/^έ99|ҏ T~2FѰ4.N48}F!U$,tov`%W\bl.oi$T6 ՝\tǑU"+kZ5GZ}ey98I]ǣA v Ԭ:Y"asFfY[2332c4*gW&sǍܹY}Y)OHv|qbwЏA)VSUZFQg !͹$k9a 5|b|2AC.D}*D\T@wQ;Ȑz!Q![l%y*SCW&J{7ooM҃+nTVo;@̔|UT]E#4^1D BBaW^?˫YJ́('D 4RD<#,IX C; "| 8l^4FTz2].%!1nvCkws)FBߥﭭ;_~xt\f)H!\8?(@aZV6eŸ0 iwgR|F't*0JulCۧ(I\.TD$axo۽^ I_.T=d}9E@1uTQ!1lB3G(FH9[SP?'xYm+n/)L#]3-βu#r8K8+א3ߕ)V\#mj[YߥW<͵َm$}f9 d[+zpwWJ9K?]\e-LH"d2TskqG;[{Wʻs5ٯ A+9$ºd]zt4Z 8R1|R>D\V"{0; {nòJh40lۜ19cRgLd LɃI!QP[,Ξ MG?叽WyƲjroL,\<5 <ټlprV _zc!*wV?ZO5KubZao(9:q eΕMXuil aRbTbΫY Q(swwz0XT J{8El>Ig9!nt:DD@H-Υ83)e,Y,8RNE 3STwsǂ? <9Z8U蘟Y_%:=M[:f#Kgϝ-Wa L| 1hSowk+U"!,ڥ$R2*R-pr97n '!jvI{<)|WݷTf]Bc(2dK` +Ջ+n/o?xxf7{c>]è.u:Νۂ$C6c[ԷXE& Wgy41b= 5&ժWMr;/GyJ[vhV۔ z:6WV;v%叝oی!4{ʉ ?}+\D{n*; $t쮖7S:g;7vGǓh~mǡ`2}+NW?qʇrK<a,##^gI|"d9gW4n9qJRz]?%}035h^ gn>wBP3~u4'{ƚ/Fi߱I 0 "C r۵p-FcٽI ,3 cD7ӨFW㻸oʗ~*p]wu_# Bd_u:*@"`(#]c<Dd[Pp^2ς Dwe jY#"0d:8 KUJ.Zw0~T7|WujbƉɢћ#$ߕ(cw,4sjj~eXopl1-@ Ø16c;TqxwYCgAPi𭭳%lYl:sN}2M-8Nٟ#CX"f/jRMM+Ke;(< ۞L4gwyW^~]1T+>  ]{/KwUh*Ny}[e\rD XI!b󝵺N$Z|j_ixG#&Df$$}ib>>| 1,ʓٌHR @YrNFrs%qq ӄnAl8AX"y_./_K83 p{~xpwHm`^oO֭ru:|vFkkkݻդ~Q$ѵ\ aQ=ZZj.K`qJuŋmyo+NU3D"$Wo!d<$lg_o|wΝȯ$R]{$ϬVwA0ل~n."h+jݷ.22Nbv:{F+Hbl@p-qx0O8MBߕ&)qFci;tj5!N,V֯<}bm6RVuyA۝f|Wf=օg cQMY@].៿b1FdQm̓8T*m$iLmH$P,@DZ__Ϸw›3Bxלr iW"MB8nJY<%x]0 G.]JLV%gavnw^_ٖj{\&UYP;T@0 O3woKch^|zV8"1ĒU"]2mo~˲tw4nmm!|>h4*fɶ!{y#/>[%sNٺrJ I!޻2]ZWwυQliǓ}ʾUyZq=>6Wu2fA$Y_oTk鄱+ /ovX歹?x}(VQ|ҹGQGTyzӅHe/>_ѥr+6'nwJZWVB?.u8V._c_}[?ME"8 C^k/{<Ξ9W_||K!E,ÒU֧>ҿz̲WV_fg)ۜE@3!1ɓ.EẑސHqZ:G’܍z[e˂!0d L&2#۲`wʼnXx*-ԻS|mmvM7Eo,Ue^w{dR=x]بl6[-u Q"wvd;`@/jl~ԙ|',* D}wqixMIٱyq{#kkkٴn[\غp:olgZܲX9̙;ַ.2n)/? c*[2r-RǏ^\w9H­6!|<>)ET.ioƸ纪 V`ڨ58Am9#Ј=.tfq^>P: #kiZp7gk~ʅl!+H2~ce? ѠTjW9y|WuZeGA*dTvm-&FvZJƵ3ok/8YHOZ=*j-pAms' oD FiYbluyyom|.z>s^EN"9X|3W?mewe5 gno<.bBJT d$MjVb!v|_*ō=:Ox= +I$ϓMyx};wweDb@Υ38M-q'$]ǽ;8AҊc9 g(DD!YIw@=oY 1v0[6c.D6yCbę䑑DB>!x|m߻'XYn ^q\7MyZ˵Y ϸq|Yv٬ R)ixQՂSާ]y2͒y$*[zn|WRͷݻ7˓զDWjCDBdFDB1U wew!>ޓ^W!&KΜ~=J4n-b'9@O#r$DTd Owڮ[B@K{<[bp@/,]{vtڽ|߽r>)"̒y($BuO}F=D0' ۽$̢t mRw]hB,8ڒ$CR$2%])e.i.x^N]? %{%18k/$ay.C!r~Ckrw(|Y!?DXJ7|) x9~!|Wwz+[.H }~}$˄q "0N;Ƴ>;}߿~:szkw ̓1yGTn2Fz3ڼUr@<(@zQ/(tAӛW>2N?KlW^y{i џ[(_#- 뾝aԼ~#I7~0vv;ڣ Lc]:Gߕ, TV|>|5͋`yaT`ľc1}k6Oso,V-و셗~=O䕈']d9~K!ͮ)]gHDM{8"\ ~ RcN)E*[YwBK' kya@*& LaR1>%b0gsA~,]UJ900%~/>=>Ǿ_={ғ.ι\]pO%"JQ b\Mv d+rƘ^G,"G;RSfIꀊ_.Qo|VA͹"p^Yz@h?"Ole&IKd8򥯄/RC/z\?yfR\|ѱIYLTg CPy1J$yV=KQ?Ab" (I]z@F2V#JNeH3y(B'\)hLD?r<̇?x]jy]d gtZ֑v Kg8Ϙt(a7:~$K#"TpUYŵ2KkNY@/<(&0u2$VwH[&45Y%Dd'.dų2BN E+;,bH]ϐjwm )$<-|^*9oVV$thE|uJ!VA=|j\YnW?*ߥg{Lx|g eJ KDѤJ/sF7qQ8Gfz#XȬh8ej(ކԢhfBFFwT27:H?( Z|N 3^sCҌTo"iA͐r-)S 8P (GV P*(t̊<*!!<R(4DzJGm(F܋DH: S*?Dc)%%aKeUC+Z;8WJ Oow'\bQܟucq RJ+K",jx &Ռ9E<ҌEy~.j),\K0S, w)]@)NOA@aaLI.Ig<30fBBGQ8IV{'%GY(5C|@1_2* *+^) )YL$MdEڶuzp2'Zf8i՚ĐS#o)Y.V5O4jQh'\H-T4* vWʉ/md,DĒg-],`WvSVda` @UkvҦ.lVL\͊o^o*C)Pm Z %UvB#0$ H|/!X?Ƚ +*Oz$EP*hE۠7$ Bџ2[]-{xv`]œ} t]Heem e31~IA * k!bֲU!=\>u?DRFz-Vg*# 2:ĐZt %%Ȃ "m ( URuC@qC[PrR!ڪo.+ĸjS:\kaF?aߡPʍ* 3]T´Q;ݟE"Uy9veȁN͵R c~daBMPlLBDAa"*{jS烐ZwB.4ty4W s9O8f`@ѧYyҝ%$NZAYT(B²t*"2+7-: s%B6 UbB욏UQ{)=ÂmyNP,9IWҷ/J[ÔtsC"mHjL̈́ghe+Zh-xQeY<BJoO3PBF{EGx3t/,HJΘEځ4|2!c 0F#hJl bb9w45Ղ.Xd6PLrnh*g'$}dHJ!9~\ O$Mq]'y@RJ)έ&߅g5G.Kr1EL~/RJ$irOs^2?o;;ϮnW>> p[stjIDwno]ҷzu_}n?,̨Cf{s\}h}B3^ͿyYϦ;?<^C- EпypbPR߅6ɼ'"g8_7ߥU '`NvF` ĩZe2_"'JAoqnqrl  NYT Z' j.LjXތvܮThwKg.\yt&"&I8ng42]ןz#d6o|vǖԚpWhsw~W aNZ$F{ix a{UƘH3J p(1DS  3(^;?I28g9 q‰1$s>;yʼnUK,v#I(I$KG/|ldIPg"hdXd`!x JA gx7.ܵ8$}2F1;1J6)6+%5 S2.-ȬM9W'\P""#z4u18c,Ysqҥ`צ sNLy)>.h5Ņ6bPJ'AwcـHϬ= Oxp,6Z O/MOc&\Np 8Kb-Иs v1;OU\Zuz/\zOCwI\0xi]IEO>'}-D,i\C0'bZϨ-wG) MNja_ };{zT:E<9Qitcz.'~N0?,\ ʽӼ.{wBZCΟUca >5REevԥPǮ-6UHqf:-{0 ؠS̿jZ!ik]!̆&űH+*j֒CDUm a3zD-qqi DJZD] fX2&f"{:wi/sFhhqɜQ3'.*af,-'nZpWhx/NF»I<0]DWj:)2rA㏢- Yc&%0r߂RkAQ̡- Ii=ZޛIr\㎼שׁ@8((Pĕvvd6_;1he2ΚvfHZI $h4꫎;#*#="2QGU=5 0 ~ac[.Lv7(ܮl!H&M(yQ";A+ $<{3EHͦԀob8Τu[` 0fC٬ % @6%+B̀{&_d6is̆CfLP̢.%|LHHiPkj'X59ܕyo-0d`NO6=Ҥ(zεXYB^f#AɏؕYsNKKEWf쬠:Kˉ@?_%htXJR#i ˲RAnW["{v>Rd2LXSg;Cj6&G&of[΋>zZGå}g珿ㅒj4][}RLQ P(f庲ov@f A?:܄N;(RIɉ3 {o1wJ'R/Z_^ wVk֍{Հn׎M8ZܬO̕qz<*n5珸jC/1g\j?NzaqVw'\o\/ ^neX'o~Fd>Z~^ խiG/菙{SS|.tb%)/_K]Y,r}iz9G٬ˊ, UoH/cfwgfw>%;6ڽo4hlIRT:vZ\"ժARu^w2!/8Sw7?ZHdƝ]~"Od 5!p}j uF#o4)v6M_}~u_nSW^b$ q?8k[OuS@)"դ 'Ikώ:>Z?xJ.[$/{co7 ŭT !JF/?J_4n~a(޿;ZL~O\N!exO؂D:9,  bi0{ͳ3˷KW+aAxDsYn|Lq vn6zu޹UU+9`iyUgZ^O "д2۬@MEe?|mS܅~bx*uϞt}Tynyny{~e B? ?( j>Zҏ.)+HAQzV߻](Dw?xhwN;\Ibt^5SyH .wVU~|Χ=daQcw}̋V WB 4msJeX h M5jYXX0 r[J< >lZ@BBGdEkU pOG!-VeM;0_kiNzL[p/T$}N$Y)eT' C6MMvGip:Z2ʖF[5czؿ/rVRpqzKҞ8q9IgZS zdq2NDݑŪ̱T$MRo*NxF[ehh29$bLdn3YFNNGr]:RMx!`1"]`$qd>cnh=}7ur]*b̦Яpx'?ߵo8z<*Z SX߬:/,ͭ|^OӿDyHsl8]`o2& $~,Ng| ;'ML_Lol[Qc8sgSS?f zkDnІ2*3Srx c @]IY, $΄&W-9[uOHABvԨ_,z~5?@>dw$#RI2GȘ":KFH2Lwjj(32#f@a gb]&i`d[A;<%l>lQL0-̑^CX)aa 6{ s`?tqY͚00^i 4l]6Ce0l1QnPb !AM=`lwA]y507X_|wAd42eev6ouΛY&Ꚋt#ۃ"#dWL<e|WHR6== K?ܨl6<*쌎gˉDYKO,,1]\y?/Ee#oI4]VKeEeziiffb}Ū! O{t滬 ]7ntTk6;cg|F4fˋ~ѱb=6b! z77S8Y|^kc#968!0T-9+j'8a|8P7, ǎMxl},[]v^'Pʝ\6vw~\ߺ~N&7jF2Yd~W_y${t4МBYd!`+yZy ] kǎMST*FFBC28(sȄ,ƬkEz6l.a $Ii:##JQ(T~Xd~~zeeG(*ϳswf&6=="I$Q(8Y8l\C/푌oy}>EvԨ_}(|:365{XdkB&,5l P;`pJHI %0-ba{;=99La˲.B|0⤱3pր!ay&LfH L؃kL,B02 Iܓ5& C(" HonEn^Gbaq,6džJLdy2&0#}Hŀߟ,B˲ҍd[,jssAX h!|W.VlA#2T4M-/{w^o '&:ZQ*#$;;⪪V mb8 msg唰؆?.O$rds*U(jG^]ygzduo6X\j6E@nnnlqq{k+珬Ee魭n < k_LVk..n?̼!Cs8wz|WfKn{'aבaHU_4X "D`"\ciGAicKCEJ]ze# gNGfY!J4UXVhYTUeExKlaX,3gw-}@g!<#;%ӆf0?;|MP; E14Ͱl/8+>.|ava!p.t]feEeYch:,4壅^!@,c#GeUUƃ> 31_mZLN0EeJ-hBŋO>%>`ГJmil,p>K?AJD}t:MS#fS RgO$f08Y9%,,!fO3:b fQMC>& J $4IB.]8F߯_0wj&SVÉDnmmp#,E|>_Y[K$9:/u%F҉Vl⮗&EaCw-(Lk"FO#+2+}]D62I B[ VtǏONܹj:~|" b-Ѱ,sscsw7/[C4M=ıthW$|iMBv]TlVZ2Užl3?w<. |Wk ( %yZ tdcl؁[m:w &̚S)Hmjg2.A0Vz{(=w!ؔ~<\VbN 0v=Kf7Tw&w00oJ=0[ww=HV";jԯOq@v9|DX;vl|uu7LO7L42( c\(TXTdgENF0^㸾d:]|SFb6[.Ґ|WX{ck_3Sߣ+˕C!o*U$鱱Kå'&77Z ^|KQNGv:ٔD"]F%а:1~heY}p& ]@=LOj6&Gљx6TtDՃ۱-/("&LRoO2ԓ}ub楷n-eYA0iEC$ϘkqOO-R~hf `{P-. r`'PYaZ>`c!/:t@.,dDjEg0RFad+zL0ޚD& Tkl,rp0vOphNQèW%fgGIZY4FG##et{+Y]=g}O1ߵ=wno/xv t66Gu~κ\b4y67SѨVVsϳDnl,bāfu" A.k^@&n,!3Z&jub ܑť O;ez (Ǩ[Ha腅ggVWwwwѣcTD6e2[[xwf!EʃMUy/*y맓dh@zy&~$ .z|{asX wO& F gxKΑK_Vܘ#n/a/kF _|"R7D=;`h1u1dZ& "KDdys|݊|dwu[IRA͘=Y#󩖮 3X5fhF݂?C].l"{wfnZ=?~#i߳ v-U0ԉI׿? Udh=%3ya_CO {s:w}jwhEҭLJ3>$U O'ϋyM?&.S莀0Z03ɴ~.W. B]z3Ϟ٬5Z4r].й9w >"m_n4ZK:'\~ni,Vyzf+OeI਎BFz޼^<}s1B'^0v2fn'ȶlZn)_, Q+uEw>l\lYP&? G=>Zѓ->|&%v#}y'3;|R/>yj/^`߸^ p!HV{Pѣz`l[QWOMƜ؆`9еKXX(]Zm* Rp!ndhzbUy~l7_gwn;zKjKNbr 4ZO4߼^].)wyU+'۪K5 _WmuTM;,$ ~X'÷k6jA );?M˭cΏ+/}>J52 9`#,c~]9wݩ7t|WG~ȈxtquϞ[԰s3 m芁WQOh udm(Yhx< ܄-KB{O]z XslFnVN:͐cӧ| k_~*)Ia!ntĐ+I0ϴ#>NQq|୍ڗ?ԕh[a'ȶu!?~CzNLno:s1Ū Aܘ%1/?8b7MyfrGN&QG( ThG%E!)dĤ+\"KO"99t^ew':]>r֩Gd'24;j'Kǁpc+QoӔ1_lIq?sm AOv_t;oJb־Q d2etޖɚK .xАc!4rY0G#2vR25h&cYmlbΡ9}I>xaL;,//u:wygdd\.OMMy< `c4yEQB4MKxxZN&X, h4wnléklyyyll,J@XOf\V~>-vu@ K(ҩ{]X\ܹ\gf(|X,L&~,pRH$~ <˲Ej5A0ƕJ%Z- ,4L&5MbO<ĝ;wΞ=[,^/I!eFHD(qV(VVa8Av*ű,iMQn5gk5z~jMcpUE.MG'lѣ|~hhpeH$)f4Mx`$2d@\ǓdBPP|@EqO&>rH,3UL&3>>bd_w w1@Q(kϲܤ(&,9rn_|T*]pP(3 aenlO$GG:[oKKDBTOCKKXZǎ!I$:wFllNp㝉 ac#Y*NO>t:(bݻJ{9v\oٳg t ֖.=k׮=cc0fjyy9 BVڵk>,Z655EQ[m߭]f^A@gOC/˞Dz]}$Irsܕ+WVU(BP$H$yo4jn޼t:WWWr677s\vcN_uVU4($v3G  Νs~Q^Zj=*Z^3P(z<uWԔ##|"!@0ّ$ 677CЭ[`yyZ Z-HlooͭZ ~1i {\.'c=fL7'OLӊ[~7ߌFz"OO?u:[I'C_I}ufPrgt(2ap8 T*Q٬a;%`+^/++Q 06Ƌ"-T  q3?p8(3q;9/-5[۝lVYUH-.e^ b>xvX:35M].CP:gYm}tzW˲S ) L J,03ݽ:  E\0Z-ZL(LQPҁhЧNkzh4L&Ƿ;JRr\,ժc4jHA;~&JNL B3F8:j9r0# ;9-w$"rT/..~+_Y^^zv{fff}}n={vggl VE;wfffRTPOU0+ 4b811 KnZ-V0QT77 qXUAQPC KC&E\y-Qyu17f@@jϧ5MVj<ϝ;w`ssjEQ^V Fn<:x\U^xacctJK? \Z.0taaݻ c=fy=wnsЊ5ZjE_P [c y]%`/BN^x< 㼰lEQ,Vj{4u _sHӴx\GbMs}zʉbgb^$JM Ѡv;')Ti&,hTn<:.812I%+Vp\@|x\H$ƪ~?EQ~]7l6 Zf;(=+ˁ@ L^x((Dh4TFЫ)@I$$[ʉi֜NZ\14eeZMENGrY'%Il\jzKR8IgoÆ-ND"4-ݼJ]w:g,N*u}h~0W(9}|_s2yMW0K @xI--mz4gWO%YoKt߾p^T dԩST* ]v:ujkk+鱱o߾===}ҥӧO4G x< j5դq&ԩS}ޞtciih4 aЅ Mj'&q꣣PULvNzc=5%8+|{ !b._~K(,..nooߟ4Mᅅ4V꫿[E ҥw''Olmm`0=??Yp-׫ol"؊_?7nrvn\ŋW^}CǖdcwI}^I6R},r= "(;e[~rY˗/1}Gio}7o[nB!/_\.:N,?-bYeFqI=1N8###NgjjJ?bY\z{mH~B%N'GGtZ*r`tl,J'OR5MJݻG +++@@x L: lrItҥ'O.//'۷o_fo߾b1v=22qΝJ2<<|ƍr|].r*2,#?,+ͨ0{3>"$A̸,gldAwo%oK/y晵h4xzNܹsieّӧO_t)}:HLOO|_~~\.OdY… ،_r4|@?:<'nN:]GI(Vbt(j  HQHT*`PN$mIbC\@g }w:dgҧ ].$O_ES .WݖȼH_E&?0:6|Epڵg6˗/{drww7ϟ8qt~nFeY B,V522$)VKF![i6]>cE٤dtIp"[,OrV0lҊT4!E|].٤A)Na0D"`0/vXvWWWܹp8x8p;H$zzNyaaAqnk611q5M8wvv)p}޽x<1^\\TEp8\(Eؐ$Ibiiɘ2W''2Vp![TRceEƈܯo!i֛ S=e/z}XWqOEqttT?h=55G|333U355FWWW(X,VVO>-r0`'ieh%_D$__ipաáv<U?3<9%IpX*=+. Nv0izdd^\fj(`0.~nРZ-IQynIL K^+d273'U*m8a<؇`A[`NñE_刦_1([9sj}V/^Ny^O^>"z(kn; ?駟VE'&&H&]__㒄'^mMO {{I sx ^[k"57'V*Tj"9q‘RoQ1F;:,huu옃Q8N\Rs8(YZj;\]mQ d{{̙3>,ܻw/?,ˮlnnNLL_|8wuj?~< gϞszR?l@zcAollsKK%N' Q D$H<ib(вGi/Ap(f|CG?#Z:_ ku htrrR.X,+;$IO=˗www=o|_?/.///ɥB!xv[J-TIٗ_.(ΝsRF{vV(RIv:ZMn q~?y{$9uNv>!LkmB!)L&/^x#Hf23d˗d2T*˥_!777B ҁ0 CӴ>B_eZF[n=/_^___5á=eQN:@ξ}cQ;F>vІ٘{]tk{{'T*<Ϗ9sΝ;'On󭭭:P(O~_~_ gϞ}w;vs}}}rr͛F@`ht<?w\:=s֖w^( ;;;ƽ'H>"t:;V q\. ;r"Ϝ9s-iZS9ri'NSIN"Ky]i;1vCŀq!looONN?v!ds2f**E!A7rѝF114>=Z, =8R8i vA#Ϗ<@`fPVAJ?9ߵ>,\dXW}H{F3 B?#߻{Sy^$-jsAPTMgF^\.^X@DQeҞMkHVSwiC4 *`PUՅt:=77gkJ;w6778 6H$j[}>_^A?rld}*:08 D087fHD*XYFǎ)wz4Ml@jx=A[پ\fΝ+mn{$Rޞ'~~*<ϧǏSE8Barr";(*7onLOOP>Ezy^n`gEfۙlbYb姙2mH(G?j^YYF^ y~ttΝ;n[̙3lVoDžJrzjuuP(pW(fffBmÛ(jf$)@٬:348m^U hN_IBDv{$hPGRyTbi;kTK_- 3LD"/ׯd2Riff&ꛄV[ddY[[|W^xZMOs z2_fΘJh(4gfm,#[$tNJM .%N \oDHwv+LW!(ʘ ~}U`yjl~$ ǗeBfC{L?QQlQ_}w@JOtA4lAgg[{!(g<~" ]gr^  ai$ VUڵkoƓ'O~fp\.dYܼyF|X ahUTaHS;K%9t 2IKT\NN$ yyni Aw\NBͦЭit:ie*:>>bnFVz(ͦ7[ͅ/Qahm܆n,{6 BbM'bb#x@$\a\+e{ ػmK9Q#FEvD gh?\.}UU(J?88XYYA>AHRRivv빱͛7A@ZJ>ub,˚Ml8u5j5=#0 AuŋEH)ˆ NGBQC1tqr"\(C:>}g?;\XpI׮qV\)IR:::V.+͢wNNNX[[+ZA Hf\rxx0LV3337o޴X,.--ݺu룏>^n޽0 rt #A8 (Jdy] BhtqqO?EoujJ-۷nRtzuu`mmΝ;GGGϟ?o4㼂lllȲvvvDQf~?|>j^ꫯ.ǃŭIs&fC"xg,C>(?y`)U!`FL޽hhlPp8E<G#:rq0;;{|| =(FL&CY"(($IKKKFCEd2Fr=|*Zhii&@gWov 4 e٠(xv*۹ܕ7p<;,] Qb N'ŔeP(jFp8ѭ8$z=tg=gd*a0L&ApZd2'''@vD2H\^#VeYAPP.8P0Ѓ6Ry61 w Eﺤ"ʣ(ݝ}ġWedA  t@GG={-àx`cN ڤzq@@z:GN0iH!l E & M%e`8WxLE1s9\uwfЫh `>.ylJxuˈ\΀EYQ$NݦN#4A0x~wbuQ$D7Z-Z01ۭ)%&I)niF A2!;1O ʷǣIPU}n {y3|Qhژiިp= y!rjz"@SUv7'g0:V0c^2$l݄c~Iً*)`<04`0b< Cߚć^`ydY`"Ϟ=-J9??svZVr@?NFnMWy x\q:+?iχnmm7O:z tn ={655U.嵵5]_xH$lXT*X?A\yP(Htzz( ˲X0~lqJhwޘ+\n0fR.1dw^%lLh{#+`pOhRA 8^ ^?4hWvсť%˅9*j& ~ LӔe9핕d2v[c4t:'#XV+Y5tR jg˥Ӵɲ׫:+gݺۭzXL:>vȍr$rɨ*\Z)42\.MhjJ,OEQRTJ$Nb1 <|rݵZ 9f$voyyrE=uV5;; }>MөT l<ʲ^r99;;+B$AD3 _^o qQ~<dRA]|0}>Bp$I14Y:: 3@<!oC0هgg Ta|WW=Pi/IA\foT |=Z^v ~ۻ(Q|UvO r}꺎uݺo{yOH5сBaw 1!BTZFdt$i&Aju=~м2ǔK]7 ì՞%oud)`}tX6d5U#8(gH9&_[@vቴJ϶EQ|sssz z ޽{7ۿqnzt4/8褺@T*q/\as9#n0^8=BAv W˩x}떻PIFt%ūW9~v @|r}*xQٌBannP(,//?}G?Q4}YPXNӅB?1Y7G~'оǧ~[[[,|[*x'eٵ[nq>bxFz>~ mkƲ,ph\ӿ129Lz`aR>S"Ou:P/,[[[nݲz0і5mڅ &8@PU`+?h1c^ >H۝I2OEr??n7 H9AE^qaD˗T*JyO㸹9QܹH$(_}ix4mqq4m??Qh&øH*- OuIוNVy., VDU?PA-hFʲu BH*4\83Ww!M^/GQ,Ke'4TUSQ>_~FMN0fW^Rx 4M* ^AB>4MN$jKNQt0B`&z!jt:}rr 0+R{$XX*9hڌ]$i:<;c ݦD\YQ^J k (܏et(rN4Y֨V)^zK9<, ?h?ZE:4VŎ|M"+U*a&(`vvֺ`7^kÀ{i2 N%IB,"A(9iEi2X]`PlBfcahF|2l8a Rk"f @(02k/V>OevX(*99F\}/ $I.,,looJT*{\\\T*d&-R0 @X8NԛH( czim*Ѩ(DK9 :,kJ0.ȏ!fBxvv>} BzAe}j0 Bh@J%43ij5-"0nZ"ߧb@ Yu4x2zӧ9NI2u>CVB0==dwl-ID4Xϛ}^DT[Ra ggiNruKT* ϓ&Iaê<"v^wzz:6`0H$B#.kff)DMezL&p8,2 Aiq\ZEW---΢jy21q">ᑉՀY%) #9u\Y$I$Ir].$?U$ Iv-{R"H8F,?<#󯿍Ͳ.o.[zq.tZm7vW( i_1L$@QF,&` ւ́4̇ch%ZWH&\]H\n[I(QT,kW6'cٜg  & 8m-I#-L2Xƛaà3OMC?F[o{]{ T|w4!Σc+3.Lbp  qe8= u(NJ ><m7GOJcA v9m JdQ-C0 0@յZՀJjkyE4PU]Uu0EuC5T4on&Vӄʲj$4n t@+4u__ʆQ h<a꺡芢j(atEѰMU=OږEMӱڻ29أ9:8p> q0: - X1ž8d0*v禒Q!>Y6ei0Szx:0 4UUMH}v C&ʕ+ӊRǏRډD++N(j*)kX`f&vxxZw4M<÷77ׯg^8 I"=xz_l[Pmaf&͞ pk(\2]w*}u z$I1 vjA(_b?}w߿L>|ӟ!͹\ZxAe5DQ$jxTj 2SHxͥnW>Vxדߗ8yzXj7ṋݒR<:9)ݜ$SqhpЭV%Uơ|_xE&ys!=8n7˒${<\սre{M^׍Hok7 ` y z<4AvD"UZKK3''n֭ki@}n_:0T'd2Fo'2 bZ{AD05Mw:~_-b-gSSF_ZEUVwMg$EQ播Vu5#J)F.TjA@7bjk( RBsɡW<_ Cfř4@ljňxx28uqTEUєUa`8u`ˆŗaM(Xc 6@-#mYV!:ꃛLA$e\UU I7]HeRʲ0;?TA,+ v!YQTH PaA)*Шaf7>:Eg?kdq!>#.0MS˹;"]Ri(ϟ)Z?~߂3b*8`i2[8|ytbw`3mMy%#'QmB3DFhAӁ~Dik0̅)ϿtOv[hh4nw??X^N+lV/_EqcEU-bdhFH[-ak( C+WfN tʲi:MZ.&@4}YVi4 x4A6[B39wvNVV2T`iF__/3 NǶzkYUU(\(ԐC^V'?;{oe۶%Dd+hӔʕ0cTvvrssB,Jk h6y@$}`4IDa0x  Jkj*|9 H"D(w3~{f&JELEߗsVkn0:IT*N‡% $Iv:d`L"| @&8|V }\6[(o^XU*D"47>t:iMhz]h r%vF("F"BUf<ٝ-/!4M3c39ش[[A m qҘ ɪ:cs$@|0%<\cB]ȱQ7W)&=b@%].""viFH`Vo 7ǹ~"I ptz|g`Ė 3]p]VՖA5GY5NwAK0Z 9.kA<?$4HAL##֒$nİ5^8Ps}v |\'Ov}>w-i*,h;KU z+֋H][ۏF''@{tT>8(RnW<:* gdN=Jj'{=)-u:IBvϏf..dY{ddEbƲzѦ,kPy2FOq}/4u=R#\ݪTPDzssɥGݾi/pǃn!*Evs߻wdH4uB2ƛOL'/[c.]D|H Dh shc,13OCK搩mq4 50 дژ+A"9xZ}zTsSpBxlp0+Fo6`гlnftfAl72n7!IѨrfwo޼9)2AKKӨ) ǃsw:D(rX֎ǃ pt:*F(;.Q+R;,+ЏC5sy+یㆬA|d2}#ɐ&0Pưg?YfJ:ԅqyrK(c 2KZ%IPwI#\@yEIt7^+HJ3C~2OOϦRH'a9b;_OOkTݹ߅߅E1B endstream endobj 186 0 obj << /Type /Annot /Subtype /Link /A 187 0 R /Border [0 0 0] /H /I /Rect [ 233.2425 338.1166 244.0845 348.0372 ] >> endobj 187 0 obj << /Type /Action >> endobj 188 0 obj << /Type /Annot /Subtype /Link /A 189 0 R /Border [0 0 0] /H /I /Rect [ 244.0845 338.1166 254.9265 348.0372 ] >> endobj 189 0 obj << /Type /Action >> endobj 190 0 obj << /Type /Annot /Subtype /Link /A 191 0 R /Border [0 0 0] /H /I /Rect [ 254.9265 338.1166 271.1895 348.0372 ] >> endobj 191 0 obj << /Type /Action >> endobj 192 0 obj << /Type /Annot /Subtype /Link /A 193 0 R /Border [0 0 0] /H /I /Rect [ 271.1895 338.1166 287.4525 348.0372 ] >> endobj 193 0 obj << /Type /Action >> endobj 194 0 obj << /Type /Annot /Subtype /Link /A 195 0 R /Border [0 0 0] /H /I /Rect [ 287.4525 338.1166 303.7155 348.0372 ] >> endobj 195 0 obj << /Type /Action >> endobj 196 0 obj << /Type /Annot /Subtype /Link /A 197 0 R /Border [0 0 0] /H /I /Rect [ 303.7155 338.1166 319.9785 348.0372 ] >> endobj 197 0 obj << /Type /Action >> endobj 198 0 obj << /Type /Annot /Subtype /Link /A 199 0 R /Border [0 0 0] /H /I /Rect [ 319.9785 338.1166 336.2415 348.0372 ] >> endobj 199 0 obj << /Type /Action >> endobj 200 0 obj << /Type /Annot /Subtype /Link /A 201 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 499.0358 237.0000 724.0358 ] >> endobj 201 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/09/136k1.png) >> endobj 202 0 obj << /Type /XObject /Subtype /Image /Width 269 /Height 300 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 269 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 554>> stream x1 0 =ll ּFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnF]C endstream endobj 203 0 obj << /Type /XObject /Subtype /Image /Width 269 /Height 300 /SMask 202 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 269 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 79640>> stream xgu zNUu9͝ r"@)ʒ%ɲaע-{VrxWZ[dKkZVXI%YH `fЩ}oߞ;~~?