%PDF-1.3 1 0 obj << /Type /Catalog /Outlines 2 0 R /Pages 3 0 R >> endobj 2 0 obj << /Type /Outlines /Count 0 >> endobj 3 0 obj << /Type /Pages /Kids [6 0 R 63 0 R 78 0 R 100 0 R 116 0 R 145 0 R 167 0 R 196 0 R ] /Count 8 /Resources << /ProcSet 4 0 R /Font << /F1 8 0 R /F2 9 0 R /F3 10 0 R /F4 11 0 R /F5 12 0 R >> /XObject << /I1 13 0 R /I2 14 0 R /I3 65 0 R /I4 66 0 R /I5 69 0 R /I6 70 0 R /I7 71 0 R /I8 74 0 R /I9 75 0 R /I10 82 0 R /I11 85 0 R /I12 86 0 R /I13 87 0 R /I14 92 0 R /I15 93 0 R /I16 98 0 R /I17 99 0 R /I18 104 0 R /I19 107 0 R /I20 120 0 R /I21 123 0 R /I22 128 0 R /I23 149 0 R /I24 152 0 R /I25 171 0 R /I26 176 0 R /I27 179 0 R /I28 198 0 R >> >> /MediaBox [0.000 0.000 612.000 792.000] >> endobj 4 0 obj [/PDF /Text /ImageC ] endobj 5 0 obj << /Creator (DOMPDF) /CreationDate (D:20170829204030+00'00') /ModDate (D:20170829204030+00'00') /Title (DuchenneConnect Registry Report PLOS Currents Muscular Dystrophy) >> endobj 6 0 obj << /Type /Page /Parent 3 0 R /Annots [ 15 0 R 17 0 R 19 0 R 21 0 R 23 0 R 25 0 R 27 0 R 29 0 R 31 0 R 33 0 R 35 0 R 37 0 R 39 0 R 41 0 R 43 0 R 45 0 R 47 0 R 49 0 R 51 0 R 53 0 R 55 0 R 57 0 R 59 0 R 61 0 R ] /Contents 7 0 R >> endobj 7 0 obj << /Length 19859 >> stream q 375.000 0 0 39.000 222.000 738.000 cm /I2 Do Q q 15.000 709.302 577.500 28.698 re W n 0.267 0.267 0.267 rg BT 15.000 718.042 Td /F2 21.0 Tf [(DuchenneConnect Registry Report)] TJ ET Q 0.271 0.267 0.267 rg BT 15.000 700.036 Td /F3 9.8 Tf [(March 5, 2012)] TJ ET BT 77.556 700.036 Td /F3 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg BT 82.431 700.036 Td /F3 9.8 Tf [(Epidemiology and Patient Registries)] TJ ET BT 26.250 688.195 Td /F1 9.8 Tf [(Vanessa Rangel)] TJ ET 0.271 0.267 0.267 rg BT 97.786 688.195 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 103.207 688.195 Td /F1 9.8 Tf [(Anne S. Martin)] TJ ET 0.271 0.267 0.267 rg BT 167.693 688.195 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 173.114 688.195 Td /F1 9.8 Tf [(Holly L. Peay)] TJ ET 0.271 0.267 0.267 rg BT 26.250 676.290 Td /F1 9.8 Tf [(Rangel V, Martin AS, Peay HL. DuchenneConnect Registry Report. PLOS Currents Muscular Dystrophy. 2012 Mar 5 . Edition )] TJ ET BT 569.754 676.290 Td /F1 9.8 Tf [(1. )] TJ ET BT 26.250 664.386 Td /F1 9.8 Tf [(doi: 10.1371/currents.RRN1309.)] TJ ET q 15.000 32.197 577.500 629.807 re W n 0.271 0.267 0.267 rg BT 26.250 635.283 Td /F4 12.0 Tf [(Abstract)] TJ ET BT 26.250 615.329 Td /F1 9.8 Tf [(Research activity in Duchenne/Becker muscular dystrophy has surged in recent years, requiring robust information networks to )] TJ ET BT 26.250 603.424 Td /F1 9.8 Tf [(support ongoing development. Established by Parent Project Muscular Dystrophy in late 2007, DuchenneConnect was created )] TJ ET BT 26.250 591.519 Td /F1 9.8 Tf [(to bridge the information gap between care providers, researchers and the patient community, thereby addressing medical care )] TJ ET BT 26.250 579.615 Td /F1 9.8 Tf [(needs and accelerating the pace of therapeutic advancements. This report represents the first in a new series that will be )] TJ ET BT 26.250 567.710 Td /F1 9.8 Tf [(regularly shared by DuchenneConnect and PPMD. Data in this report was collected through June 2011.)] TJ ET BT 26.250 531.107 Td /F4 12.0 Tf [(Funding Statement)] TJ ET BT 26.250 511.153 Td /F1 9.8 Tf [(DuchenneConnect is supported by Parent Project Muscular Dystrophy.)] TJ ET BT 26.250 482.051 Td /F4 12.0 Tf [(Background)] TJ ET BT 26.250 462.096 Td /F1 9.8 Tf [(Research activity in Duchenne and Becker muscular dystrophy \(DBMD\) has surged in recent years, requiring robust information )] TJ ET BT 26.250 450.192 Td /F1 9.8 Tf [(networks to support therapeutic development. As of November 2011, Clinicaltrials.gov lists more than 10 active clinical trials in )] TJ ET BT 26.250 438.287 Td /F1 9.8 Tf [(DBMD \(www.clinicaltrials.gov\). In addition, the publication in 2010 of care recommendations for Duchenne \()] TJ ET 0.267 0.267 0.267 rg BT 489.541 438.287 Td /F1 9.8 Tf [([1][2])] TJ ET 0.271 0.267 0.267 rg BT 511.225 438.287 Td /F1 9.8 Tf [(\) marked a )] TJ ET BT 26.250 426.382 Td /F1 9.8 Tf [(watershed moment for families affected by and clinicians caring for individuals with DBMD.)] TJ ET BT 26.250 406.977 Td /F1 9.8 Tf [(This recent progress makes close communication between stakeholders in the DBMD community even more vital, e.g., to )] TJ ET BT 26.250 395.073 Td /F1 9.8 Tf [(disseminate and educate about care recommendations, provide feasibility data to researchers and industry, collect natural )] TJ ET BT 26.250 383.168 Td /F1 9.8 Tf [(history data, and facilitate recruitment into research studies. Established by Parent Project Muscular Dystrophy in late 2007, )] TJ ET BT 26.250 371.263 Td /F1 9.8 Tf [(DuchenneConnect was created to bridge the information gap between care providers, researchers and the patient community, )] TJ ET BT 26.250 359.358 Td /F1 9.8 Tf [(thereby addressing medical care needs and accelerating the pace of therapeutic advancements.)] TJ ET BT 26.250 322.756 Td /F4 12.0 Tf [(The Registry Model)] TJ ET BT 26.250 302.802 Td /F1 9.8 Tf [(The registry model \(as described by PatientCrossroads, )] TJ ET 0.267 0.267 0.267 rg BT 269.542 302.802 Td /F1 9.8 Tf [(www.patientcrossroads.com)] TJ ET 0.271 0.267 0.267 rg BT 391.446 302.802 Td /F1 9.8 Tf [(\) describes an ideal registry process; this )] TJ ET BT 26.250 290.897 Td /F1 9.8 Tf [(model is consistent with and in part informed by the DuchenneConnect registry.)] TJ ET BT 26.250 271.492 Td /F5 9.8 Tf [(Foundations or institutions)] TJ ET BT 152.464 271.492 Td /F1 9.8 Tf [( sponsor registries, acting as the trusted gatekeeper.)] TJ ET BT 26.250 252.087 Td /F5 9.8 Tf [(Patients)] TJ ET BT 64.178 252.087 Td /F1 9.8 Tf [( register and provide detailed information about their health history.)] TJ ET BT 26.250 232.683 Td /F5 9.8 Tf [(Coordinators)] TJ ET BT 87.460 232.683 Td /F1 9.8 Tf [( curate patient data, answer questions, and assist with participation.)] TJ ET BT 26.250 213.278 Td /F5 9.8 Tf [(Clinicians/Researchers)] TJ ET BT 133.549 213.278 Td /F1 9.8 Tf [( have access to aggregated, de-identified patient data which serves as pilot data, to develop research )] TJ ET BT 26.250 201.373 Td /F1 9.8 Tf [(ideas, and to answer specific research questions.)] TJ ET BT 26.250 181.968 Td /F5 9.8 Tf [(Industry)] TJ ET BT 64.714 181.968 Td /F1 9.8 Tf [( uses the de-identified patient data for study planning and pre-screening for enrollment.)] TJ ET BT 26.250 145.366 Td /F4 12.0 Tf [(Duchenne Connect Registry)] TJ ET BT 26.250 125.412 Td /F1 9.8 Tf [(DuchenneConnect is a patient-report registry and educational resource for individuals with Duchenne and Becker muscular )] TJ ET BT 26.250 113.507 Td /F1 9.8 Tf [(dystrophy, carrier females, and families of affected individuals. The registry can be accessed at )] TJ ET 0.267 0.267 0.267 rg BT 438.626 113.507 Td /F1 9.8 Tf [(www.duchenneconnect.org)] TJ ET 0.271 0.267 0.267 rg BT 556.221 113.507 Td /F1 9.8 Tf [(. )] TJ ET BT 26.250 101.602 Td /F1 9.8 Tf [(Clinicians and researchers have been informed about the registry through presentations at professional and advocacy )] TJ ET BT 26.250 89.697 Td /F1 9.8 Tf [(conferences, targeted communications, and online outreach efforts. Affected individuals and families are often informed about )] TJ ET BT 26.250 77.793 Td /F1 9.8 Tf [(the registry by clinicians or learn about it through advocacy organizations.)] TJ ET BT 26.250 58.388 Td /F1 9.8 Tf [(Registry data is entered by parents/guardians of affected individuals, individuals with DBMD, and rarely by healthcare providers. )] TJ ET BT 26.250 46.483 Td /F1 9.8 Tf [(Each participants data is accessed through a unique ID and password, which maintains security and allows participants to )] TJ ET Q q 15.000 709.302 577.500 28.698 re W n 0.267 0.267 0.267 rg BT 15.000 718.042 Td /F2 21.0 Tf [(DuchenneConnect Registry Report)] TJ ET Q 0.271 0.267 0.267 rg BT 15.000 700.036 Td /F3 9.8 Tf [(March 5, 2012)] TJ ET BT 77.556 700.036 Td /F3 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg BT 82.431 700.036 Td /F3 9.8 Tf [(Epidemiology and Patient Registries)] TJ ET BT 26.250 688.195 Td /F1 9.8 Tf [(Vanessa Rangel)] TJ ET 0.271 0.267 0.267 rg BT 97.786 688.195 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 103.207 688.195 Td /F1 9.8 Tf [(Anne S. Martin)] TJ ET 0.271 0.267 0.267 rg BT 167.693 688.195 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 173.114 688.195 Td /F1 9.8 Tf [(Holly L. Peay)] TJ ET 0.271 0.267 0.267 rg BT 26.250 676.290 Td /F1 9.8 Tf [(Rangel V, Martin AS, Peay HL. DuchenneConnect Registry Report. PLOS Currents Muscular Dystrophy. 2012 Mar 5 . Edition )] TJ ET BT 569.754 676.290 Td /F1 9.8 Tf [(1. )] TJ ET BT 26.250 664.386 Td /F1 9.8 Tf [(doi: 10.1371/currents.RRN1309.)] TJ ET q 15.000 32.197 577.500 629.807 re W n 0.271 0.267 0.267 rg BT 26.250 635.283 Td /F4 12.0 Tf [(Abstract)] TJ ET BT 26.250 615.329 Td /F1 9.8 Tf [(Research activity in Duchenne/Becker muscular dystrophy has surged in recent years, requiring robust information networks to )] TJ ET BT 26.250 603.424 Td /F1 9.8 Tf [(support ongoing development. Established by Parent Project Muscular Dystrophy in late 2007, DuchenneConnect was created )] TJ ET BT 26.250 591.519 Td /F1 9.8 Tf [(to bridge the information gap between care providers, researchers and the patient community, thereby addressing medical care )] TJ ET BT 26.250 579.615 Td /F1 9.8 Tf [(needs and accelerating the pace of therapeutic advancements. This report represents the first in a new series that will be )] TJ ET BT 26.250 567.710 Td /F1 9.8 Tf [(regularly shared by DuchenneConnect and PPMD. Data in this report was collected through June 2011.)] TJ ET BT 26.250 531.107 Td /F4 12.0 Tf [(Funding Statement)] TJ ET BT 26.250 511.153 Td /F1 9.8 Tf [(DuchenneConnect is supported by Parent Project Muscular Dystrophy.)] TJ ET BT 26.250 482.051 Td /F4 12.0 Tf [(Background)] TJ ET BT 26.250 462.096 Td /F1 9.8 Tf [(Research activity in Duchenne and Becker muscular dystrophy \(DBMD\) has surged in recent years, requiring robust information )] TJ ET BT 26.250 450.192 Td /F1 9.8 Tf [(networks to support therapeutic development. As of November 2011, Clinicaltrials.gov lists more than 10 active clinical trials in )] TJ ET BT 26.250 438.287 Td /F1 9.8 Tf [(DBMD \(www.clinicaltrials.gov\). In addition, the publication in 2010 of care recommendations for Duchenne \()] TJ ET 0.267 0.267 0.267 rg BT 489.541 438.287 Td /F1 9.8 Tf [([1][2])] TJ ET 0.271 0.267 0.267 rg BT 511.225 438.287 Td /F1 9.8 Tf [(\) marked a )] TJ ET BT 26.250 426.382 Td /F1 9.8 Tf [(watershed moment for families affected by and clinicians caring for individuals with DBMD.)] TJ ET BT 26.250 406.977 Td /F1 9.8 Tf [(This recent progress makes close communication between stakeholders in the DBMD community even more vital, e.g., to )] TJ ET BT 26.250 395.073 Td /F1 9.8 Tf [(disseminate and educate about care recommendations, provide feasibility data to researchers and industry, collect natural )] TJ ET BT 26.250 383.168 Td /F1 9.8 Tf [(history data, and facilitate recruitment into research studies. Established by Parent Project Muscular Dystrophy in late 2007, )] TJ ET BT 26.250 371.263 Td /F1 9.8 Tf [(DuchenneConnect was created to bridge the information gap between care providers, researchers and the patient community, )] TJ ET BT 26.250 359.358 Td /F1 9.8 Tf [(thereby addressing medical care needs and accelerating the pace of therapeutic advancements.)] TJ ET BT 26.250 322.756 Td /F4 12.0 Tf [(The Registry Model)] TJ ET BT 26.250 302.802 Td /F1 9.8 Tf [(The registry model \(as described by PatientCrossroads, )] TJ ET 0.267 0.267 0.267 rg BT 269.542 302.802 Td /F1 9.8 Tf [(www.patientcrossroads.com)] TJ ET 0.271 0.267 0.267 rg BT 391.446 302.802 Td /F1 9.8 Tf [(\) describes an ideal registry process; this )] TJ ET BT 26.250 290.897 Td /F1 9.8 Tf [(model is consistent with and in part informed by the DuchenneConnect registry.)] TJ ET BT 26.250 271.492 Td /F5 9.8 Tf [(Foundations or institutions)] TJ ET BT 152.464 271.492 Td /F1 9.8 Tf [( sponsor registries, acting as the trusted gatekeeper.)] TJ ET BT 26.250 252.087 Td /F5 9.8 Tf [(Patients)] TJ ET BT 64.178 252.087 Td /F1 9.8 Tf [( register and provide detailed information about their health history.)] TJ ET BT 26.250 232.683 Td /F5 9.8 Tf [(Coordinators)] TJ ET BT 87.460 232.683 Td /F1 9.8 Tf [( curate patient data, answer questions, and assist with participation.)] TJ ET BT 26.250 213.278 Td /F5 9.8 Tf [(Clinicians/Researchers)] TJ ET BT 133.549 213.278 Td /F1 9.8 Tf [( have access to aggregated, de-identified patient data which serves as pilot data, to develop research )] TJ ET BT 26.250 201.373 Td /F1 9.8 Tf [(ideas, and to answer specific research questions.)] TJ ET BT 26.250 181.968 Td /F5 9.8 Tf [(Industry)] TJ ET BT 64.714 181.968 Td /F1 9.8 Tf [( uses the de-identified patient data for study planning and pre-screening for enrollment.)] TJ ET BT 26.250 145.366 Td /F4 12.0 Tf [(Duchenne Connect Registry)] TJ ET BT 26.250 125.412 Td /F1 9.8 Tf [(DuchenneConnect is a patient-report registry and educational resource for individuals with Duchenne and Becker muscular )] TJ ET BT 26.250 113.507 Td /F1 9.8 Tf [(dystrophy, carrier females, and families of affected individuals. The registry can be accessed at )] TJ ET 0.267 0.267 0.267 rg BT 438.626 113.507 Td /F1 9.8 Tf [(www.duchenneconnect.org)] TJ ET 0.271 0.267 0.267 rg BT 556.221 113.507 Td /F1 9.8 Tf [(. )] TJ ET BT 26.250 101.602 Td /F1 9.8 Tf [(Clinicians and researchers have been informed about the registry through presentations at professional and advocacy )] TJ ET BT 26.250 89.697 Td /F1 9.8 Tf [(conferences, targeted communications, and online outreach efforts. Affected individuals and families are often informed about )] TJ ET BT 26.250 77.793 Td /F1 9.8 Tf [(the registry by clinicians or learn about it through advocacy organizations.)] TJ ET BT 26.250 58.388 Td /F1 9.8 Tf [(Registry data is entered by parents/guardians of affected individuals, individuals with DBMD, and rarely by healthcare providers. )] TJ ET BT 26.250 46.483 Td /F1 9.8 Tf [(Each participants data is accessed through a unique ID and password, which maintains security and allows participants to )] TJ ET Q q 15.000 709.302 577.500 28.698 re W n 0.267 0.267 0.267 rg BT 15.000 718.042 Td /F2 21.0 Tf [(DuchenneConnect Registry Report)] TJ ET Q 0.271 0.267 0.267 rg BT 15.000 700.036 Td /F3 9.8 Tf [(March 5, 2012)] TJ ET BT 77.556 700.036 Td /F3 9.8 Tf [()] TJ ET 0.267 0.267 0.267 rg BT 82.431 700.036 Td /F3 9.8 Tf [(Epidemiology and Patient Registries)] TJ ET BT 26.250 688.195 Td /F1 9.8 Tf [(Vanessa Rangel)] TJ ET 0.271 0.267 0.267 rg BT 97.786 688.195 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 103.207 688.195 Td /F1 9.8 Tf [(Anne S. Martin)] TJ ET 0.271 0.267 0.267 rg BT 167.693 688.195 Td /F1 9.8 Tf [(, )] TJ ET 0.267 0.267 0.267 rg BT 173.114 688.195 Td /F1 9.8 Tf [(Holly L. Peay)] TJ ET 0.271 0.267 0.267 rg BT 26.250 676.290 Td /F1 9.8 Tf [(Rangel V, Martin AS, Peay HL. DuchenneConnect Registry Report. PLOS Currents Muscular Dystrophy. 2012 Mar 5 . Edition )] TJ ET BT 569.754 676.290 Td /F1 9.8 Tf [(1. )] TJ ET BT 26.250 664.386 Td /F1 9.8 Tf [(doi: 10.1371/currents.RRN1309.)] TJ ET q 15.000 32.197 577.500 629.807 re W n 0.271 0.267 0.267 rg BT 26.250 635.283 Td /F4 12.0 Tf [(Abstract)] TJ ET BT 26.250 615.329 Td /F1 9.8 Tf [(Research activity in Duchenne/Becker muscular dystrophy has surged in recent years, requiring robust information networks to )] TJ ET BT 26.250 603.424 Td /F1 9.8 Tf [(support ongoing development. Established by Parent Project Muscular Dystrophy in late 2007, DuchenneConnect was created )] TJ ET BT 26.250 591.519 Td /F1 9.8 Tf [(to bridge the information gap between care providers, researchers and the patient community, thereby addressing medical care )] TJ ET BT 26.250 579.615 Td /F1 9.8 Tf [(needs and accelerating the pace of therapeutic advancements. This report represents the first in a new series that will be )] TJ ET BT 26.250 567.710 Td /F1 9.8 Tf [(regularly shared by DuchenneConnect and PPMD. Data in this report was collected through June 2011.)] TJ ET BT 26.250 531.107 Td /F4 12.0 Tf [(Funding Statement)] TJ ET BT 26.250 511.153 Td /F1 9.8 Tf [(DuchenneConnect is supported by Parent Project Muscular Dystrophy.)] TJ ET BT 26.250 482.051 Td /F4 12.0 Tf [(Background)] TJ ET BT 26.250 462.096 Td /F1 9.8 Tf [(Research activity in Duchenne and Becker muscular dystrophy \(DBMD\) has surged in recent years, requiring robust information )] TJ ET BT 26.250 450.192 Td /F1 9.8 Tf [(networks to support therapeutic development. As of November 2011, Clinicaltrials.gov lists more than 10 active clinical trials in )] TJ ET BT 26.250 438.287 Td /F1 9.8 Tf [(DBMD \(www.clinicaltrials.gov\). In addition, the publication in 2010 of care recommendations for Duchenne \()] TJ ET 0.267 0.267 0.267 rg BT 489.541 438.287 Td /F1 9.8 Tf [([1][2])] TJ ET 0.271 0.267 0.267 rg BT 511.225 438.287 Td /F1 9.8 Tf [(\) marked a )] TJ ET BT 26.250 426.382 Td /F1 9.8 Tf [(watershed moment for families affected by and clinicians caring for individuals with DBMD.)] TJ ET BT 26.250 406.977 Td /F1 9.8 Tf [(This recent progress makes close communication between stakeholders in the DBMD community even more vital, e.g., to )] TJ ET BT 26.250 395.073 Td /F1 9.8 Tf [(disseminate and educate about care recommendations, provide feasibility data to researchers and industry, collect natural )] TJ ET BT 26.250 383.168 Td /F1 9.8 Tf [(history data, and facilitate recruitment into research studies. Established by Parent Project Muscular Dystrophy in late 2007, )] TJ ET BT 26.250 371.263 Td /F1 9.8 Tf [(DuchenneConnect was created to bridge the information gap between care providers, researchers and the patient community, )] TJ ET BT 26.250 359.358 Td /F1 9.8 Tf [(thereby addressing medical care needs and accelerating the pace of therapeutic advancements.)] TJ ET BT 26.250 322.756 Td /F4 12.0 Tf [(The Registry Model)] TJ ET BT 26.250 302.802 Td /F1 9.8 Tf [(The registry model \(as described by PatientCrossroads, )] TJ ET 0.267 0.267 0.267 rg BT 269.542 302.802 Td /F1 9.8 Tf [(www.patientcrossroads.com)] TJ ET 0.271 0.267 0.267 rg BT 391.446 302.802 Td /F1 9.8 Tf [(\) describes an ideal registry process; this )] TJ ET BT 26.250 290.897 Td /F1 9.8 Tf [(model is consistent with and in part informed by the DuchenneConnect registry.)] TJ ET BT 26.250 271.492 Td /F5 9.8 Tf [(Foundations or institutions)] TJ ET BT 152.464 271.492 Td /F1 9.8 Tf [( sponsor registries, acting as the trusted gatekeeper.)] TJ ET BT 26.250 252.087 Td /F5 9.8 Tf [(Patients)] TJ ET BT 64.178 252.087 Td /F1 9.8 Tf [( register and provide detailed information about their health history.)] TJ ET BT 26.250 232.683 Td /F5 9.8 Tf [(Coordinators)] TJ ET BT 87.460 232.683 Td /F1 9.8 Tf [( curate patient data, answer questions, and assist with participation.)] TJ ET BT 26.250 213.278 Td /F5 9.8 Tf [(Clinicians/Researchers)] TJ ET BT 133.549 213.278 Td /F1 9.8 Tf [( have access to aggregated, de-identified patient data which serves as pilot data, to develop research )] TJ ET BT 26.250 201.373 Td /F1 9.8 Tf [(ideas, and to answer specific research questions.)] TJ ET BT 26.250 181.968 Td /F5 9.8 Tf [(Industry)] TJ ET BT 64.714 181.968 Td /F1 9.8 Tf [( uses the de-identified patient data for study planning and pre-screening for enrollment.)] TJ ET BT 26.250 145.366 Td /F4 12.0 Tf [(Duchenne Connect Registry)] TJ ET BT 26.250 125.412 Td /F1 9.8 Tf [(DuchenneConnect is a patient-report registry and educational resource for individuals with Duchenne and Becker muscular )] TJ ET BT 26.250 113.507 Td /F1 9.8 Tf [(dystrophy, carrier females, and families of affected individuals. The registry can be accessed at )] TJ ET 0.267 0.267 0.267 rg BT 438.626 113.507 Td /F1 9.8 Tf [(www.duchenneconnect.org)] TJ ET 0.271 0.267 0.267 rg BT 556.221 113.507 Td /F1 9.8 Tf [(. )] TJ ET BT 26.250 101.602 Td /F1 9.8 Tf [(Clinicians and researchers have been informed about the registry through presentations at professional and advocacy )] TJ ET BT 26.250 89.697 Td /F1 9.8 Tf [(conferences, targeted communications, and online outreach efforts. Affected individuals and families are often informed about )] TJ ET BT 26.250 77.793 Td /F1 9.8 Tf [(the registry by clinicians or learn about it through advocacy organizations.)] TJ ET BT 26.250 58.388 Td /F1 9.8 Tf [(Registry data is entered by parents/guardians of affected individuals, individuals with DBMD, and rarely by healthcare providers. )] TJ ET BT 26.250 46.483 Td /F1 9.8 Tf [(Each participants data is accessed through a unique ID and password, which maintains security and allows participants to )] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(1)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Muscular Dystrophy)] TJ ET Q endstream endobj 8 0 obj << /Type /Font /Subtype /Type1 /Name /F1 /BaseFont /Helvetica /Encoding /WinAnsiEncoding >> endobj 9 0 obj << /Type /Font /Subtype /Type1 /Name /F2 /BaseFont /Times-Bold /Encoding /WinAnsiEncoding >> endobj 10 0 obj << /Type /Font /Subtype /Type1 /Name /F3 /BaseFont /Times-Italic /Encoding /WinAnsiEncoding >> endobj 11 0 obj << /Type /Font /Subtype /Type1 /Name /F4 /BaseFont /Helvetica-Bold /Encoding /WinAnsiEncoding >> endobj 12 0 obj << /Type /Font /Subtype /Type1 /Name /F5 /BaseFont /Helvetica-BoldOblique /Encoding /WinAnsiEncoding >> endobj 13 0 obj << /Type /XObject /Subtype /Image /Width 500 /Height 52 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 500 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 144>> stream x1 0 'ݲ؎"e{dzAdzAdzAdzAdzAdzAdzAdzAdzAdzAdzAdzAtlM0\ endstream endobj 14 0 obj << /Type /XObject /Subtype /Image /Width 500 /Height 52 /SMask 13 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 500 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 4099>> stream xݙ,`qG8`Gv#;3dUggzB R4A0 0} 0 0ŝa0 ym۶3danangl6;ʓa{; 0(Mӯ_ !Id2LOFQu]׵"mN$I$Nܯdw0̯Y=if\.7_`ZŦrysV 0'֞=t<0 `qlwqK۶aESY& C%p8( Eї/_4'r9ooor( X:ƊD///7 â(EUUё9VAeYoooEjy*7FhvTU%rY.AumC c`,rkN'ϻ ðklV4#)MȲ ,KwEahтN'㵨(B1166YDQDy*%QA 4^r(|*a~[.#Oay4eY ! k PV\EQɘ?}Ⱥc;*q7j ʲeߣTΈ BYYzm=c<&jy!EQШyR@ = Ȋup02ʁRe4 F wa0.UU ծgt^{}GܻH40 ޝȸ B t]aw/GIGHK=O;)% :3iÿ,W x~~ -X.H#g| fh,MAf&sBa8ݧ~Շ8n 5߻ |6᚞;fi! p0$ [=\]DUe}y2 n :niuQ;yt( : deF]U(s ?Ɵ |J׆τjrã'PU'k#8;Gog?aX{4_*Ou]Xӭ8*/F>le MmݡAa Y.1!9 |xosG(c59u6w q7l+|F ah%Pa;N(H?yTgjrL(ήlf4FOJYe#Ƚ`jʲLӔODƔ[Y)O**q7zROV- wM\+aXɘQuԷn˻:}(Ċ]F͟Rqт*)7~*'@ܯx ÝG Y&cj?usJ9zaoHbTSߘ+ eB eu6o6%U4xXX 0:}3ZaeYeQavS]sf+~ "&8]/Rjڑ+a~c[|̊"c8 "rۡۨX4׊QG] c?,pqʚ1UUs;NM(G#Y䯠j>Sd 0\|E5/f:B}kݘ^j`K%gP3<: 06؉m|޶-֧ vpn \?.3+ނhV6I^0̏WiE"hݸx<;Z=9<tgڶe}gw=:$ S= "0 ,C{0eXl6{v툢ȧ|# &;hv^q-=!?n!}>*s" !4]@4BR)iީRs)q=TǘEt9vkl6*!څ~ZGڶU`˥޶l6C$I?>WIıgl63L5. 'I\.S.K$ʅ˥}X,&ɟAJ$_8<~ZMSl+eX,JDITjR qXWa>3FK<*C{򟣠ARvPߴWHNjO<-hӆU'rG +iન8ELkcl"W)^b*B3E4xF(=~P*$MSPr9DQ$G6ų( u1*{i4U_RX4.{+T3^k> c*;>]9&nP;Ou/kC"0>QTKp#qv]hǺtRVH#2 @C;2r\|>NzayˋE zW/uRc> Ct!7a#~/txzXLSJûY{ d6J 0%6}d m_iepji> &%%o(k2=ġ]0|~~5)ò0 -)DZMb!nnYrl6kw`>=Ty"taxͲLu !]: AkOXV.Mӧ'!Doooznd~}}fYA"7wvBV˲4ݔe$t:MCxA,WRX9lce1gfa4Qmq?)Yy`jݰl/BHri!DG^0uyQ>$P7Y{Lg;ж'J]F_cY8v@L9ގfq Ӝjr@p巉;?MS[g<8u2ު'ۣ,34E>PUz"bsYi=;*Hp;˲kF$O80a[Y<= зQￋX,M=Bto'6 fQlOOO6fq ˗/ϓ5i٘(K|_YU xQ=wp:t4cw؆O g=iZ(æ 5d_v(繾ob4rA9b,CV@=6O6;a +徰lQ¯TyO[9h7񠞻|x೤\phq$艊A>҇,˪A4NQ%+W0.˲|*u]WAIJP\"Spa@bŝ6~E>:Am4eYîgX붳9N=E!, 0  endstream endobj 15 0 obj << /Type /Annot /Subtype /Link /A 16 0 R /Border [0 0 0] /H /I /Rect [ 15.0000 716.1516 328.7820 736.9416 ] >> endobj 16 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/article/duchenneconnect-registry-report/) >> endobj 17 0 obj << /Type /Annot /Subtype /Link /A 18 0 R /Border [0 0 0] /H /I /Rect [ 82.4310 699.1581 225.6975 708.8106 ] >> endobj 18 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/article_category/epidemiology-and-patient-registries/) >> endobj 19 0 obj << /Type /Annot /Subtype /Link /A 20 0 R /Border [0 0 0] /H /I /Rect [ 26.2500 687.2933 97.7857 697.2140 ] >> endobj 20 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/author/vanessarangel/) >> endobj 21 0 obj << /Type /Annot /Subtype /Link /A 22 0 R /Border [0 0 0] /H /I /Rect [ 103.2067 687.2933 167.6933 697.2140 ] >> endobj 22 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/author/annesmartin/) >> endobj 23 0 obj << /Type /Annot /Subtype /Link /A 24 0 R /Border [0 0 0] /H /I /Rect [ 173.1142 687.2933 230.5515 697.2140 ] >> endobj 24 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/author/hollylpeay/) >> endobj 25 0 obj << /Type /Annot /Subtype /Link /A 26 0 R /Border [0 0 0] /H /I /Rect [ 489.5408 437.3851 511.2248 447.3057 ] >> endobj 26 0 obj << /Type /Action /S /URI /URI (http://@references) >> endobj 27 0 obj << /Type /Annot /Subtype /Link /A 28 0 R /Border [0 0 0] /H /I /Rect [ 269.5417 301.8998 391.4460 311.8205 ] >> endobj 28 0 obj << /Type /Action /S /URI /URI (http://www.patientcrossroads.com) >> endobj 29 0 obj << /Type /Annot /Subtype /Link /A 30 0 R /Border [0 0 0] /H /I /Rect [ 438.6263 112.6051 556.2210 122.5257 ] >> endobj 30 0 obj << /Type /Action /S /URI /URI (http://www.duchenneconnect.org) >> endobj 31 0 obj << /Type /Annot /Subtype /Link /A 32 0 R /Border [0 0 0] /H /I /Rect [ 15.0000 716.1516 328.7820 736.9416 ] >> endobj 32 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/article/duchenneconnect-registry-report/) >> endobj 33 0 obj << /Type /Annot /Subtype /Link /A 34 0 R /Border [0 0 0] /H /I /Rect [ 82.4310 699.1581 225.6975 708.8106 ] >> endobj 34 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/article_category/epidemiology-and-patient-registries/) >> endobj 35 0 obj << /Type /Annot /Subtype /Link /A 36 0 R /Border [0 0 0] /H /I /Rect [ 26.2500 687.2933 97.7857 697.2140 ] >> endobj 36 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/author/vanessarangel/) >> endobj 37 0 obj << /Type /Annot /Subtype /Link /A 38 0 R /Border [0 0 0] /H /I /Rect [ 103.2067 687.2933 167.6933 697.2140 ] >> endobj 38 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/author/annesmartin/) >> endobj 39 0 obj << /Type /Annot /Subtype /Link /A 40 0 R /Border [0 0 0] /H /I /Rect [ 173.1142 687.2933 230.5515 697.2140 ] >> endobj 40 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/author/hollylpeay/) >> endobj 41 0 obj << /Type /Annot /Subtype /Link /A 42 0 R /Border [0 0 0] /H /I /Rect [ 489.5408 437.3851 511.2248 447.3057 ] >> endobj 42 0 obj << /Type /Action /S /URI /URI (http://@references) >> endobj 43 0 obj << /Type /Annot /Subtype /Link /A 44 0 R /Border [0 0 0] /H /I /Rect [ 269.5417 301.8998 391.4460 311.8205 ] >> endobj 44 0 obj << /Type /Action /S /URI /URI (http://www.patientcrossroads.com) >> endobj 45 0 obj << /Type /Annot /Subtype /Link /A 46 0 R /Border [0 0 0] /H /I /Rect [ 438.6263 112.6051 556.2210 122.5257 ] >> endobj 46 0 obj << /Type /Action /S /URI /URI (http://www.duchenneconnect.org) >> endobj 47 0 obj << /Type /Annot /Subtype /Link /A 48 0 R /Border [0 0 0] /H /I /Rect [ 15.0000 716.1516 328.7820 736.9416 ] >> endobj 48 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/article/duchenneconnect-registry-report/) >> endobj 49 0 obj << /Type /Annot /Subtype /Link /A 50 0 R /Border [0 0 0] /H /I /Rect [ 82.4310 699.1581 225.6975 708.8106 ] >> endobj 50 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/article_category/epidemiology-and-patient-registries/) >> endobj 51 0 obj << /Type /Annot /Subtype /Link /A 52 0 R /Border [0 0 0] /H /I /Rect [ 26.2500 687.2933 97.7857 697.2140 ] >> endobj 52 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/author/vanessarangel/) >> endobj 53 0 obj << /Type /Annot /Subtype /Link /A 54 0 R /Border [0 0 0] /H /I /Rect [ 103.2067 687.2933 167.6933 697.2140 ] >> endobj 54 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/author/annesmartin/) >> endobj 55 0 obj << /Type /Annot /Subtype /Link /A 56 0 R /Border [0 0 0] /H /I /Rect [ 173.1142 687.2933 230.5515 697.2140 ] >> endobj 56 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/author/hollylpeay/) >> endobj 57 0 obj << /Type /Annot /Subtype /Link /A 58 0 R /Border [0 0 0] /H /I /Rect [ 489.5408 437.3851 511.2248 447.3057 ] >> endobj 58 0 obj << /Type /Action /S /URI /URI (http://@references) >> endobj 59 0 obj << /Type /Annot /Subtype /Link /A 60 0 R /Border [0 0 0] /H /I /Rect [ 269.5417 301.8998 391.4460 311.8205 ] >> endobj 60 0 obj << /Type /Action /S /URI /URI (http://www.patientcrossroads.com) >> endobj 61 0 obj << /Type /Annot /Subtype /Link /A 62 0 R /Border [0 0 0] /H /I /Rect [ 438.6263 112.6051 556.2210 122.5257 ] >> endobj 62 0 obj << /Type /Action /S /URI /URI (http://www.duchenneconnect.org) >> endobj 63 0 obj << /Type /Page /Parent 3 0 R /Annots [ 67 0 R 72 0 R 76 0 R ] /Contents 64 0 R >> endobj 64 0 obj << /Length 8295 >> stream 0.271 0.267 0.267 rg q 15.000 30.256 577.500 746.744 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(update their data. Participant data is curated by the DuchenneConnect Coordinator and we request updates to participant )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(profiles every 6-12 months. Data are maintained in a HIPAA-compliant database. This article provides descriptive data collected )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(from the DuchenneConnect registry between November 2007 and June 2011. The DuchenneConnect registry data is exempt )] TJ ET BT 26.250 731.762 Td /F1 9.8 Tf [(from IRB review as existing data that is publically available in a de-identified format.)] TJ ET BT 