\7ӷԩϩ;BD74" t q~h^v I} Aw2o|{kv7t nAg!@I 'ZgZ Ǽk]eC^ /6ՅɆ b>;!kY3Ej$ P˲jumyX`"Mz\_jOwې%䫁ڐgwչ~i/ykjmCv:AeCi= ïKL_rnv=Y+Abk _5ěbw{ߟ} >8>{W|ǿ ?c_|Чܟ-?=oRL@;O}>~{ګ n.__>|=/~{/BDOxwnr>X5}s+?G_~_xB^?ȗo?w[O.2^k끇m(IWH'5\ ]݆4y%ЈH bR/eSuԡ]m*??ve/~Yihg&TS>3ߖG>yc/]7=co~u=s.ێղ'~]#}}kmϖk͏B?q'#{GώϽ G'm3s3s"8~fs>uS~O~K3K9Po,]}S_}MVw?{MN]᜽7E+f;>79yWuPoƧ~ݸΛ'?ǿ~@Юc<Oo/k~'k7g $WG^GO}_y^kZu q+/疯^9$ C[ߟahHV߹wzO?o,u߷cOƩ_?3}/~kx뾷Gzs}"4/?z|)xb?◾/^?^^^(~s=܅wox>-%+~\/B壟x|f{* lv`M~|l >msRs.~꫏}SvlJ"ũſ#3˷ܟ2pԏ&f?^{'돽o'ѫ툚='j婓oڣ'Z{/=Z?mo|)]?>g<)OG/M-"z|\=._o>^m` wYWx5_J`n{wZ#"\?KKN_2ݑ]7z<ܛI;8Go?|DG9c=JWuXE/< me2=;-'`]=#=6)h.Y _-D pnC46ի}\?|խGjxn _ \ȯر鍷^75o?y}YyQ]ooz-Jr~xM/xݶ86Z}gNO_?<'/̯oٿ[N?őܾmϟ2vey@OM~v0>wQsϖ}M]+DO: c}k\)y^G_~pR֭ݸ•]$cûG鷿O.o=md wf|ԥmpeqd w+yW9xpN\TD+z3G ]v ?}jo޴ɾ\w̯a=o"'0Źҿ=SKWADڵűl۔?uiv;_w3G^x-1+5o;23ocK-w#/^ڿ}uۇ 릟?n`6^vz}/|',L/a}s7\† bC<q@T1J7~kp}{!p?НWrq | Dp~#_;~m]=Ǫu7?\Pa#Ֆ_X:-o \vF",GXLѓO~if7> O}@H_:"(/kp0oBl=v;qGߍv0;nRB xxFD;j@Nd}6A[Ba{Coͯ:Qx]]SBxl}B !mG8L$Z ģ+0CkF`ˮٻxf`c.D@x  \\BPjϟbO)$B˂sPhM6=  5gmCEg,,,AP^]e`"4i %= @&QmYlQ^D$%$F8ʕʊ0gX-.~BAWW6;$CX@[&,C6ك-PyAk`/6jz%m=0>m m<m+آg-ː"fKKNC6.mc,&W*P T =)yشJ%ܺN;@"8v FF`fi ǁ!abP|ls9Cׅtb1ںX])tHielJpq\/_|*fP#G 텩)ؼu@DMn,j8="siPFerB<ժز;\yemf&rMDB>l:~p NLF"RZZ2deM⢑NQ0qgg׼fնٕ+UsZ\4.TyC[g!@K!ҙz܇7t儷w;n3 m $j +|GF9@$!ѠsѶM,s\[]d+A4mŠT"@L j@ss@(&m  5pd{- V,?5 %.tv<9vmHF"BlDzH$׊D$@nj1wW.^`,Z<1J3!0Fy?d BU:@RD/mI5NnX^[j,06a A7wpo{ щh|пÕuY\,g7"ǚ"4 y~˥Lxc{Y }}%t-sC9=DdOt^jҥe?B~aח jN~5|W3c3nC]^zvl$3:_ ݮ5݈ 8lPjbX{}%a-U;Ǯ+,0$HXE a:tA/OdF$kGFr :sKOVJc njgؗ0 W"t$f[++ZSn Rb& pƗjח1 &Wke/cR9jIEJѾtҜ4&#㦦 HGJ,lvKFǥ}h|>עХr}v mnv 5t^Uɴ"T*F32&'I\n֛XmE4&]L f USGd \%Г|KRgr3-?Pf}O)OZwܺ#{&"ufRn;Hr/. DRҒETTIFz bU"gs(}ª}01Vs|DD"Ű3S";$Ɨju+֝ބSڑ .,TTBlY|g|k.8X99r-O͔V*mM{frudEMz?66sQ!@q-oM;A"#aw~cܡ gp=ͺ:׆I|{or2??zn<ܻn%&#ZO4mθҡ-٦+͙.X<*6db3SvSjj=yie7SS+LHo/iB\*-5w"yX)3ZTb=#=z~(iDua>M I"خ$5]yllf{Smz66gc Ox֔bCK j9l\ŌY9SHp5וd{uJũYޡaMp1sޟaN6>'͘ : ǝ-XSHڀ}]lWj e ;v͗HRZC陿䗶mnI$ʮWϚOׁǏ|kј|=w׎5^:=x-lLD-/LTGݷuK&%@۲*".-[t.X왭Omnz `n Ӑ+V"HivgyR*RlpM70m;z=7˫5'f\Ƌu熑\`@PjNEuᑊxDdrPɹٹҡ99/T.J¶jEႳΑt:F[kwR{rlWS6d}G}Bt+A ?.,nٙUjjQ:'5Ǎ$M <7:Ұ]HMԕãT_ԑ#"nC`щ 3Qqm;v=yaRdO8쮻cǎi~Y\\x<^(3OR޽ԩS{9wΝ;=ϫjx|zzz>&_җ!O>uԛ&0McJH$JnϧRbrl&v?Ng MIl]j.XуY uF73ĘozRg%J: "s@JIEC .tj={t_ZZzki?77Ɓ:泰Dvn"""3o&rI=5Ǜ[r[LLә9,[6?HoGjqL42d@)%(c0]bD8_6//׷qk":gp\]~Q1T\E}q _ A*549B=ٙlDEt0wc*::8]̸=r!Í&JE*?C( z %!٬NܵQ" dlٔ:,FV^ƻ=F=JIOJ55]:> hj\yxgLI-gD5˵|R4M6ktu4V۷oO$X,T\.NQd2W\ᜧR|>ﺮyLjse2D"^hb|>ZTJUu7'_=p@6go9%Il1u| "jZtGrwb``j("ڞ 9",լs兢k!qJH"JcuRD Pz$RRs83WԽpwN4]3lEyd\Š :{y; j k˖4K)q]*4\F{cKeZwe- 97lM1Y5Y';{93 "Qӱf}Oj}lo#cfJISۖOty4 qM]O*h|XأhO# RӟړPrʥ2[UUn3Gu5"zgn單B! ڽwU[l1R)$.F9'My*4DD b,\$j (TL+3È`p!SՉX>oPlsJOT<RD" U* pzrÖ?8#2D@/77gb-0DEI ilTttؘ)5JuΤlxu%ŋsMShuǾ|O_o;R}b]YnV3;r%7KZn?|vw?f{VX*+]c::Nqeee)S{J!c FFraq.ZeGE4nh! IR9KuqM&RU?Ds7w9D"13~mK MG,Kmi #/oI>[f_/Z, 5͓ (N_G@ۓn텕RFfXߒ4p2Q 9 YCCr&'cjw*s"bhecF'.-낹j:qH{jÈJulA63ʗgJqbilT qlY}>b&I % 6>>Å0Mcii)+z}v "a҉biƒvD _>i{>J Wa( 4hۍV7hf=SkDhj 1-!Vb9[RƶN# $"NnЉUJ1D:E'uO8ߛ ۬S/9𙇦3q̕o{{O/,++ \>Op,<:m[6Zr_P S؎tI%l[ sDE10ta qD`&O0DDWўʘtۓ[] mrZjMZӻu{|)nb٥td{_</WۆܗVR-74ގ-4_;Ѕ@o\OB2\ @OR_8͇ Jŵ[w䒆Vh.ghٶ2Z_nݞy(GH,L,=I 8#"TJ} &7v+/ڿmtS.kssΜƑ2ihkrF$Ct%Ktiys߫fjqCRyʳݦbd HEj}Λ04Mu59kz^D<1NiM+{ʫ^<1Wnnprm>\=S^PD+r9FDiqk P& lGXlTxҳmGhBp.=]zqmwl729c8)jXnDզl=~ͥḚR)Ch†#`[+ZT%l+kLgm4[VT ;4_]߭lߗԋd*ޞfyuǭ^:rv"8MćX\Z<϶z:}z.LR3@"g mm^BJ% H"E#* 30wy/i޸g<>^r\@/j[V zWK:%De g LdTVrRMTvcO jɗ&VP*%1`a@vpwطvLZNwĭk@ (1cPs榤sۑզ,V/,}\8U 8AOt)\?4@OmsHZM.4loBR1s|ߐͦپ~OE  Y6R ɯnݒcu+fPf >\5]0@ZDLD!:NRpnL\/\Xh1$%d#&M#)ny Z#k/ߵ/GA+ĥVf"C\vm󛇇'&jփkR1|Ho""LǍRΤ X.I 1/IvM#C[/lת "蜻ù 0H0H&]St< Z4WhVp@HQl6#9 Pr53 b)bKH"Ig_.TD\(m5l(:J ]`|Tl*]J^~p\A*:נּ4<(c2&Iܰ1̖"l=9ןXqd8%BIDyu9cr`̯`Ab/BVBP/՚d<%( +)}sNDT'O>̳۶o$l"e.P4 Ct'dD(>AJl )Q\CW5qVw\3'uR&zRz4,%P:\Kq]}V}F_eu~'tg._rvdfS1LhooEk7қ:y"8{/˗ ],..+ri`ЍJ<Z)W*9!2hjGj|7DD y{*|NRK˶ "ZlO){؞DDTP]SEgJ.8Vg{--C" trtiz ycs _XL.1jp#4+loNWw8vi?yefD';3[NksG;W[[aJUm}CQ zRga A˓o}[{ .FQ!B. F { dC=}+H6*n?0uy}q]1X5g߽g`bjMwBcow%}^q3ss@?5h_%Tyf+Bl//ڒi j`7c M[]Y1"-~To4-6/ES'oLY49jH1}=TL053BTF)sragCI & = J5Juypb xJ)@|:+U f|'!) Ϫ89< תw5Y12Bl~B7Tnz7f[)[CUry|kro"ixѾ޾X,fǙ_Qc0QMnUh;qrؔR5]g}q3 h< 덾xۮc ~q&w4}[z omGGU˥vvqScZ>2I \-׌h4u<“J.0=:0Y˅>jS <4uOc,GaHKsDD9hmWl@{%^Q}ۛ;JR OMlּU |d0[~Hֲ& M|ז-F$2W&J`|4#ϗDj8ܨ޶ Jn@*7*vj#y0Ж o9޻/֫WՁbSLI4cр H c 100C9ʖ@%RbjS\K7w}dK$uTwO{ַ^^/dxʶ$tddfRTDJ MQTBH/`,)-:XnMG[ z>PNk{\6d%nZ/, UziʍDꩆ{4g'U }/$%C,bRȁ1+"P!x\qy9)Wsٹ^'%MOG* u7fb;c\68KW+;F͚Ld,M**f<ӧ\8ff^r>3J(9a+`raƂkČqv""7,-/tBTEDD+84J2Md^ e\;>\XڞBȧ6*7,IhZ}goOf|9Kc|N&Kx)A$ ̄QdS@d+IwR2| lۆGqւ9/lE$tGlYIRC./ƂלZ/hU kTc1HyтX\Z/uNѷHL@P̏-2X-L@ɘ974E񂊩sbiTBN!C%v"!x4ꎂDW_xJvވ3qƭ'ݣBQrƍ_zy.7MF $RH *@&cjVt XrKD %AaZ817nZ˽^'cS)fAmJSo08}~qahfs49ޚP%dʡ/*c,SYc0 iؚ8)T,gRBM)g,bH( 4)xP"fUJJFtv(MfZpt# Ѩ"lChM&Eo,W7 c3q =`0XZZ FԛMiw:]ma̎6?' X >vsgBAX4tЬ7b u!ryi EN8&~|n mhkW y{I2;wdj_)Dx>yfR7EJ@ZR&;IoзLSu Cx2FDJR6\YIK$c@̢ZcIsaw^R7}Ec8]%Bf>Yw=I@E|W*C)1o+? !)n'\>c1gJ EDC5a_2S]$)6\=5K ޛERQIox'Z9ٵ#꺪ś1~]STJxV"AeDԏ]mvJvܹ^xʪeZmAPV=iBHN/1aZ鱕\(SuDaت\f Z.B/&H)Ar)]ǍZ*CVI(Q@MjsTo.:s./7i f~NҩMxf')IJ?}~ް3 8Ek@m| v I]ɧ^p=WH:Bi]kPJAEm(DsF ĜC 2,Ul56ݱUʥR͙(Rhz]'8Bc?F1nWSb2`[BQݸq-//hw:Bi0)Tܽia{0R@-2Mjp\t[KMA峧K8ewÕDSGhd!q4y\sM2tPlBAjF(q cvѭ*13T%vp`z0{qrr8pL.a0/嚡cmJ|WTB.Ǝ]Y<(QR &($ #А1$ !yGjR>~1MSƓ٭^}g (4(9bS;'֙:" .\1Hw P 3 ?? P|gTM;/W*PH!xCO q!?YTkp8ygwܝ*Q]H0)%e8^rwCUE#; Y 2cl4[R1$xA@ewZѭ ۵Y9'0KnY$GcOStTt yWBzRDFG.DSU/4U5V([Y Ec&`v8,H) bտwSw;GRʤ6@ ?J!]#G߅/Ovk USQtP`B0T8-vcƫZ.f3OU+WZ3u 4MZr~Ħ)LD(LJG0ĝ0tޤ(w!lln*z֭x1Ur|֭{( pvJrky(A+1 FnUZ (3EKUYt3#jGA>RY2QvY(eC5z~bEXs-y{i^໎#I,R(ZV櫓=Q5UQm˖BQج6R$P=gRʈ (PTu0P$D*֨ ݸr3]#&D߽-s)p.V |\,sԟhI$@]N1| 9.Ӑ-;oȒB~kn|_$$iٖtJr,b$"UQB"4B<"(s %/G]Y x8>Zp]$\֝ƪJX:%Kv%(~EJg0WC$bdeY2׾8=p0h4`}mmWd> 8\YRn/eK}fjVN`lvtCm֏"P.nfp|\/yL H 1 sER+ƍq'~gYvEgϞYtU)1.*Z"3]׫%8sq\ޅߛB.!@ʚ,?XUFmSʎ֙FPw5p„yƟjÐ>F#~ثuS1bJ%^3 ×_~ W_}KnAx҉+bFF"!A&ERSSPIkMIk^k`2-Av*⚽ϸȬ C% 1d?請16N_ ucVֻS`qBntP89셠P/ G^tM,j ,dUW>yJq>ԥۇ$KD{u-qDR4z>]P,So*+\=yD4`R*u]/8N=y;VRVsz^ۆaH,y LE"))Jg;]qw~wݽ}rA<|;/s\>lWMj@ݿ~Q6?]_oqjgwߕgeQ8V$JIdKf ×_~ٲ0._;s>|ϟ;%Dq B%g}zIq0w'^ ٹKߕM( ۻs}U I Ő 9/'Q:h4TҞtR0E@)>Eq$%0N  c?65X*XS~R*.ZZc/;ù`[mKIfx? " kk9~瓙7z@BY(zhaWU+Wܽ{RVx&'4RG3TWޟM-8#\(4$\1T &<ԩ[; 3+k1%;H.M0 Te4WWjgOojd9riI3L1i@ֲ'Mxf[+z*z$ ԤFjR䓗l:yrkmmΟoזAH@ØIB$P@y49hhb.% ~h6 XԼŘSwth^r]Ey`꘦0LurGF&JZ&KI(ϝXEԸ7 b뭊Z6qqȋX֒'{J|TqST%tf{XE :ͭsۭ~j2!ݩA7f\,?ߕͲDS]DI/FqpT jQqPA4 _Z^Ha~cR X 5廀E]FE!a6VN'QT!4'v1'ԏvc7.E z!X+A*J0-✀4\#DtGUXK^ ì:|c2ZCHgb&2wa`\(+8:P<^nB&3gr0 RK~.u]Z#oR8^|޻w}cc6A˓$0J҅sΟ>ycp38!w}: ,/{B.ց)1dnkyl8 b?䎡\/<,ްXyf(뽀 cW? @)8 X4!d>h|@]AN}GN(jj5bq_)$aȤ!J.FԀia8OwbKD~p4*`E1d%s=qH9JܹfRJgW*0hR26KQD{I6`h<;0}wWuKr 4kS.wk :Wj֝;x㳟yK>ƛo>O'SB)0B tC+^۶߅x__ַo~3 C˲(%np+/_?Kg/\P !6֝Y2^KY;G:=Ɠe*b)%)GJ.|)d&K28>)KspFD=)'T2Hv”K}KE 8AU"Jx,Z4 (HaETIJb I)o~n/${;cLyVNV$R?rڝ~ɝL3PCiLh%O'1cʴE9`Zk LVɬf1Nݝd7z0bK6+յJ'Tu8A8WW[gf٩ӧ˥R-H)Y¯=r}̙3'Ozil۾sn Wr?Sh8wٍ͉ۣ 5RTjB UR꺁Rb${;f\21.v!TX}.sc#rWR?Ʒs)CUg"9Ʌ) iŝ[lW)X<4 .T4 O&O@X#Z.w.oMnYĆ^ҕç79L/hO9qUJedN|Rla3!A>܅FG%Bs N, 8pBJ^as] BXT͚}>L i--!7JJTH!Ga) :JA^/Wpق 5jtX2jB`4\,%P Aa,B$Śz q<ƞ[[>gi'e˶yJ̢\4Lz(*HGy2_K鵅 g $SB ]i $ʔwe;Tsz+--4pq=V`o^=?*7-E)뗯 C7{IB.tl6RD}1ygNt_2 76f>7UAE˙W Gh $~U b4b!-zKJaTV|qDym;;;B(Wy0<<lcPJ9٦\oi/?ڋ6~{ғW]N, UH|EA6 Cٗ\srPns_ y J)ݷNx>gK{o2院(yaa"͆s|f̦hSn%(Z4J5wۛFr0s)1ĵ{yEUe"W f_O*RJPTD !dOw-fb\4<0)%;jT;rѴM@ .4r8}th~#-.Q훷%2d\@uj8UUz3{;+͕d+yV_Og@T:fxJN6~ӟFDBh:!/( E)J@h{SϷ ÕmJ߻;}'^}啓ۿϋWnMNY|a6 "95hN͒YRU1j26pP2%n`1346tڬ6Ճ.}=g+%"z}uލl&g30U/]OK0QxTRLsx!ΒXT=3@DTlD:@n3m<r2M]iܛJa}z(2qdð?O/;Iҝ(?6L U-?.I;;Cja5ݱ|-NB>vǗ2dΨK.9/@ 9\@BcPa1w)"=m*7oT\HZ$8RJoܸ麮i}۶/=wfo?UjΝTCO<sL0UZ̒])U]vg{AI8V6Ɣ? E!v b!$+uฎ'CdfZ}pOyrg_3.ڛw6Oљy ѨT3RMkq+Ju*7v{}۶{ݮKSAl6N4*?/V1dnݺ/h4y۷mC}M FSHܻS֌O_K'Oǟ^ ."&dwb/?_];gmy_P*8g+R (E3@J2hh #!eng9\áSeٳI/tu[޳V%۾ùk%w3y1FD?b?ߕ wEGa Vu0 3CUU M4u0WQ@(,xn1fLS4t (]EDDL&nZji5*[s3P,A`&Zp8d@X)$E>d`%H)p_)PB暧Nm) XX&h*TCqjB6mݞL˭j2ouTì^'ͳO}ncgݻ_ ڌk7~SnZ`.T5H8#|W9D  ʘr 2Ï2fs7iν4ˍws^o,;Wǿsp$YLG٥!E{R@5bliD)E&uR)㑔R,:+a\rJ.*B3>؃DXytȟUJI>b( WҪ=Or @wkk餺vz2l*&ia($׾6WV[|Î{o BEyV]ME14R)/.Y0'V a٦spp`4,:=),Lȋe)R Go=HI8hm,[a\y?3nc^>؏s=QMWQGZy ǾNjJK.||W?XnKcgjWt",3{llUT ^8(+usik3Rp9b\﷧ɸ*Hqx.B<'/EABՋd[|(9GvvvfUT5Kww Ţi'{mjX@afS@dFϭ_սy4.rZǫ7 YfLe4T,% .Rws}t3OnXqcG>a%C f$ڏJaߵx]қ352z>['6ǁַ~?^NͿH~N࿈bFc#ǹuQ$_y2\ avV7(,NR*kZ36Ý[=zb}]qΝAB\~\@\8wɩ{AЬVa<4R~`J.Uþ^֓1ܙ\p. c?֪6Hd2YkIQ9 63C G?kӴ&'>=4sݟ =ӪO7-amn]^t EBweS$WTm߃~ wɹKJ+Hٟ7^iU9xػӫzdn)H"Ӟ^i|VknZʆ~{|fdSOn\N\~]$paaͪdZ@K hD0+͢[m܂J[[響zQktwo駞 a )O٦;ڶUMB3rq8 )Q.6aɚ˄$bbPfgJcB@kE#`s{9ϫz__ЮK=jtz?} TnR45E6.|,N"2wS 6`·7oWfIt~15@YxlK<PSeʥl_k]]bO'ȋ~Z!L~)n eEUAQQlf<ߕ,5p}"&Ib u~[9@uhm\\8NZw-Lԥ/o(Rj׏fQwUڹOl>{ FBݬqHZnXDƶ$7onm/}[]c K<Ԯ;;wh6O{~(( :i;kpp⃊ɮ\~]ubXߕĐ-8wʋy5y~sِwfSA- jԙwpa?~\m^OqqnZѣg< w<B%ܟZȤj1dgUjfjgpsvJy}6&Q-mg(ѠhevaoQYYȵgIJ zZ#!ݛ=).2px:L hUEѿk0q*{{Vn?6$sK+WƳx`کz(='dS zI, ƊXC}Ȋr.xt|p~h( j%;Yr1l'4<ש+j5IS J8aK|sxз7oGm4 M?czwA \ (0O\haZ>!:D,OI$[8{BN#( XԪ[Ei*@"߸}(E>*YP0jRѩ%ރbT6g*kwFҹ$썂So`'@ĵrzHVjd>MRpp΄qwf^?`iwcT^Q].].hTw0r8g`2 n[zvj-tJUiTJfuU,Joq{s* fރz,Xq? 5r,qkvuK/xp2XDQTB,;AQ%qvVᾷ}{Y6Ϯ%|胼peoqD'_3 :t¬;jpKm|ud{`K ZꕫCO&B'i"R+-1y\* X^ ,۲$bA> ^7ΦaJ~ 0'O9^^=@9溊np3\_srupa r5I7x#Mӗ>0 o޺=L ǵZm>oFٶK@{}j\)7Y/ۏ)2r1̀3 yA" u`y;YIWQq̉I$qwį>$LS!$!i3i:I\YNdh6"?딣XX )2@$U ,/'DzIA%*C.@)W(A~A-5˚*`cI6N1,^@4@KL柾r0\* :Hv"(ҵ4N90!1`6gٜ!?ƯoR)@(ňyP}#XZбX)_?[[J{wgѣ$IjQ.w]o=G]<6?R _仞cXO]n6[BB%o+R.ǣٍ%vnBn-X]64.w$m]c$I;+|ՃquS_.!dL4'l pLŶe/ZQLy[QK)ZI D Iˎ=Omص,߲)Υ 8r1ŬD6oOAӛ)*)Ĵ.LMBKNIĐBg'NV~?HRӕiM@yfM_պ8% dO^T='#jp? fж4N667~`l6O`vȈכVƛ?m5ۀYe 3gt럾83,.@<]oQJ $ه6SgsՉKx+L&$ 5x^ ZZܕL fIF 0 )E ܜsw|t@eGXHnh7CEkiP (ߩbjv h\+$ 3-)UqLix9oZez q߸p@ KS*ߥ&\JЀ}QpTsegĂw$͟_dsFB8 c L>cF>EV w}V4jȘy:F'⹼b,_nTβ%߃ {}pws0^ӗ%<FQŪRX$!?GI*D-ǹqFs&ID,D" Q= y:ߕMKW_ yB0,N#n\OcaI \WarWvfBXYߕIX^3"j'.cz4L2Xgxrnpi%\z..,w]XGh CSȸV.$I^z֥KTL&u r ȷ=@8$I_RDZOihTU| LDp20@Sę1V][ZO'@^`D0$Z3\8/^έ99|ҏ T~2FѰ4.N48}F!U$,tov`%W\bl.oi$T6 ՝\tǑU"+kZ5GZ}ey98I]ǣA v Ԭ:Y"asFfY[2332c4*gW&sǍܹY}Y)OHv|qbwЏA)VSUZFQg !͹$k9a 5|b|2AC.D}*D\T@wQ;Ȑz!Q![l%y*SCW&J{7ooM҃+nTVo;@̔|UT]E#4^1D BBaW^?˫YJ́('D 4RD<#,IX C; "| 8l^4FTz2].%!1nvCkws)FBߥﭭ;_~xt\f)H!\8?(@aZV6eŸ0 iwgR|F't*0JulCۧ(I\.TD$axo۽^ I_.T=d}9E@1uTQ!1lB3G(FH9[SP?'xYm+n/)L#]3-βu#r8K8+א3ߕ)V\#mj[YߥW<͵َm$}f9 d[+zpwWJ9K?]\e-LH"d2TskqG;[{Wʻs5ٯ A+9$ºd]zt4Z 8R1|R>D\V"{0; {nòJh40lۜ19cRgLd LɃI!QP[,Ξ MG?叽WyƲjroL,\<5 <ټlprV _zc!*wV?ZO5KubZao(9:q eΕMXuil aRbTbΫY Q(swwz0XT J{8El>Ig9!nt:DD@H-Υ83)e,Y,8RNE 3STwsǂ? <9Z8U蘟Y_%:=M[:f#Kgϝ-Wa L| 1hSowk+U"!,ڥ$R2*R-pr97n '!jvI{<)|WݷTf]Bc(2dK` +Ջ+n/o?xxf7{c>]è.u:Νۂ$C6c[ԷXE& Wgy41b= 5&ժWMr;/GyJ[vhV۔ z:6WV;v%叝oی!4{ʉ ?}+\D{n*; $t쮖7S:g;7vGǓh~mǡ`2}+NW?qʇrK<a,##^gI|"d9gW4n9qJRz]?%}035h^ gn>wBP3~u4'{ƚ/Fi߱I 0 "C r۵p-FcٽI ,3 cD7ӨFW㻸oʗ~*p]wu_# Bd_u:*@"`(#]c<Dd[Pp^2ς Dwe jY#"0d:8 KUJ.Zw0~T7|WujbƉɢћ#$ߕ(cw,4sjj~eXopl1-@ Ø16c;TqxwYCgAPi𭭳%lYl:sN}2M-8Nٟ#CX"f/jRMM+Ke;(< ۞L4gwyW^~]1T+>  ]{/KwUh*Ny}[e\rD XI!b󝵺N$Z|j_ixG#&Df$$}ib>>| 1,ʓٌHR @YrNFrs%qq ӄnAl8AX"y_./_K83 p{~xpwHm`^oO֭ru:|vFkkkݻդ~Q$ѵ\ aQ=ZZj.K`qJuŋmyo+NU3D"$Wo!d<$lg_o|wΝȯ$R]{$ϬVwA0ل~n."h+jݷ.22Nbv:{F+Hbl@p-qx0O8MBߕ&)qFci;tj5!N,V֯<}bm6RVuyA۝f|Wf=օg cQMY@].៿b1FdQm̓8T*m$iLmH$P,@DZ__Ϸw›3Bxלr iW"MB8nJY<%x]0 G.]JLV%gavnw^_ٖj{\&UYP;T@0 O3woKch^|zV8"1ĒU"]2mo~˲tw4nmm!|>h4*fɶ!{y#/>[%sNٺrJ I!޻2]ZWwυQliǓ}ʾUyZq=>6Wu2fA$Y_oTk鄱+ /ovX歹?x}(VQ|ҹGQGTyzӅHe/>_ѥr+6'nwJZWVB?.u8V._c_}[?ME"8 C^k/{<Ξ9W_||K!E,ÒU֧>ҿz̲WV_fg)ۜE@3!1ɓ.EẑސHqZ:G’܍z[e˂!0d L&2#۲`wʼnXx*-ԻS|mmvM7Eo,Ue^w{dR=x]بl6[-u Q"wvd;`@/jl~ԙ|',* D}wqixMIٱyq{#kkkٴn[\غp:olgZܲX9̙;ַ.2n)/? c*[2r-RǏ^\w9H­6!|<>)ET.ioƸ纪 V`ڨ58Am9#Ј=.tfq^>P: #kiZp7gk~ʅl!+H2~ce? ѠTjW9y|WuZeGA*dTvm-&FvZJƵ3ok/8YHOZ=*j-pAms' oD FiYbluyyom|.z>s^EN"9X|3W?mewe5 gno<.bBJT d$MjVb!v|_*ō=:Ox= +I$ϓMyx};wweDb@Υ38M-q'$]ǽ;8AҊc9 g(DD!YIw@=oY 1v0[6c.D6yCbę䑑DB>!x|m߻'XYn ^q\7MyZ˵Y ϸq|Yv٬ R)ixQՂSާ]y2͒y$*[zn|WRͷݻ7˓զDWjCDBdFDB1U wew!>ޓ^W!&KΜ~=J4n-b'9@O#r$DTd Owڮ[B@K{<[bp@/,]{vtڽ|߽r>)"̒y($BuO}F=D0' ۽$̢t mRw]hB,8ڒ$CR$2%])e.i.x^N]? %{%18k/$ay.C!r~Ckrw(|Y!?DXJ7|) x9~!|Wwz+[.H }~}$˄q "0N;Ƴ>;}߿~:szkw ̓1yGTn2Fz3ڼUr@<(@zQ/(tAӛW>2N?KlW^y{i џ[(_#- 뾝aԼ~#I7~0vv;ڣ Lc]:Gߕ, TV|>|5͋`yaT`ľc1}k6Oso,V-و셗~=O䕈']d9~K!ͮ)]gHDM{8"\ ~ RcN)E*[YwBK' kya@*& LaR1>%b0gsA~,]UJ900%~/>=>Ǿ_={ғ.ι\]pO%"JQ b\Mv d+rƘ^G,"G;RSfIꀊ_.Qo|VA͹"p^Yz@h?"Ole&IKd8򥯄/RC/z\?yfR\|ѱIYLTg CPy1J$yV=KQ?Ab" (I]z@F2V#JNeH3y(B'\)hLD?r<̇?x]jy]d gtZ֑v Kg8Ϙt(a7:~$K#"TpUYŵ2KkNY@/<(&0u2$VwH[&45Y%Dd'.dų2BN E+;,bH]ϐjwm )$<-|^*9oVV$thE|uJ!VA=|j\YnW?*ߥg{Lx|g eJ KDѤJ/sF7qQ8Gfz#XȬh8ej(ކԢhfBFFwT27:H?( Z|N 3^sCҌTo"iA͐r-)S 8P (GV P*(t̊<*!!<R(4DzJGm(F܋DH: S*?Dc)%%aKeUC+Z;8WJ Oow'\bQܟucq RJ+K",jx &Ռ9E<ҌEy~.j),\K0S, w)]@)NOA@aaLI.Ig<30fBBGQ8IV{'%GY(5C|@1_2* *+^) )YL$MdEڶuzp2'Zf8i՚ĐS#o)Y.V5O4jQh'\H-T4* vWʉ/md,DĒg-],`WvSVda` @UkvҦ.lVL\͊o^o*C)Pm Z %UvB#0$ H|/!X?Ƚ +*Oz$EP*hE۠7$ Bџ2[]-{xv`]œ} t]Heem e31~IA * k!bֲU!=\>u?DRFz-Vg*# 2:ĐZt %%Ȃ "m ( URuC@qC[PrR!ڪo.+ĸjS:\kaF?aߡPʍ* 3]T´Q;ݟE"Uy9veȁN͵R c~daBMPlLBDAa"*{jS烐ZwB.4ty4W s9O8f`@ѧYyҝ%$NZAYT(B²t*"2+7-: s%B6 UbB욏UQ{)=ÂmyNP,9IWҷ/J[ÔtsC"mHjL̈́ghe+Zh-xQeY<BJoO3PBF{EGx3t/,HJΘEځ4|2!c 0F#hJl bb9w45Ղ.Xd6PLrnh*g'$}dHJ!9~\ O$Mq]'y@RJ)έ&߅g5G.Kr1EL~/RJ$irOs^2?o;;ϮnW>> p[stjIDwno]ҷzu_}n?,̨Cf{s\}h}B3^ͿyYϦ;?<^C- EпypbPR߅6ɼ'"g8_7ߥU '`NvF` ĩZe2_"'JAoqnqrl  NYT Z' j.LjXތvܮThwKg.\yt&"&I8ng42]ןz#d6o|vǖԚpWhsw~W aNZ$F{ix a{UƘH3J p(1DS  3(^;?I28g9 q‰1$s>;yʼnUK,v#I(I$KG/|ldIPg"hdXd`!x JA gx7.ܵ8$}2F1;1J6)6+%5 S2.-ȬM9W'\P""#z4u18c,Ysqҥ`צ sNLy)>.h5Ņ6bPJ'AwcـHϬ= Oxp,6Z O/MOc&\Np 8Kb-Иs v1;OU\Zuz/\zOCwI\0xi]IEO>'}-D,i\C0'bZϨ-wG) MNja_ };{zT:E<9Qitcz.'~N0?,\ ʽӼ.{wBZCΟUca >5REevԥPǮ-6UHqf:-{0 ؠS̿jZ!ik]!̆&űH+*j֒CDUm a3zD-qqi DJZD] fX2&f"{:wi/sFhhqɜQ3'.