26.250 695.159 Td /F4 12.0 Tf [(Uses of Duchenne Connect)] TJ ET BT 26.250 675.205 Td /F1 9.8 Tf [(DuchenneConnect is used to educate families about research, inform about natural history, facilitate economic modeling and )] TJ ET BT 26.250 663.300 Td /F1 9.8 Tf [(feasibility planning for industry, and serves as a recruitment tool. Increasingly, DuchenneConnect is partnering with academic )] TJ ET BT 26.250 651.396 Td /F1 9.8 Tf [(partners to collect additional data to answer specific hypotheses about the health and psychological effects of DBMD. See Table )] TJ ET BT 26.250 639.491 Td /F1 9.8 Tf [(1 for more detail about research announcements through DuchenneConnect.)] TJ ET q 450.000 0 0 225.750 26.250 403.860 cm /I4 Do Q BT 26.250 386.836 Td /F4 9.8 Tf [(Table 1. Announcements by the DuchenneConnect Registry.)] TJ ET BT 26.250 367.431 Td /F1 9.8 Tf [(In addition to the connection to front-line information about opportunities to participate in research, participants rely on the )] TJ ET BT 26.250 355.527 Td /F1 9.8 Tf [(DuchenneConnect program as a source of expert knowledge about clinical care, genetics, and research participation. )] TJ ET BT 26.250 343.622 Td /F1 9.8 Tf [(Participants have access to the Connect Coordinator \(a certified genetic counselor\), the registry team, and advisors. To date, )] TJ ET BT 26.250 331.717 Td /F1 9.8 Tf [(more than 1,000 questions have been asked of the DuchenneConnect team \(see Figure 1\).)] TJ ET 0.965 0.965 0.965 rg 26.250 141.932 555.000 179.905 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 321.836 m 581.250 321.836 l 581.250 321.086 l 26.250 321.086 l f 26.250 141.932 m 581.250 141.932 l 581.250 142.682 l 26.250 142.682 l f q 225.000 0 0 135.000 35.250 177.086 cm /I5 Do Q q 35.250 153.182 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 161.562 Td /F4 9.8 Tf [(Fig. 1: Categories of questions asked to registry staff.)] TJ ET Q BT 26.250 107.710 Td /F4 12.0 Tf [(Summary of Participants)] TJ ET Q q 15.000 30.256 577.500 746.744 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(update their data. Participant data is curated by the DuchenneConnect Coordinator and we request updates to participant )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(profiles every 6-12 months. Data are maintained in a HIPAA-compliant database. This article provides descriptive data collected )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(from the DuchenneConnect registry between November 2007 and June 2011. The DuchenneConnect registry data is exempt )] TJ ET BT 26.250 731.762 Td /F1 9.8 Tf [(from IRB review as existing data that is publically available in a de-identified format.)] TJ ET BT 26.250 695.159 Td /F4 12.0 Tf [(Uses of Duchenne Connect)] TJ ET BT 26.250 675.205 Td /F1 9.8 Tf [(DuchenneConnect is used to educate families about research, inform about natural history, facilitate economic modeling and )] TJ ET BT 26.250 663.300 Td /F1 9.8 Tf [(feasibility planning for industry, and serves as a recruitment tool. Increasingly, DuchenneConnect is partnering with academic )] TJ ET BT 26.250 651.396 Td /F1 9.8 Tf [(partners to collect additional data to answer specific hypotheses about the health and psychological effects of DBMD. See Table )] TJ ET BT 26.250 639.491 Td /F1 9.8 Tf [(1 for more detail about research announcements through DuchenneConnect.)] TJ ET q 450.000 0 0 225.750 26.250 403.860 cm /I7 Do Q BT 26.250 386.836 Td /F4 9.8 Tf [(Table 1. Announcements by the DuchenneConnect Registry.)] TJ ET BT 26.250 367.431 Td /F1 9.8 Tf [(In addition to the connection to front-line information about opportunities to participate in research, participants rely on the )] TJ ET BT 26.250 355.527 Td /F1 9.8 Tf [(DuchenneConnect program as a source of expert knowledge about clinical care, genetics, and research participation. )] TJ ET BT 26.250 343.622 Td /F1 9.8 Tf [(Participants have access to the Connect Coordinator \(a certified genetic counselor\), the registry team, and advisors. To date, )] TJ ET BT 26.250 331.717 Td /F1 9.8 Tf [(more than 1,000 questions have been asked of the DuchenneConnect team \(see Figure 1\).)] TJ ET 0.965 0.965 0.965 rg 26.250 141.932 555.000 179.905 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 321.836 m 581.250 321.836 l 581.250 321.086 l 26.250 321.086 l f 26.250 141.932 m 581.250 141.932 l 581.250 142.682 l 26.250 142.682 l f q 225.000 0 0 135.000 35.250 177.086 cm /I5 Do Q q 35.250 153.182 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 161.562 Td /F4 9.8 Tf [(Fig. 1: Categories of questions asked to registry staff.)] TJ ET Q BT 26.250 107.710 Td /F4 12.0 Tf [(Summary of Participants)] TJ ET Q q 15.000 30.256 577.500 746.744 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(update their data. Participant data is curated by the DuchenneConnect Coordinator and we request updates to participant )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(profiles every 6-12 months. Data are maintained in a HIPAA-compliant database. This article provides descriptive data collected )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(from the DuchenneConnect registry between November 2007 and June 2011. The DuchenneConnect registry data is exempt )] TJ ET BT 26.250 731.762 Td /F1 9.8 Tf [(from IRB review as existing data that is publically available in a de-identified format.)] TJ ET BT 26.250 695.159 Td /F4 12.0 Tf [(Uses of Duchenne Connect)] TJ ET BT 26.250 675.205 Td /F1 9.8 Tf [(DuchenneConnect is used to educate families about research, inform about natural history, facilitate economic modeling and )] TJ ET BT 26.250 663.300 Td /F1 9.8 Tf [(feasibility planning for industry, and serves as a recruitment tool. Increasingly, DuchenneConnect is partnering with academic )] TJ ET BT 26.250 651.396 Td /F1 9.8 Tf [(partners to collect additional data to answer specific hypotheses about the health and psychological effects of DBMD. See Table )] TJ ET BT 26.250 639.491 Td /F1 9.8 Tf [(1 for more detail about research announcements through DuchenneConnect.)] TJ ET q 450.000 0 0 225.750 26.250 403.860 cm /I9 Do Q BT 26.250 386.836 Td /F4 9.8 Tf [(Table 1. Announcements by the DuchenneConnect Registry.)] TJ ET BT 26.250 367.431 Td /F1 9.8 Tf [(In addition to the connection to front-line information about opportunities to participate in research, participants rely on the )] TJ ET BT 26.250 355.527 Td /F1 9.8 Tf [(DuchenneConnect program as a source of expert knowledge about clinical care, genetics, and research participation. )] TJ ET BT 26.250 343.622 Td /F1 9.8 Tf [(Participants have access to the Connect Coordinator \(a certified genetic counselor\), the registry team, and advisors. To date, )] TJ ET BT 26.250 331.717 Td /F1 9.8 Tf [(more than 1,000 questions have been asked of the DuchenneConnect team \(see Figure 1\).)] TJ ET 0.965 0.965 0.965 rg 26.250 141.932 555.000 179.905 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 321.836 m 581.250 321.836 l 581.250 321.086 l 26.250 321.086 l f 26.250 141.932 m 581.250 141.932 l 581.250 142.682 l 26.250 142.682 l f q 225.000 0 0 135.000 35.250 177.086 cm /I5 Do Q q 35.250 153.182 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 161.562 Td /F4 9.8 Tf [(Fig. 1: Categories of questions asked to registry staff.)] TJ ET Q BT 26.250 107.710 Td /F4 12.0 Tf [(Summary of Participants)] TJ ET Q q 225.000 0 0 135.000 35.250 177.086 cm /I5 Do Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(2)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Muscular Dystrophy)] TJ ET Q endstream endobj 65 0 obj << /Type /XObject /Subtype /Image /Width 600 /Height 301 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 600 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 781>> stream xA 0 =" ʝ<2;EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$Ebw endstream endobj 66 0 obj << /Type /XObject /Subtype /Image /Width 600 /Height 301 /SMask 65 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 600 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 58662>> stream xw|TU=IB "`Æk_׊+뺺VֲV,4:RB'HϤM&}2IfRPWTx;<99;gfw^x^~TM p<9ysnNNp <9yszNqS\&p<9yszNG@xs</8|ys烚38@Kys烖S8)4]<9y>9:$8^<9y>9ECGB@xs<$! {"BH,;,& +U4~'٬f@mpT˲EpZ<a%on[D*H?fV*K)j@}e[-H;. b%a,K1߱]xs_!Ctx]m-ŏ׆+zwo;gdt|]2GK-bU$[{/SR)N}/?p*F-VraJSrcr557x}~օcm='<#)=sۻdSn^L8PκuV~N掻aRlkom+8rr&d~wJN)F=A~ 9g7oz|s \\RT@;)2JW}Yx2 LUmfy%oˇ{u-|JLLgPyfse1tvQCc+F>s\Rx{%nSTWUMN`~x2 8gK:[YU)py/a~tskӁjk+ܮVon=ZrsGm.ߢP! qgWgs~=I}B8|1 gxzWv7e}$WEdfTug]ڬn@hIׅi߿?"6)qCS/%i;˷V2WgM|K ջ߫78qJ%?xTɎMوIw3@EU7n\28G#sqTjb2 ߟ:n t(ood# +N3bmE\t[LnOϞ.xJa6}%-I7-NU~~w|)+S I+zq/jCQ513nsi1e-gbr4:N[t y̷|ujg>F&DUyQ`n 68gC3nدE2U_pfW3\uikXēYmsBE 4) IwN}/iICLjDjEZȼtϚ0Uw=$3c^Sܴ*C~W6:vư9eA4*Ql *mn/jQ;Ԕi2'ɹ2]iU?!S=Wgѝ=j;(2Dk8ڋϞ?UM6 1Xr0@ eipu40i]PGZb-,jg 4x8&"c&B-$>̉FU{^Ys iDflFutTn뽽ڝ8:ʷ67z$yvBbLMq8&/2Zq$Z0$~dQx%LGoG7vp R&dž}q YpxI4!>{T* ijJ2Id:lhI' :Pd\l/;{(OeYw4zښflBM2b+0sb0V7tbӕ)Ҵa+>cKk\r9_&k K3 ^Et/*B8UոF}ҲsF~f1Y80964q#ei'87ι/uxCQ ͜:3|~zPR˸^!L-k7'G/ԊKlj7r'%9iaٰ64\ܥbf{ӑwkZxEUg] 6o{p0Vޜs =7\z:;7TCX@dC) J~%UZZY]qP{pآ 4aNDƖGWԻݐ2.6rpK1u62B(:ɽ,f'!8w=.;ٴ-jh욲:!KRto]n@JpEG"tÇ|yjsl^/]W0;b;҈]oAb&,5;xS؄u F X/l.=UguM^PE0L5JKø# `*Pj!n<s&~QWVq8wۉҽRNңwꥦg^wh{nbl:Z, n2;$,sAUQ2x6"E,p- $&N=\r MȻ 誯Fϩo/Nz#\M)M~r˂%<~AϺ鍜tuySqoYs֚=Vozo- Y\w}g?d?/'*[NS%zk 8}\PQt\ VW(?v |OQbMe-Wpv[[w 9tOy5z%[,ٜFl-{*{Uw|v6TaQk9Jn9go}XcCKϜ(gf4RwKmjvuK l^ȳ К6 v'+}%N4ֹCrb 쩿5UZܱZdnJߥ{r6K{׌bjo.?`UE Wyua7`ɇ jyܕt[ |q48w@h8l'6/Xec$F;LM\RJ72H"dxN;vn77ZbAB(P6ˍ^n% @o#*~FH_\*sv-q.P\ pa#g[K;-Ψ\:ttn2pdv8yCԿ_wJaIJLXnS6ohcG2@࠘&8x-Q^(.OaMJyWHD =RԴ9*ݎO8m4k䏏h҆K؈}fkY}kgXaiO {Uת {'%Pum;N2OS SeZ1jO}g'O1s|.`7c%nLܜQ7=V{1&j" K#O"^kOS;fZȹUx4Z@DO°;G*/;{='4g\xRjthm :j(c&>P UƏT:5WU `r4jEv7Cp`)mm--a84CKu7F3"/YG3[%#{嫏nfq3)\N TFV}H F l8n=c JY I?\ODHscz@hV tp^o`HXR-[/O6r6G{n}v0?cֿO)b冮s]Fݑr -n]V *n2s+RЛrΏ fG&D G"2Mm 6$EMQ {5b&^ĜVdvVۣ?EkEx.|92@jIM-^Ŝ^i3X@pmf#ǁ#.s3l. l&.[ $n8w=\$}a=a/idj c2]y= `E&elpyҁRhXʹ?._>|GE7x~ZZre ܿ^=-UʷwJ`mwd_"h8wԩ+Ά (?ܯ}RF,?{ظnN)^<۬!sOb|\ FC &R’yxlt<.7WoKXEǽo~8lk @KMn74E.Sco@Ы!!WH [icY@QNLWge4t츨0XkJ^4l"N}7GMQ-`u9''ngvEko<+)x{k}IwkMV_>T׶ WFB %4j}(4+N:4hQBpr4.?}<8&|TZnl6pu:u4Gzύ>7ڇ5匮{aoKZNt=.1ChVLѬ4|voqB&}aZBJ*n?;W887?Y>y׏eUOtt,c'C" ۜ q•y,8)V(YtRv8uwB $ mudGjz"Vqp59oC]9qaBTZ45guͭ&^O(2.],4ux֖| Ґ7.usszǁn/铈ȡ+YFq8 \lpZ1ifKL`DC<ڹ3ShJ=D2@842.UPQ=a/ ɐs,  DSOzB?⃲O6|b8KN71736fԨM[F3b5M =ܷ 7^Q2+ƍ1uH&1ڸy~bΞ;CEg hQdDmhW>֪Y[祵X#MQ4 'N׭34BOKq(cF,MWh=Vdhp|L9m>r+v3mQkGK"k Dlܩ7("B4i^Lv}C+KEQ9VYBXeSkR̈gO-4KDDsPe~_(s~4VwHR6%L+k;(R)/ӦF.|ܿ|<ݝuxaKnc&# ~#cgHE3(_߇s^ȇF 9?<ͽ;F Jcsi(i }轔9ys|q9 <9y>h9Eг<9yA{k2<9y>(K<97 ̑J<97p <-xs<@|y <93=,<9y>98<9ysx/[q=!s< #L'ys烙6t§-<9ysr4ڍ ys<9Bt"Xxs<B`}<9=z){<9y>9Ņ&xs< [Axs<sxs<̼K9ܔs8>9ys|s*ϐ<9y_^8<9yszNq!@xs<̜ D<9yA+B ҿ8<9?G<9= n ys烝>>AP ys <9=8;_<9y)7Er `Y6<9y>9]mV //R׽` q5<9yszNu/ys<Ĝ 9ys<8N'ZtΟ^x% p- ^xEZ!2[|O䅗E{?xstI <9B}GHu9y ,9Q<3L / yrgBZpYŇ?3cߓSSZ/jm$a]NJi<%O)3>Ru |>mbEEy~r;V;C_ ʟ0> _=R&wGNu~M $nzlR䒔TOOL#\G6qi{;* |mkR+_qGO?cxU˚̜Rؼpc1FĒkRg7WƇ]4=>nnnj?$EݟΊ}+WDn=>sTe7׭zkO̼L0݇%dq a|k\ew}M}\|O^G[cmM :Wx]f !q q~Q([{K6FDU??QW]awn߯cSKf#c\t=CUM?wJ;x`{.}߆n)zouzW^+6ʝ7yw?Zky8&g].JPV}3N*j]^\oz۟lR-\4K\ey

ӷY# ws b5Y:^߳Y<9mg*kb>xV}g!g}}5~w?H=7 v{NJ7oZ@v_dcOKiY"{7%3~=lfYkt<78=-)_>gnl6,E`їtiđW:zy{'vf[M[#^_ynWNLӳ1m|eV*q].X`o){_xrU}xY_IY1x|'-ʙТY€wgIuϬiԭ:>@e<1'oO_ɻԿ&uCr[sZ}aQKnk{]WOM9U{!Pkm?菼Jݴ#(kKv8G׿rP/-o땇?f`93NqM4 5C"mwzW&&+z˵* O-45[nxal64Qfmjx5sFGH(9š7Ƈ= /!vc[[jhdc:]^>q|f)~zJ%i:n ;6JUֶz֢ suWXxꎭ| -IZ9=Ӓ'%'vl;QR])"ֆ-ٳdkR_?ya,ɠ۟Ǚ'rm_tKˣӓ䔣Ďs{y_&ǫŰvﹻo,'? 0YܣtD.߶~hPX 7lmmgu׻wz_>)ONP ښV7r[o;M:_??JR aؿˡ?paf^/ONW?ֆ'n`ԉY ah<3lRp=OLn]p}P\L!4lٿ?]vKnl߮L7LxpʸC_{pn< ci>s$PY#N<ڦ{ BO{mٞ]Ǜ-/~յ>1&&*\6޿đ'_{)wg~`8Oߔ1I~i-`NnjId g䐄0ϟ_Cӯ>qÎh-2Ug_[&pvwW/wy5Rgٲ{ GurO]Iޣe:>mi^/g-'}?!5ןܙ\"IWc=' />vXSlwrjl5m&;f66Rι+|slG=5J@ZŃV{6QDbfZt㗟o-;|N٨}[ƫR[s2!ѷ>tq,ߞ<זoZʇ˳rEc8d-Ӳ[]ҕU~/܌xs{,@/,%S>{@wS޺b?6U/X֪_zW}>[]x^ i P~Or[4-jU58[N8ggr:~f([>I]m/Xz_͒6X\ceW%iIٿ׬Xuꭏ__8|Fswuֹ'q7]9U-ݵC5Ybʇ4@yr5RH><3pj_Q&v~恫8mpT|ƖJO;_^w~Ywq;n[Alu/~Z=ĝ~n{/6CU iꏊW>GXkGg<hɇ_lY釋_8U..__b뇩s]xkJ薂Gm/̽O6.b{ >.YVX_ϖq[` F6WtQɦ&ר^`O>];D{3<: 枵R%λޙ#-N5L⦱ a'Ol-i<޼ k>VNj7~^5#ix*O8_>] f46Z# z$$iӯbԚ;ݣ6:Zd;"]gUt> ?8q 3,.ڹ$BIrPmі8+dbobVlL9 xr2`noX|BkeEio\W*O5[ ɘewZZ=$mw8%K(:;laBe/)9 C, 6J(.e~'(7xkkoa36E+fNT갡fĴX~r_8vdz2me~!_}: O"b Z)Rk~WdEjp Z!-WɥMG}e5'k꺼|{e:vɟ=뛭/n048fE40 h}x[duљz|T&b52+B\B J:=7]ᨴ܌p/`h{T(JʝmݾfI_2:E5482L&ci)WI]fyu ӗ?Ir?*z؄qj8cn]"J~L̬]r%ıW\}l-N 'hmkx!PEimTаLd0!)F6V(zǍU&ffE>m)ڰ9"`h :~Ih<]Ml5TX~d%JW?q(pp8\'t:i4^d4!Z!)B~}kryܭ N@=㏱Ugr)TjjMD"T^JD>/}gtX P2UD&Ԛq"B,=@w]N a3Ӓϖow'FD~'x`; X PW8pDIUpތX8n8*C+/h=s˞=~e7GXL $D9.N1༊jkce=BpD7pHHB֡ J@} I;Ry . vwaڛ .;"ڳtǬl{Gr{)x3G i@uq"K&co{ z2˫Ki I64U;_j=7DH?;|aknrBRԀỳ" Df+NJZ+Šwxv4 $c~/B\%'u樹O„KVTarp@B^姶)X v d)I'- a?a^%"pv4ݴD/lƚkWkE5\ p^7V@w]_?vdHDI}#RЭ (4ʾ17=rpK޺ Q~[pV\.q ܉) 9tU 6}M3RnxuE2C U)Ű*vy"dX+UW6y3"X4y]/K&:Z+Jt V;~\!U;_n|zVs̘oWH^!v%B:@vϩ'nݔ_'i$ MmT՚}G[{ EV~Yt{\U?^AOtյc^{\?w4ۧ9L%ek2Ԟ۴|@&2\mh-+X?<-.yBpRuUڄ#'֬ްFW];3=#I:YTg+79\?q uuZ]u]ݧ)L)fV5U}7E_#zt\ƃ7Bw~o >:)Y]ScÆ}5ʓ_9Y(I5.G.<:EHGt5+xe>uƌQ5tյO[|#}xn+N\(U{g5owBR@9\[v8pJ*uwmK}9O$$ʱ4pY4 d~￤䤠c3zWYt- ۧo>$@biJQXT Pw)K/0Sʌ/},{=u[72mƜw d;Zbg%mlbnXϫo=0&SgHGW7N: gH`%!m'v9aԤyp'KIMѪkWah{tl}6cWO҅R48P+K2iAt=wNU:&eP@&S&equmi8utߐ]G.s-MR9,4oĢSiAK8gsw xtE鿟ĉ2p }P⦼ S<[5'<~}3GOq&z"Q̫G|Й.[\O N&8cæv&: fFDŕHAމ<ѩenJr"#"Šcg~ $ԱǠK Hv  "#ŠN^ͭ #)J 0M=yph ȕs\7У SXN E_"# kh_ 3e.FM/ױsd2҅4 tŭuqz=8?MXD*bt2-(f⥇GdصY(w3maox4qgFk׶-4N=O{gS&dF?L!ajS#,J +۸G=7^޿) Tg]q?87ehB'<~4sp)j7S)?ӝ6t0%8_C!Ÿw+c#FHz'>=[zZ* }_gK7CQħ|CQب)yJ|CKW r+(%SlHvޮ7X 'ॅ&Xw1e$'SXn1@׫U+Sfi5lYJ_ЩiCSPT;05r4{#η6MuY4qһbpe|zV|Gim+\ J. OFS7\M71V.2BөyM&Rl- icrjU o\l#{ss4pn NeXnu{X-Z7 bMG\/#|RsjSx˶Qc~#6ՌJ\!|*xۍ6ݿ<_}.;x@ /+xG+ R t)r'Wr1?#574ӥU;9 #5%KNs#Ss ~BnfJBnS{/ }: }"xu8qGXZaj3 8ߗuV\9(N #*N\B=enCqAHq|p#8Fh1|b=$#Rd8WL0B4e$t"8#/]UXGGRV\1jTT[Dq-l>Gʹq+S UGq ]rF2צ%#c*RA߅ƃkY@q-l>G䪆S[#8F\}xU\ʉ8o^Q8 Ql8#8<5ZN#8#+s(CqG) Ep?#㠅'jjpX8(^@?#qۊ71Pa#@2?#qŨQ@=q0q6\=B 4 qGqY #~]U*, 8ߛW ~Gw#DBBBBB-!f # 6'j\cCXGrm"Oո2*!8#/Ή'0C t/!!8?N+ S  ɴXF~GZGqGW{#8\m(YfGqq`8VTF!8#/FS * Aq/GqĿ r9^&"!!@aHH?E4?RMdP)L DWaӥRX"FVtAm D!*Z)ÀEJ(qXtvBtjAK;qGq +1-gA}8E=G/qCR#8eX, C\5J?אPvDWqq%W<#,_x1Af#!i UbxUR!.iGBB0 Tk(8:n*! G3#6Q4R\ˍ8 ^r8ax\9jlVz}Z[ /鵫_aģOwNsi;f Ii(+L {f[/_+7o'( qT~܌WGsr8vbPL vCMkim%^[:?&ڳhu˽<-ʭ 콼S6o_yny ｗ^9߭kV M͟S.>ļێ6w#I|rj ~YqsG ~~._3a,e.ceWͻUw+6SoZsɹAJ~ayaIcW +/M vm1x|x[vGC&}X5!ݛҾ~)ZnK !ɭ¢%4M TE:f]5_5ݕC,sd~<__\R\RqrTA&Ks+MZ.]P/<׮Hʫ~DF$Gf~:D+t^q*82:*:};? QY]MݑZ?2aQBtLfC/NGtPicF?yЯ~~]sboխ/e%5ߔ_!v'kw21K|xџsOq_>8 :O;k nA.ю~V_vt_nK~}3K|~gU~ bVN&) o4U"o]w/V{/Pԓ(MG{2yUҘ[']tI#CVQ) E ^_G߹ǩ'=ss]lLtq`1O?Ұ-ˤSd,[ ___TXėjk\-?%D 9^p,ݹ {~%8]I'\^i\@`6O-@-Sg.}kǜ\Bm5i["WDUG]zxg7߾?hbIgKp\O>~bd1eq ; p\KJǠ8˚ WN5,?qxT"(~vj ]Y8| -yA{uMtg/N2jK.^4Ȋ1rfaǭ I+q)T!yÉV[t%v9+̏|r೟0 `ܜ!YM7eҔ₣Su1Weq69+trn'_ MRMZ|e(p}P(\1ѱ ww'pYq*ǫC B6OEg 1qT73ضҒQ^rY^a8uH&WcO> 6%cGrpew~q`~Ͻ/Q+r~fl岄wfV{)vzq ǣߘ; P)T:E`*b3 R~ JTſ{-ۇLZ(c3YgXrR94DoS [ _vb3YLI~}'H"Ν͐޽uSS;8hjl6EC_9Gqr(:Eb dL*@lrsIJX4@&|slV r%l&`biRq^7Y8HcґbO2<IΝ_L{^U>aҩq- Й,677 :F]n] Pyo[ +Iz&4to;y \_rAd/-qxf ttݚc?U,N|<_ӛ&MV$~z"1g&*h󰵧f0 YϣcS 1FZIFN άru.(^BNe,=Ӗ6!HQԋqI9t@ is2s"ٶFcЧý/+24le6=8k#be;{rē<3tiWtkgAo?Gc c2QQn]fns{6)ݵWS'/1PᢒV,yQ`ٖ164I";pk(ԲW RRӚLd`ڢSK[")IYQW?B$8yȎ/YPP_^v-0iY!v'Fە5 O/)b Ɉi[;@.1uL*=s87FFt;$ǧgbJб:pccE5SV,c.R\rtv@='+&M$,Ώ⿬Ľk@˛77r9;ubyikNiĐYa?F4s:͹r.g9x5q2*=~]gO:@AVK5nLinԛ***dRrt)τMY^,77fVJ:Iʶw>~c6{/?aŗJM2b`fC\Bf`>aV7O&z˟C[o͹Dxr3E3iҼ缸xs"%/o]-hަrP>P S~Qk\.Q[U(GK*PmyvL=|72p\ /Qt,,ݯ|uk7ԩyLH***[\&l-ꪥoБTNwP Zܿ#[֌k@ђD,IiMu\4C ˔'YL&Ey$'~:N޹]oi1i?{T XS43ҩd*y јӻ=5k:W<'\*4n(L-o5nß]/ zohˁ^^&T=4oފwjgg4 ,oL3vi:}ՎeVzд L*.Tuq |oL/%g@o%1s-u8Ťޤyd_XО{hPF%Cc7Y4D$=;Z-o_~OǕ $72)|˖Yy18zn༽NVMziҫY}ޥn]kOwЇhLh7A P P0`D&Uѡ3e!yӷwV/ϣfC[2NS: Eu.uө$\qBյ9f֫6z`nk D<1f/JʬdUvj>r{~_6s7ԛ_4R'\8 7xYnڨa#d.W/oLPcXX7/g$͈-,s˂:ƾtթBa %[j>z,\]wɐ:^q}͍]ؽxÈ&P}pMkYcbwYr2-{綹͗·gE۶2maf(KqHWCqR-.-;lʞל`ff{4\{*druaӥfYylylNi:}[:b?{]ѕnગw!_r|ÞY@;w~=~u!Ҽ+dkϦCųf@֍5~>;vF&G+g|5\9 }С+eMY``ѿy6.M>yu .{;R@>MlܛhgϘ,t7?,$qUCޞ'N ,\ NqjN-t;b=G{F}]=W5ZIe,)fq84-KehXY}& H?9^㺍۷lVq2jթ]/oi5aϚg`zq`F&yաgVl0zВEyWa_<<]>]#{ AS-kڮ+e}{76;9n{mΘwo+R=ZrՁ{{ҔWgo2C<`mF`(m[z.G>ZR9/JO|e> 8._o1Wuzt+ jIc`!m}긯qǥn:5i0qch7S0J3]DNZOܷG^wZp{g "~Q: .>ج~hƭƭn<kĂey@C{gR(8]tSS6Pc_S<u >;D1t:iIo66vkb~ ,oذxQl϶ٰh^mЮ`7 "l!e3lϹsjQ._U]Lċ#6egl𿶁XϚ{9K.<%_xNTKq, 90vc8.#{;[5]FO wpv8= ݊V)Zffgg>9$RDŽbiW!Tؘo#19@5rtCtL S#El=KOb0-&./QgH``htk~ֻ6vj{n?IR>Jd86MӱkX5/'s\Xu[ҔC BॽtS'C3:E"10 ]<%"KOɥ6vQt "?JwmP߀ %Ku=lXUVF *&D aY6qP "b6nu^j)>[AV.lwGIvdR{(LR Tmtb3]rҜb`X8)HYTBW,cb< )7ctP A.FMeRM )IJ_B>ű"#G{KKwWAL\WC#HCu?´b(ZP4+׆H?MmNޱʥruaV.qX46#U"ss˜yu̼\tؘ"ScgsXU~u\ _JyF&JON]@PR !$:H˜beCEb:Y)V4%2pkb_8 B\'3/l?טr~1gzFv>$~hFEqGK9,?W+}IqGqmh@8k?>h !!}iHMxHFWHHHHH5CBBBvd*$},ưb"NZ^>W9}"/iX橽vEIIן  zpc. вAw[:ߐ?ڴcD_\˳1^V?fTO-Xy<ccWo\CWK|'^~S"vU_/ߒݶoY`k̨N|ҁݥincr#xl *š^#kʵ*OYaMAyj?߆?7r9d#6'jzsmyMZĵ!/Nnzx LckRkRq x9X64񰡁a[P5M,'f<'1ql N5m$ڤ%%YB ;d<ЧǟwM#)V~䛧KO|?WF+oۨiqGi=$O>ȱwMq. h4=ϡ= 'r3/uK5p٢nN콕Q@}iҋ{ پ!`o{Dr1х1t}`Se}| ^ҿ˶;u/kE=UIv.: ܻn[fS4e~4A'DŽS@fإÐWHQM8/@p<#'bV]o@"x~~enM/*`߶{cj_rvI b,16vPܔУ;_}&?wfvmka νwb׾ U_,p(9u ~īëB=~+K[8\~̃{w姆 KrZn}qނC"KbDP$Hr S"߾xo_͈yE@9ODgup4BO %޺'[ O *Z," D91;Zp_ +ys PKNf(;"L0~lH(qY?Q"D(Hq\. DBD] DBA'F<& @Vl[sPtsݝ_d闔U_޲iP faBK3c5BH$RO:ycP =y.2jo1Cյ}W&w7ma;71 f}\:vY=|/l^pn8snl ͵C[9[|SNdz6}}9;Vw5֮^OU[vmƄ 0p;zw}zy 'tNW#nʫ&nI`71sGNxN+6R@rdʐW&v2hosbg#A"Mܱ~rq{׼%YOpa]3G#>o5iI;?u;90@h߰ygogY-8>OvoEEhfZ'EC0a8 ˺ʣFmϼz%n-?/3_ƜF#RZyA/d+1oٿqA>m}Tfu}fRy']K}CL_S#\ d[5ρy1ؕ%$60p=Z1ȥM[;EH K$}b,71*>)6Škpq^zTbwL:wݼ)]2*ʹZ~V+qr/)Gϲi֙tl712nzåX 8qeF8RX\Bqvdٻ b)^c`0+=NR>q=bz:97zaG%7%_)禍n ѹ?= ~58 Sі0*ғ>},/N{/d-^.Xױo h]g QlE%z:z7sbT}@&~2WFZSdc(L(J$ScU3Gr%W+42ejK9qD \..>woW*Pu}'EYmJLݹqbc;#呖mR1?89c{kz;e q 3T&æ(5tq58k3ԓ']FO1rLF7vt3W~ٽ>XxQ\mdR 9* b:15}e cv)0#xYYWڴqE|Nz,zxt [x%,0-o妧 U~KV]C^ށ F=թܼ(2>kK)/?}PAJYIT;wSes" )nȝf-۵Bخ%ctlh3uVuJ)O_qҵG5'k%>|(p( ;I'Mӆv0ba@6UY;gQn'=#ARVzP 2?hR8Ur-ػ\82cn)KXҎ}ZMp0`( /LY>V,c+۸/֥Put 9ۙXYHl~f'֯>,$ o@_٥[ kǖ$ذv64S3l9y+d[mO2~۪z5,p%6Iwhg W0eխcmQb߱j.Vt 7%!:1|gҊHn`bMyy]_CC+gK/o բ.p_/钥/.Rغ.ԡ sh,&B-_I q5r.$|6Ӓ|9\aE1MG8V.͌r)&u]}|ݏh:׏4+a˗{CK;҃s׬^hlo6$Zw.;Oxdagn}_5yù6'Jl˭J'L+98|W= {(yvkޝΙ[ Cv~7lz'zИQI[ L|' }">`ܣ˄Ntֱgs &V3v~t\N4woi4nyoa5Bh1f>m 7>kAᚥKk Ffd댾mplܮACGGGp⭛tgv֙4!`P^j@G{#xU\?bW/N4kϖ͛z~8qV ,62L~m^eEbنu[Y{Fq4Œy5uhc,x6Y64 \$`ݶWHXԐ#~īH,-V= /ӻ,`X8z8ٚ@T$q5(pY~jtT\&_ȮbYHzćLQy1S@B1"Ƨ @V˕W=7nk8ݒ!m4Pӛ )x1D Y4 >%IQ{B ȱ3+;"ةa##\#3/pCC 9efj/ /nΦ55äQ)łmDr")_ :DiP,ܜmTT"HIxqџRsخMX*j(%S\XfɑaTkE}au9|6nCH6}~qwdslB:B //iJzh1&le޸ G5޻Mat،4]m(Z!~+שSݟ K6Xn]nC ,#vMCv[G#*GH47)abin\nv5ӑ  td:/'UrSCP$U#gfId:IB<qM]$:DbI!WD'1'UrSCP$ $ՌGâʮџpgpш$WpL Y~U]x\ѱ9qsL Y~G ^5(8pD Mdx06}"^+L H6jpmdx\[U%Oī֑'⥼zaB"D8qS1up3C_C]DAgZ.2?Vի%olZ`?ϣ$r:ÚLd9zK/,?7C1у'l)8G!2']CO zyF爾`Ek]{P E=N-&C/:\GqRqCt9OwVHGMKI3&zL(/3m;O?>q8;) KTw/}1q #,GdR^׾!;~|hl8iݰVtz9M;јtv둳/pIA'mv4r$];%٭lM@~Oda|k[)գ6v<4sl2nd/\ݜ\8WL;Lݔ|x_楾]4ogefdefĿ0OCRIQ^V_"3J$Pzۈ4 ??3D*ggdJЇ7+<###+3ꡇ?]$8#+3#+=#Ź9\--,ʁ鍧,H K{}rZVfFVM;L/O EwvY/LOyynySye'#[ ^˹q]8`8"4~8^in8ZN>>ڻn8Xaެiepbom>ۑm7/ AcfzLh`ТYχnԲ Z.n43G$m'nX= ˏܼlˇ_uEWo2tQ6]3ZN L-}6:dʁNdpcR쿘- ~eݼﰎ xv#z;zW"yn؉NC߁c}-10v۫Waݺv֭Ǫc d|~UF<~">>001j'#;)#G1ƺ  Bg{|9ʫrT) ^N2e80k&CǏH=;IE"6M|R,$)hIH\SbnbsssssVdn chbYژRr)@NhtzٷIR^plK?Wɉ)ԦR.8x-@2?׌Nej©w⁷ϨJ22b"XCE})MS#e 蚙EE~񯟥Lo>qc'^9%@*$SG)dUǛ1(a}|['AyUʉQAJN!nSQc$x8`.5Pڮ`0L/]U/;O5šٛO=91wR ZG gn*(,!1 EKW`y-n>q>26..Q=NG1 Mge$~xyuC <T%/8MttLJfX4~NAĦEDž9u-JkE>@9*R$xxrArA8T#83ZNAx.|}|}Fyu)Zic퇹jپc2 e~KSz/]|ض}|;}W|NMh{ZSq4~.=7vi;~T^izC.ahlO;t5o>U=ܽ%K{9x5x/#"Uz%m_/+qj :aa9n4sfHR>4F]>zjIߊħUsFqأwr+7Ow+ ">&=0@)Zذ/ھ -<,4_cOk/LԱiWO5va/) {iZ džGgJ Y?Zc$~ /#\P,-,`@t`a8(#NfäSAԐ-x1I ^cau9|>I ^N)cpΉs0RA īĀgP;b0Iϱ/GqĿ;qx8y5@2?WsUr 14B89q$k1"I ^cI ^Nr q=$׬sҦ ~9GX 9 (:5) qrsdx :4~1'8I ^NWPby'7WT9A0"I ^SHp#Jqp '5Lj'i ^cJ5k#P-  0EQb8qE@yGO?טIsq'īiP+ˎ,~:N Af\nUs8(bzC\$~ 588N?WS8`RY8ٹk4~1G qd~SE)eEUgPA\AIrE$ī)/8`#N~Nx9`@*?ה8 ^0e4Uqr}J+=BDJnj#Ij#$Oī]M.(!ī)c*ŭ=w89@*?הxM9>$~Z[p@t 9 ^38Ur ajB'?/-`rAfS ĿcF*?Wb(RPI%JqrŽTk'~1'J?W0PUSNj5ĂZQ'Uq 0 Sxu8 m pUⵂ+(HqpA$~Q(HPT*F`6gAZaFQPQ(aMryCZ%# / T0 0 QY&x%⸔Lp/q2r }69)$~1t2-(fHs3#+3lA:J<P>tB\!,~:N%y ^rqT!?UsGb/qRsBĿKx0pŨQ Sje@t\L?RA(G/2A:B,8Nbqs kK'9 ^cʱ6r;B1Lُ %$ 8I ^s,JAk9N2?WK8F889!AΉ58:&N# 0 #]?{d/ {% j]ZG:=V,VNܸs$T>9<;rs/@.n LOl.Y! kzp&w@?LwP`]9@ C;6_O4d zph3.謻!b zx9.yaL?D&B@ez[o7U6T 3K3c:rEFaz[.neߍ'7ث&Fbٖ4JT֖L?QcY_ŠB/vOǧTZLsdM<.Dz >E8TiBT[WQ,,8T҂A!j QCCbiKܽ"Y+yGiF6{RXSYr̍_Wjj$ č5 0fh_)*VhlShZR_]$-̈8C'4_`=WէyOv+_M1u\R[X2m^[W?p{{(5aդQ>rzQ#G}ө'h>?ndʔj =3]Į?pac-q - vM8}5*ER-7\>ggK-^gާsמrmGr)^P|{/cj[K0{籕7ۿQ3\}^ޔsΘc6J(u\!y٣&L~Xo/ʸ|t皾1- ⿥]kh0{Ӕ1WQ-qc͓ 5NGx+En~>a7 {=}o'm;ÿv+?`{ۭxo& H{R ̽p"m/|gtр6SJ|藕>D;|.޳m[?mJg/aw9ocyK>,|7 9׎[ ^8йcXsу[bJ '.tQ{04/guu~dMXݹw#+G LP B󼚱G\F,dF5KIf?{S<]X2'3\cs𾣔6՟02!ݱ7Nv@Ɣ˖'%.r^ݹċfx.Yl`~QL}sy2gsE1^>Ԃf BH&,%Lر~I_fՆL`guIXi]>t2 :v/Fi()yvf+*9?,g5ӣhĿ&{ G a[Eh_ܸ[*?| (*a՝;wU"KK%}fL{}fC-D$߻tfk/yr0}qw/gEKsDB&aG[yR"%=Iq=b:kQ2 <:bd\-_۲} RhyK}lg7n?Gݚ Zq<:q 7Ε5W-xr68 Վ]ݶtˑj._^28 N1 2)C%ۡƓB}y3k R|zρÍN%%J:N/d*M^S.^aEĹ> eU^p*)X8O82 !_IH8u}LEk7DyWر~ȴ NڮdUk /]=s4v~yz"4j ?}]uo/?R8}TҒ1'v'i&=Zp*)ᷕ&7ݕUcC= ޳O9<5BXSʍ;MfCɿ]WO8pG;5J%u N%m?*/nr4"'ܶ^(nٺvzl6st&nKsSi^vYeR(K-|[:8֓B'PM7Ϝ?GGRܮu*Հ?cQe~櫈bQ7վWA?ᣙQ'0zJ\]_UnL#_2~Ԁq#|Ŭ5"JQHr̷{|Rž a̲dԨJ^q}žSI ;{ ff:auOq󡤄SIC\͓o*gGvkdY\©_Wd7am©ˇ%G?9֍V.xt.x@ :Hг+反4cKPgo|=$ sWm&NJ6s.%93i{.=m0$U7R Ф[] Y=P~ ν~iB~f?yw/׾}Q!@b|ug(bܚj[tҾV9C?rbց \b=EO.;; VOgmD7ߕOj싞$ȣw%ڔ};NXY20ЄzF{?zjnSf\< qrvW/[+]>e(*!Ѹ%f!\~w㋻OJ5ʨZ&Z:سdڈ@P:Σ@b;{8DJ!B>xۿ0s5~ LV_z\1Oggr܏ϯw`bDxlczsLsw7mWw`ݶW ktpbiQfaC S` H _mMDRӺVy1'^6ߦN2J"Q4_\HFdZ;KxERR>q W;:wG{4\( s-씸qm-+@|ɿ⮧VVX6d 0ζ C+zX>_^#3Wo11 'gtѫ b|Ës̷ەGs'x`⚇rfWN!~ڹ|7#GSMh{Mss^=|{,{r|Zq;Q2@ɵ=Si,fc*ˌמ+yTO7vt4J X5dD?/J*~xU <.)SfjXh/jNyl>B@ڃZZPpC%)չׯʊ@ 5ԕܮQF$CdsO55PIWOs@7"rN| *D] Dgn_alCڇ]@h6!SOl7G^P*j~+6~~RJEj"D$ۄ-xr>v63jb @ o3Ip$#c㖲{69so,_pe4i^ŦO0uՓQw#tr =}TG66fPdf\?M"Z{<"m7J ~LqA@+_o;GUvb Xܭg{ZJݹ.L_o+B|H#>(},Mc WmCxZ*B0oǗ[J)-}\~WqjaPqI;q#WE3dN&i4rU"^ѓaR*R$I!noMш=8  RJz&zC_4S/K?sx{w`Apy|GVan*H/xűx~eAe"(D"Q8jWWѨty#IPaa)W$Ssk6 _ҏVAn^מ$@pTh{`4ToI+S/&cHwȣ>k+`“={gC%4O&u~^-8Yys[ARQX|w3"{8.o;/Ts=n~i& 6;q~q΂rqʢҠp; ';WfҮyՉ|w#[dP4=o4nW va>n kO1Tzwal¡Vmzf  ʭ5+2-^#_Wz=t[w#/N5雾Tp̖AIKytw|k_ s"0 h=[ަ{~cr^[Bv}eosLWV͈X1w/req7եEߦǾKf|}plmÆ;G~;c$1O I _7e|RS؄_<'%,iݜp/cjY?T?tfdM9y.Z GC-2p&]%Z9ى4;]1 w}׏Չ,ט飼-)s%|4W?9~%|[FR^$$2[+#J|MǂAF[yǙ!Q̞:ƔH/g{B! -Nɕ"hDLAb+\725hn;{~S`t4QA}I#Oݸ~eSiLr7ܳo!ݪWtO9'E.6t&TmX0Iui=RS!1`RI59 L:hќg%\Dd _ph"3d"ē^RULG1ebAy=l!MeRwD3 !c%!d0 \&j@ouI~P͔,$F=|@%,/ey{ZR󫊛).=ƒ6= ;K,0!DK-R$Ǥ {(C(_u%lM*S Ŋ7ٿVwߞNĒ \29Vl? _ZQTE3Ts׏#LRW ~Ȁ^k= '6e5ݻ a$[KؼG7c*?_?;q >)|AVZ{׆Bjam c1a~8nؽϜf y:d qEoW7WfqDc)!L0iD={EuN.+*ӁGғV̴@ r4!)n,kI"Nݾ~c2]n9cj=m/z u2<﷉JY^S/W.iP"d &Ly<m8&Օg,Iaa9'o)AJ*5 0%T 05;of;җ+Kcxٰ tKʘJ&5.inKkw[lFF^ig >TCcH7 ׸$=;7T2*d(7K"2(;[堙Q Fod]Kżu_$<~Ȇ `l0Uw:`8zx& 6N4/ViI00=ĵa0N &çoir1(/\3, GO_n AO9Ȁ-+x}`h#^-xpdٸ~5F\y A;moCvҏ>q #iWl{{qګZR$H;S˸\3t;休T(oG-(~&SY=*yK'U)WgVM:^X)O?ƁWyrObnʕT^ޛI߅knAڽ?mM\"(ORIbE?gHl\pI%}}+>vCqiq?Q1a{%$)~h>2.^siN0kJխ5tF{ac#wkR˩V)I{óJCRRuLjKxqrP.c}ݤH*@]ûW5;mfNml:sOR9i?7H]\ko f"0kn@+Key7X[KIK^ q-YgKS*NG=h }ܪ iRJPV74;{'#2NS\TYR"Pl)Ԋƪ._ tKog[")xyb[G7 NSP_!8ّfx&]0YTsw';* %&.6dP/K#ZTRZNa%u@1qtq4#6Б}sevΚL`j"O0MJZRU\(pKFT< s|ş -5 B̬mtظ2if ~Ҏt@PWP\gZY2je*iI3 yۛKx3&jzx0KKMm̵SJk5bi⠖+K9ccxKhoƣ{[viR1舾[W*G*Jj+m}$WBUaf:C!ʿנ!LuԆiْ GVW(<ՕDX]ܼGyQ ?6Xl`%Q>L\P\.+ ⺬[5EIqp27"j+xyمR@xS[{sjk?1lM%urYv ok* _uw@0m[/bKs?/7ۻ׈oLyޚtzjnib?H 0^|K37ރBaXu_TtcWωu)ם˔`:U090>aWNHYGu__x6ّm@~}t((}eΓ6-" И?Ł'$"h~qa傭1OP%X%>ǯ۶6ĒsMAoϺvu- Am3f>޸㛠G~5y vlϬi u>3vmA^0$ZaKP}sG+ Yd* 0B>YjDk:!V]d@X f\xT8GV4%I+`wC7V ['cʎ:) xJen1A%|P˛nϺسϠ!)/i5>?%Όyyo+ve'jxc/>_ݯ0Y]#dfG?4S7 B;o&gK6d3=ɇe+h@!L-UI" ð+?5LwOuɽs5E\>6څrVm'> PM{eMewY^Kf?ťSE6wqYDݺX , :_ d`gmC-bA.\w9"@m=q`𪄸ĸL*lwÆ?)=~4EHbZ‰!2ʯ;?/1.>1m=/^.e|c3F[,'-2.kzyQr7;ZM9oͭ<>m@:+-]BX3yAc~~9 %>1.Բ78C%ɵ@M4 ܬbsr^wO-'1.>qzuIT?>6vl8ȶqjW.$=i/BAm_7ju\|b\|DvΎ=j$N+E@]N8-;_@]vOaR|wm nj)5€ J?yʭ)yk*gĸɽZm~&!'q,Oyr!Oew'gO*T(ɉ}?|^:ߖG14̺ ݺ$S1.>Om:yY7VI.>1.!i~:l՚m#-#'.{$qlZ%E8{v}5/Onj< .uYO?>7@ KE>૟!Eژ]#0M{_\ٴOR@P~LZE;l`[A[6'>1.>q_ޒpU$޽W~c,݉{P~ _uwbmHZJR<ω]1}F\p Zr݄Dd;zYRq~42hL ˢׯ'zK ܦf"EV*퉙gO?-8"v_Ɣ~lK -Fm`k2s*UDC\S, ϓA;(s.-L6*٭8+QT$'?h@ʼ%M ^󧷍HP%jKglotlo磾|.Yw&98ٺݷQ O>S"sbHIq^i%ƴrs@@Q(|QT))xr48)G"rQ/bo~hԥ|G$UJ OAq zʊp:1њ8u u0.0x> "[X?s[a2qMdRyX/>&Ń&@ǯ"An*MM^nc3rvʸ!C[*"MT z`a,P𲞲E1..#,,JsȩƱO^:󳑁~Vgr}|Ly FMx/TYWT+V+Dt;jDH& _uwjLk44\o5RۛꌀAa4r+:{=?`st<wSsɦj|3{u;h\ٍͥ%^u@&@"hQ%o:U@paqŴ<9>k?}ʄ݁ CFu=d<(d|ήEc$bDԒ頃~f>'NZwߊ4v@ڍĂfYyFۜ1$b/3Vyĭ6 .K?Wƛs0l/AdZX[Q*<|xMaqj5ncFըSc?y{qw9EsFDp8RJJB~Jm>ho`9tfFU\:.Ơ'wS@]ug4 +~jDR0l}F[е@g8^Q]~0ڄ*zA?#MS*q,^6na2՘MA`⧸#077JۭH|iYO=2v6m{ز/6Mݍ{K>׎8]^^o74uiipEdE] dYsf|jAQ<لe/Б.~=w'Ksiom?vp<g6~۷9' Tј+a!Y5>|'2۟ɾO Op]>hdj 89)Sf$czp DJ^7[e}5o;w6m1r0yƵ1 0 >Y[bԂ䉂F9a*Qà |WEp]g󣷢[/qs0S_ >(2g?e1fYV{[;tg9Fu5nDY]T{wG0ޖcϱc6礷0E`pX˭{Ҟ0]LY,}_|- ä)KZ𶜀OV`",r>~cG-᫹VS#1}-jJS {9*'_& 9utzrFw/#[pO;G b@K] \^W7bJ;18aMD6.M+J G$^-WO P D^raܒITLg_ڂ'Or1 Yk%¶F6{tiGm~<-J^:ߞG1nѫ򎝻Yh702mUϟv5^PQ(a$'<:3bf8rX‚4@JJy*e=տ%niI+UX8rm9L#2,9=V,څ͚_*df :wc nICrRg¢spܼLH~hE`4־mc0W޵|r JyQ4MtVr <-%[Ҝ5^߽:%҄2aU6e-[+)=t VO#ۮ4#JސLqS+kPB'2[:ђ.- *ZOL_[=(xJ9ŁwtOt1anDewc`@vGgFЛ$lǺTKں2՚\֐}lG <{Ǭ~dT 3 D+gs=k2OYuz:_f5O8Ԓg o(gϲ`K#$8r`bDڒڳhm]/?@3۾1nnػxV1`j\_ח.;[nU7_xI3OҷCTnCc[>Jd +&$ RR^Pn٭^G*WZLiǁ(&4ڝ& On9=8POB@2\&U&OLq7c5h]RZP 2o6ljCff#Gx#@«,+Qv0!2{ߑ֨EQ\&.9C4ciM}GCLH *g/!cmzJ)E.}GD^|:?ϙFd"m՞le;1L!@HTVUXDvŭȭe2<Άu~x gbmV&"66"A"2bb{G2)W7e2[xf_>v"{ȔL_SʅM2h:q垑!8isjn\fط)ˣWoRL5a u\uPt/6Qٮ{5rrNk~d5{Z 29e𬙟tKyghRR(^RYw u`diI*":}h],ww_(-h,Qw/H7dngeL%Kw{Қl(-@tw#Ĵhf !;[+GG Pt6]p9hj(zxgy[* CO4]twj1Adr7L]Fj ^* AO_o AO}6-t=xB4``X7tڷD'vH) IK9rZoHEv\]~cϱOD%&) r0 F, +0 #zDf Bөxz Q3_ak_% ʠ(8D*^~.qb@} Hg0iW1T(ȁabBĽ;׫Vy|50v᭫ DO+\mC]eҡ4[!2f1{2A*Ee' /ү_d֋7擯<ɓ(^_Pqh<}9mލo0a]=3 |gJ= ^E{ X ɗU TcL18ܮcb47qer+3'˔Y ngt WMxw3e4mm5,nYeI'R ӯpe7^q hܒY\`lO!i|dgnQMF0v kkg:N~\)f8 w-w-˚'``Ҽu {8&m `V6חURU=JnyAXxlƢRCLWFBjzRVn//) :ecQүeL!jeJXK/jjϜVC8ݜ{1  FVXRi[S)uq'2_X\bVȸzP­qs! 9 !^KO^TҮ:s_'mZ:-k?h 7f؁t**7jo2v_2bƔw46㉝_Ξp^]׿sΥol~ܶbUTB7qѯk9 JyD_ 9%6(8N%JZFXZoI~!zԏ\ӫsAcQ]xцkt6A\y]zCdB=CŠyGbs+ WسKR Z#*|cnm2Eع}ܡ-ܬw~=oL1/@⠩NzϞgys2-6ƿ;vxrZ) O$=hro8<h3<%  Sj8w3¼8)[C+*=7 7BH'?_Yav{Woo[xVfnem\ڗKtNUnZTo²6UY;.ݸꫮz~\Jꑿs]qłFo*s̚ ^$pv~Cꐬt"_sϙPsiaAz3O29eI1`-/D<~mz~7ܷ7~cΐԆտT}J?8qP~Sㅬ=6>VI~LH_ ;MH}bޏݱ(U;孽<>>mۿNԬD5JՅ?Ί6*v.>1qxT4=0r~in#MkÓx{-\!G|_ioe-|[ L'BxvybqC#l/9-}9Syιե=k6]]r [Rc/ 8%8_өͫdžNB=WRZH=Q*@qJ ܅׬Kϳr{_{5, ӣvP]|tIտsLd gTNqBY.'&U^p͙GPm |Uɝ6_46g9c VZ2~gL] 'mXʴ)f:%vL\Go?`k~/ |z¼q&SꦅxZx|#BU9`.7H{c>|mقSSN(7O=jk!ATsUl޺nŚ]|;FTqaq.FȷhB*ΒKaS<%gYYjaܛg|!8Թ:Oh-lJyяDa)3+LG z->y3Ǐ q/N?zϮK2N^u ?x|]W#zeK*ҳrL}9oYޭC!Jtp{NTL[NP{5/xqQC7;|SEPTR!;_m䍷}=erݽOHx!:˹<՜-Zmu͔6[˝D"zo {1p- !D0.uoj_kPTHi06JyJiZ Rwp&+}-C @^P 6D~<20֗ʈ0O}n/ ;?&MIw+~dԡSsʷExRyԧڅ*Pk);z`wQqm7 %yr5vZA(UV]mG0-`=^g JRj0/.!R8nuwjP}z(>TᮄPg&?ufJLͩ,EN2 B~d\9d5M蘬iKd +Z%3/OzΘ KvzCF Q2 B'">6X)#eJC@]6^OH9|yTF4@]asvZKk[aQ?kxu-{4sVWL5qpZU% iT[)/?t@eCAO~&`uOVڽgڨ|b=^儣kI-_g$n~eND&zb̡ 9ۃBRO/suEFV.縸^eDF2h;`Z6,*ҮTp'vϴi: {o#EzIsJ080[/P,S&O%# zJq6ң}ô__'9a̐eHȞlɩ+& )I]E?8^ҿz$bmakR"p[8w2aq[pBoHDr7B*L7'ƥHJnJ)amgxSnlfG)a{6PwF(=n.3 endstream endobj 67 0 obj << /Type /Annot /Subtype /Link /A 68 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 177.0863 260.2500 312.0863 ] >> endobj 68 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig1.jpg) >> endobj 69 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 180 /ColorSpace /DeviceRGB /Filter /DCTDecode /BitsPerComponent 8 /Length 9279>> stream JFIF;CREATOR: gd-jpeg v1.0 (using IJG JPEG v62), quality = 90 C     C   ," }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?R4M'jZ ;ڎvh{A_xW [vz隿gT$5H$)c/"h)V'?Eh7dе3K<OkQ[1+i2$#cJQ_:Q^s&g/.Gǧܦ)XnQ5~~o~%|G˩iSA1.`2D$ 3>=h= |G+SҼIbsrZ\pB>;rkM7)[\Ѵ_H-OG[0\,d29q{'s^uU݄׺43IjRYG- Fp0p}+̛}hƑoKM]{MmVA=y*Ic|'s׼m0O7ڤ'#Dm9mm>z.g I~^IVYGcQ9bw]sJ^^ _mјQ^,CqҪxq\躅֧'=SS&J{y u:؋n^7 =^-wWxE:^Mr_ /t{4͒LA.>QԐ$^SԺ> %O5/SLo.PA^J;ׄxVW&krsǥǐ`;0 x3Qh}%Ưw6kwu [u˳– Pf/GD_tglAXҦRCy|8#tKoͯaX&ng[9& $CK2 ?|Hsy@u'sY 4"Դ -M2s (ey8A<~1+ I>l7Ѹ.~p#x'}Oĭ#2cm{}3mo * ]F3Cֶ/i^&RMM:ݪum$F`GZA ( Cږ=P(4M'jZ ;ڎvhψO]_/t;xWtf5K]BG&;VcWO,l$VGi3|:mNnE|jޔPö?koi_[Ixw^ Ф;,&H%lS~^E'aE^Ӽ՟t5 .f,c1Xy)?1 ZC@i⿃OPe}{_xwKuϖ+Pq88N+<5'|Ju]|4O^S@@u\4wUZ2Ic/ZN<3oٛDU F}=BJ3 E|S EmxG>RMc0N-MDT  |'CNl4/s⦟zFm,sm(V{IPb0pSSXz*мQ5(kXHem}8?l ZWMY778<=mCz׻[z)c)^w%'kӾN{&0 a6M}h| xE߂51?)崶jג$I3dhӾRI ھtYM7za UWm"$VhM|xeܴzM-yV 9g[iʑq^b@>gU#$ PC E|uWlkmRQbe̥ Y6^[*OFܢ4rͭ4TѼ5ӯ⵴6 xG١0.vT¸ێ(|XR 2F+Ĭ|=)tK)5m>ye^[WN* ;񕍺 K'K K gEdMAV`Leo2Tۨ~5]677H!,$<|6F8\+s}@!KH{PA(NԦ-Gz;PIv4tPzCWc͏],V`~i7נ+קUvHڍ%y3oti{^%|N!UO5gimsIo-H0Ӹ_ßzxQEέݵ,I,j2vҼM5$ݨ,2[V$mler=x's^>{_~$#.{九ZY\7Ԛ.⦓.esx$$70G'Fzm#VZ76 {ƭ"ݵ\dϧ+jЭN򨟩ҝM?Z/+ɇJȵy_W?-?'^ —?V_<]@-! ]ۿ+q桹}`}_Y" :U~ :ޯ[Ҽ] ~1$ǶI2_N2̊񲺰ʕ9zٿԾ\h^"]ClB!9ilN=SQ"~ߙڌ]\M_~vjޝmcqݝk,3DۑԌ]Ϛ N斓@9xc k6,GYżg-y ׷%?(?v./eܷpx]>jA;SѤU 84QERԴ)(@Ji;P(Pގw-'c@ : ;A@ J)((l᫭VD &%uWQu;d;(WwB|L7GIsL\>5wbq}^qqv; 7"Ԧq # Z[o iwY;E%9xb9ʨ'Ӛ꫚=dh9;\9;1Оs>[(5)8#+ExϊDGqo b%]U q+ uv۬6$\k|,Aٷܹhc)rwp{vD\UsuosZMͿ_aQ7 oȷy_W>5n&χ?,?' —?V/OPO:B@=Xda~OO޺ }WSo(?P>h<Ar:., &kp C :_ŖK|kK"9l ^ r~mĹj%-'s^bZ 4vEPH{RPz )@ @ڔ[i2$2ǰ5g Z5O+Ԝ\$jg` ܰl0V#/~7r] 8!YnKLo? `MlcsG<9e}^*#HʦQȪ]_pԝxFEЇ@ehZK#Wۏ Q`kF 5x~3խ[XKOl5ı҅sܞXh|~r[m6,2#<ݶO%c*ʍ +ԏVgXvpc}%Gp.`|[*)`7`kB<kY %C9,.{3V~^ [xZzi6{)nqqS:WFwg>*&i^y^YřIjힹqj5zQ_aa& Q;|Y/.%?Ͽlk{*6? г.-pю6Q5>m['n&mK7?MNUV!r( y RU>3ƿ-^}BI>5j }_?ʿgjdx~wo^Xlj2f I+K!Fb1=s,:4IfB2A>8<Qܦ-[?X1T{Y+tH/1HqD4.YUVVx 8{ X0ʐ$; NOۀ?,c>"4KV!@^ƨxP#m"Mo9rAr  A;/{T6v&QWU%&2 yϮ=k؇ǯ_I&=ve'5Ax/t+b2+ d}Et _1c} } TSR2ZXZ̴O@XԂSOZ ;Ph(=ijSP(=IڔvQ@p~-i 58Hy+'.3t$w]^]Y!K"IA*oR8*??mQ;.& K<4eUGc\i;]tgU[ɒE ņ>UT0!Bk;V&ZjQܩw  h4+XiUZkmC E` wߝxFv_UW߷8w8%"=Hk&S\M6ݴ^d(YRx3OP\UY<_nqD/s#y&cSj/oQ\̞0gj?UeU*3꩟9S|Qs-j؄9:nOzך˯_\UZ[fLqx\6:SR9vA1<=__ԡմ!$2 6;G~3Ҽ-qo,!\z}okkJGH?&4pxeG$ *~{6$~:Rr^y { VWOC#cMIiq_ħ%?<^M>Yg+ tZ,^PEc'$czM2Lp`?1Y,nL>$8E+.#ʪo;z(UJw\s]\ Xս V| `#@WDJz)#֧`k/r_ k >񩭮<-bg6{X9@?i5c)ɴ)A ;PhA(=OA@ 'jSIڀEvii;^Q: J> }}&C?} X2ŷ+hwcP:R2=sVF}QviGuY' &wmQ˼{yWb=Ȭ-gO:qj$Gq_n{o# 98ȩ+WWOxLjrD|b2yS  AwF mOl|2LS%JѩMlx3ߕh[ڸ?Qsoݞ\?e/G&{Ѽ{(l˓k3&Qy0/|"  1ȯ؟~%擩%݅M є}OP:%ç׸u*q3zSg&k(dEhK<29< |:Qnי}a26 nS(b8^8 p܎8赝BM9-J~_IbHXG32뷒2Qӻcf Z:93VA.VW2he*O,8$Mv I jܫ+VOǯ~Öml!AK`rADҕVoE^lqieojN(WLNS4²ҼaT6\K{Y{ֵ*R3΅#seH0 *2p9>݁gKnuJ&E8׫18 Xi@1Sρyi1Y.:@x}8kG}Kxx{zޗ˫ N斓7zhA ( Cږ=P(4M'jZ ;ڎvh{AGs@()E%({~Ѿ#jC׭q<20Ub+=h= 4w[Y~_߆ɷQnn1г{A-=:yۋh)Ybu**w_0k  ,K 3׽V՗n?>ⴈE i cF@u<#bgSW_w7G%y#] Ee8&Bb)"e d#3T)uMuoAגMv ( EhռG/Wԁzσekh֧,z`']t0Ԡj.[7casCki730XK3@}C[yòARx,d>ٛ^a=* ci>{ GJ j:1K4?ƾ);ZNzhA ( Cږ=P(4M'jZ ;ڎvh{AGs@()E%(4ZN֓5hZv_X[^4vҒGm,_'U?^ZlLm#~8R*%*E@#EDQ)+q4Rw4)AڃGj QE-!@ z Pi;QE/J:QEP(ցҊ(QEhZCފ(MP/z((PGE?:OZ(=h;PzQ@(=(( endstream endobj 70 0 obj << /Type /XObject /Subtype /Image /Width 600 /Height 301 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 600 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 781>> stream xA 0 =" ʝ<2;EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$Ebw endstream endobj 71 0 obj << /Type /XObject /Subtype /Image /Width 600 /Height 301 /SMask 70 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 600 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 58662>> stream xw|TU=IB "`Æk_׊+뺺VֲV,4:RB'HϤM&}2IfRPWTx;<99;gfw^x^~TM p<9ysnNNp <9yszNqS\&p<9yszNG@xs</8|ys烚38@Kys烖S8)4]<9y>9:$8^<9y>9ECGB@xs<$! {"BH,;,& +U4~'٬f@mpT˲EpZ<a%on[D*H?fV*K)j@}e[-H;. b%a,K1߱]xs_!Ctx]m-ŏ׆+zwo;gdt|]2GK-bU$[{/SR)N}/?p*F-VraJSrcr557x}~օcm='<#)=sۻdSn^L8PκuV~N掻aRlkom+8rr&d~wJN)F=A~ 9g7oz|s \\RT@;)2JW}Yx2 LUmfy%oˇ{u-|JLLgPyfse1tvQCc+F>s\Rx{%nSTWUMN`~x2 8gK:[YU)py/a~tskӁjk+ܮVon=ZrsGm.ߢP! qgWgs~=I}B8|1 gxzWv7e}$WEdfTug]ڬn@hIׅi߿?"6)qCS/%i;˷V2WgM|K ջ߫78qJ%?xTɎMوIw3@EU7n\28G#sqTjb2 ߟ:n t(ood# +N3bmE\t[LnOϞ.xJa6}%-I7-NU~~w|)+S I+zq/jCQ513nsi1e-gbr4:N[t y̷|ujg>F&DUyQ`n 68gC3nدE2U_pfW3\uikXēYmsBE 4) IwN}/iICLjDjEZȼtϚ0Uw=$3c^Sܴ*C~W6:vư9eA4*Ql *mn/jQ;Ԕi2'ɹ2]iU?!S=Wgѝ=j;(2Dk8ڋϞ?UM6 1Xr0@ eipu40i]PGZb-,jg 4x8&"c&B-$>̉FU{^Ys iDflFutTn뽽ڝ8:ʷ67z$yvBbLMq8&/2Zq$Z0$~dQx%LGoG7vp R&dž}q YpxI4!>{T* ijJ2Id:lhI' :Pd\l/;{(OeYw4zښflBM2b+0sb0V7tbӕ)Ҵa+>cKk\r9_&k K3 ^Et/*B8UոF}ҲsF~f1Y80964q#ei'87ι/uxCQ ͜:3|~zPR˸^!L-k7'G/ԊKlj7r'%9iaٰ64\ܥbf{ӑwkZxEUg] 6o{p0Vޜs =7\z:;7TCX@dC) J~%UZZY]qP{pآ 4aNDƖGWԻݐ2.6rpK1u62B(:ɽ,f'!8w=.;ٴ-jh욲:!KRto]n@JpEG"tÇ|yjsl^/]W0;b;҈]oAb&,5;xS؄u F X/l.=UguM^PE0L5JKø# `*Pj!n<s&~QWVq8wۉҽRNңwꥦg^wh{nbl:Z, n2;$,sAUQ2x6"E,p- $&N=\r MȻ 誯Fϩo/Nz#\M)M~r˂%<~AϺ鍜tuySqoYs֚=Vozo- Y\w}g?d?/'*[NS%zk 8}\PQt\ VW(?v |OQbMe-Wpv[[w 9tOy5z%[,ٜFl-{*{Uw|v6TaQk9Jn9go}XcCKϜ(gf4RwKmjvuK l^ȳ К6 v'+}%N4ֹCrb 쩿5UZܱZdnJߥ{r6K{׌bjo.?`UE Wyua7`ɇ jyܕt[ |q48w@h8l'6/Xec$F;LM\RJ72H"dxN;vn77ZbAB(P6ˍ^n% @o#*~FH_\*sv-q.P\ pa#g[K;-Ψ\:ttn2pdv8yCԿ_wJaIJLXnS6ohcG2@࠘&8x-Q^(.OaMJyWHD =RԴ9*ݎO8m4k䏏h҆K؈}fkY}kgXaiO {Uת {'%Pum;N2OS SeZ1jO}g'O1s|.`7c%nLܜQ7=V{1&j" K#O"^kOS;fZȹUx4Z@DO°;G*/;{='4g\xRjthm :j(c&>P UƏT:5WU `r4jEv7Cp`)mm--a84CKu7F3"/YG3[%#{嫏nfq3)\N TFV}H F l8n=c JY I?\ODHscz@hV tp^o`HXR-[/O6r6G{n}v0?cֿO)b冮s]Fݑr -n]V *n2s+RЛrΏ fG&D G"2Mm 6$EMQ {5b&^ĜVdvVۣ?EkEx.|92@jIM-^Ŝ^i3X@pmf#ǁ#.s3l. l&.[ $n8w=\$}a=a/idj c2]y= `E&elpyҁRhXʹ?._>|GE7x~ZZre ܿ^=-UʷwJ`mwd_"h8wԩ+Ά (?ܯ}RF,?{ظnN)^<۬!sOb|\ FC &R’yxlt<.7WoKXEǽo~8lk @KMn74E.Sco@Ы!!WH [icY@QNLWge4t츨0XkJ^4l"N}7GMQ-`u9''ngvEko<+)x{k}IwkMV_>T׶ WFB %4j}(4+N:4hQBpr4.?}<8&|TZnl6pu:u4Gzύ>7ڇ5匮{aoKZNt=.1ChVLѬ4|voqB&}aZBJ*n?;W887?Y>y׏eUOtt,c'C" ۜ q•y,8)V(YtRv8uwB $ mudGjz"Vqp59oC]9qaBTZ45guͭ&^O(2.],4ux֖| Ґ7.usszǁn/铈ȡ+YFq8 \lpZ1ifKL`DC<ڹ3ShJ=D2@842.UPQ=a/ ɐs,  DSOzB?⃲O6|b8KN71736fԨM[F3b5M =ܷ 7^Q2+ƍ1uH&1ڸy~bΞ;CEg hQdDmhW>֪Y[祵X#MQ4 'N׭34BOKq(cF,MWh=Vdhp|L9m>r+v3mQkGK"k Dlܩ7("B4i^Lv}C+KEQ9VYBXeSkR̈gO-4KDDsPe~_(s~4VwHR6%L+k;(R)/ӦF.|ܿ|<ݝuxaKnc&# ~#cgHE3(_߇s^ȇF 9?<ͽ;F Jcsi(i }轔9ys|q9 <9y>h9Eг<9yA{k2<9y>(K<97 ̑J<97p <-xs<@|y <93=,<9y>98<9ysx/[q=!s< #L'ys烙6t§-<9ysr4ڍ ys<9Bt"Xxs<B`}<9=z){<9y>9Ņ&xs< [Axs<sxs<̼K9ܔs8>9ys|s*ϐ<9y_^8<9yszNq!@xs<̜ D<9yA+B ҿ8<9?G<9= n ys烝>>AP ys <9=8;_<9y)7Er `Y6<9y>9]mV //R׽` q5<9yszNu/ys<Ĝ 9ys<8N'ZtΟ^x% p- ^xEZ!2[|O䅗E{?xstI <9B}GHu9y ,9Q<3L / yrgBZpYŇ?3cߓSSZ/jm$a]NJi<%O)3>Ru |>mbEEy~r;V;C_ ʟ0> _=R&wGNu~M $nzlR䒔TOOL#\G6qi{;* |mkR+_qGO?cxU˚̜Rؼpc1FĒkRg7WƇ]4=>nnnj?$EݟΊ}+WDn=>sTe7׭zkO̼L0݇%dq a|k\ew}M}\|O^G[cmM :Wx]f !q q~Q([{K6FDU??QW]awn߯cSKf#c\t=CUM?wJ;x`{.}߆n)zouzW^+6ʝ7yw?Zky8&g].JPV}3N*j]^\oz۟lR-\4K\ey

ӷY# ws b5Y:^߳Y<9mg*kb>xV}g!g}}5~w?H=7 v{NJ7oZ@v_dcOKiY"{7%3~=lfYkt<78=-)_>gnl6,E`їtiđW:zy{'vf[M[#^_ynWNLӳ1m|eV*q].X`o){_xrU}xY_IY1x|'-ʙТY€wgIuϬiԭ:>@e<1'oO_ɻԿ&uCr[sZ}aQKnk{]WOM9U{!Pkm?菼Jݴ#(kKv8G׿rP/-o땇?f`93NqM4 5C"mwzW&&+z˵* O-45[nxal64Qfmjx5sFGH(9š7Ƈ= /!vc[[jhdc:]^>q|f)~zJ%i:n ;6JUֶz֢ suWXxꎭ| -IZ9=Ӓ'%'vl;QR])"ֆ-ٳdkR_?ya,ɠ۟Ǚ'rm_tKˣӓ䔣Ďs{y_&ǫŰvﹻo,'? 0YܣtD.߶~hPX 7lmmgu׻wz_>)ONP ښV7r[o;M:_??JR aؿˡ?paf^/ONW?ֆ'n`ԉY ah<3lRp=OLn]p}P\L!4lٿ?]vKnl߮L7LxpʸC_{pn< ci>s$PY#N<ڦ{ BO{mٞ]Ǜ-/~յ>1&&*\6޿đ'_{)wg~`8Oߔ1I~i-`NnjId g䐄0ϟ_Cӯ>qÎh-2Ug_[&pvwW/wy5Rgٲ{ GurO]Iޣe:>mi^/g-'}?!5ןܙ\"IWc=' />vXSlwrjl5m&;f66Rι+|slG=5J@ZŃV{6QDbfZt㗟o-;|N٨}[ƫR[s2!ѷ>tq,ߞ<זoZʇ˳rEc8d-Ӳ[]ҕU~/܌xs{,@/,%S>{@wS޺b?6U/X֪_zW}>[]x^ i P~Or[4-jU58[N8ggr:~f([>I]m/Xz_͒6X\ceW%iIٿ׬Xuꭏ__8|Fswuֹ'q7]9U-ݵC5Ybʇ4@yr5RH><3pj_Q&v~恫8mpT|ƖJO;_^w~Ywq;n[Alu/~Z=ĝ~n{/6CU iꏊW>GXkGg<hɇ_lY釋_8U..__b뇩s]xkJ薂Gm/̽O6.b{ >.YVX_ϖq[` F6WtQɦ&ר^`O>];D{3<: 枵R%λޙ#-N5L⦱ a'Ol-i<޼ k>VNj7~^5#ix*O8_>] f46Z# z$$iӯbԚ;ݣ6:Zd;"]gUt> ?8q 3,.ڹ$BIrPmі8+dbobVlL9 xr2`noX|BkeEio\W*O5[ ɘewZZ=$mw8%K(:;laBe/)9 C, 6J(.e~'(7xkkoa36E+fNT갡fĴX~r_8vdz2me~!_}: O"b Z)Rk~WdEjp Z!-WɥMG}e5'k꺼|{e:vɟ=뛭/n048fE40 h}x[duљz|T&b52+B\B J:=7]ᨴ܌p/`h{T(JʝmݾfI_2:E5482L&ci)WI]fyu ӗ?Ir?*z؄qj8cn]"J~L̬]r%ıW\}l-N 'hmkx!PEimTаLd0!)F6V(zǍU&ffE>m)ڰ9"`h :~Ih<]Ml5TX~d%JW?q(pp8\'t:i4^d4!Z!)B~}kryܭ N@=㏱Ugr)TjjMD"T^JD>/}gtX P2UD&Ԛq"B,=@w]N a3Ӓϖow'FD~'x`; X PW8pDIUpތX8n8*C+/h=s˞=~e7GXL $D9.N1༊jkce=BpD7pHHB֡ J@} I;Ry . vwaڛ .;"ڳtǬl{Gr{)x3G i@uq"K&co{ z2˫Ki I64U;_j=7DH?;|aknrBRԀỳ" Df+NJZ+Šwxv4 $c~/B\%'u樹O„KVTarp@B^姶)X v d)I'- a?a^%"pv4ݴD/lƚkWkE5\ p^7V@w]_?vdHDI}#RЭ (4ʾ17=rpK޺ Q~[pV\.q ܉) 9tU 6}M3RnxuE2C U)Ű*vy"dX+UW6y3"X4y]/K&:Z+Jt V;~\!U;_n|zVs̘oWH^!v%B:@vϩ'nݔ_'i$ MmT՚}G[{ EV~Yt{\U?^AOtյc^{\?w4ۧ9L%ek2Ԟ۴|@&2\mh-+X?<-.yBpRuUڄ#'֬ްFW];3=#I:YTg+79\?q uuZ]u]ݧ)L)fV5U}7E_#zt\ƃ7Bw~o >:)Y]ScÆ}5ʓ_9Y(I5.G.<:EHGt5+xe>uƌQ5tյO[|#}xn+N\(U{g5owBR@9\[v8pJ*uwmK}9O$$ʱ4pY4 d~￤䤠c3zWYt- ۧo>$@biJQXT Pw)K/0Sʌ/},{=u[72mƜw d;Zbg%mlbnXϫo=0&SgHGW7N: gH`%!m'v9aԤyp'KIMѪkWah{tl}6cWO҅R48P+K2iAt=wNU:&eP@&S&equmi8utߐ]G.s-MR9,4oĢSiAK8gsw xtE鿟ĉ2p }P⦼ S<[5'<~}3GOq&z"Q̫G|Й.[\O N&8cæv&: fFDŕHAމ<ѩenJr"#"Šcg~ $ԱǠK Hv  "#ŠN^ͭ #)J 0M=yph ȕs\7У SXN E_"# kh_ 3e.FM/ױsd2҅4 tŭuqz=8?MXD*bt2-(f⥇GdصY(w3maox4qgFk׶-4N=O{gS&dF?L!ajS#,J +۸G=7^޿) Tg]q?87ehB'<~4sp)j7S)?ӝ6t0%8_C!Ÿw+c#FHz'>=[zZ* }_gK7CQħ|CQب)yJ|CKW r+(%SlHvޮ7X 'ॅ&Xw1e$'SXn1@׫U+Sfi5lYJ_ЩiCSPT;05r4{#η6MuY4qһbpe|zV|Gim+\ J. OFS7\M71V.2BөyM&Rl- icrjU o\l#{ss4pn NeXnu{X-Z7 bMG\/#|RsjSx˶Qc~#6ՌJ\!|*xۍ6ݿ<_}.;x@ /+xG+ R t)r'Wr1?#574ӥU;9 #5%KNs#Ss ~BnfJBnS{/ }: }"xu8qGXZaj3 8ߗuV\9(N #*N\B=enCqAHq|p#8Fh1|b=$#Rd8WL0B4e$t"8#/]UXGGRV\1jTT[Dq-l>Gʹq+S UGq ]rF2צ%#c*RA߅ƃkY@q-l>G䪆S[#8F\}xU\ʉ8o^Q8 Ql8#8<5ZN#8#+s(CqG) Ep?#㠅'jjpX8(^@?#qۊ71Pa#@2?#qŨQ@=q0q6\=B 4 qGqY #~]U*, 8ߛW ~Gw#DBBBBB-!f # 6'j\cCXGrm"Oո2*!8#/Ή'0C t/!!8?N+ S  ɴXF~GZGqGW{#8\m(YfGqq`8VTF!8#/FS * Aq/GqĿ r9^&"!!@aHH?E4?RMdP)L DWaӥRX"FVtAm D!*Z)ÀEJ(qXtvBtjAK;qGq +1-gA}8E=G/qCR#8eX, C\5J?אPvDWqq%W<#,_x1Af#!i UbxUR!.iGBB0 Tk(8:n*! G3#6Q4R\ˍ8 ^r8ax\9jlVz}Z[ /鵫_aģOwNsi;f Ii(+L {f[/_+7o'( qT~܌WGsr8vbPL vCMkim%^[:?&ڳhu˽<-ʭ 콼S6o_yny ｗ^9߭kV M͟S.>ļێ6w#I|rj ~YqsG ~~._3a,e.ceWͻUw+6SoZsɹAJ~ayaIcW +/M vm1x|x[vGC&}X5!ݛҾ~)ZnK !ɭ¢%4M TE:f]5_5ݕC,sd~<__\R\RqrTA&Ks+MZ.]P/<׮Hʫ~DF$Gf~:D+t^q*82:*:};? QY]MݑZ?2aQBtLfC/NGtPicF?yЯ~~]sboխ/e%5ߔ_!v'kw21K|xџsOq_>8 :O;k nA.ю~V_vt_nK~}3K|~gU~ bVN&) o4U"o]w/V{/Pԓ(MG{2yUҘ[']tI#CVQ) E ^_G߹ǩ'=ss]lLtq`1O?Ұ-ˤSd,[ ___TXėjk\-?%D 9^p,ݹ {~%8]I'\^i\@`6O-@-Sg.}kǜ\Bm5i["WDUG]zxg7߾?hbIgKp\O>~bd1eq ; p\KJǠ8˚ WN5,?qxT"(~vj ]Y8| -yA{uMtg/N2jK.^4Ȋ1rfaǭ I+q)T!yÉV[t%v9+̏|r೟0 `ܜ!YM7eҔ₣Su1Weq69+trn'_ MRMZ|e(p}P(\1ѱ ww'pYq*ǫC B6OEg 1qT73ضҒQ^rY^a8uH&WcO> 6%cGrpew~q`~Ͻ/Q+r~fl岄wfV{)vzq ǣߘ; P)T:E`*b3 R~ JTſ{-ۇLZ(c3YgXrR94DoS [ _vb3YLI~}'H"Ν͐޽uSS;8hjl6EC_9Gqr(:Eb dL*@lrsIJX4@&|slV r%l&`biRq^7Y8HcґbO2<IΝ_L{^U>aҩq- Й,677 :F]n] Pyo[ +Iz&4to;y \_rAd/-qxf ttݚc?U,N|<_ӛ&MV$~z"1g&*h󰵧f0 YϣcS 1FZIFN άru.(^BNe,=Ӗ6!HQԋqI9t@ is2s"ٶFcЧý/+24le6=8k#be;{rē<3tiWtkgAo?Gc c2QQn]fns{6)ݵWS'/1PᢒV,yQ`ٖ164I";pk(ԲW RRӚLd`ڢSK[")IYQW?B$8yȎ/YPP_^v-0iY!v'Fە5 O/)b Ɉi[;@.1uL*=s87FFt;$ǧgbJб:pccE5SV,c.R\rtv@='+&M$,Ώ⿬Ľk@˛77r9;ubyikNiĐYa?F4s:͹r.g9x5q2*=~]gO:@AVK5nLinԛ***dRrt)τMY^,77fVJ:Iʶw>~c6{/?aŗJM2b`fC\Bf`>aV7O&z˟C[o͹Dxr3E3iҼ缸xs"%/o]-hަrP>P S~Qk\.Q[U(GK*PmyvL=|72p\ /Qt,,ݯ|uk7ԩyLH***[\&l-ꪥoБTNwP Zܿ#[֌k@ђD,IiMu\4C ˔'YL&Ey$'~:N޹]oi1i?{T XS43ҩd*y јӻ=5k:W<'\*4n(L-o5nß]/ zohˁ^^&T=4oފwjgg4 ,oL3vi:}ՎeVzд L*.Tuq |oL/%g@o%1s-u8Ťޤyd_XО{hPF%Cc7Y4D$=;Z-o_~OǕ $72)|˖Yy18zn༽NVMziҫY}ޥn]kOwЇhLh7A P P0`D&Uѡ3e!yӷwV/ϣfC[2NS: Eu.uө$\qBյ9f֫6z`nk D<1f/JʬdUvj>r{~_6s7ԛ_4R'\8 7xYnڨa#d.W/oLPcXX7/g$͈-,s˂:ƾtթBa %[j>z,\]wɐ:^q}͍]ؽxÈ&P}pMkYcbwYr2-{綹͗·gE۶2maf(KqHWCqR-.-;lʞל`ff{4\{*druaӥfYylylNi:}[:b?{]ѕnગw!_r|ÞY@;w~=~u!Ҽ+dkϦCųf@֍5~>;vF&G+g|5\9 }С+eMY``ѿy6.M>yu .{;R@>MlܛhgϘ,t7?,$qUCޞ'N ,\ NqjN-t;b=G{F}]=W5ZIe,)fq84-KehXY}& H?9^㺍۷lVq2jթ]/oi5aϚg`zq`F&yաgVl0zВEyWa_<<]>]#{ AS-kڮ+e}{76;9n{mΘwo+R=ZrՁ{{ҔWgo2C<`mF`(m[z.G>ZR9/JO|e> 8._o1Wuzt+ jIc`!m}긯qǥn:5i0qch7S0J3]DNZOܷG^wZp{g "~Q: .>ج~hƭƭn<kĂey@C{gR(8]tSS6Pc_S<u >;D1t:iIo66vkb~ ,oذxQl϶ٰh^mЮ`7 "l!e3lϹsjQ._U]Lċ#6egl𿶁XϚ{9K.<%_xNTKq, 90vc8.#{;[5]FO wpv8= ݊V)Zffgg>9$RDŽbiW!Tؘo#19@5rtCtL S#El=KOb0-&./QgH``htk~ֻ6vj{n?IR>Jd86MӱkX5/'s\Xu[ҔC BॽtS'C3:E"10 ]<%"KOɥ6vQt "?JwmP߀ %Ku=lXUVF *&D aY6qP "b6nu^j)>[AV.lwGIvdR{(LR Tmtb3]rҜb`X8)HYTBW,cb< )7ctP A.FMeRM )IJ_B>ű"#G{KKwWAL\WC#HCu?´b(ZP4+׆H?MmNޱʥruaV.qX46#U"ss˜yu̼\tؘ"ScgsXU~u\ _JyF&JON]@PR !$:H˜beCEb:Y)V4%2pkb_8 B\'3/l?טr~1gzFv>$~hFEqGK9,?W+}IqGqmh@8k?>h !!}iHMxHFWHHHHH5CBBBvd*$},ưb"NZ^>W9}"/iX橽vEIIן  zpc. вAw[:ߐ?ڴcD_\˳1^V?fTO-Xy<ccWo\CWK|'^~S"vU_/ߒݶoY`k̨N|ҁݥincr#xl *š^#kʵ*OYaMAyj?߆?7r9d#6'jzsmyMZĵ!/Nnzx LckRkRq x9X64񰡁a[P5M,'f<'1ql N5m$ڤ%%YB ;d<ЧǟwM#)V~䛧KO|?WF+oۨiqGi=$O>ȱwMq. h4=ϡ= 'r3/uK5p٢nN콕Q@}iҋ{ پ!`o{Dr1х1t}`Se}| ^ҿ˶;u/kE=UIv.: ܻn[fS4e~4A'DŽS@fإÐWHQM8/@p<#'bV]o@"x~~enM/*`߶{cj_rvI b,16vPܔУ;_}&?wfvmka νwb׾ U_,p(9u ~īëB=~+K[8\~̃{w姆 KrZn}qނC"KbDP$Hr S"߾xo_͈yE@9ODgup4BO %޺'[ O *Z," D91;Zp_ +ys PKNf(;"L0~lH(qY?Q"D(Hq\. DBD] DBA'F<& @Vl[sPtsݝ_d闔U_޲iP faBK3c5BH$RO:ycP =y.2jo1Cյ}W&w7ma;71 f}\:vY=|/l^pn8snl ͵C[9[|SNdz6}}9;Vw5֮^OU[vmƄ 0p;zw}zy 'tNW#nʫ&nI`71sGNxN+6R@rdʐW&v2hosbg#A"Mܱ~rq{׼%YOpa]3G#>o5iI;?u;90@h߰ygogY-8>OvoEEhfZ'EC0a8 ˺ʣFmϼz%n-?/3_ƜF#RZyA/d+1oٿqA>m}Tfu}fRy']K}CL_S#\ d[5ρy1ؕ%$60p=Z1ȥM[;EH K$}b,71*>)6Škpq^zTbwL:wݼ)]2*ʹZ~V+qr/)Gϲi֙tl712nzåX 8qeF8RX\Bqvdٻ b)^c`0+=NR>q=bz:97zaG%7%_)禍n ѹ?= ~58 Sі0*ғ>},/N{/d-^.Xױo h]g QlE%z:z7sbT}@&~2WFZSdc(L(J$ScU3Gr%W+42ejK9qD \..>woW*Pu}'EYmJLݹqbc;#呖mR1?89c{kz;e q 3T&æ(5tq58k3ԓ']FO1rLF7vt3W~ٽ>XxQ\mdR 9* b:15}e cv)0#xYYWڴqE|Nz,zxt [x%,0-o妧 U~KV]C^ށ F=թܼ(2>kK)/?}PAJYIT;wSes" )nȝf-۵Bخ%ctlh3uVuJ)O_qҵG5'k%>|(p( ;I'Mӆv0ba@6UY;gQn'=#ARVzP 2?hR8Ur-ػ\82cn)KXҎ}ZMp0`( /LY>V,c+۸/֥Put 9ۙXYHl~f'֯>,$ o@_٥[ kǖ$ذv64S3l9y+d[mO2~۪z5,p%6Iwhg W0eխcmQb߱j.Vt 7%!:1|gҊHn`bMyy]_CC+gK/o բ.p_/钥/.Rغ.ԡ sh,&B-_I q5r.$|6Ӓ|9\aE1MG8V.͌r)&u]}|ݏh:׏4+a˗{CK;҃s׬^hlo6$Zw.;Oxdagn}_5yù6'Jl˭J'L+98|W= {(yvkޝΙ[ Cv~7lz'zИQI[ L|' }">`ܣ˄Ntֱgs &V3v~t\N4woi4nyoa5Bh1f>m 7>kAᚥKk Ffd댾mplܮACGGGp⭛tgv֙4!`P^j@G{#xU\?bW/N4kϖ͛z~8qV ,62L~m^eEbنu[Y{Fq4Œy5uhc,x6Y64 \$`ݶWHXԐ#~īH,-V= /ӻ,`X8z8ٚ@T$q5(pY~jtT\&_ȮbYHzćLQy1S@B1"Ƨ @V˕W=7nk8ݒ!m4Pӛ )x1D Y4 >%IQ{B ȱ3+;"ةa##\#3/pCC 9efj/ /nΦ55äQ)łmDr")_ :DiP,ܜmTT"HIxqџRsخMX*j(%S\XfɑaTkE}au9|6nCH6}~qwdslB:B //iJzh1&le޸ G5޻Mat،4]m(Z!~+שSݟ K6Xn]nC ,#vMCv[G#*GH47)abin\nv5ӑ  td:/'UrSCP$U#gfId:IB<qM]$:DbI!WD'1'UrSCP$ $ՌGâʮџpgpш$WpL Y~U]x\ѱ9qsL Y~G ^5(8pD Mdx06}"^+L H6jpmdx\[U%Oī֑'⥼zaB"D8qS1up3C_C]DAgZ.2?Vի%olZ`?ϣ$r:ÚLd9zK/,?7C1у'l)8G!2']CO zyF爾`Ek]{P E=N-&C/:\GqRqCt9OwVHGMKI3&zL(/3m;O?>q8;) KTw/}1q #,GdR^׾!;~|hl8iݰVtz9M;јtv둳/pIA'mv4r$];%٭lM@~Oda|k[)գ6v<4sl2nd/\ݜ\8WL;Lݔ|x_楾]4ogefdefĿ0OCRIQ^V_"3J$Pzۈ4 ??3D*ggdJЇ7+<###+3ꡇ?]$8#+3#+=#Ź9\--,ʁ鍧,H K{}rZVfFVM;L/O EwvY/LOyynySye'#[ ^˹q]8`8"4~8^in8ZN>>ڻn8Xaެiepbom>ۑm7/ AcfzLh`ТYχnԲ Z.n43G$m'nX= ˏܼlˇ_uEWo2tQ6]3ZN L-}6:dʁNdpcR쿘- ~eݼﰎ xv#z;zW"yn؉NC߁c}-10v۫Waݺv֭Ǫc d|~UF<~">>001j'#;)#G1ƺ  Bg{|9ʫrT) ^N2e80k&CǏH=;IE"6M|R,$)hIH\SbnbsssssVdn chbYژRr)@NhtzٷIR^plK?Wɉ)ԦR.8x-@2?׌Nej©w⁷ϨJ22b"XCE})MS#e 蚙EE~񯟥Lo>qc'^9%@*$SG)dUǛ1(a}|['AyUʉQAJN!nSQc$x8`.5Pڮ`0L/]U/;O5šٛO=91wR ZG gn*(,!1 EKW`y-n>q>26..Q=NG1 Mge$~xyuC <T%/8MttLJfX4~NAĦEDž9u-JkE>@9*R$xxrArA8T#83ZNAx.|}|}Fyu)Zic퇹jپc2 e~KSz/]|ض}|;}W|NMh{ZSq4~.=7vi;~T^izC.ahlO;t5o>U=ܽ%K{9x5x/#"Uz%m_/+qj :aa9n4sfHR>4F]>zjIߊħUsFqأwr+7Ow+ ">&=0@)Zذ/ھ -<,4_cOk/LԱiWO5va/) {iZ džGgJ Y?Zc$~ /#\P,-,`@t`a8(#NfäSAԐ-x1I ^cau9|>I ^N)cpΉs0RA īĀgP;b0Iϱ/GqĿ;qx8y5@2?WsUr 14B89q$k1"I ^cI ^Nr q=$׬sҦ ~9GX 9 (:5) qrsdx :4~1'8I ^NWPby'7WT9A0"I ^SHp#Jqp '5Lj'i ^cJ5k#P-  0EQb8qE@yGO?טIsq'īiP+ˎ,~:N Af\nUs8(bzC\$~ 588N?WS8`RY8ٹk4~1G qd~SE)eEUgPA\AIrE$ī)/8`#N~Nx9`@*?ה8 ^0e4Uqr}J+=BDJnj#Ij#$Oī]M.(!ī)c*ŭ=w89@*?הxM9>$~Z[p@t 9 ^38Ur ajB'?/-`rAfS ĿcF*?Wb(RPI%JqrŽTk'~1'J?W0PUSNj5ĂZQ'Uq 0 Sxu8 m pUⵂ+(HqpA$~Q(HPT*F`6gAZaFQPQ(aMryCZ%# / T0 0 QY&x%⸔Lp/q2r }69)$~1t2-(fHs3#+3lA:J<P>tB\!,~:N%y ^rqT!?UsGb/qRsBĿKx0pŨQ Sje@t\L?RA(G/2A:B,8Nbqs kK'9 ^cʱ6r;B1Lُ %$ 8I ^s,JAk9N2?WK8F889!AΉ58:&N# 0 #]?{d/ {% j]ZG:=V,VNܸs$T>9<;rs/@.n LOl.Y! kzp&w@?LwP`]9@ C;6_O4d zph3.謻!b zx9.yaL?D&B@ez[o7U6T 3K3c:rEFaz[.neߍ'7ث&Fbٖ4JT֖L?QcY_ŠB/vOǧTZLsdM<.Dz >E8TiBT[WQ,,8T҂A!j QCCbiKܽ"Y+yGiF6{RXSYr̍_Wjj$ č5 0fh_)*VhlShZR_]$-̈8C'4_`=WէyOv+_M1u\R[X2m^[W?p{{(5aդQ>rzQ#G}ө'h>?ndʔj =3]Į?pac-q - vM8}5*ER-7\>ggK-^gާsמrmGr)^P|{/cj[K0{籕7ۿQ3\}^ޔsΘc6J(u\!y٣&L~Xo/ʸ|t皾1- ⿥]kh0{Ӕ1WQ-qc͓ 5NGx+En~>a7 {=}o'm;ÿv+?`{ۭxo& H{R ̽p"m/|gtр6SJ|藕>D;|.޳m[?mJg/aw9ocyK>,|7 9׎[ ^8йcXsу[bJ '.tQ{04/guu~dMXݹw#+G LP B󼚱G\F,dF5KIf?{S<]X2'3\cs𾣔6՟02!ݱ7Nv@Ɣ˖'%.r^ݹċfx.Yl`~QL}sy2gsE1^>Ԃf BH&,%Lر~I_fՆL`guIXi]>t2 :v/Fi()yvf+*9?,g5ӣhĿ&{ G a[Eh_ܸ[*?| (*a՝;wU"KK%}fL{}fC-D$߻tfk/yr0}qw/gEKsDB&aG[yR"%=Iq=b:kQ2 <:bd\-_۲} RhyK}lg7n?Gݚ Zq<:q 7Ε5W-xr68 Վ]ݶtˑj._^28 N1 2)C%ۡƓB}y3k R|zρÍN%%J:N/d*M^S.^aEĹ> eU^p*)X8O82 !_IH8u}LEk7DyWر~ȴ NڮdUk /]=s4v~yz"4j ?}]uo/?R8}TҒ1'v'i&=Zp*)ᷕ&7ݕUcC= ޳O9<5BXSʍ;MfCɿ]WO8pG;5J%u N%m?*/nr4"'ܶ^(nٺvzl6st&nKsSi^vYeR(K-|[:8֓B'PM7Ϝ?GGRܮu*Հ?cQe~櫈bQ7վWA?ᣙQ'0zJ\]_UnL#_2~Ԁq#|Ŭ5"JQHr̷{|Rž a̲dԨJ^q}žSI ;{ ff:auOq󡤄SIC\͓o*gGvkdY\©_Wd7am©ˇ%G?9֍V.xt.x@ :Hг+反4cKPgo|=$ sWm&NJ6s.%93i{.=m0$U7R Ф[] Y=P~ ν~iB~f?yw/׾}Q!@b|ug(bܚj[tҾV9C?rbց \b=EO.;; VOgmD7ߕOj싞$ȣw%ڔ};NXY20ЄzF{?zjnSf\< qrvW/[+]>e(*!Ѹ%f!\~w㋻OJ5ʨZ&Z:سdڈ@P:Σ@b;{8DJ!B>xۿ0s5~ LV_z\1Oggr܏ϯw`bDxlczsLsw7mWw`ݶW ktpbiQfaC S` H _mMDRӺVy1'^6ߦN2J"Q4_\HFdZ;KxERR>q W;:wG{4\( s-씸qm-+@|ɿ⮧VVX6d 0ζ C+zX>_^#3Wo11 'gtѫ b|Ës̷ەGs'x`⚇rfWN!~ڹ|7#GSMh{Mss^=|{,{r|Zq;Q2@ɵ=Si,fc*ˌמ+yTO7vt4J X5dD?/J*~xU <.)SfjXh/jNyl>B@ڃZZPpC%)չׯʊ@ 5ԕܮQF$CdsO55PIWOs@7"rN| *D] Dgn_alCڇ]@h6!SOl7G^P*j~+6~~RJEj"D$ۄ-xr>v63jb @ o3Ip$#c㖲{69so,_pe4i^ŦO0uՓQw#tr =}TG66fPdf\?M"Z{<"m7J ~LqA@+_o;GUvb Xܭg{ZJݹ.L_o+B|H#>(},Mc WmCxZ*B0oǗ[J)-}\~WqjaPqI;q#WE3dN&i4rU"^ѓaR*R$I!noMш=8  RJz&zC_4S/K?sx{w`Apy|GVan*H/xűx~eAe"(D"Q8jWWѨty#IPaa)W$Ssk6 _ҏVAn^מ$@pTh{`4ToI+S/&cHwȣ>k+`“={gC%4O&u~^-8Yys[ARQX|w3"{8.o;/Ts=n~i& 6;q~q΂rqʢҠp; ';WfҮyՉ|w#[dP4=o4nW va>n kO1Tzwal¡Vmzf  ʭ5+2-^#_Wz=t[w#/N5雾Tp̖AIKytw|k_ s"0 h=[ަ{~cr^[Bv}eosLWV͈X1w/req7եEߦǾKf|}plmÆ;G~;c$1O I _7e|RS؄_<'%,iݜp/cjY?T?tfdM9y.Z GC-2p&]%Z9ى4;]1 w}׏Չ,ט飼-)s%|4W?9~%|[FR^$$2[+#J|MǂAF[yǙ!Q̞:ƔH/g{B! -Nɕ"hDLAb+\725hn;{~S`t4QA}I#Oݸ~eSiLr7ܳo!ݪWtO9'E.6t&TmX0Iui=RS!1`RI59 L:hќg%\Dd _ph"3d"ē^RULG1ebAy=l!MeRwD3 !c%!d0 \&j@ouI~P͔,$F=|@%,/ey{ZR󫊛).=ƒ6= ;K,0!DK-R$Ǥ {(C(_u%lM*S Ŋ7ٿVwߞNĒ \29Vl? _ZQTE3Ts׏#LRW ~Ȁ^k= '6e5ݻ a$[KؼG7c*?_?;q >)|AVZ{׆Bjam c1a~8nؽϜf y:d qEoW7WfqDc)!L0iD={EuN.+*ӁGғV̴@ r4!)n,kI"Nݾ~c2]n9cj=m/z u2<﷉JY^S/W.iP"d &Ly<m8&Օg,Iaa9'o)AJ*5 0%T 05;of;җ+Kcxٰ tKʘJ&5.inKkw[lFF^ig >TCcH7 ׸$=;7T2*d(7K"2(;[堙Q Fod]Kżu_$<~Ȇ `l0Uw:`8zx& 6N4/ViI00=ĵa0N &çoir1(/\3, GO_n AO9Ȁ-+x}`h#^-xpdٸ~5F\y A;moCvҏ>q #iWl{{qګZR$H;S˸\3t;休T(oG-(~&SY=*yK'U)WgVM:^X)O?ƁWyrObnʕT^ޛI߅knAڽ?mM\"(ORIbE?gHl\pI%}}+>vCqiq?Q1a{%$)~h>2.^siN0kJխ5tF{ac#wkR˩V)I{óJCRRuLjKxqrP.c}ݤH*@]ûW5;mfNml:sOR9i?7H]\ko f"0kn@+Key7X[KIK^ q-YgKS*NG=h }ܪ iRJPV74;{'#2NS\TYR"Pl)Ԋƪ._ tKog[")xyb[G7 NSP_!8ّfx&]0YTsw';* %&.6dP/K#ZTRZNa%u@1qtq4#6Б}sevΚL`j"O0MJZRU\(pKFT< s|ş -5 B̬mtظ2if ~Ҏt@PWP\gZY2je*iI3 yۛKx3&jzx0KKMm̵SJk5bi⠖+K9ccxKhoƣ{[viR1舾[W*G*Jj+m}$WBUaf:C!ʿנ!LuԆiْ GVW(<ՕDX]ܼGyQ ?6Xl`%Q>L\P\.+ ⺬[5EIqp27"j+xyمR@xS[{sjk?1lM%urYv ok* _uw@0m[/bKs?/7ۻ׈oLyޚtzjnib?H 0^|K37ރBaXu_TtcWωu)ם˔`:U090>aWNHYGu__x6ّm@~}t((}eΓ6-" И?Ł'$"h~qa傭1OP%X%>ǯ۶6ĒsMAoϺvu- Am3f>޸㛠G~5y vlϬi u>3vmA^0$ZaKP}sG+ Yd* 0B>YjDk:!V]d@X f\xT8GV4%I+`wC7V ['cʎ:) xJen1A%|P˛nϺسϠ!)/i5>?%Όyyo+ve'jxc/>_ݯ0Y]#dfG?4S7 B;o&gK6d3=ɇe+h@!L-UI" ð+?5LwOuɽs5E\>6څrVm'> PM{eMewY^Kf?ťSE6wqYDݺX , :_ d`gmC-bA.\w9"@m=q`𪄸ĸL*lwÆ?)=~4EHbZ‰!2ʯ;?/1.>1m=/^.e|c3F[,'-2.kzyQr7;ZM9oͭ<>m@:+-]BX3yAc~~9 %>1.Բ78C%ɵ@M4 ܬbsr^wO-'1.>qzuIT?>6vl8ȶqjW.$=i/BAm_7ju\|b\|DvΎ=j$N+E@]N8-;_@]vOaR|wm nj)5€ J?yʭ)yk*gĸɽZm~&!'q,Oyr!Oew'gO*T(ɉ}?|^:ߖG14̺ ݺ$S1.>Om:yY7VI.>1.!i~:l՚m#-#'.{$qlZ%E8{v}5/Onj< .uYO?>7@ KE>૟!Eژ]#0M{_\ٴOR@P~LZE;l`[A[6'>1.>q_ޒpU$޽W~c,݉{P~ _uwbmHZJR<ω]1}F\p Zr݄Dd;zYRq~42hL ˢׯ'zK ܦf"EV*퉙gO?-8"v_Ɣ~lK -Fm`k2s*UDC\S, ϓA;(s.-L6*٭8+QT$'?h@ʼ%M ^󧷍HP%jKglotlo磾|.Yw&98ٺݷQ O>S"sbHIq^i%ƴrs@@Q(|QT))xr48)G"rQ/bo~hԥ|G$UJ OAq zʊp:1њ8u u0.0x> "[X?s[a2qMdRyX/>&Ń&@ǯ"An*MM^nc3rvʸ!C[*"MT z`a,P𲞲E1..#,,JsȩƱO^:󳑁~Vgr}|Ly FMx/TYWT+V+Dt;jDH& _uwjLk44\o5RۛꌀAa4r+:{=?`st<wSsɦj|3{u;h\ٍͥ%^u@&@"hQ%o:U@paqŴ<9>k?}ʄ݁ CFu=d<(d|ήEc$bDԒ頃~f>'NZwߊ4v@ڍĂfYyFۜ1$b/3Vyĭ6 .K?Wƛs0l/AdZX[Q*<|xMaqj5ncFըSc?y{qw9EsFDp8RJJB~Jm>ho`9tfFU\:.Ơ'wS@]ug4 +~jDR0l}F[е@g8^Q]~0ڄ*zA?#MS*q,^6na2՘MA`⧸#077JۭH|iYO=2v6m{ز/6Mݍ{K>׎8]^^o74uiipEdE] dYsf|jAQ<لe/Б.~=w'Ksiom?vp<g6~۷9' Tј+a!Y5>|'2۟ɾO Op]>hdj 89)Sf$czp DJ^7[e}5o;w6m1r0yƵ1 0 >Y[bԂ䉂F9a*Qà |WEp]g󣷢[/qs0S_ >(2g?e1fYV{[;tg9Fu5nDY]T{wG0ޖcϱc6礷0E`pX˭{Ҟ0]LY,}_|- ä)KZ𶜀OV`",r>~cG-᫹VS#1}-jJS {9*'_& 9utzrFw/#[pO;G b@K] \^W7bJ;18aMD6.M+J G$^-WO P D^raܒITLg_ڂ'Or1 Yk%¶F6{tiGm~<-J^:ߞG1nѫ򎝻Yh702mUϟv5^PQ(a$'<:3bf8rX‚4@JJy*e=տ%niI+UX8rm9L#2,9=V,څ͚_*df :wc nICrRg¢spܼLH~hE`4־mc0W޵|r JyQ4MtVr <-%[Ҝ5^߽:%҄2aU6e-[+)=t VO#ۮ4#JސLqS+kPB'2[:ђ.- *ZOL_[=(xJ9ŁwtOt1anDewc`@vGgFЛ$lǺTKں2՚\֐}lG <{Ǭ~dT 3 D+gs=k2OYuz:_f5O8Ԓg o(gϲ`K#$8r`bDڒڳhm]/?@3۾1nnػxV1`j\_ח.;[nU7_xI3OҷCTnCc[>Jd +&$ RR^Pn٭^G*WZLiǁ(&4ڝ& On9=8POB@2\&U&OLq7c5h]RZP 2o6ljCff#Gx#@«,+Qv0!2{ߑ֨EQ\&.9C4ciM}GCLH *g/!cmzJ)E.}GD^|:?ϙFd"m՞le;1L!@HTVUXDvŭȭe2<Άu~x gbmV&"66"A"2bb{G2)W7e2[xf_>v"{ȔL_SʅM2h:q垑!8isjn\fط)ˣWoRL5a u\uPt/6Qٮ{5rrNk~d5{Z 29e𬙟tKyghRR(^RYw u`diI*":}h],ww_(-h,Qw/H7dngeL%Kw{Қl(-@tw#Ĵhf !;[+GG Pt6]p9hj(zxgy[* CO4]twj1Adr7L]Fj ^* AO_o AO}6-t=xB4``X7tڷD'vH) IK9rZoHEv\]~cϱOD%&) r0 F, +0 #zDf Bөxz Q3_ak_% ʠ(8D*^~.qb@} Hg0iW1T(ȁabBĽ;׫Vy|50v᭫ DO+\mC]eҡ4[!2f1{2A*Ee' /ү_d֋7擯<ɓ(^_Pqh<}9mލo0a]=3 |gJ= ^E{ X ɗU TcL18ܮcb47qer+3'˔Y ngt WMxw3e4mm5,nYeI'R ӯpe7^q hܒY\`lO!i|dgnQMF0v kkg:N~\)f8 w-w-˚'``Ҽu {8&m `V6חURU=JnyAXxlƢRCLWFBjzRVn//) :ecQүeL!jeJXK/jjϜVC8ݜ{1  FVXRi[S)uq'2_X\bVȸzP­qs! 9 !^KO^TҮ:s_'mZ:-k?h 7f؁t**7jo2v_2bƔw46㉝_Ξp^]׿sΥol~ܶbUTB7qѯk9 JyD_ 9%6(8N%JZFXZoI~!zԏ\ӫsAcQ]xцkt6A\y]zCdB=CŠyGbs+ WسKR Z#*|cnm2Eع}ܡ-ܬw~=oL1/@⠩NzϞgys2-6ƿ;vxrZ) O$=hro8<h3<%  Sj8w3¼8)[C+*=7 7BH'?_Yav{Woo[xVfnem\ڗKtNUnZTo²6UY;.ݸꫮz~\Jꑿs]qłFo*s̚ ^$pv~Cꐬt"_sϙPsiaAz3O29eI1`-/D<~mz~7ܷ7~cΐԆտT}J?8qP~Sㅬ=6>VI~LH_ ;MH}bޏݱ(U;孽<>>mۿNԬD5JՅ?Ί6*v.>1qxT4=0r~in#MkÓx{-\!G|_ioe-|[ L'BxvybqC#l/9-}9Syιե=k6]]r [Rc/ 8%8_өͫdžNB=WRZH=Q*@qJ ܅׬Kϳr{_{5, ӣvP]|tIտsLd gTNqBY.'&U^p͙GPm |Uɝ6_46g9c VZ2~gL] 'mXʴ)f:%vL\Go?`k~/ |z¼q&SꦅxZx|#BU9`.7H{c>|mقSSN(7O=jk!ATsUl޺nŚ]|;FTqaq.FȷhB*ΒKaS<%gYYjaܛg|!8Թ:Oh-lJyяDa)3+LG z->y3Ǐ q/N?zϮK2N^u ?x|]W#zeK*ҳrL}9oYޭC!Jtp{NTL[NP{5/xqQC7;|SEPTR!;_m䍷}=erݽOHx!:˹<՜-Zmu͔6[˝D"zo {1p- !D0.uoj_kPTHi06JyJiZ Rwp&+}-C @^P 6D~<20֗ʈ0O}n/ ;?&MIw+~dԡSsʷExRyԧڅ*Pk);z`wQqm7 %yr5vZA(UV]mG0-`=^g JRj0/.!R8nuwjP}z(>TᮄPg&?ufJLͩ,EN2 B~d\9d5M蘬iKd +Z%3/OzΘ KvzCF Q2 B'">6X)#eJC@]6^OH9|yTF4@]asvZKk[aQ?kxu-{4sVWL5qpZU% iT[)/?t@eCAO~&`uOVڽgڨ|b=^儣kI-_g$n~eND&zb̡ 9ۃBRO/suEFV.縸^eDF2h;`Z6,*ҮTp'vϴi: {o#EzIsJ080[/P,S&O%# zJq6ң}ô__'9a̐eHȞlɩ+& )I]E?8^ҿz$bmakR"p[8w2aq[pBoHDr7B*L7'ƥHJnJ)amgxSnlfG)a{6PwF(=n.3 endstream endobj 72 0 obj << /Type /Annot /Subtype /Link /A 73 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 177.0863 260.2500 312.0863 ] >> endobj 73 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig1.jpg) >> endobj 74 0 obj << /Type /XObject /Subtype /Image /Width 600 /Height 301 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 600 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 781>> stream xA 0 =" ʝ<2;EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$Ebw endstream endobj 75 0 obj << /Type /XObject /Subtype /Image /Width 600 /Height 301 /SMask 74 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 600 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 58662>> stream xw|TU=IB "`Æk_׊+뺺VֲV,4:RB'HϤM&}2IfRPWTx;<99;gfw^x^~TM p<9ysnNNp <9yszNqS\&p<9yszNG@xs</8|ys烚38@Kys烖S8)4]<9y>9:$8^<9y>9ECGB@xs<$! {"BH,;,& +U4~'٬f@mpT˲EpZ<a%on[D*H?fV*K)j@}e[-H;. b%a,K1߱]xs_!Ctx]m-ŏ׆+zwo;gdt|]2GK-bU$[{/SR)N}/?p*F-VraJSrcr557x}~օcm='<#)=sۻdSn^L8PκuV~N掻aRlkom+8rr&d~wJN)F=A~ 9g7oz|s \\RT@;)2JW}Yx2 LUmfy%oˇ{u-|JLLgPyfse1tvQCc+F>s\Rx{%nSTWUMN`~x2 8gK:[YU)py/a~tskӁjk+ܮVon=ZrsGm.ߢP! qgWgs~=I}B8|1 gxzWv7e}$WEdfTug]ڬn@hIׅi߿?"6)qCS/%i;˷V2WgM|K ջ߫78qJ%?xTɎMوIw3@EU7n\28G#sqTjb2 ߟ:n t(ood# +N3bmE\t[LnOϞ.xJa6}%-I7-NU~~w|)+S I+zq/jCQ513nsi1e-gbr4:N[t y̷|ujg>F&DUyQ`n 68gC3nدE2U_pfW3\uikXēYmsBE 4) IwN}/iICLjDjEZȼtϚ0Uw=$3c^Sܴ*C~W6:vư9eA4*Ql *mn/jQ;Ԕi2'ɹ2]iU?!S=Wgѝ=j;(2Dk8ڋϞ?UM6 1Xr0@ eipu40i]PGZb-,jg 4x8&"c&B-$>̉FU{^Ys iDflFutTn뽽ڝ8:ʷ67z$yvBbLMq8&/2Zq$Z0$~dQx%LGoG7vp R&dž}q YpxI4!>{T* ijJ2Id:lhI' :Pd\l/;{(OeYw4zښflBM2b+0sb0V7tbӕ)Ҵa+>cKk\r9_&k K3 ^Et/*B8UոF}ҲsF~f1Y80964q#ei'87ι/uxCQ ͜:3|~zPR˸^!L-k7'G/ԊKlj7r'%9iaٰ64\ܥbf{ӑwkZxEUg] 6o{p0Vޜs =7\z:;7TCX@dC) J~%UZZY]qP{pآ 4aNDƖGWԻݐ2.6rpK1u62B(:ɽ,f'!8w=.;ٴ-jh욲:!KRto]n@JpEG"tÇ|yjsl^/]W0;b;҈]oAb&,5;xS؄u F X/l.=UguM^PE0L5JKø# `*Pj!n<s&~QWVq8wۉҽRNңwꥦg^wh{nbl:Z, n2;$,sAUQ2x6"E,p- $&N=\r MȻ 誯Fϩo/Nz#\M)M~r˂%<~AϺ鍜tuySqoYs֚=Vozo- Y\w}g?d?/'*[NS%zk 8}\PQt\ VW(?v |OQbMe-Wpv[[w 9tOy5z%[,ٜFl-{*{Uw|v6TaQk9Jn9go}XcCKϜ(gf4RwKmjvuK l^ȳ К6 v'+}%N4ֹCrb 쩿5UZܱZdnJߥ{r6K{׌bjo.?`UE Wyua7`ɇ jyܕt[ |q48w@h8l'6/Xec$F;LM\RJ72H"dxN;vn77ZbAB(P6ˍ^n% @o#*~FH_\*sv-q.P\ pa#g[K;-Ψ\:ttn2pdv8yCԿ_wJaIJLXnS6ohcG2@࠘&8x-Q^(.OaMJyWHD =RԴ9*ݎO8m4k䏏h҆K؈}fkY}kgXaiO {Uת {'%Pum;N2OS SeZ1jO}g'O1s|.`7c%nLܜQ7=V{1&j" K#O"^kOS;fZȹUx4Z@DO°;G*/;{='4g\xRjthm :j(c&>P UƏT:5WU `r4jEv7Cp`)mm--a84CKu7F3"/YG3[%#{嫏nfq3)\N TFV}H F l8n=c JY I?\ODHscz@hV tp^o`HXR-[/O6r6G{n}v0?cֿO)b冮s]Fݑr -n]V *n2s+RЛrΏ fG&D G"2Mm 6$EMQ {5b&^ĜVdvVۣ?EkEx.|92@jIM-^Ŝ^i3X@pmf#ǁ#.s3l. l&.[ $n8w=\$}a=a/idj c2]y= `E&elpyҁRhXʹ?._>|GE7x~ZZre ܿ^=-UʷwJ`mwd_"h8wԩ+Ά (?ܯ}RF,?{ظnN)^<۬!sOb|\ FC &R’yxlt<.7WoKXEǽo~8lk @KMn74E.Sco@Ы!!WH [icY@QNLWge4t츨0XkJ^4l"N}7GMQ-`u9''ngvEko<+)x{k}IwkMV_>T׶ WFB %4j}(4+N:4hQBpr4.?}<8&|TZnl6pu:u4Gzύ>7ڇ5匮{aoKZNt=.1ChVLѬ4|voqB&}aZBJ*n?;W887?Y>y׏eUOtt,c'C" ۜ q•y,8)V(YtRv8uwB $ mudGjz"Vqp59oC]9qaBTZ45guͭ&^O(2.],4ux֖| Ґ7.usszǁn/铈ȡ+YFq8 \lpZ1ifKL`DC<ڹ3ShJ=D2@842.UPQ=a/ ɐs,  DSOzB?⃲O6|b8KN71736fԨM[F3b5M =ܷ 7^Q2+ƍ1uH&1ڸy~bΞ;CEg hQdDmhW>֪Y[祵X#MQ4 'N׭34BOKq(cF,MWh=Vdhp|L9m>r+v3mQkGK"k Dlܩ7("B4i^Lv}C+KEQ9VYBXeSkR̈gO-4KDDsPe~_(s~4VwHR6%L+k;(R)/ӦF.|ܿ|<ݝuxaKnc&# ~#cgHE3(_߇s^ȇF 9?<ͽ;F Jcsi(i }轔9ys|q9 <9y>h9Eг<9yA{k2<9y>(K<97 ̑J<97p <-xs<@|y <93=,<9y>98<9ysx/[q=!s< #L'ys烙6t§-<9ysr4ڍ ys<9Bt"Xxs<B`}<9=z){<9y>9Ņ&xs< [Axs<sxs<̼K9ܔs8>9ys|s*ϐ<9y_^8<9yszNq!@xs<̜ D<9yA+B ҿ8<9?G<9= n ys烝>>AP ys <9=8;_<9y)7Er `Y6<9y>9]mV //R׽` q5<9yszNu/ys<Ĝ 9ys<8N'ZtΟ^x% p- ^xEZ!2[|O䅗E{?xstI <9B}GHu9y ,9Q<3L / yrgBZpYŇ?3cߓSSZ/jm$a]NJi<%O)3>Ru |>mbEEy~r;V;C_ ʟ0> _=R&wGNu~M $nzlR䒔TOOL#\G6qi{;* |mkR+_qGO?cxU˚̜Rؼpc1FĒkRg7WƇ]4=>nnnj?$EݟΊ}+WDn=>sTe7׭zkO̼L0݇%dq a|k\ew}M}\|O^G[cmM :Wx]f !q q~Q([{K6FDU??QW]awn߯cSKf#c\t=CUM?wJ;x`{.}߆n)zouzW^+6ʝ7yw?Zky8&g].JPV}3N*j]^\oz۟lR-\4K\ey

ӷY# ws b5Y:^߳Y<9mg*kb>xV}g!g}}5~w?H=7 v{NJ7oZ@v_dcOKiY"{7%3~=lfYkt<78=-)_>gnl6,E`їtiđW:zy{'vf[M[#^_ynWNLӳ1m|eV*q].X`o){_xrU}xY_IY1x|'-ʙТY€wgIuϬiԭ:>@e<1'oO_ɻԿ&uCr[sZ}aQKnk{]WOM9U{!Pkm?菼Jݴ#(kKv8G׿rP/-o땇?f`93NqM4 5C"mwzW&&+z˵* O-45[nxal64Qfmjx5sFGH(9š7Ƈ= /!vc[[jhdc:]^>q|f)~zJ%i:n ;6JUֶz֢ suWXxꎭ| -IZ9=Ӓ'%'vl;QR])"ֆ-ٳdkR_?ya,ɠ۟Ǚ'rm_tKˣӓ䔣Ďs{y_&ǫŰvﹻo,'? 0YܣtD.߶~hPX 7lmmgu׻wz_>)ONP ښV7r[o;M:_??JR aؿˡ?paf^/ONW?ֆ'n`ԉY ah<3lRp=OLn]p}P\L!4lٿ?]vKnl߮L7LxpʸC_{pn< ci>s$PY#N<ڦ{ BO{mٞ]Ǜ-/~յ>1&&*\6޿đ'_{)wg~`8Oߔ1I~i-`NnjId g䐄0ϟ_Cӯ>qÎh-2Ug_[&pvwW/wy5Rgٲ{ GurO]Iޣe:>mi^/g-'}?!5ןܙ\"IWc=' />vXSlwrjl5m&;f66Rι+|slG=5J@ZŃV{6QDbfZt㗟o-;|N٨}[ƫR[s2!ѷ>tq,ߞ<זoZʇ˳rEc8d-Ӳ[]ҕU~/܌xs{,@/,%S>{@wS޺b?6U/X֪_zW}>[]x^ i P~Or[4-jU58[N8ggr:~f([>I]m/Xz_͒6X\ceW%iIٿ׬Xuꭏ__8|Fswuֹ'q7]9U-ݵC5Ybʇ4@yr5RH><3pj_Q&v~恫8mpT|ƖJO;_^w~Ywq;n[Alu/~Z=ĝ~n{/6CU iꏊW>GXkGg<hɇ_lY釋_8U..__b뇩s]xkJ薂Gm/̽O6.b{ >.YVX_ϖq[` F6WtQɦ&ר^`O>];D{3<: 枵R%λޙ#-N5L⦱ a'Ol-i<޼ k>VNj7~^5#ix*O8_>] f46Z# z$$iӯbԚ;ݣ6:Zd;"]gUt> ?8q 3,.ڹ$BIrPmі8+dbobVlL9 xr2`noX|BkeEio\W*O5[ ɘewZZ=$mw8%K(:;laBe/)9 C, 6J(.e~'(7xkkoa36E+fNT갡fĴX~r_8vdz2me~!_}: O"b Z)Rk~WdEjp Z!-WɥMG}e5'k꺼|{e:vɟ=뛭/n048fE40 h}x[duљz|T&b52+B\B J:=7]ᨴ܌p/`h{T(JʝmݾfI_2:E5482L&ci)WI]fyu ӗ?Ir?*z؄qj8cn]"J~L̬]r%ıW\}l-N 'hmkx!PEimTаLd0!)F6V(zǍU&ffE>m)ڰ9"`h :~Ih<]Ml5TX~d%JW?q(pp8\'t:i4^d4!Z!)B~}kryܭ N@=㏱Ugr)TjjMD"T^JD>/}gtX P2UD&Ԛq"B,=@w]N a3Ӓϖow'FD~'x`; X PW8pDIUpތX8n8*C+/h=s˞=~e7GXL $D9.N1༊jkce=BpD7pHHB֡ J@} I;Ry . vwaڛ .;"ڳtǬl{Gr{)x3G i@uq"K&co{ z2˫Ki I64U;_j=7DH?;|aknrBRԀỳ" Df+NJZ+Šwxv4 $c~/B\%'u樹O„KVTarp@B^姶)X v d)I'- a?a^%"pv4ݴD/lƚkWkE5\ p^7V@w]_?vdHDI}#RЭ (4ʾ17=rpK޺ Q~[pV\.q ܉) 9tU 6}M3RnxuE2C U)Ű*vy"dX+UW6y3"X4y]/K&:Z+Jt V;~\!U;_n|zVs̘oWH^!v%B:@vϩ'nݔ_'i$ MmT՚}G[{ EV~Yt{\U?^AOtյc^{\?w4ۧ9L%ek2Ԟ۴|@&2\mh-+X?<-.yBpRuUڄ#'֬ްFW];3=#I:YTg+79\?q uuZ]u]ݧ)L)fV5U}7E_#zt\ƃ7Bw~o >:)Y]ScÆ}5ʓ_9Y(I5.G.<:EHGt5+xe>uƌQ5tյO[|#}xn+N\(U{g5owBR@9\[v8pJ*uwmK}9O$$ʱ4pY4 d~￤䤠c3zWYt- ۧo>$@biJQXT Pw)K/0Sʌ/},{=u[72mƜw d;Zbg%mlbnXϫo=0&SgHGW7N: gH`%!m'v9aԤyp'KIMѪkWah{tl}6cWO҅R48P+K2iAt=wNU:&eP@&S&equmi8utߐ]G.s-MR9,4oĢSiAK8gsw xtE鿟ĉ2p }P⦼ S<[5'<~}3GOq&z"Q̫G|Й.[\O N&8cæv&: fFDŕHAމ<ѩenJr"#"Šcg~ $ԱǠK Hv  "#ŠN^ͭ #)J 0M=yph ȕs\7У SXN E_"# kh_ 3e.FM/ױsd2҅4 tŭuqz=8?MXD*bt2-(f⥇GdصY(w3maox4qgFk׶-4N=O{gS&dF?L!ajS#,J +۸G=7^޿) Tg]q?87ehB'<~4sp)j7S)?ӝ6t0%8_C!Ÿw+c#FHz'>=[zZ* }_gK7CQħ|CQب)yJ|CKW r+(%SlHvޮ7X 'ॅ&Xw1e$'SXn1@׫U+Sfi5lYJ_ЩiCSPT;05r4{#η6MuY4qһbpe|zV|Gim+\ J. OFS7\M71V.2BөyM&Rl- icrjU o\l#{ss4pn NeXnu{X-Z7 bMG\/#|RsjSx˶Qc~#6ՌJ\!|*xۍ6ݿ<_}.;x@ /+xG+ R t)r'Wr1?#574ӥU;9 #5%KNs#Ss ~BnfJBnS{/ }: }"xu8qGXZaj3 8ߗuV\9(N #*N\B=enCqAHq|p#8Fh1|b=$#Rd8WL0B4e$t"8#/]UXGGRV\1jTT[Dq-l>Gʹq+S UGq ]rF2צ%#c*RA߅ƃkY@q-l>G䪆S[#8F\}xU\ʉ8o^Q8 Ql8#8<5ZN#8#+s(CqG) Ep?#㠅'jjpX8(^@?#qۊ71Pa#@2?#qŨQ@=q0q6\=B 4 qGqY #~]U*, 8ߛW ~Gw#DBBBBB-!f # 6'j\cCXGrm"Oո2*!8#/Ή'0C t/!!8?N+ S  ɴXF~GZGqGW{#8\m(YfGqq`8VTF!8#/FS * Aq/GqĿ r9^&"!!@aHH?E4?RMdP)L DWaӥRX"FVtAm D!*Z)ÀEJ(qXtvBtjAK;qGq +1-gA}8E=G/qCR#8eX, C\5J?אPvDWqq%W<#,_x1Af#!i UbxUR!.iGBB0 Tk(8:n*! G3#6Q4R\ˍ8 ^r8ax\9jlVz}Z[ /鵫_aģOwNsi;f Ii(+L {f[/_+7o'( qT~܌WGsr8vbPL vCMkim%^[:?&ڳhu˽<-ʭ 콼S6o_yny ｗ^9߭kV M͟S.>ļێ6w#I|rj ~YqsG ~~._3a,e.ceWͻUw+6SoZsɹAJ~ayaIcW +/M vm1x|x[vGC&}X5!ݛҾ~)ZnK !ɭ¢%4M TE:f]5_5ݕC,sd~<__\R\RqrTA&Ks+MZ.]P/<׮Hʫ~DF$Gf~:D+t^q*82:*:};? QY]MݑZ?2aQBtLfC/NGtPicF?yЯ~~]sboխ/e%5ߔ_!v'kw21K|xџsOq_>8 :O;k nA.ю~V_vt_nK~}3K|~gU~ bVN&) o4U"o]w/V{/Pԓ(MG{2yUҘ[']tI#CVQ) E ^_G߹ǩ'=ss]lLtq`1O?Ұ-ˤSd,[ ___TXėjk\-?%D 9^p,ݹ {~%8]I'\^i\@`6O-@-Sg.}kǜ\Bm5i["WDUG]zxg7߾?hbIgKp\O>~bd1eq ; p\KJǠ8˚ WN5,?qxT"(~vj ]Y8| -yA{uMtg/N2jK.^4Ȋ1rfaǭ I+q)T!yÉV[t%v9+̏|r೟0 `ܜ!YM7eҔ₣Su1Weq69+trn'_ MRMZ|e(p}P(\1ѱ ww'pYq*ǫC B6OEg 1qT73ضҒQ^rY^a8uH&WcO> 6%cGrpew~q`~Ͻ/Q+r~fl岄wfV{)vzq ǣߘ; P)T:E`*b3 R~ JTſ{-ۇLZ(c3YgXrR94DoS [ _vb3YLI~}'H"Ν͐޽uSS;8hjl6EC_9Gqr(:Eb dL*@lrsIJX4@&|slV r%l&`biRq^7Y8HcґbO2<IΝ_L{^U>aҩq- Й,677 :F]n] Pyo[ +Iz&4to;y \_rAd/-qxf ttݚc?U,N|<_ӛ&MV$~z"1g&*h󰵧f0 YϣcS 1FZIFN άru.(^BNe,=Ӗ6!HQԋqI9t@ is2s"ٶFcЧý/+24le6=8k#be;{rē<3tiWtkgAo?Gc c2QQn]fns{6)ݵWS'/1PᢒV,yQ`ٖ164I";pk(ԲW RRӚLd`ڢSK[")IYQW?B$8yȎ/YPP_^v-0iY!v'Fە5 O/)b Ɉi[;@.1uL*=s87FFt;$ǧgbJб:pccE5SV,c.R\rtv@='+&M$,Ώ⿬Ľk@˛77r9;ubyikNiĐYa?F4s:͹r.g9x5q2*=~]gO:@AVK5nLinԛ***dRrt)τMY^,77fVJ:Iʶw>~c6{/?aŗJM2b`fC\Bf`>aV7O&z˟C[o͹Dxr3E3iҼ缸xs"%/o]-hަrP>P S~Qk\.Q[U(GK*PmyvL=|72p\ /Qt,,ݯ|uk7ԩyLH***[\&l-ꪥoБTNwP Zܿ#[֌k@ђD,IiMu\4C ˔'YL&Ey$'~:N޹]oi1i?{T XS43ҩd*y јӻ=5k:W<'\*4n(L-o5nß]/ zohˁ^^&T=4oފwjgg4 ,oL3vi:}ՎeVzд L*.Tuq |oL/%g@o%1s-u8Ťޤyd_XО{hPF%Cc7Y4D$=;Z-o_~OǕ $72)|˖Yy18zn༽NVMziҫY}ޥn]kOwЇhLh7A P P0`D&Uѡ3e!yӷwV/ϣfC[2NS: Eu.uө$\qBյ9f֫6z`nk D<1f/JʬdUvj>r{~_6s7ԛ_4R'\8 7xYnڨa#d.W/oLPcXX7/g$͈-,s˂:ƾtթBa %[j>z,\]wɐ:^q}͍]ؽxÈ&P}pMkYcbwYr2-{綹͗·gE۶2maf(KqHWCqR-.-;lʞל`ff{4\{*druaӥfYylylNi:}[:b?{]ѕnગw!_r|ÞY@;w~=~u!Ҽ+dkϦCųf@֍5~>;vF&G+g|5\9 }С+eMY``ѿy6.M>yu .{;R@>MlܛhgϘ,t7?,$qUCޞ'N ,\ NqjN-t;b=G{F}]=W5ZIe,)fq84-KehXY}& H?9^㺍۷lVq2jթ]/oi5aϚg`zq`F&yաgVl0zВEyWa_<<]>]#{ AS-kڮ+e}{76;9n{mΘwo+R=ZrՁ{{ҔWgo2C<`mF`(m[z.G>ZR9/JO|e> 8._o1Wuzt+ jIc`!m}긯qǥn:5i0qch7S0J3]DNZOܷG^wZp{g "~Q: .>ج~hƭƭn<kĂey@C{gR(8]tSS6Pc_S<u >;D1t:iIo66vkb~ ,oذxQl϶ٰh^mЮ`7 "l!e3lϹsjQ._U]Lċ#6egl𿶁XϚ{9K.<%_xNTKq, 90vc8.#{;[5]FO wpv8= ݊V)Zffgg>9$RDŽbiW!Tؘo#19@5rtCtL S#El=KOb0-&./QgH``htk~ֻ6vj{n?IR>Jd86MӱkX5/'s\Xu[ҔC BॽtS'C3:E"10 ]<%"KOɥ6vQt "?JwmP߀ %Ku=lXUVF *&D aY6qP "b6nu^j)>[AV.lwGIvdR{(LR Tmtb3]rҜb`X8)HYTBW,cb< )7ctP A.FMeRM )IJ_B>ű"#G{KKwWAL\WC#HCu?´b(ZP4+׆H?MmNޱʥruaV.qX46#U"ss˜yu̼\tؘ"ScgsXU~u\ _JyF&JON]@PR !$:H˜beCEb:Y)V4%2pkb_8 B\'3/l?טr~1gzFv>$~hFEqGK9,?W+}IqGqmh@8k?>h !!}iHMxHFWHHHHH5CBBBvd*$},ưb"NZ^>W9}"/iX橽vEIIן  zpc. вAw[:ߐ?ڴcD_\˳1^V?fTO-Xy<ccWo\CWK|'^~S"vU_/ߒݶoY`k̨N|ҁݥincr#xl *š^#kʵ*OYaMAyj?߆?7r9d#6'jzsmyMZĵ!/Nnzx LckRkRq x9X64񰡁a[P5M,'f<'1ql N5m$ڤ%%YB ;d<ЧǟwM#)V~䛧KO|?WF+oۨiqGi=$O>ȱwMq. h4=ϡ= 'r3/uK5p٢nN콕Q@}iҋ{ پ!`o{Dr1х1t}`Se}| ^ҿ˶;u/kE=UIv.: ܻn[fS4e~4A'DŽS@fإÐWHQM8/@p<#'bV]o@"x~~enM/*`߶{cj_rvI b,16vPܔУ;_}&?wfvmka νwb׾ U_,p(9u ~īëB=~+K[8\~̃{w姆 KrZn}qނC"KbDP$Hr S"߾xo_͈yE@9ODgup4BO %޺'[ O *Z," D91;Zp_ +ys PKNf(;"L0~lH(qY?Q"D(Hq\. DBD] DBA'F<& @Vl[sPtsݝ_d闔U_޲iP faBK3c5BH$RO:ycP =y.2jo1Cյ}W&w7ma;71 f}\:vY=|/l^pn8snl ͵C[9[|SNdz6}}9;Vw5֮^OU[vmƄ 0p;zw}zy 'tNW#nʫ&nI`71sGNxN+6R@rdʐW&v2hosbg#A"Mܱ~rq{׼%YOpa]3G#>o5iI;?u;90@h߰ygogY-8>OvoEEhfZ'EC0a8 ˺ʣFmϼz%n-?/3_ƜF#RZyA/d+1oٿqA>m}Tfu}fRy']K}CL_S#\ d[5ρy1ؕ%$60p=Z1ȥM[;EH K$}b,71*>)6Škpq^zTbwL:wݼ)]2*ʹZ~V+qr/)Gϲi֙tl712nzåX 8qeF8RX\Bqvdٻ b)^c`0+=NR>q=bz:97zaG%7%_)禍n ѹ?= ~58 Sі0*ғ>},/N{/d-^.Xױo h]g QlE%z:z7sbT}@&~2WFZSdc(L(J$ScU3Gr%W+42ejK9qD \..>woW*Pu}'EYmJLݹqbc;#呖mR1?89c{kz;e q 3T&æ(5tq58k3ԓ']FO1rLF7vt3W~ٽ>XxQ\mdR 9* b:15}e cv)0#xYYWڴqE|Nz,zxt [x%,0-o妧 U~KV]C^ށ F=թܼ(2>kK)/?}PAJYIT;wSes" )nȝf-۵Bخ%ctlh3uVuJ)O_qҵG5'k%>|(p( ;I'Mӆv0ba@6UY;gQn'=#ARVzP 2?hR8Ur-ػ\82cn)KXҎ}ZMp0`( /LY>V,c+۸/֥Put 9ۙXYHl~f'֯>,$ o@_٥[ kǖ$ذv64S3l9y+d[mO2~۪z5,p%6Iwhg W0eխcmQb߱j.Vt 7%!:1|gҊHn`bMyy]_CC+gK/o բ.p_/钥/.Rغ.ԡ sh,&B-_I q5r.$|6Ӓ|9\aE1MG8V.͌r)&u]}|ݏh:׏4+a˗{CK;҃s׬^hlo6$Zw.;Oxdagn}_5yù6'Jl˭J'L+98|W= {(yvkޝΙ[ Cv~7lz'zИQI[ L|' }">`ܣ˄Ntֱgs &V3v~t\N4woi4nyoa5Bh1f>m 7>kAᚥKk Ffd댾mplܮACGGGp⭛tgv֙4!`P^j@G{#xU\?bW/N4kϖ͛z~8qV ,62L~m^eEbنu[Y{Fq4Œy5uhc,x6Y64 \$`ݶWHXԐ#~īH,-V= /ӻ,`X8z8ٚ@T$q5(pY~jtT\&_ȮbYHzćLQy1S@B1"Ƨ @V˕W=7nk8ݒ!m4Pӛ )x1D Y4 >%IQ{B ȱ3+;"ةa##\#3/pCC 9efj/ /nΦ55äQ)łmDr")_ :DiP,ܜmTT"HIxqџRsخMX*j(%S\XfɑaTkE}au9|6nCH6}~qwdslB:B //iJzh1&le޸ G5޻Mat،4]m(Z!~+שSݟ K6Xn]nC ,#vMCv[G#*GH47)abin\nv5ӑ  td:/'UrSCP$U#gfId:IB<qM]$:DbI!WD'1'UrSCP$ $ՌGâʮџpgpш$WpL Y~U]x\ѱ9qsL Y~G ^5(8pD Mdx06}"^+L H6jpmdx\[U%Oī֑'⥼zaB"D8qS1up3C_C]DAgZ.2?Vի%olZ`?ϣ$r:ÚLd9zK/,?7C1у'l)8G!2']CO zyF爾`Ek]{P E=N-&C/:\GqRqCt9OwVHGMKI3&zL(/3m;O?>q8;) KTw/}1q #,GdR^׾!;~|hl8iݰVtz9M;јtv둳/pIA'mv4r$];%٭lM@~Oda|k[)գ6v<4sl2nd/\ݜ\8WL;Lݔ|x_楾]4ogefdefĿ0OCRIQ^V_"3J$Pzۈ4 ??3D*ggdJЇ7+<###+3ꡇ?]