*af,-'nZpWhx/NF»I<0]DWj:)2rA㏢- Yc&%0r߂RkAQ̡- Ii=ZޛIr\㎼שׁ@8((Pĕvvd6_;1he2ΚvfHZI $h4꫎;#*#="2QGU=5 0 ~ac[.Lv7(ܮl!H&M(yQ";A+ $<{3EHͦԀob8Τu[` 0fC٬ % @6%+B̀{&_d6is̆CfLP̢.%|LHHiPkj'X59ܕyo-0d`NO6=Ҥ(zεXYB^f#AɏؕYsNKKEWf쬠:Kˉ@?_%htXJR#i ˲RAnW["{v>Rd2LXSg;Cj6&G&of[΋>zZGå}g珿ㅒj4][}RLQ P(f庲ov@f A?:܄N;(RIɉ3 {o1wJ'R/Z_^ wVk֍{Հn׎M8ZܬO̕qz<*n5珸jC/1g\j?NzaqVw'\o\/ ^neX'o~Fd>Z~^ խiG/菙{SS|.tb%)/_K]Y,r}iz9G٬ˊ, UoH/cfwgfw>%;6ڽo4hlIRT:vZ\"ժARu^w2!/8Sw7?ZHdƝ]~"Od 5!p}j uF#o4)v6M_}~u_nSW^b$ q?8k[OuS@)"դ 'Ikώ:>Z?xJ.[$/{co7 ŭT !JF/?J_4n~a(޿;ZL~O\N!exO؂D:9,  bi0{ͳ3˷KW+aAxDsYn|Lq vn6zu޹UU+9`iyUgZ^O "д2۬@MEe?|mS܅~bx*uϞt}Tynyny{~e B? ?( j>Zҏ.)+HAQzV߻](Dw?xhwN;\Ibt^5SyH .wVU~|Χ=daQcw}̋V WB 4msJeX h M5jYXX0 r[J< >lZ@BBGdEkU pOG!-VeM;0_kiNzL[p/T$}N$Y)eT' C6MMvGip:Z2ʖF[5czؿ/rVRpqzKҞ8q9IgZS zdq2NDݑŪ̱T$MRo*NxF[ehh29$bLdn3YFNNGr]:RMx!`1"]`$qd>cnh=}7ur]*b̦Яpx'?ߵo8z<*Z SX߬:/,ͭ|^OӿDyHsl8]`o2& $~,Ng| ;'ML_Lol[Qc8sgSS?f zkDnІ2*3Srx c @]IY, $΄&W-9[uOHABvԨ_,z~5?@>dw$#RI2GȘ":KFH2Lwjj(32#f@a gb]&i`d[A;<%l>lQL0-̑^CX)aa 6{ s`?tqY͚00^i 4l]6Ce0l1QnPb !AM=`lwA]y507X_|wAd42eev6ouΛY&Ꚋt#ۃ"#dWL<e|WHR6== K?ܨl6<*쌎gˉDYKO,,1]\y?/Ee#oI4]VKeEeziiffb}Ū! O{t滬 ]7ntTk6;cg|F4fˋ~ѱb=6b! z77S8Y|^kc#968!0T-9+j'8a|8P7, ǎMxl},[]v^'Pʝ\6vw~\ߺ~N&7jF2Yd~W_y${t4МBYd!`+yZy ] kǎMST*FFBC28(sȄ,ƬkEz6l.a $Ii:##JQ(T~Xd~~zeeG(*ϳswf&6=="I$Q(8Y8l\C/푌oy}>EvԨ_}(|:365{XdkB&,5l P;`pJHI %0-ba{;=99La˲.B|0⤱3pր!ay&LfH L؃kL,B02 Iܓ5& C(" HonEn^Gbaq,6džJLdy2&0#}Hŀߟ,B˲ҍd[,jssAX h!|W.VlA#2T4M-/{w^o '&:ZQ*#$;;⪪V mb8 msg唰؆?.O$rds*U(jG^]ygzduo6X\j6E@nnnlqq{k+珬Ee魭n < k_LVk..n?̼!Cs8wz|WfKn{'aבaHU_4X "D`"\ciGAicKCEJ]ze# gNGfY!J4UXVhYTUeExKlaX,3gw-}@g!<#;%ӆf0?;|MP; E14Ͱl/8+>.|ava!p.t]feEeYch:,4壅^!@,c#GeUUƃ> 31_mZLN0EeJ-hBŋO>%>`ГJmil,p>K?AJD}t:MS#fS RgO$f08Y9%,,!fO3:b fQMC>& J $4IB.]8F߯_0wj&SVÉDnmmp#,E|>_Y[K$9:/u%F҉Vl⮗&EaCw-(Lk"FO#+2+}]D62I B[ VtǏONܹj:~|" b-Ѱ,sscsw7/[C4M=ıthW$|iMBv]TlVZ2Užl3?w<. |Wk ( %yZ tdcl؁[m:w &̚S)Hmjg2.A0Vz{(=w!ؔ~<\VbN 0v=Kf7Tw&w00oJ=0[ww=HV";jԯOq@v9|DX;vl|uu7LO7L42( c\(TXTdgENF0^㸾d:]|SFb6[.Ґ|WX{ck_3Sߣ+˕C!o*U$鱱Kå'&77Z ^|KQNGv:ٔD"]F%а:1~heY}p& ]@=LOj6&Gљx6TtDՃ۱-/("&LRoO2ԓ}ub楷n-eYA0iEC$ϘkqOO-R~hf `{P-. r`'PYaZ>`c!/:t@.,dDjEg0RFad+zL0ޚD& Tkl,rp0vOphNQèW%fgGIZY4FG##et{+Y]=g}O1ߵ=wno/xv t66Gu~κ\b4y67SѨVVsϳDnl,bāfu" A.k^@&n,!3Z&jub ܑť O;ez (Ǩ[Ha腅ggVWwwwѣcTD6e2[[xwf!EʃMUy/*y맓dh@zy&~$ .z|{asX wO& F gxKΑK_Vܘ#n/a/kF _|"R7D=;`h1u1dZ& "KDdys|݊|dwu[IRA͘=Y#󩖮 3X5fhF݂?C].l"{wfnZ=?~#i߳ v-U0ԉI׿? Udh=%3ya_CO {s:w}jwhEҭLJ3>$U O'ϋyM?&.S莀0Z03ɴ~.W. B]z3Ϟ٬5Z4r].й9w >"m_n4ZK:'\~ni,Vyzf+OeI਎BFz޼^<}s1B'^0v2fn'ȶlZn)_, Q+uEw>l\lYP&? G=>Zѓ->|&%v#}y'3;|R/>yj/^`߸^ p!HV{Pѣz`l[QWOMƜ؆`9еKXX(]Zm* Rp!ndhzbUy~l7_gwn;zKjKNbr 4ZO4߼^].)wyU+'۪K5 _WmuTM;,$ ~X'÷k6jA );?M˭cΏ+/}>J52 9`#,c~]9wݩ7t|WG~ȈxtquϞ[԰s3 m芁WQOh udm(Yhx< ܄-KB{O]z XslFnVN:͐cӧ| k_~*)Ia!ntĐ+I0ϴ#>NQq|୍ڗ?ԕh[a'ȶu!?~CzNLno:s1Ū Aܘ%1/?8b7MyfrGN&QG( ThG%E!)dĤ+\"KO"99t^ew':]>r֩Gd'24;j'Kǁpc+QoӔ1_lIq?sm AOv_t;oJb־Q d2etޖɚK .xАc!4rY0G#2vR25h&cYmlbΡ9}I>xaL;,//u:wygdd\.OMMy< `c4yEQB4MKxxZN&X, h4wnléklyyyll,J@XOf\V~>-vu@ K(ҩ{]X\ܹ\gf(|X,L&~,pRH$~ <˲Ej5A0ƕJ%Z- ,4L&5MbO<ĝ;wΞ=[,^/I!eFHD(qV(VVa8Av*ű,iMQn5gk5z~jMcpUE.MG'lѣ|~hhpeH$)f4Mx`$2d@\ǓdBPP|@EqO&>rH,3UL&3>>bd_w w1@Q(kϲܤ(&,9rn_|T*]pP(3 aenlO$GG:[oKKDBTOCKKXZǎ!I$:wFllNp㝉 ac#Y*NO>t:(bݻJ{9v\oٳg t ֖.=k׮=cc0fjyy9 BVڵk>,Z655EQ[m߭]f^A@gOC/˞Dz]}$Irsܕ+WVU(BP$H$yo4jn޼t:WWWr677s\vcN_uVU4($v3G  Νs~Q^Zj=*Z^3P(z<uWԔ##|"!@0ّ$ 677CЭ[`yyZ Z-HlooͭZ ~1i {\.'c=fL7'OLӊ[~7ߌFz"OO?u:[I'C_I}ufPrgt(2ap8 T*Q٬a;%`+^/++Q 06Ƌ"-T  q3?p8(3q;9/-5[۝lVYUH-.e^ b>xvX:35M].CP:gYm}tzW˲S ) L J,03ݽ:  E\0Z-ZL(LQPҁhЧNkzh4L&Ƿ;JRr\,ժc4jHA;~&JNL B3F8:j9r0# ;9-w$"rT/..~+_Y^^zv{fff}}n={vggl VE;wfffRTPOU0+ 4b811 KnZ-V0QT77 qXUAQPC KC&E\y-Qyu17f@@jϧ5MVj<ϝ;w`ssjEQ^V Fn<:x\U^xacctJK? \Z.0taaݻ c=fy=wnsЊ5ZjE_P [c y]%`/BN^x< 㼰lEQ,Vj{4u _sHӴx\GbMs}zʉbgb^$JM Ѡv;')Ti&,hTn<:.812I%+Vp\@|x\H$ƪ~?EQ~]7l6 Zf;(=+ˁ@ L^x((Dh4TFЫ)@I$$[ʉi֜NZ\14eeZMENGrY'%Il\jzKR8IgoÆ-ND"4-ݼJ]w:g,N*u}h~0W(9}|_s2yMW0K @xI--mz4gWO%YoKt߾p^T dԩST* ]v:ujkk+鱱o߾===}ҥӧO4G x< j5դq&ԩS}ޞtciih4 aЅ Mj'&q꣣PULvNzc=5%8+|{ !b._~K(,..nooߟ4Mᅅ4V꫿[E ҥw''Olmm`0=??Yp-׫ol"؊_?7nrvn\ŋW^}CǖdcwI}^I6R},r= "(;e[~rY˗/1}Gio}7o[nB!/_\.:N,?-bYeFqI=1N8###NgjjJ?bY\z{mH~B%N'GGtZ*r`tl,J'OR5MJݻG +++@@x L: lrItҥ'O.//'۷o_fo߾b1v=22qΝJ2<<|ƍr|].r*2,#?,+ͨ0{3>"$A̸,gldAwo%oK/y晵h4xzNܹsieّӧO_t)}:HLOO|_~~\.OdY… ،_r4|@?:<'nN:]GI(Vbt(j  HQHT*`PN$mIbC\@g }w:dgҧ ].$O_ES .WݖȼH_E&?0:6|Epڵg6˗/{drww7ϟ8qt~nFeY B,V522$)VKF![i6]>cE٤dtIp"[,OrV0lҊT4!E|].٤A)Na0D"`0/vXvWWWܹp8x8p;H$zzNyaaAqnk611q5M8wvv)p}޽x<1^\\TEp8\(Eؐ$Ibiiɘ2W''2Vp![TRceEƈܯo!i֛ S=e/z}XWqOEqttT?h=55G|333U355FWWW(X,VVO>-r0`'ieh%_D$__ipաáv<U?3<9%IpX*=+. Nv0izdd^\fj(`0.~nРZ-IQynIL K^+d273'U*m8a<؇`A[`NñE_刦_1([9sj}V/^Ny^O^>"z(kn; ?駟VE'&&H&]__㒄'^mMO {{I sx ^[k"57'V*Tj"9q‘RoQ1F;:,huu옃Q8N\Rs8(YZj;\]mQ d{{̙3>,ܻw/?,ˮlnnNLL_|8wuj?~< gϞszR?l@zcAollsKK%N' Q D$H<ib(вGi/Ap(f|CG?#Z:_ ku htrrR.X,+;$IO=˗www=o|_?/.///ɥB!xv[J-TIٗ_.(ΝsRF{vV(RIv:ZMn q~?y{$9uNv>!LkmB!)L&/^x#Hf23d˗d2T*˥_!777B ҁ0 CӴ>B_eZF[n=/_^___5á=eQN:@ξ}cQ;F>vІ٘{]tk{{'T*<Ϗ9sΝ;'On󭭭:P(O~_~_ gϞ}w;vs}}}rr͛F@`ht<?w\:=s֖w^( ;;;ƽ'H>"t:;V q\. ;r"Ϝ9s-iZS9ri'NSIN"Ky]i;1vCŀq!looONN?v!ds2f**E!A7rѝF114>=Z, =8R8i vA#Ϗ<@`fPVAJ?9ߵ>,\dXW}H{F3 B?#߻{Sy^$-jsAPTMgF^\.^X@DQeҞMkHVSwiC4 *`PUՅt:=77gkJ;w6778 6H$j[}>_^A?rld}*:08 D087fHD*XYFǎ)wz4Ml@jx=A[پ\fΝ+mn{$Rޞ'~~*<ϧǏSE8Barr";(*7onLOOP>Ezy^n`gEfۙlbYb姙2mH(G?j^YYF^ y~ttΝ;n[̙3lVoDžJrzjuuP(pW(fffBmÛ(jf$)@٬:348m^U hN_IBDv{$hPGRyTbi;kTK_- 3LD"/ׯd2Riff&ꛄV[ddY[[|W^xZMOs z2_fΘJh(4gfm,#[$tNJM .%N \oDHwv+LW!(ʘ ~}U`yjl~$ ǗeBfC{L?QQlQ_}w@JOtA4lAgg[{!(g<~" ]gr^  ai$ VUڵkoƓ'O~fp\.dYܼyF|X ahUTaHS;K%9t 2IKT\NN$ yyni Aw\NBͦЭit:ie*:>>bnFVz(ͦ7[ͅ/Qahm܆n,{6 BbM'bb#x@$\a\+e{ ػmK9Q#FEvD gh?\.}UU(J?88XYYA>AHRRivv빱͛7A@ZJ>ub,˚Ml8u5j5=#0 AuŋEH)ˆ NGBQC1tqr"\(C:>}g?;\XpI׮qV\)IR:::V.+͢wNNNX[[+ZA Hf\rxx0LV3337o޴X,.--ݺu룏>^n޽0 rt #A8 (Jdy] BhtqqO?EoujJ-۷nRtzuu`mmΝ;GGGϟ?o4㼂lllȲvvvDQf~?|>j^ꫯ.ǃŭIs&fC"xg,C>(?y`)U!`FL޽hhlPp8E<G#:rq0;;{|| =(FL&CY"(($IKKKFCEd2Fr=|*Zhii&@gWov 4 e٠(xv*۹ܕ7p<;,] Qb N'ŔeP(jFp8ѭ8$z=tg=gd*a0L&ApZd2'''@vD2H\^#VeYAPP.8P0Ѓ6Ry61 w Eﺤ"ʣ(ݝ}ġWedA  t@GG={-àx`cN ڤzq@@z:GN0iH!l E & M%e`8WxLE1s9\uwfЫh `>.ylJxuˈ\΀EYQ$NݦN#4A0x~wbuQ$D7Z-Z01ۭ)%&I)niF A2!;1O ʷǣIPU}n {y3|Qhژiިp= y!rjz"@SUv7'g0:V0c^2$l݄c~Iً*)`<04`0b< Cߚć^`ydY`"Ϟ=-J9??svZVr@?NFnMWy x\q:+?iχnmm7O:z tn ={655U.嵵5]_xH$lXT*X?A\yP(Htzz( ˲X0~lqJhwޘ+\n0fR.1dw^%lLh{#+`pOhRA 8^ ^?4hWvсť%˅9*j& ~ LӔe9핕d2v[c4t:'#XV+Y5tR jg˥Ӵɲ׫:+gݺۭzXL:>vȍr$rɨ*\Z)42\.MhjJ,OEQRTJ$Nb1 <|rݵZ 9f$voyyrE=uV5;; }>MөT l<ʲ^r99;;+B$AD3 _^o qQ~<dRA]|0}>Bp$I14Y:: 3@<!oC0هgg Ta|WW=Pi/IA\foT |=Z^v ~ۻ(Q|UvO r}꺎uݺo{yOH5сBaw 1!BTZFdt$i&Aju=~м2ǔK]7 ì՞%oud)`}tX6d5U#8(gH9&_[@vቴJ϶EQ|sssz z ޽{7ۿqnzt4/8褺@T*q/\as9#n0^8=BAv W˩x}떻PIFt%ūW9~v @|r}*xQٌBannP(,//?}G?Q4}YPXNӅB?1Y7G~'оǧ~[[[,|[*x'eٵ[nq>bxFz>~ mkƲ,ph\ӿ129Lz`aR>S"Ou:P/,[[[nݲz0і5mڅ &8@PU`+?h1c^ >H۝I2OEr??n7 H9AE^qaD˗T*JyO㸹9QܹH$(_}ix4mqq4m??Qh&øH*- OuIוNVy., VDU?PA-hFʲu BH*4\83Ww!M^/GQ,Ke'4TUSQ>_~FMN0fW^Rx 4M* ^AB>4MN$jKNQt0B`&z!jt:}rr 0+R{$XX*9hڌ]$i:<;c ݦD\YQ^J k (܏et(rN4Y֨V)^zK9<, ?h?ZE:4VŎ|M"+U*a&(`vvֺ`7^kÀ{i2 N%IB,"A(9iEi2X]`PlBfcahF|2l8a Rk"f @(02k/V>OevX(*99F\}/ $I.,,looJT*{\\\T*d&-R0 @X8NԛH( czim*Ѩ(DK9 :,kJ0.ȏ!fBxvv>} BzAe}j0 Bh@J%43ij5-"0nZ"ߧb@ Yu4x2zӧ9NI2u>CVB0==dwl-ID4Xϛ}^DT[Ra ggiNruKT* ϓ&Iaê<"v^wzz:6`0H$B#.kff)DMezL&p8,2 Aiq\ZEW---΢jy21q">ᑉՀY%) #9u\Y$I$Ir].$?U$ Iv-{R"H8F,?<#󯿍Ͳ.o.[zq.tZm7vW( i_1L$@QF,&` ւ́4̇ch%ZWH&\]H\n[I(QT,kW6'cٜg  & 8m-I#-L2Xƛaà3OMC?F[o{]{ T|w4!Σc+3.Lbp  qe8= u(NJ ><m7GOJcA v9m JdQ-C0 0@յZՀJjkyE4PU]Uu0EuC5T4on&Vӄʲj$4n t@+4u__ʆQ h<a꺡芢j(atEѰMU=OږEMӱڻ29أ9:8p> q0: - X1ž8d0*v禒Q!>Y6ei0Szx:0 4UUMH}v C&ʕ+ӊRǏRډD++N(j*)kX`f&vxxZw4M<÷77ׯg^8 I"=xz_l[Pmaf&͞ pk(\2]w*}u z$I1 vjA(_b?}w߿L>|ӟ!͹\ZxAe5DQ$jxTj 2SHxͥnW>Vxדߗ8yzXj7ṋݒR<:9)ݜ$SqhpЭV%Uơ|_xE&ys!=8n7˒${<\սre{M^׍Hok7 ` y z<4AvD"UZKK3''n֭ki@}n_:0T'd2Fo'2 bZ{AD05Mw:~_-b-gSSF_ZEUVwMg$EQ播Vu5#J)F.TjA@7bjk( RBsɡW<_ Cfř4@ljňxx28uqTEUєUa`8u`ˆŗaM(Xc 6@-#mYV!:ꃛLA$e\UU I7]HeRʲ0;?TA,+ v!YQTH PaA)*Шaf7>:Eg?kdq!>#.0MS˹;"]Ri(ϟ)Z?~߂3b*8`i2[8|ytbw`3mMy%#'QmB3DFhAӁ~Dik0̅)ϿtOv[hh4nw??X^N+lV/_EqcEU-bdhFH[-ak( C+WfN tʲi:MZ.&@4}YVi4 x4A6[B39wvNVV2T`iF__/3 NǶzkYUU(\(ԐC^V'?;{oe۶%Dd+hӔʕ0cTvvrssB,Jk h6y@$}`4IDa0x  Jkj*|9 H"D(w3~{f&JELEߗsVkn0:IT*N‡% $Iv:d`L"| @&8|V }\6[(o^XU*D"47>t:iMhz]h r%vF("F"BUf<ٝ-/!4M3c39ش[[A m qҘ ɪ:cs$@|0%<\cB]ȱQ7W)&=b@%].""viFH`Vo 7ǹ~"I ptz|g`Ė 3]p]VՖA5GY5NwAK0Z 9.kA<?$4HAL##֒$nİ5^8Ps}v |\'Ov}>w-i*,h;KU z+֋H][ۏF''@{tT>8(RnW<:* gdN=Jj'{=)-u:IBvϏf..dY{ddEbƲzѦ,kPy2FOq}/4u=R#\ݪTPDzssɥGݾi/pǃn!*Evs߻wdH4uB2ƛOL'/[c.]D|H Dh shc,13OCK搩mq4 50 дژ+A"9xZ}zTsSpBxlp0+Fo6`гlnftfAl72n7!IѨrfwo޼9)2AKKӨ) ǃsw:D(rX֎ǃ pt:*F(;.Q+R;,+ЏC5sy+یㆬA|d2}#ɐ&0Pưg?YfJ:ԅqyrK(c 2KZ%IPwI#\@yEIt7^+HJ3C~2OOϦRH'a9b;_OOkTݹ߅߅E1B endstream endobj 204 0 obj << /Type /Annot /Subtype /Link /A 205 0 R /Border [0 0 0] /H /I /Rect [ 233.2425 338.1166 244.0845 348.0372 ] >> endobj 205 0 obj << /Type /Action >> endobj 206 0 obj << /Type /Annot /Subtype /Link /A 207 0 R /Border [0 0 0] /H /I /Rect [ 244.0845 338.1166 254.9265 348.0372 ] >> endobj 207 0 obj << /Type /Action >> endobj 208 0 obj << /Type /Annot /Subtype /Link /A 209 0 R /Border [0 0 0] /H /I /Rect [ 254.9265 338.1166 271.1895 348.0372 ] >> endobj 209 0 obj << /Type /Action >> endobj 210 0 obj << /Type /Annot /Subtype /Link /A 211 0 R /Border [0 0 0] /H /I /Rect [ 271.1895 338.1166 287.4525 348.0372 ] >> endobj 211 0 obj << /Type /Action >> endobj 212 0 obj << /Type /Annot /Subtype /Link /A 213 0 R /Border [0 0 0] /H /I /Rect [ 287.4525 338.1166 303.7155 348.0372 ] >> endobj 213 0 obj << /Type /Action >> endobj 214 0 obj << /Type /Annot /Subtype /Link /A 215 0 R /Border [0 0 0] /H /I /Rect [ 303.7155 338.1166 319.9785 348.0372 ] >> endobj 215 0 obj << /Type /Action >> endobj 216 0 obj << /Type /Annot /Subtype /Link /A 217 0 R /Border [0 0 0] /H /I /Rect [ 319.9785 338.1166 336.2415 348.0372 ] >> endobj 217 0 obj << /Type /Action >> endobj 218 0 obj << /Type /Annot /Subtype /Link /A 219 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 499.0358 237.0000 724.0358 ] >> endobj 219 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/influenza/files/2009/09/136k1.png) >> endobj 220 0 obj << /Type /XObject /Subtype /Image /Width 269 /Height 300 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 269 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 554>> stream x1 0 =ll ּFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnF]C endstream endobj 221 0 obj << /Type /XObject /Subtype /Image /Width 269 /Height 300 /SMask 220 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 269 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 79640>> stream xgu zNUu9͝ r"@)ʒ%ɲaע-{VrxWZ[dKkZVXI%YH `fЩ}oߞ;~~?\7ӷԩϩ;BD74" t q~h^v I} Aw2o|{kv7t nAg!@I 'ZgZ Ǽk]eC^ /6ՅɆ b>;!kY3Ej$ P˲jumyX`"Mz\_jOwې%䫁ڐgwչ~i/ykjmCv:AeCi= ïKL_rnv=Y+Abk _5ěbw{ߟ} >8>{W|ǿ ?c_|Чܟ-?=oRL@;O}>~{ګ n.__>|=/~{/BDOxwnr>X5}s+?G_~_xB^?ȗo?w[O.2^k끇m(IWH'5\ ]݆4y%ЈH bR/eSuԡ]m*??ve/~Yihg&TS>3ߖG>yc/]7=co~u=s.ێղ'~]#}}kmϖk͏B?q'#{GώϽ G'm3s3s"8~fs>uS~O~K3K9Po,]}S_}MVw?{MN]᜽7E+f;>79yWuPoƧ~ݸΛ'?ǿ~@Юc<Oo/k~'k7g $WG^GO}_y^kZu q+/疯^9$ C[ߟahHV߹wzO?o,u߷cOƩ_?3}/~kx뾷Gzs}"4/?z|)xb?◾/^?^^^(~s=܅wox>-%+~\/B壟x|f{* lv`M~|l >msRs.~꫏}SvlJ"ũſ#3˷ܟ2pԏ&f?^{'돽o'ѫ툚='j婓oڣ'Z{/=Z?mo|)]?>g<)OG/M-"z|\=._o>^m` wYWx5_J`n{wZ#"\?KKN_2ݑ]7z<ܛI;8Go?|DG9c=JWuXE/< me2=;-'`]=#=6)h.Y _-D pnC46ի}\?|խGjxn _ \ȯر鍷^75o?y}YyQ]ooz-Jr~xM/xݶ86Z}gNO_?<'/̯oٿ[N?őܾmϟ2vey@OM~v0>wQsϖ}M]+DO: c}k\)y^G_~pR֭ݸ•]$cûG鷿O.o=md wf|ԥmpeqd w+yW9xpN\TD+z3G ]v ?}jo޴ɾ\w̯a=o"'0Źҿ=SKWADڵűl۔?uiv;_w3G^x-1+5o;23ocK-w#/^ڿ}uۇ 릟?n`6^vz}/|',L/a}s7\† bC<q@T1J7~kp}{!p?НWrq | Dp~#_;~m]=Ǫu7?\Pa#Ֆ_X:-o \vF",GXLѓO~if7> O}@H_:"(/kp0oBl=v;qGߍv0;nRB xxFD;j@Nd}6A[Ba{Coͯ:Qx]]SBxl}B !mG8L$Z ģ+0CkF`ˮٻxf`c.D@x  \\BPjϟbO)$B˂sPhM6=  5gmCEg,,,AP^]e`"4i %= @&QmYlQ^D$%$F8ʕʊ0gX-.~BAWW6;$CX@[&,C6ك-PyAk`/6jz%m=0>m m<m+آg-ː"fKKNC6.mc,&W*P T =)yشJ%ܺN;@"8v FF`fi ǁ!abP|ls9Cׅtb1ںX])tHielJpq\/_|*fP#G 텩)ؼu@DMn,j8="siPFerB<ժز;\yemf&rMDB>l:~p NLF"RZZ2deM⢑NQ0qgg׼fնٕ+UsZ\4.TyC[g!@K!ҙz܇7t儷w;n3 m $j +|GF9@$!ѠsѶM,s\[]d+A4mŠT"@L j@ss@(&m  5pd{- V,?5 %.tv<9vmHF"BlDzH$׊D$@nj1wW.^`,Z<1J3!0Fy?d BU:@RD/mI5NnX^[j,06a A7wpo{ щh|пÕuY\,g7"ǚ"4 y~˥Lxc{Y }}%t-sC9=DdOt^jҥe?B~aח jN~5|W3c3nC]^zvl$3:_ ݮ5݈ 8lPjbX{}%a-U;Ǯ+,0$HXE a:tA/OdF$kGFr :sKOVJc njgؗ0 W"t$f[++ZSn Rb& pƗjח1 &Wke/cR9jIEJѾtҜ4&#㦦 HGJ,lvKFǥ}h|>עХr}v mnv 5t^Uɴ"T*F32&'I\n֛XmE4&]L f USGd \%Г|KRgr3-?Pf}O)OZwܺ#{&"ufRn;Hr/. DRҒETTIFz bU"gs(}ª}01Vs|DD"Ű3S";$Ɨju+֝ބSڑ .,TTBlY|g|k.8X99r-O͔V*mM{frudEMz?66sQ!@q-oM;A"#aw~cܡ gp=ͺ:׆I|{or2??zn<ܻn%&#ZO4mθҡ-٦+͙.X<*6db3SvSjj=yie7SS+LHo/iB\*-5w"yX)3ZTb=#=z~(iDua>M I"خ$5]yllf{Smz66gc Ox֔bCK j9l\ŌY9SHp5וd{uJũYޡaMp1sޟaN6>'͘ : ǝ-XSHڀ}]lWj e ;v͗HRZC陿䗶mnI$ʮWϚOׁǏ|kј|=w׎5^:=x-lLD-/LTGݷuK&%@۲*".-[t.X왭Omnz `n Ӑ+V"HivgyR*RlpM70m;z=7˫5'f\Ƌu熑\`@PjNEuᑊxDdrPɹٹҡ99/T.J¶jEႳΑt:F[kwR{rlWS6d}G}Bt+A ?.,nٙUjjQ:'5Ǎ$M <7:Ұ]HMԕãT_ԑ#"nC`щ 3Qqm;v=yaRdO8쮻cǎi~Y\\x<^(3OR޽ԩS{9wΝ;=ϫjx|zzz>&_җ!O>uԛ&0McJH$JnϧRbrl&v?Ng MIl]j.XуY uF73ĘozRg%J: "s@JIEC .tj={t_ZZzki?77Ɓ:泰Dvn"""3o&rI=5Ǜ[r[LLә9,[6?HoGjqL42d@)%(c0]bD8_6//׷qk":gp\]~Q1T\E}q _ A*549B=ٙlDEt0wc*::8]̸=r!Í&JE*?C( z %!٬NܵQ" dlٔ:,FV^ƻ=F=JIOJ55]:> hj\yxgLI-gD5˵|R4M6ktu4V۷oO$X,T\.NQd2W\ᜧR|>ﺮyLjse2D"^hb|>ZTJUu7'_=p@6go9%Il1u| "jZtGrwb``j("ڞ 9",լs兢k!qJH"JcuRD Pz$RRs83WԽpwN4]3lEyd\Š :{y; j k˖4K)q]*4\F{cKeZwe- 97lM1Y5Y';{93 "Qӱf}Oj}lo#cfJISۖOty4 qM]O*h|XأhO# RӟړPrʥ2[UUn3Gu5"zgn單B! ڽwU[l1R)$.F9'My*4DD b,\$j (TL+3È`p!SՉX>oPlsJOT<RD" U* pzrÖ?8#2D@/77gb-0DEI ilTttؘ)5JuΤlxu%ŋsMShuǾ|O_o;R}b]YnV3;r%7KZn?|vw?f{VX*+]c::Nqeee)S{J!c FFraq.ZeGE4nh! IR9KuqM&RU?Ds7w9D"13~mK MG,Kmi #/oI>[f_/Z, 5͓ (N_G@ۓn텕RFfXߒ4p2Q 9 YCCr&'cjw*s"bhecF'.-낹j:qH{jÈJulA63ʗgJqbilT qlY}>b&I % 6>>Å0Mcii)+z}v "a҉biƒvD _>i{>J Wa( 4hۍV7hf=SkDhj 1-!Vb9[RƶN# $"NnЉUJ1D:E'uO8ߛ ۬S/9𙇦3q̕o{{O/,++ \>Op,<:m[6Zr_P S؎tI%l[ sDE10ta qD`&O0DDWўʘtۓ[] mrZjMZӻu{|)nb٥td{_</WۆܗVR-74ގ-4_;Ѕ@o\OB2\ @OR_8͇ Jŵ[w䒆Vh.ghٶ2Z_nݞy(GH,L,=I 8#"TJ} &7v+/ڿmtS.kssΜƑ2ihkrF$Ct%Ktiys߫fjqCRyʳݦbd HEj}Λ04Mu59kz^D<1NiM+{ʫ^<1Wnnprm>\=S^PD+r9FDiqk P& lGXlTxҳmGhBp.