$8#+3#+=#Ź9\--,ʁ鍧,H K{}rZVfFVM;L/O EwvY/LOyynySye'#[ ^˹q]8`8"4~8^in8ZN>>ڻn8Xaެiepbom>ۑm7/ AcfzLh`ТYχnԲ Z.n43G$m'nX= ˏܼlˇ_uEWo2tQ6]3ZN L-}6:dʁNdpcR쿘- ~eݼﰎ xv#z;zW"yn؉NC߁c}-10v۫Waݺv֭Ǫc d|~UF<~">>001j'#;)#G1ƺ  Bg{|9ʫrT) ^N2e80k&CǏH=;IE"6M|R,$)hIH\SbnbsssssVdn chbYژRr)@NhtzٷIR^plK?Wɉ)ԦR.8x-@2?׌Nej©w⁷ϨJ22b"XCE})MS#e 蚙EE~񯟥Lo>qc'^9%@*$SG)dUǛ1(a}|['AyUʉQAJN!nSQc$x8`.5Pڮ`0L/]U/;O5šٛO=91wR ZG gn*(,!1 EKW`y-n>q>26..Q=NG1 Mge$~xyuC <T%/8MttLJfX4~NAĦEDž9u-JkE>@9*R$xxrArA8T#83ZNAx.|}|}Fyu)Zic퇹jپc2 e~KSz/]|ض}|;}W|NMh{ZSq4~.=7vi;~T^izC.ahlO;t5o>U=ܽ%K{9x5x/#"Uz%m_/+qj :aa9n4sfHR>4F]>zjIߊħUsFqأwr+7Ow+ ">&=0@)Zذ/ھ -<,4_cOk/LԱiWO5va/) {iZ džGgJ Y?Zc$~ /#\P,-,`@t`a8(#NfäSAԐ-x1I ^cau9|>I ^N)cpΉs0RA īĀgP;b0Iϱ/GqĿ;qx8y5@2?WsUr 14B89q$k1"I ^cI ^Nr q=$׬sҦ ~9GX 9 (:5) qrsdx :4~1'8I ^NWPby'7WT9A0"I ^SHp#Jqp '5Lj'i ^cJ5k#P-  0EQb8qE@yGO?טIsq'īiP+ˎ,~:N Af\nUs8(bzC\$~ 588N?WS8`RY8ٹk4~1G qd~SE)eEUgPA\AIrE$ī)/8`#N~Nx9`@*?ה8 ^0e4Uqr}J+=BDJnj#Ij#$Oī]M.(!ī)c*ŭ=w89@*?הxM9>$~Z[p@t 9 ^38Ur ajB'?/-`rAfS ĿcF*?Wb(RPI%JqrŽTk'~1'J?W0PUSNj5ĂZQ'Uq 0 Sxu8 m pUⵂ+(HqpA$~Q(HPT*F`6gAZaFQPQ(aMryCZ%# / T0 0 QY&x%⸔Lp/q2r }69)$~1t2-(fHs3#+3lA:J<P>tB\!,~:N%y ^rqT!?UsGb/qRsBĿKx0pŨQ Sje@t\L?RA(G/2A:B,8Nbqs kK'9 ^cʱ6r;B1Lُ %$ 8I ^s,JAk9N2?WK8F889!AΉ58:&N# 0 #]?{d/ {% j]ZG:=V,VNܸs$T>9<;rs/@.n LOl.Y! kzp&w@?LwP`]9@ C;6_O4d zph3.謻!b zx9.yaL?D&B@ez[o7U6T 3K3c:rEFaz[.neߍ'7ث&Fbٖ4JT֖L?QcY_ŠB/vOǧTZLsdM<.Dz >E8TiBT[WQ,,8T҂A!j QCCbiKܽ"Y+yGiF6{RXSYr̍_Wjj$ č5 0fh_)*VhlShZR_]$-̈8C'4_`=WէyOv+_M1u\R[X2m^[W?p{{(5aդQ>rzQ#G}ө'h>?ndʔj =3]Į?pac-q - vM8}5*ER-7\>ggK-^gާsמrmGr)^P|{/cj[K0{籕7ۿQ3\}^ޔsΘc6J(u\!y٣&L~Xo/ʸ|t皾1- ⿥]kh0{Ӕ1WQ-qc͓ 5NGx+En~>a7 {=}o'm;ÿv+?`{ۭxo& H{R ̽p"m/|gtр6SJ|藕>D;|.޳m[?mJg/aw9ocyK>,|7 9׎[ ^8йcXsу[bJ '.tQ{04/guu~dMXݹw#+G LP B󼚱G\F,dF5KIf?{S<]X2'3\cs𾣔6՟02!ݱ7Nv@Ɣ˖'%.r^ݹċfx.Yl`~QL}sy2gsE1^>Ԃf BH&,%Lر~I_fՆL`guIXi]>t2 :v/Fi()yvf+*9?,g5ӣhĿ&{ G a[Eh_ܸ[*?| (*a՝;wU"KK%}fL{}fC-D$߻tfk/yr0}qw/gEKsDB&aG[yR"%=Iq=b:kQ2 <:bd\-_۲} RhyK}lg7n?Gݚ Zq<:q 7Ε5W-xr68 Վ]ݶtˑj._^28 N1 2)C%ۡƓB}y3k R|zρÍN%%J:N/d*M^S.^aEĹ> eU^p*)X8O82 !_IH8u}LEk7DyWر~ȴ NڮdUk /]=s4v~yz"4j ?}]uo/?R8}TҒ1'v'i&=Zp*)ᷕ&7ݕUcC= ޳O9<5BXSʍ;MfCɿ]WO8pG;5J%u N%m?*/nr4"'ܶ^(nٺvzl6st&nKsSi^vYeR(K-|[:8֓B'PM7Ϝ?GGRܮu*Հ?cQe~櫈bQ7վWA?ᣙQ'0zJ\]_UnL#_2~Ԁq#|Ŭ5"JQHr̷{|Rž a̲dԨJ^q}žSI ;{ ff:auOq󡤄SIC\͓o*gGvkdY\©_Wd7am©ˇ%G?9֍V.xt.x@ :Hг+反4cKPgo|=$ sWm&NJ6s.%93i{.=m0$U7R Ф[] Y=P~ ν~iB~f?yw/׾}Q!@b|ug(bܚj[tҾV9C?rbց \b=EO.;; VOgmD7ߕOj싞$ȣw%ڔ};NXY20ЄzF{?zjnSf\< qrvW/[+]>e(*!Ѹ%f!\~w㋻OJ5ʨZ&Z:سdڈ@P:Σ@b;{8DJ!B>xۿ0s5~ LV_z\1Oggr܏ϯw`bDxlczsLsw7mWw`ݶW ktpbiQfaC S` H _mMDRӺVy1'^6ߦN2J"Q4_\HFdZ;KxERR>q W;:wG{4\( s-씸qm-+@|ɿ⮧VVX6d 0ζ C+zX>_^#3Wo11 'gtѫ b|Ës̷ەGs'x`⚇rfWN!~ڹ|7#GSMh{Mss^=|{,{r|Zq;Q2@ɵ=Si,fc*ˌמ+yTO7vt4J X5dD?/J*~xU <.)SfjXh/jNyl>B@ڃZZPpC%)չׯʊ@ 5ԕܮQF$CdsO55PIWOs@7"rN| *D] Dgn_alCڇ]@h6!SOl7G^P*j~+6~~RJEj"D$ۄ-xr>v63jb @ o3Ip$#c㖲{69so,_pe4i^ŦO0uՓQw#tr =}TG66fPdf\?M"Z{<"m7J ~LqA@+_o;GUvb Xܭg{ZJݹ.L_o+B|H#>(},Mc WmCxZ*B0oǗ[J)-}\~WqjaPqI;q#WE3dN&i4rU"^ѓaR*R$I!noMш=8  RJz&zC_4S/K?sx{w`Apy|GVan*H/xűx~eAe"(D"Q8jWWѨty#IPaa)W$Ssk6 _ҏVAn^מ$@pTh{`4ToI+S/&cHwȣ>k+`“={gC%4O&u~^-8Yys[ARQX|w3"{8.o;/Ts=n~i& 6;q~q΂rqʢҠp; ';WfҮyՉ|w#[dP4=o4nW va>n kO1Tzwal¡Vmzf  ʭ5+2-^#_Wz=t[w#/N5雾Tp̖AIKytw|k_ s"0 h=[ަ{~cr^[Bv}eosLWV͈X1w/req7եEߦǾKf|}plmÆ;G~;c$1O I _7e|RS؄_<'%,iݜp/cjY?T?tfdM9y.Z GC-2p&]%Z9ى4;]1 w}׏Չ,ט飼-)s%|4W?9~%|[FR^$$2[+#J|MǂAF[yǙ!Q̞:ƔH/g{B! -Nɕ"hDLAb+\725hn;{~S`t4QA}I#Oݸ~eSiLr7ܳo!ݪWtO9'E.6t&TmX0Iui=RS!1`RI59 L:hќg%\Dd _ph"3d"ē^RULG1ebAy=l!MeRwD3 !c%!d0 \&j@ouI~P͔,$F=|@%,/ey{ZR󫊛).=ƒ6= ;K,0!DK-R$Ǥ {(C(_u%lM*S Ŋ7ٿVwߞNĒ \29Vl? _ZQTE3Ts׏#LRW ~Ȁ^k= '6e5ݻ a$[KؼG7c*?_?;q >)|AVZ{׆Bjam c1a~8nؽϜf y:d qEoW7WfqDc)!L0iD={EuN.+*ӁGғV̴@ r4!)n,kI"Nݾ~c2]n9cj=m/z u2<﷉JY^S/W.iP"d &Ly<m8&Օg,Iaa9'o)AJ*5 0%T 05;of;җ+Kcxٰ tKʘJ&5.inKkw[lFF^ig >TCcH7 ׸$=;7T2*d(7K"2(;[堙Q Fod]Kżu_$<~Ȇ `l0Uw:`8zx& 6N4/ViI00=ĵa0N &çoir1(/\3, GO_n AO9Ȁ-+x}`h#^-xpdٸ~5F\y A;moCvҏ>q #iWl{{qګZR$H;S˸\3t;休T(oG-(~&SY=*yK'U)WgVM:^X)O?ƁWyrObnʕT^ޛI߅knAڽ?mM\"(ORIbE?gHl\pI%}}+>vCqiq?Q1a{%$)~h>2.^siN0kJխ5tF{ac#wkR˩V)I{óJCRRuLjKxqrP.c}ݤH*@]ûW5;mfNml:sOR9i?7H]\ko f"0kn@+Key7X[KIK^ q-YgKS*NG=h }ܪ iRJPV74;{'#2NS\TYR"Pl)Ԋƪ._ tKog[")xyb[G7 NSP_!8ّfx&]0YTsw';* %&.6dP/K#ZTRZNa%u@1qtq4#6Б}sevΚL`j"O0MJZRU\(pKFT< s|ş -5 B̬mtظ2if ~Ҏt@PWP\gZY2je*iI3 yۛKx3&jzx0KKMm̵SJk5bi⠖+K9ccxKhoƣ{[viR1舾[W*G*Jj+m}$WBUaf:C!ʿנ!LuԆiْ GVW(<ՕDX]ܼGyQ ?6Xl`%Q>L\P\.+ ⺬[5EIqp27"j+xyمR@xS[{sjk?1lM%urYv ok* _uw@0m[/bKs?/7ۻ׈oLyޚtzjnib?H 0^|K37ރBaXu_TtcWωu)ם˔`:U090>aWNHYGu__x6ّm@~}t((}eΓ6-" И?Ł'$"h~qa傭1OP%X%>ǯ۶6ĒsMAoϺvu- Am3f>޸㛠G~5y vlϬi u>3vmA^0$ZaKP}sG+ Yd* 0B>YjDk:!V]d@X f\xT8GV4%I+`wC7V ['cʎ:) xJen1A%|P˛nϺسϠ!)/i5>?%Όyyo+ve'jxc/>_ݯ0Y]#dfG?4S7 B;o&gK6d3=ɇe+h@!L-UI" ð+?5LwOuɽs5E\>6څrVm'> PM{eMewY^Kf?ťSE6wqYDݺX , :_ d`gmC-bA.\w9"@m=q`𪄸ĸL*lwÆ?)=~4EHbZ‰!2ʯ;?/1.>1m=/^.e|c3F[,'-2.kzyQr7;ZM9oͭ<>m@:+-]BX3yAc~~9 %>1.Բ78C%ɵ@M4 ܬbsr^wO-'1.>qzuIT?>6vl8ȶqjW.$=i/BAm_7ju\|b\|DvΎ=j$N+E@]N8-;_@]vOaR|wm nj)5€ J?yʭ)yk*gĸɽZm~&!'q,Oyr!Oew'gO*T(ɉ}?|^:ߖG14̺ ݺ$S1.>Om:yY7VI.>1.!i~:l՚m#-#'.{$qlZ%E8{v}5/Onj< .uYO?>7@ KE>૟!Eژ]#0M{_\ٴOR@P~LZE;l`[A[6'>1.>q_ޒpU$޽W~c,݉{P~ _uwbmHZJR<ω]1}F\p Zr݄Dd;zYRq~42hL ˢׯ'zK ܦf"EV*퉙gO?-8"v_Ɣ~lK -Fm`k2s*UDC\S, ϓA;(s.-L6*٭8+QT$'?h@ʼ%M ^󧷍HP%jKglotlo磾|.Yw&98ٺݷQ O>S"sbHIq^i%ƴrs@@Q(|QT))xr48)G"rQ/bo~hԥ|G$UJ OAq zʊp:1њ8u u0.0x> "[X?s[a2qMdRyX/>&Ń&@ǯ"An*MM^nc3rvʸ!C[*"MT z`a,P𲞲E1..#,,JsȩƱO^:󳑁~Vgr}|Ly FMx/TYWT+V+Dt;jDH& _uwjLk44\o5RۛꌀAa4r+:{=?`st<wSsɦj|3{u;h\ٍͥ%^u@&@"hQ%o:U@paqŴ<9>k?}ʄ݁ CFu=d<(d|ήEc$bDԒ頃~f>'NZwߊ4v@ڍĂfYyFۜ1$b/3Vyĭ6 .K?Wƛs0l/AdZX[Q*<|xMaqj5ncFըSc?y{qw9EsFDp8RJJB~Jm>ho`9tfFU\:.Ơ'wS@]ug4 +~jDR0l}F[е@g8^Q]~0ڄ*zA?#MS*q,^6na2՘MA`⧸#077JۭH|iYO=2v6m{ز/6Mݍ{K>׎8]^^o74uiipEdE] dYsf|jAQ<لe/Б.~=w'Ksiom?vp<g6~۷9' Tј+a!Y5>|'2۟ɾO Op]>hdj 89)Sf$czp DJ^7[e}5o;w6m1r0yƵ1 0 >Y[bԂ䉂F9a*Qà |WEp]g󣷢[/qs0S_ >(2g?e1fYV{[;tg9Fu5nDY]T{wG0ޖcϱc6礷0E`pX˭{Ҟ0]LY,}_|- ä)KZ𶜀OV`",r>~cG-᫹VS#1}-jJS {9*'_& 9utzrFw/#[pO;G b@K] \^W7bJ;18aMD6.M+J G$^-WO P D^raܒITLg_ڂ'Or1 Yk%¶F6{tiGm~<-J^:ߞG1nѫ򎝻Yh702mUϟv5^PQ(a$'<:3bf8rX‚4@JJy*e=տ%niI+UX8rm9L#2,9=V,څ͚_*df :wc nICrRg¢spܼLH~hE`4־mc0W޵|r JyQ4MtVr <-%[Ҝ5^߽:%҄2aU6e-[+)=t VO#ۮ4#JސLqS+kPB'2[:ђ.- *ZOL_[=(xJ9ŁwtOt1anDewc`@vGgFЛ$lǺTKں2՚\֐}lG <{Ǭ~dT 3 D+gs=k2OYuz:_f5O8Ԓg o(gϲ`K#$8r`bDڒڳhm]/?@3۾1nnػxV1`j\_ח.;[nU7_xI3OҷCTnCc[>Jd +&$ RR^Pn٭^G*WZLiǁ(&4ڝ& On9=8POB@2\&U&OLq7c5h]RZP 2o6ljCff#Gx#@«,+Qv0!2{ߑ֨EQ\&.9C4ciM}GCLH *g/!cmzJ)E.}GD^|:?ϙFd"m՞le;1L!@HTVUXDvŭȭe2<Άu~x gbmV&"66"A"2bb{G2)W7e2[xf_>v"{ȔL_SʅM2h:q垑!8isjn\fط)ˣWoRL5a u\uPt/6Qٮ{5rrNk~d5{Z 29e𬙟tKyghRR(^RYw u`diI*":}h],ww_(-h,Qw/H7dngeL%Kw{Қl(-@tw#Ĵhf !;[+GG Pt6]p9hj(zxgy[* CO4]twj1Adr7L]Fj ^* AO_o AO}6-t=xB4``X7tڷD'vH) IK9rZoHEv\]~cϱOD%&) r0 F, +0 #zDf Bөxz Q3_ak_% ʠ(8D*^~.qb@} Hg0iW1T(ȁabBĽ;׫Vy|50v᭫ DO+\mC]eҡ4[!2f1{2A*Ee' /ү_d֋7擯<ɓ(^_Pqh<}9mލo0a]=3 |gJ= ^E{ X ɗU TcL18ܮcb47qer+3'˔Y ngt WMxw3e4mm5,nYeI'R ӯpe7^q hܒY\`lO!i|dgnQMF0v kkg:N~\)f8 w-w-˚'``Ҽu {8&m `V6חURU=JnyAXxlƢRCLWFBjzRVn//) :ecQүeL!jeJXK/jjϜVC8ݜ{1  FVXRi[S)uq'2_X\bVȸzP­qs! 9 !^KO^TҮ:s_'mZ:-k?h 7f؁t**7jo2v_2bƔw46㉝_Ξp^]׿sΥol~ܶbUTB7qѯk9 JyD_ 9%6(8N%JZFXZoI~!zԏ\ӫsAcQ]xцkt6A\y]zCdB=CŠyGbs+ WسKR Z#*|cnm2Eع}ܡ-ܬw~=oL1/@⠩NzϞgys2-6ƿ;vxrZ) O$=hro8<h3<%  Sj8w3¼8)[C+*=7 7BH'?_Yav{Woo[xVfnem\ڗKtNUnZTo²6UY;.ݸꫮz~\Jꑿs]qłFo*s̚ ^$pv~Cꐬt"_sϙPsiaAz3O29eI1`-/D<~mz~7ܷ7~cΐԆտT}J?8qP~Sㅬ=6>VI~LH_ ;MH}bޏݱ(U;孽<>>mۿNԬD5JՅ?Ί6*v.>1qxT4=0r~in#MkÓx{-\!G|_ioe-|[ L'BxvybqC#l/9-}9Syιե=k6]]r [Rc/ 8%8_өͫdžNB=WRZH=Q*@qJ ܅׬Kϳr{_{5, ӣvP]|tIտsLd gTNqBY.'&U^p͙GPm |Uɝ6_46g9c VZ2~gL] 'mXʴ)f:%vL\Go?`k~/ |z¼q&SꦅxZx|#BU9`.7H{c>|mقSSN(7O=jk!ATsUl޺nŚ]|;FTqaq.FȷhB*ΒKaS<%gYYjaܛg|!8Թ:Oh-lJyяDa)3+LG z->y3Ǐ q/N?zϮK2N^u ?x|]W#zeK*ҳrL}9oYޭC!Jtp{NTL[NP{5/xqQC7;|SEPTR!;_m䍷}=erݽOHx!:˹<՜-Zmu͔6[˝D"zo {1p- !D0.uoj_kPTHi06JyJiZ Rwp&+}-C @^P 6D~<20֗ʈ0O}n/ ;?&MIw+~dԡSsʷExRyԧڅ*Pk);z`wQqm7 %yr5vZA(UV]mG0-`=^g JRj0/.!R8nuwjP}z(>TᮄPg&?ufJLͩ,EN2 B~d\9d5M蘬iKd +Z%3/OzΘ KvzCF Q2 B'">6X)#eJC@]6^OH9|yTF4@]asvZKk[aQ?kxu-{4sVWL5qpZU% iT[)/?t@eCAO~&`uOVڽgڨ|b=^儣kI-_g$n~eND&zb̡ 9ۃBRO/suEFV.縸^eDF2h;`Z6,*ҮTp'vϴi: {o#EzIsJ080[/P,S&O%# zJq6ң}ô__'9a̐eHȞlɩ+& )I]E?8^ҿz$bmakR"p[8w2aq[pBoHDr7B*L7'ƥHJnJ)amgxSnlfG)a{6PwF(=n.3 endstream endobj 76 0 obj << /Type /Annot /Subtype /Link /A 77 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 177.0863 260.2500 312.0863 ] >> endobj 77 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig1.jpg) >> endobj 78 0 obj << /Type /Page /Parent 3 0 R /Annots [ 80 0 R 83 0 R 88 0 R 90 0 R 94 0 R 96 0 R ] /Contents 79 0 R >> endobj 79 0 obj << /Length 7951 >> stream 0.271 0.267 0.267 rg q 15.000 23.833 577.500 753.167 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(DuchenneConnect is the largest US-based registry of Duchenne/Becker muscular dystrophy. As of June 2011, the registry )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(represents 1,595 patients with muscular dystrophy, 98 carrier or at-risk females and more than 300 professionals with an )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(interest in muscular dystrophy \(see Figure 2\). Of all patient participants, 69% \(n= 1213\) have submitted a health history survey. )] TJ ET BT 26.250 731.762 Td /F1 9.8 Tf [(Eighty six percent \(n=1366\) of patient participants report having genetic testing, of which 47% \(n= 647\) have submitted a copy )] TJ ET BT 26.250 719.857 Td /F1 9.8 Tf [(of their genetic test results. See Figure 3 for a description of participant characteristics.)] TJ ET 0.965 0.965 0.965 rg 26.250 509.821 555.000 200.155 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 709.976 m 581.250 709.976 l 581.250 709.226 l 26.250 709.226 l f 26.250 509.822 m 581.250 509.822 l 581.250 510.572 l 26.250 510.572 l f q 225.000 0 0 155.250 35.250 544.976 cm /I10 Do Q q 35.250 521.072 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 529.452 Td /F4 9.8 Tf [(Fig. 2: Annual total registrations by year Nov 2007 June 2011.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 298.417 555.000 203.905 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 502.322 m 581.250 502.322 l 581.250 501.572 l 26.250 501.572 l f 26.250 298.417 m 581.250 298.417 l 581.250 299.167 l 26.250 299.167 l f q 225.000 0 0 159.000 35.250 333.572 cm /I11 Do Q q 35.250 309.667 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 318.048 Td /F4 9.8 Tf [(Fig. 3: Diagnosis reported by registry participants.)] TJ ET Q BT 26.250 281.393 Td /F4 9.8 Tf [(Demographics)] TJ ET BT 26.250 261.988 Td /F1 9.8 Tf [(The mean age of participants with Duchenne is 15.0 years \(range 8mos-64y\) and for participants with Becker is 26.6 years )] TJ ET BT 26.250 250.083 Td /F1 9.8 Tf [(\(range 1.3y-69y\). See distribution data in Table 2.)] TJ ET q 450.000 0 0 153.750 26.250 86.452 cm /I13 Do Q BT 26.250 69.429 Td /F4 9.8 Tf [(Table 2. Summary of registry participants as of June 2011. Patients include those with Duchenne, Becker, and )] TJ ET BT 26.250 57.524 Td /F4 9.8 Tf [(Intermediate muscular dystrophy.)] TJ ET BT 26.250 38.119 Td /F1 9.8 Tf [(The majority of participants \(77%\) chose Caucasian as their racial background. Though Duchenne/Becker is presumed to be )] TJ ET Q q 15.000 23.833 577.500 753.167 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(DuchenneConnect is the largest US-based registry of Duchenne/Becker muscular dystrophy. As of June 2011, the registry )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(represents 1,595 patients with muscular dystrophy, 98 carrier or at-risk females and more than 300 professionals with an )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(interest in muscular dystrophy \(see Figure 2\). Of all patient participants, 69% \(n= 1213\) have submitted a health history survey. )] TJ ET BT 26.250 731.762 Td /F1 9.8 Tf [(Eighty six percent \(n=1366\) of patient participants report having genetic testing, of which 47% \(n= 647\) have submitted a copy )] TJ ET BT 26.250 719.857 Td /F1 9.8 Tf [(of their genetic test results. See Figure 3 for a description of participant characteristics.)] TJ ET 0.965 0.965 0.965 rg 26.250 509.821 555.000 200.155 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 709.976 m 581.250 709.976 l 581.250 709.226 l 26.250 709.226 l f 26.250 509.822 m 581.250 509.822 l 581.250 510.572 l 26.250 510.572 l f q 225.000 0 0 155.250 35.250 544.976 cm /I10 Do Q q 35.250 521.072 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 529.452 Td /F4 9.8 Tf [(Fig. 2: Annual total registrations by year Nov 2007 June 2011.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 298.417 555.000 203.905 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 502.322 m 581.250 502.322 l 581.250 501.572 l 26.250 501.572 l f 26.250 298.417 m 581.250 298.417 l 581.250 299.167 l 26.250 299.167 l f q 225.000 0 0 159.000 35.250 333.572 cm /I11 Do Q q 35.250 309.667 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 318.048 Td /F4 9.8 Tf [(Fig. 3: Diagnosis reported by registry participants.)] TJ ET Q BT 26.250 281.393 Td /F4 9.8 Tf [(Demographics)] TJ ET BT 26.250 261.988 Td /F1 9.8 Tf [(The mean age of participants with Duchenne is 15.0 years \(range 8mos-64y\) and for participants with Becker is 26.6 years )] TJ ET BT 26.250 250.083 Td /F1 9.8 Tf [(\(range 1.3y-69y\). See distribution data in Table 2.)] TJ ET q 450.000 0 0 153.750 26.250 86.452 cm /I15 Do Q BT 26.250 69.429 Td /F4 9.8 Tf [(Table 2. Summary of registry participants as of June 2011. Patients include those with Duchenne, Becker, and )] TJ ET BT 26.250 57.524 Td /F4 9.8 Tf [(Intermediate muscular dystrophy.)] TJ ET BT 26.250 38.119 Td /F1 9.8 Tf [(The majority of participants \(77%\) chose Caucasian as their racial background. Though Duchenne/Becker is presumed to be )] TJ ET Q q 15.000 23.833 577.500 753.167 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(DuchenneConnect is the largest US-based registry of Duchenne/Becker muscular dystrophy. As of June 2011, the registry )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(represents 1,595 patients with muscular dystrophy, 98 carrier or at-risk females and more than 300 professionals with an )] TJ ET BT 26.250 743.667 Td /F1 9.8 Tf [(interest in muscular dystrophy \(see Figure 2\). Of all patient participants, 69% \(n= 1213\) have submitted a health history survey. )] TJ ET BT 26.250 731.762 Td /F1 9.8 Tf [(Eighty six percent \(n=1366\) of patient participants report having genetic testing, of which 47% \(n= 647\) have submitted a copy )] TJ ET BT 26.250 719.857 Td /F1 9.8 Tf [(of their genetic test results. See Figure 3 for a description of participant characteristics.)] TJ ET 0.965 0.965 0.965 rg 26.250 509.821 555.000 200.155 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 709.976 m 581.250 709.976 l 581.250 709.226 l 26.250 709.226 l f 26.250 509.822 m 581.250 509.822 l 581.250 510.572 l 26.250 510.572 l f q 225.000 0 0 155.250 35.250 544.976 cm /I10 Do Q q 35.250 521.072 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 529.452 Td /F4 9.8 Tf [(Fig. 2: Annual total registrations by year Nov 2007 June 2011.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 298.417 555.000 203.905 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 502.322 m 581.250 502.322 l 581.250 501.572 l 26.250 501.572 l f 26.250 298.417 m 581.250 298.417 l 581.250 299.167 l 26.250 299.167 l f q 225.000 0 0 159.000 35.250 333.572 cm /I11 Do Q q 35.250 309.667 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 318.048 Td /F4 9.8 Tf [(Fig. 3: Diagnosis reported by registry participants.)] TJ ET Q BT 26.250 281.393 Td /F4 9.8 Tf [(Demographics)] TJ ET BT 26.250 261.988 Td /F1 9.8 Tf [(The mean age of participants with Duchenne is 15.0 years \(range 8mos-64y\) and for participants with Becker is 26.6 years )] TJ ET BT 26.250 250.083 Td /F1 9.8 Tf [(\(range 1.3y-69y\). See distribution data in Table 2.)] TJ ET q 450.000 0 0 153.750 26.250 86.452 cm /I17 Do Q BT 26.250 69.429 Td /F4 9.8 Tf [(Table 2. Summary of registry participants as of June 2011. Patients include those with Duchenne, Becker, and )] TJ ET BT 26.250 57.524 Td /F4 9.8 Tf [(Intermediate muscular dystrophy.)] TJ ET BT 26.250 38.119 Td /F1 9.8 Tf [(The majority of participants \(77%\) chose Caucasian as their racial background. Though Duchenne/Becker is presumed to be )] TJ ET Q q 225.000 0 0 155.250 35.250 544.976 cm /I10 Do Q q 225.000 0 0 159.000 35.250 333.572 cm /I11 Do Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(3)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Muscular Dystrophy)] TJ ET Q endstream endobj 80 0 obj << /Type /Annot /Subtype /Link /A 81 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 544.9762 260.2500 700.2262 ] >> endobj 81 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig2.jpg) >> endobj 82 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 207 /ColorSpace /DeviceRGB /Filter /DCTDecode /BitsPerComponent 8 /Length 15504>> stream JFIF;CREATOR: gd-jpeg v1.0 (using IJG JPEG v62), quality = 90 C     C   ," }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?R((Q@ (4PhEQE&p(hV PEPERwGjC@ IJ)(h%)@)-wRzRPhM;EQ@JJSIހ^MI|Zx_ iZnjRF4 %bN0UdbAmzɯ;I5Gxj;afKBM`T$ah;81!Ljg,oC r9<g- _ZƧ$nP[ w=xϠ-i-:]!_CKecv"e|K0f@~u ;VR-7i[UҮ-Mpqľ̊ 5&؟ ZM\A7ú>-ү-?\AW>vҌ7a@`I>05ezO^m-"o xe4V>K^vɲ,Gn4 ~,g-Bo x{E]/Rtϳz7\ aD;W`վ"~?xZ&dY? uC'pPT~qiGxnm;6%DE2l4fY@\Ɗr͎ ? t2?鏧oi/gnf3y{sN-]d滿 > NjYϪ\5<+7=*.c,N Fso~GM;B׮uZH4,QgB>i1*}/Śi >ķq66eFl2vF~fʕ:͇-5ӆ@C+N5ia٢ida.UUA\ܟv K-Deu%Hqm;`傮5ˮJu˥L짊T]MyD /?vwMj{l/b ]s3x7{+,noUV{iNAVX tasҸ:ƥ.awYp?غw-IC$wRdxVBuk?:vclkpNqҩߕrߴk?Xiiƛ zcC d݆M; cp[JPWg$YKRa(~PKd $@}Jm[‡KHѤpYIlG/ڄG_W$N?xDL&@>k7⾻x5)cm-!n;1 mV-\=Oݧ´ 偘=HSyع#,>ߊtiɨii{fFʲ `zƹDr <3hhtf]M4$kT12C6@.FN2t&_h5Ulh~̚U*Aӭ|sǾ.6Uu"5DtP ~Eڃ@ۏC*?ԇn# ,4a);+X|J9+rbA@Rvfo׊>x[Jt=~᧸$U݌*+ePݛ֫0u%=]_^W|At.KqX-vB81~c^4;?aԿݷNTj:rEV vfɣcaé߻o3G :5A;u/mh: :4KXw0_aé߻o3@V? :4w0_aԿݷw0_Gj˶nYYQ)R Z\Z (E(P(EH#uo}/QEzžk2=5W$Y]HۤXܬ#p+da/ij#|,stu/\q Odc5eC-'}f}~9blU112)>|ߐ) 傷[:|=KfтW#o)8|'OZҊBS6cx]6K$y#bJ0 fwoqdJ|Ieӥ~o;Ҕȓ8 y[@>=+Zރ]/\ 1'ĢM3Ó3hn;RcFN0 `u ʖG凍~7s~>!V zLPWokPh&*HD2BP: /?\ BLV?dozHh"iꛨ󚮜0]Q\?S$t?EzkۋI&?S׼yi2U-Z??[)ϔrOYKq:/ذKwaY\U}yJ&.g\Zr^2<1w^uYLK(nYV0 b\ڑ2鞕 |>zݚM̟]&"kzo/Y[sK-5k{YErM ʱ1> 6F5:ď@~O9~&jb FD#]J[f= Iu >O/'nܟJֿ9y?KSUŖ3\jvNsa^HeH#bC̞\,['x$Mokڽ~!ѕtkٕ'kbO?MIwKVd.z7pMY$qrI;\beJ?"jq%"Hq "^{=r̾_?E|q>)z/mǫOQZ"ͦ]X(! 1O,}|?~׿OIiV-/9_ ȾxQAeUҭ@t ~к\o$ bB BH\8gYO쫯Lf"t%MG3MN@RVk׸mǩ._WL4V7 o^лo=L +~K[?]Կ ڊ޽wRzu/mǨjՕk]N{j<G#ҵP/ԔP~X:)B(ShZ0 (@GzA@ EQҊka\v?m l)NͨZͨs_YF\e$IǒDb #~VPb5F{.]5.%M[L nIsyG77Sr=?/,-t٭!2OqO >\0Ub.[QIč4 ]vMF30Gz.to$)2 b6= ޲CjhvuQH:OS^}cŞ$o;{i{m, Z+4B67"W ˈe巿gj~Lt6mk4=ۀ`2$ﷃ C2M#HaB8*!^_&յ3W:6đb8Rʀ el;@Np5A 6;'q!'~Z__#E-[E5gЗ)ysF#mzG*yƽ"iVA ay[S Jcܳ/cҾnh?O^|Ue |i6D;+~yg/S>-ZݯԿ?L<#`Oiz?zݯ_&ᯅ#huɥZۦܰȉz^^'FxS1? z~d9|喣icmO)¢nM~I"5/{LFAǥ}&Th_F|*S}dUkO-%}]m|501̓kLAPHkJ熥7_)[ࣗ⥇V\إ?i$!Gn0vNtV?%v_R]oYR uu-aؓRe?+ $26 q_+C5̀֐9Z)|{ht}>[[}@Z gTqJʥHIɝ\ld*+{+xXq] H[& R{_Lqy<,s@5~0h=ɩZ[_ ͔SK2)Ӆby)2 h#٨ҿhH/)Dnygkd S$q<\W=_Rv:nuj)ޛqtLgMJr ? 9`~SE|1^i-[rnjhvnh[2UnYyI~?h"Ѣ˼巚H<$)Pd\z6= ^C➷㟈z|Vkexi|嗐JFpNr}|t()hG/o XXjW[k0IOYGsAePjYh&;#iZ,/n)l;\Rg?60[Ggkᧂt?$<:l^uhn&˗}xfE'j{?4ԼoᛋemoM$ß!\"ԑUB|RM]Fld``+9~ x)&l撜?ɷk?>7<ۛm>H/aIJ LNz ?Vo4Eågpa&X~ 0 d$5{/WNK &,љQfbĞK$I$MAƿۚF/zg;Cjj&.vZU$I<ᣖ3В2qHڥRC-*o$ݨc6q_`1u~mV>ۉe @ľX ?kۿh"PK^-Z?c/cyoxi2[ʲ; |פOؖ u$ |rqo<>x֍҃k?X1rx5[wyW6SM"4:ޜ[Ʊ> xB"=gOFӮFI>Spk͆GM##ٛg}+/_Ρc9fW({l凇|gxPЯNay`Ga_`Yj x!6p23k=of L+JgȥQNZW3ݎv?@kP3^i~u ͫK8{NCmLb2M':(ɫv9_|4мOw]Ũ [ h1B]233ڲૻ^Ȗ0p't|s>$VR #CMy4OnD $ TexK5PћRK[xm^Ue%/&TT;n,9xc{J4,e$\J>{2 @kw qikS{0.V ʑ*`1A5֡Tv[x_M{k: -LG)9 h784L4s ׆(^Yc'bU!a@ b>o}3SMvh5%3'S'x xz-a4]G?L. w;SV3&_f{1d+uWWw~l`aQMK7̒ ѐؓ7'<}-gq̖Y.o.JcKmE 3 ^-PF@=(+h?GR}+汫jqXĺi/m$̦Y.9|FXB$c,/~eiqmq}-Ƥ]^$L.LÆW_m0hͮ=[^ [7)Yoap 'icoa6讗7u;K91i| Gj^H_xhCZ@uQ$,KAcj˧Hl@I?|~4q%0>(Yh4_ϦfVy 4s#H r3>mtӖMYD“˃n| ddhmm$w~]nk˙/o/ 3ܨU@U**ֲkDT/ue{46Zu͍ܖ7Ӧ V̧*CxoA藤O#EZ~9E5UGZ!sѿjͰ~peOo?h_O_I}Si=<i?_Ÿ&MZZݯԿ?L<#`Og>" t}_3[a)~~VxF-sц,wLzOFO ЫżOC/U$?__4_}ڧ߷(lj-^sk_03_no-^sk_03_ӳa?io?XFJ $mj߇Z+/$mj#ī~YޏG?7赯/?"_",Wf{#e{G}IdP-8 zFN⏆Y49s`|{'5te'562I6PBBG8| ^ k}}?jWvGq*mS?>|M+Ğ[H{I'zzR- n}=s0>&fVXѶ̬WIN>/Rv#>k )tNj߃|ExUգOp{7G>$mjl1U)xuqRsaUw'e݇:Wȗ0"ix_> T#[dW$yc{e 0z]ߏm4OΧy,ogYn;#^˜f j7_͛NdõR4SXpdF\2847Vo"NTIon6&>s'#3xj6b+Ym4O002m'u:'77ufƓEsV&ڥʾ1 F6d%>?:{κ;Ռ9'}kXl1iLYiqem#Һ ,3&]rRkU8]J.4iB.?j 2x?pnq<3Z$h_/i~Z2v pHu =20k.x'֥I՗=Gwݞe.-'j?[TEZ>yQAaW5,xdיx;cJJ;}qmP?с7m##ltMTWGT&Ikw@#cSMCMԭJdOF |+{j~/g;<B[ j$Eܖ13Xҥ *՗VR~?d]K´tK: 2Ebڔ)#oa?㕰φ ҭtNk$-FDrGzj**Ȁ*((4Ph(((EQE(4PHxƶ3ݪ V֡L,QwQ@$WG(%F={}KOԼe}OTψY8Tcڜ?X]ꓵyBYY#iTF<M|Oyl^뚧d|)5¤d8kI-2,daRD΁7|gxoľ*5]r]KN'u&|#lI\6&?.3oebZ݋l plkI''gڰh%QSV(8 B jNNH'vrH#' ӂL+~=7~+ŗu{io`VKG|SN'$.8{ Z ojFcϴ|jO^ ia2MsB^Gi0 s)c򝏂c!Wt#N״WUsm{PK9V`Q6 KoDQF8^x⿇-:l"`UG1$ $n*@Nܺ_nfkg&vh9L/5dյ^jwZw<7cq} :jP\TTGFxQGƞWbC]DgkHȑHB;( Rs WEW/47gF9bp NIh@cXx7FJv\%z9Xq߮nRPo^ЛG~ޒqYg) >ӻ*ҤpO :^JӴ6Nu$ w"ξ,{M e>RMmg8Yԍl2v_Uо?c֮9-OVy̅I^] VA8^dV3uxF8jW:qlE2Z_}6dv8UD+A{%x~x4ST0ˣ$r3'Ϳs`A%cpi3zmYz[YZ BJdO,I[A3Ic {}2/g}43%d)$EQEQE endstream endobj 83 0 obj << /Type /Annot /Subtype /Link /A 84 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 333.5715 260.2500 492.5715 ] >> endobj 84 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig3.jpg) >> endobj 85 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 212 /ColorSpace /DeviceRGB /Filter /DCTDecode /BitsPerComponent 8 /Length 14498>> stream JFIF;CREATOR: gd-jpeg v1.0 (using IJG JPEG v62), quality = 90 C     C   ," }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?R4RPIK@ gU{}Rf ze|A$xĄ4ے=^a|"7A>j\]U/vѼ2E)NzXkn&*d@'vpjߘ3Ҿ Sduwզ%mH#`f8Y #mF6获ڬ^iy 2qq@`'ހ9,?h־ pחD:|asϫ/j`"a`S 9鿵EW oO?lc ￷ Ҫ`V-yJH@%uX/R|5ҟ4#`O<;+-GZfɡi^t߇<P698[|kռ]_:F|;5͌7qHV86.zPaykG>( ^-t+w:Tew cÞڟk^ |^@#?5l}[hߟ8nc@qE- oI]/=pSǝr9z:>V_~^ כ4|PD|Kx¾ &ge?x#ۺ}y{Yi]]ClHO'y(R#u$O,c6CM׼io-8KI+?|I|2k}n\i neߖf(K!\mԳ- HmgU8du= J_׊7x<)&_mk,2Z8P8H]o߉~GĚ&i \kӼ16%,ڳD@c @5>9~,h%|'D!0[!zUB2usWύ!hP˪ķ>'7jj'dK8fe`oۆb~ t ҟ7}Gş|>"}Þ)<6eUH9hˉɒb_;)i(KA G_QSO2 )~Dׇx!9]ӵ9'm[F1Ua؁{%~=eo&2Z7r2FxV $|pMyO/KK<#-4::f5̐js<:1g?xOSL !යkM,0\"~v0Xi~/>/;<״rek&4k^j:c?>Iυ ֺ[JfYzuqZٵa/Q4<_xRO<ڍWHQpaW oq{Ꮕ~_JӅ.VU.$XjH'8g|*DŽ9mW,|c?[}>JZkp}fA ȥn?(㞔½?νmῳ^pQEw2t)3!#g]V5\?[Ữ"y?.IW?7X#Ҵcu55$yDl𖩤j:^k'AjO=O:>H/_XӼGACkZ*HGU98a8$ euV'47nH oĭ7s[j)-4 V(`@HU*6ܠa5Tֿ'e6[kjʗ\;2yW#0+Nm'߶:ߛB1(I8^Ey/?g+c꧆S0m}H7- Lwk5Br7A%_ONsdW ũz.:>DX! r8[ZT~CFk4iF1[K,2H}XQ5m -_"w}EcVHf|сVeHmr8R>R A9W}Mè@F]9ʜgs.nbz|Sg#!TI^yʄ^-5{'"-,F@q>ԹRTcgL j#k0{њ| ޙźqP F vZ?% ں5TviatKYw/__e=D[\ 8P:NE|=k~6gXOqOex3'KH9ktm[ 9:џrku }J'9q6 N#ܱKڎ̐(K((4uK@JJZ3@iֲN8bB@hGa.[Buy,{;Oro=,At|{uefdӢb-#%^ : jqEbkFi(B4Q@ztG֎9n~ ldVϦ7jmPɁiUMJ`8Ȕگj |B/[Ri/+̧+InB1&p s}&cږV-PQE}+wu-d9W;GZB3VfcN֛W1ܦ֮~x||Y^[WR˞#;wMwU{ė+#o A|ooi:wZ?]~z[\cuI񜤱1VSkNk"mD5UI}z7Ͻ_FJϪ /gy |s$=~53 kj/eGs9\>-[ƺU!A<澍3pΖ"3Q$)6 jv{ۅ!2Ow;mP[O/ԵKbo'y?ǧXJZtu)yӃYZg^޸;$䓒Oz:$֓ijJG9b;y)39?-ۃ^?~!-mguIq"OܐLhn-nNҪ efiIF+vbIPu}fO^}{c5{ 3hVech45g3]e cڽO?<$`lJNkxW#R]O(<3㍐]++SѿWtrֺԶ(?1KIힵ%x 8|sDqj \]r= }k?[ jmko1+N¤hp4Q@h(PE(C΂%{)iefIe(u鎻8 N1i'9jͦ?O#^ᔞ\vџ}AX\7'-Wk)N);[mAs&[®:^]4lYBmi\3ᝂ~G}_icKψcxf<\I\AsZ_Q#"򪲖2.O ,&Kh( c2{cY諗M#]-|QgĹ^7H2?# +j?s5OknhRx)ÁEL5:j>R\XH Qtx[Ӌ SI ?3O/W·KD,?{n!ocW|dU7 ~'-Pq_&Y4VVcGӟzTj9QO\Rk/ 1jwP43뚄c0X;X5 Ƨ>K]BGmn9f'8ŽJׇl+i>%T?Jԣ(5fb((P(v ;Q@* LԠY̧Oo+3#i29/N[ǥUԴmb[K#JI \ޕYRzlRG攣"'-˖}ίحm/-QGCͯv.S9ZVienʬ"8/D՟##}5i>Wr6~QHcTE/Jv@3 ,{#w=;h*$'jy16-5ož%Telq 8?|}+ ^M((4U*n9&)8>R?򜮎UT)zZcԼZF.4dg^gNa-ե'9]{S~fY=YY>1hz*xsGѐw1_jS Ku }g{|_3|84HiO쫃mxX5=r e%+F}CFI9^dzΰ|w1jٷ7_\!W;s3?h 1f #Q!8^ITr$dsA VqtWiucwI&ݻve|'i^éD>հM"RH rq =G^1z\vVi:m;=Z"yB,߸?t! [ޙe[mgIaHscA/X}q>*hE36 T +QAdWa@(9/^fցE(W|MӢ5ȸswI_x3n+ ¿DXQo"-MާUPOr&ctSS^|_S)f8Hs^}gk_`Q~ug6lyKVw.@E~mWU=GvpVtݫ|6 Az_|leA1BpK9'$'>Sw摭3QSbc8*@6 zֳ1dʨT֤}>gڎ)8Hƛ2Z'd٫֢4-Rr}.AUՇx:__O:Pygsf펥$SE6GVHiG7 ?XނD |NG/%A̢Y3/,'|[_f'1q_xK-JQvu9S_\xđV7@<pJ:5Q"u *zFk/Vg^/H=? <~} +}Jk[R{yJ25ymʃQkў_zu>W|Im!#[ŇVߵZq*[#uejZŹKwF_07\9r4 a75Kmc++Z|_Ne1?z?=|#8W`ZQCGcxl_6˨f!hE׼IuiTp[j~9 ihx?!kutkszש?~)_#%.㐔v c3O6d[i1[2L]yTlNh?K_.tB`_g!̬̊g7AI~;ꨯ>au-)LQ%R**с/n>6%?g_*`'9 Twk&F@Rz?g5on#جv1fvQ4|muePHvEq+| ;I rv > 2-(uIIܲyc$z7 žjOoR8'p= =x4 [=lm-ٷyBFdOe諀=+Z(T3ElTHK2qL?Zaq{%Wpw߁dR?1@EF&_zdHꑯWbS@7C_~v[ucwgP_dھh67cc{;D%}B#7B0t$gZ uOܓ+^rR0ԣ4{vO ,{}Ww#W|.JFSMUdYUgR!چw|KnHgN+P}@5wprqھ7yfIC5ٙJ1xڪiѯ8l`i  =+[6쑆F;WkG١AqQgKoY&Ծ&jik.$y~wq_~k?+[hj6}I5^ZG2SE{!EP1F(Pbƞo<i&el@>? # ^ފ|6y ˭]٪YQ{k:cyp'h _ݼzm-#v6(\)@a)L7 5Ȋ81|9d s?]nl;HJ mQ<#=~|C0"͉Ԥ!;IG^$ )pX7 ~"~ӯ;I TGrLn^6hO3GY$-ڤ3e}2vA'+]5gK8#0B8'S@.Z6wF+pيlf_֩,|xΤ`zdv^)=9)#^k& 9򶺚lar+6TdVlIqLkCg0-S$p ' WC4M7|mK[K bc1DJܜn3Ztd-ow+>|CJtaV{Mi77m!S$j+ƣǾkǖ[^;Y} SY]|zjw4W^81z oê[ock#Y ơ]yoXg)YRR0k|tg'{r|#MQ>ԭg!Ih ]]bc_]W|[?2Yx~+߂ůي72I+,% 1Nx ATw Zֳoy}kϳJc4 Q]hk +hto+WU-ݧ19LgjsOcѺqtnfг)o'Y7^}j7¯ 6iJo$ !2dĜc0l?i/mڔG<fAK+c#a?_ͼSj1X X~,G's( A9V <#w-E9x%>@>p98J<-즗6ȴs3+ RKZ'uKJ$[=<|H8u ~ Zom&Ux[.1}Pqk(NQEW"5~0r*hi7^M |k,άO̪U㜫c85rx9g4Ž\Z-Ӵ,!rr@p;q@7hڴ040Q$ۻhcpN3<^o~{ /MyR Hnry (<~+3jqZXvIJݳ8+&nҚmಊA=]al&'̻KFP|˕ W ź LUK8eV8 #WbOyD6^*[]2M[ f;eY0,a[%CzƓk:BGӬh&'ywɆ!6QY~"l-{UX26I$'$`h P\nl~iG՝M{G]>s~_sPUjq'trCy)v#zƑUUU uDQG@J(#FP~$ӼO$DW RO嵺3MP37_`X dZO4/*>bEYBwG He!6שk׾; YbMRRk:N>oW5{⯆1#}ë^ݖu)A?:7veآq"Z匜`׊lugˢFɧ-֦V )|s3o/^G,A"܈-ga#:$B =9;yq'c]c@}Ng(2CFq@\x-?i>!ԭ=/[Z佐GȦ+О !I׷StWM8?n{7vӣDx1BT]VGk^g[YY}f*6EB.N"$ j~o5AS{gHyB]zm:e :#wfb6U3WO>6ҵxZNxB\E>v0W $(J (8 e`Hۙ&4l? 2ӿg}j]vQ5+yeH VxV@p,''19@(QQE ZJ(hEQEJEl涎K5-eOl\*e=M-+]& th#X}K17(Q@PEP7kV/n/9-J|˳z0en F^k7Ǫbk[{ˤy 0'ckżsS񗍵GC (/,` Nl*bUY l Υs4xeY%HfKuH2; xf4k6l KxR QI p _ jl۝E (Eh-m%ը$6c<0&߁mdӜ[[*)opcy+ + \(Q@0 g>b gҞ8((J3(֊(r( ( ( 1EQ((b(Q@()hJ((tJ1EQ(Q@ endstream endobj 86 0 obj << /Type /XObject /Subtype /Image /Width 600 /Height 205 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 600 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 541>> stream xA 0 =" ʝ<2;EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$Eb(O endstream endobj 87 0 obj << /Type /XObject /Subtype /Image /Width 600 /Height 205 /SMask 86 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 600 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 85894>> stream xy&Eu7|NUu;wUE(IFq(F$L5&AQ# "0603w<]UꜪ~$~qZJ B"T ΀03t'L~1:bXFulD5׳DVT("LjP]utW)L&[ @)Du]/ƌm"d0\aԅPL'I$!xVΉ"$:109$B1%8Xc az3!3gn\ug 3.;BTd `Q@2Rg4%sr|rA+ Hq % ADqdq;1%F3̋R6q$5(OVSD _nJZeY͜KN`b$ 'uʷDq$y1q4+M],b%HB)} qf)j12{U t7Ȇϼ.q|ģ!&R#8U]9BWt uiͧ!e ]!r`+͞W/ ]#c6|؝"cn9jR"O(,bD@{7⼼e樚1 A\Q8p&Gc8ϵ$a40G#(J@"$ct='tk@&\ Ζ|q:_KvEPJV D#;1Q`lFee D!5&v!-*#:gN @E_95ӓDJWɺh1)#2f #7t,KXG +D^l(ba$K$jNjI.:!kIA):` ,x!̒tl?@R! YJY8A#W4[ Bl]FXIyb),}P@W1Bp<$@O"*Qր9hy@7,I8a.k#cS&hf+' . $3Œdw0tHACÔiq~ø8p6_@Xx V>qύBAC7"1"eO#KlȮB2hJdԙ%R:Ht" Bv񎐐 U|X4 d#1W>*˜څ xI1 M#aH#)Np _(xq'扰3ىq*y1pbL|l!Kb.D8J? 6,( l=SFq|qP#`U"d9K)ӌP5k0 ?ȋIiF$U^'/J !IBbIHn!W.3U#(8فt+I 40܅`2 @?nydIQB{bK2*-X~ ;Er 7rG&`OvSt1׳55(T["!g3.1"%QƤ,>LEDW92xL]#%{QYKd(p5-%$iȤh=Xq)҉LncBO6bc渆g+O?)Q!eKPFZ ,! 3Фlb)l޸e0$ٙaE$Ob}3`V̱L*e !s|J=?f=6qPDy.im{ߎ} ,BgR?Ƹ^ ^OkvW^ĸX?_3)=QX'uIj;]/%yj'qq3ƒ}O %QNAcdȄRW&d͢ KzJro# \\{!e|e7G1d--3FXwŔ_Rk9l"1Jvx(u8V/7\eT3k`7L,qxIiOh1y^ESW%.@>y RtPQ0jnzFi>@ii:0JJR:VLXA#9s4X|{ǓS,LCS׀.VAn\ِ`Җʴx%VKtγY{Q-1a LQV)2u1:I*r#q3/bEyf  A[=3}ȁ{'m bP72PmL }]r5ZQyDRM+BvCp%`VP':Ulȋ[2DW rDV*MmItߓ Pb$ln|FZKr$(x@,l;Z158ݕoްmyuo̧ O=\_1ന"DeRF`Ag^ ?2_^t7hf\NwGb4@ Lr+#<A6Hp$Od"xm\JMbvPE%/W)ːHrW̿rϣqOܥ#egOS䔀{< HE;sR슇?C-|!݈줹l͎PKz*W&tԤ?b-Ló\f]r#3&$+JUQPZFˁECc/05<_=O^ӌ\S}oHkMMVgp=6_&^'rofN~.a, 8dec?:&D."ؒwKxMc{% @ TTTIoq -*WzŐHVEŲѱKB@6̑-9(q_m kd>#O:3K 1;NAdθOBrhlxoQa(Z9q,IβN $]D㌉<8d%8d:Kܔno&ҌT)$;3D&j&m J1N0[PUsF?)oag DYp( I3 N#]y͛mͳ8gw͍{ܞM[xU?-nҎ7Av[gͣ5?keg{~kV\\Xw=[@OYC"'`NpYdI{uxK!E,'jQ1k>r_> ¼+\E;Y`*~sE$x=HƞEx*9^JqJQ'7I?A =Arp?ʕ_s&ڕ7<}.vYg[~pkw]q􁧟xkUn_wkUžO' zEӨůpݺO:_9i=Qk~[~ǓNtMd#2HY氃 G8).Ed rv3čBi9"fc)tZvށ{ח@1k=JtW_y?m[[:Y3{#sוNB@EKOp'WI] ܷ!zO=f`>ΆYTGx!0h?xabFGf# SQ'cD+J0;rRTS.א$sLbŤ{ʩ!?728guaV-h8ejH$~1! -/COi/RQ2,.KNB giR8W:tL Q@ND;d#b# |] iIBPhTޕ*eqUhr5&@HִP8vꭿڵw~=cdEHY斖2LLQL( a1;`Z'lj[x.$ǫ(d| 4"E^A;=,Qv85Mm;u [Zl>h8sb^ArK"ĘOejb G ~rr"hUT`K6k%e;\RVAȚƐH_IN$H ! ] vݐ2*L8"0y?[$Ǜ&ݢ !`sXMKr>Ʉ# t, RLۧ.`%NddDak+I]@V0\'[8'Smt 7}I5X;fyG^؛J48BWTw1 XVY\@ՃzOM_X)ZGژh۶λ߰&m-s#뽁ŖeDq40#@AS/MێbQKYڵ(l #tQՖ"cK\kNg_g W9 ab{t)5%D]'#Z|•((1ёx weҡ8 [ r WAkP`aUgWD]{֭6и;:#KܫeqIlD)ސ:dq&sVO>1!*% Y #̑h~> {< АP~#N,ʠ :&񜓶z󓱣8D>A>+cx,9[M sZ anŹDH+)s;I.Q39ϣ'Y3!Ʈc|r $&3dHq%3/&_#3 /94TrB&;z _34 N1R2QwFDIDDP~zCwV7l?mׯpMcuU[GמO>X4;mqm&3;җi'3DW^yYhL+Uv~_UM]m݊Z?`? A~Ls /3v9i#1%l؁20ȧ0m2($BK"%>:9el"D*0.'4-hTiGs sC3r?WSe'̑+0fͬtF.0\WiÎnr_^ِEt^G %QoK==h{KOth%ivz]rֲL\ڎKv.aN̦~% iB=4`F^?n\K^RiiGY[z ^~jnu+ցB+ƣ#V^.R+FP ,6 u6h+Q[f\hıiu5a-\Wx]U- =S/ uCL?x" = 'mD.wM;U I.ҖyY lw ( ƭ"D01vֶP87?ePe彃xTE#XD'nYU,!\2G/WgA-@.~7\";aZdQ9@ DTX9[{d=Tj*CFlYohlkQ ʓDF'En#s4xj 8mS+m z[Q`Ѓm_0s6-ʴQ |~IY;m#UGPeZB 'hL4?zlEr烇mc6ZA H) MqE)W~VI?p9v_#ٖT'?& Ă  5VRz2zUz*޷*1QY( -m<9( oJ[pi7 U?]_@Ldێ#; C,jPD Ҡ?#T Oh"Vr͆0 ;_N>qQm; z<=-ms[n#NJY z#ܙU~7B!m}=}Coos{$r(Q[MNG5w?*}/ʖ|!*݋%MD;GtΝm{[ŨCEVGp<*k fwY9]""5:\[t 7ypo;?JhMs۹=mٟFVA|!xD)-#jSj:1N)H>B@Penع-vBp/4ܵtk)`Q*arFNߎgڤˇoCҭY;Jp,9,sr5($af^Y3a%:J5iOhHGCAϨHB"B%U{=,H!򳜉="yFܧ^) D?RJyqy:HR#HrO顮J0DWι,s=d8TKywlmO'ȍXC <\ G@iE@1C?}#HJmTO=xP)P=iUU RXD;#OFimkZݦiP)"mlS)B-Y )@6 "}vDd1.,H+zvY뀀BcLQvAx4D2Fx{HD>Gڢ0?5 ,ٹ6P;/FD`֗eւQF"4wkD>P)::ۺQZ) 1P3 mֹP֬MykmaBֶD9[(sijk[k[P[kIGrGhJDd!zE>C!#8k\a CZ뺮۶m۶hh6Fc c\Pkv<:_S"z%"x07MkGsss`DT~/S$>ZkcFQ4eYx[xGY9l]~~~7M3m1m*7(\W:ܹoGeY/Z[Z[׵wQ9犢Fm.JT'EY{6"j<@ke.˲( '(Z[U="baa~aa(J`ЇXŶmeY!!#TXkpMywޓ'ij"ǣiBh%]]ж"`02FDQmz_Uѡ&b(dA^FDn6Ƅ_U?Ry5kǡps@mk{ 3Z˼R1@~=,ą 꺮m-ywpnEeaGԬC. k[τeyFI|nN?<EE<<ߤ̒7(AT^ƌDR@x'g5UjF~ utf9|a-83*Yq%Ñ(^v("ʻ_Qv/4‹V1bImۮ\1*ӫ*xC&¸"YPkb% oG~)riNy0  LzuKm3Uaz _{҇0޻|[~t ݲ,uZmC, Ӷ`]EQ}_>~zR}x]"jUJ!_|{ԋoyw‰/{1ߌ=A6!v駎-"jR/[^O^p{Q:k]vL5C|׻O:G}1oo־mR0f]Ow aD)8!|yidWBubSʸ8S| jdA}?8"FJ%vw K_;! =&gEQj7n/xm2;}uZwܽ*._SJ;ۺ>Sr‰'zʓun|=D:?oÄ#!pfRǞR7)zaK6oI$>Ȼ1;"0, ye&m}[/=~w~F]wugLc.7qʕwm Q]_p|ӫz}/]'xxjj4LSITP)_ऑQSX6?4ǴISڅ9`(UFք|9& Bo5P<&MXs+G#NDQt># q{9Quz}\{E?\3TM0ZW}gگ'"b8=y77;+f镫[ BYá88v^>1KbfUy-S2}a3Ir]8di@f2|(ޮ{[^0=b=} 7Ph)z|u=~.+F O9<7R0R<Wuͮ{|a_ek׮=ϸ[>mݺuzfo w?p#x/%_x}OGgJWm~/~sy~}u?X/}l[Zk]w{9y\r 7ܰnk+?ϐk'} ^uUOMZ_?|;~]wuu]?I|-Ї O9=y~;s_xu^sϯ^~9 ^ R|/^v)_9Ӂ#:檫gÆN?=o{z.SO{곟|7_/[3uL!CS9N;knB ŨK9L]64i8.ndY!q/hj/yV'@1yVַPQR'_4>Oxz,of4zV׾ֶ/ijz=mg> /Ck}tI䧎8∪RCdyrnW&)%t#EV- BIm;j(TSd'Oʜ-Hlr,LLQRN`<,@g(Jk[./:y֢RFthOP)[n馷/Q]/}^= Fvw!*aVBdqNT\2@2]L- ˥aOB\2 l-2l*7!Rvwν:Ǿ-oލozӛwO>I{UW_7pʫf8O^[v} QivY[Y9ڴiӺu?`'׽y9䐲4Vz?|[|]׾mosѸy㟾_ʅ^O|O:I\VpV RS7p_]r_?=ꫯo:n_9i(?Oo+_=yg{%_֭[ްozƍ]W5\7|;_Ep^#xnvM\+?.:Eמw?mo _Wkkwl޺n> LEnW[K-)8c/q!!9hŋx̹CiRC'tŪlj"'s'vJAStGx2^egJ x:L ֺWfV ^,Jh\}6>Ox`8*زe?cysgffڶ"Ѡ?w}i˲46,DJƹM!EQc'\.ե vFDWm b'r p<ʲ'AaSd)%(!t'2d[FA4#9-)t70ǽ^VkUo{+\|UU5M]x<^\η]/fN>33ֹ-[Yp8غu҅Ro]jf|X%kbFKOdۉ!Gfwff@ )aAw%E-=99p̪ tQ զMlܸxӟzƿ|v4MYO|BU>q}pqavM7}Yg=h?񚫯]j'Zh<=xvK/pa\Yz춛n(Yg5=cMweeDÏ(|:ȃ>dUGyT]7|n;~|GzSN;G wdJk]rQGZk5Mkvu׳u֪5z)֭;ㆃxȮ{uÍ?\]RO;W}xA[w 'PeUnZgM>t!s$+aBPhK9@"H dqhs,#L9RF,,f6:noh1nG 0pnJEDzM~mu}ۏn~ްbz㽻6np'}ǝp¥^zGX~}]J,K])eHAiwb)\&"Dݖb))'`bZ- tN%ZyeG·:.'ay@k]_0F۶Zχ5}m蓟e_g}V^+k6=6MagsëWe|׻vm ;C~R, ?J=1߄!3k`W}yRQFik&_(icfggwkzyq=.g^+hA;7X 7wso{}~K_:;{VX+8] xMՓ|We,TU(<(L5ܼSf~nSԠ?`8׷n]X8;_bŊAH#(T9u6;JEe[[BP9ܠ޹UEm|߻+G{66Q4Ma y:755U׍e4*˪N?W'>񤗼}Wr {ò^ϗH.y$=e=,mT=x4^1=EDhc#@x-_}fGs_veOx=Цi۶y쳟?~Z^(p֚; ;a;؎ B|ɰv0wy*pBԋp0U"{zG{/zQG>Gk3+ԡz!{'vq.r%p7Cpk"y_%,1sFܶ۶.Lv]8gkBG?z嗟Dok+mo=9)޻9ue5Z\Ckgw1o6o-oQCrF`_ٿrs(˦o6ȶ]e48[ǥζ,ymtpF׿˲Q@@mkBkh$E@@H\[YZԈHm=S|K>. ._ok[Z$$m]Z/*5zgUٿ~[|3|+vnM=~҅ȡjںԸ8DeQ=_\{w?ֵvu\uq~h]SLOw Z뛦7UhӶ|Mܖl@RmLQ9W](6^U' :GWEQ]FzÆ k/_{GH+m%*ERF@{N  jH!gf,X( kk}WFz돮g-[7;D\@xWYCY֊j$g{~k[ \߽SO쐃(=/s@ue@@y5o01PO? wm7fR=_s>ȩ~[o6ga 'T:Qϝ7wg͞3LؿN;yEcf;̌QJHovR瞽=IlsOZ]ves+f̘1wKn~l6+7lذl}ۯZhk~;:n8wGE.[{*ѵZmڴ #thb!@ 5ZkDґBP AXRz($ {B(k@`!A%Z`-AYGSʚƭ |=M7P#ɡVz y@ AahFdFADk HDFAJDK#֢<(o4sH+DA5!Y)dB)l_'W_ve3z{{F%I)gBi?*a+A@ uVKϋ" 5¾Z}K/cfB(51"DF&!30<)&o~B  RBIxɺ;k RC!Ea@ߓahzz{hhL<~7MT6S" yJ );FB $A;>  {L% eRkEH UMZ% yzR[BzRy}D Ri) @(PRl-*?}zS 6V _&TYcRhmT( F#2FW*@iSRI6lm m=R UzOdQ(`!!=1B("7j&$ %_}uPQz+X =VXFd!Apd%RD*hKkk}Ƹq}CZҍmEl+;dvMR6J_v![M*ZN:=@;k:@Z% 0P[ dPy!JPGL hjmppLd--dթ^.~ L̩;)t'c@NrrLP]d^*.w“+kTDF{_ )tWUO[`H! *JPaM=!1j^oV*lEVJn!2#˧Gk7b,[uW;ʵΆ͓ɖ$ffa,x+Hr[@d g'F⍡=ȅd!`FD!@   ѭBD"KĘ:qvD,D|{37=~ srIfNZ6T|[P=cX5K {"0;!sp̜ dwP33(ٙ !"JɎi !uve, !P#Z  b-+!1>A[F(.LhA $d$$Zb`S@L D@{Nu@2t `- ,Q0iJ ֪8éwd;3 &!%K̞'$ D$qc<Ġɺ5)%HAČ1B!35R @%V_&Nn51JnH B ˂vB9}f*2sU0ݥ{S}Ѕt'2033dF d- RҐ%k& R)$jfN~uh V;z66/OVz8 Q!h6R*$@ (4kb) iS3`F` Uk+vQkoYK I {F @12 w923HT O h0Pd<'k5Rj#@ =X+$k=Rn;!vcO3V"JIcBalSJ ҖXIB[ADL t2NN\0`Y̜N|T(BLHd2@FRX]DJsYl4291Q1HHi"@`$dH[#1'6&Ym9av|w EY0['r6 ICaY2r 9E0`Xf[)RDIDJF}zuSW=Q"(d#7n})z~Og}{!J q/A$ &&F4 4M=F݉&N@! = f(-y6HZ#-TTo1&zuc#ZzzjLRڴUKV7דf&G!<x[Jr۔$R1 zj5)ƍSS6ׯ[/'N*}wٙY!ub׮sy$+2PHΙfJ w)O{ k̡,#g_r>@\wiK/lL2'ۮASq1cB|-3}.wR}޽Zk`[]ꨧVg>;YꟿիVGZ|8 @ނg}HH?/s>w"UWw3;9TI^su}K U/ח׮֞vi;0G' i @2)R{~1WI>]FC1qDd^_+ݰqäI `˫qܸqJEyB(BݶwՇF_T0TP`dg}| -dW3NhѢ˗Yd )╨eZv^:wtVt_2ޙ)B'; P>)PFˌưزV)"EZv^Z"N12,EXDtK?ӟwun휿??b„ \se}F.s^~O?}q| !"{Ŋ05U4en;idDk¥6.MTPWV%>oFzJ!(/MCDKMΞ3뤓|ᜯ|_|qm?˿ǿ/SԱs'ҪO>yҶ˥~h?wRD$;[n׉DWv;-xO H`4F@ @KL084ԘaW^ 7l%K>W7>{q{~iӦ3tkR800/}SNm?ǯ_^2eW򕞞qD9 nZ|ڵDg9sٳF} x8Z?sZrx twm1ɟRL({K)>$!qLb&C=(b+J,4rJ[%:mMUٮRyZ nSBkҥK'M4o<)宻Eѽ޷>?g>kqNkl61ZknEzT!d.̽j{s<v-;U6^nقE:vX3֋)ꥠb,NAAm$PX6Z38㤓N?nݺ~'tڵko.Z.]tv;~O~zN;$ㅹ1XkWZ588h]z/ǟuY~nO,0yg~rJRi4A4Mݸ⋂3v)_ dMFbݫ,0F“={#6-e&řrs$rt1\tE\p%K&MME{4;39G=Nq1K(aiٜT4fM$G(߉P'/mεַ_Ja!g=WUNt\#:uۿs=?ĉJ}֬YOO4a„3<ӑ'<2P\hu5l?n0k֬ɓ',Qq̼;i*bs+]Hy+:ht=obaiŸН[RjhhhӦM.ZkLAJ+⮻},X1z1cu1l6M)7nܸrJkmE+W?~|___Z}' 5.Wl*?Yf^{e]ƍ~K>˖-ȹǐK)]7d2|o<<ϻ^HF9*kl] B^rhŖ\LTl]zS1}3g.\8qDD3g;Z3gΙ3'A#~vڇ~xժUwG4iҚ5kz+V,ZO}}ta D,x[C 5oT:g7r3"Tl,Er$gw*X$75?9'RE̩^`:-p<2ʕ+o+V<'w_׋}>~O~sέT*SO=SO\{+pK!Jx.`T9$,*TD)V4{]u؆OQ i'sbcyg}vܹCCC/rOOի~+W'N {YbŶn|fҤIFo~'<NT*%6"-^Y+-j!sT>2fx&U=؊ :n^44jz3&Nj )1nnGu.)&.9 x:b( TR,H#3k}w9}^ م]E9K)bC!W"p^d9B#9lNJq)H3kEVƘ-8_B5(11nܐԨDQ^jxA~:t1?rN: 11BjєӁIIE̖@%xH)kA%(CV)ZZ)3)-Y!dEQvJt.SZ4gr.8yR#?BݩE4KҜPjjE1{h4R̠<Q%BDRÒGVKH3,Shu0ZsyrAlJ)" Lf&fWZ묈5<"A*F^浘<g}qd S, )M "tgݣ t;!zUӏȈJBIfa$[$$d`B֗L``J_"3{/L،\ɰ9wT8'%ٰ v$vu>,R$v9%ٺVmFR Mo]T]FQk4FK0@m{u.Ub["d6byF(fȽZi`݅G>BbxJ!#fler40le K`&A%ce?;*"q]yI.y,vWHݩk;C@S7e4Gh֥Z30D(Ox*Ǎk6C)ePmְT|Tab{(C60vy!-OT(iZK$nWEilFLʗQdHWB ZH$oa_;b 22E ZEXnk$(Պ֭BDeHkw[׌4R۞NJ ۩}[zGHufhXmmfXl:2[Z)UFTiיTBc hA#VQEQJ)`6 hN渆9{KK[$n[h1~/DD@m;8yh $7c[!e*6wяN2MogYIe9/TS03-)1V_ROm'#zgJ%X<֯{y Q )Ϙ51'zk+7j=/{ `:Ҁ" n.i&8)N/7%m#@XrѮ%mYoK<6'K !()ß?j~9<79C9kL7(7=/|Da(k nUꕓg >ujYIU(B~ 츍6VSA]_&`Fa: P(ꚿ?piu|_ON:Ukr_8 .#0.m< ߯zbL`lSpZ3&1d'J|M}Nb[)l[Zt~T>VSI85l%Q[ji_3Za2J)ᖝ`>%]ۖfo+H5OFQ[k=OFQJ!0˯:O mՍ>M6Uy f{cW^ꗤ>':K;Sj;J9{9\F ߤkeBʝƍ5x3N3s!m1QQw߽y}Ͽr\6֯;w 'PJ3 h4yz)0aȮZR^:m*b=k-"$<Ǔնns)ZoA3Z05V> qĞ HZd9MҊ$1WnGāfZ&";F$*&16O/#nv/alY0[?ksӮNXE8$grW\Ͼ\>' q晿կvݻˡZ y3:ꨣΝ:,Wg&nk8 խH9ISXa|AMq vm%Yl-mhZSJiD\V{D16uaӦMR^|%o6 g}A rG{׃:8c7i1]7 P,ڞ\2rٙ[h9BȜFV̈́lLu,srM5 Oc^\Ni3weҁ!d!dLpC濖J%nvvgI N)qKH\.9i,wɀ(e$~6$S](3g0;SMRHBr9(Ħ)7 %Qk6H^f ϙ=1cFZ)ک-!mIg;23WHXCp<MZ\ں^,DqsBn1mi8uk=M&?;Rl1ҪAAO!H|;`"^x۳ٷ|!>no3p/ΙuՏ|}5k 'NfӍ O-NZ2O%$ޥEKmH ̙ c6QgR8[6FT[2M)W6Wٶiz2mXd ^oVGqk[W 0}[n-4x?8X!2w%KA0a8%<;<&*0, R2MͩB'h7 )%VtӲa(o `d=_pt{S0<ޔ)km`6 cܰG{\pA߸WZ%b<-[쳟skM;@".^? S6a+Kja#WJ6B#W1"f#gt$ƺeZxϟ|[JzUēg~Z6uS>K.oWvھq29zף°K{TF2 Kg7n•X0Į߄Rd裛7w_wP/ˇ|az)ɧH~CpYxC$9eDR Z3&{QCK/{fd-7veqѢ֭0#|GxW7;3gN &`Fd`B(ML wA!*X"(%͛_Wwq_NG'ŋ+_{կ~mwlm%&o;YRLFDa3}Ϻk4I &+1؊ፈ>I `"_JV06+V,za= Icl ̛foOmYw}_ɓGNߏ'mG7.6,A|c+oM 8lJŕ+m&M ˗_z?}5zHO/Zbvsf Q  `A*1 Cb*CGyvV}(%Ǐ=kϮ每=#Pooիl瞇zp΁EzҤIz; _SL6Q-o` 6xn Y ~nŊ{,GpIկ=u.gɌ3N8 8S{zj{w}k.LAPqJ@D,ZIy-7-_{ooW^9{BЩ`_ZuyO*%ͤIwu6f8Ν;'&txOc?u!Ͽ`(Ï,i瞞?3fL7ou˞] 3g^nٳzɅ;-T:0^}晧 BD:}0h m  ^`QJn;y)S>īyEo<#z=s֬yҧؤ`b:c9s"cZ 5BȰ}_km}'6 b4ѢEy0lNnvX?x^gf3{=cC!%w1=2V H $`A;>{hP7 M^MŦh'D`m" HJr`Jynկ1Z;Cl{ @d-= Ω G% `'Hj$gGCHt-dҹc* rrUCS iN]j̓[}8y7l S3LΪ1=Sgk?PvC6`\"uXE|NZ v*d)qkIね)؉-^w:i\ȊB*Ҧ `v2+Љ.N 8^II`L.nu("+d@@СAi^0- !ܩEo,V>| .)Vվ3' S &S0(mI۠ `QN_]^Aʡ9KJ>s}g4kuGT]w3CNTԆNշטU p'""r7ԵA\g+JUszVLiXBv1Q* '%ӝB3E1Bh 9 e[PU{jQ-煛0t'(&$ƚ/<xyM]LU)^l)Ů a|KH;@WiuRw"7Mx:f+bh"0;\jQXi+C+P& Xӂ@ݧ"A2[b`l n_tL$uA+]ǒQ]_|}˄@Ee`4 Ԛ@EOiJDZ `D"`bm]bv~W^z5{ү^ߜmW}Ј$ H*1NTp;x=H2NgkF "0 m * /@h)Y eJ2q{ 2ɖIe - ~ZSw.O!wHN66IÔ$SEçS I+PDɖ@[zj"I0l"x,0eˡ|dk(0*i@eDvi-QT-r[#٠I:dc  1Xk-"H " x l9dC-:w`UV$ l2"vp^fB½WwgưRBvArϻ{VQ;RVy)#ff)df!j+:R(% +H+աFvցRJ"xF[Xe ck `"22` XJS$Ffw.3[D`dHi <h]m"BDBjjF`CHDRCkY*)mu ^$ % @ҡR̀`-6/4}dmZ[D4&B ~x $6MIZ0lZfolf{>#5#F ւkٶdЍ$ Ln @~{Сؼyw3cmg}#`6 ?,s={l4ƒ9̌lY_?E??8>-[sO?!o?XH Dq]Vll$>~4ܺ,ټysR>w7^ku=׬;vuDy[CO,Y"?GW(WնDRxܨνs]viNBx̶^{{w֬YFJ {PmSG1~8G}Q":CX^ @U3l Eb,bwSDff6n"U1hTz}hb @$2q݆ Z`e@\h\ 6X6 mmz(4̡ĈOR^^dIX#Zg6կ?!}wbЄ_7nFm~7!kK/3@5"F{M*6ٯ$I=0"ڄˍf_<̳9s~#Fկws93T3=/٥˖1{ `}u^x1fƍg}aFtF6ߦ B2(ſсněoo~u˞x+6oO| x≽렃Қ-f?-yb>rÏlܸCA|ƍ|pB03]7ӧzO<V]ov{;GM4ippp'O^poh4w5͹;v3f!:CFzta8_Iėpx^f5^` /<Ohs^{>>ǟxꫯWZ(Ptu"ZYmْ GL/FR2ò-_7 z38cٲeR /</^\T-^kC;cႅW]uwsνJ|i4Ƙ~xΜ9}}}B;}Ri==ZWs+|ۓO>duV3fJ)}wׯwBJ)!رc7nXKn\y^0 ]z .ZhD,JJr /I}V\ FR R:N?p;[h(< 3 4[:Ea:s[ЖNe;P3"{o!Nn/r#96{e]{|_\|3?곟W^yG_o~/˽[hPd%Fw~{^WZiSOk!G; 4a%a$ポtdu1Bh6mrM3cuN:o~_|կR솀RMvf9$(ڦ%Ọ;- R.geGSO,YÏE?fB3OvOR!""r}^ !!^;fOOR*- ȍyҥ_sraJ)c=vjRD=uRd'vLKsEa`49CaZyTtL!fs] Y̔M3ܢ6M0yo\.Ϝ9SN>Os1s " x￿֚\:uĉ|}Z׬nZ:ќiT JS-QlJ3+N/"]܉NV1!*.=Td;A1FJ̣G^n]٬T*f3w޹T*M4i̘1,4iҚ5kyTueɠʷ%¬'-:1f)nݺŋk׿\0aŽ;x뭷Zk7l&!Nw]wƍB3Ey!@g*]-!'_84  jZVN=}"8cn z{ pˎ7+˳f6l8ꡇ:wܳ:kڴi{iG+8s&L0zjFx'N<3O:Yfqw{zzNiV\l6}OΏ<ȋ/㏟0aB =2".T[&2aIk1ӻI[h|))̜'/OvNE  0*]HdŎHaxW}ʶXE>bOW~ /|s}Æ {qjժ/|͚5fsgzzz$jVCġs9gƌ Z2n2W3)@Oj s%%w2B>i ԒS(BWH9Vke e˖=sr?O6Ow;iҤ 6z;3sxM6xgo}sz: iMd~&w$sS4ŖZ̉˛M3dZd4 [&dF$Bi܅IPBB13)a-UJ iHD;YT 0PJ1IS"Xf"$%$_*EXA`3WzYB0a$D$ɧ;Zl[)j-$R(Z}@BJbٖ@@DdBF#Xt|lIO c Pk  Xmү0-0Bf KղFExmBK0"0d j  D&$`k RH":H  . ,;5K^u.hIhn}OtBSf >p#DG? zR10 Y!H2t&; HqdKKNG%AOA @JNx5m\D@ -0 JeF!Dd]K:@pWQp2XD! h#$1Fྡྷ)NκjTjx֤EFXކI 0x§HAzr (rь("@aL5kmJ+Uz7o,R0 {!""hMD40-8ٖ]:T)KNW*jCiv}8]㉜|au3)][GYk#jZRJh4RJwѠz\.7qp9SZIc2+,E@r3es,25v9L]gYhGE2^ӥwEwض[w9^ d̈T71J)ctfV+F eLB0 \ p WYcTEsN-ea]є#  MP))a7 ԥa)ֺ'L|)C:'7;R}٨7Q)I̶[@Hq;Pptlof)̏>)o3f,Zt=ƘJ$%5ajSem,+Zk ;N;S &[n,65ﱩ6&r9By$ǎl3+ '&6rGG[ZEI$fP̥R)BzeBRJP\(V.y6Ƃ{A rI F3$! "7'4k$t8RMS!Ex"HDx ItsfȜ|tZ14ˌ1SY%\ (ia 2 @^qG'e`]T IA^IY7J>H!rlj !ȅޞjVZCFa\D(qԲq&q_38s;|ʊsV˗}]ք} `x~8800+6m>qfB ^z%'|SL-(3x{-5$xMW'JQV8ʻYYc6奌 jtrQFb1\{eH=s.$6̹V RdD#5i[DIH_x x1u@BsK EVn ;l.\x-4jWa}O>3w/T{oӢN$L'(=d"HiT 0 +u{pisMws"pBE ayA!6KQ _[wdlpT$s}L3U*Pp"6DDpSY ,sf\.e]oɳO2eRVYp;Bm1 H-SI9tm ԁIHܼ֒A@QhtRL-ȍ]a+C۪KF:K.O}F=BWlZ O )Г =EB)zJcY)BdSH \vܹ6o\k ._[^{N}wyg4}O쉒$AHD'{ZȓyZJK.:wSB0񍾈]NJ `{{RZy !) i-꿃26P<m-m0aqSѺp"(*5F!.;)FgK3 $Q&ظ!v*PjsQ9U=gVubqK X0f`OĻ&evw?uGN==~=ϫV=׿wv)?2Ǎ'x%_1cO>#ivLD7ĒI$+1%l*Alfbݜb5+m*¬ cSuxLƜ0{sh.AY5s6SIsDش٤d92q8 $#9ckz9+W~o>?ryÆM6?sM9~k׮Z?l?kjn cI}7Ii;#-cH{E33J$ I(k~IWՋ31:gѧĴ ]F,s]eίsBGT?sݧrjŋo3kwyG?}=zg|bW\?Sri&Mϯm6׬Y|t'/^b .'!J4#߷[w穀uϏ~+Vqw?٥4{S<%o3^o<䉾QOa| l>O뮈W\}ܱ3֯}=[ )B$+ډm"̲e~ӟ l>eGgo{Z?c*u!JlF1t_R!ĘwJjSc?鴷NY8B%$S[7Qeƚ~[Gc$VJ[ܑY{ ;/(5ٍzia0'b[4]!i2oTo__ڻwyԔ)S֮]OqG R|;9']ZbQ$07H Jԑ&| OLM9ԛXM)sW5\38X{g.zgn~On?T*k1fE?aq>3IO=duw>xϯX?>?Oq᧝:{Ӧr3g ǿ[a<#׬#.|Æu~3Bʬx` _ϯZ^9}g~c+x~BdZ5c.A<$ŭ61Dh4Ԍ{E"m'"(Jwd$E1~&؁ rKgߐMGq[bkW*r*H$骝ڍT*=S>gW~ի7 \yŕ]E׬Yҥ7m]__??`03Qz`Hm?G!/kEzi}ciaNRVf͠X;b*֔m0)Ș8\ء0o-ȹ?2p# s6(rdfxرzj1cYJQ*y&LXr5O bˈoQeY`쏅SD0ҡH9qXH e6Ht $rMJ1z] VPneloaf{GJw?a8s~Ry=s<)^otϤo1c .JcO,W۳vͺ; >p?]zcA_Ɯ9tGjFmħ2I#ٜ)C ed%s.ƙAyBvhi<_ DRP@9?3pUc9 F.?~|g>kpp8^k#K> HaRF])ʆ!"0ل4y]s!fjiTeIltnDS f*JmB1=JmR 0[h 3?J^oJy+V'.RYC;/UJ(%fCI!A [5s̟]uuk|>O]+Boo??2kP{Rl6˥bM8r-Y~ l-]Qv }}@<ֲ_w}Ϝyu;/^)Svyڦ!Ձ:oUN82zaӥp("^B-REOϛ;sܘcfoOѳ?O^o{SO}ˎm4x7G %;{_E91OVaΗNme,e8|w.N:D _8.guUW]40aoO! )[KVVqBbprDF[,GWn9j%Z@ `,[;mwAh}PQfYd A [uSR&,Ąqcvu/}JP0٨X$!Bc<%քl[o+9nÇZIY7z{2u;_DtJX^\ )h=O!XOR~i`FmPՒZ[-岿njشaqrk{.\r8 )DP/,w[Aۧ|Y0wB%[w'L Z`έN8Ѩ/[t W_0Vfzm{p;v3Yf͝wΫ/{qMJ%栉P)Y  @! `˥ޞ_|ﾫ_|{/ZuR& $"̜93 '~/ ׯ_{{mVqN2ww9oJZn̡o708=o\A[޲~9sNnjZ);5WK)y'|R w>@ڍS?_ȕ锧s'T]uǓg_juu'>/-k:U7| B^[NRJ*;ur}E<|c>Z֭s;Xֺs#B^^%t4˝mUSB)v Nn1[w3γ]x5\*Əfꁁ͕Jiҥ4ex/Zk;f\))*yZքa`VXY*Rt;4Tc8^wݜn>}g98qP??@<?]v-޺T=O?̘1w}w@,<∫{G/8m!-Xp=agLtӍƍ{qAwXAh/wԆj_4qw?G9w'z-_:+Uh}ެ.\+tZ&/<|5̛wiػzGE]Ͽ>}T (  7o>C_xᅫ;3g?;e);Ӟ{MKoZvyU/]z%]~ {ɓn;!DR=0`R ew]zfՄ>޹p{!Ma0(phhaPoHg#%#54|/.)}9Xp U3HfƂer\1)Vyf3JfˀZT1`dTl A$-/O;Aa|{i_8(} d&dfmlf- HHE4"P[@ LTk(F[Dq@F1dÏ`!a/Z 6 $84IX :CH,҆IH$CԆ28l1uB0 1 dH,xs?$c4b˴_؉wF[$ Flil4y0 .0P1 PMP `cS=o``Gg`f.0HB El@t=0FgB(Ԁ>-Faţc7`9.]55:n'9ቓyV8"RlOOexG3"h=oF4בK5ʀ#uRz^%?k `^}B&K@,Bʋ2$eG^ 5qܩ-:cjZ3$#3mގ'lD+8FJX8 G dmu6?hL;i!#2R )-Ӻkݍ6;beYVD۸ #j%uR[DobESYW)?آPdL46koY1iƳ+oy}&lgZ9}kɒjl94kZ-bs!%6„\D-Cw&K2Ԛ B;Кpm`в|~!T(3 cIR.Z ef:5Pʗp𡙍b_0N~_$ r19@@ʀeg}6zDFH2{b#"f-y@j=7͊ll_k1Hdk@k!C7HptmHDS 2ۡD&$B"%!AtsUQ:(OqR*!TA ABm[fȸIizM@j w+d7,a2|hS˟#| -!\YNzW֖ſZLlU;MphmBM }͹M@Q!AqAj"T P  H@v&ၢZ5kQ%.g!(;\!(d. |-Ѵ}{~ 8[ `R+:+"Q^S- a4Jm ٹ?pAcGm =oOwq_-j#áj(Yl%zݩ2__7K480R`a5D~AQZu)K[_ju<4ӏ aHH 6A(A D !(Ҟ5_m˫ɀ=TI;-]o}_U>.EJϿ7".x2$B%Bp h4 Q@$8\J0E `R`aGČZ\kʿ\aANv'z7[ʰЂ;x "BPDw2\9431d )%Ȅ/8c6CFJywmȘ}R2,bC!yB!'Lm1)Q|Fpf @k#wH/Q !P0. ~ 8q[F7 hP H"B_T P! @@AHƐ@"@cDeIF9M ^L!J2C|-Q 2mq)}&F[JMJIl!@0$ HzFJ#gy<BDR 6~5CdB6Bc/$2@lx!4hR*Uy{u &x 0@:e[@DBCZxRvj7B 0Ezo{?b   <R}m I%9 t=OY2 $!;O]ϕRѴ7 Y"2h @c8O-g)Kk-t;}ۀbH ! B P Bk{Jy iߐ'QJ)o<ҵ"ȐB5 4,N7`s BPKm%iMZ((1v[* p\U!k)i,eH i\ӞA+{n@B= ) TJ% Dm|)#P5CG4yQ)ik"pC`osQK26lABI@:N@@ |4n?aP=hRiߑJ&`!OF`Y)YBNw({X4K:N4QYJWk΅8!n$ZkiǃRRCC6E_@DP@׀!0 @ZK! o1.RڑBr }^(ҳk_DT}_A>'@DZ{B DCFoܴOޱ_Bo!}O-!0DDv-"Z27js؁eu@B zGH)ɤTR)g1ZTRH6 `3 @;"D"}CAHc eY|O Ttl$ '/D C4I˲cxA( H 6|߲ls@8tIJ@@2>S \`OT,A}*HDl+t!uMT@HrQi@ƸTNNL +dԒF,'&15t4Z[Vu9h2?F55%^NNT)e*q@djgDa٤N~B|n $s=@:>J!:t(0|c8ek)d"yI۶hJ#}낯XU;ǰu`xI"$H{Na]9OjB߾Ak- )6ZКwb $BhcH ҞvG~wչ2*Fc _KwF %$ TP8a,gݻ$!0L$PfȤv,xZk%1J!Y1 T8BrJ)m4׹i$@@[ ܳ y{Uک&@I}F/P)͜_V9fE$o ;8@@"5*iϟ?G ?{ϥ&u|b[vlcoݲ%8?򪫯Z}۶(|M(7WZkN|DRh,Se՝FIY_omԩ_ݩS'c`Ӧ>hco`I-TVi$D29nO?|2 Q  о!08W=$#@;GAvJ; o9穧|)^D嗷rK4B)Os&'zR>[쌙M&!O>$2B) -(9c)oRRH"V"DFdIvOd?;WA~x']ϫ7c/k>G=}|5^3q7'7F|lRJ JJ|51F.VQ u@@ ER"ej@ -}z|r d=.??RjϞ=%%RVQRRՎL&mnjjJ:zۺuK֊;4D.ƶVnYlI'IJ>LܹS!,вx566ڶ8N}}}aAaaB@+X'}ѐNj~hó ܆|7?7빿d6T<4?{c (j"C=>޽{oXN쪫}u{%"u}oll,**x<^[[+,--ecu]fX,&oɩS#P'≽u{srr:w $7tݻnjȠ@"?{w^3p .`]&OQ6lpgN!N;։D:Obђ6A*٩S')vƜܜU;yٳ'H^ )dwxw}׺u6mh@sVƆ=53K,} /0a¦M&O,;9Pkjj8ƍﾳ>>o[YYoѽ{GK/͙3 r5ضG555ڵ_~;nʕL8qС!C$4Yf[__nݺ}{guٳn:z+B)uɓ'8q '/[oաC>}(% 'Mtw.X୷jjj*,,[KKK_z5ktqݺuhb>x/>6Ȅf#f \ &YFR%[_O(4ڶ 2D"u˖{??@c4='7.""˗?X3?_2444}Æ ?~RjΜ9sνğʦcǎݵk… z-u|uc}h4u^z]|O>d]]]Ν#8S ~e=0`Z]WTTDSOevp~E"7N8G-++,_tc=&Bw޽{EEo_\vew^SS7|Ǿ?O k?sss%7-O"K l7Z7QIŬȥA믿+y$d,+//fs_k]^^yމ'7bĈUVu֝n+bȑO2es I'7 [Ӌ/0ac=gϞ=`oW^h4ʴa)P]]]^^~ '| ,hhhRΞ={ʕӦM,?~޽{.l̙]w]wݵsNqxm6uKKK#8V"~3ϼaÆ=-Zh޼y=،36m׿niӦusNNXbȑSN=zd2>!,˪7o̙3'Noի|3}={|MT]]ݧ~zL:sSN۶zju)-s1pd<6_l׹* 8<*\[x<0ƔѣRJkD|ߏdbƌzC={n&"CUUU"BXUTTTSSy^<=fϞ8N";wm~t3s=ӦM+//ݻ̙3|ٲeڵ~wϙ3bڴi^{mHF뺎㸮۷o;l!y`ٺuk^^"HΝ]sdzٲe |f:s.dڴiwy?{UVm޼y̙guɓGsϝ}َXEDs7J'=43oҾ(өb#2'KF=\-ki,**z:ucg\׽'Ns%I9!D\mjj,+tҥR*D:vد_^zd2[o}uuuwu9Ϗ7[nB !gوb1 R)ǾMFM<Quᢋ. Rq=z}ر`Z#<*L&?;f̘h4;vXhQeeٳ? 6رcʕ'tRqqq^^ }v5Jn׮]eYݻwӧc]~}CCw^cLWv > -!B^yFQ9  mZ?SNOֺpwyUW]o~zc8D,SJL9rduu_~YSSS^^~g{dɒƗ^z?nhhظqcݏ9D"***ھ}{$1Ɯ;wfgBDzJǀeYRJ6ԸQ, y7|sȑH$|?H$d!D4=>{.Y۸qcMMƍ_xm۶^Zk=bĈ.]xWRR8NuuuNNNǎ/BÐ!C^s疖rd:y80L:KS3Zri e5u+l]1cxׯ_g}vĉǏ_dɽޫ4hРAyW^yW^Y~m,RcƌYrݻW\m6o޼cǎ^xaƍÇݻy]vBd,/&"uhѢs疕u%|-7O>}> 1x]kD"๹rL&.\8p#8O?mll\pK/{O>1czשSZwᬳbׯo4(??5tm}i0a68@e&-SqYW,fb6sѨmۈf뺈XWWt#Gy[z999z[ ,̙ӥK־EEEoȑ# 2k֬۷/[LJ٫We˖SPP0iҤ;RjXp+"J))%"c#я~Էo_"*//'6oܳgO[" LUC< #H)xo@N4#عsg(,,%t]=0-zĊ+?tek6+"z(䒬lI+]TA*dFDOBm]yVt,G<~v%lٲ裏frض]WW!^z>|xiiinjkky:dk*x7^u-[vJ4SN{ov;NZW)y̙;OǏz'x{aÔܕf}ȑUUU+VXtiֱcd2ɶII]wy֬YL&Y9K/%nSO;XAf%RjM itOo++C3L:fpWF ,qlm0޺uym&Loz˶?|ACCCAAA.]rssY!CYt͛G٥KUVyhll|?Cq|ߏbd2я~${ r}`bU8!DAA-Ž/zĉ„O{`9⎥͘1cn 6,Y?eYMMMq?x6vcرe9Ò;|ꩧkvܸqNܒa 3^k&Z(B$!G`{5{J:tD@Vu%%%7ndn(Y(Gyyy~XsLjN+PS|ݺueqRʂ{oƍK,͝4iRNOW\\s)qFdcܹ3v֍}^Z_{_|qw5nܸ~㏟>}rDdI&|UQ(A~$1OڗL&Y3C!Njv[}sFl 88k3.ғ)F ӗy"GĜ;w  .I&-[N%a<1cƫꫯ &ۋZhڶ}駟uY_o1l0OymLhrI& />eʔX, 0{CCCΝǎgq/\^^OcufY֩ڧO7pC=LR[[Rf\Ƚ%%%'N7n܏׏1{Ȉͪxjm?e|oVچkX[hmQQK*^ȕ }`F1mB0c}Ƙ?shsy+++ncѣ ,˺|ߟ:u={.fiqY]]zs_dɒs=BGDqh43TVV.Z護bS?@tЁ>㪪*f2?O><"n޼9??˖-m۶ɓ'رwާr#?uGO>r3gZ޽_g ?]<uڕ P-YmȦ2>[_L_ƵfUw_vرk.Qu/^K/-**ڼyW\kʊ5k38q9s\}{9/|ꩧFշo_U)eNNΨQfϞ=bĈ2D=zt~~>yo뺹MMMׯ?뺮ijfΆxO>ݻ7;QөAvt ɗv3yٕݽ7y6B*NUu(./FC;~.]uQHĶc9߻w^z.駟^^^xb8㌼}>cwo޼'?I>};wbqQQѨQ|իW/gWJ5o޼+wZ3K xÜ y5;y|P0# (eY̋n p~]?? z Q/ͯC YHLy1>s $VcǎK.2&PeB4P+WH֛ok<o[Gjk ȶrra2v(µkW8l0fof?VO)()|b3*Kv}D;xuWwobvF +%ֺ+~7j(żĮEc`s6 d2OTUUs=mK!ѤR\!R/H p)cW* 1<#z޼y=k/<|GJ&{ܟ shP*neWB@ 8,Pض+cZ=!l5DE@"",e`9L'`@m4+imm[ƇTJQ#͒]IIR!DWWSN]D<W]uuCF%&4DhD'p³=e˖#8yBH>maӾF Jm*݅|Z7:e[٬N%5d,"CyZ),KARIq!c JJO,^4`#Vj~$ueiߑnz7|lԭ :uF1,kիԡ1yDWN: ⭬Z9n=?ҐyY H-,ҶɃ+hL/K=aaX^,D,F&b4e$1:Y޴ Hjb$EE%@DzױB4ci)"#BDlFr&ui_ÔoСJ u^ tW'"<^UT7Yc g~IwnE5ةcg!hf F[R} !n-N!(%0DD( nD(h}-mJꛁAo8 468`Lf6`&ľη7l{(/]@(B$Tl0*&L@J9L@a4} 0Q SdxS %`! D@Eh9OjM4 SOipa8 aƄ_Xٔ4&Elm}sLF" !H`@<a8 0H #$ _#Zk{ Q>{_84 AA۱Ara8 0q."AB)%۹1,H7%mv(IA:a8 0qgRD_I` JVH)0dQF+L 7_D; '[vc_@a< BiOQLt 1@>9ĮeiCDL )wvl}h֚UpB)8[h @2T%P9"ڷ,k?1H!F@(јvcP>Qfb.q!a˱I)cY֚#a@ăj=sQu7B(tJ)`@{>(IG´2ҡ}I$i㠶H?mIk[rO[s@@@hAWGSi|HXg;̸_a -YȠ& ۖ]_؎(Kq3q/$a4Rȴz)TMP/ɳ?m@AFsx+"Qj)Њ8D8ݷٲ>.jYi9iF kF *H; @RʈT@|_=#"}cY0;Ggollm%r]Ok 01 ,3%BpRy~?־eI]C>6[55ŕR`#Dz(zY15,ZP$I$5J?5W9/SF@ :."Ǜ(j}HܤiY"~o2Kr^jfv`Lm|o2QU|G!r]7L@9KIɶD"%];)B%ֆZSD"V" \z]fV_Ҩp0U e11Hy:*HOT"nBj"f* 8h4J#|LL~<+,̳,/\ņZD"RMP)CV7oͱ)Hr8ebFqy"L5Eh-/࣐u3,VHԂ!A3rni(3!3Y¬ bឥVךg"66oKҞ=JΈIb۶?_nx!b ql;HE )7%Gd!=֩RMMMumd2# udxƘMMI\s*XkNE1] ;D\aPk_HᙆRN "iW Nd4!'ERh׮u\WYV߾}rrr R_yسg>}z54Y;Z0dh1${KHDY$^-7D o`s/xRI𪪬N%=HeTDT蠨(k/36TF4B $$sv~{Pyos<7^묽ګ|ŤI>hocAsŊ}_sϽK`zQHC 1F@PSgk dv)m1R!mdg9ک%mv<2gδۧ74"{6IRڊS˴:o%mu V'T6[)E4K%p3!紘O]}Yl):=k y#I[(e<=ʔڼUJvO>9|Ï~fUUKBd!,$d>;B-rƤc2sƀB .8ctv-fgPVhPb8)9g6mR%3 ̶@PjFBpMɌQE#Og>A9T#\Bpߏyޖ[:ۣbbmIXcQ(^)QQn+j=>?5wVV.K";vC ;:xy>}R Bd2>}ZK|{~qs8TU%B͍ǎbi5 !eYE%>oGO65OLJ1MCU TU,\{`sܤܜ.$9)#vrΊ1MS[lSU]Jr<&6`>)Aaqi#GjJ#PS]PRZjxcMv'7'*,,R4]Sy)ssj9`̲ WYYr: J%B~OA bڎ6+YY donKuRB΅:tUI$HMv*|CHv1%ItiCB FL".xΨ0sd -=pj7s 0V6ޯ OL[QyvΠA,:;*BEUQ,=X]C u4UaNK@AB4v8\EN5W_CU4g0֋JySQ+*..!v%)%MJkk뱣uB~5MWb .@FFFl\#ǚNgC!M [ZZj^@C$.쵖 H ҈afN Mva T "SOݮ"tƧ}t=c$o޴y_,h8?oqr[ϧLIQ`hm9p8U0f-,p◔a9ojlt:MMG0k:P!i,! >8w)huuiHCmn>z31Mǎ=tGANy_>ˑ[NpG<xhCC]fffVV"(^0%NCig= kaee!"!đ'Ӟ;oXɥA֮]_.=^|@UVfFEﺻY@JZfuyy`*wT̂^[voٲ9>!1* 1ABaq)uݺ^}SO4h 7LZjM=?mvΚuoSS+/b~Uӗ/k}7oߜ˘kyܜõ .t:]ݶ}=ΰa7{ l^~5 s{j~عsF6ry#F@W{Q.W[{ۃ>;=r>D~KJJfqgn޴oU7xߜ?;w9曧1cZY٠بõ Iz! B.`ê?xW6߶}W^Pv6i.,*_Ud qD;_[T\'AO>}Ec'N?TS8߸qÍ72,\$r. ;n4,Rc;457K~ڲ`S-\B~r㱱Bʿ7\ݳsg{!%%O?vׅE%Q>B^TU1reLMDu7Nr3 t j9?eڱ/BzZǰiӦ/ =^;^yma|\;]Q7';Db+)*`λ9;bMOz\0XNْ]#v `$!4N:-]=@hSQH5c 1BJӦM9c:eB|ۮꊆc/33CU}p}>l۶nY3TtinnvuuMi3f8p`?|p/vS y/xfȠL+<++Gu[~%r;Wmeuu8W^` |>߼'{뮽" /{= [nٲK VT8pi;wشis﩮9ȹSn3fѣG__fqaQ\qŕyy. 橨|"ǾOٍYmLQa-H{! 4\) ![9dП6tqR?˨QnuG}_ qv=3IIɋ/()-;Q3I|Bºfֶ oykBb TUryDwo !jn~֭[*]>} UUofSSˁ*+_yeXmmݰq:!9I)ɽf~hsχ.3OΓRXW_y_EqQу:\[4EVU=<1 O)kljJNI,(3L+>!awU쭸[G_x\p}.RfuΜ9y_|G/uΧz򪫮AQ& T=65H,UƈEy睗csvsONN֝wݻJJK>}9szKkfl.|W|;n4a ă t8HVv˸9jԅo,]_0TU XgߝN/;]s$3ϰ$b{0H;I]֭[{ bh8p NMM%AE!_qCpMܜ- <4)׋/Tگ,Ӛy]ׯ7qƦ??Θ19sFZjk=rgHz"ᶖ|w \TX`ε@i^4v1(c͏kGE[ <)x(J0h0ƶp;[ze/xJtM[|'_~2 !=~[qe #X^^&C ɓw۷=#/,;;355Wb±Ʀ[Z__WZڏ2r裪'zNnp PUMB auuG\Ce"DH.rNOD` }|Jkر7>;;; Wh Xuj}O>@Ӵʊ EӤI LLIMz=M-kԔdct\0 꺮* hY-fgg|phy}AC-SJi{g457 80~xUU ++;̳-y[t:cΌ~衇.#GPo&!v! &)++s^_մ`0X]]k玗_yp?~ !+)2TmmQn A^^> )),7MqZߖeegee3F8).iyӦF˴NojjjJH߿Ԥq{CYl\Rt)eZz<9v9\޽3ŔqJܲ,ι\ g9˝-%%t:A#O6E߰G,k玭(uu =w8(*:az C>qž)ׯW!Q߾6mڌrs"/!!=uuuw1B*cLT0eeeI6nҪn5LcTp8]x}> h>~Hj`08jԨ8JYii <9 EEE!ECX{5.H܃sBȡCV^}}*D2TMwtxUؘgOy}]mc㱤$]w@HK5W%$N0ĉm۶ڰx{G{aQ9"|>8 N?^w8Ak!|c>rUPP@-fӱUI^G_S] $D Dh9.Yზe1zu {w#+J׹GI\p9Ec.zdC=6kʌ `pVgf5 ?aVlea)+*:kkmiQ!4 B0cT!*J RbY{ABHLQЦM?xQKI#猦$<*2dDRs*>  CP .ǍdɒoOFEE`aQgYׯBC])S]S )ea@H[.`GGE1[9). Hi;K1F0,Cp @gee2.0E1Bp!8L8!Q6Btx: QλB;fNKܰaz.!DԢsjʕ?X  B0Cz %#*JRoRBoRS0uMqC5Um.PbbO?m]Q!5>xvZ[vlrꙙYNSJv;Ͽ+WXf 9))99U K "%-EQ0` B1 H@0KzGy뮟4iղK?}+ BHJ_l=\]Ur|ܜl!̛fLxǟxbޫ'@^E?}~~b˥j?$@o5>ױcG}ݦ&a\SJ-&h?x7x F9 >۷[zecƌJ zN^;5M+sssWBbr}}oh7m0 `A$Bմ/Z%K[Z_4)yysH [m$ N !@ kV؋ƬZ²=KJZ8qO{{ZZzRYQh`P#7&-\;HNN9595`Me)  85j߾K&SP N-ycnj~g.F(sKI%%*Pp$<#=b.HCCRBBb|,AW_SPW!U*X2pLdסU)'1@ cR誂 qٙiŦ$'eDEE3j<3cǎYO HA`(㖡34>! `$8U` A@*I]H <999 In3)!2 #PWzA `,8kin\ɓ&=ܳ: IN RA FJvJΠE (3XzzԩNpF`3KUiP<|Nv (&S H~}AJF>w4ܾu-?{@J(CW%g{s vlGP0% W^>qرm-'[7; $g!T/}Auu{3tXSOL?r"7;;%9%595ZjM_xٹ=:p`rg@ fZi))yxQ۷ GR"(HJ}%9- F4>Oˉf#yڌQ2Mog459yǛ-pf!(/x͛?T5-==33#3&:.&W_VUVdcӯ_iS5A`ZI~eR1RFA@P.nzsA߼Ǜ[N6;B0N ^tц U v98)dZzFRRrtt O>y=K,~r޼ ۮԡi@(,';'̬ܷ~g!% " PОL@"Hpdk'LRRSWIFf?\woBBի23)coOḫ]g9rTKKKZZUW]EQ JJJV\Gv*}ѣ-Z{Qv;ow8qbǎmsMHEA>|ʕAصkE)B(*}׬tok'L`KRB*lf̅fͺ+u]ꪫ _x555eB1Z}!*FRk>(0 i>Fb>"^>xb^nN֑]

YU>zqׁ^O?+srrlb4t]ڱc_n~`0Fu34ƍ7x>޶(=\\\,$0MS5[bŊmڴi# bp(eee~: )Pɍ7p_ve/ ֬;T"P1:t`U!#F`LDGGϙ3g…G`}IIW_}>|A]9sߧ:w=vH||bC]w]kk}WZR2A0qD;jDn{HRs6zoeG8WQHJjԩS,Y`pM<_~֯wkk>9(y@b=( bWSC(p?W5]yH7dgn+?.6 F 0,k ْE<3~+¢t֟Ŝ.NR6?oCyyNqƍ.rƶonD4 SkkNgFfoOgrWзd.6-zw3֭]dEAjZzqQi'NطRJYXX1ڴiСÂ@Ձ>/:&_~M(,>[pk22zƙgϞM({-(ymnQ2x eƆ 념}i9RPPꞽ}cc عsgaN>mɗL"uZ]zƬ\)Eõ))%RJc׮R~MI Uǧhi$mim#PViaU0 A/zٳgcGrN&#v=SSs"~]cι 篺p$$$8{rrhi9Q.Xvvvvv.@Q!E0|wWâŋ].'BXӴC>|2=iEfgg?~<4 B~@'RSS8s̼喛1! QL"SJ!R]JJJ]N! `QJ_~pH)u۷c|˴*;|\Qդd]22kTgeF۶mPJJ.,,M:͑$vG\(>-^:g,NTH.Bp(AJteezzz\l֞=SRӲ}>-Ғ,Bw8ܶK0BVVko;;#3Qb_wG$)ۻwa23O̘9cc.r.)I|U5!B0]w`3eAw755ڿBB/ -[(eGG$$$TT+)3?zy _~ɓ)e;Z.c! `L p:tBȆPUi1 v!_Q!?Pp%@Q((iѤ^qoV[z#Ba q!9 ĸE(Ä@ "a$BA1QrUUBiʹ1&iaEB/KМG"BJX!I.30 ~B:QU!PB(""dB@cb= *..b)c9HBeQE( !L9WT ɘ@Qa9DB8P!B'wBƘ;XQq퐾@(Ę@$".%& ɹPTq.I!œ VT.8&$4!\HĴqI-UYU]]soB$ iGRB;DR E 2-*e\QI"DB. Q]jɓ!q .aWJTM ::K.镔BX1kZ4]B,TMB5q5)>!&- !aLAE!<"%\@dQaӲB /G߿GB B"DE1- N)#ƆiUU%P.㝻T!НiQLR!!P4ʄiZ(AÀA0fffx<" @D5"$1B )L!L)Gl޼ĉws! Q6 DE +4mt !#D BA$abB2 SQ*N.@յɱ:\WM @ ;C H! %fk# zj sǠ j3G8`DG$0(CQu>4uS{ㅣvG%@-H l3:t(ŭrq;HQ B0IE+C{pX2&sE)ud~ņEBvV茬z6]ιEkWn C6 F`2]f8q^"zABrfEg%_؃~"VnBtt.)i)/A)!z]$g$3AH A]!z=aPv45LTRN>#|MlNd.6l0/p !8(oWo+ˍ%B !gH  rm.ϥuHuaiaHF^pNmv[Caw))DݾOrg0<ݶ;> endobj 89 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig2.jpg) >> endobj 90 0 obj << /Type /Annot /Subtype /Link /A 91 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 333.5715 260.2500 492.5715 ] >> endobj 91 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig3.jpg) >> endobj 92 0 obj << /Type /XObject /Subtype /Image /Width 600 /Height 205 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 600 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 541>> stream xA 0 =" ʝ<2;EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$Eb(O endstream endobj 93 0 obj << /Type /XObject /Subtype /Image /Width 600 /Height 205 /SMask 92 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 600 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 85894>> stream xy&Eu7|NUu;wUE(IFq(F$L5&AQ# "0603w<]UꜪ~$~qZJ B"T ΀03t'L~1:bXFulD5׳DVT("LjP]utW)L&[ @)Du]/ƌm"d0\aԅPL'I$!xVΉ"$:109$B1%8Xc az3!3gn\ug 3.;BTd `Q@2Rg4%sr|rA+ Hq % ADqdq;1%F3̋R6q$5(OVSD _nJZeY͜KN`b$ 'uʷDq$y1q4+M],b%HB)} qf)j12{U t7Ȇϼ.q|ģ!&R#8U]9BWt uiͧ!e ]!r`+͞W/ ]#c6|؝"cn9jR"O(,bD@{7⼼e樚1 A\Q8p&Gc8ϵ$a40G#(J@"$ct='tk@&\ Ζ|q:_KvEPJV D#;1Q`lFee D!5&v!-*#:gN @E_95ӓDJWɺh1)#2f #7t,KXG +D^l(ba$K$jNjI.:!kIA):` ,x!̒tl?@R! YJY8A#W4[ Bl]FXIyb),}P@W1Bp<$@O"*Qր9hy@7,I8a.k#cS&hf+' . $3Œdw0tHACÔiq~ø8p6_@Xx V>qύBAC7"1"eO#KlȮB2hJdԙ%R:Ht" Bv񎐐 U|X4 d#1W>*˜څ xI1 M#aH#)Np _(xq'扰3ىq*y1pbL|l!Kb.D8J? 6,( l=SFq|qP#`U"d9K)ӌP5k0 ?ȋIiF$U^'/J !IBbIHn!W.3U#(8فt+I 40܅`2 @?nydIQB{bK2*-X~ ;Er 7rG&`OvSt1׳55(T["!g3.1"%QƤ,>LEDW92xL]#%{QYKd(p5-%$iȤh=Xq)҉LncBO6bc渆g+O?)Q!eKPFZ ,! 3Фlb)l޸e0$ٙaE$Ob}3`V̱L*e !s|J=?f=6qPDy.im{ߎ} ,BgR?Ƹ^ ^OkvW^ĸX?_3)=QX'uIj;]/%yj'qq3ƒ}O %QNAcdȄRW&d͢ KzJro# \\{!e|e7G1d--3FXwŔ_Rk9l"1Jvx(u8V/7\eT3k`7L,qxIiOh1y^ESW%.@>y RtPQ0jnzFi>@ii:0JJR:VLXA#9s4X|{ǓS,LCS׀.VAn\ِ`Җʴx%VKtγY{Q-1a LQV)2u1:I*r#q3/bEyf  A[=3}ȁ{'m bP72PmL }]r5ZQyDRM+BvCp%`VP':Ulȋ[2DW rDV*MmItߓ Pb$ln|FZKr$(x@,l;Z158ݕoްmyuo̧ O=\_1ന"DeRF`Ag^ ?2_^t7hf\NwGb4@ Lr+#<A6Hp$Od"xm\JMbvPE%/W)ːHrW̿rϣqOܥ#egOS䔀{< HE;sR슇?C-|!݈줹l͎PKz*W&tԤ?b-Ló\f]r#3&$+JUQPZFˁECc/05<_=O^ӌ\S}oHkMMVgp=6_&^'rofN~.a, 8dec?:&D."ؒwKxMc{% @ TTTIoq -*WzŐHVEŲѱKB@6̑-9(q_m kd>#O:3K 1;NAdθOBrhlxoQa(Z9q,IβN $]D㌉<8d%8d:Kܔno&ҌT)$;3D&j&m J1N0[PUsF?)oag DYp( I3 N#]y͛mͳ8gw͍{ܞM[xU?-nҎ7Av[gͣ5?keg{~kV\\Xw=[@OYC"'`NpYdI{uxK!E,'jQ1k>r_> ¼+\E;Y`*~sE$x=HƞEx*9^JqJQ'7I?A =Arp?ʕ_s&ڕ7<}.vYg[~pkw]q􁧟xkUn_wkUžO' zEӨůpݺO:_9i=Qk~[~ǓNtMd#2HY氃 G8).Ed rv3čBi9"fc)tZvށ{ח@1k=JtW_y?m[[:Y3{#sוNB@EKOp'WI] ܷ!zO=f`>ΆYTGx!0h?xabFGf# SQ'cD+J0;rRTS.א$sLbŤ{ʩ!?728guaV-h8ejH$~1! -/COi/RQ2,.KNB giR8W:tL Q@ND;d#b# |] iIBPhTޕ*eqUhr5&@HִP8vꭿڵw~=cdEHY斖2LLQL( a1;`Z'lj[x.$ǫ(d| 4"E^A;=,Qv85Mm;u [Zl>h8sb^ArK"ĘOejb G ~rr"hUT`K6k%e;\RVAȚƐH_IN$H ! ] vݐ2*L8"0y?[$Ǜ&ݢ !`sXMKr>Ʉ# t, RLۧ.`%NddDak+I]@V0\'[8'Smt 7}I5X;fyG^؛J48BWTw1 XVY\@ՃzOM_X)ZGژh۶λ߰&m-s#뽁ŖeDq40#@AS/MێbQKYڵ(l #tQՖ"cK\kNg_g W9 ab{t)5%D]'#Z|•((1ёx weҡ8 [ r WAkP`aUgWD]{֭6и;:#KܫeqIlD)ސ:dq&sVO>1!*% Y #̑h~> {< АP~#N,ʠ :&񜓶z󓱣8D>A>+cx,9[M sZ anŹDH+)s;I.Q39ϣ'Y3!Ʈc|r $&3dHq%3/&_#3 /94TrB&;z _34 N1R2QwFDIDDP~zCwV7l?mׯpMcuU[GמO>X4;mqm&3;җi'3DW^yYhL+Uv~_UM]m݊Z?`? A~Ls /3v9i#1%l؁20ȧ0m2($BK"%>:9el"D*0.'4-hTiGs sC3r?WSe'̑+0fͬtF.0\WiÎnr_^ِEt^G %QoK==h{KOth%ivz]rֲL\ڎKv.aN̦~% iB=4`F^?n\K^RiiGY[z ^~jnu+ցB+ƣ#V^.R+FP ,6 u6h+Q[f\hıiu5a-\Wx]U- =S/ uCL?x" = 'mD.wM;U I.ҖyY lw ( ƭ"D01vֶP87?ePe彃xTE#XD'nYU,!\2G/WgA-@.~7\";aZdQ9@ DTX9[{d=Tj*CFlYohlkQ ʓDF'En#s4xj 8mS+m z[Q`Ѓm_0s6-ʴQ |~IY;m#UGPeZB 'hL4?zlEr烇mc6ZA H) MqE)W~VI?p9v_#ٖT'?& Ă  5VRz2zUz*޷*1QY( -m<9( oJ[pi7 U?]_@Ldێ#; C,jPD Ҡ?#T Oh"Vr͆0 ;_N>qQm; z<=-ms[n#NJY z#ܙU~7B!m}=}Coos{$r(Q[MNG5w?*}/ʖ|!*݋%MD;GtΝm{[ŨCEVGp<*k fwY9]""5:\[t 7ypo;?JhMs۹=mٟFVA|!xD)-#jSj:1N)H>B@Penع-vBp/4ܵtk)`Q*arFNߎgڤˇoCҭY;Jp,9,sr5($af^Y3a%:J5iOhHGCAϨHB"B%U{=,H!򳜉="yFܧ^) D?RJyqy:HR#HrO顮J0DWι,s=d8TKywlmO'ȍXC <\ G@iE@1C?}#HJmTO=xP)P=iUU RXD;#OFimkZݦiP)"mlS)B-Y )@6 "}vDd1.,H+zvY뀀BcLQvAx4D2Fx{HD>Gڢ0?5 ,ٹ6P;/FD`֗eւQF"4wkD>P)::ۺQZ) 1P3 mֹP֬MykmaBֶD9[(sijk[k[P[kIGrGhJDd!zE>C!#8k\a CZ뺮۶m۶hh6Fc c\Pkv<:_S"z%"x07MkGsss`DT~/S$>ZkcFQ4eYx[xGY9l]~~~7M3m1m*7(\W:ܹoGeY/Z[Z[׵wQ9犢Fm.JT'EY{6"j<@ke.˲( '(Z[U="baa~aa(J`ЇXŶmeY!!#TXkpMywޓ'ij"ǣiBh%]]ж"`02FDQmz_Uѡ&b(dA^FDn6Ƅ_U?Ry5kǡps@mk{ 3Z˼R1@~=,ą 꺮m-ywpnEeaGԬC. k[τeyFI|nN?<EE<<ߤ̒7(AT^ƌDR@x'g5UjF~ utf9|a-83*Yq%Ñ(^v("ʻ_Qv/4‹V1bImۮ\1*ӫ*xC&¸"YPkb% oG~)riNy0  LzuKm3Uaz _{҇0޻|[~t ݲ,uZmC, Ӷ`]EQ}_>~zR}x]"jUJ!_|{ԋoyw‰/{1ߌ=A6!v駎-"jR/[^O^p{Q:k]vL5C|׻O:G}1oo־mR0f]Ow aD)8!|yidWBubSʸ8S| jdA}?8"FJ%vw K_;! =&gEQj7n/xm2;}uZwܽ*._SJ;ۺ>Sr‰'zʓun|=D:?oÄ#!pfRǞR7)zaK6oI$>Ȼ1;"0, ye&m}[/=~w~F]wugLc.7qʕwm Q]_p|ӫz}/]'xxjj4LSITP)_ऑQSX6?4ǴISڅ9`(UFք|9& Bo5P<&MXs+G#NDQt># q{9Quz}\{E?\3TM0ZW}gگ'"b8=y77;+f镫[ BYá88v^>1KbfUy-S2}a3Ir]8di@f2|(ޮ{[^0=b=} 7Ph)z|u=~.+F O9<7R0R<Wuͮ{|a_ek׮=ϸ[>mݺuzfo w?p#x/%_x}OGgJWm~/~sy~}u?X/}l[Zk]w{9y\r 7ܰnk+?ϐk'} ^uUOMZ_?|;~]wuu]?I|-Ї O9=y~;s_xu^sϯ^~9 ^ R|/^v)_9Ӂ#:檫gÆN?=o{z.SO{곟|7_/[3uL!CS9N;knB ŨK9L]64i8.ndY!q/hj/yV'@1yVַPQR'_4>Oxz,of4zV׾ֶ/ijz=mg> /Ck}tI䧎8∪RCdyrnW&)%t#EV- BIm;j(TSd'Oʜ-Hlr,LLQRN`<,@g(Jk[./:y֢RFthOP)[n馷/Q]/}^= Fvw!*aVBdqNT\2@2]L- ˥aOB\2 l-2l*7!Rvwν:Ǿ-oލozӛwO>I{UW_7pʫf8O^[v} QivY[Y9ڴiӺu?`'׽y9䐲4Vz?|[|]׾mosѸy㟾_ʅ^O|O:I\VpV RS7p_]r_?=ꫯo:n_9i(?Oo+_=yg{%_֭[ްozƍ]W5\7|;_Ep^#xnvM\+?.:Eמw?mo _Wkkwl޺n> LEnW[K-)8c/q!!9hŋx̹CiRC'tŪlj"'s'vJAStGx2^egJ x:L ֺWfV ^,Jh\}6>Ox`8*زe?cysgffڶ"Ѡ?w}i˲46,DJƹM!EQc'\.ե vFDWm b'r p<ʲ'AaSd)%(!t'2d[FA4#9-)t70ǽ^VkUo{+\|UU5M]x<^\η]/fN>33ֹ-[Yp8غu҅Ro]jf|X%kbFKOdۉ!Gfwff@ )aAw%E-=99p̪ tQ զMlܸxӟzƿ|v4MYO|BU>q}pqavM7}Yg=h?񚫯]j'Zh<=xvK/pa\Yz춛n(Yg5=cMweeDÏ(|:ȃ>dUGyT]7|n;~|GzSN;G wdJk]rQGZk5Mkvu׳u֪5z)֭;ㆃxȮ{uÍ?\]RO;W}xA[w 'PeUnZgM>t!s$+aBPhK9@"H dqhs,#L9RF,,f6:noh1nG 0pnJEDzM~mu}ۏn~ްbz㽻6np'}ǝp¥^zGX~}]J,K])eHAiwb)\&"Dݖb))'`bZ- tN%ZyeG·:.'ay@k]_0F۶Zχ5}m蓟e_g}V^+k6=6MagsëWe|׻vm ;C~R, ?J=1߄!3k`W}yRQFik&_(icfggwkzyq=.g^+hA;7X 7wso{}~K_:;{VX+8] xMՓ|We,TU(<(L5ܼSf~nSԠ?`8׷n]X8;_bŊAH#(T9u6;JEe[[BP9ܠ޹UEm|߻+G{66Q4Ma y:755U׍e4*˪N?W'>񤗼}Wr {ò^ϗH.y$=e=,mT=x4^1=EDhc#@x-_}fGs_veOx=Цi۶y쳟?~Z^(p֚; ;a;؎ B|ɰv0wy*pBԋp0U"{zG{/zQG>Gk3+ԡz!{'vq.r%p7Cpk"y_%,1sFܶ۶.Lv]8gkBG?z嗟Dok+mo=9)޻9ue5Z\Ckgw1o6o-oQCrF`_ٿrs(˦o6ȶ]e48[ǥζ,ymtpF׿˲Q@@mkBkh$E@@H\[YZԈHm=S|K>. ._ok[Z$$m]Z/*5zgUٿ~[|3|+vnM=~҅ȡjںԸ8DeQ=_\{w?ֵvu\uq~h]SLOw Z뛦7UhӶ|Mܖl@RmLQ9W](6^U' :GWEQ]FzÆ k/_{GH+m%*ERF@{N  jH!gf,X( kk}WFz돮g-[7;D\@xWYCY֊j$g{~k[ \߽SO쐃(=/s@ue@@y5o01PO? wm7fR=_s>ȩ~[o6ga 'T:Qϝ7wg͞3LؿN;yEcf;̌QJHovR瞽=IlsOZ]ves+f̘1wKn~l6+7lذl}ۯZhk~;:n8wGE.[{*ѵZmڴ #thb!@ 5ZkDґBP AXRz($ {B(k@`!A%Z`-AYGSʚƭ |=M7P#ɡVz y@ AahFdFADk HDFAJDK#֢<(o4sH+DA5!Y)dB)l_'W_ve3z{{F%I)gBi?*a+A@ uVKϋ" 5¾Z}K/cfB(51"DF&!30<)&o~B  RBIxɺ;k RC!Ea@ߓahzz{hhL<~7MT6S" yJ );FB $A;>  {L% eRkEH UMZ% yzR[BzRy}D Ri) @(PRl-*?}zS 6V _&TYcRhmT( F#2FW*@iSRI6lm m=R UzOdQ(`!!=1B("7j&$ %_}uPQz+X =VXFd!Apd%RD*hKkk}Ƹq}CZҍmEl+;dvMR6J_v![M*ZN:=@;k:@Z% 0P[ dPy!JPGL hjmppLd--dթ^.~ L̩;)t'c@NrrLP]d^*.w“+kTDF{_ )tWUO[`H! *JPaM=!1j^oV*lEVJn!2#˧Gk7b,[uW;ʵΆ͓ɖ$ffa,x+Hr[@d g'F⍡=ȅd!`FD!@   ѭBD"KĘ:qvD,D|{37=~ srIfNZ6T|[P=cX5K {"0;!sp̜ dwP33(ٙ !"JɎi !uve, !P#Z  b-+!1>A[F(.LhA $d$$Zb`S@L D@{Nu@2t `- ,Q0iJ ֪8éwd;3 &!%K̞'$ D$qc<Ġɺ5)%HAČ1B!35R @%V_&Nn51JnH B ˂vB9}f*2sU0ݥ{S}Ѕt'2033dF d- RҐ%k& R)$jfN~uh V;z66/OVz8 Q!h6R*$@ (4kb) iS3`F` Uk+vQkoYK I {F @12 w923HT O h0Pd<'k5Rj#@ =X+$k=Rn;!vcO3V"JIcBalSJ ҖXIB[ADL t2NN\0`Y̜N|T(BLHd2@FRX]DJsYl4291Q1HHi"@`$dH[#1'6&Ym9av|w EY0['r6 ICaY2r 9E0`Xf[)RDIDJF}zuSW=Q"(d#7n})z~Og}{!J q/A$ &&F4 4M=F݉&N@! = f(-y6HZ#-TTo1&zuc#ZzzjLRڴUKV7דf&G!<x[Jr۔$R1 zj5)ƍSS6ׯ[/'N*}wٙY!ub׮sy$+2PHΙfJ w)O{ k̡,#g_r>@\wiK/lL2'ۮASq1cB|-3}.wR}޽Zk`[]ꨧVg>;YꟿիVGZ|8 @ނg}HH?/s>w"UWw3;9TI^su}K U/ח׮֞vi;0G' i @2)R{~1WI>]FC1qDd^_+ݰqäI `˫qܸqJEyB(BݶwՇF_T0TP`dg}| -dW3NhѢ˗Yd )╨eZv^:wtVt_2ޙ)B'; P>)PFˌưزV)"EZv^Z"N12,EXDtK?ӟwun휿??b„ \se}F.s^~O?}q| !"{Ŋ05U4en;idDk¥6.MTPWV%>oFzJ!(/MCDKMΞ3뤓|ᜯ|_|qm?˿ǿ/SԱs'ҪO>yҶ˥~h?wRD$;[n׉DWv;-xO H`4F@ @KL084ԘaW^ 7l%K>W7>{q{~iӦ3tkR800/}SNm?ǯ_^2eW򕞞qD9 nZ|ڵDg9sٳF} x8Z?sZrx twm1ɟRL({K)>$!qLb&C=(b+J,4rJ[%:mMUٮRyZ nSBkҥK'M4o<)宻Eѽ޷>?g>kqNkl61ZknEzT!d.̽j{s<v-;U6^nقE:vX3֋)ꥠb,NAAm$PX6Z38㤓N?nݺ~'tڵko.Z.]tv;~O~zN;$ㅹ1XkWZ588h]z/ǟuY~nO,0yg~rJRi4A4Mݸ⋂3v)_ dMFbݫ,0F“={#6-e&řrs$rt1\tE\p%K&MME{4;39G=Nq1K(aiٜT4fM$G(߉P'/mεַ_Ja!g=WUNt\#:uۿs=?ĉJ}֬YOO4a„3<ӑ'<2P\hu5l?n0k֬ɓ',Qq̼;i*bs+]Hy+:ht=obaiŸН[RjhhhӦM.ZkLAJ+⮻},X1z1cu1l6M)7nܸrJkmE+W?~|___Z}' 5.Wl*?Yf^{e]ƍ~K>˖-ȹǐK)]7d2|o<<ϻ^HF9*kl] B^rhŖ\LTl]zS1}3g.\8qDD3g;Z3gΙ3'A#~vڇ~xժUwG4iҚ5kz+V,ZO}}ta D,x[C 5oT:g7r3"Tl,Er$gw*X$75?9'RE̩^`:-p<2ʕ+o+V<'w_׋}>~O~sέT*SO=SO\{+pK!Jx.`T9$,*TD)V4{]u؆OQ i'sbcyg}vܹCCC/rOOի~+W'N {YbŶn|fҤIFo~'<NT*%6"-^Y+-j!sT>2fx&U=؊ :n^44jz3&Nj )1nnGu.)&.9 x:b( TR,H#3k}w9}^ م]E9K)bC!W"p^d9B#9lNJq)H3kEVƘ-8_B5(11nܐԨDQ^jxA~:t1?rN: 11BjєӁIIE̖@%xH)kA%(CV)ZZ)3)-Y!dEQvJt.SZ4gr.8yR#?BݩE4KҜPjjE1{h4R̠<Q%BDRÒGVKH3,Shu0ZsyrAlJ)" Lf&fWZ묈5<"A*F^浘<g}qd S, )M "tgݣ t;!zUӏȈJBIfa$[$$d`B֗L``J_"3{/L،\ɰ9wT8'%ٰ v$vu>,R$v9%ٺVmFR Mo]T]FQk4FK0@m{u.Ub["d6byF(fȽZi`݅G>BbxJ!#fler40le K`&A%ce?;*"q]yI.y,vWHݩk;C@S7e4Gh֥Z30D(Ox*Ǎk6C)ePmְT|Tab{(C60vy!-OT(iZK$nWEilFLʗQdHWB ZH$oa_;b 22E ZEXnk$(Պ֭BDeHkw[׌4R۞NJ ۩}[zGHufhXmmfXl:2[Z)UFTiיTBc hA#VQEQJ)`6 hN渆9{KK[$n[h1~/DD@m;8yh $7c[!e*6wяN2MogYIe9/TS03-)1V_ROm'#zgJ%X<֯{y Q )Ϙ51'zk+7j=/{ `:Ҁ" n.i&8)N/7%m#@XrѮ%mYoK<6'K !()ß?j~9<79C9kL7(7=/|Da(k nUꕓg >ujYIU(B~ 츍6VSA]_&`Fa: P(ꚿ?piu|_ON:Ukr_8 .#0.m< ߯zbL`lSpZ3&1d'J|M}Nb[)l[Zt~T>VSI85l%Q[ji_3Za2J)ᖝ`>%]ۖfo+H5OFQ[k=OFQJ!0˯:O mՍ>M6Uy f{cW^ꗤ>':K;Sj;J9{9\F ߤkeBʝƍ5x3N3s!m1QQw߽y}Ͽr\6֯;w 'PJ3 h4yz)0aȮZR^:m*b=k-"$<Ǔնns)ZoA3Z05V> qĞ HZd9MҊ$1WnGāfZ&";F$*&16O/#nv/alY0[?ksӮNXE8$grW\Ͼ\>' q晿կvݻˡZ y3:ꨣΝ:,Wg&nk8 խH9ISXa|AMq vm%Yl-mhZSJiD\V{D16uaӦMR^|%o6 g}A rG{׃:8c7i1]7 P,ڞ\2rٙ[h9BȜFV̈́lLu,srM5 Oc^\Ni3weҁ!d!dLpC濖J%nvvgI N)qKH\.9i,wɀ(e$~6$S](3g0;SMRHBr9(Ħ)7 %Qk6H^f ϙ=1cFZ)ک-!mIg;23WHXCp<MZ\ں^,DqsBn1mi8uk=M&?;Rl1ҪAAO!H|;`"^x۳ٷ|!>no3p/ΙuՏ|}5k 'NfӍ O-NZ2O%$ޥEKmH ̙ c6QgR8[6FT[2M)W6Wٶiz2mXd ^oVGqk[W 0}[n-4x?8X!2w%KA0a8%<;<&*0, R2MͩB'h7 )%VtӲa(o `d=_pt{S0<ޔ)km`6 cܰG{\pA߸WZ%b<-[쳟skM;@".^? S6a+Kja#WJ6B#W1"f#gt$ƺeZxϟ|[JzUēg~Z6uS>K.oWvھq29zף°K{TF2 Kg7n•X0Į߄Rd裛7w_wP/ˇ|az)ɧH~CpYxC$9eDR Z3&{QCK/{fd-7veqѢ֭0#|GxW7;3gN &`Fd`B(ML wA!*X"(%͛_Wwq_NG'ŋ+_{կ~mwlm%&o;YRLFDa3}Ϻk4I &+1؊ፈ>I `"_JV06+V,za= Icl ̛foOmYw}_ɓGNߏ'mG7.6,A|c+oM 8lJŕ+m&M ˗_z?}5zHO/Zbvsf Q  `A*1 Cb*CGyvV}(%Ǐ=kϮ每=#Pooիl瞇zp΁EzҤIz; _SL6Q-o` 6xn Y ~nŊ{,GpIկ=u.gɌ3N8 8S{zj{w}k.LAPqJ@D,ZIy-7-_{ooW^9{BЩ`_ZuyO*%ͤIwu6f8Ν;'&txOc?u!Ͽ`(Ï,i瞞?3fL7ou˞] 3g^nٳzɅ;-T:0^}晧 BD:}0h m  ^`QJn;y)S>īyEo<#z=s֬yҧؤ`b:c9s"cZ 5BȰ}_km}'6 b4ѢEy0lNnvX?x^gf3{=cC!%w1=2V H $`A;>{hP7 M^MŦh'D`m" HJr`Jynկ1Z;Cl{ @d-= Ω G% `'Hj$gGCHt-dҹc* rrUCS iN]j̓[}8y7l S3LΪ1=Sgk?PvC6`\"uXE|NZ v*d)qkIね)؉-^w:i\ȊB*Ҧ `v2+Љ.N 8^II`L.nu("+d@@СAi^0- !ܩEo,V>| .)Vվ3' S &S0(mI۠ `QN_]^Aʡ9KJ>s}g4kuGT]w3CNTԆNշטU p'""r7ԵA\g+JUszVLiXBv1Q* '%ӝB3E1Bh 9 e[PU{jQ-煛0t'(&$ƚ/<xyM]LU)^l)Ů a|KH;@WiuRw"7Mx:f+bh"0;\jQXi+C+P& Xӂ@ݧ"A2[b`l n_tL$uA+]ǒQ]_|}˄@Ee`4 Ԛ@EOiJDZ `D"`bm]bv~W^z5{ү^ߜmW}Ј$ H*1NTp;x=H2NgkF "0 m * /@h)Y eJ2q{ 2ɖIe - ~ZSw.O!wHN66IÔ$SEçS I+PDɖ@[zj"I0l"x,0eˡ|dk(0*i@eDvi-QT-r[#٠I:dc  1Xk-"H " x l9dC-:w`UV$ l2"vp^fB½WwgưRBvArϻ{VQ;RVy)#ff)df!j+:R(% +H+աFvցRJ"xF[Xe ck `"22` XJS$Ffw.3[D`dHi <h]m"BDBjjF`CHDRCkY*)mu ^$ % @ҡR̀`-6/4}dmZ[D4&B ~x $6MIZ0lZfolf{>#5#F ւkٶdЍ$ Ln @~{Сؼyw3cmg}#`6 ?,s={l4ƒ9̌lY_?E??8>-[sO?!o?XH Dq]Vll$>~4ܺ,ټysR>w7^ku=׬;vuDy[CO,Y"?GW(WնDRxܨνs]viNBx̶^{{w֬YFJ {PmSG1~8G}Q":CX^ @U3l Eb,bwSDff6n"U1hTz}hb @$2q݆ Z`e@\h\ 6X6 mmz(4̡ĈOR^^dIX#Zg6կ?!}wbЄ_7nFm~7!kK/3@5"F{M*6ٯ$I=0"ڄˍf_<̳9s~#Fկws93T3=/٥˖1{ `}u^x1fƍg}aFtF6ߦ B2(ſсněoo~u˞x+6oO| x≽렃Қ-f?-yb>rÏlܸCA|ƍ|pB03]7ӧzO<V]ov{;GM4ippp'O^poh4w5͹;v3f!:CFzta8_Iėpx^f5^` /<Ohs^{>>ǟxꫯWZ(Ptu"ZYmْ GL/FR2ò-_7 z38cٲeR /</^\T-^kC;cႅW]uwsνJ|i4Ƙ~xΜ9}}}B;}Ri==ZWs+|ۓO>duV3fJ)}wׯwBJ)!رc7nXKn\y^0 ]z .ZhD,JJr /I}V\ FR R:N?p;[h(< 3 4[:Ea:s[ЖNe;P3"{o!Nn/r#96{e]{|_\|3?곟W^yG_o~/˽[hPd%Fw~{^WZiSOk!G; 4a%a$ポtdu1Bh6mrM3cuN:o~_|կR솀RMvf9$(ڦ%Ọ;- R.geGSO,YÏE?fB3OvOR!""r}^ !!