=]zqmwl729c8)jXnDզl=~ͥḚR)Ch†#`[+ZT%l+kLgm4[VT ;4_]߭lߗԋd*ޞfyuǭ^:rv"8MćX\Z<϶z:}z.LR3@"g mm^BJ% H"E#* 30wy/i޸g<>^r\@/j[V zWK:%De g LdTVrRMTvcO jɗ&VP*%1`a@vpwطvLZNwĭk@ (1cPs榤sۑզ,V/,}\8U 8AOt)\?4@OmsHZM.4loBR1s|ߐͦپ~OE  Y6R ɯnݒcu+fPf >\5]0@ZDLD!:NRpnL\/\Xh1$%d#&M#)ny Z#k/ߵ/GA+ĥVf"C\vm󛇇'&jփkR1|Ho""LǍRΤ X.I 1/IvM#C[/lת "蜻ù 0H0H&]St< Z4WhVp@HQl6#9 Pr53 b)bKH"Ig_.TD\(m5l(:J ]`|Tl*]J^~p\A*:נּ4<(c2&Iܰ1̖"l=9ןXqd8%BIDyu9cr`̯`Ab/BVBP/՚d<%( +)}sNDT'O>̳۶o$l"e.P4 Ct'dD(>AJl )Q\CW5qVw\3'uR&zRz4,%P:\Kq]}V}F_eu~'tg._rvdfS1LhooEk7қ:y"8{/˗ ],..+ri`ЍJ<Z)W*9!2hjGj|7DD y{*|NRK˶ "ZlO){؞DDTP]SEgJ.8Vg{--C" trtiz ycs _XL.1jp#4+loNWw8vi?yefD';3[NksG;W[[aJUm}CQ zRga A˓o}[{ .FQ!B. F { dC=}+H6*n?0uy}q]1X5g߽g`bjMwBcow%}^q3ss@?5h_%Tyf+Bl//ڒi j`7c M[]Y1"-~To4-6/ES'oLY49jH1}=TL053BTF)sragCI & = J5Juypb xJ)@|:+U f|'!) Ϫ89< תw5Y12Bl~B7Tnz7f[)[CUry|kro"ixѾ޾X,fǙ_Qc0QMnUh;qrؔR5]g}q3 h< 덾xۮc ~q&w4}[z omGGU˥vvqScZ>2I \-׌h4u<“J.0=:0Y˅>jS <4uOc,GaHKsDD9hmWl@{%^Q}ۛ;JR OMlּU |d0[~Hֲ& M|ז-F$2W&J`|4#ϗDj8ܨ޶ Jn@*7*vj#y0Ж o9޻/֫WՁbSLI4cр H c 100C9ʖ@%RbjS\K7w}dK$uTwO{ַ^^/dxʶ$tddfRTDJ MQTBH/`,)-:XnMG[ z>PNk{\6d%nZ/, UziʍDꩆ{4g'U }/$%C,bRȁ1+"P!x\qy9)Wsٹ^'%MOG* u7fb;c\68KW+;F͚Ld,M**f<ӧ\8ff^r>3J(9a+`raƂkČqv""7,-/tBTEDD+84J2Md^ e\;>\XڞBȧ6*7,IhZ}goOf|9Kc|N&Kx)A$ ̄QdS@d+IwR2| lۆGqւ9/lE$tGlYIRC./ƂלZ/hU kTc1HyтX\Z/uNѷHL@P̏-2X-L@ɘ974E񂊩sbiTBN!C%v"!x4ꎂDW_xJvވ3qƭ'ݣBQrƍ_zy.7MF $RH *@&cjVt XrKD %AaZ817nZ˽^'cS)fAmJSo08}~qahfs49ޚP%dʡ/*c,SYc0 iؚ8)T,gRBM)g,bH( 4)xP"fUJJFtv(MfZpt# Ѩ"lChM&Eo,W7 c3q =`0XZZ FԛMiw:]ma̎6?' X >vsgBAX4tЬ7b u!ryi EN8&~|n mhkW y{I2;wdj_)Dx>yfR7EJ@ZR&;IoзLSu Cx2FDJR6\YIK$c@̢ZcIsaw^R7}Ec8]%Bf>Yw=I@E|W*C)1o+? !)n'\>c1gJ EDC5a_2S]$)6\=5K ޛERQIox'Z9ٵ#꺪ś1~]STJxV"AeDԏ]mvJvܹ^xʪeZmAPV=iBHN/1aZ鱕\(SuDaت\f Z.B/&H)Ar)]ǍZ*CVI(Q@MjsTo.:s./7i f~NҩMxf')IJ?}~ް3 8Ek@m| v I]ɧ^p=WH:Bi]kPJAEm(DsF ĜC 2,Ul56ݱUʥR͙(Rhz]'8Bc?F1nWSb2`[BQݸq-//hw:Bi0)Tܽia{0R@-2Mjp\t[KMA峧K8ewÕDSGhd!q4y\sM2tPlBAjF(q cvѭ*13T%vp`z0{qrr8pL.a0/嚡cmJ|WTB.Ǝ]Y<(QR &($ #А1$ !yGjR>~1MSƓ٭^}g (4(9bS;'֙:" .\1Hw P 3 ?? P|gTM;/W*PH!xCO q!?YTkp8ygwܝ*Q]H0)%e8^rwCUE#; Y 2cl4[R1$xA@ewZѭ ۵Y9'0KnY$GcOStTt yWBzRDFG.DSU/4U5V([Y Ec&`v8,H) bտwSw;GRʤ6@ ?J!]#G߅/Ovk USQtP`B0T8-vcƫZ.f3OU+WZ3u 4MZr~Ħ)LD(LJG0ĝ0tޤ(w!lln*z֭x1Ur|֭{( pvJrky(A+1 FnUZ (3EKUYt3#jGA>RY2QvY(eC5z~bEXs-y{i^໎#I,R(ZV櫓=Q5UQm˖BQج6R$P=gRʈ (PTu0P$D*֨ ݸr3]#&D߽-s)p.V |\,sԟhI$@]N1| 9.Ӑ-;oȒB~kn|_$$iٖtJr,b$"UQB"4B<"(s %/G]Y x8>Zp]$\֝ƪJX:%Kv%(~EJg0WC$bdeY2׾8=p0h4`}mmWd> 8\YRn/eK}fjVN`lvtCm֏"P.nfp|\/yL H 1 sER+ƍq'~gYvEgϞYtU)1.*Z"3]׫%8sq\ޅߛB.!@ʚ,?XUFmSʎ֙FPw5p„yƟjÐ>F#~ثuS1bJ%^3 ×_~ W_}KnAx҉+bFF"!A&ERSSPIkMIk^k`2-Av*⚽ϸȬ C% 1d?請16N_ ucVֻS`qBntP89셠P/ G^tM,j ,dUW>yJq>ԥۇ$KD{u-qDR4z>]P,So*+\=yD4`R*u]/8N=y;VRVsz^ۆaH,y LE"))Jg;]qw~wݽ}rA<|;/s\>lWMj@ݿ~Q6?]_oqjgwߕgeQ8V$JIdKf ×_~ٲ0._;s>|ϟ;%Dq B%g}zIq0w'^ ٹKߕM( ۻs}U I Ő 9/'Q:h4TҞtR0E@)>Eq$%0N  c?65X*XS~R*.ZZc/;ù`[mKIfx? " kk9~瓙7z@BY(zhaWU+Wܽ{RVx&'4RG3TWޟM-8#\(4$\1T &<ԩ[; 3+k1%;H.M0 Te4WWjgOojd9riI3L1i@ֲ'Mxf[+z*z$ ԤFjR䓗l:yrkmmΟoזAH@ØIB$P@y49hhb.% ~h6 XԼŘSwth^r]Ey`꘦0LurGF&JZ&KI(ϝXEԸ7 b뭊Z6qqȋX֒'{J|TqST%tf{XE :ͭsۭ~j2!ݩA7f\,?ߕͲDS]DI/FqpT jQqPA4 _Z^Ha~cR X 5廀E]FE!a6VN'QT!4'v1'ԏvc7.E z!X+A*J0-✀4\#DtGUXK^ ì:|c2ZCHgb&2wa`\(+8:P<^nB&3gr0 RK~.u]Z#oR8^|޻w}cc6A˓$0J҅sΟ>ycp38!w}: ,/{B.ց)1dnkyl8 b?䎡\/<,ްXyf(뽀 cW? @)8 X4!d>h|@]AN}GN(jj5bq_)$aȤ!J.FԀia8OwbKD~p4*`E1d%s=qH9JܹfRJgW*0hR26KQD{I6`h<;0}wWuKr 4kS.wk :Wj֝;x㳟yK>ƛo>O'SB)0B tC+^۶߅x__ַo~3 C˲(%np+/_?Kg/\P !6֝Y2^KY;G:=Ɠe*b)%)GJ.|)d&K28>)KspFD=)'T2Hv”K}KE 8AU"Jx,Z4 (HaETIJb I)o~n/${;cLyVNV$R?rڝ~ɝL3PCiLh%O'1cʴE9`Zk LVɬf1Nݝd7z0bK6+յJ'Tu8A8WW[gf٩ӧ˥R-H)Y¯=r}̙3'Ozil۾sn Wr?Sh8wٍ͉ۣ 5RTjB UR꺁Rb${;f\21.v!TX}.sc#rWR?Ʒs)CUg"9Ʌ) iŝ[lW)X<4 .T4 O&O@X#Z.w.oMnYĆ^ҕç79L/hO9qUJedN|Rla3!A>܅FG%Bs N, 8pBJ^as] BXT͚}>L i--!7JJTH!Ga) :JA^/Wpق 5jtX2jB`4\,%P Aa,B$Śz q<ƞ[[>gi'e˶yJ̢\4Lz(*HGy2_K鵅 g $SB ]i $ʔwe;Tsz+--4pq=V`o^=?*7-E)뗯 C7{IB.tl6RD}1ygNt_2 76f>7UAE˙W Gh $~U b4b!-zKJaTV|qDym;;;B(Wy0<<lcPJ9٦\oi/?ڋ6~{ғW]N, UH|EA6 Cٗ\srPns_ y J)ݷNx>gK{o2院(yaa"͆s|f̦hSn%(Z4J5wۛFr0s)1ĵ{yEUe"W f_O*RJPTD !dOw-fb\4<0)%;jT;rѴM@ .4r8}th~#-.Q훷%2d\@uj8UUz3{;+͕d+yV_Og@T:fxJN6~ӟFDBh:!/( E)J@h{SϷ ÕmJ߻;}'^}啓ۿϋWnMNY|a6 "95hN͒YRU1j26pP2%n`1346tڬ6Ճ.}=g+%"z}uލl&g30U/]OK0QxTRLsx!ΒXT=3@DTlD:@n3m<r2M]iܛJa}z(2qdð?O/;Iҝ(?6L U-?.I;;Cja5ݱ|-NB>vǗ2dΨK.9/@ 9\@BcPa1w)"=m*7oT\HZ$8RJoܸ麮i}۶/=wfo?UjΝTCO<sL0UZ̒])U]vg{AI8V6Ɣ? E!v b!$+uฎ'CdfZ}pOyrg_3.ڛw6Oљy ѨT3RMkq+Ju*7v{}۶{ݮKSAl6N4*?/V1dnݺ/h4y۷mC}M FSHܻS֌O_K'Oǟ^ ."&dwb/?_];gmy_P*8g+R (E3@J2hh #!eng9\áSeٳI/tu[޳V%۾ùk%w3y1FD?b?ߕ wEGa Vu0 3CUU M4u0WQ@(,xn1fLS4t (]EDDL&nZji5*[s3P,A`&Zp8d@X)$E>d`%H)p_)PB暧Nm) XX&h*TCqjB6mݞL˭j2ouTì^'ͳO}ncgݻ_ ڌk7~SnZ`.T5H8#|W9D  ʘr 2Ï2fs7iν4ˍws^o,;Wǿsp$YLG٥!E{R@5bliD)E&uR)㑔R,:+a\rJ.*B3>؃DXytȟUJI>b( WҪ=Or @wkk餺vz2l*&ia($׾6WV[|Î{o BEyV]ME14R)/.Y0'V a٦spp`4,:=),Lȋe)R Go=HI8hm,[a\y?3nc^>؏s=QMWQGZy ǾNjJK.||W?XnKcgjWt",3{llUT ^8(+usik3Rp9b\﷧ɸ*Hqx.B<'/EABՋd[|(9GvvvfUT5Kww Ţi'{mjX@afS@dFϭ_սy4.rZǫ7 YfLe4T,% .Rws}t3OnXqcG>a%C f$ڏJaߵx]қ352z>['6ǁַ~?^NͿH~N࿈bFc#ǹuQ$_y2\ avV7(,NR*kZ36Ý[=zb}]qΝAB\~\@\8wɩ{AЬVa<4R~`J.Uþ^֓1ܙ\p. c?֪6Hd2YkIQ9 63C G?kӴ&'>=4sݟ =ӪO7-amn]^t EBweS$WTm߃~ wɹKJ+Hٟ7^iU9xػӫzdn)H"Ӟ^i|VknZʆ~{|fdSOn\N\~]$paaͪdZ@K hD0+͢[m܂J[[響zQktwo駞 a )O٦;ڶUMB3rq8 )Q.6aɚ˄$bbPfgJcB@kE#`s{9ϫz__ЮK=jtz?} TnR45E6.|,N"2wS 6`·7oWfIt~15@YxlK<PSeʥl_k]]bO'ȋ~Z!L~)n eEUAQQlf<ߕ,5p}"&Ib u~[9@uhm\\8NZw-Lԥ/o(Rj׏fQwUڹOl>{ FBݬqHZnXDƶ$7onm/}[]c K<Ԯ;;wh6O{~(( :i;kpp⃊ɮ\~]ubXߕĐ-8wʋy5y~sِwfSA- jԙwpa?~\m^OqqnZѣg< w<B%ܟZȤj1dgUjfjgpsvJy}6&Q-mg(ѠhevaoQYYȵgIJ zZ#!ݛ=).2px:L hUEѿk0q*{{Vn?6$sK+WƳx`کz(='dS zI, ƊXC}Ȋr.xt|p~h( j%;Yr1l'4<ש+j5IS J8aK|sxз7oGm4 M?czwA \ (0O\haZ>!:D,OI$[8{BN#( XԪ[Ei*@"߸}(E>*YP0jRѩ%ރbT6g*kwFҹ$썂So`'@ĵrzHVjd>MRpp΄qwf^?`iwcT^Q].].hTw0r8g`2 n[zvj-tJUiTJfuU,Joq{s* fރz,Xq? 5r,qkvuK/xp2XDQTB,;AQ%qvVᾷ}{Y6Ϯ%|胼peoqD'_3 :t¬;jpKm|ud{`K ZꕫCO&B'i"R+-1y\* X^ ,۲$bA> ^7ΦaJ~ 0'O9^^=@9溊np3\_srupa r5I7x#Mӗ>0 o޺=L ǵZm>oFٶK@{}j\)7Y/ۏ)2r1̀3 yA" u`y;YIWQq̉I$qwį>$LS!$!i3i:I\YNdh6"?딣XX )2@$U ,/'DzIA%*C.@)W(A~A-5˚*`cI6N1,^@4@KL柾r0\* :Hv"(ҵ4N90!1`6gٜ!?ƯoR)@(ňyP}#XZбX)_?[[J{wgѣ$IjQ.w]o=G]<6?R _仞cXO]n6[BB%o+R.ǣٍ%vnBn-X]64.w$m]c$I;+|ՃquS_.!dL4'l pLŶe/ZQLy[QK)ZI D Iˎ=Omص,߲)Υ 8r1ŬD6oOAӛ)*)Ĵ.LMBKNIĐBg'NV~?HRӕiM@yfM_պ8% dO^T='#jp? fж4N667~`l6O`vȈכVƛ?m5ۀYe 3gt럾83,.@<]oQJ $ه6SgsՉKx+L&$ 5x^ ZZܕL fIF 0 )E ܜsw|t@eGXHnh7CEkiP (ߩbjv h\+$ 3-)UqLix9oZez q߸p@ KS*ߥ&\JЀ}QpTsegĂw$͟_dsFB8 c L>cF>EV w}V4jȘy:F'⹼b,_nTβ%߃ {}pws0^ӗ%<FQŪRX$!?GI*D-ǹqFs&ID,D" Q= y:ߕMKW_ yB0,N#n\OcaI \WarWvfBXYߕIX^3"j'.cz4L2Xgxrnpi%\z..,w]XGh CSȸV.$I^z֥KTL&u r ȷ=@8$I_RDZOihTU| LDp20@Sę1V][ZO'@^`D0$Z3\8/^έ99|ҏ T~2FѰ4.N48}F!U$,tov`%W\bl.oi$T6 ՝\tǑU"+kZ5GZ}ey98I]ǣA v Ԭ:Y"asFfY[2332c4*gW&sǍܹY}Y)OHv|qbwЏA)VSUZFQg !͹$k9a 5|b|2AC.D}*D\T@wQ;Ȑz!Q![l%y*SCW&J{7ooM҃+nTVo;@̔|UT]E#4^1D BBaW^?˫YJ́('D 4RD<#,IX C; "| 8l^4FTz2].%!1nvCkws)FBߥﭭ;_~xt\f)H!\8?(@aZV6eŸ0 iwgR|F't*0JulCۧ(I\.TD$axo۽^ I_.T=d}9E@1uTQ!1lB3G(FH9[SP?'xYm+n/)L#]3-βu#r8K8+א3ߕ)V\#mj[YߥW<͵َm$}f9 d[+zpwWJ9K?]\e-LH"d2TskqG;[{Wʻs5ٯ A+9$ºd]zt4Z 8R1|R>D\V"{0; {nòJh40lۜ19cRgLd LɃI!QP[,Ξ MG?叽WyƲjroL,\<5 <ټlprV _zc!*wV?ZO5KubZao(9:q eΕMXuil aRbTbΫY Q(swwz0XT J{8El>Ig9!nt:DD@H-Υ83)e,Y,8RNE 3STwsǂ? <9Z8U蘟Y_%:=M[:f#Kgϝ-Wa L| 1hSowk+U"!,ڥ$R2*R-pr97n '!jvI{<)|WݷTf]Bc(2dK` +Ջ+n/o?xxf7{c>]è.u:Νۂ$C6c[ԷXE& Wgy41b= 5&ժWMr;/GyJ[vhV۔ z:6WV;v%叝oی!4{ʉ ?}+\D{n*; $t쮖7S:g;7vGǓh~mǡ`2}+NW?qʇrK<a,##^gI|"d9gW4n9qJRz]?%}035h^ gn>wBP3~u4'{ƚ/Fi߱I 0 "C r۵p-FcٽI ,3 cD7ӨFW㻸oʗ~*p]wu_# Bd_u:*@"`(#]c<Dd[Pp^2ς Dwe jY#"0d:8 KUJ.Zw0~T7|WujbƉɢћ#$ߕ(cw,4sjj~eXopl1-@ Ø16c;TqxwYCgAPi𭭳%lYl:sN}2M-8Nٟ#CX"f/jRMM+Ke;(< ۞L4gwyW^~]1T+>  ]{/KwUh*Ny}[e\rD XI!b󝵺N$Z|j_ixG#&Df$$}ib>>| 1,ʓٌHR @YrNFrs%qq ӄnAl8AX"y_./_K83 p{~xpwHm`^oO֭ru:|vFkkkݻդ~Q$ѵ\ aQ=ZZj.K`qJuŋmyo+NU3D"$Wo!d<$lg_o|wΝȯ$R]{$ϬVwA0ل~n."h+jݷ.22Nbv:{F+Hbl@p-qx0O8MBߕ&)qFci;tj5!N,V֯<}bm6RVuyA۝f|Wf=օg cQMY@].៿b1FdQm̓8T*m$iLmH$P,@DZ__Ϸw›3Bxלr iW"MB8nJY<%x]0 G.]JLV%gavnw^_ٖj{\&UYP;T@0 O3woKch^|zV8"1ĒU"]2mo~˲tw4nmm!|>h4*fɶ!{y#/>[%sNٺrJ I!޻2]ZWwυQliǓ}ʾUyZq=>6Wu2fA$Y_oTk鄱+ /ovX歹?x}(VQ|ҹGQGTyzӅHe/>_ѥr+6'nwJZWVB?.u8V._c_}[?ME"8 C^k/{<Ξ9W_||K!E,ÒU֧>ҿz̲WV_fg)ۜE@3!1ɓ.EẑސHqZ:G’܍z[e˂!0d L&2#۲`wʼnXx*-ԻS|mmvM7Eo,Ue^w{dR=x]بl6[-u Q"wvd;`@/jl~ԙ|',* D}wqixMIٱyq{#kkkٴn[\غp:olgZܲX9̙;ַ.2n)/? c*[2r-RǏ^\w9H­6!|<>)ET.ioƸ纪 V`ڨ58Am9#Ј=.tfq^>P: #kiZp7gk~ʅl!+H2~ce? ѠTjW9y|WuZeGA*dTvm-&FvZJƵ3ok/8YHOZ=*j-pAms' oD FiYbluyyom|.z>s^EN"9X|3W?mewe5 gno<.bBJT d$MjVb!v|_*ō=:Ox= +I$ϓMyx};wweDb@Υ38M-q'$]ǽ;8AҊc9 g(DD!YIw@=oY 1v0[6c.D6yCbę䑑DB>!x|m߻'XYn ^q\7MyZ˵Y ϸq|Yv٬ R)ixQՂSާ]y2͒y$*[zn|WRͷݻ7˓զDWjCDBdFDB1U wew!>ޓ^W!&KΜ~=J4n-b'9@O#r$DTd Owڮ[B@K{<[bp@/,]{vtڽ|߽r>)"̒y($BuO}F=D0' ۽$̢t mRw]hB,8ڒ$CR$2%])e.i.x^N]? %{%18k/$ay.C!r~Ckrw(|Y!?DXJ7|) x9~!|Wwz+[.H }~}$˄q "0N;Ƴ>;}߿~:szkw ̓1yGTn2Fz3ڼUr@<(@zQ/(tAӛW>2N?KlW^y{i џ[(_#- 뾝aԼ~#I7~0vv;ڣ Lc]:Gߕ, TV|>|5͋`yaT`ľc1}k6Oso,V-و셗~=O䕈']d9~K!ͮ)]gHDM{8"\ ~ RcN)E*[YwBK' kya@*& LaR1>%b0gsA~,]UJ900%~/>=>Ǿ_={ғ.ι\]pO%"JQ b\Mv d+rƘ^G,"G;RSfIꀊ_.Qo|VA͹"p^Yz@h?"Ole&IKd8򥯄/RC/z\?yfR\|ѱIYLTg CPy1J$yV=KQ?Ab" (I]z@F2V#JNeH3y(B'\)hLD?r<̇?x]jy]d gtZ֑v Kg8Ϙt(a7:~$K#"TpUYŵ2KkNY@/<(&0u2$VwH[&45Y%Dd'.dų2BN E+;,bH]ϐjwm )$<-|^*9oVV$thE|uJ!VA=|j\YnW?*ߥg{Lx|g eJ KDѤJ/sF7qQ8Gfz#XȬh8ej(ކԢhfBFFwT27:H?( Z|N 3^sCҌTo"iA͐r-)S 8P (GV P*(t̊<*!!<R(4DzJGm(F܋DH: S*?Dc)%%aKeUC+Z;8WJ Oow'\bQܟucq RJ+K",jx &Ռ9E<ҌEy~.j),\K0S, w)]@)NOA@aaLI.Ig<30fBBGQ8IV{'%GY(5C|@1_2* *+^) )YL$MdEڶuzp2'Zf8i՚ĐS#o)Y.V5O4jQh'\H-T4* vWʉ/md,DĒg-],`WvSVda` @UkvҦ.lVL\͊o^o*C)Pm Z %UvB#0$ H|/!X?Ƚ +*Oz$EP*hE۠7$ Bџ2[]-{xv`]œ} t]Heem e31~IA * k!bֲU!=\>u?DRFz-Vg*# 2:ĐZt %%Ȃ "m ( URuC@qC[PrR!ڪo.+ĸjS:\kaF?aߡPʍ* 3]T´Q;ݟE"Uy9veȁN͵R c~daBMPlLBDAa"*{jS烐ZwB.4ty4W s9O8f`@ѧYyҝ%$NZAYT(B²t*"2+7-: s%B6 UbB욏UQ{)=ÂmyNP,9IWҷ/J[ÔtsC"mHjL̈́ghe+Zh-xQeY<BJoO3PBF{EGx3t/,HJΘEځ4|2!c 0F#hJl bb9w45Ղ.Xd6PLrnh*g'$}dHJ!9~\ O$Mq]'y@RJ)έ&߅g5G.Kr1EL~/RJ$irOs^2?o;;ϮnW>> p[stjIDwno]ҷzu_}n?,̨Cf{s\}h}B3^ͿyYϦ;?<^C- EпypbPR߅6ɼ'"g8_7ߥU '`NvF` ĩZe2_"'JAoqnqrl  NYT Z' j.LjXތvܮThwKg.\yt&"&I8ng42]ןz#d6o|vǖԚpWhsw~W aNZ$F{ix a{UƘH3J p(1DS  3(^;?I28g9 q‰1$s>;yʼnUK,v#I(I$KG/|ldIPg"hdXd`!x JA gx7.ܵ8$}2F1;1J6)6+%5 S2.-ȬM9W'\P""#z4u18c,Ysqҥ`צ sNLy)>.h5Ņ6bPJ'AwcـHϬ= Oxp,6Z O/MOc&\Np 8Kb-Иs v1;OU\Zuz/\zOCwI\0xi]IEO>'}-D,i\C0'bZϨ-wG) MNja_ };{zT:E<9Qitcz.'~N0?,\ ʽӼ.{wBZCΟUca >5REevԥPǮ-6UHqf:-{0 ؠS̿jZ!ik]!̆&űH+*j֒CDUm a3zD-qqi DJZD] fX2&f"{:wi/sFhhqɜQ3'.*af,-'nZpWhx/NF»I<0]DWj:)2rA㏢- Yc&%0r߂RkAQ̡- Ii=ZޛIr\㎼שׁ@8((Pĕvvd6_;1he2ΚvfHZI $h4꫎;#*#="2QGU=5 0 ~ac[.Lv7(ܮl!H&M(yQ";A+ $<{3EHͦԀob8Τu[` 0fC٬ % @6%+B̀{&_d6is̆CfLP̢.%|LHHiPkj'X59ܕyo-0d`NO6=Ҥ(zεXYB^f#AɏؕYsNKKEWf쬠:Kˉ@?_%htXJR#i ˲RAnW["{v>Rd2LXSg;Cj6&G&of[΋>zZGå}g珿ㅒj4][}RLQ P(f庲ov@f A?:܄N;(RIɉ3 {o1wJ'R/Z_^ wVk֍{Հn׎M8ZܬO̕qz<*n5珸jC/1g\j?NzaqVw'\o\/ ^neX'o~Fd>Z~^ խiG/菙{SS|.tb%)/_K]Y,r}iz9G٬ˊ, UoH/cfwgfw>%;6ڽo4hlIRT:vZ\"ժARu^w2!/8Sw7?ZHdƝ]~"Od 5!p}j uF#o4)v6M_}~u_nSW^b$ q?8k[OuS@)"դ 'Ikώ:>Z?xJ.[$/{co7 ŭT !JF/?J_4n~a(޿;ZL~O\N!exO؂D:9,  bi0{ͳ3˷KW+aAxDsYn|Lq vn6zu޹UU+9`iyUgZ^O "д2۬@MEe?|mS܅~bx*uϞt}Tynyny{~e B? ?( j>Zҏ.)+HAQzV߻](Dw?xhwN;\Ibt^5SyH .wVU~|Χ=daQcw}̋V WB 4msJeX h M5jYXX0 r[J< >lZ@BBGdEkU pOG!-VeM;0_kiNzL[p/T$}N$Y)eT' C6MMvGip:Z2ʖF[5czؿ/rVRpqzKҞ8q9IgZS zdq2NDݑŪ̱T$MRo*NxF[ehh29$bLdn3YFNNGr]:RMx!`1"]`$qd>cnh=}7ur]*b̦Яpx'?ߵo8z<*Z SX߬:/,ͭ|^OӿDyHsl8]`o2& $~,Ng| ;'ML_Lol[Qc8sgSS?f zkDnІ2*3Srx c @]IY, $΄&W-9[uOHABvԨ_,z~5?@>dw$#RI2GȘ":KFH2Lwjj(32#f@a gb]&i`d[A;<%l>lQL0-̑^CX)aa 6{ s`?tqY͚00^i 4l]6Ce0l1QnPb !AM=`lwA]y507X_|wAd42eev6ouΛY&Ꚋt#ۃ"#dWL<e|WHR6== K?ܨl6<*쌎gˉDYKO,,1]\y?/Ee#oI4]VKeEeziiffb}Ū! O{t滬 ]7ntTk6;cg|F4fˋ~ѱb=6b! z77S8Y|^kc#968!0T-9+j'8a|8P7, ǎMxl},[]v^'Pʝ\6vw~\ߺ~N&7jF2Yd~W_y${t4МBYd!`+yZy ] kǎMST*FFBC28(sȄ,ƬkEz6l.a $Ii:##JQ(T~Xd~~zeeG(*ϳswf&6=="I$Q(8Y8l\C/푌oy}>EvԨ_}(|:365{XdkB&,5l P;`pJHI %0-ba{;=99La˲.B|0⤱3pր!ay&LfH L؃kL,B02 Iܓ5& C(" HonEn^Gbaq,6džJLdy2&0#}Hŀߟ,B˲ҍd[,jssAX h!|W.VlA#2T4M-/{w^o '&:ZQ*#$;;⪪V mb8 msg唰؆?.O$rds*U(jG^]ygzduo6X\j6E@nnnlqq{k+珬Ee魭n < k_LVk..n?̼!Cs8wz|WfKn{'aבaHU_4X "D`"\ciGAicKCEJ]ze# gNGfY!J4UXVhYTUeExKlaX,3gw-}@g!<#;%ӆf0?;|MP; E14Ͱl/8+>.|ava!p.t]feEeYch:,4壅^!@,c#GeUUƃ> 31_mZLN0EeJ-hBŋO>%>`ГJmil,p>K?AJD}t:MS#fS RgO$f08Y9%,,!fO3:b fQMC>& J $4IB.]8F߯_0wj&SVÉDnmmp#,E|>_Y[K$9:/u%F҉Vl⮗&EaCw-(Lk"FO#+2+}]D62I B[ VtǏONܹj:~|" b-Ѱ,sscsw7/[C4M=ıthW$|iMBv]TlVZ2Užl3?w<. |Wk ( %yZ tdcl؁[m:w &̚S)Hmjg2.A0Vz{(=w!ؔ~<\VbN 0v=Kf7Tw&w00oJ=0[ww=HV";jԯOq@v9|DX;vl|uu7LO7L42( c\(TXTdgENF0^㸾d:]|SFb6[.Ґ|WX{ck_3Sߣ+˕C!o*U$鱱Kå'&77Z ^|KQNGv:ٔD"]F%а:1~heY}p& ]@=LOj6&Gљx6TtDՃ۱-/("&LRoO2ԓ}ub楷n-eYA0iEC$ϘkqOO-R~hf `{P-. r`'PYaZ>`c!/:t@.,dDjEg0RFad+zL0ޚD& Tkl,rp0vOphNQèW%fgGIZY4FG##et{+Y]=g}O1ߵ=wno/xv t66Gu~κ\b4y67SѨVVsϳDnl,bāfu" A.k^@&n,!3Z&jub ܑť O;ez (Ǩ[Ha腅ggVWwwwѣcTD6e2[[xwf!EʃMUy/*y맓dh@zy&~$ .z|{asX wO& F gxKΑK_Vܘ#n/a/kF _|"R7D=;`h1u1dZ& "KDdys|݊|dwu[IRA͘=Y#󩖮 3X5fhF݂?C].l"{wfnZ=?~#i߳ v-U0ԉI׿? Udh=%3ya_CO {s:w}jwhEҭLJ3>$U O'ϋyM?&.S莀0Z03ɴ~.W. B]z3Ϟ٬5Z4r].й9w >"m_n4ZK:'\~ni,Vyzf+OeI਎BFz޼^<}s1B'^0v2fn'ȶlZn)_, Q+uEw>l\lYP&? G=>Zѓ->|&%v#}y'3;|R/>yj/^`߸^ p!HV{Pѣz`l[QWOMƜ؆`9еKXX(]Zm* Rp!ndhzbUy~l7_gwn;zKjKNbr 4ZO4߼^].)wyU+'۪K5 _WmuTM;,$ ~X'÷k6jA );?M˭cΏ+/}>J52 9`#,c~]9wݩ7t|WG~ȈxtquϞ[԰s3 m芁WQOh udm(Yhx< ܄-KB{O]z XslFnVN:͐cӧ| k_~*)Ia!ntĐ+I0ϴ#>NQq|୍ڗ?ԕh[a'ȶu!?~CzNLno:s1Ū Aܘ%1/?8b7MyfrGN&QG( ThG%E!)dĤ+\"KO"99t^ew':]>r֩Gd'24;j'Kǁpc+QoӔ1_lIq?sm AOv_t;oJb־Q d2etޖɚK .xАc!4rY0G#2vR25h&cYmlbΡ9}I>xaL;,//u:wygdd\.OMMy< `c4yEQB4MKxxZN&X, h4wnléklyyyll,J@XOf\V~>-vu@ K(ҩ{]X\ܹ\gf(|X,L&~,pRH$~ <˲Ej5A0ƕJ%Z- ,4L&5MbO<ĝ;wΞ=[,^/I!eFHD(qV(VVa8Av*ű,iMQn5gk5z~jMcpUE.MG'lѣ|~hhpeH$)f4Mx`$2d@\ǓdBPP|@EqO&>rH,3UL&3>>bd_w w1@Q(kϲܤ(&,9rn_|T*]pP(3 aenlO$GG:[oKKDBTOCKKXZǎ!I$:wFllNp㝉 ac#Y*NO>t:(bݻJ{9v\oٳg t ֖.=k׮=cc0fjyy9 BVڵk>,Z655EQ[m߭]f^A@gOC/˞Dz]}$Irsܕ+WVU(BP$H$yo4jn޼t:WWWr677s\vcN_uVU4($v3G  Νs~Q^Zj=*Z^3P(z<uWԔ##|"!@0ّ$ 677CЭ[`yyZ Z-HlooͭZ ~1i {\.'c=fL7'OLӊ[~7ߌFz"OO?u:[I'C_I}ufPrgt(2ap8 T*Q٬a;%`+^/++Q 06Ƌ"-T  q3?p8(3q;9/-5[۝lVYUH-.e^ b>xvX:35M].CP:gYm}tzW˲S ) L J,03ݽ:  E\0Z-ZL(LQPҁhЧNkzh4L&Ƿ;JRr\,ժc4jHA;~&JNL B3F8:j9r0# ;9-w$"rT/..~+_Y^^zv{fff}}n={vggl VE;wfffRTPOU0+ 4b811 KnZ-V0QT77 qXUAQPC KC&E\y-Qyu17f@@jϧ5MVj<ϝ;w`ssjEQ^V Fn<:x\U^xacctJK? \Z.0taaݻ c=fy=wnsЊ5ZjE_P [c y]%`/BN^x< 㼰lEQ,Vj{4u _sHӴx\GbMs}zʉbgb^$JM Ѡv;')Ti&,hTn<:.812I%+Vp\@|x\H$ƪ~?EQ~]7l6 Zf;(=+ˁ@ L^x((Dh4TFЫ)@I$$[ʉi֜NZ\14eeZMENGrY'%Il\jzKR8IgoÆ-ND"4-ݼJ]w:g,N*u}h~0W(9}|_s2yMW0K @xI--mz4gWO%YoKt߾p^T dԩST* ]v:ujkk+鱱o߾===}ҥӧO4G x< j5դq&ԩS}ޞtciih4 aЅ Mj'&q꣣PULvNzc=5%8+|{ !b._~K(,..nooߟ4Mᅅ4V꫿[E ҥw''Olmm`0=??Yp-׫ol"؊_?7nrvn\ŋW^}CǖdcwI}^I6R},r= "(;e[~rY˗/1}Gio}7o[nB!/_\.:N,?-bYeFqI=1N8###NgjjJ?bY\z{mH~B%N'GGtZ*r`tl,J'OR5MJݻG +++@@x L: lrItҥ'O.//'۷o_fo߾b1v=22qΝJ2<<|ƍr|].r*2,#?,+ͨ0{3>"$A̸,gldAwo%oK/y晵h4xzNܹsieّӧO_t)}:HLOO|_~~\.OdY… ،_r4|@?:<'nN:]GI(Vbt(j  HQHT*`PN$mIbC\@g }w:dgҧ ].$O_ES .WݖȼH_E&?0:6|Epڵg6˗/{drww7ϟ8qt~nFeY B,V522$)VKF![i6]>cE٤dtIp"[,OrV0lҊT4!E|].٤A)Na0D"`0/vXvWWWܹp8x8p;H$zzNyaaAqnk611q5M8wvv)p}޽x<1^\\TEp8\(Eؐ$Ibiiɘ2W''2Vp![TRceEƈܯo!i֛ S=e/z}XWqOEqttT?h=55G|333U355FWWW(X,VVO>-r0`'ieh%_D$__ipաáv<U?3<9%IpX*=+. Nv0izdd^\fj(`0.~nРZ-IQynIL K^+d273'U*m8a<؇`A[`NñE_刦_1([9sj}V/^Ny^O^>"z(kn; ?駟VE'&&H&]__㒄'^mMO {{I sx ^[k"57'V*Tj"9q‘RoQ1F;:,huu옃Q8N\Rs8(YZj;\]mQ d{{̙3>,ܻw/?,ˮlnnNLL_|8wuj?~< gϞszR?l@zcAollsKK%N' Q D$H<ib(вGi/Ap(f|CG?#Z:_ ku htrrR.X,+;$IO=˗www=o|_?/.///ɥB!xv[J-TIٗ_.(ΝsRF{vV(RIv:ZMn q~?y{$9uNv>!LkmB!)L&/^x#Hf23d˗d2T*˥_!777B ҁ0 CӴ>B_eZF[n=/_^___5á=eQN:@ξ}cQ;F>vІ٘{]tk{{'T*<Ϗ9sΝ;'On󭭭:P(O~_~_ gϞ}w;vs}}}rr͛F@`ht<?w\:=s֖w^( ;;;ƽ'H>"t:;V q\. ;r"Ϝ9s-iZS9ri'NSIN"Ky]i;1vCŀq!looONN?v!ds2f**E!A7rѝF114>=Z, =8R8i vA#Ϗ<@`fPVAJ?9ߵ>,\dXW}H{F3 B?#߻{Sy^$-jsAPTMgF^\.^X@DQeҞMkHVSwiC4 *`PUՅt:=77gkJ;w6778 6H$j[}>_^A?rld}*:08 D087fHD*XYFǎ)wz4Ml@jx=A[پ\fΝ+mn{$Rޞ'~~*<ϧǏSE8Barr";(*7onLOOP>Ezy^n`gEfۙlbYb姙2mH(G?j^YYF^ y~ttΝ;n[̙3lVoDžJrzjuuP(pW(fffBmÛ(jf$)@٬:348m^U hN_IBDv{$hPGRyTbi;kTK_- 3LD"/ׯd2Riff&ꛄV[ddY[[|W^xZMOs z2_fΘJh(4gfm,#[$tNJM .%N \oDHwv+LW!(ʘ ~}U`yjl~$ ǗeBfC{L?QQlQ_}w@JOtA4lAgg[{!(g<~" ]gr^  ai$ VUڵkoƓ'O~fp\.dYܼyF|X ahUTaHS;K%9t 2IKT\NN$ yyni Aw\NBͦЭit:ie*:>>bnFVz(ͦ7[ͅ/Qahm܆n,{6 BbM'bb#x@$\a\+e{ ػmK9Q#FEvD gh?\.}UU(J?88XYYA>AHRRivv빱͛7A@ZJ>ub,˚Ml8u5j5=#0 AuŋEH)ˆ NGBQC1tqr"\(C:>}g?;\XpI׮qV\)IR:::V.+͢wNNNX[[+ZA Hf\rxx0LV3337o޴X,.--ݺu룏>^n޽0 rt #A8 (Jdy] BhtqqO?EoujJ-۷nRtzuu`mmΝ;GGGϟ?o4㼂lllȲvvvDQf~?|>j^ꫯ.ǃŭIs&fC"xg,C>(?y`)U!`FL޽hhlPp8E<G#:rq0;;{|| =(FL&CY"(($IKKKFCEd2Fr=|*Zhii&@gWov 4 e٠(xv*۹ܕ7p<;,] Qb N'ŔeP(jFp8ѭ8$z=tg=gd*a0L&ApZd2'''@vD2H\^#VeYAPP.8P0Ѓ6Ry61 w Eﺤ"ʣ(ݝ}ġWedA  t@GG={-àx`cN ڤzq@@z:GN0iH!l E & M%e`8WxLE1s9\uwfЫh `>.ylJxuˈ\΀EYQ$NݦN#4A0x~wbuQ$D7Z-Z01ۭ)%&I)niF A2!;1O ʷǣIPU}n {y3|Qhژiިp= y!rjz"@SUv7'g0:V0c^2$l݄c~Iً*)`<04`0b< Cߚć^`ydY`"Ϟ=-J9??svZVr@?NFnMWy x\q:+?iχnmm7O:z tn ={655U.嵵5]_xH$lXT*X?A\yP(Htzz( ˲X0~lqJhwޘ+\n0fR.1dw^%lLh{#+`pOhRA 8^ ^?4hWvсť%˅9*j& ~ LӔe9핕d2v[c4t:'#XV+Y5tR jg˥Ӵɲ׫:+gݺۭzXL:>vȍr$rɨ*\Z)42\.MhjJ,OEQRTJ$Nb1 <|rݵZ 9f$voyyrE=uV5;; }>MөT l<ʲ^r99;;+B$AD3 _^o qQ~<dRA]|0}>Bp$I14Y:: 3@<!oC0هgg Ta|WW=Pi/IA\foT |=Z^v ~ۻ(Q|UvO r}꺎uݺo{yOH5сBaw 1!BTZFdt$i&Aju=~м2ǔK]7 ì՞%oud)`}tX6d5U#8(gH9&_[@vቴJ϶EQ|sssz z ޽{7ۿqnzt4/8褺@T*q/\as9#n0^8=BAv W˩x}떻PIFt%ūW9~v @|r}*xQٌBannP(,//?}G?Q4}YPXNӅB?1Y7G~'оǧ~[[[,|[*x'eٵ[nq>bxFz>~ mkƲ,ph\ӿ129Lz`aR>S"Ou:P/,[[[nݲz0і5mڅ &8@PU`+?h1c^ >H۝I2OEr??n7 H9AE^qaD˗T*JyO㸹9QܹH$(_}ix4mqq4m??Qh&øH*- OuIוNVy., VDU?PA-hFʲu BH*4\83Ww!M^/GQ,Ke'4TUSQ>_~FMN0fW^Rx 4M* ^AB>4MN$jKNQt0B`&z!jt:}rr 0+R{$XX*9hڌ]$i:<;c ݦD\YQ^J k (܏et(rN4Y֨V)^zK9<, ?h?ZE:4VŎ|M"+U*a&(`vvֺ`7^kÀ{i2 N%IB,"A(9iEi2X]`PlBfcahF|2l8a Rk"f @(02k/V>OevX(*99F\}/ $I.,,looJT*{\\\T*d&-R0 @X8NԛH( czim*Ѩ(DK9 :,kJ0.ȏ!fBxvv>} BzAe}j0 Bh@J%43ij5-"0nZ"ߧb@ Yu4x2zӧ9NI2u>CVB0==dwl-ID4Xϛ}^DT[Ra ggiNruKT* ϓ&Iaê<"v^wzz:6`0H$B#.kff)DMezL&p8,2 Aiq\ZEW---΢jy21q">ᑉՀY%) #9u\Y$I$Ir].$?U$ Iv-{R"H8F,?<#󯿍Ͳ.o.[zq.tZm7vW( i_1L$@QF,&` ւ́4̇ch%ZWH&\]H\n[I(QT,kW6'cٜg  & 8m-I#-L2Xƛaà3OMC?F[o{]{ T|w4!Σc+3.Lbp  qe8= u(NJ ><m7GOJcA v9m JdQ-C0 0@յZՀJjkyE4PU]Uu0EuC5T4on&Vӄʲj$4n t@+4u__ʆQ h<a꺡芢j(atEѰMU=OږEMӱڻ29أ9:8p> q0: - X1ž8d0*v禒Q!>Y6ei0Szx:0 4UUMH}v C&ʕ+ӊRǏRډD++N(j*)kX`f&vxxZw4M<÷77ׯg^8 I"=xz_l[Pmaf&͞ pk(\2]w*}u z$I1 vjA(_b?}w߿L>|ӟ!͹\ZxAe5DQ$jxTj 2SHxͥnW>Vxדߗ8yzXj7ṋݒR<:9)ݜ$SqhpЭV%Uơ|_xE&ys!=8n7˒${<\սre{M^׍Hok7 ` y z<4AvD"UZKK3''n֭ki@}n_:0T'd2Fo'2 bZ{AD05Mw:~_-b-gSSF_ZEUVwMg$EQ播Vu5#J)F.TjA@7bjk( RBsɡW<_ Cfř4@ljňxx28uqTEUєUa`8u`ˆŗaM(Xc 6@-#mYV!:ꃛLA$e\UU I7]HeRʲ0;?TA,+ v!YQTH PaA)*Шaf7>:Eg?kdq!>#.0MS˹;"]Ri(ϟ)Z?~߂3b*8`i2[8|ytbw`3mMy%#'QmB3DFhAӁ~Dik0̅)ϿtOv[hh4nw??X^N+lV/_EqcEU-bdhFH[-ak( C+WfN tʲi:MZ.&@4}YVi4 x4A6[B39wvNVV2T`iF__/3 NǶzkYUU(\(ԐC^V'?;{oe۶%Dd+hӔʕ0cTvvrssB,Jk h6y@$}`4IDa0x  Jkj*|9 H"D(w3~{f&JELEߗsVkn0:IT*N‡% $Iv:d`L"| @&8|V }\6[(o^XU*D"47>t:iMhz]h r%vF("F"BUf<ٝ-/!4M3c39ش[[A m qҘ ɪ:cs$@|0%<\cB]ȱQ7W)&=b@%].""viFH`Vo 7ǹ~"I ptz|g`Ė 3]p]VՖA5GY5NwAK0Z 9.kA<?$4HAL##֒$nİ5^8Ps}v |\'Ov}>w-i*,h;KU z+֋H][ۏF''@{tT>8(RnW<:* gdN=Jj'{=)-u:IBvϏf..dY{ddEbƲzѦ,kPy2FOq}/4u=R#\ݪTPDzssɥGݾi/pǃn!*Evs߻wdH4uB2ƛOL'/[c.]D|H Dh shc,13OCK搩mq4 50 дژ+A"9xZ}zTsSpBxlp0+Fo6`гlnftfAl72n7!IѨrfwo޼9)2AKKӨ) ǃsw:D(rX֎ǃ pt:*F(;.Q+R;,+ЏC5sy+یㆬA|d2}#ɐ&0Pưg?YfJ:ԅqyrK(c 2KZ%IPwI#\@yEIt7^+HJ3C~2OOϦRH'a9b;_OOkTݹ߅߅E1B endstream endobj 222 0 obj << /Type /Annot /Subtype /Link /A 223 0 R /Border [0 0 0] /H /I /Rect [ 233.2425 338.1166 244.0845 348.0372 ] >> endobj 223 0 obj << /Type /Action >> endobj 224 0 obj << /Type /Annot /Subtype /Link /A 225 0 R /Border [0 0 0] /H /I /Rect [ 244.0845 338.1166 254.9265 348.0372 ] >> endobj 225 0 obj << /Type /Action >> endobj 226 0 obj << /Type /Annot /Subtype /Link /A 227 0 R /Border [0 0 0] /H /I /Rect [ 254.9265 338.1166 271.1895 348.0372 ] >> endobj 227 0 obj << /Type /Action >> endobj 228 0 obj << /Type /Annot /Subtype /Link /A 229 0 R /Border [0 0 0] /H /I /Rect [ 271.1895 338.1166 287.4525 348.0372 ] >> endobj 229 0 obj << /Type /Action >> endobj 230 0 obj << /Type /Annot /Subtype /Link /A 231 0 R /Border [0 0 0] /H /I /Rect [ 287.4525 338.1166 303.7155 348.0372 ] >> endobj 231 0 obj << /Type /Action >> endobj 232 0 obj << /Type /Annot /Subtype /Link /A 233 0 R /Border [0 0 0] /H /I /Rect [ 303.7155 338.1166 319.9785 348.0372 ] >> endobj 233 0 obj << /Type /Action >> endobj 234 0 obj << /Type /Annot /Subtype /Link /A 235 0 R /Border [0 0 0] /H /I /Rect [ 319.9785 338.1166 336.2415 348.0372 ] >> endobj 235 0 obj << /Type /Action >> endobj 236 0 obj << /Type /XObject /Subtype /Image /Width 269 /Height 300 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 269 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 554>> stream x1 0 =ll ּFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnFQnF]C endstream endobj 237 0 obj << /Type /XObject /Subtype /Image /Width 269 /Height 300 /SMask 236 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 269 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 79640>> stream xgu zNUu9͝ r"@)ʒ%ɲaע-{VrxWZ[dKkZVXI%YH `fЩ}oߞ;~~?\7ӷԩϩ;BD74" t q~h^v I} Aw2o|{kv7t nAg!@I 'ZgZ Ǽk]eC^ /6ՅɆ b>;!kY3Ej$ P˲jumyX`"Mz\_jOwې%䫁ڐgwչ~i/ykjmCv:AeCi= ïKL_rnv=Y+Abk _5ěbw{ߟ} >8>{W|ǿ ?c_|Чܟ-?=oRL@;O}>~{ګ n.__>|=/~{/BDOxwnr>X5}s+?G_~_xB^?ȗo?w[O.2^k끇m(IWH'5\ ]݆4y%ЈH bR/eSuԡ]m*??ve/~Yihg&TS>3ߖG>yc/]7=co~u=s.ێղ'~]#}}kmϖk͏B?q'#{GώϽ G'm3s3s"8~fs>uS~O~K3K9Po,]}S_}MVw?{MN]᜽7E+f;>79yWuPoƧ~ݸΛ'?ǿ~@Юc<Oo/k~'k7g $WG^GO}_y^kZu q+/疯^9$ C[ߟahHV߹wzO?o,u߷cOƩ_?3}/~kx뾷Gzs}"4/?z|)xb?◾/^?^^^(~s=܅wox>-%+~\/B壟x|f{* lv`M~|l >msRs.~꫏}SvlJ"ũſ#3˷ܟ2pԏ&f?^{'돽o'ѫ툚='j婓oڣ'Z{/=Z?mo|)]?>g<)OG/M-"z|\=._o>^m` wYWx5_J`n{wZ#"\?KKN_2ݑ]7z<ܛI;8Go?|DG9c=JWuXE/< me2=;-'`]=#=6)h.Y _-D pnC46ի}\?|խGjxn _ \ȯر鍷^75o?y}YyQ]ooz-Jr~xM/xݶ86Z}gNO_?<'/̯oٿ[N?őܾmϟ2vey@OM~v0>wQsϖ}M]+DO: c}k\)y^G_~pR֭ݸ•]$cûG鷿O.o=md wf|ԥmpeqd w+yW9xpN\TD+z3G ]v ?}jo޴ɾ\w̯a=o"'0Źҿ=SKWADڵűl۔?uiv;_w3G^x-1+5o;23ocK-w#/^ڿ}uۇ 릟?n`6^vz}/|',L/a}s7\† bC<q@T1J7~kp}{!p?НWrq | Dp~#_;~m]=Ǫu7?\Pa#Ֆ_X:-o \vF",GXLѓO~if7> O}@H_:"(/kp0oBl=v;qGߍv0;nRB xxFD;j@Nd}6A[Ba{Coͯ:Qx]]SBxl}B !mG8L$Z ģ+0CkF`ˮٻxf`c.D@x  \\BPjϟbO)$B˂sPhM6=  5gmCEg,,,AP^]e`"4i %= @&QmYlQ^D$%$F8ʕʊ0gX-.~BAWW6;$CX@[&,C6ك-PyAk`/6jz%m=0>m m<m+آg-ː"fKKNC6.mc,&W*P T =)yشJ%ܺN;@"8v FF`fi ǁ!abP|ls9Cׅtb1ںX])tHielJpq\/_|*fP#G 텩)ؼu@DMn,j8="siPFerB<ժز;\yemf&rMDB>l:~p NLF"RZZ2deM⢑NQ0qgg׼fնٕ+UsZ\4.TyC[g!@K!ҙz܇7t儷w;n3 m $j +|GF9@$!ѠsѶM,s\[]d+A4mŠT"@L j@ss@(&m  5pd{- V,?5 %.tv<9vmHF"BlDzH$׊D$@nj1wW.^`,Z<1J3!0Fy?d BU:@RD/mI5NnX^[j,06a A7wpo{ щh|пÕuY\,g7"ǚ"4 y~˥Lxc{Y }}%t-sC9=DdOt^jҥe?B~aח jN~5|W3c3nC]^zvl$3:_ ݮ5݈ 8lPjbX{}%a-U;Ǯ+,0$HXE a:tA/OdF$kGFr :sKOVJc njgؗ0 W"t$f[++ZSn Rb& pƗjח1 &Wke/cR9jIEJѾtҜ4&#㦦 HGJ,lvKFǥ}h|>עХr}v mnv 5t^Uɴ"T*F32&'I\n֛XmE4&]L f USGd \%Г|KRgr3-?Pf}O)OZwܺ#{&"ufRn;Hr/. DRҒETTIFz bU"gs(}ª}01Vs|DD"Ű3S";$Ɨju+֝ބSڑ .,TTBlY|g|k.8X99r-O͔V*mM{frudEMz?66sQ!@q-oM;A"#aw~cܡ gp=ͺ:׆I|{or2??zn<ܻn%&#ZO4mθҡ-٦+͙.X<*6db3SvSjj=yie7SS+LHo/iB\*-5w"yX)3ZTb=#=z~(iDua>M I"خ$5]yllf{Smz66gc Ox֔bCK j9l\ŌY9SHp5וd{uJũYޡaMp1sޟaN6>'͘ : ǝ-XSHڀ}]lWj e ;v͗HRZC陿䗶mnI$ʮWϚOׁǏ|kј|=w׎5^:=x-lLD-/LTGݷuK&%@۲*".-[t.X왭Omnz `n Ӑ+V"HivgyR*RlpM70m;z=7˫5'f\Ƌu熑\`@PjNEuᑊxDdrPɹٹҡ99/T.J¶jEႳΑt:F[kwR{rlWS6d}G}Bt+A ?.,nٙUjjQ:'5Ǎ$M <7:Ұ]HMԕãT_ԑ#"nC`щ 3Qqm;v=yaRdO8쮻cǎi~Y\\x<^(3OR޽ԩS{9wΝ;=ϫjx|zzz>&_җ!O>uԛ&0McJH$JnϧRbrl&v?Ng MIl]j.XуY uF73ĘozRg%J: "s@JIEC .tj={t_ZZzki?77Ɓ:泰Dvn"""3o&rI=5Ǜ[r[LLә9,[6?HoGjqL42d@)%(c0]bD8_6//׷qk":gp\]~Q1T\E}q _ A*549B=ٙlDEt0wc*::8]̸=r!Í&JE*?C( z %!٬NܵQ" dlٔ:,FV^ƻ=F=JIOJ55]:> hj\yxgLI-gD5˵|R4M6ktu4V۷oO$X,T\.NQd2W\ᜧR|>ﺮyLjse2D"^hb|>ZTJUu7'_=p@6go9%Il1u| "jZtGrwb``j("ڞ 9",լs兢k!qJH"JcuRD Pz$RRs83WԽpwN4]3lEyd\Š :{y; j k˖4K)q]*4\F{cKeZwe- 97lM1Y5Y';{93 "Qӱf}Oj}lo#cfJISۖOty4 qM]O*h|XأhO# RӟړPrʥ2[UUn3Gu5"zgn單B! ڽwU[l1R)$.F9'My*4DD b,\$j (TL+3È`p!SՉX>oPlsJOT<RD" U* pzrÖ?8#2D@/77gb-0DEI ilTttؘ)5JuΤlxu%ŋsMShuǾ|O_o;R}b]YnV3;r%7KZn?|vw?f{VX*+]c::Nqeee)S{J!c FFraq.ZeGE4nh! IR9KuqM&RU?Ds7w9D"13~mK MG,Kmi #/oI>[f_/Z, 5͓ (N_G@ۓn텕RFfXߒ4p2Q 9 YCCr&'cjw*s"bhecF'.-낹j:qH{jÈJulA63ʗgJqbilT qlY}>b&I % 6>>Å0Mcii)+z}v "a҉biƒvD _>i{>J Wa( 4hۍV7hf=SkDhj 1-!Vb9[RƶN# $"NnЉUJ1D:E'uO8ߛ ۬S/9𙇦3q̕o{{O/,++ \>Op,<:m[6Zr_P S؎tI%l[ sDE10ta qD`&O0DDWўʘtۓ[] mrZjMZӻu{|)nb٥td{_</WۆܗVR-74ގ-4_;Ѕ@o\OB2\ @OR_8͇ Jŵ[w䒆Vh.ghٶ2Z_nݞy(GH,L,=I 8#"TJ} &7v+/ڿmtS.kssΜƑ2ihkrF$Ct%Ktiys߫fjqCRyʳݦbd HEj}Λ04Mu59kz^D<1NiM+{ʫ^<1Wnnprm>\=S^PD+r9FDiqk P& lGXlTxҳmGhBp.=]zqmwl729c8)jXnDզl=~ͥḚR)Ch†#`[+ZT%l+kLgm4[VT ;4_]߭lߗԋd*ޞfyuǭ^:rv"8MćX\Z<϶z:}z.LR3@"g mm^BJ% H"E#* 30wy/i޸g<>^r\@/j[V zWK:%De g LdTVrRMTvcO jɗ&VP*%1`a@vpwطvLZNwĭk@ (1cPs榤sۑզ,V/,}\8U 8AOt)\?4@OmsHZM.4loBR1s|ߐͦپ~OE  Y6R ɯnݒcu+fPf >\5]0@ZDLD!:NRpnL\/\Xh1$%d#&M#)ny Z#k/ߵ/GA+ĥVf"C\vm󛇇'&jփkR1|Ho""LǍRΤ X.I 1/IvM#C[/lת "蜻ù 0H0H&]St< Z4WhVp@HQl6#9 Pr53 b)bKH"Ig_.TD\(m5l(:J ]`|Tl*]J^~p\A*:נּ4<(c2&Iܰ1̖"l=9ןXqd8%BIDyu9cr`̯`Ab/BVBP/՚d<%( +)}sNDT'O>̳۶o$l"e.P4 Ct'dD(>AJl )Q\CW5qVw\3'uR&zRz4,%P:\Kq]}V}F_eu~'tg._rvdfS1LhooEk7қ:y"8{/˗ ],..+ri`ЍJ<Z)W*9!2hjGj|7DD y{*|NRK˶ "ZlO){؞DDTP]SEgJ.8Vg{--C" trtiz ycs _XL.1jp#4+loNWw8vi?yefD';3[NksG;W[[aJUm}CQ zRga A˓o}[{ .FQ!B. F { dC=}+H6*n?0uy}q]1X5g߽g`bjMwBcow%}^q3ss@?5h_%Tyf+Bl//ڒi j`7c M[]Y1"-~To4-6/ES'oLY49jH1}=TL053BTF)sragCI & = J5Juypb xJ)@|:+U f|'!) Ϫ89< תw5Y12Bl~B7Tnz7f[)[CUry|kro"ixѾ޾X,fǙ_Qc0QMnUh;qrؔR5]g}q3 h< 덾xۮc ~q&w4}[z omGGU˥vvqScZ>2I \-׌h4u<“J.0=:0Y˅>jS <4uOc,GaHKsDD9hmWl@{%^Q}ۛ;JR OMlּU |d0[~Hֲ& M|ז-F$2W&J`|4#ϗDj8ܨ޶ Jn@*7*vj#y0Ж o9޻/֫WՁbSLI4cр H c 100C9ʖ@%RbjS\K7w}dK$uTwO{ַ^^/dxʶ$tddfRTDJ MQTBH/`,)-:XnMG[ z>PNk{\6d%nZ/, UziʍDꩆ{4g'U }/$%C,bRȁ1+"P!x\qy9)Wsٹ^'%MOG* u7fb;c\68KW+;F͚Ld,M**f<ӧ\8ff^r>3J(9a+`raƂkČqv""7,-/tBTEDD+84J2Md^ e\;>\XڞBȧ6*7,IhZ}goOf|9Kc|N&Kx)A$ ̄QdS@d+IwR2| lۆGqւ9/lE$tGlYIRC./ƂלZ/hU kTc1HyтX\Z/uNѷHL@P̏-2X-L@ɘ974E񂊩sbiTBN!C%v"!x4ꎂDW_xJvވ3qƭ'ݣBQrƍ_zy.7MF $RH *@&cjVt XrKD %AaZ817nZ˽^'cS)fAmJSo08}~qahfs49ޚP%dʡ/*c,SYc0 iؚ8)T,gRBM)g,bH( 4)xP"fUJJFtv(MfZpt# Ѩ"lChM&Eo,W7 c3q =`0XZZ FԛMiw:]ma̎6?' X >vsgBAX4tЬ7b u!ryi EN8&~|n mhkW y{I2;wdj_)Dx>yfR7EJ@ZR&;IoзLSu Cx2FDJR6\YIK$c@̢ZcIsaw^R7}Ec8]%Bf>Yw=I@E|W*C)1o+? !)n'\>c1gJ EDC5a_2S]$)6\=5K ޛERQIox'Z9ٵ#꺪ś1~]STJxV"AeDԏ]mvJvܹ^xʪeZmAPV=iBHN/1aZ鱕\(SuDaت\f Z.B/&H)Ar)]ǍZ*CVI(Q@MjsTo.:s./7i f~NҩMxf')IJ?}~ް3 8Ek@m| v I]ɧ^p=WH:Bi]kPJAEm(DsF ĜC 2,Ul56ݱUʥR͙(Rhz]'8Bc?F1nWSb2`[BQݸq-//hw:Bi0)Tܽia{0R@-2Mjp\t[KMA峧K8ewÕDSGhd!q4y\sM2tPlBAjF(q cvѭ*13T%vp`z0{qrr8pL.a0/嚡cmJ|WTB.Ǝ]Y<(QR &($ #А1$ !yGjR>~1MSƓ٭^}g (4(9bS;'֙:" .\1Hw P 3 ?? P|gTM;/W*PH!xCO q!?YTkp8ygwܝ*Q]H0)%e8^rwCUE#; Y 2cl4[R1$xA@ewZѭ ۵Y9'0KnY$GcOStTt yWBzRDFG.DSU/4U5V([Y Ec&`v8,H) bտwSw;GRʤ6@ ?J!]#G߅/Ovk USQtP`B0T8-vcƫZ.f3OU+WZ3u 4MZr~Ħ)LD(LJG0ĝ0tޤ(w!lln*z֭x1Ur|֭{( pvJrky(A+1 FnUZ (3EKUYt3#jGA>RY2QvY(eC5z~bEXs-y{i^໎#I,R(ZV櫓=Q5UQm˖BQج6R$P=gRʈ (PTu0P$D*֨ ݸr3]#&D߽-s)p.V |\,sԟhI$@]N1| 9.Ӑ-;oȒB~kn|_$$iٖtJr,b$"UQB"4B<"(s %/G]Y x8>Zp]$\֝ƪJX:%Kv%(~EJg0WC$bdeY2׾8=p0h4`}mmWd> 8\YRn/eK}fjVN`lvtCm֏"P.nfp|\/yL H 1 sER+ƍq'~gYvEgϞYtU)1.*Z"3]׫%8sq\ޅߛB.!@ʚ,?XUFmSʎ֙FPw5p„yƟjÐ>F#~ثuS1bJ%^3 ×_~ W_}KnAx҉+bFF"!A&ERSSPIkMIk^k`2-Av*⚽ϸȬ C% 1d?請16N_ ucVֻS`qBntP89셠P/ G^tM,j ,dUW>yJq>ԥۇ$KD{u-qDR4z>]P,So*+\=yD4`R*u]/8N=y;VRVsz^ۆaH,y LE"))Jg;]qw~wݽ}rA<|;/s\>lWMj@ݿ~Q6?]_oqjgwߕgeQ8V$JIdKf ×_~ٲ0._;s>|ϟ;%Dq B%g}zIq0w'^ ٹKߕM( ۻs}U I Ő 9/'Q:h4TҞtR0E@)>Eq$%0N  c?65X*XS~R*.ZZc/;ù`[mKIfx? " kk9~瓙7z@BY(zhaWU+Wܽ{RVx&'4RG3TWޟM-8#\(4$\1T &<ԩ[; 3+k1%;H.M0 Te4WWjgOojd9riI3L1i@ֲ'Mxf[+z*z$ ԤFjR䓗l:yrkmmΟoזAH@ØIB$P@y49hhb.% ~h6 XԼŘSwth^r]Ey`꘦0LurGF&JZ&KI(ϝXEԸ7 b뭊Z6qqȋX֒'{J|TqST%tf{XE :ͭsۭ~j2!ݩA7f\,?ߕͲDS]DI/FqpT jQqPA4 _Z^Ha~cR X 5廀E]FE!a6VN'QT!4'v1'ԏvc7.E z!X+A*J0-✀4\#DtGUXK^ ì:|c2ZCHgb&2wa`\(+8:P<^nB&3gr0 RK~.u]Z#oR8^|޻w}cc6A˓$0J҅sΟ>ycp38!w}: ,/{B.ց)1dnkyl8 b?䎡\/<,ްXyf(뽀 cW? @)8 X4!d>h|@]AN}GN(jj5bq_)$aȤ!J.FԀia8OwbKD~p4*`E1d%s=qH9JܹfRJgW*0hR26KQD{I6`h<;0}wWuKr 4kS.wk :Wj֝;x㳟yK>ƛo>O'SB)0B tC+^۶߅x__ַo~3 C˲(%np+/_?Kg/\P !6֝Y2^KY;G:=Ɠe*b)%)GJ.|)d&K28>)KspFD=)'T2Hv”K}KE 8AU"Jx,Z4 (HaETIJb I)o~n/${;cLyVNV$R?rڝ~ɝL3PCiLh%O'1cʴE9`Zk LVɬf1Nݝd7z0bK6+յJ'Tu8A8WW[gf٩ӧ˥R-H)Y¯=r}̙3'Ozil۾sn Wr?Sh8wٍ͉ۣ 5RTjB UR꺁Rb${;f\21.v!TX}.sc#rWR?Ʒs)CUg"9Ʌ) iŝ[lW)X<4 .T4 O&O@X#Z.w.oMnYĆ^ҕç79L/hO9qUJedN|Rla3!A>܅FG%Bs N, 8pBJ^as] BXT͚}>L i--!7JJTH!Ga) :JA^/Wpق 5jtX2jB`4\,%P Aa,B$Śz q<ƞ[[>gi'e˶yJ̢\4Lz(*HGy2_K鵅 g $SB ]i $ʔwe;Tsz+--4pq=V`o^=?*7-E)뗯 C7{IB.tl6RD}1ygNt_2 76f>7UAE˙W Gh $~U b4b!