^;fOOR*- ȍyҥ_sraJ)c=vjRD=uRd'vLKsEa`49CaZyTtL!fs] Y̔M3ܢ6M0yo\.Ϝ9SN>Os1s " x￿֚\:uĉ|}Z׬nZ:ќiT JS-QlJ3+N/"]܉NV1!*.=Td;A1FJ̣G^n]٬T*f3w޹T*M4i̘1,4iҚ5kyTueɠʷ%¬'-:1f)nݺŋk׿\0aŽ;x뭷Zk7l&!Nw]wƍB3Ey!@g*]-!'_84  jZVN=}"8cn z{ pˎ7+˳f6l8ꡇ:wܳ:kڴi{iG+8s&L0zjFx'N<3O:Yfqw{zzNiV\l6}OΏ<ȋ/㏟0aB =2".T[&2aIk1ӻI[h|))̜'/OvNE  0*]HdŎHaxW}ʶXE>bOW~ /|s}Æ {qjժ/|͚5fsgzzz$jVCġs9gƌ Z2n2W3)@Oj s%%w2B>i ԒS(BWH9Vke e˖=sr?O6Ow;iҤ 6z;3sxM6xgo}sz: iMd~&w$sS4ŖZ̉˛M3dZd4 [&dF$Bi܅IPBB13)a-UJ iHD;YT 0PJ1IS"Xf"$%$_*EXA`3WzYB0a$D$ɧ;Zl[)j-$R(Z}@BJbٖ@@DdBF#Xt|lIO c Pk  Xmү0-0Bf KղFExmBK0"0d j  D&$`k RH":H  . ,;5K^u.hIhn}OtBSf >p#DG? zR10 Y!H2t&; HqdKKNG%AOA @JNx5m\D@ -0 JeF!Dd]K:@pWQp2XD! h#$1Fྡྷ)NκjTjx֤EFXކI 0x§HAzr (rь("@aL5kmJ+Uz7o,R0 {!""hMD40-8ٖ]:T)KNW*jCiv}8]㉜|au3)][GYk#jZRJh4RJwѠz\.7qp9SZIc2+,E@r3es,25v9L]gYhGE2^ӥwEwض[w9^ d̈T71J)ctfV+F eLB0 \ p WYcTEsN-ea]є#  MP))a7 ԥa)ֺ'L|)C:'7;R}٨7Q)I̶[@Hq;Pptlof)̏>)o3f,Zt=ƘJ$%5ajSem,+Zk ;N;S &[n,65ﱩ6&r9By$ǎl3+ '&6rGG[ZEI$fP̥R)BzeBRJP\(V.y6Ƃ{A rI F3$! "7'4k$t8RMS!Ex"HDx ItsfȜ|tZ14ˌ1SY%\ (ia 2 @^qG'e`]T IA^IY7J>H!rlj !ȅޞjVZCFa\D(qԲq&q_38s;|ʊsV˗}]ք} `x~8800+6m>qfB ^z%'|SL-(3x{-5$xMW'JQV8ʻYYc6奌 jtrQFb1\{eH=s.$6̹V RdD#5i[DIH_x x1u@BsK EVn ;l.\x-4jWa}O>3w/T{oӢN$L'(=d"HiT 0 +u{pisMws"pBE ayA!6KQ _[wdlpT$s}L3U*Pp"6DDpSY ,sf\.e]oɳO2eRVYp;Bm1 H-SI9tm ԁIHܼ֒A@QhtRL-ȍ]a+C۪KF:K.O}F=BWlZ O )Г =EB)zJcY)BdSH \vܹ6o\k ._[^{N}wyg4}O쉒$AHD'{ZȓyZJK.:wSB0񍾈]NJ `{{RZy !) i-꿃26P<m-m0aqSѺp"(*5F!.;)FgK3 $Q&ظ!v*PjsQ9U=gVubqK X0f`OĻ&evw?uGN==~=ϫV=׿wv)?2Ǎ'x%_1cO>#ivLD7ĒI$+1%l*Alfbݜb5+m*¬ cSuxLƜ0{sh.AY5s6SIsDش٤d92q8 $#9ckz9+W~o>?ryÆM6?sM9~k׮Z?l?kjn cI}7Ii;#-cH{E33J$ I(k~IWՋ31:gѧĴ ]F,s]eίsBGT?sݧrjŋo3kwyG?}=zg|bW\?Sri&Mϯm6׬Y|t'/^b .'!J4#߷[w穀uϏ~+Vqw?٥4{S<%o3^o<䉾QOa| l>O뮈W\}ܱ3֯}=[ )B$+ډm"̲e~ӟ l>eGgo{Z?c*u!JlF1t_R!ĘwJjSc?鴷NY8B%$S[7Qeƚ~[Gc$VJ[ܑY{ ;/(5ٍzia0'b[4]!i2oTo__ڻwyԔ)S֮]OqG R|;9']ZbQ$07H Jԑ&| OLM9ԛXM)sW5\38X{g.zgn~On?T*k1fE?aq>3IO=duw>xϯX?>?Oq᧝:{Ӧr3g ǿ[a<#׬#.|Æu~3Bʬx` _ϯZ^9}g~c+x~BdZ5c.A<$ŭ61Dh4Ԍ{E"m'"(Jwd$E1~&؁ rKgߐMGq[bkW*r*H$骝ڍT*=S>gW~ի7 \yŕ]E׬Yҥ7m]__??`03Qz`Hm?G!/kEzi}ciaNRVf͠X;b*֔m0)Ș8\ء0o-ȹ?2p# s6(rdfxرzj1cYJQ*y&LXr5O bˈoQeY`쏅SD0ҡH9qXH e6Ht $rMJ1z] VPneloaf{GJw?a8s~Ry=s<)^otϤo1c .JcO,W۳vͺ; >p?]zcA_Ɯ9tGjFmħ2I#ٜ)C ed%s.ƙAyBvhi<_ DRP@9?3pUc9 F.?~|g>kpp8^k#K> HaRF])ʆ!"0ل4y]s!fjiTeIltnDS f*JmB1=JmR 0[h 3?J^oJy+V'.RYC;/UJ(%fCI!A [5s̟]uuk|>O]+Boo??2kP{Rl6˥bM8r-Y~ l-]Qv }}@<ֲ_w}Ϝyu;/^)Svyڦ!Ձ:oUN82zaӥp("^B-REOϛ;sܘcfoOѳ?O^o{SO}ˎm4x7G %;{_E91OVaΗNme,e8|w.N:D _8.guUW]40aoO! )[KVVqBbprDF[,GWn9j%Z@ `,[;mwAh}PQfYd A [uSR&,Ąqcvu/}JP0٨X$!Bc<%քl[o+9nÇZIY7z{2u;_DtJX^\ )h=O!XOR~i`FmPՒZ[-岿njشaqrk{.\r8 )DP/,w[Aۧ|Y0wB%[w'L Z`έN8Ѩ/[t W_0Vfzm{p;v3Yf͝wΫ/{qMJ%栉P)Y  @! `˥ޞ_|ﾫ_|{/ZuR& $"̜93 '~/ ׯ_{{mVqN2ww9oJZn̡o708=o\A[޲~9sNnjZ);5WK)y'|R w>@ڍS?_ȕ锧s'T]uǓg_juu'>/-k:U7| B^[NRJ*;ur}E<|c>Z֭s;Xֺs#B^^%t4˝mUSB)v Nn1[w3γ]x5\*Əfꁁ͕Jiҥ4ex/Zk;f\))*yZքa`VXY*Rt;4Tc8^wݜn>}g98qP??@<?]v-޺T=O?̘1w}w@,<∫{G/8m!-Xp=agLtӍƍ{qAwXAh/wԆj_4qw?G9w'z-_:+Uh}ެ.\+tZ&/<|5̛wiػzGE]Ͽ>}T (  7o>C_xᅫ;3g?;e);Ӟ{MKoZvyU/]z%]~ {ɓn;!DR=0`R ew]zfՄ>޹p{!Ma0(phhaPoHg#%#54|/.)}9Xp U3HfƂer\1)Vyf3JfˀZT1`dTl A$-/O;Aa|{i_8(} d&dfmlf- HHE4"P[@ LTk(F[Dq@F1dÏ`!a/Z 6 $84IX :CH,҆IH$CԆ28l1uB0 1 dH,xs?$c4b˴_؉wF[$ Flil4y0 .0P1 PMP `cS=o``Gg`f.0HB El@t=0FgB(Ԁ>-Faţc7`9.]55:n'9ቓyV8"RlOOexG3"h=oF4בK5ʀ#uRz^%?k `^}B&K@,Bʋ2$eG^ 5qܩ-:cjZ3$#3mގ'lD+8FJX8 G dmu6?hL;i!#2R )-Ӻkݍ6;beYVD۸ #j%uR[DobESYW)?آPdL46koY1iƳ+oy}&lgZ9}kɒjl94kZ-bs!%6„\D-Cw&K2Ԛ B;Кpm`в|~!T(3 cIR.Z ef:5Pʗp𡙍b_0N~_$ r19@@ʀeg}6zDFH2{b#"f-y@j=7͊ll_k1Hdk@k!C7HptmHDS 2ۡD&$B"%!AtsUQ:(OqR*!TA ABm[fȸIizM@j w+d7,a2|hS˟#| -!\YNzW֖ſZLlU;MphmBM }͹M@Q!AqAj"T P  H@v&ၢZ5kQ%.g!(;\!(d. |-Ѵ}{~ 8[ `R+:+"Q^S- a4Jm ٹ?pAcGm =oOwq_-j#áj(Yl%zݩ2__7K480R`a5D~AQZu)K[_ju<4ӏ aHH 6A(A D !(Ҟ5_m˫ɀ=TI;-]o}_U>.EJϿ7".x2$B%Bp h4 Q@$8\J0E `R`aGČZ\kʿ\aANv'z7[ʰЂ;x "BPDw2\9431d )%Ȅ/8c6CFJywmȘ}R2,bC!yB!'Lm1)Q|Fpf @k#wH/Q !P0. ~ 8q[F7 hP H"B_T P! @@AHƐ@"@cDeIF9M ^L!J2C|-Q 2mq)}&F[JMJIl!@0$ HzFJ#gy<BDR 6~5CdB6Bc/$2@lx!4hR*Uy{u &x 0@:e[@DBCZxRvj7B 0Ezo{?b   <R}m I%9 t=OY2 $!;O]ϕRѴ7 Y"2h @c8O-g)Kk-t;}ۀbH ! B P Bk{Jy iߐ'QJ)o<ҵ"ȐB5 4,N7`s BPKm%iMZ((1v[* p\U!k)i,eH i\ӞA+{n@B= ) TJ% Dm|)#P5CG4yQ)ik"pC`osQK26lABI@:N@@ |4n?aP=hRiߑJ&`!OF`Y)YBNw({X4K:N4QYJWk΅8!n$ZkiǃRRCC6E_@DP@׀!0 @ZK! o1.RڑBr }^(ҳk_DT}_A>'@DZ{B DCFoܴOޱ_Bo!}O-!0DDv-"Z27js؁eu@B zGH)ɤTR)g1ZTRH6 `3 @;"D"}CAHc eY|O Ttl$ '/D C4I˲cxA( H 6|߲ls@8tIJ@@2>S \`OT,A}*HDl+t!uMT@HrQi@ƸTNNL +dԒF,'&15t4Z[Vu9h2?F55%^NNT)e*q@djgDa٤N~B|n $s=@:>J!:t(0|c8ek)d"yI۶hJ#}낯XU;ǰu`xI"$H{Na]9OjB߾Ak- )6ZКwb $BhcH ҞvG~wչ2*Fc _KwF %$ TP8a,gݻ$!0L$PfȤv,xZk%1J!Y1 T8BrJ)m4׹i$@@[ ܳ y{Uک&@I}F/P)͜_V9fE$o ;8@@"5*iϟ?G ?{ϥ&u|b[vlcoݲ%8?򪫯Z}۶(|M(7WZkN|DRh,Se՝FIY_omԩ_ݩS'c`Ӧ>hco`I-TVi$D29nO?|2 Q  о!08W=$#@;GAvJ; o9穧|)^D嗷rK4B)Os&'zR>[쌙M&!O>$2B) -(9c)oRRH"V"DFdIvOd?;WA~x']ϫ7c/k>G=}|5^3q7'7F|lRJ JJ|51F.VQ u@@ ER"ej@ -}z|r d=.??RjϞ=%%RVQRRՎL&mnjjJ:zۺuK֊;4D.ƶVnYlI'IJ>LܹS!,вx566ڶ8N}}}aAaaB@+X'}ѐNj~hó ܆|7?7빿d6T<4?{c (j"C=>޽{oXN쪫}u{%"u}oll,**x<^[[+,--ecu]fX,&oɩS#P'≽u{srr:w $7tݻnjȠ@"?{w^3p .`]&OQ6lpgN!N;։D:Obђ6A*٩S')vƜܜU;yٳ'H^ )dwxw}׺u6mh@sVƆ=53K,} /0a¦M&O,;9Pkjj8ƍﾳ>>o[YYoѽ{GK/͙3 r5ضG555ڵ_~;nʕL8qС!C$4Yf[__nݺ}{guٳn:z+B)uɓ'8q '/[oաC>}(% 'Mtw.X୷jjj*,,[KKK_z5ktqݺuhb>x/>6Ȅf#f \ &YFR%[_O(4ڶ 2D"u˖{??@c4='7.""˗?X3?_2444}Æ ?~RjΜ9sνğʦcǎݵk… z-u|uc}h4u^z]|O>d]]]Ν#8S ~e=0`Z]WTTDSOevp~E"7N8G-++,_tc=&Bw޽{EEo_\vew^SS7|Ǿ?O k?sss%7-O"K l7Z7QIŬȥA믿+y$d,+//fs_k]^^yމ'7bĈUVu֝n+bȑO2es I'7 [Ӌ/0ac=gϞ=`oW^h4ʴa)P]]]^^~ '| ,hhhRΞ={ʕӦM,?~޽{.l̙]w]wݵsNqxm6uKKK#8V"~3ϼaÆ=-Zh޼y=،36m׿niӦusNNXbȑSN=zd2>!,˪7o̙3'Noի|3}={|MT]]ݧ~zL:sSN۶zju)-s1pd<6_l׹* 8<*\[x<0ƔѣRJkD|ߏdbƌzC={n&"CUUU"BXUTTTSSy^<=fϞ8N";wm~t3s=ӦM+//ݻ̙3|ٲeڵ~wϙ3bڴi^{mHF뺎㸮۷o;l!y`ٺuk^^"HΝ]sdzٲe |f:s.dڴiwy?{UVm޼y̙guɓGsϝ}َXEDs7J'=43oҾ(өb#2'KF=\-ki,**z:ucg\׽'Ns%I9!D\mjj,+tҥR*D:vد_^zd2[o}uuuwu9Ϗ7[nB !gوb1 R)ǾMFM<Quᢋ. Rq=z}ر`Z#<*L&?;f̘h4;vXhQeeٳ? 6رcʕ'tRqqq^^ }v5Jn׮]eYݻwӧc]~}CCw^cLWv > -!B^yFQ9  mZ?SNOֺpwyUW]o~zc8D,SJL9rduu_~YSSS^^~g{dɒƗ^z?nhhظqcݏ9D"***ھ}{$1Ɯ;wfgBDzJǀeYRJ6ԸQ, y7|sȑH$|?H$d!D4=>{.Y۸qcMMƍ_xm۶^Zk=bĈ.]xWRR8NuuuNNNǎ/BÐ!C^s疖rd:y80L:KS3Zri e5u+l]1cxׯ_g}vĉǏ_dɽޫ4hРAyW^yW^Y~m,RcƌYrݻW\m6o޼cǎ^xaƍÇݻy]vBd,/&"uhѢs疕u%|-7O>}> 1x]kD"๹rL&.\8p#8O?mll\pK/{O>1czשSZwᬳbׯo4(??5tm}i0a68@e&-SqYW,fb6sѨmۈf뺈XWWt#Gy[z999z[ ,̙ӥK־EEEoȑ# 2k֬۷/[LJ٫We˖SPP0iҤ;RjXp+"J))%"c#я~Էo_"*//'6oܳgO[" LUC< #H)xo@N4#عsg(,,%t]=0-zĊ+?tek6+"z(䒬lI+]TA*dFDOBm]yVt,G<~v%lٲ裏frض]WW!^z>|xiiinjkky:dk*x7^u-[vJ4SN{ov;NZW)y̙;OǏz'x{aÔܕf}ȑUUU+VXtiֱcd2ɶII]wy֬YL&Y9K/%nSO;XAf%RjM itOo++C3L:fpWF ,qlm0޺uym&Loz˶?|ACCCAAA.]rssY!CYt͛G٥KUVyhll|?Cq|ߏbd2я~${ r}`bU8!DAA-Ž/zĉ„O{`9⎥͘1cn 6,Y?eYMMMq?x6vcرe9Ò;|ꩧkvܸqNܒa 3^k&Z(B$!G`{5{J:tD@Vu%%%7ndn(Y(Gyyy~XsLjN+PS|ݺueqRʂ{oƍK,͝4iRNOW\\s)qFdcܹ3v֍}^Z_{_|qw5nܸ~㏟>}rDdI&|UQ(A~$1OڗL&Y3C!Njv[}sFl 88k3.ғ)F ӗy"GĜ;w  .I&-[N%a<1cƫꫯ &ۋZhڶ}駟uY_o1l0OymLhrI& />eʔX, 0{CCCΝǎgq/\^^OcufY֩ڧO7pC=LR[[Rf\Ƚ%%%'N7n܏׏1{Ȉͪxjm?e|oVچkX[hmQQK*^ȕ }`F1mB0c}Ƙ?shsy+++ncѣ ,˺|ߟ:u={.fiqY]]zs_dɒs=BGDqh43TVV.Z護bS?@tЁ>㪪*f2?O><"n޼9??˖-m۶ɓ'رwާr#?uGO>r3gZ޽_g ?]<uڕ P-YmȦ2>[_L_ƵfUw_vرk.Qu/^K/-**ڼyW\kʊ5k38q9s\}{9/|ꩧFշo_U)eNNΨQfϞ=bĈ2D=zt~~>yo뺹MMMׯ?뺮ijfΆxO>ݻ7;QөAvt ɗv3yٕݽ7y6B*NUu(./FC;~.]uQHĶc9߻w^z.駟^^^xb8㌼}>cwo޼'?I>};wbqQQѨQ|իW/gWJ5o޼+wZ3K xÜ y5;y|P0# (eY̋n p~]?? z Q/ͯC YHLy1>s $VcǎK.2&PeB4P+WH֛ok<o[Gjk ȶrra2v(µkW8l0fof?VO)()|b3*Kv}D;xuWwobvF +%ֺ+~7j(żĮEc`s6 d2OTUUs=mK!ѤR\!R/H p)cW* 1<#z޼y=k/<|GJ&{ܟ shP*neWB@ 8,Pض+cZ=!l5DE@"",e`9L'`@m4+imm[ƇTJQ#͒]IIR!DWWSN]D<W]uuCF%&4DhD'p³=e˖#8yBH>maӾF Jm*݅|Z7:e[٬N%5d,"CyZ),KARIq!c JJO,^4`#Vj~$ueiߑnz7|lԭ :uF1,kիԡ1yDWN: ⭬Z9n=?ҐyY H-,ҶɃ+hL/K=aaX^,D,F&b4e$1:Y޴ Hjb$EE%@DzױB4ci)"#BDlFr&ui_ÔoСJ u^ tW'"<^UT7Yc g~IwnE5ةcg!hf F[R} !n-N!(%0DD( nD(h}-mJꛁAo8 468`Lf6`&ľη7l{(/]@(B$Tl0*&L@J9L@a4} 0Q SdxS %`! D@Eh9OjM4 SOipa8 aƄ_Xٔ4&Elm}sLF" !H`@<a8 0H #$ _#Zk{ Q>{_84 AA۱Ara8 0q."AB)%۹1,H7%mv(IA:a8 0qgRD_I` JVH)0dQF+L 7_D; '[vc_@a< BiOQLt 1@>9ĮeiCDL )wvl}h֚UpB)8[h @2T%P9"ڷ,k?1H!F@(јvcP>Qfb.q!a˱I)cY֚#a@ăj=sQu7B(tJ)`@{>(IG´2ҡ}I$i㠶H?mIk[rO[s@@@hAWGSi|HXg;̸_a -YȠ& ۖ]_؎(Kq3q/$a4Rȴz)TMP/ɳ?m@AFsx+"Qj)Њ8D8ݷٲ>.jYi9iF kF *H; @RʈT@|_=#"}cY0;Ggollm%r]Ok 01 ,3%BpRy~?־eI]C>6[55ŕR`#Dz(zY15,ZP$I$5J?5W9/SF@ :."Ǜ(j}HܤiY"~o2Kr^jfv`Lm|o2QU|G!r]7L@9KIɶD"%];)B%ֆZSD"V" \z]fV_Ҩp0U e11Hy:*HOT"nBj"f* 8h4J#|LL~<+,̳,/\ņZD"RMP)CV7oͱ)Hr8ebFqy"L5Eh-/࣐u3,VHԂ!A3rni(3!3Y¬ bឥVךg"66oKҞ=JΈIb۶?_nx!b ql;HE )7%Gd!=֩RMMMumd2# udxƘMMI\s*XkNE1] ;D\aPk_HᙆRN "iW Nd4!'ERh׮u\WYV߾}rrr R_yسg>}z54Y;Z0dh1${KHDY$^-7D o`s/xRI𪪬N%=HeTDT蠨(k/36TF4B $$sv~{Pyos<7^묽ګ|ŤI>hocAsŊ}_sϽK`zQHC 1F@PSgk dv)m1R!mdg9ک%mv<2gδۧ74"{6IRڊS˴:o%mu V'T6[)E4K%p3!紘O]}Yl):=k y#I[(e<=ʔڼUJvO>9|Ï~fUUKBd!,$d>;B-rƤc2sƀB .8ctv-fgPVhPb8)9g6mR%3 ̶@PjFBpMɌQE#Og>A9T#\Bpߏyޖ[:ۣbbmIXcQ(^)QQn+j=>?5wVV.K";vC ;:xy>}R Bd2>}ZK|{~qs8TU%B͍ǎbi5 !eYE%>oGO65OLJ1MCU TU,\{`sܤܜ.$9)#vrΊ1MS[lSU]Jr<&6`>)Aaqi#GjJ#PS]PRZjxcMv'7'*,,R4]Sy)ssj9`̲ WYYr: J%B~OA bڎ6+YY donKuRB΅:tUI$HMv*|CHv1%ItiCB FL".xΨ0sd -=pj7s 0V6ޯ OL[QyvΠA,:;*BEUQ,=X]C u4UaNK@AB4v8\EN5W_CU4g0֋JySQ+*..!v%)%MJkk뱣uB~5MWb .@FFFl\#ǚNgC!M [ZZj^@C$.쵖 H ҈afN Mva T "SOݮ"tƧ}t=c$o޴y_,h8?oqr[ϧLIQ`hm9p8U0f-,p◔a9ojlt:MMG0k:P!i,! >8w)huuiHCmn>z31Mǎ=tGANy_>ˑ[NpG<xhCC]fffVV"(^0%NCig= kaee!"!đ'Ӟ;oXɥA֮]_.=^|@UVfFEﺻY@JZfuyy`*wT̂^[voٲ9>!1* 1ABaq)uݺ^}SO4h 7LZjM=?mvΚuoSS+/b~Uӗ/k}7oߜ˘kyܜõ .t:]ݶ}=ΰa7{ l^~5 s{j~عsF6ry#F@W{Q.W[{ۃ>;=r>D~KJJfqgn޴oU7xߜ?;w9曧1cZY٠بõ Iz! B.`ê?xW6߶}W^Pv6i.,*_Ud qD;_[T\'AO>}Ec'N?TS8߸qÍ72,\$r. ;n4,Rc;457K~ڲ`S-\B~r㱱Bʿ7\ݳsg{!%%O?vׅE%Q>B^TU1reLMDu7Nr3 t j9?eڱ/BzZǰiӦ/ =^;^yma|\;]Q7';Db+)*`λ9;bMOz\0XNْ]#v `$!4N:-]=@hSQH5c 1BJӦM9c:eB|ۮꊆc/33CU}p}>l۶nY3TtinnvuuMi3f8p`?|p/vS y/xfȠL+<++Gu[~%r;Wmeuu8W^` |>߼'{뮽" /{= [nٲK VT8pi;wشis﩮9ȹSn3fѣG__fqaQ\qŕyy. 橨|"ǾOٍYmLQa-H{! 4\) ![9dП6tqR?˨QnuG}_ qv=3IIɋ/()-;Q3I|Bºfֶ oykBb TUryDwo !jn~֭[*]>} UUofSSˁ*+_yeXmmݰq:!9I)ɽf~hsχ.3OΓRXW_y_EqQу:\[4EVU=<1 O)kljJNI,(3L+>!awU쭸[G_x\p}.RfuΜ9y_|G/uΧz򪫮AQ& T=65H,UƈEy睗csvsONN֝wݻJJK>}9szKkfl.|W|;n4a ă t8HVv˸9jԅo,]_0TU XgߝN/;]s$3ϰ$b{0H;I]֭[{ bh8p NMM%AE!_qCpMܜ- <4)׋/Tگ,Ӛy]ׯ7qƦ??Θ19sFZjk=rgHz"ᶖ|w \TX`ε@i^4v1(c͏kGE[ <)x(J0h0ƶp;[ze/xJtM[|'_~2 !=~[qe #X^^&C ɓw۷=#/,;;355Wb±Ʀ[Z__WZڏ2r裪'zNnp PUMB auuG\Ce"DH.rNOD` }|Jkر7>;;; Wh Xuj}O>@Ӵʊ EӤI LLIMz=M-kԔdct\0 꺮* hY-fgg|phy}AC-SJi{g457 80~xUU ++;̳-y[t:cΌ~衇.#GPo&!v! &)++s^_մ`0X]]k玗_yp?~ !+)2TmmQn A^^> )),7MqZߖeegee3F8).iyӦF˴NojjjJH߿Ԥq{CYl\Rt)eZz<9v9\޽3ŔqJܲ,ι\ g9˝-%%t:A#O6E߰G,k玭(uu =w8(*:az C>qž)ׯW!Q߾6mڌrs"/!!=uuuw1B*cLT0eeeI6nҪn5LcTp8]x}> h>~Hj`08jԨ8JYii <9 EEE!ECX{5.H܃sBȡCV^}}*D2TMwtxUؘgOy}]mc㱤$]w@HK5W%$N0ĉm۶ڰx{G{aQ9"|>8 N?^w8Ak!|c>rUPP@-fӱUI^G_S] $D Dh9.Yზe1zu {w#+J׹GI\p9Ec.zdC=6kʌ `pVgf5 ?aVlea)+*:kkmiQ!4 B0cT!*J RbY{ABHLQЦM?xQKI#猦$<*2dDRs*>  CP .ǍdɒoOFEE`aQgYׯBC])S]S )ea@H[.`GGE1[9). Hi;K1F0,Cp @gee2.0E1Bp!8L8!Q6Btx: QλB;fNKܰaz.!DԢsjʕ?X  B0Cz %#*JRoRBoRS0uMqC5Um.PbbO?m]Q!5>xvZ[vlrꙙYNSJv;Ͽ+WXf 9))99U K "%-EQ0` B1 H@0KzGy뮟4iղK?}+ BHJ_l=\]Ur|ܜl!̛fLxǟxbޫ'@^E?}~~b˥j?$@o5>ױcG}ݦ&a\SJ-&h?x7x F9 >۷[zecƌJ zN^;5M+sssWBbr}}oh7m0 `A$Bմ/Z%K[Z_4)yysH [m$ N !@ kV؋ƬZ²=KJZ8qO{{ZZzRYQh`P#7&-\;HNN9595`Me)  85j߾K&SP N-ycnj~g.F(sKI%%*Pp$<#=b.HCCRBBb|,AW_SPW!U*X2pLdסU)'1@ cR誂 qٙiŦ$'eDEE3j<3cǎYO HA`(㖡34>! `$8U` A@*I]H <999 In3)!2 #PWzA `,8kin\ɓ&=ܳ: IN RA FJvJΠE (3XzzԩNpF`3KUiP<|Nv (&S H~}AJF>w4ܾu-?{@J(CW%g{s vlGP0% W^>qرm-'[7; $g!T/}Auu{3tXSOL?r"7;;%9%595ZjM_xٹ=:p`rg@ fZi))yxQ۷ GR"(HJ}%9- F4>Oˉf#yڌQ2Mog459yǛ-pf!(/x͛?T5-==33#3&:.&W_VUVdcӯ_iS5A`ZI~eR1RFA@P.nzsA߼Ǜ[N6;B0N ^tц U v98)dZzFRRrtt O>y=K,~r޼ ۮԡi@(,';'̬ܷ~g!% " PОL@"Hpdk'LRRSWIFf?\woBBի23)coOḫ]g9rTKKKZZUW]EQ JJJV\Gv*}ѣ-Z{Qv;ow8qbǎmsMHEA>|ʕAصkE)B(*}׬tok'L`KRB*lf̅fͺ+u]ꪫ _x555eB1Z}!*FRk>(0 i>Fb>"^>xb^nN֑]

YU>zqׁ^O?+srrlb4t]ڱc_n~`0Fu34ƍ7x>޶(=\\\,$0MS5[bŊmڴi# bp(eee~: )Pɍ7p_ve/ ֬;T"P1:t`U!#F`LDGGϙ3g…G`}IIW_}>|A]9sߧ:w=vH||bC]w]kk}WZR2A0qD;jDn{HRs6zoeG8WQHJjԩS,Y`pM<_~֯wkk>9(y@b=( bWSC(p?W5]yH7dgn+?.6 F 0,k ْE<3~+¢t֟Ŝ.NR6?oCyyNqƍ.rƶonD4 SkkNgFfoOgrWзd.6-zw3֭]dEAjZzqQi'NطRJYXX1ڴiСÂ@Ձ>/:&_~M(,>[pk22zƙgϞM({-(ymnQ2x eƆ 념}i9RPPꞽ}cc عsgaN>mɗL"uZ]zƬ\)Eõ))%RJc׮R~MI Uǧhi$mim#PViaU0 A/zٳgcGrN&#v=SSs"~]cι 篺p$$$8{rrhi9Q.Xvvvvv.@Q!E0|wWâŋ].'BXӴC>|2=iEfgg?~<4 B~@'RSS8s̼喛1! QL"SJ!R]JJJ]N! `QJ_~pH)u۷c|˴*;|\Qդd]22kTgeF۶mPJJ.,,M:͑$vG\(>-^:g,NTH.Bp(AJteezzz\l֞=SRӲ}>-Ғ,Bw8ܶK0BVVko;;#3Qb_wG$)ۻwa23O̘9cc.r.)I|U5!B0]w`3eAw755ڿBB/ -[(eGG$$$TT+)3?zy _~ɓ)e;Z.c! `L p:tBȆPUi1 v!_Q!?Pp%@Q((iѤ^qoV[z#Ba q!9 ĸE(Ä@ "a$BA1QrUUBiʹ1&iaEB/KМG"BJX!I.30 ~B:QU!PB(""dB@cb= *..b)c9HBeQE( !L9WT ɘ@Qa9DB8P!B'wBƘ;XQq퐾@(Ę@$".%& ɹPTq.I!œ VT.8&$4!\HĴqI-UYU]]soB$ iGRB;DR E 2-*e\QI"DB. Q]jɓ!q .aWJTM ::K.镔BX1kZ4]B,TMB5q5)>!&- !aLAE!<"%\@dQaӲB /G߿GB B"DE1- N)#ƆiUU%P.㝻T!НiQLR!!P4ʄiZ(AÀA0fffx<" @D5"$1B )L!L)Gl޼ĉws! Q6 DE +4mt !#D BA$abB2 SQ*N.@յɱ:\WM @ ;C H! %fk# zj sǠ j3G8`DG$0(CQu>4uS{ㅣvG%@-H l3:t(ŭrq;HQ B0IE+C{pX2&sE)ud~ņEBvV茬z6]ιEkWn C6 F`2]f8q^"zABrfEg%_؃~"VnBtt.)i)/A)!z]$g$3AH A]!z=aPv45LTRN>#|MlNd.6l0/p !8(oWo+ˍ%B !gH  rm.ϥuHuaiaHF^pNmv[Caw))DݾOrg0<ݶ;> endobj 95 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig2.jpg) >> endobj 96 0 obj << /Type /Annot /Subtype /Link /A 97 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 333.5715 260.2500 492.5715 ] >> endobj 97 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig3.jpg) >> endobj 98 0 obj << /Type /XObject /Subtype /Image /Width 600 /Height 205 /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 1 /Columns 600 /BitsPerComponent 8>> /ColorSpace /DeviceGray /BitsPerComponent 8 /Length 541>> stream xA 0 =" ʝ<2;EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$EX$Eb(O endstream endobj 99 0 obj << /Type /XObject /Subtype /Image /Width 600 /Height 205 /SMask 98 0 R /Filter /FlateDecode /DecodeParms << /Predictor 15 /Colors 3 /Columns 600 /BitsPerComponent 8>> /ColorSpace /DeviceRGB /BitsPerComponent 8 /Length 85894>> stream xy&Eu7|NUu;wUE(IFq(F$L5&AQ# "0603w<]UꜪ~$~qZJ B"T ΀03t'L~1:bXFulD5׳DVT("LjP]utW)L&[ @)Du]/ƌm"d0\aԅPL'I$!xVΉ"$:109$B1%8Xc az3!3gn\ug 3.;BTd `Q@2Rg4%sr|rA+ Hq % ADqdq;1%F3̋R6q$5(OVSD _nJZeY͜KN`b$ 'uʷDq$y1q4+M],b%HB)} qf)j12{U t7Ȇϼ.q|ģ!&R#8U]9BWt uiͧ!e ]!r`+͞W/ ]#c6|؝"cn9jR"O(,bD@{7⼼e樚1 A\Q8p&Gc8ϵ$a40G#(J@"$ct='tk@&\ Ζ|q:_KvEPJV D#;1Q`lFee D!5&v!-*#:gN @E_95ӓDJWɺh1)#2f #7t,KXG +D^l(ba$K$jNjI.:!kIA):` ,x!̒tl?@R! YJY8A#W4[ Bl]FXIyb),}P@W1Bp<$@O"*Qր9hy@7,I8a.k#cS&hf+' . $3Œdw0tHACÔiq~ø8p6_@Xx V>qύBAC7"1"eO#KlȮB2hJdԙ%R:Ht" Bv񎐐 U|X4 d#1W>*˜څ xI1 M#aH#)Np _(xq'扰3ىq*y1pbL|l!Kb.D8J? 6,( l=SFq|qP#`U"d9K)ӌP5k0 ?ȋIiF$U^'/J !IBbIHn!W.3U#(8فt+I 40܅`2 @?nydIQB{bK2*-X~ ;Er 7rG&`OvSt1׳55(T["!g3.1"%QƤ,>LEDW92xL]#%{QYKd(p5-%$iȤh=Xq)҉LncBO6bc渆g+O?)Q!eKPFZ ,! 3Фlb)l޸e0$ٙaE$Ob}3`V̱L*e !s|J=?f=6qPDy.im{ߎ} ,BgR?Ƹ^ ^OkvW^ĸX?_3)=QX'uIj;]/%yj'qq3ƒ}O %QNAcdȄRW&d͢ KzJro# \\{!e|e7G1d--3FXwŔ_Rk9l"1Jvx(u8V/7\eT3k`7L,qxIiOh1y^ESW%.@>y RtPQ0jnzFi>@ii:0JJR:VLXA#9s4X|{ǓS,LCS׀.VAn\ِ`Җʴx%VKtγY{Q-1a LQV)2u1:I*r#q3/bEyf  A[=3}ȁ{'m bP72PmL }]r5ZQyDRM+BvCp%`VP':Ulȋ[2DW rDV*MmItߓ Pb$ln|FZKr$(x@,l;Z158ݕoްmyuo̧ O=\_1ന"DeRF`Ag^ ?2_^t7hf\NwGb4@ Lr+#<A6Hp$Od"xm\JMbvPE%/W)ːHrW̿rϣqOܥ#egOS䔀{< HE;sR슇?C-|!݈줹l͎PKz*W&tԤ?b-Ló\f]r#3&$+JUQPZFˁECc/05<_=O^ӌ\S}oHkMMVgp=6_&^'rofN~.a, 8dec?:&D."ؒwKxMc{% @ TTTIoq -*WzŐHVEŲѱKB@6̑-9(q_m kd>#O:3K 1;NAdθOBrhlxoQa(Z9q,IβN $]D㌉<8d%8d:Kܔno&ҌT)$;3D&j&m J1N0[PUsF?)oag DYp( I3 N#]y͛mͳ8gw͍{ܞM[xU?-nҎ7Av[gͣ5?keg{~kV\\Xw=[@OYC"'`NpYdI{uxK!E,'jQ1k>r_> ¼+\E;Y`*~sE$x=HƞEx*9^JqJQ'7I?A =Arp?ʕ_s&ڕ7<}.vYg[~pkw]q􁧟xkUn_wkUžO' zEӨůpݺO:_9i=Qk~[~ǓNtMd#2HY氃 G8).Ed rv3čBi9"fc)tZvށ{ח@1k=JtW_y?m[[:Y3{#sוNB@EKOp'WI] ܷ!zO=f`>ΆYTGx!0h?xabFGf# SQ'cD+J0;rRTS.א$sLbŤ{ʩ!?728guaV-h8ejH$~1! -/COi/RQ2,.KNB giR8W:tL Q@ND;d#b# |] iIBPhTޕ*eqUhr5&@HִP8vꭿڵw~=cdEHY斖2LLQL( a1;`Z'lj[x.$ǫ(d| 4"E^A;=,Qv85Mm;u [Zl>h8sb^ArK"ĘOejb G ~rr"hUT`K6k%e;\RVAȚƐH_IN$H ! ] vݐ2*L8"0y?[$Ǜ&ݢ !`sXMKr>Ʉ# t, RLۧ.`%NddDak+I]@V0\'[8'Smt 7}I5X;fyG^؛J48BWTw1 XVY\@ՃzOM_X)ZGژh۶λ߰&m-s#뽁ŖeDq40#@AS/MێbQKYڵ(l #tQՖ"cK\kNg_g W9 ab{t)5%D]'#Z|•((1ёx weҡ8 [ r WAkP`aUgWD]{֭6и;:#KܫeqIlD)ސ:dq&sVO>1!*% Y #̑h~> {< АP~#N,ʠ :&񜓶z󓱣8D>A>+cx,9[M sZ anŹDH+)s;I.Q39ϣ'Y3!Ʈc|r $&3dHq%3/&_#3 /94TrB&;z _34 N1R2QwFDIDDP~zCwV7l?mׯpMcuU[GמO>X4;mqm&3;җi'3DW^yYhL+Uv~_UM]m݊Z?`? A~Ls /3v9i#1%l؁20ȧ0m2($BK"%>:9el"D*0.'4-hTiGs sC3r?WSe'̑+0fͬtF.0\WiÎnr_^ِEt^G %QoK==h{KOth%ivz]rֲL\ڎKv.aN̦~% iB=4`F^?n\K^RiiGY[z ^~jnu+ցB+ƣ#V^.R+FP ,6 u6h+Q[f\hıiu5a-\Wx]U- =S/ uCL?x" = 'mD.wM;U I.ҖyY lw ( ƭ"D01vֶP87?ePe彃xTE#XD'nYU,!\2G/WgA-@.~7\";aZdQ9@ DTX9[{d=Tj*CFlYohlkQ ʓDF'En#s4xj 8mS+m z[Q`Ѓm_0s6-ʴQ |~IY;m#UGPeZB 'hL4?zlEr烇mc6ZA H) MqE)W~VI?p9v_#ٖT'?& Ă  5VRz2zUz*޷*1QY( -m<9( oJ[pi7 U?]_@Ldێ#; C,jPD Ҡ?#T Oh"Vr͆0 ;_N>qQm; z<=-ms[n#NJY z#ܙU~7B!m}=}Coos{$r(Q[MNG5w?*}/ʖ|!*݋%MD;GtΝm{[ŨCEVGp<*k fwY9]""5:\[t 7ypo;?JhMs۹=mٟFVA|!xD)-#jSj:1N)H>B@Penع-vBp/4ܵtk)`Q*arFNߎgڤˇoCҭY;Jp,9,sr5($af^Y3a%:J5iOhHGCAϨHB"B%U{=,H!򳜉="yFܧ^) D?RJyqy:HR#HrO顮J0DWι,s=d8TKywlmO'ȍXC <\ G@iE@1C?}#HJmTO=xP)P=iUU RXD;#OFimkZݦiP)"mlS)B-Y )@6 "}vDd1.,H+zvY뀀BcLQvAx4D2Fx{HD>Gڢ0?5 ,ٹ6P;/FD`֗eւQF"4wkD>P)::ۺQZ) 1P3 mֹP֬MykmaBֶD9[(sijk[k[P[kIGrGhJDd!zE>C!#8k\a CZ뺮۶m۶hh6Fc c\Pkv<:_S"z%"x07MkGsss`DT~/S$>ZkcFQ4eYx[xGY9l]~~~7M3m1m*7(\W:ܹoGeY/Z[Z[׵wQ9犢Fm.JT'EY{6"j<@ke.˲( '(Z[U="baa~aa(J`ЇXŶmeY!!#TXkpMywޓ'ij"ǣiBh%]]ж"`02FDQmz_Uѡ&b(dA^FDn6Ƅ_U?Ry5kǡps@mk{ 3Z˼R1@~=,ą 꺮m-ywpnEeaGԬC. k[τeyFI|nN?<EE<<ߤ̒7(AT^ƌDR@x'g5UjF~ utf9|a-83*Yq%Ñ(^v("ʻ_Qv/4‹V1bImۮ\1*ӫ*xC&¸"YPkb% oG~)riNy0  LzuKm3Uaz _{҇0޻|[~t ݲ,uZmC, Ӷ`]EQ}_>~zR}x]"jUJ!_|{ԋoyw‰/{1ߌ=A6!v駎-"jR/[^O^p{Q:k]vL5C|׻O:G}1oo־mR0f]Ow aD)8!|yidWBubSʸ8S| jdA}?8"FJ%vw K_;! =&gEQj7n/xm2;}uZwܽ*._SJ;ۺ>Sr‰'zʓun|=D:?oÄ#!pfRǞR7)zaK6oI$>Ȼ1;"0, ye&m}[/=~w~F]wugLc.7qʕwm Q]_p|ӫz}/]'xxjj4LSITP)_ऑQSX6?4ǴISڅ9`(UFք|9& Bo5P<&MXs+G#NDQt># q{9Quz}\{E?\3TM0ZW}gگ'"b8=y77;+f镫[ BYá88v^>1KbfUy-S2}a3Ir]8di@f2|(ޮ{[^0=b=} 7Ph)z|u=~.+F O9<7R0R<Wuͮ{|a_ek׮=ϸ[>mݺuzfo w?p#x/%_x}OGgJWm~/~sy~}u?X/}l[Zk]w{9y\r 7ܰnk+?ϐk'} ^uUOMZ_?|;~]wuu]?I|-Ї O9=y~;s_xu^sϯ^~9 ^ R|/^v)_9Ӂ#:檫gÆN?=o{z.SO{곟|7_/[3uL!CS9N;knB ŨK9L]64i8.ndY!q/hj/yV'@1yVַPQR'_4>Oxz,of4zV׾ֶ/ijz=mg> /Ck}tI䧎8∪RCdyrnW&)%t#EV- BIm;j(TSd'Oʜ-Hlr,LLQRN`<,@g(Jk[./:y֢RFthOP)[n馷/Q]/}^= Fvw!*aVBdqNT\2@2]L- ˥aOB\2 l-2l*7!Rvwν:Ǿ-oލozӛwO>I{UW_7pʫf8O^[v} QivY[Y9ڴiӺu?`'׽y9䐲4Vz?|[|]׾mosѸy㟾_ʅ^O|O:I\VpV RS7p_]r_?=ꫯo:n_9i(?Oo+_=yg{%_֭[ްozƍ]W5\7|;_Ep^#xnvM\+?.:Eמw?mo _Wkkwl޺n> LEnW[K-)8c/q!!9hŋx̹CiRC'tŪlj"'s'vJAStGx2^egJ x:L ֺWfV ^,Jh\}6>Ox`8*زe?cysgffڶ"Ѡ?w}i˲46,DJƹM!EQc'\.ե vFDWm b'r p<ʲ'AaSd)%(!t'2d[FA4#9-)t70ǽ^VkUo{+\|UU5M]x<^\η]/fN>33ֹ-[Yp8غu҅Ro]jf|X%kbFKOdۉ!Gfwff@ )aAw%E-=99p̪ tQ զMlܸxӟzƿ|v4MYO|BU>q}pqavM7}Yg=h?񚫯]j'Zh<=xvK/pa\Yz춛n(Yg5=cMweeDÏ(|:ȃ>dUGyT]7|n;~|GzSN;G wdJk]rQGZk5Mkvu׳u֪5z)֭;ㆃxȮ{uÍ?\]RO;W}xA[w 'PeUnZgM>t!s$+aBPhK9@"H dqhs,#L9RF,,f6:noh1nG 0pnJEDzM~mu}ۏn~ްbz㽻6np'}ǝp¥^zGX~}]J,K])eHAiwb)\&"Dݖb))'`bZ- tN%ZyeG·:.'ay@k]_0F۶Zχ5}m蓟e_g}V^+k6=6MagsëWe|׻vm ;C~R, ?J=1߄!3k`W}yRQFik&_(icfggwkzyq=.g^+hA;7X 7wso{}~K_:;{VX+8] xMՓ|We,TU(<(L5ܼSf~nSԠ?`8׷n]X8;_bŊAH#(T9u6;JEe[[BP9ܠ޹UEm|߻+G{66Q4Ma y:755U׍e4*˪N?W'>񤗼}Wr {ò^ϗH.y$=e=,mT=x4^1=EDhc#@x-_}fGs_veOx=Цi۶y쳟?~Z^(p֚; ;a;؎ B|ɰv0wy*pBԋp0U"{zG{/zQG>Gk3+ԡz!{'vq.r%p7Cpk"y_%,1sFܶ۶.Lv]8gkBG?z嗟Dok+mo=9)޻9ue5Z\Ckgw1o6o-oQCrF`_ٿrs(˦o6ȶ]e48[ǥζ,ymtpF׿˲Q@@mkBkh$E@@H\[YZԈHm=S|K>. ._ok[Z$$m]Z/*5zgUٿ~[|3|+vnM=~҅ȡjںԸ8DeQ=_\{w?ֵvu\uq~h]SLOw Z뛦7UhӶ|Mܖl@RmLQ9W](6^U' :GWEQ]FzÆ k/_{GH+m%*ERF@{N  jH!gf,X( kk}WFz돮g-[7;D\@xWYCY֊j$g{~k[ \߽SO쐃(=/s@ue@@y5o01PO? wm7fR=_s>ȩ~[o6ga 'T:Qϝ7wg͞3LؿN;yEcf;̌QJHovR瞽=IlsOZ]ves+f̘1wKn~l6+7lذl}ۯZhk~;:n8wGE.[{*ѵZmڴ #thb!@ 5ZkDґBP AXRz($ {B(k@`!A%Z`-AYGSʚƭ |=M7P#ɡVz y@ AahFdFADk HDFAJDK#֢<(o4sH+DA5!Y)dB)l_'W_ve3z{{F%I)gBi?*a+A@ uVKϋ" 5¾Z}K/cfB(51"DF&!30<)&o~B  RBIxɺ;k RC!Ea@ߓahzz{hhL<~7MT6S" yJ );FB $A;>  {L% eRkEH UMZ% yzR[BzRy}D Ri) @(PRl-*?}zS 6V _&TYcRhmT( F#2FW*@iSRI6lm m=R UzOdQ(`!!=1B("7j&$ %_}uPQz+X =VXFd!Apd%RD*hKkk}Ƹq}CZҍmEl+;dvMR6J_v![M*ZN:=@;k:@Z% 0P[ dPy!JPGL hjmppLd--dթ^.~ L̩;)t'c@NrrLP]d^*.w“+kTDF{_ )tWUO[`H! *JPaM=!1j^oV*lEVJn!2#˧Gk7b,[uW;ʵΆ͓ɖ$ffa,x+Hr[@d g'F⍡=ȅd!`FD!@   ѭBD"KĘ:qvD,D|{37=~ srIfNZ6T|[P=cX5K {"0;!sp̜ dwP33(ٙ !"JɎi !uve, !P#Z  b-+!1>A[F(.LhA $d$$Zb`S@L D@{Nu@2t `- ,Q0iJ ֪8éwd;3 &!%K̞'$ D$qc<Ġɺ5)%HAČ1B!35R @%V_&Nn51JnH B ˂vB9}f*2sU0ݥ{S}Ѕt'2033dF d- RҐ%k& R)$jfN~uh V;z66/OVz8 Q!h6R*$@ (4kb) iS3`F` Uk+vQkoYK I {F @12 w923HT O h0Pd<'k5Rj#@ =X+$k=Rn;!vcO3V"JIcBalSJ ҖXIB[ADL t2NN\0`Y̜N|T(BLHd2@FRX]DJsYl4291Q1HHi"@`$dH[#1'6&Ym9av|w EY0['r6 ICaY2r 9E0`Xf[)RDIDJF}zuSW=Q"(d#7n})z~Og}{!J q/A$ &&F4 4M=F݉&N@! = f(-y6HZ#-TTo1&zuc#ZzzjLRڴUKV7דf&G!<x[Jr۔$R1 zj5)ƍSS6ׯ[/'N*}wٙY!ub׮sy$+2PHΙfJ w)O{ k̡,#g_r>@\wiK/lL2'ۮASq1cB|-3}.wR}޽Zk`[]ꨧVg>;YꟿիVGZ|8 @ނg}HH?/s>w"UWw3;9TI^su}K U/ח׮֞vi;0G' i @2)R{~1WI>]FC1qDd^_+ݰqäI `˫qܸqJEyB(BݶwՇF_T0TP`dg}| -dW3NhѢ˗Yd )╨eZv^:wtVt_2ޙ)B'; P>)PFˌưزV)"EZv^Z"N12,EXDtK?ӟwun휿??b„ \se}F.s^~O?}q| !"{Ŋ05U4en;idDk¥6.MTPWV%>oFzJ!(/MCDKMΞ3뤓|ᜯ|_|qm?˿ǿ/SԱs'ҪO>yҶ˥~h?wRD$;[n׉DWv;-xO H`4F@ @KL084ԘaW^ 7l%K>W7>{q{~iӦ3tkR800/}SNm?ǯ_^2eW򕞞qD9 nZ|ڵDg9sٳF} x8Z?sZrx twm1ɟRL({K)>$!qLb&C=(b+J,4rJ[%:mMUٮRyZ nSBkҥK'M4o<)宻Eѽ޷>?g>kqNkl61ZknEzT!d.̽j{s<v-;U6^nقE:vX3֋)ꥠb,NAAm$PX6Z38㤓N?nݺ~'tڵko.Z.]tv;~O~zN;$ㅹ1XkWZ588h]z/ǟuY~nO,0yg~rJRi4A4Mݸ⋂3v)_ dMFbݫ,0F“={#6-e&řrs$rt1\tE\p%K&MME{4;39G=Nq1K(aiٜT4fM$G(߉P'/mεַ_Ja!g=WUNt\#:uۿs=?ĉJ}֬YOO4a„3<ӑ'<2P\hu5l?n0k֬ɓ',Qq̼;i*bs+]Hy+:ht=obaiŸН[RjhhhӦM.ZkLAJ+⮻},X1z1cu1l6M)7nܸrJkmE+W?~|___Z}' 5.Wl*?Yf^{e]ƍ~K>˖-ȹǐK)]7d2|o<<ϻ^HF9*kl] B^rhŖ\LTl]zS1}3g.\8qDD3g;Z3gΙ3'A#~vڇ~xժUwG4iҚ5kz+V,ZO}}ta D,x[C 5oT:g7r3"Tl,Er$gw*X$75?9'RE̩^`:-p<2ʕ+o+V<'w_׋}>~O~sέT*SO=SO\{+pK!Jx.`T9$,*TD)V4{]u؆OQ i'sbcyg}vܹCCC/rOOի~+W'N {YbŶn|fҤIFo~'<NT*%6"-^Y+-j!sT>2fx&U=؊ :n^44jz3&Nj )1nnGu.)&.9 x:b( TR,H#3k}w9}^ م]E9K)bC!W"p^d9B#9lNJq)H3kEVƘ-8_B5(11nܐԨDQ^jxA~:t1?rN: 11BjєӁIIE̖@%xH)kA%(CV)ZZ)3)-Y!dEQvJt.SZ4gr.8yR#?BݩE4KҜPjjE1{h4R̠<Q%BDRÒGVKH3,Shu0ZsyrAlJ)" Lf&fWZ묈5<"A*F^浘<g}qd S, )M "tgݣ t;!zUӏȈJBIfa$[$$d`B֗L``J_"3{/L،\ɰ9wT8'%ٰ v$vu>,R$v9%ٺVmFR Mo]T]FQk4FK0@m{u.Ub["d6byF(fȽZi`݅G>BbxJ!#fler40le K`&A%ce?;*"q]yI.y,vWHݩk;C@S7e4Gh֥Z30D(Ox*Ǎk6C)ePmְT|Tab{(C60vy!-OT(iZK$nWEilFLʗQdHWB ZH$oa_;b 22E ZEXnk$(Պ֭BDeHkw[׌4R۞NJ ۩}[zGHufhXmmfXl:2[Z)UFTiיTBc hA#VQEQJ)`6 hN渆9{KK[$n[h1~/DD@m;8yh $7c[!e*6wяN2MogYIe9/TS03-)1V_ROm'#zgJ%X<֯{y Q )Ϙ51'zk+7j=/{ `:Ҁ" n.i&8)N/7%m#@XrѮ%mYoK<6'K !()ß?j~9<79C9kL7(7=/|Da(k nUꕓg >ujYIU(B~ 츍6VSA]_&`Fa: P(ꚿ?piu|_ON:Ukr_8 .#0.m< ߯zbL`lSpZ3&1d'J|M}Nb[)l[Zt~T>VSI85l%Q[ji_3Za2J)ᖝ`>%]ۖfo+H5OFQ[k=OFQJ!0˯:O mՍ>M6Uy f{cW^ꗤ>':K;Sj;J9{9\F ߤkeBʝƍ5x3N3s!m1QQw߽y}Ͽr\6֯;w 'PJ3 h4yz)0aȮZR^:m*b=k-"$<Ǔնns)ZoA3Z05V> qĞ HZd9MҊ$1WnGāfZ&";F$*&16O/#nv/alY0[?ksӮNXE8$grW\Ͼ\>' q晿կvݻˡZ y3:ꨣΝ:,Wg&nk8 խH9ISXa|AMq vm%Yl-mhZSJiD\V{D16uaӦMR^|%o6 g}A rG{׃:8c7i1]7 P,ڞ\2rٙ[h9BȜFV̈́lLu,srM5 Oc^\Ni3weҁ!d!dLpC濖J%nvvgI N)qKH\.9i,wɀ(e$~6$S](3g0;SMRHBr9(Ħ)7 %Qk6H^f ϙ=1cFZ)ک-!mIg;23WHXCp<MZ\ں^,DqsBn1mi8uk=M&?;Rl1ҪAAO!H|;`"^x۳ٷ|!>no3p/ΙuՏ|}5k 'NfӍ O-NZ2O%$ޥEKmH ̙ c6QgR8[6FT[2M)W6Wٶiz2mXd ^oVGqk[W 0}[n-4x?8X!2w%KA0a8%<;<&*0, R2MͩB'h7 )%VtӲa(o `d=_pt{S0<ޔ)km`6 cܰG{\pA߸WZ%b<-[쳟skM;@".^? S6a+Kja#WJ6B#W1"f#gt$ƺeZxϟ|[JzUēg~Z6uS>K.oWvھq29zף°K{TF2 Kg7n•X0Į߄Rd裛7w_wP/ˇ|az)ɧH~CpYxC$9eDR Z3&{QCK/{fd-7veqѢ֭0#|GxW7;3gN &`Fd`B(ML wA!*X"(%͛_Wwq_NG'ŋ+_{կ~mwlm%&o;YRLFDa3}Ϻk4I &+1؊ፈ>I `"_JV06+V,za= Icl ̛foOmYw}_ɓGNߏ'mG7.6,A|c+oM 8lJŕ+m&M ˗_z?}5zHO/Zbvsf Q  `A*1 Cb*CGyvV}(%Ǐ=kϮ每=#Pooիl瞇zp΁EzҤIz; _SL6Q-o` 6xn Y ~nŊ{,GpIկ=u.gɌ3N8 8S{zj{w}k.LAPqJ@D,ZIy-7-_{ooW^9{BЩ`_ZuyO*%ͤIwu6f8Ν;'&txOc?u!Ͽ`(Ï,i瞞?3fL7ou˞] 3g^nٳzɅ;-T:0^}晧 BD:}0h m  ^`QJn;y)S>īyEo<#z=s֬yҧؤ`b:c9s"cZ 5BȰ}_km}'6 b4ѢEy0lNnvX?x^gf3{=cC!%w1=2V H $`A;>{hP7 M^MŦh'D`m" HJr`Jynկ1Z;Cl{ @d-= Ω G% `'Hj$gGCHt-dҹc* rrUCS iN]j̓[}8y7l S3LΪ1=Sgk?PvC6`\"uXE|NZ v*d)qkIね)؉-^w:i\ȊB*Ҧ `v2+Љ.N 8^II`L.nu("+d@@СAi^0- !ܩEo,V>| .)Vվ3' S &S0(mI۠ `QN_]^Aʡ9KJ>s}g4kuGT]w3CNTԆNշטU p'""r7ԵA\g+JUszVLiXBv1Q* '%ӝB3E1Bh 9 e[PU{jQ-煛0t'(&$ƚ/<xyM]LU)^l)Ů a|KH;@WiuRw"7Mx:f+bh"0;\jQXi+C+P& Xӂ@ݧ"A2[b`l n_tL$uA+]ǒQ]_|}˄@Ee`4 Ԛ@EOiJDZ `D"`bm]bv~W^z5{ү^ߜmW}Ј$ H*1NTp;x=H2NgkF "0 m * /@h)Y eJ2q{ 2ɖIe - ~ZSw.O!wHN66IÔ$SEçS I+PDɖ@[zj"I0l"x,0eˡ|dk(0*i@eDvi-QT-r[#٠I:dc  1Xk-"H " x l9dC-:w`UV$ l2"vp^fB½WwgưRBvArϻ{VQ;RVy)#ff)df!j+:R(% +H+աFvցRJ"xF[Xe ck `"22` XJS$Ffw.3[D`dHi <h]m"BDBjjF`CHDRCkY*)mu ^$ % @ҡR̀`-6/4}dmZ[D4&B ~x $6MIZ0lZfolf{>#5#F ւkٶdЍ$ Ln @~{Сؼyw3cmg}#`6 ?,s={l4ƒ9̌lY_?E??8>-[sO?!o?XH Dq]Vll$>~4ܺ,ټysR>w7^ku=׬;vuDy[CO,Y"?GW(WնDRxܨνs]viNBx̶^{{w֬YFJ {PmSG1~8G}Q":CX^ @U3l Eb,bwSDff6n"U1hTz}hb @$2q݆ Z`e@\h\ 6X6 mmz(4̡ĈOR^^dIX#Zg6կ?!}wbЄ_7nFm~7!kK/3@5"F{M*6ٯ$I=0"ڄˍf_<̳9s~#Fկws93T3=/٥˖1{ `}u^x1fƍg}aFtF6ߦ B2(ſсněoo~u˞x+6oO| x≽렃Қ-f?-yb>rÏlܸCA|ƍ|pB03]7ӧzO<V]ov{;GM4ippp'O^poh4w5͹;v3f!:CFzta8_Iėpx^f5^` /<Ohs^{>>ǟxꫯWZ(Ptu"ZYmْ GL/FR2ò-_7 z38cٲeR /</^\T-^kC;cႅW]uwsνJ|i4Ƙ~xΜ9}}}B;}Ri==ZWs+|ۓO>duV3fJ)}wׯwBJ)!رc7nXKn\y^0 ]z .ZhD,JJr /I}V\ FR R:N?p;[h(< 3 4[:Ea:s[ЖNe;P3"{o!Nn/r#96{e]{|_\|3?곟W^yG_o~/˽[hPd%Fw~{^WZiSOk!G; 4a%a$ポtdu1Bh6mrM3cuN:o~_|կR솀RMvf9$(ڦ%Ọ;- R.geGSO,YÏE?fB3OvOR!""r}^ !!^;fOOR*- ȍyҥ_sraJ)c=vjRD=uRd'vLKsEa`49CaZyTtL!fs] Y̔M3ܢ6M0yo\.Ϝ9SN>Os1s " x￿֚\:uĉ|}Z׬nZ:ќiT JS-QlJ3+N/"]܉NV1!*.=Td;A1FJ̣G^n]٬T*f3w޹T*M4i̘1,4iҚ5kyTueɠʷ%¬'-:1f)nݺŋk׿\0aŽ;x뭷Zk7l&!Nw]wƍB3Ey!@g*]-!'_84  jZVN=}"8cn z{ pˎ7+˳f6l8ꡇ:wܳ:kڴi{iG+8s&L0zjFx'N<3O:Yfqw{zzNiV\l6}OΏ<ȋ/㏟0aB =2".T[&2aIk1ӻI[h|))̜'/OvNE  0*]HdŎHaxW}ʶXE>bOW~ /|s}Æ {qjժ/|͚5fsgzzz$jVCġs9gƌ Z2n2W3)@Oj s%%w2B>i ԒS(BWH9Vke e˖=sr?O6Ow;iҤ 6z;3sxM6xgo}sz: iMd~&w$sS4ŖZ̉˛M3dZd4 [&dF$Bi܅IPBB13)a-UJ iHD;YT 0PJ1IS"Xf"$%$_*EXA`3WzYB0a$D$ɧ;Zl[)j-$R(Z}@BJbٖ@@DdBF#Xt|lIO c Pk  Xmү0-0Bf KղFExmBK0"0d j  D&$`k RH":H  . ,;5K^u.hIhn}OtBSf >p#DG? zR10 Y!H2t&; HqdKKNG%AOA @JNx5m\D@ -0 JeF!Dd]K:@pWQp2XD! h#$1Fྡྷ)NκjTjx֤EFXކI 0x§HAzr (rь("@aL5kmJ+Uz7o,R0 {!""hMD40-8ٖ]:T)KNW*jCiv}8]㉜|au3)][GYk#jZRJh4RJwѠz\.7qp9SZIc2+,E@r3es,25v9L]gYhGE2^ӥwEwض[w9^ d̈T71J)ctfV+F eLB0 \ p WYcTEsN-ea]є#  MP))a7 ԥa)ֺ'L|)C:'7;R}٨7Q)I̶[@Hq;Pptlof)̏>)o3f,Zt=ƘJ$%5ajSem,+Zk ;N;S &[n,65ﱩ6&r9By$ǎl3+ '&6rGG[ZEI$fP̥R)BzeBRJP\(V.y6Ƃ{A rI F3$! "7'4k$t8RMS!Ex"HDx ItsfȜ|tZ14ˌ1SY%\ (ia 2 @^qG'e`]T IA^IY7J>H!rlj !ȅޞjVZCFa\D(qԲq&q_38s;|ʊsV˗}]ք} `x~8800+6m>qfB ^z%'|SL-(3x{-5$xMW'JQV8ʻYYc6奌 jtrQFb1\{eH=s.$6̹V RdD#5i[DIH_x x1u@BsK EVn ;l.\x-4jWa}O>3w/T{oӢN$L'(=d"HiT 0 +u{pisMws"pBE ayA!6KQ _[wdlpT$s}L3U*Pp"6DDpSY ,sf\.e]oɳO2eRVYp;Bm1 H-SI9tm ԁIHܼ֒A@QhtRL-ȍ]a+C۪KF:K.O}F=BWlZ O )Г =EB)zJcY)BdSH \vܹ6o\k ._[^{N}wyg4}O쉒$AHD'{ZȓyZJK.:wSB0񍾈]NJ `{{RZy !) i-꿃26P<m-m0aqSѺp"(*5F!.;)FgK3 $Q&ظ!v*PjsQ9U=gVubqK X0f`OĻ&evw?uGN==~=ϫV=׿wv)?2Ǎ'x%_1cO>#ivLD7ĒI$+1%l*Alfbݜb5+m*¬ cSuxLƜ0{sh.AY5s6SIsDش٤d92q8 $#9ckz9+W~o>?ryÆM6?sM9~k׮Z?l?kjn cI}7Ii;#-cH{E33J$ I(k~IWՋ31:gѧĴ ]F,s]eίsBGT?sݧrjŋo3kwyG?}=zg|bW\?Sri&Mϯm6׬Y|t'/^b .'!J4#߷[w穀uϏ~+Vqw?٥4{S<%o3^o<䉾QOa| l>O뮈W\}ܱ3֯}=[ )B$+ډm"̲e~ӟ l>eGgo{Z?c*u!JlF1t_R!ĘwJjSc?鴷NY8B%$S[7Qeƚ~[Gc$VJ[ܑY{ ;/(5ٍzia0'b[4]!i2oTo__ڻwyԔ)S֮]OqG R|;9']ZbQ$07H Jԑ&| OLM9ԛXM)sW5\38X{g.zgn~On?T*k1fE?aq>3IO=duw>xϯX?>?Oq᧝:{Ӧr3g ǿ[a<#׬#.|Æu~3Bʬx` _ϯZ^9}g~c+x~BdZ5c.A<$ŭ61Dh4Ԍ{E"m'"(Jwd$E1~&؁ rKgߐMGq[bkW*r*H$骝ڍT*=S>gW~ի7 \yŕ]E׬Yҥ7m]__??`03Qz`Hm?G!/kEzi}ciaNRVf͠X;b*֔m0)Ș8\ء0o-ȹ?2p# s6(rdfxرzj1cYJQ*y&LXr5O bˈoQeY`쏅SD0ҡH9qXH e6Ht $rMJ1z] VPneloaf{GJw?a8s~Ry=s<)^otϤo1c .JcO,W۳vͺ; >p?]zcA_Ɯ9tGjFmħ2I#ٜ)C ed%s.ƙAyBvhi<_ DRP@9?3pUc9 F.?~|g>kpp8^k#K> HaRF])ʆ!"0ل4y]s!fjiTeIltnDS f*JmB1=JmR 0[h 3?J^oJy+V'.RYC;/UJ(%fCI!A [5s̟]uuk|>O]+Boo??2kP{Rl6˥bM8r-Y~ l-]Qv }}@<ֲ_w}Ϝyu;/^)Svyڦ!Ձ:oUN82zaӥp("^B-REOϛ;sܘcfoOѳ?O^o{SO}ˎm4x7G %;{_E91OVaΗNme,e8|w.N:D _8.guUW]40aoO! )[KVVqBbprDF[,GWn9j%Z@ `,[;mwAh}PQfYd A [uSR&,Ąqcvu/}JP0٨X$!Bc<%քl[o+9nÇZIY7z{2u;_DtJX^\ )h=O!XOR~i`FmPՒZ[-岿njشaqrk{.\r8 )DP/,w[Aۧ|Y0wB%[w'L Z`έN8Ѩ/[t W_0Vfzm{p;v3Yf͝wΫ/{qMJ%栉P)Y  @! `˥ޞ_|ﾫ_|{/ZuR& $"̜93 '~/ ׯ_{{mVqN2ww9oJZn̡o708=o\A[޲~9sNnjZ);5WK)y'|R w>@ڍS?_ȕ锧s'T]uǓg_juu'>/-k:U7| B^[NRJ*;ur}E<|c>Z֭s;Xֺs#B^^%t4˝mUSB)v Nn1[w3γ]x5\*Əfꁁ͕Jiҥ4ex/Zk;f\))*yZքa`VXY*Rt;4Tc8^wݜn>}g98qP??@<?]v-޺T=O?̘1w}w@,<∫{G/8m!-Xp=agLtӍƍ{qAwXAh/wԆj_4qw?G9w'z-_:+Uh}ެ.\+tZ&/<|5̛wiػzGE]Ͽ>}T (  7o>C_xᅫ;3g?;e);Ӟ{MKoZvyU/]z%]~ {ɓn;!DR=0`R ew]zfՄ>޹p{!Ma0(phhaPoHg#%#54|/.)}9Xp U3HfƂer\1)Vyf3JfˀZT1`dTl A$-/O;Aa|{i_8(} d&dfmlf- HHE4"P[@ LTk(F[Dq@F1dÏ`!a/Z 6 $84IX :CH,҆IH$CԆ28l1uB0 1 dH,xs?$c4b˴_؉wF[$ Flil4y0 .0P1 PMP `cS=o``Gg`f.0HB El@t=0FgB(Ԁ>-Faţc7`9.]55:n'9ቓyV8"RlOOexG3"h=oF4בK5ʀ#uRz^%?k `^}B&K@,Bʋ2$eG^ 5qܩ-:cjZ3$#3mގ'lD+8FJX8 G dmu6?hL;i!#2R )-Ӻkݍ6;beYVD۸ #j%uR[DobESYW)?آPdL46koY1iƳ+oy}&lgZ9}kɒjl94kZ-bs!%6„\D-Cw&K2Ԛ B;Кpm`в|~!T(3 cIR.Z ef:5Pʗp𡙍b_0N~_$ r19@@ʀeg}6zDFH2{b#"f-y@j=7͊ll_k1Hdk@k!C7HptmHDS 2ۡD&$B"%!AtsUQ:(OqR*!TA ABm[fȸIizM@j w+d7,a2|hS˟#| -!\YNzW֖ſZLlU;MphmBM }͹M@Q!AqAj"T P  H@v&ၢZ5kQ%.g!(;\!(d. |-Ѵ}{~ 8[ `R+:+"Q^S- a4Jm ٹ?pAcGm =oOwq_-j#áj(Yl%zݩ2__7K480R`a5D~AQZu)K[_ju<4ӏ aHH 6A(A D !(Ҟ5_m˫ɀ=TI;-]o}_U>.EJϿ7".x2$B%Bp h4 Q@$8\J0E `R`aGČZ\kʿ\aANv'z7[ʰЂ;x "BPDw2\9431d )%Ȅ/8c6CFJywmȘ}R2,bC!yB!'Lm1)Q|Fpf @k#wH/Q !P0. ~ 8q[F7 hP H"B_T P! @@AHƐ@"@cDeIF9M ^L!J2C|-Q 2mq)}&F[JMJIl!@0$ HzFJ#gy<BDR 6~5CdB6Bc/$2@lx!4hR*Uy{u &x 0@:e[@DBCZxRvj7B 0Ezo{?b   <R}m I%9 t=OY2 $!;O]ϕRѴ7 Y"2h @c8O-g)Kk-t;}ۀbH ! B P Bk{Jy iߐ'QJ)o<ҵ"ȐB5 4,N7`s BPKm%iMZ((1v[* p\U!k)i,eH i\ӞA+{n@B= ) TJ% Dm|)#P5CG4yQ)ik"pC`osQK26lABI@:N@@ |4n?aP=hRiߑJ&`!OF`Y)YBNw({X4K:N4QYJWk΅8!n$ZkiǃRRCC6E_@DP@׀!0 @ZK! o1.RڑBr }^(ҳk_DT}_A>'@DZ{B DCFoܴOޱ_Bo!}O-!0DDv-"Z27js؁eu@B zGH)ɤTR)g1ZTRH6 `3 @;"D"}CAHc eY|O Ttl$ '/D C4I˲cxA( H 6|߲ls@8tIJ@@2>S \`OT,A}*HDl+t!uMT@HrQi@ƸTNNL +dԒF,'&15t4Z[Vu9h2?F55%^NNT)e*q@djgDa٤N~B|n $s=@:>J!:t(0|c8ek)d"yI۶hJ#}낯XU;ǰu`xI"$H{Na]9OjB߾Ak- )6ZКwb $BhcH ҞvG~wչ2*Fc _KwF %$ TP8a,gݻ$!0L$PfȤv,xZk%1J!Y1 T8BrJ)m4׹i$@@[ ܳ y{Uک&@I}F/P)͜_V9fE$o ;8@@"5*iϟ?G ?{ϥ&u|b[vlcoݲ%8?򪫯Z}۶(|M(7WZkN|DRh,Se՝FIY_omԩ_ݩS'c`Ӧ>hco`I-TVi$D29nO?|2 Q  о!08W=$#@;GAvJ; o9穧|)^D嗷rK4B)Os&'zR>[쌙M&!O>$2B) -(9c)oRRH"V"DFdIvOd?;WA~x']ϫ7c/k>G=}|5^3q7'7F|lRJ JJ|51F.VQ u@@ ER"ej@ -}z|r d=.??RjϞ=%%RVQRRՎL&mnjjJ:zۺuK֊;4D.ƶVnYlI'IJ>LܹS!,вx566ڶ8N}}}aAaaB@+X'}ѐNj~hó ܆|7?7빿d6T<4?{c (j"C=>޽{oXN쪫}u{%"u}oll,**x<^[[+,--ecu]fX,&oɩS#P'≽u{srr:w $7tݻnjȠ@"?{w^3p .`]&OQ6lpgN!N;։D:Obђ6A*٩S')vƜܜU;yٳ'H^ )dwxw}׺u6mh@sVƆ=53K,} /0a¦M&O,;9Pkjj8ƍﾳ>>o[YYoѽ{GK/͙3 r5ضG555ڵ_~;nʕL8qС!C$4Yf[__nݺ}{guٳn:z+B)uɓ'8q '/[oաC>}(% 'Mtw.X୷jjj*,,[KKK_z5ktqݺuhb>x/>6Ȅf#f \ &YFR%[_O(4ڶ 2D"u˖{??@c4='7.""˗?X3?_2444}Æ ?~RjΜ9sνğʦcǎݵk… z-u|uc}h4u^z]|O>d]]]Ν#8S ~e=0`Z]WTTDSOevp~E"7N8G-++,_tc=&Bw޽{EEo_\vew^SS7|Ǿ?O k?sss%7-O"K l7Z7QIŬȥA믿+y$d,+//fs_k]^^yމ'7bĈUVu֝n+bȑO2es I'7 [Ӌ/0ac=gϞ=`oW^h4ʴa)P]]]^^~ '| ,hhhRΞ={ʕӦM,?~޽{.l̙]w]wݵsNqxm6uKKK#8V"~3ϼaÆ=-Zh޼y=،36m׿niӦusNNXbȑSN=zd2>!,˪7o̙3'Noի|3}={|MT]]ݧ~zL:sSN۶zju)-s1pd<6_l׹* 8<*\[x<0ƔѣRJkD|ߏdbƌzC={n&"CUUU"BXUTTTSSy^<=fϞ8N";wm~t3s=ӦM+//ݻ̙3|ٲeڵ~wϙ3bڴi^{mHF뺎㸮۷o;l!y`ٺuk^^"HΝ]sdzٲe |f:s.dڴiwy?{UVm޼y̙guɓGsϝ}َXEDs7J'=43oҾ(өb#2'KF=\-ki,**z:ucg\׽'Ns%I9!D\mjj,+tҥR*D:vد_^zd2[o}uuuwu9Ϗ7[nB !gوb1 R)ǾMFM<Quᢋ. Rq=z}ر`Z#<*L&?;f̘h4;vXhQeeٳ? 6رcʕ'tRqqq^^ }v5Jn׮]eYݻwӧc]~}CCw^cLWv > -!B^yFQ9  mZ?SNOֺpwyUW]o~zc8D,SJL9rduu_~YSSS^^~g{dɒƗ^z?nhhظqcݏ9D"***ھ}{$1Ɯ;wfgBDzJǀeYRJ6ԸQ, y7|sȑH$|?H$d!D4=>{.Y۸qcMMƍ_xm۶^Zk=bĈ.]xWRR8NuuuNNNǎ/BÐ!C^s疖rd:y80L:KS3Zri e5u+l]1cxׯ_g}vĉǏ_dɽޫ4hРAyW^yW^Y~m,RcƌYrݻW\m6o޼cǎ^xaƍÇݻy]vBd,/&"uhѢs疕u%|-7O>}> 1x]kD"๹rL&.\8p#8O?mll\pK/{O>1czשSZwᬳbׯo4(??5tm}i0a68@e&-SqYW,fb6sѨmۈf뺈XWWt#Gy[z999z[ ,̙ӥK־EEEoȑ# 2k֬۷/[LJ٫We˖SPP0iҤ;RjXp+"J))%"c#я~Էo_"*//'6oܳgO[" LUC< #H)xo@N4#عsg(,,%t]=0-zĊ+?tek6+"z(䒬lI+]TA*dFDOBm]yVt,G<~v%lٲ裏frض]WW!