-zKJaTV|qDym;;;B(Wy0<<lcPJ9٦\oi/?ڋ6~{ғW]N, UH|EA6 Cٗ\srPns_ y J)ݷNx>gK{o2院(yaa"͆s|f̦hSn%(Z4J5wۛFr0s)1ĵ{yEUe"W f_O*RJPTD !dOw-fb\4<0)%;jT;rѴM@ .4r8}th~#-.Q훷%2d\@uj8UUz3{;+͕d+yV_Og@T:fxJN6~ӟFDBh:!/( E)J@h{SϷ ÕmJ߻;}'^}啓ۿϋWnMNY|a6 "95hN͒YRU1j26pP2%n`1346tڬ6Ճ.}=g+%"z}uލl&g30U/]OK0QxTRLsx!ΒXT=3@DTlD:@n3m<r2M]iܛJa}z(2qdð?O/;Iҝ(?6L U-?.I;;Cja5ݱ|-NB>vǗ2dΨK.9/@ 9\@BcPa1w)"=m*7oT\HZ$8RJoܸ麮i}۶/=wfo?UjΝTCO<sL0UZ̒])U]vg{AI8V6Ɣ? E!v b!$+uฎ'CdfZ}pOyrg_3.ڛw6Oљy ѨT3RMkq+Ju*7v{}۶{ݮKSAl6N4*?/V1dnݺ/h4y۷mC}M FSHܻS֌O_K'Oǟ^ ."&dwb/?_];gmy_P*8g+R (E3@J2hh #!eng9\áSeٳI/tu[޳V%۾ùk%w3y1FD?b?ߕ wEGa Vu0 3CUU M4u0WQ@(,xn1fLS4t (]EDDL&nZji5*[s3P,A`&Zp8d@X)$E>d`%H)p_)PB暧Nm) XX&h*TCqjB6mݞL˭j2ouTì^'ͳO}ncgݻ_ ڌk7~SnZ`.T5H8#|W9D  ʘr 2Ï2fs7iν4ˍws^o,;Wǿsp$YLG٥!E{R@5bliD)E&uR)㑔R,:+a\rJ.*B3>؃DXytȟUJI>b( WҪ=Or @wkk餺vz2l*&ia($׾6WV[|Î{o BEyV]ME14R)/.Y0'V a٦spp`4,:=),Lȋe)R Go=HI8hm,[a\y?3nc^>؏s=QMWQGZy ǾNjJK.||W?XnKcgjWt",3{llUT ^8(+usik3Rp9b\﷧ɸ*Hqx.B<'/EABՋd[|(9GvvvfUT5Kww Ţi'{mjX@afS@dFϭ_սy4.rZǫ7 YfLe4T,% .Rws}t3OnXqcG>a%C f$ڏJaߵx]қ352z>['6ǁַ~?^NͿH~N࿈bFc#ǹuQ$_y2\ avV7(,NR*kZ36Ý[=zb}]qΝAB\~\@\8wɩ{AЬVa<4R~`J.Uþ^֓1ܙ\p. c?֪6Hd2YkIQ9 63C G?kӴ&'>=4sݟ =ӪO7-amn]^t EBweS$WTm߃~ wɹKJ+Hٟ7^iU9xػӫzdn)H"Ӟ^i|VknZʆ~{|fdSOn\N\~]$paaͪdZ@K hD0+͢[m܂J[[響zQktwo駞 a )O٦;ڶUMB3rq8 )Q.6aɚ˄$bbPfgJcB@kE#`s{9ϫz__ЮK=jtz?} TnR45E6.|,N"2wS 6`·7oWfIt~15@YxlK<PSeʥl_k]]bO'ȋ~Z!L~)n eEUAQQlf<ߕ,5p}"&Ib u~[9@uhm\\8NZw-Lԥ/o(Rj׏fQwUڹOl>{ FBݬqHZnXDƶ$7onm/}[]c K<Ԯ;;wh6O{~(( :i;kpp⃊ɮ\~]ubXߕĐ-8wʋy5y~sِwfSA- jԙwpa?~\m^OqqnZѣg< w<B%ܟZȤj1dgUjfjgpsvJy}6&Q-mg(ѠhevaoQYYȵgIJ zZ#!ݛ=).2px:L hUEѿk0q*{{Vn?6$sK+WƳx`کz(='dS zI, ƊXC}Ȋr.xt|p~h( j%;Yr1l'4<ש+j5IS J8aK|sxз7oGm4 M?czwA \ (0O\haZ>!:D,OI$[8{BN#( XԪ[Ei*@"߸}(E>*YP0jRѩ%ރbT6g*kwFҹ$썂So`'@ĵrzHVjd>MRpp΄qwf^?`iwcT^Q].].hTw0r8g`2 n[zvj-tJUiTJfuU,Joq{s* fރz,Xq? 5r,qkvuK/xp2XDQTB,;AQ%qvVᾷ}{Y6Ϯ%|胼peoqD'_3 :t¬;jpKm|ud{`K ZꕫCO&B'i"R+-1y\* X^ ,۲$bA> ^7ΦaJ~ 0'O9^^=@9溊np3\_srupa r5I7x#Mӗ>0 o޺=L ǵZm>oFٶK@{}j\)7Y/ۏ)2r1̀3 yA" u`y;YIWQq̉I$qwį>$LS!$!i3i:I\YNdh6"?딣XX )2@$U ,/'DzIA%*C.@)W(A~A-5˚*`cI6N1,^@4@KL柾r0\* :Hv"(ҵ4N90!1`6gٜ!?ƯoR)@(ňyP}#XZбX)_?[[J{wgѣ$IjQ.w]o=G]<6?R _仞cXO]n6[BB%o+R.ǣٍ%vnBn-X]64.w$m]c$I;+|ՃquS_.!dL4'l pLŶe/ZQLy[QK)ZI D Iˎ=Omص,߲)Υ 8r1ŬD6oOAӛ)*)Ĵ.LMBKNIĐBg'NV~?HRӕiM@yfM_պ8% dO^T='#jp? fж4N667~`l6O`vȈכVƛ?m5ۀYe 3gt럾83,.@<]oQJ $ه6SgsՉKx+L&$ 5x^ ZZܕL fIF 0 )E ܜsw|t@eGXHnh7CEkiP (ߩbjv h\+$ 3-)UqLix9oZez q߸p@ KS*ߥ&\JЀ}QpTsegĂw$͟_dsFB8 c L>cF>EV w}V4jȘy:F'⹼b,_nTβ%߃ {}pws0^ӗ%<FQŪRX$!?GI*D-ǹqFs&ID,D" Q= y:ߕMKW_ yB0,N#n\OcaI \WarWvfBXYߕIX^3"j'.cz4L2Xgxrnpi%\z..,w]XGh CSȸV.$I^z֥KTL&u r ȷ=@8$I_RDZOihTU| LDp20@Sę1V][ZO'@^`D0$Z3\8/^έ99|ҏ T~2FѰ4.N48}F!U$,tov`%W\bl.oi$T6 ՝\tǑU"+kZ5GZ}ey98I]ǣA v Ԭ:Y"asFfY[2332c4*gW&sǍܹY}Y)OHv|qbwЏA)VSUZFQg !͹$k9a 5|b|2AC.D}*D\T@wQ;Ȑz!Q![l%y*SCW&J{7ooM҃+nTVo;@̔|UT]E#4^1D BBaW^?˫YJ́('D 4RD<#,IX C; "| 8l^4FTz2].%!1nvCkws)FBߥﭭ;_~xt\f)H!\8?(@aZV6eŸ0 iwgR|F't*0JulCۧ(I\.TD$axo۽^ I_.T=d}9E@1uTQ!1lB3G(FH9[SP?'xYm+n/)L#]3-βu#r8K8+א3ߕ)V\#mj[YߥW<͵َm$}f9 d[+zpwWJ9K?]\e-LH"d2TskqG;[{Wʻs5ٯ A+9$ºd]zt4Z 8R1|R>D\V"{0; {nòJh40lۜ19cRgLd LɃI!QP[,Ξ MG?叽WyƲjroL,\<5 <ټlprV _zc!*wV?ZO5KubZao(9:q eΕMXuil aRbTbΫY Q(swwz0XT J{8El>Ig9!nt:DD@H-Υ83)e,Y,8RNE 3STwsǂ? <9Z8U蘟Y_%:=M[:f#Kgϝ-Wa L| 1hSowk+U"!,ڥ$R2*R-pr97n '!jvI{<)|WݷTf]Bc(2dK` +Ջ+n/o?xxf7{c>]è.u:Νۂ$C6c[ԷXE& Wgy41b= 5&ժWMr;/GyJ[vhV۔ z:6WV;v%叝oی!4{ʉ ?}+\D{n*; $t쮖7S:g;7vGǓh~mǡ`2}+NW?qʇrK<a,##^gI|"d9gW4n9qJRz]?%}035h^ gn>wBP3~u4'{ƚ/Fi߱I 0 "C r۵p-FcٽI ,3 cD7ӨFW㻸oʗ~*p]wu_# Bd_u:*@"`(#]c<Dd[Pp^2ς Dwe jY#"0d:8 KUJ.Zw0~T7|WujbƉɢћ#$ߕ(cw,4sjj~eXopl1-@ Ø16c;TqxwYCgAPi𭭳%lYl:sN}2M-8Nٟ#CX"f/jRMM+Ke;(< ۞L4gwyW^~]1T+>  ]{/KwUh*Ny}[e\rD XI!b󝵺N$Z|j_ixG#&Df$$}ib>>| 1,ʓٌHR @YrNFrs%qq ӄnAl8AX"y_./_K83 p{~xpwHm`^oO֭ru:|vFkkkݻդ~Q$ѵ\ aQ=ZZj.K`qJuŋmyo+NU3D"$Wo!d<$lg_o|wΝȯ$R]{$ϬVwA0ل~n."h+jݷ.22Nbv:{F+Hbl@p-qx0O8MBߕ&)qFci;tj5!N,V֯<}bm6RVuyA۝f|Wf=օg cQMY@].៿b1FdQm̓8T*m$iLmH$P,@DZ__Ϸw›3Bxלr iW"MB8nJY<%x]0 G.]JLV%gavnw^_ٖj{\&UYP;T@0 O3woKch^|zV8"1ĒU"]2mo~˲tw4nmm!|>h4*fɶ!{y#/>[%sNٺrJ I!޻2]ZWwυQliǓ}ʾUyZq=>6Wu2fA$Y_oTk鄱+ /ovX歹?x}(VQ|ҹGQGTyzӅHe/>_ѥr+6'nwJZWVB?.u8V._c_}[?ME"8 C^k/{<Ξ9W_||K!E,ÒU֧>ҿz̲WV_fg)ۜE@3!1ɓ.EẑސHqZ:G’܍z[e˂!0d L&2#۲`wʼnXx*-ԻS|mmvM7Eo,Ue^w{dR=x]بl6[-u Q"wvd;`@/jl~ԙ|',* D}wqixMIٱyq{#kkkٴn[\غp:olgZܲX9̙;ַ.2n)/? c*[2r-RǏ^\w9H­6!|<>)ET.ioƸ纪 V`ڨ58Am9#Ј=.tfq^>P: #kiZp7gk~ʅl!+H2~ce? ѠTjW9y|WuZeGA*dTvm-&FvZJƵ3ok/8YHOZ=*j-pAms' oD FiYbluyyom|.z>s^EN"9X|3W?mewe5 gno<.bBJT d$MjVb!v|_*ō=:Ox= +I$ϓMyx};wweDb@Υ38M-q'$]ǽ;8AҊc9 g(DD!YIw@=oY 1v0[6c.D6yCbę䑑DB>!x|m߻'XYn ^q\7MyZ˵Y ϸq|Yv٬ R)ixQՂSާ]y2͒y$*[zn|WRͷݻ7˓զDWjCDBdFDB1U wew!>ޓ^W!&KΜ~=J4n-b'9@O#r$DTd Owڮ[B@K{<[bp@/,]{vtڽ|߽r>)"̒y($BuO}F=D0' ۽$̢t mRw]hB,8ڒ$CR$2%])e.i.x^N]? %{%18k/$ay.C!r~Ckrw(|Y!?DXJ7|) x9~!|Wwz+[.H }~}$˄q "0N;Ƴ>;}߿~:szkw ̓1yGTn2Fz3ڼUr@<(@zQ/(tAӛW>2N?KlW^y{i џ[(_#- 뾝aԼ~#I7~0vv;ڣ Lc]:Gߕ, TV|>|5͋`yaT`ľc1}k6Oso,V-و셗~=O䕈']d9~K!ͮ)]gHDM{8"\ ~ RcN)E*[YwBK' kya@*& LaR1>%b0gsA~,]UJ900%~/>=>Ǿ_={ғ.ι\]pO%"JQ b\Mv d+rƘ^G,"G;RSfIꀊ_.Qo|VA͹"p^Yz@h?"Ole&IKd8򥯄/RC/z\?yfR\|ѱIYLTg CPy1J$yV=KQ?Ab" (I]z@F2V#JNeH3y(B'\)hLD?r<̇?x]jy]d gtZ֑v Kg8Ϙt(a7:~$K#"TpUYŵ2KkNY@/<(&0u2$VwH[&45Y%Dd'.dų2BN E+;,bH]ϐjwm )$<-|^*9oVV$thE|uJ!VA=|j\YnW?*ߥg{Lx|g eJ KDѤJ/sF7qQ8Gfz#XȬh8ej(ކԢhfBFFwT27:H?( Z|N 3^sCҌTo"iA͐r-)S 8P (GV P*(t̊<*!!<R(4DzJGm(F܋DH: S*?Dc)%%aKeUC+Z;8WJ Oow'\bQܟucq RJ+K",jx &Ռ9E<ҌEy~.j),\K0S, w)]@)NOA@aaLI.Ig<30fBBGQ8IV{'%GY(5C|@1_2* *+^) )YL$MdEڶuzp2'Zf8i՚ĐS#o)Y.V5O4jQh'\H-T4* vWʉ/md,DĒg-],`WvSVda` @UkvҦ.lVL\͊o^o*C)Pm Z %UvB#0$ H|/!X?Ƚ +*Oz$EP*hE۠7$ Bџ2[]-{xv`]œ} t]Heem e31~IA * k!bֲU!=\>u?DRFz-Vg*# 2:ĐZt %%Ȃ "m ( URuC@qC[PrR!ڪo.+ĸjS:\kaF?aߡPʍ* 3]T´Q;ݟE"Uy9veȁN͵R c~daBMPlLBDAa"*{jS烐ZwB.4ty4W s9O8f`@ѧYyҝ%$NZAYT(B²t*"2+7-: s%B6 UbB욏UQ{)=ÂmyNP,9IWҷ/J[ÔtsC"mHjL̈́ghe+Zh-xQeY<BJoO3PBF{EGx3t/,HJΘEځ4|2!c 0F#hJl bb9w45Ղ.Xd6PLrnh*g'$}dHJ!9~\ O$Mq]'y@RJ)έ&߅g5G.Kr1EL~/RJ$irOs^2?o;;ϮnW>> p[stjIDwno]ҷzu_}n?,̨Cf{s\}h}B3^ͿyYϦ;?<^C- EпypbPR߅6ɼ'"g8_7ߥU '`NvF` ĩZe2_"'JAoqnqrl  NYT Z' j.LjXތvܮThwKg.\yt&"&I8ng42]ןz#d6o|vǖԚpWhsw~W aNZ$F{ix a{UƘH3J p(1DS  3(^;?I28g9 q‰1$s>;yʼnUK,v#I(I$KG/|ldIPg"hdXd`!x JA gx7.ܵ8$}2F1;1J6)6+%5 S2.-ȬM9W'\P""#z4u18c,Ysqҥ`צ sNLy)>.h5Ņ6bPJ'AwcـHϬ= Oxp,6Z O/MOc&\Np 8Kb-Иs v1;OU\Zuz/\zOCwI\0xi]IEO>'}-D,i\C0'bZϨ-wG) MNja_ };{zT:E<9Qitcz.'~N0?,\ ʽӼ.{wBZCΟUca >5REevԥPǮ-6UHqf:-{0 ؠS̿jZ!ik]!̆&űH+*j֒CDUm a3zD-qqi DJZD] fX2&f"{:wi/sFhhqɜQ3'.*af,-'nZpWhx/NF»I<0]DWj:)2rA㏢- Yc&%0r߂RkAQ̡- Ii=ZޛIr\㎼שׁ@8((Pĕvvd6_;1he2ΚvfHZI $h4꫎;#*#="2QGU=5 0 ~ac[.Lv7(ܮl!H&M(yQ";A+ $<{3EHͦԀob8Τu[` 0fC٬ % @6%+B̀{&_d6is̆CfLP̢.%|LHHiPkj'X59ܕyo-0d`NO6=Ҥ(zεXYB^f#AɏؕYsNKKEWf쬠:Kˉ@?_%htXJR#i ˲RAnW["{v>Rd2LXSg;Cj6&G&of[΋>zZGå}g珿ㅒj4][}RLQ P(f庲ov@f A?:܄N;(RIɉ3 {o1wJ'R/Z_^ wVk֍{Հn׎M8ZܬO̕qz<*n5珸jC/1g\j?NzaqVw'\o\/ ^neX'o~Fd>Z~^ խiG/菙{SS|.tb%)/_K]Y,r}iz9G٬ˊ, UoH/cfwgfw>%;6ڽo4hlIRT:vZ\"ժARu^w2!/8Sw7?ZHdƝ]~"Od 5!p}j uF#o4)v6M_}~u_nSW^b$ q?8k[OuS@)"դ 'Ikώ:>Z?xJ.[$/{co7 ŭT !JF/?J_4n~a(޿;ZL~O\N!exO؂D:9,  bi0{ͳ3˷KW+aAxDsYn|Lq vn6zu޹UU+9`iyUgZ^O "д2۬@MEe?|mS܅~bx*uϞt}Tynyny{~e B? ?( j>Zҏ.)+HAQzV߻](Dw?xhwN;\Ibt^5SyH .wVU~|Χ=daQcw}̋V WB 4msJeX h M5jYXX0 r[J< >lZ@BBGdEkU pOG!-VeM;0_kiNzL[p/T$}N$Y)eT' C6MMvGip:Z2ʖF[5czؿ/rVRpqzKҞ8q9IgZS zdq2NDݑŪ̱T$MRo*NxF[ehh29$bLdn3YFNNGr]:RMx!`1"]`$qd>cnh=}7ur]*b̦Яpx'?ߵo8z<*Z SX߬:/,ͭ|^OӿDyHsl8]`o2& $~,Ng| ;'ML_Lol[Qc8sgSS?f zkDnІ2*3Srx c @]IY, $΄&W-9[uOHABvԨ_,z~5?@>dw$#RI2GȘ":KFH2Lwjj(32#f@a gb]&i`d[A;<%l>lQL0-̑^CX)aa 6{ s`?tqY͚00^i 4l]6Ce0l1QnPb !AM=`lwA]y507X_|wAd42eev6ouΛY&Ꚋt#ۃ"#dWL<e|WHR6== K?ܨl6<*쌎gˉDYKO,,1]\y?/Ee#oI4]VKeEeziiffb}Ū! O{t滬 ]7ntTk6;cg|F4fˋ~ѱb=6b! z77S8Y|^kc#968!0T-9+j'8a|8P7, ǎMxl},[]v^'Pʝ\6vw~\ߺ~N&7jF2Yd~W_y${t4МBYd!`+yZy ] kǎMST*FFBC28(sȄ,ƬkEz6l.a $Ii:##JQ(T~Xd~~zeeG(*ϳswf&6=="I$Q(8Y8l\C/푌oy}>EvԨ_}(|:365{XdkB&,5l P;`pJHI %0-ba{;=99La˲.B|0⤱3pր!ay&LfH L؃kL,B02 Iܓ5& C(" HonEn^Gbaq,6džJLdy2&0#}Hŀߟ,B˲ҍd[,jssAX h!|W.VlA#2T4M-/{w^o '&:ZQ*#$;;⪪V mb8 msg唰؆?.O$rds*U(jG^]ygzduo6X\j6E@nnnlqq{k+珬Ee魭n < k_LVk..n?̼!Cs8wz|WfKn{'aבaHU_4X "D`"\ciGAicKCEJ]ze# gNGfY!J4UXVhYTUeExKlaX,3gw-}@g!<#;%ӆf0?;|MP; E14Ͱl/8+>.|ava!p.t]feEeYch:,4壅^!@,c#GeUUƃ> 31_mZLN0EeJ-hBŋO>%>`ГJmil,p>K?AJD}t:MS#fS RgO$f08Y9%,,!fO3:b fQMC>& J $4IB.]8F߯_0wj&SVÉDnmmp#,E|>_Y[K$9:/u%F҉Vl⮗&EaCw-(Lk"FO#+2+}]D62I B[ VtǏONܹj:~|" b-Ѱ,sscsw7/[C4M=ıthW$|iMBv]TlVZ2Užl3?w<. |Wk ( %yZ tdcl؁[m:w &̚S)Hmjg2.A0Vz{(=w!ؔ~<\VbN 0v=Kf7Tw&w00oJ=0[ww=HV";jԯOq@v9|DX;vl|uu7LO7L42( c\(TXTdgENF0^㸾d:]|SFb6[.Ґ|WX{ck_3Sߣ+˕C!o*U$鱱Kå'&77Z ^|KQNGv:ٔD"]F%а:1~heY}p& ]@=LOj6&Gљx6TtDՃ۱-/("&LRoO2ԓ}ub楷n-eYA0iEC$ϘkqOO-R~hf `{P-. r`'PYaZ>`c!/:t@.,dDjEg0RFad+zL0ޚD& Tkl,rp0vOphNQèW%fgGIZY4FG##et{+Y]=g}O1ߵ=wno/xv t66Gu~κ\b4y67SѨVVsϳDnl,bāfu" A.k^@&n,!3Z&jub ܑť O;ez (Ǩ[Ha腅ggVWwwwѣcTD6e2[[xwf!EʃMUy/*y맓dh@zy&~$ .z|{asX wO& F gxKΑK_Vܘ#n/a/kF _|"R7D=;`h1u1dZ& "KDdys|݊|dwu[IRA͘=Y#󩖮 3X5fhF݂?C].l"{wfnZ=?~#i߳ v-U0ԉI׿? Udh=%3ya_CO {s:w}jwhEҭLJ3>$U O'ϋyM?&.S莀0Z03ɴ~.W. B]z3Ϟ٬5Z4r].й9w >"m_n4ZK:'\~ni,Vyzf+OeI਎BFz޼^<}s1B'^0v2fn'ȶlZn)_, Q+uEw>l\lYP&? G=>Zѓ->|&%v#}y'3;|R/>yj/^`߸^ p!HV{Pѣz`l[QWOMƜ؆`9еKXX(]Zm* Rp!ndhzbUy~l7_gwn;zKjKNbr 4ZO4߼^].)wyU+'۪K5 _WmuTM;,$ ~X'÷k6jA );?M˭cΏ+/}>J52 9`#,c~]9wݩ7t|WG~ȈxtquϞ[԰s3 m芁WQOh udm(Yhx< ܄-KB{O]z XslFnVN:͐cӧ| k_~*)Ia!ntĐ+I0ϴ#>NQq|୍ڗ?ԕh[a'ȶu!?~CzNLno:s1Ū Aܘ%1/?8b7MyfrGN&QG( ThG%E!)dĤ+\"KO"99t^ew':]>r֩Gd'24;j'Kǁpc+QoӔ1_lIq?sm AOv_t;oJb־Q d2etޖɚK .xАc!4rY0G#2vR25h&cYmlbΡ9}I>xaL;,//u:wygdd\.OMMy< `c4yEQB4MKxxZN&X, h4wnléklyyyll,J@XOf\V~>-vu@ K(ҩ{]X\ܹ\gf(|X,L&~,pRH$~ <˲Ej5A0ƕJ%Z- ,4L&5MbO<ĝ;wΞ=[,^/I!eFHD(qV(VVa8Av*ű,iMQn5gk5z~jMcpUE.MG'lѣ|~hhpeH$)f4Mx`$2d@\ǓdBPP|@EqO&>rH,3UL&3>>bd_w w1@Q(kϲܤ(&,9rn_|T*]pP(3 aenlO$GG:[oKKDBTOCKKXZǎ!I$:wFllNp㝉 ac#Y*NO>t:(bݻJ{9v\oٳg t ֖.=k׮=cc0fjyy9 BVڵk>,Z655EQ[m߭]f^A@gOC/˞Dz]}$Irsܕ+WVU(BP$H$yo4jn޼t:WWWr677s\vcN_uVU4($v3G  Νs~Q^Zj=*Z^3P(z<uWԔ##|"!@0ّ$ 677CЭ[`yyZ Z-HlooͭZ ~1i {\.'c=fL7'OLӊ[~7ߌFz"OO?u:[I'C_I}ufPrgt(2ap8 T*Q٬a;%`+^/++Q 06Ƌ"-T  q3?p8(3q;9/-5[۝lVYUH-.e^ b>xvX:35M].CP:gYm}tzW˲S ) L J,03ݽ:  E\0Z-ZL(LQPҁhЧNkzh4L&Ƿ;JRr\,ժc4jHA;~&JNL B3F8:j9r0# ;9-w$"rT/..~+_Y^^zv{fff}}n={vggl VE;wfffRTPOU0+ 4b811 KnZ-V0QT77 qXUAQPC KC&E\y-Qyu17f@@jϧ5MVj<ϝ;w`ssjEQ^V Fn<:x\U^xacctJK? \Z.0taaݻ c=fy=wnsЊ5ZjE_P [c y]%`/BN^x< 㼰lEQ,Vj{4u _sHӴx\GbMs}zʉbgb^$JM Ѡv;')Ti&,hTn<:.812I%+Vp\@|x\H$ƪ~?EQ~]7l6 Zf;(=+ˁ@ L^x((Dh4TFЫ)@I$$[ʉi֜NZ\14eeZMENGrY'%Il\jzKR8IgoÆ-ND"4-ݼJ]w:g,N*u}h~0W(9}|_s2yMW0K @xI--mz4gWO%YoKt߾p^T dԩST* ]v:ujkk+鱱o߾===}ҥӧO4G x< j5դq&ԩS}ޞtciih4 aЅ Mj'&q꣣PULvNzc=5%8+|{ !b._~K(,..nooߟ4Mᅅ4V꫿[E ҥw''Olmm`0=??Yp-׫ol"؊_?7nrvn\ŋW^}CǖdcwI}^I6R},r= "(;e[~rY˗/1}Gio}7o[nB!/_\.:N,?-bYeFqI=1N8###NgjjJ?bY\z{mH~B%N'GGtZ*r`tl,J'OR5MJݻG +++@@x L: lrItҥ'O.//'۷o_fo߾b1v=22qΝJ2<<|ƍr|].r*2,#?,+ͨ0{3>"$A̸,gldAwo%oK/y晵h4xzNܹsieّӧO_t)}:HLOO|_~~\.OdY… ،_r4|@?:<'nN:]GI(Vbt(j  HQHT*`PN$mIbC\@g }w:dgҧ ].$O_ES .WݖȼH_E&?0:6|Epڵg6˗/{drww7ϟ8qt~nFeY B,V522$)VKF![i6]>cE٤dtIp"[,OrV0lҊT4!E|].٤A)Na0D"`0/vXvWWWܹp8x8p;H$zzNyaaAqnk611q5M8wvv)p}޽x<1^\\TEp8\(Eؐ$Ibiiɘ2W''2Vp![TRceEƈܯo!i֛ S=e/z}XWqOEqttT?h=55G|333U355FWWW(X,VVO>-r0`'ieh%_D$__ipաáv<U?3<9%IpX*=+. Nv0izdd^\fj(`0.~nРZ-IQynIL K^+d273'U*m8a<؇`A[`NñE_刦_1([9sj}V/^Ny^O^>"z(kn; ?駟VE'&&H&]__㒄'^mMO {{I sx ^[k"57'V*Tj"9q‘RoQ1F;:,huu옃Q8N\Rs8(YZj;\]mQ d{{̙3>,ܻw/?,ˮlnnNLL_|8wuj?~< gϞszR?l@zcAollsKK%N' Q D$H<ib(вGi/Ap(f|CG?#Z:_ ku htrrR.X,+;$IO=˗www=o|_?/.///ɥB!xv[J-TIٗ_.(ΝsRF{vV(RIv:ZMn q~?y{$9uNv>!LkmB!)L&/^x#Hf23d˗d2T*˥_!777B ҁ0 CӴ>B_eZF[n=/_^___5á=eQN:@ξ}cQ;F>vІ٘{]tk{{'T*<Ϗ9sΝ;'On󭭭:P(O~_~_ gϞ}w;vs}}}rr͛F@`ht<?w\:=s֖w^( ;;;ƽ'H>"t:;V q\. ;r"Ϝ9s-iZS9ri'NSIN"Ky]i;1vCŀq!looONN?v!ds2f**E!A7rѝF114>=Z, =8R8i vA#Ϗ<@`fPVAJ?9ߵ>,\dXW}H{F3 B?#߻{Sy^$-jsAPTMgF^\.^X@DQeҞMkHVSwiC4 *`PUՅt:=77gkJ;w6778 6H$j[}>_^A?rld}*:08 D087fHD*XYFǎ)wz4Ml@jx=A[پ\fΝ+mn{$Rޞ'~~*<ϧǏSE8Barr";(*7onLOOP>Ezy^n`gEfۙlbYb姙2mH(G?j^YYF^ y~ttΝ;n[̙3lVoDžJrzjuuP(pW(fffBmÛ(jf$)@٬:348m^U hN_IBDv{$hPGRyTbi;kTK_- 3LD"/ׯd2Riff&ꛄV[ddY[[|W^xZMOs z2_fΘJh(4gfm,#[$tNJM .%N \oDHwv+LW!(ʘ ~}U`yjl~$ ǗeBfC{L?QQlQ_}w@JOtA4lAgg[{!(g<~" ]gr^  ai$ VUڵkoƓ'O~fp\.dYܼyF|X ahUTaHS;K%9t 2IKT\NN$ yyni Aw\NBͦЭit:ie*:>>bnFVz(ͦ7[ͅ/Qahm܆n,{6 BbM'bb#x@$\a\+e{ ػmK9Q#FEvD gh?\.}UU(J?88XYYA>AHRRivv빱͛7A@ZJ>ub,˚Ml8u5j5=#0 AuŋEH)ˆ NGBQC1tqr"\(C:>}g?;\XpI׮qV\)IR:::V.+͢wNNNX[[+ZA Hf\rxx0LV3337o޴X,.--ݺu룏>^n޽0 rt #A8 (Jdy] BhtqqO?EoujJ-۷nRtzuu`mmΝ;GGGϟ?o4㼂lllȲvvvDQf~?|>j^ꫯ.ǃŭIs&fC"xg,C>(?y`)U!`FL޽hhlPp8E<G#:rq0;;{|| =(FL&CY"(($IKKKFCEd2Fr=|*Zhii&@gWov 4 e٠(xv*۹ܕ7p<;,] Qb N'ŔeP(jFp8ѭ8$z=tg=gd*a0L&ApZd2'''@vD2H\^#VeYAPP.8P0Ѓ6Ry61 w Eﺤ"ʣ(ݝ}ġWedA  t@GG={-àx`cN ڤzq@@z:GN0iH!l E & M%e`8WxLE1s9\uwfЫh `>.ylJxuˈ\΀EYQ$NݦN#4A0x~wbuQ$D7Z-Z01ۭ)%&I)niF A2!;1O ʷǣIPU}n {y3|Qhژiިp= y!rjz"@SUv7'g0:V0c^2$l݄c~Iً*)`<04`0b< Cߚć^`ydY`"Ϟ=-J9??svZVr@?NFnMWy x\q:+?iχnmm7O:z tn ={655U.嵵5]_xH$lXT*X?A\yP(Htzz( ˲X0~lqJhwޘ+\n0fR.1dw^%lLh{#+`pOhRA 8^ ^?4hWvсť%˅9*j& ~ LӔe9핕d2v[c4t:'#XV+Y5tR jg˥Ӵɲ׫:+gݺۭzXL:>vȍr$rɨ*\Z)42\.MhjJ,OEQRTJ$Nb1 <|rݵZ 9f$voyyrE=uV5;; }>MөT l<ʲ^r99;;+B$AD3 _^o qQ~<dRA]|0}>Bp$I14Y:: 3@<!oC0هgg Ta|WW=Pi/IA\foT |=Z^v ~ۻ(Q|UvO r}꺎uݺo{yOH5сBaw 1!BTZFdt$i&Aju=~м2ǔK]7 ì՞%oud)`}tX6d5U#8(gH9&_[@vቴJ϶EQ|sssz z ޽{7ۿqnzt4/8褺@T*q/\as9#n0^8=BAv W˩x}떻PIFt%ūW9~v @|r}*xQٌBannP(,//?}G?Q4}YPXNӅB?1Y7G~'оǧ~[[[,|[*x'eٵ[nq>bxFz>~ mkƲ,ph\ӿ129Lz`aR>S"Ou:P/,[[[nݲz0і5mڅ &8@PU`+?h1c^ >H۝I2OEr??n7 H9AE^qaD˗T*JyO㸹9QܹH$(_}ix4mqq4m??Qh&øH*- OuIוNVy., VDU?PA-hFʲu BH*4\83Ww!M^/GQ,Ke'4TUSQ>_~FMN0fW^Rx 4M* ^AB>4MN$jKNQt0B`&z!jt:}rr 0+R{$XX*9hڌ]$i:<;c ݦD\YQ^J k (܏et(rN4Y֨V)^zK9<, ?h?ZE:4VŎ|M"+U*a&(`vvֺ`7^kÀ{i2 N%IB,"A(9iEi2X]`PlBfcahF|2l8a Rk"f @(02k/V>OevX(*99F\}/ $I.,,looJT*{\\\T*d&-R0 @X8NԛH( czim*Ѩ(DK9 :,kJ0.ȏ!fBxvv>} BzAe}j0 Bh@J%43ij5-"0nZ"ߧb@ Yu4x2zӧ9NI2u>CVB0==dwl-ID4Xϛ}^DT[Ra ggiNruKT* ϓ&Iaê<"v^wzz:6`0H$B#.kff)DMezL&p8,2 Aiq\ZEW---΢jy21q">ᑉՀY%) #9u\Y$I$Ir].$?U$ Iv-{R"H8F,?<#󯿍Ͳ.o.[zq.tZm7vW( i_1L$@QF,&` ւ́4̇ch%ZWH&\]H\n[I(QT,kW6'cٜg  & 8m-I#-L2Xƛaà3OMC?F[o{]{ T|w4!Σc+3.Lbp  qe8= u(NJ ><m7GOJcA v9m JdQ-C0 0@յZՀJjkyE4PU]Uu0EuC5T4on&Vӄʲj$4n t@+4u__ʆQ h<a꺡芢j(atEѰMU=OږEMӱڻ29أ9:8p> q0: - X1ž8d0*v禒Q!>Y6ei0Szx:0 4UUMH}v C&ʕ+ӊRǏRډD++N(j*)kX`f&vxxZw4M<÷77ׯg^8 I"=xz_l[Pmaf&͞ pk(\2]w*}u z$I1 vjA(_b?