^z>|xiiinjkky:dk*x7^u-[vJ4SN{ov;NZW)y̙;OǏz'x{aÔܕf}ȑUUU+VXtiֱcd2ɶII]wy֬YL&Y9K/%nSO;XAf%RjM itOo++C3L:fpWF ,qlm0޺uym&Loz˶?|ACCCAAA.]rssY!CYt͛G٥KUVyhll|?Cq|ߏbd2я~${ r}`bU8!DAA-Ž/zĉ„O{`9⎥͘1cn 6,Y?eYMMMq?x6vcرe9Ò;|ꩧkvܸqNܒa 3^k&Z(B$!G`{5{J:tD@Vu%%%7ndn(Y(Gyyy~XsLjN+PS|ݺueqRʂ{oƍK,͝4iRNOW\\s)qFdcܹ3v֍}^Z_{_|qw5nܸ~㏟>}rDdI&|UQ(A~$1OڗL&Y3C!Njv[}sFl 88k3.ғ)F ӗy"GĜ;w  .I&-[N%a<1cƫꫯ &ۋZhڶ}駟uY_o1l0OymLhrI& />eʔX, 0{CCCΝǎgq/\^^OcufY֩ڧO7pC=LR[[Rf\Ƚ%%%'N7n܏׏1{Ȉͪxjm?e|oVچkX[hmQQK*^ȕ }`F1mB0c}Ƙ?shsy+++ncѣ ,˺|ߟ:u={.fiqY]]zs_dɒs=BGDqh43TVV.Z護bS?@tЁ>㪪*f2?O><"n޼9??˖-m۶ɓ'رwާr#?uGO>r3gZ޽_g ?]<uڕ P-YmȦ2>[_L_ƵfUw_vرk.Qu/^K/-**ڼyW\kʊ5k38q9s\}{9/|ꩧFշo_U)eNNΨQfϞ=bĈ2D=zt~~>yo뺹MMMׯ?뺮ijfΆxO>ݻ7;QөAvt ɗv3yٕݽ7y6B*NUu(./FC;~.]uQHĶc9߻w^z.駟^^^xb8㌼}>cwo޼'?I>};wbqQQѨQ|իW/gWJ5o޼+wZ3K xÜ y5;y|P0# (eY̋n p~]?? z Q/ͯC YHLy1>s $VcǎK.2&PeB4P+WH֛ok<o[Gjk ȶrra2v(µkW8l0fof?VO)()|b3*Kv}D;xuWwobvF +%ֺ+~7j(żĮEc`s6 d2OTUUs=mK!ѤR\!R/H p)cW* 1<#z޼y=k/<|GJ&{ܟ shP*neWB@ 8,Pض+cZ=!l5DE@"",e`9L'`@m4+imm[ƇTJQ#͒]IIR!DWWSN]D<W]uuCF%&4DhD'p³=e˖#8yBH>maӾF Jm*݅|Z7:e[٬N%5d,"CyZ),KARIq!c JJO,^4`#Vj~$ueiߑnz7|lԭ :uF1,kիԡ1yDWN: ⭬Z9n=?ҐyY H-,ҶɃ+hL/K=aaX^,D,F&b4e$1:Y޴ Hjb$EE%@DzױB4ci)"#BDlFr&ui_ÔoСJ u^ tW'"<^UT7Yc g~IwnE5ةcg!hf F[R} !n-N!(%0DD( nD(h}-mJꛁAo8 468`Lf6`&ľη7l{(/]@(B$Tl0*&L@J9L@a4} 0Q SdxS %`! D@Eh9OjM4 SOipa8 aƄ_Xٔ4&Elm}sLF" !H`@<a8 0H #$ _#Zk{ Q>{_84 AA۱Ara8 0q."AB)%۹1,H7%mv(IA:a8 0qgRD_I` JVH)0dQF+L 7_D; '[vc_@a< BiOQLt 1@>9ĮeiCDL )wvl}h֚UpB)8[h @2T%P9"ڷ,k?1H!F@(јvcP>Qfb.q!a˱I)cY֚#a@ăj=sQu7B(tJ)`@{>(IG´2ҡ}I$i㠶H?mIk[rO[s@@@hAWGSi|HXg;̸_a -YȠ& ۖ]_؎(Kq3q/$a4Rȴz)TMP/ɳ?m@AFsx+"Qj)Њ8D8ݷٲ>.jYi9iF kF *H; @RʈT@|_=#"}cY0;Ggollm%r]Ok 01 ,3%BpRy~?־eI]C>6[55ŕR`#Dz(zY15,ZP$I$5J?5W9/SF@ :."Ǜ(j}HܤiY"~o2Kr^jfv`Lm|o2QU|G!r]7L@9KIɶD"%];)B%ֆZSD"V" \z]fV_Ҩp0U e11Hy:*HOT"nBj"f* 8h4J#|LL~<+,̳,/\ņZD"RMP)CV7oͱ)Hr8ebFqy"L5Eh-/࣐u3,VHԂ!A3rni(3!3Y¬ bឥVךg"66oKҞ=JΈIb۶?_nx!b ql;HE )7%Gd!=֩RMMMumd2# udxƘMMI\s*XkNE1] ;D\aPk_HᙆRN "iW Nd4!'ERh׮u\WYV߾}rrr R_yسg>}z54Y;Z0dh1${KHDY$^-7D o`s/xRI𪪬N%=HeTDT蠨(k/36TF4B $$sv~{Pyos<7^묽ګ|ŤI>hocAsŊ}_sϽK`zQHC 1F@PSgk dv)m1R!mdg9ک%mv<2gδۧ74"{6IRڊS˴:o%mu V'T6[)E4K%p3!紘O]}Yl):=k y#I[(e<=ʔڼUJvO>9|Ï~fUUKBd!,$d>;B-rƤc2sƀB .8ctv-fgPVhPb8)9g6mR%3 ̶@PjFBpMɌQE#Og>A9T#\Bpߏyޖ[:ۣbbmIXcQ(^)QQn+j=>?5wVV.K";vC ;:xy>}R Bd2>}ZK|{~qs8TU%B͍ǎbi5 !eYE%>oGO65OLJ1MCU TU,\{`sܤܜ.$9)#vrΊ1MS[lSU]Jr<&6`>)Aaqi#GjJ#PS]PRZjxcMv'7'*,,R4]Sy)ssj9`̲ WYYr: J%B~OA bڎ6+YY donKuRB΅:tUI$HMv*|CHv1%ItiCB FL".xΨ0sd -=pj7s 0V6ޯ OL[QyvΠA,:;*BEUQ,=X]C u4UaNK@AB4v8\EN5W_CU4g0֋JySQ+*..!v%)%MJkk뱣uB~5MWb .@FFFl\#ǚNgC!M [ZZj^@C$.쵖 H ҈afN Mva T "SOݮ"tƧ}t=c$o޴y_,h8?oqr[ϧLIQ`hm9p8U0f-,p◔a9ojlt:MMG0k:P!i,! >8w)huuiHCmn>z31Mǎ=tGANy_>ˑ[NpG<xhCC]fffVV"(^0%NCig= kaee!"!đ'Ӟ;oXɥA֮]_.=^|@UVfFEﺻY@JZfuyy`*wT̂^[voٲ9>!1* 1ABaq)uݺ^}SO4h 7LZjM=?mvΚuoSS+/b~Uӗ/k}7oߜ˘kyܜõ .t:]ݶ}=ΰa7{ l^~5 s{j~عsF6ry#F@W{Q.W[{ۃ>;=r>D~KJJfqgn޴oU7xߜ?;w9曧1cZY٠بõ Iz! B.`ê?xW6߶}W^Pv6i.,*_Ud qD;_[T\'AO>}Ec'N?TS8߸qÍ72,\$r. ;n4,Rc;457K~ڲ`S-\B~r㱱Bʿ7\ݳsg{!%%O?vׅE%Q>B^TU1reLMDu7Nr3 t j9?eڱ/BzZǰiӦ/ =^;^yma|\;]Q7';Db+)*`λ9;bMOz\0XNْ]#v `$!4N:-]=@hSQH5c 1BJӦM9c:eB|ۮꊆc/33CU}p}>l۶nY3TtinnvuuMi3f8p`?|p/vS y/xfȠL+<++Gu[~%r;Wmeuu8W^` |>߼'{뮽" /{= [nٲK VT8pi;wشis﩮9ȹSn3fѣG__fqaQ\qŕyy. 橨|"ǾOٍYmLQa-H{! 4\) ![9dП6tqR?˨QnuG}_ qv=3IIɋ/()-;Q3I|Bºfֶ oykBb TUryDwo !jn~֭[*]>} UUofSSˁ*+_yeXmmݰq:!9I)ɽf~hsχ.3OΓRXW_y_EqQу:\[4EVU=<1 O)kljJNI,(3L+>!awU쭸[G_x\p}.RfuΜ9y_|G/uΧz򪫮AQ& T=65H,UƈEy睗csvsONN֝wݻJJK>}9szKkfl.|W|;n4a ă t8HVv˸9jԅo,]_0TU XgߝN/;]s$3ϰ$b{0H;I]֭[{ bh8p NMM%AE!_qCpMܜ- <4)׋/Tگ,Ӛy]ׯ7qƦ??Θ19sFZjk=rgHz"ᶖ|w \TX`ε@i^4v1(c͏kGE[ <)x(J0h0ƶp;[ze/xJtM[|'_~2 !=~[qe #X^^&C ɓw۷=#/,;;355Wb±Ʀ[Z__WZڏ2r裪'zNnp PUMB auuG\Ce"DH.rNOD` }|Jkر7>;;; Wh Xuj}O>@Ӵʊ EӤI LLIMz=M-kԔdct\0 꺮* hY-fgg|phy}AC-SJi{g457 80~xUU ++;̳-y[t:cΌ~衇.#GPo&!v! &)++s^_մ`0X]]k玗_yp?~ !+)2TmmQn A^^> )),7MqZߖeegee3F8).iyӦF˴NojjjJH߿Ԥq{CYl\Rt)eZz<9v9\޽3ŔqJܲ,ι\ g9˝-%%t:A#O6E߰G,k玭(uu =w8(*:az C>qž)ׯW!Q߾6mڌrs"/!!=uuuw1B*cLT0eeeI6nҪn5LcTp8]x}> h>~Hj`08jԨ8JYii <9 EEE!ECX{5.H܃sBȡCV^}}*D2TMwtxUؘgOy}]mc㱤$]w@HK5W%$N0ĉm۶ڰx{G{aQ9"|>8 N?^w8Ak!|c>rUPP@-fӱUI^G_S] $D Dh9.Yზe1zu {w#+J׹GI\p9Ec.zdC=6kʌ `pVgf5 ?aVlea)+*:kkmiQ!4 B0cT!*J RbY{ABHLQЦM?xQKI#猦$<*2dDRs*>  CP .ǍdɒoOFEE`aQgYׯBC])S]S )ea@H[.`GGE1[9). Hi;K1F0,Cp @gee2.0E1Bp!8L8!Q6Btx: QλB;fNKܰaz.!DԢsjʕ?X  B0Cz %#*JRoRBoRS0uMqC5Um.PbbO?m]Q!5>xvZ[vlrꙙYNSJv;Ͽ+WXf 9))99U K "%-EQ0` B1 H@0KzGy뮟4iղK?}+ BHJ_l=\]Ur|ܜl!̛fLxǟxbޫ'@^E?}~~b˥j?$@o5>ױcG}ݦ&a\SJ-&h?x7x F9 >۷[zecƌJ zN^;5M+sssWBbr}}oh7m0 `A$Bմ/Z%K[Z_4)yysH [m$ N !@ kV؋ƬZ²=KJZ8qO{{ZZzRYQh`P#7&-\;HNN9595`Me)  85j߾K&SP N-ycnj~g.F(sKI%%*Pp$<#=b.HCCRBBb|,AW_SPW!U*X2pLdסU)'1@ cR誂 qٙiŦ$'eDEE3j<3cǎYO HA`(㖡34>! `$8U` A@*I]H <999 In3)!2 #PWzA `,8kin\ɓ&=ܳ: IN RA FJvJΠE (3XzzԩNpF`3KUiP<|Nv (&S H~}AJF>w4ܾu-?{@J(CW%g{s vlGP0% W^>qرm-'[7; $g!T/}Auu{3tXSOL?r"7;;%9%595ZjM_xٹ=:p`rg@ fZi))yxQ۷ GR"(HJ}%9- F4>Oˉf#yڌQ2Mog459yǛ-pf!(/x͛?T5-==33#3&:.&W_VUVdcӯ_iS5A`ZI~eR1RFA@P.nzsA߼Ǜ[N6;B0N ^tц U v98)dZzFRRrtt O>y=K,~r޼ ۮԡi@(,';'̬ܷ~g!% " PОL@"Hpdk'LRRSWIFf?\woBBի23)coOḫ]g9rTKKKZZUW]EQ JJJV\Gv*}ѣ-Z{Qv;ow8qbǎmsMHEA>|ʕAصkE)B(*}׬tok'L`KRB*lf̅fͺ+u]ꪫ _x555eB1Z}!*FRk>(0 i>Fb>"^>xb^nN֑]

YU>zqׁ^O?+srrlb4t]ڱc_n~`0Fu34ƍ7x>޶(=\\\,$0MS5[bŊmڴi# bp(eee~: )Pɍ7p_ve/ ֬;T"P1:t`U!#F`LDGGϙ3g…G`}IIW_}>|A]9sߧ:w=vH||bC]w]kk}WZR2A0qD;jDn{HRs6zoeG8WQHJjԩS,Y`pM<_~֯wkk>9(y@b=( bWSC(p?W5]yH7dgn+?.6 F 0,k ْE<3~+¢t֟Ŝ.NR6?oCyyNqƍ.rƶonD4 SkkNgFfoOgrWзd.6-zw3֭]dEAjZzqQi'NطRJYXX1ڴiСÂ@Ձ>/:&_~M(,>[pk22zƙgϞM({-(ymnQ2x eƆ 념}i9RPPꞽ}cc عsgaN>mɗL"uZ]zƬ\)Eõ))%RJc׮R~MI Uǧhi$mim#PViaU0 A/zٳgcGrN&#v=SSs"~]cι 篺p$$$8{rrhi9Q.Xvvvvv.@Q!E0|wWâŋ].'BXӴC>|2=iEfgg?~<4 B~@'RSS8s̼喛1! QL"SJ!R]JJJ]N! `QJ_~pH)u۷c|˴*;|\Qդd]22kTgeF۶mPJJ.,,M:͑$vG\(>-^:g,NTH.Bp(AJteezzz\l֞=SRӲ}>-Ғ,Bw8ܶK0BVVko;;#3Qb_wG$)ۻwa23O̘9cc.r.)I|U5!B0]w`3eAw755ڿBB/ -[(eGG$$$TT+)3?zy _~ɓ)e;Z.c! `L p:tBȆPUi1 v!_Q!?Pp%@Q((iѤ^qoV[z#Ba q!9 ĸE(Ä@ "a$BA1QrUUBiʹ1&iaEB/KМG"BJX!I.30 ~B:QU!PB(""dB@cb= *..b)c9HBeQE( !L9WT ɘ@Qa9DB8P!B'wBƘ;XQq퐾@(Ę@$".%& ɹPTq.I!œ VT.8&$4!\HĴqI-UYU]]soB$ iGRB;DR E 2-*e\QI"DB. Q]jɓ!q .aWJTM ::K.镔BX1kZ4]B,TMB5q5)>!&- !aLAE!<"%\@dQaӲB /G߿GB B"DE1- N)#ƆiUU%P.㝻T!НiQLR!!P4ʄiZ(AÀA0fffx<" @D5"$1B )L!L)Gl޼ĉws! Q6 DE +4mt !#D BA$abB2 SQ*N.@յɱ:\WM @ ;C H! %fk# zj sǠ j3G8`DG$0(CQu>4uS{ㅣvG%@-H l3:t(ŭrq;HQ B0IE+C{pX2&sE)ud~ņEBvV茬z6]ιEkWn C6 F`2]f8q^"zABrfEg%_؃~"VnBtt.)i)/A)!z]$g$3AH A]!z=aPv45LTRN>#|MlNd.6l0/p !8(oWo+ˍ%B !gH  rm.ϥuHuaiaHF^pNmv[Caw))DݾOrg0<ݶ;> endobj 101 0 obj << /Length 13309 >> stream 0.271 0.267 0.267 rg q 15.000 29.476 577.500 747.524 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(pan-ethnic, participation rates among individuals of African American background are lower than expected, suggesting )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(additional outreach and educational efforts are warranted to further engage this community.)] TJ ET BT 26.250 736.167 Td /F1 9.8 Tf [(DuchenneConnect is targeted toward participants in the US. However, the registry welcomes individuals from any country to )] TJ ET BT 26.250 724.262 Td /F1 9.8 Tf [(participate and has previously offered the survey in Spanish. \(This capability will return in the near future, and the survey will )] TJ ET BT 26.250 712.357 Td /F1 9.8 Tf [(also be offered in additional languages.\) To date, participants from 78 countries are represented in the registry \(see Figure 4\). )] TJ ET BT 26.250 700.452 Td /F1 9.8 Tf [(Languages spoken by participants include English, Spanish, German, French, Chinese, Italian, and Vietnamese.)] TJ ET 0.965 0.965 0.965 rg 26.250 463.512 555.000 227.059 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 690.571 m 581.250 690.571 l 581.250 689.821 l 26.250 689.821 l f 26.250 463.512 m 581.250 463.512 l 581.250 464.262 l 26.250 464.262 l f q 225.000 0 0 170.250 35.250 510.571 cm /I18 Do Q q 35.250 474.762 537.000 29.809 re W n 0.271 0.267 0.267 rg BT 35.250 495.048 Td /F4 9.8 Tf [(Fig. 4: DuchenneConnect continues to draw participants around the globe. The colored circles reflect areas with )] TJ ET BT 35.250 483.143 Td /F4 9.8 Tf [(more/fewer participants.)] TJ ET Q BT 26.250 446.488 Td /F4 9.8 Tf [(Age at Diagnosis)] TJ ET BT 26.250 427.083 Td /F1 9.8 Tf [(Frequently, families suspect that something is wrong regarding the health of their child before a diagnosis is established. Among )] TJ ET BT 26.250 415.179 Td /F1 9.8 Tf [(the total group of affected participants, the mean age of diagnosis was reported at 4.8 years. The mean age at diagnosis for )] TJ ET BT 26.250 403.274 Td /F1 9.8 Tf [(participants with Duchenne was 4.2 years, and for participants with Becker the mean age at diagnosis was 10.8 years. For )] TJ ET BT 26.250 391.369 Td /F1 9.8 Tf [(Duchenne the symptoms were first recognized on average 1.3 years prior to diagnosis, and for Becker 3.2 years prior to )] TJ ET BT 26.250 379.464 Td /F1 9.8 Tf [(diagnosis. Figure 5 shows age at symptom onset vs. age at diagnosis for the Duchenne/Becker group.)] TJ ET 0.965 0.965 0.965 rg 26.250 190.429 555.000 179.155 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 369.583 m 581.250 369.583 l 581.250 368.833 l 26.250 368.833 l f 26.250 190.429 m 581.250 190.429 l 581.250 191.179 l 26.250 191.179 l f q 225.000 0 0 134.250 35.250 225.583 cm /I19 Do Q q 35.250 201.679 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 210.060 Td /F4 9.8 Tf [(Fig. 5: Reported ages of participants at diagnosis \(n=1562\) and onset of symptoms \(n=1233\).)] TJ ET Q BT 26.250 173.405 Td /F4 9.8 Tf [(Family History)] TJ ET BT 26.250 154.000 Td /F1 9.8 Tf [(Dystrophinopathies are X-linked genetic conditions, and in about 70% of cases the mother is expected to be a carrier and about )] TJ ET BT 26.250 142.095 Td /F1 9.8 Tf [(30% are expected to result from new mutations. Of 1,680 respondents, 416 report that other family members have a similar )] TJ ET BT 26.250 130.191 Td /F1 9.8 Tf [(muscle disease. Of 351 who provided additional detail, 38% identified a brother\(s\), 15% identified an uncle\(s\), 16% report a )] TJ ET BT 26.250 118.286 Td /F1 9.8 Tf [(cousin\(s\), and 12% identified a mother. \(Because of the lower prevalence of manifesting carriers and the fact that carriers are )] TJ ET BT 26.250 106.381 Td /F1 9.8 Tf [(permitted to enter their data in the registry, the majority of identified mothers are expected to represent known carriers vs. )] TJ ET BT 26.250 94.476 Td /F1 9.8 Tf [(manifesting females.\))] TJ ET BT 26.250 75.072 Td /F4 9.8 Tf [(Ambulation)] TJ ET BT 26.250 55.667 Td /F1 9.8 Tf [(To date, loss of ambulation is an inevitable milestone in the progression of DBMD, though the timing of loss of walking varies )] TJ ET BT 26.250 43.762 Td /F1 9.8 Tf [(considerably between and within Duchenne and Becker muscular dystrophies. Figure 6 shows the status of walking among the )] TJ ET Q q 15.000 29.476 577.500 747.524 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(pan-ethnic, participation rates among individuals of African American background are lower than expected, suggesting )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(additional outreach and educational efforts are warranted to further engage this community.)] TJ ET BT 26.250 736.167 Td /F1 9.8 Tf [(DuchenneConnect is targeted toward participants in the US. However, the registry welcomes individuals from any country to )] TJ ET BT 26.250 724.262 Td /F1 9.8 Tf [(participate and has previously offered the survey in Spanish. \(This capability will return in the near future, and the survey will )] TJ ET BT 26.250 712.357 Td /F1 9.8 Tf [(also be offered in additional languages.\) To date, participants from 78 countries are represented in the registry \(see Figure 4\). )] TJ ET BT 26.250 700.452 Td /F1 9.8 Tf [(Languages spoken by participants include English, Spanish, German, French, Chinese, Italian, and Vietnamese.)] TJ ET 0.965 0.965 0.965 rg 26.250 463.512 555.000 227.059 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 690.571 m 581.250 690.571 l 581.250 689.821 l 26.250 689.821 l f 26.250 463.512 m 581.250 463.512 l 581.250 464.262 l 26.250 464.262 l f q 225.000 0 0 170.250 35.250 510.571 cm /I18 Do Q q 35.250 474.762 537.000 29.809 re W n 0.271 0.267 0.267 rg BT 35.250 495.048 Td /F4 9.8 Tf [(Fig. 4: DuchenneConnect continues to draw participants around the globe. The colored circles reflect areas with )] TJ ET BT 35.250 483.143 Td /F4 9.8 Tf [(more/fewer participants.)] TJ ET Q BT 26.250 446.488 Td /F4 9.8 Tf [(Age at Diagnosis)] TJ ET BT 26.250 427.083 Td /F1 9.8 Tf [(Frequently, families suspect that something is wrong regarding the health of their child before a diagnosis is established. Among )] TJ ET BT 26.250 415.179 Td /F1 9.8 Tf [(the total group of affected participants, the mean age of diagnosis was reported at 4.8 years. The mean age at diagnosis for )] TJ ET BT 26.250 403.274 Td /F1 9.8 Tf [(participants with Duchenne was 4.2 years, and for participants with Becker the mean age at diagnosis was 10.8 years. For )] TJ ET BT 26.250 391.369 Td /F1 9.8 Tf [(Duchenne the symptoms were first recognized on average 1.3 years prior to diagnosis, and for Becker 3.2 years prior to )] TJ ET BT 26.250 379.464 Td /F1 9.8 Tf [(diagnosis. Figure 5 shows age at symptom onset vs. age at diagnosis for the Duchenne/Becker group.)] TJ ET 0.965 0.965 0.965 rg 26.250 190.429 555.000 179.155 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 369.583 m 581.250 369.583 l 581.250 368.833 l 26.250 368.833 l f 26.250 190.429 m 581.250 190.429 l 581.250 191.179 l 26.250 191.179 l f q 225.000 0 0 134.250 35.250 225.583 cm /I19 Do Q q 35.250 201.679 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 210.060 Td /F4 9.8 Tf [(Fig. 5: Reported ages of participants at diagnosis \(n=1562\) and onset of symptoms \(n=1233\).)] TJ ET Q BT 26.250 173.405 Td /F4 9.8 Tf [(Family History)] TJ ET BT 26.250 154.000 Td /F1 9.8 Tf [(Dystrophinopathies are X-linked genetic conditions, and in about 70% of cases the mother is expected to be a carrier and about )] TJ ET BT 26.250 142.095 Td /F1 9.8 Tf [(30% are expected to result from new mutations. Of 1,680 respondents, 416 report that other family members have a similar )] TJ ET BT 26.250 130.191 Td /F1 9.8 Tf [(muscle disease. Of 351 who provided additional detail, 38% identified a brother\(s\), 15% identified an uncle\(s\), 16% report a )] TJ ET BT 26.250 118.286 Td /F1 9.8 Tf [(cousin\(s\), and 12% identified a mother. \(Because of the lower prevalence of manifesting carriers and the fact that carriers are )] TJ ET BT 26.250 106.381 Td /F1 9.8 Tf [(permitted to enter their data in the registry, the majority of identified mothers are expected to represent known carriers vs. )] TJ ET BT 26.250 94.476 Td /F1 9.8 Tf [(manifesting females.\))] TJ ET BT 26.250 75.072 Td /F4 9.8 Tf [(Ambulation)] TJ ET BT 26.250 55.667 Td /F1 9.8 Tf [(To date, loss of ambulation is an inevitable milestone in the progression of DBMD, though the timing of loss of walking varies )] TJ ET BT 26.250 43.762 Td /F1 9.8 Tf [(considerably between and within Duchenne and Becker muscular dystrophies. Figure 6 shows the status of walking among the )] TJ ET Q q 15.000 29.476 577.500 747.524 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(pan-ethnic, participation rates among individuals of African American background are lower than expected, suggesting )] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(additional outreach and educational efforts are warranted to further engage this community.)] TJ ET BT 26.250 736.167 Td /F1 9.8 Tf [(DuchenneConnect is targeted toward participants in the US. However, the registry welcomes individuals from any country to )] TJ ET BT 26.250 724.262 Td /F1 9.8 Tf [(participate and has previously offered the survey in Spanish. \(This capability will return in the near future, and the survey will )] TJ ET BT 26.250 712.357 Td /F1 9.8 Tf [(also be offered in additional languages.\) To date, participants from 78 countries are represented in the registry \(see Figure 4\). )] TJ ET BT 26.250 700.452 Td /F1 9.8 Tf [(Languages spoken by participants include English, Spanish, German, French, Chinese, Italian, and Vietnamese.)] TJ ET 0.965 0.965 0.965 rg 26.250 463.512 555.000 227.059 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 690.571 m 581.250 690.571 l 581.250 689.821 l 26.250 689.821 l f 26.250 463.512 m 581.250 463.512 l 581.250 464.262 l 26.250 464.262 l f q 225.000 0 0 170.250 35.250 510.571 cm /I18 Do Q q 35.250 474.762 537.000 29.809 re W n 0.271 0.267 0.267 rg BT 35.250 495.048 Td /F4 9.8 Tf [(Fig. 4: DuchenneConnect continues to draw participants around the globe. The colored circles reflect areas with )] TJ ET BT 35.250 483.143 Td /F4 9.8 Tf [(more/fewer participants.)] TJ ET Q BT 26.250 446.488 Td /F4 9.8 Tf [(Age at Diagnosis)] TJ ET BT 26.250 427.083 Td /F1 9.8 Tf [(Frequently, families suspect that something is wrong regarding the health of their child before a diagnosis is established. Among )] TJ ET BT 26.250 415.179 Td /F1 9.8 Tf [(the total group of affected participants, the mean age of diagnosis was reported at 4.8 years. The mean age at diagnosis for )] TJ ET BT 26.250 403.274 Td /F1 9.8 Tf [(participants with Duchenne was 4.2 years, and for participants with Becker the mean age at diagnosis was 10.8 years. For )] TJ ET BT 26.250 391.369 Td /F1 9.8 Tf [(Duchenne the symptoms were first recognized on average 1.3 years prior to diagnosis, and for Becker 3.2 years prior to )] TJ ET BT 26.250 379.464 Td /F1 9.8 Tf [(diagnosis. Figure 5 shows age at symptom onset vs. age at diagnosis for the Duchenne/Becker group.)] TJ ET 0.965 0.965 0.965 rg 26.250 190.429 555.000 179.155 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 369.583 m 581.250 369.583 l 581.250 368.833 l 26.250 368.833 l f 26.250 190.429 m 581.250 190.429 l 581.250 191.179 l 26.250 191.179 l f q 225.000 0 0 134.250 35.250 225.583 cm /I19 Do Q q 35.250 201.679 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 210.060 Td /F4 9.8 Tf [(Fig. 5: Reported ages of participants at diagnosis \(n=1562\) and onset of symptoms \(n=1233\).)] TJ ET Q BT 26.250 173.405 Td /F4 9.8 Tf [(Family History)] TJ ET BT 26.250 154.000 Td /F1 9.8 Tf [(Dystrophinopathies are X-linked genetic conditions, and in about 70% of cases the mother is expected to be a carrier and about )] TJ ET BT 26.250 142.095 Td /F1 9.8 Tf [(30% are expected to result from new mutations. Of 1,680 respondents, 416 report that other family members have a similar )] TJ ET BT 26.250 130.191 Td /F1 9.8 Tf [(muscle disease. Of 351 who provided additional detail, 38% identified a brother\(s\), 15% identified an uncle\(s\), 16% report a )] TJ ET BT 26.250 118.286 Td /F1 9.8 Tf [(cousin\(s\), and 12% identified a mother. \(Because of the lower prevalence of manifesting carriers and the fact that carriers are )] TJ ET BT 26.250 106.381 Td /F1 9.8 Tf [(permitted to enter their data in the registry, the majority of identified mothers are expected to represent known carriers vs. )] TJ ET BT 26.250 94.476 Td /F1 9.8 Tf [(manifesting females.\))] TJ ET BT 26.250 75.072 Td /F4 9.8 Tf [(Ambulation)] TJ ET BT 26.250 55.667 Td /F1 9.8 Tf [(To date, loss of ambulation is an inevitable milestone in the progression of DBMD, though the timing of loss of walking varies )] TJ ET BT 26.250 43.762 Td /F1 9.8 Tf [(considerably between and within Duchenne and Becker muscular dystrophies. Figure 6 shows the status of walking among the )] TJ ET Q q 225.000 0 0 170.250 35.250 510.571 cm /I18 Do Q q 225.000 0 0 134.250 35.250 225.583 cm /I19 Do Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(4)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Muscular Dystrophy)] TJ ET Q endstream endobj 102 0 obj << /Type /Annot /Subtype /Link /A 103 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 510.5715 260.2500 680.8215 ] >> endobj 103 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig4.jpg) >> endobj 104 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 227 /ColorSpace /DeviceRGB /Filter /DCTDecode /BitsPerComponent 8 /Length 20033>> stream JFIF;CREATOR: gd-jpeg v1.0 (using IJG JPEG v62), quality = 90 C     C   ," }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?C}-N3޹$g$WW!1߷sZk6:RO,/1X/"$ل\}k*m D&N^-fT%`s`ۯ&O`WQ4Cs▟V_53%8"1\µ^Y>j7?tEԾ~N0=׵;$SX'Dy6?*)9<|\Ф׬H՞Cp} xu~4Z_Q&gw4i^ Dc7Ƴl56- R)RxϦ~'~ߧ5Pg׸WVF*+3P2?Lu3}jį'gQny n- M>.Q%.0_J֢𿈯BΑ ĩ1\.v,<[J}̹j;8Ox-ޤYt&!Th4y+׃qW_5]B[,BOF$ ? gⲄ8r0 ڕ݊} cۉ9RPJ<,kM:~.xcTٸ_ifIH%,˸9t<7i2'!0 * Iu秶{S5tC%xOX| ٓM'Xqч g8J*֗5R:Ov=_]a%{K-$KaϞANŞG:g CخUP"4A2=j]GY6~Դ]SKcө)|ӆm >Ap/6 #MtMI9ۮmu%tkú5>sa q|YY@ =;U7K$b8cz׏rUᲶv2,)$Xw֚\ 9$vϥyu.'Q[o ;vǜdw1"=rۮ+7Nx\5"E>]M&c I6'sWjwԖ41QG\ԵiSXmI)Qz#^J73+_pWiM&F(Qq[”3sKCZ޿3ܯر}+c֍oqL{u\q6EG~LYp?/GJ}&/&~R"gwUʚS;gF`3!ҡ觿Ҽ-h.;eVPs+5?ZXyZ2`n\{y5ϓɏq۞Vu奓,׋aNm88<_BR4ϰ>yƾm'/7?P'_nXV2H0'OjIC!18x{& Aq'UһZEm79$oɯj F3\4U@~oƸ_&m\x(n,X++sr d,:V7;74wu¼W@dJR2v⨪eNۙ׍XQ|7?yeyKjZiup8|.? ?ޫ5ĐCU-uPG巎.4\ %%lI'+ ,*\R+R57vޥ223IN.xN}jkn]j'OO}RTY m'U߳Ɠ*κx-&tlu*SkwKl.--S:kxբe p}+IQg3wR 'SNrЮlmTڠqwkkK' WBgWѢ.G$֔G$`Ѹ޹*!ZC)]OI ZncJզ-Y6 ֲ,%tّ7QO"'Zy2֛O%8 "|ıo?kfĶYa r@k4 b]"K^ ]Dq*qF8|{{j[t[%E\ӊܴ>iiL"@#NvZMQa&7N?*fEoSU\a '#o#aI|v7=Ȼ+®ϜJs If>յ rw1n?d_ NYDl 0y={f1ޫq7CUvqpwg}mrq=IOLG^ue.QΫmͱqcߎGxbN7mt^zrA]g&ۭ㭕3,[[WG6ѢEk#MC 1WMxkÚN4wlo{/OX:,K:67r?S_-xX(r]Rw#$xL,u?(&kwa{.A#"o3Ĭ &CD=ȯNwM\jT%y;Z"^TZt+d`1v?x߀s#FG;X#]m-/2V\vOkQU{FF5~'\5Dl!{#Q&D.:~5 ys@C=Aϥ{چYͰ;ZHq~([ B;O\++Z\dȏ9]$ܽ@aIω;n(o% r2Gz&EJZ6-pG5]n駵 85Ez9T^CnEl|wU;qߓ\R* I݅h$1@ޖ5C$fFEBIw9G&UһlcB<2۸'NN oideH[qԐsp)E)k] yE V/s\fQ┌ z|B@@~֑@m'gфwrb)CwΒsNëV]F`YR%@LOIU# X**quT%gJbK;GILB GX4n(F3?$mof]8ܞ)y)F-"!$$;XxƵ-& 5|F4xnH 8 wiI3Yq'z5 ĨT.|9Lvet7hhuV Mf.pѩ)t_ikfFV+Ga@ce\FfQ:y哓p=d65syZSE L*qL4r G%WEnPd1u!2,O<{S[G&&R78kֵh3 FƸ;mT]pF:qZ[fF }jڔgY{OV' GcU*y3"˰mP{JjQEfQEt^XZjvfU4s&|rMxrFE-"ї>Q;;ka\Zv$GǮp1jqH֭]6S,[9I$P[9a=S]6 IxR.JAvmHȯcP:}k%4mTV:>p0:v)=s?]ɩ$ɼ$h?|Wpk_l^J(ҍUsG'u|3:^z픍 "2rZ0)*r#:E]'|[#YnG',@'?k'r=W#w^>zIK}\Bah681q.ボJ<a5]):TcL {ԾxFumZ[BV=Q}灜oMN]K`vWB f? U0p<rvBr= y.7X{UA)&Ґ*+[\@m:75X|F94'4}oKM"M [Tg0#n;b8J|+#Ifx+F}6Cr,q9$ZK`)''F`"DZjV"X-QAt9OB5n+vrNئxG9}fsia $o*Aw*NY޳9Mv6S I7mٝphҔѲK )=LBAV/&r0J J29>7O9EԖ%GfX;~p* Gt2-E%8vg|zI;J}Zg&X0Hz!Ο 9]8u&<_@UCGG-rΏy>&jlϋ? ~+\BJuidž|aΓ ;Nϵ|Ys}aQH)ǩȪu=5~MrMQjIe8@>i4 0E+`|ז|ſ'0OkY88s^ظ,r#'Waq1i<)Wt$E>gā3>B_Fm&-_') OIi~#Ҵ8Ck9MFuQ'Myf,.[.oߩpuWO.u` F7"M{YA<ߛ/WzQYxȇsOQT-!%mu<|{e&5ioV pg<`c';+]FPIq+/Ūўw.ĺ[}y)H#VV[JWZ񕟅C5ܗ,Idg}0^?RPVڪYt8>şZ~bѺB 9ּ(i揳zI]H/7ľ ҧ6j|2*v5LʹqXBf]c󯇾0hvM$fTl#1}?y"dtDF\?kӫ)6~qYFH֦nׯs* rCۭ}+e#A*Z'Py7)te ʒ1Y(A7)L>Wa״ͪ%o3􌧊1y- y'<+7ڣZFkJH`wS kҺ< YKbRTX5ΌܷKC d[qFz$zDž8vCDQ9gr~-:X [$<`^3X ΰ!gH%/ `GM~Y$bGJig=c0\^Jz#Zرy`#dxwU/K\xs}k68$xydO5KJGӵ9!cg#_eܸ2W454ǖ;uS89zuc]NL+8 'k"V ^OΫO!3$=kuW[[T4 0c x{gV!;U^- (:% g${ԕ#dkYo)]ս})ǚڽ ԅޠb%cla˲1uh"f-k9#޼J^{21,0 >z532]rOVv #ΣOu?y+_eGZq49ІW>#j,[3!U "yÑyu |/ M%޸M+6 sq%ݬ766wm=ҾC7ʪ5"˕ǫS,>OJḁm=6?)&wp3Ȟgd^־ձF@gJ𝾕apd=t}9`.gEC(Nl{WK)^7 I:*M:y_v44HlFmq<ʾ"Y6]\ZgS`(v2w`zWխ\@9b'C۷z_hv.g6vh|W-%fzy7, :\͢m>h"X6002I}cJT8TPbf}?Ö~s:W*K2x+bZyEiT `(bs9ml<}O<D⬻yv/x85KycvCom d+q>uhtɊoi<iЊfcR9+9J\-8C<Y a[}Q^x25Q-) 8 28ϹO[HT Q$Za?ҮWӧAZbօI[Sgk1Jw:U89L[皯t8?Sz,,fU-1NFτ4ׯ-5~C[jy JpNO ]|c@ &YFHea[KqyNv+g%ERĂGk1ζ4U BI<@4[QWg*Wv@OQ՗9ƭgiWZgO2Y6ڽ&GapBnUՕVUN9lWѡx6I{}/>O:u]iꡆ]eQe-ţnzj/ 7S ]yJ¬KCޝi ]#>U?jL Vk:L'OlfyRGp:zWk6:W673(!}Ӓ=Ey=w:wqy4\oGH€0-"< _,\KK+>-an}Km7'ӱk1XHW5xSn[KJA]Kᖝp+n*ҥU;y )zvA88}’iq%ƵZQ'cH* ['Ue/>Yhv#sj:.GM!n`@g#:qv[Υ$޷geN'݌[tӣZrء*[s_ |#joq*KyV$ cfm.>ר}^o*E,O9܏zGO0nt'ZD} 4CS΋oVvQl,[A;Dv<_u]C5(\gLUC+Sk!RsG#D: wF,׈i^'Q[b'Z 2dTX~mE8ͦRWLJPQG k#ΥlVʏl?YڈE6AkIev'9dBh?A5=SW%GYeN+kB\fhܸ=*.\ ]6đx&kS bF$!oq9dP( kfS&uMe\CpT躎 : UH_*Wv '5FrO\ 3EU$c'2㓒͎ g"M)IMݟg2 vHԵ#k{m*"ĀK ކ/xB5"icrF7(<{zUNRhI-93:mի}qm)\7#![ ;wZjV[V=^ F8g;RA5l iN\Ccuµv|z7D rZ[p<13t7 |Aqcq4Q ;8qԚ4N{H%:imQݔ G l_VժT6G 9e{kOM=m~{8--Z)H&#v3vxv(b,|/ Þ𬶗ѭmYK{$W;2 5 _4Ɋ/m+hCRўi{<_@5|PRW5t?&^7,t+{Mbf0a! MSQ$۵ԗ䢳| PIUui1=OFDdԗC̼AEծDR ebJہzZӚf$wv㹯TԸl ýH>|^-\ ZNH'.\QЦS6k}<鑄^LgYnIU cO?^ggr4Ki"b#K&&7vrFICWBi>Uv:]WA׬-KJ`mhۗ9>z_sឯBdx| ͍q[dA*9k+m՟ 'C|9g~-ipm0$؏@"zz0u"̵17ʸ*GPF)]&##2k\ H%>XWiՒՙ+4bR@ ׾h$,ZD1+*YmaGKx@2n¨ eheIukko{e<1As3[LLrR<~ҍҩZ<]a h̠ cp/x.3l4vpՈ}k5= ."!l,PV=%I͌o&QEjfQEQE(]G~Fn86kM8zӬ|-eХY$[]ӴoqϭJj]i̾T#%A}^.۝4fUqs~lmfx:fgjٻ]$"g0FN1s׉Y5?> ݬI(Af3A[]kiGaCb 2vЁ^IܿjXBekU ]%fk7K,c!X ÚiVR.T\wӚ bLr˨Ȩ3' sR( (y6D2IN0=ȫM:(V^I"KX11/pEyY~\ërGwkOX:ƷBD nAŒi!.N:*oaky-ٵA5ɖO\u m]ygib t_fGٽaht'Ҋt[D;S?1>ʼF767vW0$nVӎpI;v1u Y4=V+Weі `3DZu5?-7Âu@.U<|_WGTKxR DpYpg;8?kڻQή|̜Lr#nV*áWOFc+,-#cӽrbPm*o i*$z$iN\LUCro5Mh KYm }=y9=1z.ZJ.ְ3?t$g𯫵Դ53EnbBY]$8xOkkIp&qrCE&y?OpkgRsƴgkR1 LM~ز*@FqrO${U[E|L,+i?-ȑ18WOˢlܸ}?}N>Bڻ\>8m/N_Rj~9/w1@zhl9BރG^,Ubp,S=yrd D+G2ҳK~<{F3Eu$-p(oƥ?.ڬ)7cq'0m*2+Ʂlt綂X5_UX@P95}iWIy7 rYXA^s/ Kkel#Ģ9]ܠqZua&xu/g G"ua&x9߻ȊpNHW,])88uT1k~LjW-); >_ǚޔ&i91O'$P$GJv,TSULg'`q1H;o`ӜSy.%;lfqr3֑DFLM7?:uO΍O΋E76#,µ?swe9X(|scV\,t-2m{dBAV2kOK;+ jQݭD';[=j2KMeBGm ԝ,<=;PaGS)u+#-GJ83SV#-5lgWuFY 2-tFxeA]Nhoò:*N# DOs;2Ny^d|KU f|g 㫛5Y6q+ȉBO9z6p0h1k+Y1ω,6Gy:e|Qev.'FReBF990t-K/dQ;@a XFqTֿ 2`ܡ|lG?rENFa5xYbS%6CJ8* 6iWqɒ1 I}yG0r}kZǶVr-"4C N N)u /gq[ĸ)@,w8?NVl)@LEW;0yb-[S~mx@G:h,wGRJ5+?\h a:.EdOn1kO/5(ynL|$¬``՘<_38Fk Ytjc rW뷌 e$q4+88!Op:#kŌ d +G:bN:ld?QEy gZϴ?:}SεhGuC| (:}ֿ(_gZϴ_.?Qk>(ϵhGuE| (:}ֿ(>}'}E| (:}ֿ(_gϴ?QE`ֿ(εhE]gϴ?Qk>߱E]gϴ?E| (>}'}C| (:}ֿ(_`hE](ϵhE]*dQ@G@@ endstream endobj 105 0 obj << /Type /Annot /Subtype /Link /A 106 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 225.5835 260.2500 359.8335 ] >> endobj 106 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig5.jpg) >> endobj 107 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 179 /ColorSpace /DeviceRGB /Filter /DCTDecode /BitsPerComponent 8 /Length 12510>> stream JFIF;CREATOR: gd-jpeg v1.0 (using IJG JPEG v62), quality = 90 C     C   ," }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?RPv'RREP@Z)('#>u|-njOW֓xk/ZծJXR3}+cm~t"Ou.'£0.9}E|+/[g4 i2>;yewb]l( $hc_Mmi> յelw-Y&\|T,#b=֑m~t߃>#*šPG| SJX}H0r+nSĚ_ӡZm'[tk=FsZ2N:r@1h USP}yϏڎ:|P4k~0FTn4?ji¬:40A?+>xFïI iZ׆R rƹ :KuKc$}E|=Scb/`I5K{CBB$psOSVܠ sQ:'=?Fg&Ewmsq$;8^U-Gr@()h ( J)h;R)h3E.(@ Kފ(V+{)䴸Y-@ J@zD4%HFQr,q8)?[j%dѮm#ѯ Cu!Tb>+4Y6k &h?%?W|s ?0\]9\Wi9}iSipݙԜi[C5׍X #xIج79}3υt) {IoۙHThd˿`?hן R@M.[Ӥy⸶%0qB qW$g}?$?PhxcIU׋4}VOy.GtnrMz]#º7cou E*~ $5IأM3x'}x8隋Zį=о]Ý@sU(2´m>ba*܆Sof9'vi(L?@OᗄtOz='}7V5Jݔϕpz){V/?a>'5X%mtK[=feQ`A׹Kأ]3`|_(|Tno0뗖3kޗ Qc6b*zsA}\iZ-sWQw"Сf5FZItKؠ m~9>4j7dZz}x4[9#sW.ej>8NjG{j[.MLb.SL?G$g}ˏ姆'et- ћY ٷf~[s^拴` JL?G$g}Ӥ#%,pɭPKE!1F(KI@(g)h)sY+חvFi-х+I m 2}k9V▝\~b<082M D+. F^kuF{$P}r4~^\ 8ko 4,ˮ7/JYYp(Ҿx_F\^v$6Ql;2L3dtWx^[|zԼYu\hkӵxt]BhP6 'iפR5I3&Oƀ7ξp'EzHu?mN )w,^]OVqoT?e[ȏ>>Y/[9dhяsw$V^ /G$V^ /Hf>~gEeq4Eeq4tm?gCeq4Eeq4ѷu  <,Mh4cu  sFsw$6^ /G$V_4tm?gEeq4z,Mh4*/m+Z@Pt4Q))h4 KI@-%|x> NG?e}H2mnU$\c;ZH]>KDYN ɋ!9v q_uK=3GZZLWPp$cN<ׁ~-}SJ]#V;+h_]6Ҫv(;;޿M{w3EFzdt'k Fpk/[ielҶq{rݣ2D[Br @ i75W),[.w~~O&6hBe:ZJ'źU&\'v>zudjJq1Fq[G>w \N2%fjmm }A_+46J> |H#; =? |Hc+ =ҍҳ? |H#; =? |H#+ M |H#+ =? |H#; MҊ͏]I]PZ^lڀ €A& k࣠!yHٰ3xgtm22\K䗌U sOK[N(kFaV^۞ٚ+| k0ik#B{` ĪFRpK\ޏKJ4KPW$ic-dќ6=ڎ~8~k;Y4>4eVyƳ"M8*S*qn~:>}حƣ{ir0)ݍ {;Gsf@#~mi< \dIP>1#os1HY^Xz'KCj4  UHL_?y-g3Ht˴>|ր O73XKr0D cl-ѣګ$lGBlMNh:LSu,H$Q fM]Wj$RCx @O/cq<.px(k^!e/Q62%ŌlApハ־% DA^i0VV^.rOBRwYqWc1JuMX~W|>hKrfa%L1@|LAJ00Ψ^imd/' q}E|(kt4uTGLr[*8u W89*A~+TڤhuB4{fXbVi^YBTd?QWWa\G)EeUd_QWWa@V_uOC_mIYn}Ud?PGY_mnKYnnHk/"—گ!€4EgGyPtHహmhh ^O:uAhkѠE6K=ShLO7?ڇo,tx7[;obS2mRܹ?(c7gyi$+tKhZ:BDilk9;UHqmyy;uI]TC0~` ix t-g=Rqq M L!UR®F VͶ/A-tشшGZthY .WWZ}i-)qo*xP 7cW7ſ}2C[yAr2!K df%9J3RPKIAҀPPe OCniƫeuV߰U|[s묂kBf qdoO Լ760_$,ҨubXn9V#A᝷Ÿ Ǡ_XBٷ[mWU(I'&;:LJZ_ vb֫<2xz WK-'A– ՁY>%`?rWO[>[ReFPO'֫^.ϳC P)B>FV|`{bn7E3ri՘ꊿgOU?gMZotyگSHk?տjgMB[},)v>n4h;VK? 7Gϝ? +;տjgoF+?տjgOBj=~f[$3WրPoWc-͒e$BO/_^uoCE=V'}/g:4h]TGQzҽ-H>4u3W:sB12(W!=&S"k=F*? 2(^O-+o @<jj p+knw t`Yf/;w) zp@2h jڞs(:%Q4iv'xv( ~4Z/tyn6x0X!ko2roχ46Y$B$XJ"Ovv=~ WM^[\ȬG <#g'tj@`Jk x~ZO ׺7R1_ß?Q j7xŻu)MFEB 8~xE59modkmc>N]xݚ/]X6)F^@&@᳀yKL>?[~i\_[[е 9;Fbyn}ދK}RľYAq$Lī)RҾ'8ӭK/%xkYoԇMo[~mSi { VrP`#b7416 gҶ6cH8'$89Yl:IΧ{<"nfBJTk~oxM&NxO վC:H# 2 W|1x⍕~OTW ;HQB@TssR?;ӫgvgǒx.$2xUeDHCL;r~vQs\\jQ>#3=3 ZiZXԵMBx"Rᡋ1 OVχ:<~֫%Cle#:PFigi5E %cD$m$hVYX*~>|oK^ &+FDLx2'+T_<}m}}LdբFӣwuhb?0B=xCI4F/HN wGnӜ`l4?0šٶ55u} \m 98 |_ ߎm2[)4eI*vMnvƓL>.e\y2T3N+?D־ԵLs56Z۫LRI+.G\~\jo{%r}oj?ُSĢx"̦ۘ7L7'x[36^5?FѾ!j^+JTpR9HiDeee${-QEQE  ()h((QEQGZ;IKEQE4?ZM~sO<zw,xK]J[շXڷ$E?.JEt^6+W\tXm&ۼ봮e!=.ڵD\]B?"YpQG5>xX.6])$Fha™!]C 6d}uZ|?F}b湞x<̑if9m Gt^_UiB?*`Ӛ?v numKQ𶐖rZKor>HaX?? Msuwc|)Zo,JJq _| sZ?j4vP#MxUb%plB"8b{+e'W,N$)OojF[[_iմ3ZFc#=_)y!~!xŗONJ'K\.