}w߿L>|ӟ!͹\ZxAe5DQ$jxTj 2SHxͥnW>Vxדߗ8yzXj7ṋݒR<:9)ݜ$SqhpЭV%Uơ|_xE&ys!=8n7˒${<\սre{M^׍Hok7 ` y z<4AvD"UZKK3''n֭ki@}n_:0T'd2Fo'2 bZ{AD05Mw:~_-b-gSSF_ZEUVwMg$EQ播Vu5#J)F.TjA@7bjk( RBsɡW<_ Cfř4@ljňxx28uqTEUєUa`8u`ˆŗaM(Xc 6@-#mYV!:ꃛLA$e\UU I7]HeRʲ0;?TA,+ v!YQTH PaA)*Шaf7>:Eg?kdq!>#.0MS˹;"]Ri(ϟ)Z?~߂3b*8`i2[8|ytbw`3mMy%#'QmB3DFhAӁ~Dik0̅)ϿtOv[hh4nw??X^N+lV/_EqcEU-bdhFH[-ak( C+WfN tʲi:MZ.&@4}YVi4 x4A6[B39wvNVV2T`iF__/3 NǶzkYUU(\(ԐC^V'?;{oe۶%Dd+hӔʕ0cTvvrssB,Jk h6y@$}`4IDa0x  Jkj*|9 H"D(w3~{f&JELEߗsVkn0:IT*N‡% $Iv:d`L"| @&8|V }\6[(o^XU*D"47>t:iMhz]h r%vF("F"BUf<ٝ-/!4M3c39ش[[A m qҘ ɪ:cs$@|0%<\cB]ȱQ7W)&=b@%].""viFH`Vo 7ǹ~"I ptz|g`Ė 3]p]VՖA5GY5NwAK0Z 9.kA<?$4HAL##֒$nİ5^8Ps}v |\'Ov}>w-i*,h;KU z+֋H][ۏF''@{tT>8(RnW<:* gdN=Jj'{=)-u:IBvϏf..dY{ddEbƲzѦ,kPy2FOq}/4u=R#\ݪTPDzssɥGݾi/pǃn!*Evs߻wdH4uB2ƛOL'/[c.]D|H Dh shc,13OCK搩mq4 50 дژ+A"9xZ}zTsSpBxlp0+Fo6`гlnftfAl72n7!IѨrfwo޼9)2AKKӨ) ǃsw:D(rX֎ǃ pt:*F(;.Q+R;,+ЏC5sy+یㆬA|d2}#ɐ&0Pưg?YfJ:ԅqyrK(c 2KZ%IPwI#\@yEIt7^+HJ3C~2OOϦRH'a9b;_OOkTݹ߅߅E1B endstream endobj 238 0 obj << /Type /Page /Parent 3 0 R /Contents 239 0 R >> endobj 239 0 obj << /Length 21307 >> stream 0.271 0.267 0.267 rg q 15.000 106.286 577.500 670.714 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(19;324\(5934\):1557-61. Epub 2009 May 11. PubMed PMID: 19433588.)] TJ ET BT 26.250 748.071 Td /F1 9.8 Tf [(2.)] TJ ET BT 38.132 748.071 Td /F1 9.8 Tf [(Rambaut A, Holmes EC. The early molecular epidemiology of the swine-origin A/H1N1 human influenza pandemic. PLoS )] TJ ET BT 26.250 736.167 Td /F1 9.8 Tf [(Currents: Influenza. 2009 August 18:RRN1003.)] TJ ET BT 26.250 716.762 Td /F1 9.8 Tf [(3.)] TJ ET BT 38.132 716.762 Td /F1 9.8 Tf [(World Health Organization \(2009\) Pandemic \(H1N1\) 2009 - update 65. Cited 2009 Sep 16. )] TJ ET BT 26.250 704.857 Td /F1 9.8 Tf [(http://www.who.int/csr/don/2009_09_11/en/index.html)] TJ ET BT 26.250 685.452 Td /F1 9.8 Tf [(4.)] TJ ET BT 38.132 685.452 Td /F1 9.8 Tf [(Hurt AC, Holien JK, Parker M, Kelso A, Barr IG. Zanamivir-Resistant Influenza Viruses with a Novel Neuraminidase Mutation. )] TJ ET BT 26.250 673.548 Td /F1 9.8 Tf [(J Virol. 2009 Jul 29. [Epub ahead of print] PubMed PMID: 19641000.)] TJ ET BT 26.250 654.143 Td /F1 9.8 Tf [(5.)] TJ ET BT 38.132 654.143 Td /F1 9.8 Tf [(Maurer-Stroh S, Ma J, Lee RT, Sirota FL, Eisenhaber F. Mapping the sequence mutations of the 2009 H1N1 influenza A )] TJ ET BT 26.250 642.238 Td /F1 9.8 Tf [(virus neuraminidase relative to drug and antibody binding sites. Biol Direct. 2009 May 20;4:18; discussion 18. PubMed PMID: )] TJ ET BT 26.250 630.333 Td /F1 9.8 Tf [(19457254; PubMed Central PMCID: PMC2691737.)] TJ ET BT 26.250 610.929 Td /F1 9.8 Tf [(6.)] TJ ET BT 38.132 610.929 Td /F1 9.8 Tf [(Lee MS, Chen MC, Liao YC, Hsiung CA. Identifying potential immunodominant positions and predicting antigenic variants of )] TJ ET BT 26.250 599.024 Td /F1 9.8 Tf [(influenza A/H3N2 viruses. Vaccine. 2007 Nov 23;25\(48\):8133-9. Epub 2007 Oct 5. PubMed PMID: 17950961.)] TJ ET BT 26.250 579.619 Td /F1 9.8 Tf [(7.)] TJ ET BT 38.132 579.619 Td /F1 9.8 Tf [(Parks DH, MacDonald NM, Beiko RG. Tracking the evolution and geographic spread of Influenza A. PLoS Currents: )] TJ ET BT 26.250 567.714 Td /F1 9.8 Tf [(Influenza. 2009 Aug 27:RRN1014)] TJ ET BT 26.250 548.310 Td /F1 9.8 Tf [(8.)] TJ ET BT 38.132 548.310 Td /F1 9.8 Tf [(Parks DH, Porter M, Churcher S, Wang S, Blouin C, Whalley J, Brooks S, Beiko RG. GenGIS: A geospatial information )] TJ ET BT 26.250 536.405 Td /F1 9.8 Tf [(system for genomic data. Genome Res. 2009 Sep 1. [Epub ahead of print] PubMed PMID: 19635847.)] TJ ET BT 26.250 517.000 Td /F1 9.8 Tf [(9.)] TJ ET BT 38.132 517.000 Td /F1 9.8 Tf [(Cock PJ, Antao T, Chang JT, Chapman BA, Cox CJ, Dalke A, Friedberg I, Hamelryck T, Kauff F, Wilczynski B, de Hoon MJ. )] TJ ET BT 26.250 505.095 Td /F1 9.8 Tf [(Biopython: freely available Python tools for computational molecular biology and bioinformatics. Bioinformatics. 2009 Jun )] TJ ET BT 26.250 493.191 Td /F1 9.8 Tf [(1;25\(11\):1422-3. Epub 2009 Mar 20. PubMed PMID: 19304878; PubMed Central PMCID: PMC2682512.)] TJ ET BT 26.250 473.786 Td /F1 9.8 Tf [(10.)] TJ ET BT 43.553 473.786 Td /F1 9.8 Tf [(Edgar RC. MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res. 2004 Mar )] TJ ET BT 26.250 461.881 Td /F1 9.8 Tf [(19;32\(5\):1792-7. Print 2004. PubMed PMID: 15034147; PubMed Central PMCID: PMC390337.)] TJ ET BT 26.250 442.476 Td /F1 9.8 Tf [(11.)] TJ ET BT 43.553 442.476 Td /F1 9.8 Tf [(Han J, Kamber M. Data mining: concepts and techniques. \(Second edition, 2006\). San Francisco: Morgan Kauffman.)] TJ ET BT 26.250 423.072 Td /F1 9.8 Tf [(12.)] TJ ET BT 43.553 423.072 Td /F1 9.8 Tf [(Lombardot T, Kottmann R, Pfeffer H, Richter M, Teeling H, Quast C, Glckner FO. Megx.net--database resources for )] TJ ET BT 26.250 411.167 Td /F1 9.8 Tf [(marine ecological genomics. Nucleic Acids Res. 2006 Jan 1;34\(Database issue\):D390-3. PubMed PMID: 16381894; PubMed )] TJ ET BT 26.250 399.262 Td /F1 9.8 Tf [(Central PMCID: PMC1347433.)] TJ ET BT 26.250 379.857 Td /F1 9.8 Tf [(13.)] TJ ET BT 43.553 379.857 Td /F1 9.8 Tf [(Sheu TG, Deyde VM, Okomo-Adhiambo M, Garten RJ, Xu X, Bright RA, Butler EN, Wallis TR, Klimov AI, Gubareva LV. )] TJ ET BT 26.250 367.953 Td /F1 9.8 Tf [(Surveillance for neuraminidase inhibitor resistance among human influenza A and B viruses circulating worldwide from 2004 to )] TJ ET BT 26.250 356.048 Td /F1 9.8 Tf [(2008. Antimicrob Agents Chemother. 2008 Sep;52\(9\):3284-92. Epub 2008 Jul 14. PubMed PMID: 18625765; PubMed Central )] TJ ET BT 26.250 344.143 Td /F1 9.8 Tf [(PMCID: PMC2533500.)] TJ ET BT 26.250 324.738 Td /F1 9.8 Tf [(14.)] TJ ET BT 43.553 324.738 Td /F1 9.8 Tf [(Garten RJ, Davis CT, Russell CA, Shu B, Lindstrom S, Balish A, Sessions WM, Xu X, Skepner E, Deyde V, Okomo-)] TJ ET BT 26.250 312.834 Td /F1 9.8 Tf [(Adhiambo M, Gubareva L, Barnes J, Smith CB, Emery SL, Hillman MJ, Rivailler P, Smagala J, de Graaf M, Burke DF, Fouchier )] TJ ET BT 26.250 300.929 Td /F1 9.8 Tf [(RA, Pappas C, Alpuche-Aranda CM, Lpez-Gatell H, Olivera H, Lpez I, Myers CA, Faix D, Blair PJ, Yu C, Keene KM, Dotson )] TJ ET BT 26.250 289.024 Td /F1 9.8 Tf [(PD Jr, Boxrud D, Sambol AR, Abid SH, St George K, Bannerman T, Moore AL, Stringer DJ, Blevins P, Demmler-Harrison GJ, )] TJ ET BT 26.250 277.119 Td /F1 9.8 Tf [(Ginsberg M, Kriner P, Waterman S, Smole S, Guevara HF, Belongia EA, Clark PA, Beatrice ST, Donis R, Katz J, Finelli L, )] TJ ET BT 26.250 265.215 Td /F1 9.8 Tf [(Bridges CB, Shaw M, Jernigan DB, Uyeki TM, Smith DJ, Klimov AI, Cox NJ. Antigenic and genetic characteristics of swine-)] TJ ET BT 26.250 253.310 Td /F1 9.8 Tf [(origin 2009 A\(H1N1\) influenza viruses circulating in humans. Science. 2009 Jul 10;325\(5937\):197-201. Epub 2009 May 22. )] TJ ET BT 26.250 241.405 Td /F1 9.8 Tf [(PubMed PMID: 19465683.)] TJ ET BT 26.250 222.000 Td /F1 9.8 Tf [(15.)] TJ ET BT 43.553 222.000 Td /F1 9.8 Tf [(Xu X, Zhu X, Dwek RA, Stevens J, Wilson IA. Structural characterization of the 1918 influenza virus H1N1 neuraminidase. J )] TJ ET BT 26.250 210.096 Td /F1 9.8 Tf [(Virol. 2008 Nov;82\(21\):10493-501. Epub 2008 Aug 20. PubMed PMID: 18715929; PubMed Central PMCID: PMC2573172.)] TJ ET BT 26.250 190.691 Td /F1 9.8 Tf [(16.)] TJ ET BT 43.553 190.691 Td /F1 9.8 Tf [(Stevens J, Corper AL, Basler CF, Taubenberger JK, Palese P, Wilson IA. Structure of the uncleaved human H1 )] TJ ET BT 26.250 178.786 Td /F1 9.8 Tf [(hemagglutinin from the extinct 1918 influenza virus. Science. 2004 Mar 19;303\(5665\):1866-70. Epub 2004 Feb 5. PubMed )] TJ ET BT 26.250 166.881 Td /F1 9.8 Tf [(PMID: 14764887.)] TJ ET BT 26.250 147.477 Td /F1 9.8 Tf [(17.)] TJ ET BT 43.553 147.477 Td /F1 9.8 Tf [(Shih AC, Hsiao TC, Ho MS, Li WH. Simultaneous amino acid substitutions at antigenic sites drive influenza A hemagglutinin )] TJ ET BT 26.250 135.572 Td /F1 9.8 Tf [(evolution. Proc Natl Acad Sci U S A. 2007 Apr 10;104\(15\):6283-8. Epub 2007 Mar 29. PubMed PMID: 17395716; PubMed )] TJ ET BT 26.250 123.667 Td /F1 9.8 Tf [(Central PMCID: PMC1851070.)] TJ ET Q q 15.000 106.286 577.500 670.714 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(19;324\(5934\):1557-61. Epub 2009 May 11. PubMed PMID: 19433588.)] TJ ET BT 26.250 748.071 Td /F1 9.8 Tf [(2.)] TJ ET BT 38.132 748.071 Td /F1 9.8 Tf [(Rambaut A, Holmes EC. The early molecular epidemiology of the swine-origin A/H1N1 human influenza pandemic. PLoS )] TJ ET BT 26.250 736.167 Td /F1 9.8 Tf [(Currents: Influenza. 2009 August 18:RRN1003.)] TJ ET BT 26.250 716.762 Td /F1 9.8 Tf [(3.)] TJ ET BT 38.132 716.762 Td /F1 9.8 Tf [(World Health Organization \(2009\) Pandemic \(H1N1\) 2009 - update 65. Cited 2009 Sep 16. )] TJ ET BT 26.250 704.857 Td /F1 9.8 Tf [(http://www.who.int/csr/don/2009_09_11/en/index.html)] TJ ET BT 26.250 685.452 Td /F1 9.8 Tf [(4.)] TJ ET BT 38.132 685.452 Td /F1 9.8 Tf [(Hurt AC, Holien JK, Parker M, Kelso A, Barr IG. Zanamivir-Resistant Influenza Viruses with a Novel Neuraminidase Mutation. )] TJ ET BT 26.250 673.548 Td /F1 9.8 Tf [(J Virol. 2009 Jul 29. [Epub ahead of print] PubMed PMID: 19641000.)] TJ ET BT 26.250 654.143 Td /F1 9.8 Tf [(5.)] TJ ET BT 38.132 654.143 Td /F1 9.8 Tf [(Maurer-Stroh S, Ma J, Lee RT, Sirota FL, Eisenhaber F. Mapping the sequence mutations of the 2009 H1N1 influenza A )] TJ ET BT 26.250 642.238 Td /F1 9.8 Tf [(virus neuraminidase relative to drug and antibody binding sites. Biol Direct. 2009 May 20;4:18; discussion 18. PubMed PMID: )] TJ ET BT 26.250 630.333 Td /F1 9.8 Tf [(19457254; PubMed Central PMCID: PMC2691737.)] TJ ET BT 26.250 610.929 Td /F1 9.8 Tf [(6.)] TJ ET BT 38.132 610.929 Td /F1 9.8 Tf [(Lee MS, Chen MC, Liao YC, Hsiung CA. Identifying potential immunodominant positions and predicting antigenic variants of )] TJ ET BT 26.250 599.024 Td /F1 9.8 Tf [(influenza A/H3N2 viruses. Vaccine. 2007 Nov 23;25\(48\):8133-9. Epub 2007 Oct 5. PubMed PMID: 17950961.)] TJ ET BT 26.250 579.619 Td /F1 9.8 Tf [(7.)] TJ ET BT 38.132 579.619 Td /F1 9.8 Tf [(Parks DH, MacDonald NM, Beiko RG. Tracking the evolution and geographic spread of Influenza A. PLoS Currents: )] TJ ET BT 26.250 567.714 Td /F1 9.8 Tf [(Influenza. 2009 Aug 27:RRN1014)] TJ ET BT 26.250 548.310 Td /F1 9.8 Tf [(8.)] TJ ET BT 38.132 548.310 Td /F1 9.8 Tf [(Parks DH, Porter M, Churcher S, Wang S, Blouin C, Whalley J, Brooks S, Beiko RG. GenGIS: A geospatial information )] TJ ET BT 26.250 536.405 Td /F1 9.8 Tf [(system for genomic data. Genome Res. 2009 Sep 1. [Epub ahead of print] PubMed PMID: 19635847.)] TJ ET BT 26.250 517.000 Td /F1 9.8 Tf [(9.)] TJ ET BT 38.132 517.000 Td /F1 9.8 Tf [(Cock PJ, Antao T, Chang JT, Chapman BA, Cox CJ, Dalke A, Friedberg I, Hamelryck T, Kauff F, Wilczynski B, de Hoon MJ. )] TJ ET BT 26.250 505.095 Td /F1 9.8 Tf [(Biopython: freely available Python tools for computational molecular biology and bioinformatics. Bioinformatics. 2009 Jun )] TJ ET BT 26.250 493.191 Td /F1 9.8 Tf [(1;25\(11\):1422-3. Epub 2009 Mar 20. PubMed PMID: 19304878; PubMed Central PMCID: PMC2682512.)] TJ ET BT 26.250 473.786 Td /F1 9.8 Tf [(10.)] TJ ET BT 43.553 473.786 Td /F1 9.8 Tf [(Edgar RC. MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res. 2004 Mar )] TJ ET BT 26.250 461.881 Td /F1 9.8 Tf [(19;32\(5\):1792-7. Print 2004. PubMed PMID: 15034147; PubMed Central PMCID: PMC390337.)] TJ ET BT 26.250 442.476 Td /F1 9.8 Tf [(11.)] TJ ET BT 43.553 442.476 Td /F1 9.8 Tf [(Han J, Kamber M. Data mining: concepts and techniques. \(Second edition, 2006\). San Francisco: Morgan Kauffman.)] TJ ET BT 26.250 423.072 Td /F1 9.8 Tf [(12.)] TJ ET BT 43.553 423.072 Td /F1 9.8 Tf [(Lombardot T, Kottmann R, Pfeffer H, Richter M, Teeling H, Quast C, Glckner FO. Megx.net--database resources for )] TJ ET BT 26.250 411.167 Td /F1 9.8 Tf [(marine ecological genomics. Nucleic Acids Res. 2006 Jan 1;34\(Database issue\):D390-3. PubMed PMID: 16381894; PubMed )] TJ ET BT 26.250 399.262 Td /F1 9.8 Tf [(Central PMCID: PMC1347433.)] TJ ET BT 26.250 379.857 Td /F1 9.8 Tf [(13.)] TJ ET BT 43.553 379.857 Td /F1 9.8 Tf [(Sheu TG, Deyde VM, Okomo-Adhiambo M, Garten RJ, Xu X, Bright RA, Butler EN, Wallis TR, Klimov AI, Gubareva LV. )] TJ ET BT 26.250 367.953 Td /F1 9.8 Tf [(Surveillance for neuraminidase inhibitor resistance among human influenza A and B viruses circulating worldwide from 2004 to )] TJ ET BT 26.250 356.048 Td /F1 9.8 Tf [(2008. Antimicrob Agents Chemother. 2008 Sep;52\(9\):3284-92. Epub 2008 Jul 14. PubMed PMID: 18625765; PubMed Central )] TJ ET BT 26.250 344.143 Td /F1 9.8 Tf [(PMCID: PMC2533500.)] TJ ET BT 26.250 324.738 Td /F1 9.8 Tf [(14.)] TJ ET BT 43.553 324.738 Td /F1 9.8 Tf [(Garten RJ, Davis CT, Russell CA, Shu B, Lindstrom S, Balish A, Sessions WM, Xu X, Skepner E, Deyde V, Okomo-)] TJ ET BT 26.250 312.834 Td /F1 9.8 Tf [(Adhiambo M, Gubareva L, Barnes J, Smith CB, Emery SL, Hillman MJ, Rivailler P, Smagala J, de Graaf M, Burke DF, Fouchier )] TJ ET BT 26.250 300.929 Td /F1 9.8 Tf [(RA, Pappas C, Alpuche-Aranda CM, Lpez-Gatell H, Olivera H, Lpez I, Myers CA, Faix D, Blair PJ, Yu C, Keene KM, Dotson )] TJ ET BT 26.250 289.024 Td /F1 9.8 Tf [(PD Jr, Boxrud D, Sambol AR, Abid SH, St George K, Bannerman T, Moore AL, Stringer DJ, Blevins P, Demmler-Harrison GJ, )] TJ ET BT 26.250 277.119 Td /F1 9.8 Tf [(Ginsberg M, Kriner P, Waterman S, Smole S, Guevara HF, Belongia EA, Clark PA, Beatrice ST, Donis R, Katz J, Finelli L, )] TJ ET BT 26.250 265.215 Td /F1 9.8 Tf [(Bridges CB, Shaw M, Jernigan DB, Uyeki TM, Smith DJ, Klimov AI, Cox NJ. Antigenic and genetic characteristics of swine-)] TJ ET BT 26.250 253.310 Td /F1 9.8 Tf [(origin 2009 A\(H1N1\) influenza viruses circulating in humans. Science. 2009 Jul 10;325\(5937\):197-201. Epub 2009 May 22. )] TJ ET BT 26.250 241.405 Td /F1 9.8 Tf [(PubMed PMID: 19465683.)] TJ ET BT 26.250 222.000 Td /F1 9.8 Tf [(15.)] TJ ET BT 43.553 222.000 Td /F1 9.8 Tf [(Xu X, Zhu X, Dwek RA, Stevens J, Wilson IA. Structural characterization of the 1918 influenza virus H1N1 neuraminidase. J )] TJ ET BT 26.250 210.096 Td /F1 9.8 Tf [(Virol. 2008 Nov;82\(21\):10493-501. Epub 2008 Aug 20. PubMed PMID: 18715929; PubMed Central PMCID: PMC2573172.)] TJ ET BT 26.250 190.691 Td /F1 9.8 Tf [(16.)] TJ ET BT 43.553 190.691 Td /F1 9.8 Tf [(Stevens J, Corper AL, Basler CF, Taubenberger JK, Palese P, Wilson IA. Structure of the uncleaved human H1 )] TJ ET BT 26.250 178.786 Td /F1 9.8 Tf [(hemagglutinin from the extinct 1918 influenza virus. Science. 2004 Mar 19;303\(5665\):1866-70. Epub 2004 Feb 5. PubMed )] TJ ET BT 26.250 166.881 Td /F1 9.8 Tf [(PMID: 14764887.)] TJ ET BT 26.250 147.477 Td /F1 9.8 Tf [(17.)] TJ ET BT 43.553 147.477 Td /F1 9.8 Tf [(Shih AC, Hsiao TC, Ho MS, Li WH. Simultaneous amino acid substitutions at antigenic sites drive influenza A hemagglutinin )] TJ ET BT 26.250 135.572 Td /F1 9.8 Tf [(evolution. Proc Natl Acad Sci U S A. 2007 Apr 10;104\(15\):6283-8. Epub 2007 Mar 29. PubMed PMID: 17395716; PubMed )] TJ ET BT 26.250 123.667 Td /F1 9.8 Tf [(Central PMCID: PMC1851070.)] TJ ET Q q 15.000 106.286 577.500 670.714 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(19;324\(5934\):1557-61. Epub 2009 May 11. PubMed PMID: 19433588.)] TJ ET BT 26.250 748.071 Td /F1 9.8 Tf [(2.)] TJ ET BT 38.132 748.071 Td /F1 9.8 Tf [(Rambaut A, Holmes EC. The early molecular epidemiology of the swine-origin A/H1N1 human influenza pandemic. PLoS )] TJ ET BT 26.250 736.167 Td /F1 9.8 Tf [(Currents: Influenza. 2009 August 18:RRN1003.)] TJ ET BT 26.250 716.762 Td /F1 9.8 Tf [(3.)] TJ ET BT 38.132 716.762 Td /F1 9.8 Tf [(World Health Organization \(2009\) Pandemic \(H1N1\) 2009 - update 65. Cited 2009 Sep 16. )] TJ ET BT 26.250 704.857 Td /F1 9.8 Tf [(http://www.who.int/csr/don/2009_09_11/en/index.html)] TJ ET BT 26.250 685.452 Td /F1 9.8 Tf [(4.)] TJ ET BT 38.132 685.452 Td /F1 9.8 Tf [(Hurt AC, Holien JK, Parker M, Kelso A, Barr IG. Zanamivir-Resistant Influenza Viruses with a Novel Neuraminidase Mutation. )] TJ ET BT 26.250 673.548 Td /F1 9.8 Tf [(J Virol. 2009 Jul 29. [Epub ahead of print] PubMed PMID: 19641000.)] TJ ET BT 26.250 654.143 Td /F1 9.8 Tf [(5.)] TJ ET BT 38.132 654.143 Td /F1 9.8 Tf [(Maurer-Stroh S, Ma J, Lee RT, Sirota FL, Eisenhaber F. Mapping the sequence mutations of the 2009 H1N1 influenza A )] TJ ET BT 26.250 642.238 Td /F1 9.8 Tf [(virus neuraminidase relative to drug and antibody binding sites. Biol Direct. 2009 May 20;4:18; discussion 18. PubMed PMID: )] TJ ET BT 26.250 630.333 Td /F1 9.8 Tf [(19457254; PubMed Central PMCID: PMC2691737.)] TJ ET BT 26.250 610.929 Td /F1 9.8 Tf [(6.)] TJ ET BT 38.132 610.929 Td /F1 9.8 Tf [(Lee MS, Chen MC, Liao YC, Hsiung CA. Identifying potential immunodominant positions and predicting antigenic variants of )] TJ ET BT 26.250 599.024 Td /F1 9.8 Tf [(influenza A/H3N2 viruses. Vaccine. 2007 Nov 23;25\(48\):8133-9. Epub 2007 Oct 5. PubMed PMID: 17950961.)] TJ ET BT 26.250 579.619 Td /F1 9.8 Tf [(7.)] TJ ET BT 38.132 579.619 Td /F1 9.8 Tf [(Parks DH, MacDonald NM, Beiko RG. Tracking the evolution and geographic spread of Influenza A. PLoS Currents: )] TJ ET BT 26.250 567.714 Td /F1 9.8 Tf [(Influenza. 2009 Aug 27:RRN1014)] TJ ET BT 26.250 548.310 Td /F1 9.8 Tf [(8.)] TJ ET BT 38.132 548.310 Td /F1 9.8 Tf [(Parks DH, Porter M, Churcher S, Wang S, Blouin C, Whalley J, Brooks S, Beiko RG. GenGIS: A geospatial information )] TJ ET BT 26.250 536.405 Td /F1 9.8 Tf [(system for genomic data. Genome Res. 2009 Sep 1. [Epub ahead of print] PubMed PMID: 19635847.)] TJ ET BT 26.250 517.000 Td /F1 9.8 Tf [(9.)] TJ ET BT 38.132 517.000 Td /F1 9.8 Tf [(Cock PJ, Antao T, Chang JT, Chapman BA, Cox CJ, Dalke A, Friedberg I, Hamelryck T, Kauff F, Wilczynski B, de Hoon MJ. )] TJ ET BT 26.250 505.095 Td /F1 9.8 Tf [(Biopython: freely available Python tools for computational molecular biology and bioinformatics. Bioinformatics. 2009 Jun )] TJ ET BT 26.250 493.191 Td /F1 9.8 Tf [(1;25\(11\):1422-3. Epub 2009 Mar 20. PubMed PMID: 19304878; PubMed Central PMCID: PMC2682512.)] TJ ET BT 26.250 473.786 Td /F1 9.8 Tf [(10.)] TJ ET BT 43.553 473.786 Td /F1 9.8 Tf [(Edgar RC. MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res. 2004 Mar )] TJ ET BT 26.250 461.881 Td /F1 9.8 Tf [(19;32\(5\):1792-7. Print 2004. PubMed PMID: 15034147; PubMed Central PMCID: PMC390337.)] TJ ET BT 26.250 442.476 Td /F1 9.8 Tf [(11.)] TJ ET BT 43.553 442.476 Td /F1 9.8 Tf [(Han J, Kamber M. Data mining: concepts and techniques. \(Second edition, 2006\). San Francisco: Morgan Kauffman.)] TJ ET BT 26.250 423.072 Td /F1 9.8 Tf [(12.)] TJ ET BT 43.553 423.072 Td /F1 9.8 Tf [(Lombardot T, Kottmann R, Pfeffer H, Richter M, Teeling H, Quast C, Glckner FO. Megx.net--database resources for )] TJ ET BT 26.250 411.167 Td /F1 9.8 Tf [(marine ecological genomics. Nucleic Acids Res. 2006 Jan 1;34\(Database issue\):D390-3. PubMed PMID: 16381894; PubMed )] TJ ET BT 26.250 399.262 Td /F1 9.8 Tf [(Central PMCID: PMC1347433.)] TJ ET BT 26.250 379.857 Td /F1 9.8 Tf [(13.)] TJ ET BT 43.553 379.857 Td /F1 9.8 Tf [(Sheu TG, Deyde VM, Okomo-Adhiambo M, Garten RJ, Xu X, Bright RA, Butler EN, Wallis TR, Klimov AI, Gubareva LV. )] TJ ET BT 26.250 367.953 Td /F1 9.8 Tf [(Surveillance for neuraminidase inhibitor resistance among human influenza A and B viruses circulating worldwide from 2004 to )] TJ ET BT 26.250 356.048 Td /F1 9.8 Tf [(2008. Antimicrob Agents Chemother. 2008 Sep;52\(9\):3284-92. Epub 2008 Jul 14. PubMed PMID: 18625765; PubMed Central )] TJ ET BT 26.250 344.143 Td /F1 9.8 Tf [(PMCID: PMC2533500.)] TJ ET BT 26.250 324.738 Td /F1 9.8 Tf [(14.)] TJ ET BT 43.553 324.738 Td /F1 9.8 Tf [(Garten RJ, Davis CT, Russell CA, Shu B, Lindstrom S, Balish A, Sessions WM, Xu X, Skepner E, Deyde V, Okomo-)] TJ ET BT 26.250 312.834 Td /F1 9.8 Tf [(Adhiambo M, Gubareva L, Barnes J, Smith CB, Emery SL, Hillman MJ, Rivailler P, Smagala J, de Graaf M, Burke DF, Fouchier )] TJ ET BT 26.250 300.929 Td /F1 9.8 Tf [(RA, Pappas C, Alpuche-Aranda CM, Lpez-Gatell H, Olivera H, Lpez I, Myers CA, Faix D, Blair PJ, Yu C, Keene KM, Dotson )] TJ ET BT 26.250 289.024 Td /F1 9.8 Tf [(PD Jr, Boxrud D, Sambol AR, Abid SH, St George K, Bannerman T, Moore AL, Stringer DJ, Blevins P, Demmler-Harrison GJ, )] TJ ET BT 26.250 277.119 Td /F1 9.8 Tf [(Ginsberg M, Kriner P, Waterman S, Smole S, Guevara HF, Belongia EA, Clark PA, Beatrice ST, Donis R, Katz J, Finelli L, )] TJ ET BT 26.250 265.215 Td /F1 9.8 Tf [(Bridges CB, Shaw M, Jernigan DB, Uyeki TM, Smith DJ, Klimov AI, Cox NJ. Antigenic and genetic characteristics of swine-)] TJ ET BT 26.250 253.310 Td /F1 9.8 Tf [(origin 2009 A\(H1N1\) influenza viruses circulating in humans. Science. 2009 Jul 10;325\(5937\):197-201. Epub 2009 May 22. )] TJ ET BT 26.250 241.405 Td /F1 9.8 Tf [(PubMed PMID: 19465683.)] TJ ET BT 26.250 222.000 Td /F1 9.8 Tf [(15.)] TJ ET BT 43.553 222.000 Td /F1 9.8 Tf [(Xu X, Zhu X, Dwek RA, Stevens J, Wilson IA. Structural characterization of the 1918 influenza virus H1N1 neuraminidase. J )] TJ ET BT 26.250 210.096 Td /F1 9.8 Tf [(Virol. 2008 Nov;82\(21\):10493-501. Epub 2008 Aug 20. PubMed PMID: 18715929; PubMed Central PMCID: PMC2573172.)] TJ ET BT 26.250 190.691 Td /F1 9.8 Tf [(16.)] TJ ET BT 43.553 190.691 Td /F1 9.8 Tf [(Stevens J, Corper AL, Basler CF, Taubenberger JK, Palese P, Wilson IA. Structure of the uncleaved human H1 )] TJ ET BT 26.250 178.786 Td /F1 9.8 Tf [(hemagglutinin from the extinct 1918 influenza virus. Science. 2004 Mar 19;303\(5665\):1866-70. Epub 2004 Feb 5. PubMed )] TJ ET BT 26.250 166.881 Td /F1 9.8 Tf [(PMID: 14764887.)] TJ ET BT 26.250 147.477 Td /F1 9.8 Tf [(17.)] TJ ET BT 43.553 147.477 Td /F1 9.8 Tf [(Shih AC, Hsiao TC, Ho MS, Li WH. Simultaneous amino acid substitutions at antigenic sites drive influenza A hemagglutinin )] TJ ET BT 26.250 135.572 Td /F1 9.8 Tf [(evolution. Proc Natl Acad Sci U S A. 2007 Apr 10;104\(15\):6283-8. Epub 2007 Mar 29. PubMed PMID: 17395716; PubMed )] TJ ET BT 26.250 123.667 Td /F1 9.8 Tf [(Central PMCID: PMC1851070.)] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(6)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Influenza)] TJ ET Q endstream endobj xref 0 240 0000000000 65535 f 0000000008 00000 n 0000000073 00000 n 0000000119 00000 n 0000000688 00000 n 0000000725 00000 n 0000000932 00000 n 0000001348 00000 n 0000025085 00000 n 0000025192 00000 n 0000025300 00000 n 0000025411 00000 n 0000025524 00000 n 0000025912 00000 n 0000029744 00000 n 0000029871 00000 n 0000030023 00000 n 0000030150 00000 n 0000030260 00000 n 0000030388 00000 n 0000030495 00000 n 0000030623 00000 n 0000030729 00000 n 0000030857 00000 n 0000030893 00000 n 0000031021 00000 n 0000031057 00000 n 0000031185 00000 n 0000031221 00000 n 0000031349 00000 n 0000031385 00000 n 0000031513 00000 n 0000031549 00000 n 0000031676 00000 n 0000031772 00000 n 0000031900 00000 n 0000031936 00000 n 0000032064 00000 n 0000032140 00000 n 0000032268 00000 n 0000032348 00000 n 0000032476 00000 n 0000032512 00000 n 0000032640 00000 n 0000032676 00000 n 0000032804 00000 n 0000032890 00000 n 0000033017 00000 n 0000033169 00000 n 0000033296 00000 n 0000033406 00000 n 0000033534 00000 n 0000033641 00000 n 0000033769 00000 n 0000033875 00000 n 0000034003 00000 n 0000034039 00000 n 0000034167 00000 n 0000034203 00000 n 0000034331 00000 n 0000034367 00000 n 0000034495 00000 n 0000034531 00000 n 0000034659 00000 n 0000034695 00000 n 0000034822 00000 n 0000034918 00000 n 0000035046 00000 n 0000035082 00000 n 0000035210 00000 n 0000035286 00000 n 0000035414 00000 n 0000035494 00000 n 0000035622 00000 n 0000035658 00000 n 0000035786 00000 n 0000035822 00000 n 0000035950 00000 n 0000036036 00000 n 0000036163 00000 n 0000036315 00000 n 0000036442 00000 n 0000036552 00000 n 0000036680 00000 n 0000036787 00000 n 0000036915 00000 n 0000037021 00000 n 0000037149 00000 n 0000037185 00000 n 0000037313 00000 n 0000037349 00000 n 0000037477 00000 n 0000037513 00000 n 0000037641 00000 n 0000037677 00000 n 0000037805 00000 n 0000037841 00000 n 0000037968 00000 n 0000038064 00000 n 0000038192 00000 n 0000038228 00000 n 0000038358 00000 n 0000038435 00000 n 0000038565 00000 n 0000038646 00000 n 0000038776 00000 n 0000038813 00000 n 0000038943 00000 n 0000038980 00000 n 0000039110 00000 n 0000039197 00000 n 0000039348 00000 n 0000068018 00000 n 0000068148 00000 n 0000068185 00000 n 0000068315 00000 n 0000068352 00000 n 0000068480 00000 n 0000068517 00000 n 0000068647 00000 n 0000068684 00000 n 0000068814 00000 n 0000068851 00000 n 0000068979 00000 n 0000069016 00000 n 0000069146 00000 n 0000069183 00000 n 0000069313 00000 n 0000069350 00000 n 0000069478 00000 n 0000069515 00000 n 0000069666 00000 n 0000085810 00000 n 0000085940 00000 n 0000086012 00000 n 0000086142 00000 n 0000086179 00000 n 0000086308 00000 n 0000086429 00000 n 0000087288 00000 n 0000184965 00000 n 0000185095 00000 n 0000185167 00000 n 0000185297 00000 n 0000185334 00000 n 0000185463 00000 n 0000185584 00000 n 0000186443 00000 n 0000284120 00000 n 0000284250 00000 n 0000284322 00000 n 0000284452 00000 n 0000284489 00000 n 0000284618 00000 n 0000284739 00000 n 0000285598 00000 n 0000383275 00000 n 0000384134 00000 n 0000481811 00000 n 0000481938 00000 n 0000498373 00000 n 0000498502 00000 n 0000498625 00000 n 0000499425 00000 n 0000555531 00000 n 0000555659 00000 n 0000555696 00000 n 0000555825 00000 n 0000555948 00000 n 0000556748 00000 n 0000612854 00000 n 0000612982 00000 n 0000613019 00000 n 0000613148 00000 n 0000613271 00000 n 0000614071 00000 n 0000670177 00000 n 0000670305 00000 n 0000670342 00000 n 0000671142 00000 n 0000727248 00000 n 0000727519 00000 n 0000741338 00000 n 0000741467 00000 n 0000741578 00000 n 0000742378 00000 n 0000822280 00000 n 0000822410 00000 n 0000822447 00000 n 0000822577 00000 n 0000822614 00000 n 0000822744 00000 n 0000822781 00000 n 0000822911 00000 n 0000822948 00000 n 0000823078 00000 n 0000823115 00000 n 0000823245 00000 n 0000823282 00000 n 0000823412 00000 n 0000823449 00000 n 0000823578 00000 n 0000823689 00000 n 0000824489 00000 n 0000904391 00000 n 0000904521 00000 n 0000904558 00000 n 0000904688 00000 n 0000904725 00000 n 0000904855 00000 n 0000904892 00000 n 0000905022 00000 n 0000905059 00000 n 0000905189 00000 n 0000905226 00000 n 0000905356 00000 n 0000905393 00000 n 0000905523 00000 n 0000905560 00000 n 0000905689 00000 n 0000905800 00000 n 0000906600 00000 n 0000986502 00000 n 0000986632 00000 n 0000986669 00000 n 0000986799 00000 n 0000986836 00000 n 0000986966 00000 n 0000987003 00000 n 0000987133 00000 n 0000987170 00000 n 0000987300 00000 n 0000987337 00000 n 0000987467 00000 n 0000987504 00000 n 0000987634 00000 n 0000987671 00000 n 0000988471 00000 n 0001068373 00000 n 0001068440 00000 n trailer << /Size 240 /Root 1 0 R /Info 5 0 R >> startxref 1089802 %%EOF