-p|㍤|oJ:嶧;Pd>"@X xZնom[Ek;W+ 8d;& lXsӜ? ^JIÒW )=Cp^U0Nk˴O7Kq=// m*H#>\F@^—֟m:5X DQYd"T@<ý7]sD}G 3kqǪZKiafVۃ AWGEpjzWq"~v> endobj 109 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig4.jpg) >> endobj 110 0 obj << /Type /Annot /Subtype /Link /A 111 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 225.5835 260.2500 359.8335 ] >> endobj 111 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig5.jpg) >> endobj 112 0 obj << /Type /Annot /Subtype /Link /A 113 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 510.5715 260.2500 680.8215 ] >> endobj 113 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig4.jpg) >> endobj 114 0 obj << /Type /Annot /Subtype /Link /A 115 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 225.5835 260.2500 359.8335 ] >> endobj 115 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig5.jpg) >> endobj 116 0 obj << /Type /Page /Parent 3 0 R /Annots [ 118 0 R 121 0 R 124 0 R 126 0 R 129 0 R 131 0 R 133 0 R 135 0 R 137 0 R 139 0 R 141 0 R 143 0 R ] /Contents 117 0 R >> endobj 117 0 obj << /Length 21587 >> stream 0.271 0.267 0.267 rg q 15.000 -107.309 577.500 884.309 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(patient participants. Of 1,575 participants who responded to this question, 1,060 \(67%\) are ambulatory and 508 \(33%\) are non-)] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(ambulatory. Of the non-ambulatory group, 1.4% have Becker, 30% have Duchenne, and 1.0% have an intermediary phenotype.)] TJ ET 0.965 0.965 0.965 rg 26.250 565.786 555.000 179.905 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 745.690 m 581.250 745.690 l 581.250 744.940 l 26.250 744.940 l f 26.250 565.786 m 581.250 565.786 l 581.250 566.536 l 26.250 566.536 l f q 225.000 0 0 135.000 35.250 600.940 cm /I20 Do Q q 35.250 577.036 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 585.417 Td /F4 9.8 Tf [(Fig. 6: Ambulation among patient participants in the Registry.)] TJ ET Q BT 26.250 548.762 Td /F1 9.8 Tf [(The mean age of full-time wheelchair use for those with Duchenne is 10.5 years, and for those with Becker is 21.5 years \(see )] TJ ET BT 26.250 536.857 Td /F1 9.8 Tf [(Figure 7\).)] TJ ET 0.965 0.965 0.965 rg 26.250 351.571 555.000 175.405 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 526.976 m 581.250 526.976 l 581.250 526.226 l 26.250 526.226 l f 26.250 351.571 m 581.250 351.571 l 581.250 352.321 l 26.250 352.321 l f q 225.000 0 0 130.500 35.250 386.726 cm /I21 Do Q q 35.250 362.821 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 371.202 Td /F4 9.8 Tf [(Fig. 7: Reported age of full-time wheelchair use.)] TJ ET Q BT 26.250 334.548 Td /F4 9.8 Tf [(Corticosteroid Use)] TJ ET BT 26.250 322.643 Td /F1 9.8 Tf [(Use of corticosteroids remains of strong interest to the community, especially following the adoption of the 2010 care )] TJ ET BT 26.250 310.738 Td /F1 9.8 Tf [(recommendations for Duchenne muscular dystrophy that confirm previously published basic guidelines as to their use \()] TJ ET 0.267 0.267 0.267 rg BT 538.866 310.738 Td /F1 9.8 Tf [([1])] TJ ET 0.271 0.267 0.267 rg BT 549.708 310.738 Td /F1 9.8 Tf [(\). Of )] TJ ET BT 26.250 298.833 Td /F1 9.8 Tf [(DuchenneConnect participants, 22% currently use prednisone and 29% currently use deflazacort. Thirty-six percent of )] TJ ET BT 26.250 286.929 Td /F1 9.8 Tf [(respondents have never used corticosteroids. Ten percent of respondents have used corticosteroids in the past but no longer )] TJ ET BT 26.250 275.024 Td /F1 9.8 Tf [(use them. Two percent were unsure about their corticosteroid use.)] TJ ET BT 26.250 255.619 Td /F1 9.8 Tf [(Among 1,564 patient participants:)] TJ ET 0.271 0.267 0.267 RG 40.337 239.182 m 40.337 239.629 40.154 240.073 39.838 240.389 c 39.522 240.704 39.078 240.888 38.631 240.888 c 38.185 240.888 37.741 240.704 37.425 240.389 c 37.109 240.073 36.925 239.629 36.925 239.182 c 36.925 238.735 37.109 238.291 37.425 237.975 c 37.741 237.660 38.185 237.476 38.631 237.476 c 39.078 237.476 39.522 237.660 39.838 237.975 c 40.154 238.291 40.337 238.735 40.337 239.182 c f BT 45.750 236.214 Td /F1 9.8 Tf [(28% \(444\) have Duchenne and use deflazacort)] TJ ET 40.337 223.527 m 40.337 223.974 40.154 224.418 39.838 224.734 c 39.522 225.050 39.078 225.233 38.631 225.233 c 38.185 225.233 37.741 225.050 37.425 224.734 c 37.109 224.418 36.925 223.974 36.925 223.527 c 36.925 223.081 37.109 222.637 37.425 222.321 c 37.741 222.005 38.185 221.821 38.631 221.821 c 39.078 221.821 39.522 222.005 39.838 222.321 c 40.154 222.637 40.337 223.081 40.337 223.527 c f BT 45.750 220.560 Td /F1 9.8 Tf [(21% \(322\) have Duchenne and use prednisone)] TJ ET 40.337 207.872 m 40.337 208.319 40.154 208.763 39.838 209.079 c 39.522 209.395 39.078 209.579 38.631 209.579 c 38.185 209.579 37.741 209.395 37.425 209.079 c 37.109 208.763 36.925 208.319 36.925 207.872 c 36.925 207.426 37.109 206.982 37.425 206.666 c 37.741 206.350 38.185 206.166 38.631 206.166 c 39.078 206.166 39.522 206.350 39.838 206.666 c 40.154 206.982 40.337 207.426 40.337 207.872 c f BT 45.750 204.905 Td /F1 9.8 Tf [(1% \(12\) have Becker and use either deflazacort or prednisone)] TJ ET 40.337 192.218 m 40.337 192.664 40.154 193.108 39.838 193.424 c 39.522 193.740 39.078 193.924 38.631 193.924 c 38.185 193.924 37.741 193.740 37.425 193.424 c 37.109 193.108 36.925 192.664 36.925 192.218 c 36.925 191.771 37.109 191.327 37.425 191.011 c 37.741 190.695 38.185 190.511 38.631 190.511 c 39.078 190.511 39.522 190.695 39.838 191.011 c 40.154 191.327 40.337 191.771 40.337 192.218 c f BT 45.750 189.250 Td /F1 9.8 Tf [(1% \(23\) have an intermediate presentation and use either deflazacort or prednisone)] TJ ET BT 26.250 166.095 Td /F1 9.8 Tf [(Of 1,564 participants who provided data about their ambulatory status and their corticosteroid use:)] TJ ET 40.337 149.658 m 40.337 150.105 40.154 150.549 39.838 150.865 c 39.522 151.181 39.078 151.364 38.631 151.364 c 38.185 151.364 37.741 151.181 37.425 150.865 c 37.109 150.549 36.925 150.105 36.925 149.658 c 36.925 149.212 37.109 148.768 37.425 148.452 c 37.741 148.136 38.185 147.952 38.631 147.952 c 39.078 147.952 39.522 148.136 39.838 148.452 c 40.154 148.768 40.337 149.212 40.337 149.658 c f BT 45.750 146.691 Td /F1 9.8 Tf [(40% \(624\) are ambulatory and use steroids)] TJ ET 40.337 134.003 m 40.337 134.450 40.154 134.894 39.838 135.210 c 39.522 135.526 39.078 135.710 38.631 135.710 c 38.185 135.710 37.741 135.526 37.425 135.210 c 37.109 134.894 36.925 134.450 36.925 134.003 c 36.925 133.557 37.109 133.113 37.425 132.797 c 37.741 132.481 38.185 132.297 38.631 132.297 c 39.078 132.297 39.522 132.481 39.838 132.797 c 40.154 133.113 40.337 133.557 40.337 134.003 c f BT 45.750 131.036 Td /F1 9.8 Tf [(26% \(411\) are ambulatory but not using steroids)] TJ ET 40.337 118.349 m 40.337 118.795 40.154 119.239 39.838 119.555 c 39.522 119.871 39.078 120.055 38.631 120.055 c 38.185 120.055 37.741 119.871 37.425 119.555 c 37.109 119.239 36.925 118.795 36.925 118.349 c 36.925 117.902 37.109 117.458 37.425 117.142 c 37.741 116.826 38.185 116.642 38.631 116.642 c 39.078 116.642 39.522 116.826 39.838 117.142 c 40.154 117.458 40.337 117.902 40.337 118.349 c f BT 45.750 115.381 Td /F1 9.8 Tf [(11% \(176\) are not ambulatory and using steroids)] TJ ET 40.337 102.694 m 40.337 103.141 40.154 103.585 39.838 103.901 c 39.522 104.216 39.078 104.400 38.631 104.400 c 38.185 104.400 37.741 104.216 37.425 103.901 c 37.109 103.585 36.925 103.141 36.925 102.694 c 36.925 102.247 37.109 101.803 37.425 101.487 c 37.741 101.172 38.185 100.988 38.631 100.988 c 39.078 100.988 39.522 101.172 39.838 101.487 c 40.154 101.803 40.337 102.247 40.337 102.694 c f BT 45.750 99.726 Td /F1 9.8 Tf [(20% \(319\) are not ambulatory and not using steroids)] TJ ET BT 26.250 76.572 Td /F1 9.8 Tf [(Figures 8 and 9 represent corticosteroid use among ambulatory and non-ambulatory patients.)] TJ ET 0.965 0.965 0.965 rg 26.250 -107.309 555.000 174.000 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 66.691 m 581.250 66.691 l 581.250 65.941 l 26.250 65.941 l f q 225.000 0 0 158.250 35.250 -101.309 cm /I22 Do Q q 35.250 -107.309 537.000 0.000 re W n Q Q q 15.000 -107.309 577.500 884.309 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(patient participants. Of 1,575 participants who responded to this question, 1,060 \(67%\) are ambulatory and 508 \(33%\) are non-)] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(ambulatory. Of the non-ambulatory group, 1.4% have Becker, 30% have Duchenne, and 1.0% have an intermediary phenotype.)] TJ ET 0.965 0.965 0.965 rg 26.250 565.786 555.000 179.905 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 745.690 m 581.250 745.690 l 581.250 744.940 l 26.250 744.940 l f 26.250 565.786 m 581.250 565.786 l 581.250 566.536 l 26.250 566.536 l f q 225.000 0 0 135.000 35.250 600.940 cm /I20 Do Q q 35.250 577.036 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 585.417 Td /F4 9.8 Tf [(Fig. 6: Ambulation among patient participants in the Registry.)] TJ ET Q BT 26.250 548.762 Td /F1 9.8 Tf [(The mean age of full-time wheelchair use for those with Duchenne is 10.5 years, and for those with Becker is 21.5 years \(see )] TJ ET BT 26.250 536.857 Td /F1 9.8 Tf [(Figure 7\).)] TJ ET 0.965 0.965 0.965 rg 26.250 351.571 555.000 175.405 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 526.976 m 581.250 526.976 l 581.250 526.226 l 26.250 526.226 l f 26.250 351.571 m 581.250 351.571 l 581.250 352.321 l 26.250 352.321 l f q 225.000 0 0 130.500 35.250 386.726 cm /I21 Do Q q 35.250 362.821 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 371.202 Td /F4 9.8 Tf [(Fig. 7: Reported age of full-time wheelchair use.)] TJ ET Q BT 26.250 334.548 Td /F4 9.8 Tf [(Corticosteroid Use)] TJ ET BT 26.250 322.643 Td /F1 9.8 Tf [(Use of corticosteroids remains of strong interest to the community, especially following the adoption of the 2010 care )] TJ ET BT 26.250 310.738 Td /F1 9.8 Tf [(recommendations for Duchenne muscular dystrophy that confirm previously published basic guidelines as to their use \()] TJ ET 0.267 0.267 0.267 rg BT 538.866 310.738 Td /F1 9.8 Tf [([1])] TJ ET 0.271 0.267 0.267 rg BT 549.708 310.738 Td /F1 9.8 Tf [(\). Of )] TJ ET BT 26.250 298.833 Td /F1 9.8 Tf [(DuchenneConnect participants, 22% currently use prednisone and 29% currently use deflazacort. Thirty-six percent of )] TJ ET BT 26.250 286.929 Td /F1 9.8 Tf [(respondents have never used corticosteroids. Ten percent of respondents have used corticosteroids in the past but no longer )] TJ ET BT 26.250 275.024 Td /F1 9.8 Tf [(use them. Two percent were unsure about their corticosteroid use.)] TJ ET BT 26.250 255.619 Td /F1 9.8 Tf [(Among 1,564 patient participants:)] TJ ET 0.271 0.267 0.267 RG 40.337 239.182 m 40.337 239.629 40.154 240.073 39.838 240.389 c 39.522 240.704 39.078 240.888 38.631 240.888 c 38.185 240.888 37.741 240.704 37.425 240.389 c 37.109 240.073 36.925 239.629 36.925 239.182 c 36.925 238.735 37.109 238.291 37.425 237.975 c 37.741 237.660 38.185 237.476 38.631 237.476 c 39.078 237.476 39.522 237.660 39.838 237.975 c 40.154 238.291 40.337 238.735 40.337 239.182 c f BT 45.750 236.214 Td /F1 9.8 Tf [(28% \(444\) have Duchenne and use deflazacort)] TJ ET 40.337 223.527 m 40.337 223.974 40.154 224.418 39.838 224.734 c 39.522 225.050 39.078 225.233 38.631 225.233 c 38.185 225.233 37.741 225.050 37.425 224.734 c 37.109 224.418 36.925 223.974 36.925 223.527 c 36.925 223.081 37.109 222.637 37.425 222.321 c 37.741 222.005 38.185 221.821 38.631 221.821 c 39.078 221.821 39.522 222.005 39.838 222.321 c 40.154 222.637 40.337 223.081 40.337 223.527 c f BT 45.750 220.560 Td /F1 9.8 Tf [(21% \(322\) have Duchenne and use prednisone)] TJ ET 40.337 207.872 m 40.337 208.319 40.154 208.763 39.838 209.079 c 39.522 209.395 39.078 209.579 38.631 209.579 c 38.185 209.579 37.741 209.395 37.425 209.079 c 37.109 208.763 36.925 208.319 36.925 207.872 c 36.925 207.426 37.109 206.982 37.425 206.666 c 37.741 206.350 38.185 206.166 38.631 206.166 c 39.078 206.166 39.522 206.350 39.838 206.666 c 40.154 206.982 40.337 207.426 40.337 207.872 c f BT 45.750 204.905 Td /F1 9.8 Tf [(1% \(12\) have Becker and use either deflazacort or prednisone)] TJ ET 40.337 192.218 m 40.337 192.664 40.154 193.108 39.838 193.424 c 39.522 193.740 39.078 193.924 38.631 193.924 c 38.185 193.924 37.741 193.740 37.425 193.424 c 37.109 193.108 36.925 192.664 36.925 192.218 c 36.925 191.771 37.109 191.327 37.425 191.011 c 37.741 190.695 38.185 190.511 38.631 190.511 c 39.078 190.511 39.522 190.695 39.838 191.011 c 40.154 191.327 40.337 191.771 40.337 192.218 c f BT 45.750 189.250 Td /F1 9.8 Tf [(1% \(23\) have an intermediate presentation and use either deflazacort or prednisone)] TJ ET BT 26.250 166.095 Td /F1 9.8 Tf [(Of 1,564 participants who provided data about their ambulatory status and their corticosteroid use:)] TJ ET 40.337 149.658 m 40.337 150.105 40.154 150.549 39.838 150.865 c 39.522 151.181 39.078 151.364 38.631 151.364 c 38.185 151.364 37.741 151.181 37.425 150.865 c 37.109 150.549 36.925 150.105 36.925 149.658 c 36.925 149.212 37.109 148.768 37.425 148.452 c 37.741 148.136 38.185 147.952 38.631 147.952 c 39.078 147.952 39.522 148.136 39.838 148.452 c 40.154 148.768 40.337 149.212 40.337 149.658 c f BT 45.750 146.691 Td /F1 9.8 Tf [(40% \(624\) are ambulatory and use steroids)] TJ ET 40.337 134.003 m 40.337 134.450 40.154 134.894 39.838 135.210 c 39.522 135.526 39.078 135.710 38.631 135.710 c 38.185 135.710 37.741 135.526 37.425 135.210 c 37.109 134.894 36.925 134.450 36.925 134.003 c 36.925 133.557 37.109 133.113 37.425 132.797 c 37.741 132.481 38.185 132.297 38.631 132.297 c 39.078 132.297 39.522 132.481 39.838 132.797 c 40.154 133.113 40.337 133.557 40.337 134.003 c f BT 45.750 131.036 Td /F1 9.8 Tf [(26% \(411\) are ambulatory but not using steroids)] TJ ET 40.337 118.349 m 40.337 118.795 40.154 119.239 39.838 119.555 c 39.522 119.871 39.078 120.055 38.631 120.055 c 38.185 120.055 37.741 119.871 37.425 119.555 c 37.109 119.239 36.925 118.795 36.925 118.349 c 36.925 117.902 37.109 117.458 37.425 117.142 c 37.741 116.826 38.185 116.642 38.631 116.642 c 39.078 116.642 39.522 116.826 39.838 117.142 c 40.154 117.458 40.337 117.902 40.337 118.349 c f BT 45.750 115.381 Td /F1 9.8 Tf [(11% \(176\) are not ambulatory and using steroids)] TJ ET 40.337 102.694 m 40.337 103.141 40.154 103.585 39.838 103.901 c 39.522 104.216 39.078 104.400 38.631 104.400 c 38.185 104.400 37.741 104.216 37.425 103.901 c 37.109 103.585 36.925 103.141 36.925 102.694 c 36.925 102.247 37.109 101.803 37.425 101.487 c 37.741 101.172 38.185 100.988 38.631 100.988 c 39.078 100.988 39.522 101.172 39.838 101.487 c 40.154 101.803 40.337 102.247 40.337 102.694 c f BT 45.750 99.726 Td /F1 9.8 Tf [(20% \(319\) are not ambulatory and not using steroids)] TJ ET BT 26.250 76.572 Td /F1 9.8 Tf [(Figures 8 and 9 represent corticosteroid use among ambulatory and non-ambulatory patients.)] TJ ET 0.965 0.965 0.965 rg 26.250 -107.309 555.000 174.000 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 66.691 m 581.250 66.691 l 581.250 65.941 l 26.250 65.941 l f q 225.000 0 0 158.250 35.250 -101.309 cm /I22 Do Q q 35.250 -107.309 537.000 0.000 re W n Q Q q 15.000 -107.309 577.500 884.309 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(patient participants. Of 1,575 participants who responded to this question, 1,060 \(67%\) are ambulatory and 508 \(33%\) are non-)] TJ ET BT 26.250 755.571 Td /F1 9.8 Tf [(ambulatory. Of the non-ambulatory group, 1.4% have Becker, 30% have Duchenne, and 1.0% have an intermediary phenotype.)] TJ ET 0.965 0.965 0.965 rg 26.250 565.786 555.000 179.905 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 745.690 m 581.250 745.690 l 581.250 744.940 l 26.250 744.940 l f 26.250 565.786 m 581.250 565.786 l 581.250 566.536 l 26.250 566.536 l f q 225.000 0 0 135.000 35.250 600.940 cm /I20 Do Q q 35.250 577.036 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 585.417 Td /F4 9.8 Tf [(Fig. 6: Ambulation among patient participants in the Registry.)] TJ ET Q BT 26.250 548.762 Td /F1 9.8 Tf [(The mean age of full-time wheelchair use for those with Duchenne is 10.5 years, and for those with Becker is 21.5 years \(see )] TJ ET BT 26.250 536.857 Td /F1 9.8 Tf [(Figure 7\).)] TJ ET 0.965 0.965 0.965 rg 26.250 351.571 555.000 175.405 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 526.976 m 581.250 526.976 l 581.250 526.226 l 26.250 526.226 l f 26.250 351.571 m 581.250 351.571 l 581.250 352.321 l 26.250 352.321 l f q 225.000 0 0 130.500 35.250 386.726 cm /I21 Do Q q 35.250 362.821 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 371.202 Td /F4 9.8 Tf [(Fig. 7: Reported age of full-time wheelchair use.)] TJ ET Q BT 26.250 334.548 Td /F4 9.8 Tf [(Corticosteroid Use)] TJ ET BT 26.250 322.643 Td /F1 9.8 Tf [(Use of corticosteroids remains of strong interest to the community, especially following the adoption of the 2010 care )] TJ ET BT 26.250 310.738 Td /F1 9.8 Tf [(recommendations for Duchenne muscular dystrophy that confirm previously published basic guidelines as to their use \()] TJ ET 0.267 0.267 0.267 rg BT 538.866 310.738 Td /F1 9.8 Tf [([1])] TJ ET 0.271 0.267 0.267 rg BT 549.708 310.738 Td /F1 9.8 Tf [(\). Of )] TJ ET BT 26.250 298.833 Td /F1 9.8 Tf [(DuchenneConnect participants, 22% currently use prednisone and 29% currently use deflazacort. Thirty-six percent of )] TJ ET BT 26.250 286.929 Td /F1 9.8 Tf [(respondents have never used corticosteroids. Ten percent of respondents have used corticosteroids in the past but no longer )] TJ ET BT 26.250 275.024 Td /F1 9.8 Tf [(use them. Two percent were unsure about their corticosteroid use.)] TJ ET BT 26.250 255.619 Td /F1 9.8 Tf [(Among 1,564 patient participants:)] TJ ET 0.271 0.267 0.267 RG 40.337 239.182 m 40.337 239.629 40.154 240.073 39.838 240.389 c 39.522 240.704 39.078 240.888 38.631 240.888 c 38.185 240.888 37.741 240.704 37.425 240.389 c 37.109 240.073 36.925 239.629 36.925 239.182 c 36.925 238.735 37.109 238.291 37.425 237.975 c 37.741 237.660 38.185 237.476 38.631 237.476 c 39.078 237.476 39.522 237.660 39.838 237.975 c 40.154 238.291 40.337 238.735 40.337 239.182 c f BT 45.750 236.214 Td /F1 9.8 Tf [(28% \(444\) have Duchenne and use deflazacort)] TJ ET 40.337 223.527 m 40.337 223.974 40.154 224.418 39.838 224.734 c 39.522 225.050 39.078 225.233 38.631 225.233 c 38.185 225.233 37.741 225.050 37.425 224.734 c 37.109 224.418 36.925 223.974 36.925 223.527 c 36.925 223.081 37.109 222.637 37.425 222.321 c 37.741 222.005 38.185 221.821 38.631 221.821 c 39.078 221.821 39.522 222.005 39.838 222.321 c 40.154 222.637 40.337 223.081 40.337 223.527 c f BT 45.750 220.560 Td /F1 9.8 Tf [(21% \(322\) have Duchenne and use prednisone)] TJ ET 40.337 207.872 m 40.337 208.319 40.154 208.763 39.838 209.079 c 39.522 209.395 39.078 209.579 38.631 209.579 c 38.185 209.579 37.741 209.395 37.425 209.079 c 37.109 208.763 36.925 208.319 36.925 207.872 c 36.925 207.426 37.109 206.982 37.425 206.666 c 37.741 206.350 38.185 206.166 38.631 206.166 c 39.078 206.166 39.522 206.350 39.838 206.666 c 40.154 206.982 40.337 207.426 40.337 207.872 c f BT 45.750 204.905 Td /F1 9.8 Tf [(1% \(12\) have Becker and use either deflazacort or prednisone)] TJ ET 40.337 192.218 m 40.337 192.664 40.154 193.108 39.838 193.424 c 39.522 193.740 39.078 193.924 38.631 193.924 c 38.185 193.924 37.741 193.740 37.425 193.424 c 37.109 193.108 36.925 192.664 36.925 192.218 c 36.925 191.771 37.109 191.327 37.425 191.011 c 37.741 190.695 38.185 190.511 38.631 190.511 c 39.078 190.511 39.522 190.695 39.838 191.011 c 40.154 191.327 40.337 191.771 40.337 192.218 c f BT 45.750 189.250 Td /F1 9.8 Tf [(1% \(23\) have an intermediate presentation and use either deflazacort or prednisone)] TJ ET BT 26.250 166.095 Td /F1 9.8 Tf [(Of 1,564 participants who provided data about their ambulatory status and their corticosteroid use:)] TJ ET 40.337 149.658 m 40.337 150.105 40.154 150.549 39.838 150.865 c 39.522 151.181 39.078 151.364 38.631 151.364 c 38.185 151.364 37.741 151.181 37.425 150.865 c 37.109 150.549 36.925 150.105 36.925 149.658 c 36.925 149.212 37.109 148.768 37.425 148.452 c 37.741 148.136 38.185 147.952 38.631 147.952 c 39.078 147.952 39.522 148.136 39.838 148.452 c 40.154 148.768 40.337 149.212 40.337 149.658 c f BT 45.750 146.691 Td /F1 9.8 Tf [(40% \(624\) are ambulatory and use steroids)] TJ ET 40.337 134.003 m 40.337 134.450 40.154 134.894 39.838 135.210 c 39.522 135.526 39.078 135.710 38.631 135.710 c 38.185 135.710 37.741 135.526 37.425 135.210 c 37.109 134.894 36.925 134.450 36.925 134.003 c 36.925 133.557 37.109 133.113 37.425 132.797 c 37.741 132.481 38.185 132.297 38.631 132.297 c 39.078 132.297 39.522 132.481 39.838 132.797 c 40.154 133.113 40.337 133.557 40.337 134.003 c f BT 45.750 131.036 Td /F1 9.8 Tf [(26% \(411\) are ambulatory but not using steroids)] TJ ET 40.337 118.349 m 40.337 118.795 40.154 119.239 39.838 119.555 c 39.522 119.871 39.078 120.055 38.631 120.055 c 38.185 120.055 37.741 119.871 37.425 119.555 c 37.109 119.239 36.925 118.795 36.925 118.349 c 36.925 117.902 37.109 117.458 37.425 117.142 c 37.741 116.826 38.185 116.642 38.631 116.642 c 39.078 116.642 39.522 116.826 39.838 117.142 c 40.154 117.458 40.337 117.902 40.337 118.349 c f BT 45.750 115.381 Td /F1 9.8 Tf [(11% \(176\) are not ambulatory and using steroids)] TJ ET 40.337 102.694 m 40.337 103.141 40.154 103.585 39.838 103.901 c 39.522 104.216 39.078 104.400 38.631 104.400 c 38.185 104.400 37.741 104.216 37.425 103.901 c 37.109 103.585 36.925 103.141 36.925 102.694 c 36.925 102.247 37.109 101.803 37.425 101.487 c 37.741 101.172 38.185 100.988 38.631 100.988 c 39.078 100.988 39.522 101.172 39.838 101.487 c 40.154 101.803 40.337 102.247 40.337 102.694 c f BT 45.750 99.726 Td /F1 9.8 Tf [(20% \(319\) are not ambulatory and not using steroids)] TJ ET BT 26.250 76.572 Td /F1 9.8 Tf [(Figures 8 and 9 represent corticosteroid use among ambulatory and non-ambulatory patients.)] TJ ET 0.965 0.965 0.965 rg 26.250 -107.309 555.000 174.000 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 66.691 m 581.250 66.691 l 581.250 65.941 l 26.250 65.941 l f q 225.000 0 0 158.250 35.250 -101.309 cm /I22 Do Q q 35.250 -107.309 537.000 0.000 re W n Q Q q 225.000 0 0 135.000 35.250 600.940 cm /I20 Do Q q 225.000 0 0 130.500 35.250 386.726 cm /I21 Do Q q 225.000 0 0 158.250 35.250 -101.309 cm /I22 Do Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(5)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Muscular Dystrophy)] TJ ET Q endstream endobj 118 0 obj << /Type /Annot /Subtype /Link /A 119 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 600.9405 260.2500 735.9405 ] >> endobj 119 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig6.jpg) >> endobj 120 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 180 /ColorSpace /DeviceRGB /Filter /DCTDecode /BitsPerComponent 8 /Length 10268>> stream JFIF;CREATOR: gd-jpeg v1.0 (using IJG JPEG v62), quality = 90 C     C   ," }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?RQA (h%-bOjmS^/ڮcՌ2G]ʑZxԼ;N _hVD /m~ld>FXxY烿|:[k>VHeBwXf*Ks]oZu_A{H5WAN< 05?~I5Wuܚ'-U*@W4n$~Ҟ85A0= 'hQx7\m,5E1X,Cvks ᗏ<#w^^v;K} i d"k 'ʣ9>oW.F)o4MRK+&٤hy̿yJ?(Rݗ[OsxIjMJԖct1"Bo@h_ x%x%#աRkȚPۼ l{a' >mmd2+vdhv C>oW\Xk:Ni_K +~%eY'*AYCEy⏈~l|c}dKӮ< ے?h^%+ J;mJc$6@ m*qfGo]h6'lK6cX>vc y\u`(z+ŵ CVft믡qi< Y I?uI39iojh.t7:6k}ied_51CT9}/+]CƉ.k&z ]CMn[c(?C+_ >+g )D?C@袌PGj((Q@ъ(PEu4QG@J(95O[uMJ4yK瀣~~_;z{Xَ[?#E<_# W7ɿpਫ਼@Cdعa.3.w ෶b)(RN2@^EyN+|("5/if n&B'O]z[+k'|P %F(o?ej3O}GY+`g[y[kxOiy޵[똴tU6R)WFPnL0k1foΧjS[;0TnAg3~Wy]iwy-lFFH`2#vtPk`]F}K[=snTq w>={rIayulvb $,K)q^Eq> 7ZsB4H^F ],/2x VGgKE,O]^N5lѳ$B0C+i(־ x/^􋟶X)^!2##$   Wt0]\+JB؏]^8q,ZƜu8g&ʑV%#rUg5it>gaj+kXR ( @h43GJ((4Rb(Q@gx@ԠnŨo"[\ HTl h_N}( Uzfck.l1D5N`2 sT/~+Kѵt{fD2y*o; ,m]l S獾2^N}д-BU0Hۼ8rr ~jȼ4H'ȑĒI4c^G% AdT7^:}Ia Am)3)wExe&"!wd gJGI_7 92~p܍& bPWxؠIUy ㎼tݡxh}$$-w) 18e]y.\l~5|Aaj;Ky{s$WkevEum ܓBч#)Au 4I4N0 ܤzk5[o<< \7k4fPFiq^^_|%žxQC%xccRǽ#Hq_ݨӨUt^X IF緔H=CVwހE&F@ )7ZiК7 M).ށ] )7Z ށE&y) 'ʸ#jփԬ!No4X܋.i#3 1j|Aūq|bH,bH,IsZ?A^|%zwz]?#-s<3a.74Oh`ɂ3^35OLf7A,",N*.nϱCִJP6 ՝ h `Q)PU= y:e.ZKC?t`^ "0˕mυS>K+KXPG DE8z @(()nR=ihƚ4I,<1\ rN8ALI& 7FI-1Dq+)%ao??Sؾo5+[G$A#ka-pGg5ivV}x=ynmbm.m%Bq봽Igv:M xN G+6 2dGz<-^-msem5PB!z w=k!m`Γ!-xq C:H§` 9 We\Jk7PĚ|HF%*_v;mE'$wTl`C8.D%. hG&/LVOk// |p񞃮3kz=<6ѻ1G^,ur߁58BN4sNG~k jºsj:%i!8jeVUQk٭͗ msEpfNq[Cԓݝ}^]L* +2onƱ( bSo.| J#4p8'uKozCu4*-mB{R?딿$%2rv}/2{=և3ue}r?E6Y\$W?'`ObRsRi}E;F>Stzc/}a./4譧0d+~0X]__[H$GS59-hRf|^?$aRk_M/wJ?{X+봯|E=$_˃^'$@%q.?7:vϊ{J6q#z:('&#c52Lq" 5Ρ>+ۋFBk%W8qF u_ irlC](woSX:\\W:u$ʘS]E7 'Uw9%NQα,^+&Kv ?_289?aBl@ug+;~gQN̏ (QGJ(((;PHt7>j,M$-q_ r{W핧=zD]i$ {,КU5y _;GG'WL>sGG3ßJ9J? @9J? 9AG~sG>€ J1() e.a_IP7[QKdq ? 饊Grky MWw:o_WtxJFooeum.4KXm6MI.(œ$-؝G_me.bvp?BmX ؑP`1_AO=K(ʮV4OM 'ྴqnHi}T At z%P%0å.+ѝYԷ3hS>QEdhQEQEgފSd|CQ^:,9«G|=佴Žٵˆauh+\F~g$ GƳz~Mh<+d]:BW\“w>qڕfL%Uw|Zox#$c g^KHf+oܛ;ȡs$1a~S'5yeчS V5;4~bk-uK7Ss[΅]v"++ׂ4fž/5d]x-I=dyd+1م|/xZA=V\Ӭ}FVT^,8Ϸwџ@xBD$yN dJsqUbl=k(|,`}H^~b n>,}7ךsU6j}ezV>S{sKW4w_X?eM5%OfҗW?utcUf^ǝNkR^kN;Şw%&FXGψ595fȺFwxT<+}}Nϟ١&Vos\@A{A[28h\jguޑI|nԮ6jx!2BWZ۵ ٮvGtuƜa<&^~`dwf֓Lw͸ &E#I s ~~?O? %>-l͕sqtZ=lU: yo/X>\n&SЎppǜ  ZEh=+#VyQV`Qڊ((@(^f-u;y>> E2L#ĭF˓Uǟڬvw"FYB wlqno$ddheYef@q,q[H7WZV][a$r%$pƤuu=J{h I4q#Xbp \cUK㷆4{.b{m#)JYQ $A_?e};`+yw u =kՂA\<_LLgkx$m+Csk =q:?࿉p^&𶗬]kU3(fLo_(4 &By/\C; FUG> c]GfiF_ئHN=8q_0cYi[Xp/ o̼]ONҮ32PFEfsW'z51[,wooF[KLw%Jx6{*rV)FzUf}k ˦sx[}՝b/:ujKK[#I#Sz`浕Q$RC}/,/t^JQ%WYi(=EfJNrtU)y$>$@yA$&a?tmcŚ-+p5^})xe~ Z;Kin8H-2;e_||#xQܓ}!O |:|=3D+ai95pn:g#T0eP=B\ _d|Y?-y[v`ր|`dN5iEm\uj'dbW74{}'Al}6+/ֶ@ju (Q@Q;ъ(1EQGQEj> endobj 122 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig7.jpg) >> endobj 123 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 174 /ColorSpace /DeviceRGB /Filter /DCTDecode /BitsPerComponent 8 /Length 13130>> stream JFIF;CREATOR: gd-jpeg v1.0 (using IJG JPEG v62), quality = 90 C     C   ," }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?R((š,p>;W_l:C͎q?[y/'fuZ8 2Xj6% =䷊^81 P4'ems:'MOk _%d[*-Q]JSq^Gխ|%<+-ƱN5]6.4*#Hd\|m&hi;_'|3|JbY{A 8ȉRHH<=cjCswqjV{>m溾H >L?r8hh~&վ$V(մ/Mwn& H㰽Hmrp+IHu7I=sxXύ乏JԮll`H`s@M_+߶-,Mwƚ޽Xh:/5D_kӒ+mQ!`}oe0PsHZ?i|)' |zawcoxnpH(ʠAR6}OEx&=oǚimVRkv  JRqqZgMៀe ?Ul;>H'9ހ>@GegminO/$]ȭyZUbc\a8ԧ9oT<;ksY\Gcm t"B7*#`023{MWX?o5MSL.ӢҼ{0 a T / WCf=kqj6ݮm%Y"+-LLJOJj;WmehW> S0ϵq_a}vƷ=TїF6Z@Z[XEaDr#'_p@8.ZƩW7s Amu*cHУc5i!h^D#׼A]knyBn.$ BF¨'s׾Q@i5I?ۼ+ϲ[. hD` 20G5~1xR't5-KO/4[)[),eh}J84#ok&{Sk3;K:2+( =: உxZJcx2[t+Hχpˎ#n9@C(9 пd h>'!ԵI.mEc(_TǞɜ/zwd~^ Լ;hwe6"[a)!%WpGt( |1jW엒+ F59 暯%M~%vx %t\hvsɯ(Xūh'x&(0@?/NOa X>kz=HL/@3asY)#4χa:~[Yj_\ˤZIgIL>p/q*ȚG5*þ+]ZA4>N2@Ӄ!W#^E|sx6zn5=b]?G߅a,k$ B}b\cU[6w)W6"e[X*l$P8r:tP 6 GQ-5S$bCrycz1o5k xoNŢ X3*d-t(ၼ!&} ν\WZ:vi$W1Щ, ;-Hx|:&67ڍ$b+N^A<7m5ܗV ֶly(CE $jk 57?f'^:޴|=A|4c4n3 >2((kب앦x}̶Og/ج?^ P7|+Yk ?j-K/pYe^b^8nk4PEP:HN9u (4twڅ4mKR[9Mɶgp(`?l}mw$q@83! GDY18o. GMӢ3?7G#N@[ko}uEf=m=:o.GM֝?7ZtPg#z{_t]if=m=:o.GM֝?7ZtPg#>#uM֝ "FwFsMMj(hY!/HM˴82m=3Z5x·ebڄMΐ썎א0Kc<>ch7Zue6+q]!1Fgc  b>5]5;1dTLdNoN |ʟ¿+72^Ǡ魤K& Rݒaopjwdn_$$EaA|%y}ݍiOfKQHa=Vll`О6h|5v[d151 BzN[džuOA4tk_Cֶ&ek_C@[Zؤ P?kĩή2ŀ@zc|ECXs[PB+9{Ώ}\A5#;%z8hEҔJ'^Oڨ,Vwy?$fs"SJb2GAIvG`=խڅ_2KR1nϛEMzg`ΣIJF]áhspZ7Z_I}'4 lv<Y?߆4> ?=)Xx7vWZ[D%ۂd ٫@s?I==rȷsι#kTi6W?9&Io.9yҍkN;)Gw\}-gTi?\O j/axchIyh"I3Js5x jcɠ z1Izo6\>#h~=rO7FɵxC]dOe^S>zk>?&Tc:Sq֪R0]o"?Hλ_s襪WZ" g]?Z<s-Ze-Eg OjTc0-q~j}Kf OG*_~FOOa [o*Z#-ox/Nb+EwY _\?/a]DF) n;xǭ.3E7p=h 0)7QF@ F&F@ F)7Z7ZZ).@ )7Z7Z\{QIzѼzъM֓xI Rހ 2$M p1*2 t Yx1k M=0>ЅZ0:N1h'!n5='L[ī+Mcj"gpҾ~w?esu_aLG5ox \qj-՜xH;ƃ0>ď ?zӝ*c5ggZqjn?c}{[UkS"|,ng/5Β.0q[/{KTg6[_8--C~:̖Vp,5"%hnTuk[⮙iʚu6ןcHLÚ2 OҤ__hoy4Z 7hISo_vdž+hູkXngD$rŐ$vζN#9XspsZVWlfS ~+'bP[=FO/z?xQdw_EoELmϯZ[Ҿ0hzo<6,%hXk&#09Vi|@"Qk,ȱXecWr{IUmoMZm>­O %~0Z^Fu a3ߝ|."W ^[ C7y33ןZ_:v(/!Mymo O&[V :( Xm$Y@;o>wn#S.<ȍ'[o[~šVK|>>zXt;hܔ>6g8^+[x-aQc9? Uxgqx[Ӯ(UfBp<K'ޛJ{Dkem܅gq p$ddUg}}zVj-8!!?dXGu[? 2#}OJ7O⍆}mx,&?lqߥv>$i;. ZIrxǂs)8$V2׵};SL֦1FT:ݹn^"{6Цu xx%fF҃|tuW=OڟW_NI*bg:F|sֻƚ*VѬh4f5ruf\W5W|[myq7kiyq3FI$jђSvڠr@$g Ԡ\BjE;c[knnGqmiyn\:S^:j~fF6یǞz/B𥞿a ]oĥNWr*A5>ӼEs}`K][@J%I7,@pw.g+5nN6xQ/a%aKcmuSRx3~<>75 'Mn]e/%eL*ec#7*:Y(Ӯl"YG?qC#sGWkλk*}2]-+Я.{4,FT; 'Ocwi.5;8@~$%v@M'oё}:IQ!$F3c,ێdv*A=f^W#Smx~r}+&Oy 7y1Idssɯ<hk+4 {A/58/ʊ)byU{ T1U'\Exʆm:ieYH%X<:H|Z\_i],URIV n5˻I.-՞QFʡKyG$*+/]xi_Xis(O.X1,g J9QKG񎑦z*ڒZpFcL8[&N{ AލwcG?l-ol湶d$8f`*3nc&Wdn,-c{'X8n࢖=N6o麠76 FĎ~5<xlomJ{v)+ ~\7 ,׶sur$yY$pp T\5O't1iV|NҬN63m$&U#9/]%u,K$nNrsLu:4Hp'OJ⿌z?Tw`Y%6pn>q ~'it um.#wȒ2Ѽlc )\9Q71-KJS#?_Ҵ1EAEPh(4Q@mmg'fon oTƟ|1ku-QZZ(/­'M6k pᅵl)>U26 e]^CV7&PQ bs@߆gÛ{id1e`,#Gڊ0Bjߏ|_][7YO:f:(>i^+0u,e[ q"˲2BAGSBP:=۠m_r1`@5@|QXuGOy+yLV9b]QY* Ŀ <=-XxVKx'd/nf@5dmRP-P3̃ ;]@Q-<=q諨Ff.ФL@H2 cF/tuqb.`x>i&ɢ ܌A qN/CN.6ȱ0E0"Sfȉ( NwǞ Ǿ.nn h1Fܬ 60FIkྐp$qyGqgҌP1xWwQX:4w pRa*߇#ef#"YqƑ/$&1Er+m&Eq()VXرBE?+.q/>iu]N:qt3*(cE\#$51@߂q_YJO \e;qG=Fl6>﮾s4'j*¨ 9$QAEQEQގPEPEPE (:@JB3KEakмI:NMaLb0Fuϑ>| C:NC-~C)04n>Mz.( 3=miYl)HYHVIZSNҹN>^ v$UP ݬ*'W!+0953x?BeN`EmSruPhvԴQ@Qր (QEhъ((P endstream endobj 124 0 obj << /Type /Annot /Subtype /Link /A 125 0 R /Border [0 0 0] /H /I /Rect [ 538.8660 309.8363 549.7080 319.7569 ] >> endobj 125 0 obj << /Type /Action >> endobj 126 0 obj << /Type /Annot /Subtype /Link /A 127 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 -101.3093 260.2500 56.9407 ] >> endobj 127 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig8.jpg) >> endobj 128 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 211 /ColorSpace /DeviceRGB /Filter /DCTDecode /BitsPerComponent 8 /Length 14599>> stream JFIF;CREATOR: gd-jpeg v1.0 (using IJG JPEG v62), quality = 90 C     C   ," }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?RP;BǷ5_2g"j}D60u Ew+-g^5-VTWnhX Ć_Iza jOL~lNΩ*y 1pO Xu;Niuo"8SjL-r!дJW>W/6[S(7}h^c:/Q:/Pd{5xÚ<2]ǓzW1?Qcu^Ec [Es4b%Y8e;O4;UͶ3n!d1 r -4ζ"UN9FtRyww X%4 6a&q<GgXBqH5CJn/Kd4c vc4Hn۰C'-v񜌀zf}Fc\i~T |u?`]ŗKO쎣t^Xn߳`?#Kn!B=w֍ZctΪ+0UU"I# tG4xD,t",I >gџc\x68"tURV9 Qmr:8=Ph Wʇ :zX <].M6<'7Vfd=hϱ=x/xMt[]=5)KF"HVeF޽*u!IGyqhž(;$avj7{QrME 9{_~Aig oߏ4M;WЗFlfH%XC  TO^\\[޾,Qk;kE6ZE5g` JMZolvx{!2&v8?3aGr+^úUYgPOMܢ.|M46$QZUQWs1^Iaq1a0;VLqaxM4KAK2Yǘ(lx9foS7D5m+ş |gar<$%ij_t>(!y鍤Aco%?cit2ҴOTmW:Z_ gK=ONHo i)tf41;!RJf>x U'FM3Eh%_ޅm3dwE $l`:(b1@:݇lS]#ip" Ve܊p @'iK!71wc'8uN~xO.aE]p8Xbv#9\d_^O6?f4?X/ 3Gύ7^շ~lf]E^ [XUZ+vc !Ix.$MNcF_IKE5?GWFP>Efk6?f4?X/ 3Gύ * fk_&c&xrh qI/@E&(&iEƀjjv^"]aeb% Eq^_<)ux4IWUWXdka2'm0He~]oqi桨O3]=$Kn[4{[is^^C'CãAJi.uafXC7ŔHI&w-q!mdn?FM@QڌE-俵+т/>қt۷9ϵi%?0X5S*ߊWKRb.i;ZJ\F(%-E(t~)?W9]'?O|i3xqG?B 6vkzNJHgFXESd`c{&;o_D3^KoCi],Zu5p.ɕ0#Yz#Rܱsҧ*wvy]k2h_Ior[[/~9U!['c6έ/\hF\0pv%zh炼FǦ=շ6<)*]؀|OExr=?YL.aӞ]0@i"L |?7-AᯎνOnZG6|^V3dy6V~'xľ$TZVqPJfQkm;b<<璣}'uKo Xcge-K3&lhGKFhV4?6tumm}@b*(dK|΃ںžv|W4并k[(ϜeeXs)'j8~Kgf[k3drό` OzgK@#QʖKobxgj?ޱ}oj7 qvđ2'pvEem76~.!4t()2!ׁ@ >']|AnQ-בֿSwA3̈$ʮK(&l-]V8$C]+zen7ΐw>|@xd  ? W?Z4v H-OQk<"k K5ӼG>vZE$' OM-BRM{mL](X[-ݔ d=B+;nK,y6Kv)^Q"o+?Y}5/;WFP>ן_E|:.P|l?*ߍv>g>}_EoVfR>ߵW?K  W̞3G __}JfZ+y_Eh@Z+ _}EgAk<" _}EgAk<"_}EgAk<"H-OVz(7~y_Eu "Ƴ.0|.æ3XUg=%PqgS$g$2 \K+%-HW;|ļ_9@G#Ÿ%i=E2Kuqw f>7OmrCZF( B;[Ɉ`\ _/uJIdiV-el\Gi8 /W0]:1GP D1o$mM۞s !TԶ^UhZ9E* /$k8|C#my[ɪ>"<4#:̉%L uk??6\׍+J;R_ ÿZZ?wsי%?SrK}O>^շ,ڋI }[\m1rn+)Ȧ}-_/Qch_.m3]zwQ_2{(-QE&h)PE?vO IA@5Y|1u:"CXyjg#]4>&MnΚa[t&KՅɸcWv.o&P-cs5M;u:by\\/SWƯ\l..2^Ml|,&hK.ɧPӯd]B I|݊YT)e,YV7Q u { ǜcy?{\HeX6CUoV~kkh VK [r!w 1o? , ޡ5KԸ$[lK,^6SPj˩BI}jwV8Aqtί$&&DS-56-YP3١}KG͕r{`|(uv"TLE2>D P9_`%h׼8Ǣ%ȸ  EC(l )]zVK@ ^=\ij{8!w >uͲ`N 8ث?l Ǿ#ycB5ۍA~}inBwKDwmu$;(cKmu^ݠ^Bw26ܧO #ѣ-2;Ÿ[絺pHW1#q7`Vgo9+^r-ׅݖ2 I$F N5Wt>Em#GmU!7,p1/iͺ9u2M8zNko& OFZߡI֓N"Iڀ>q~o7E=P'q %OFD0N6\{{OO]h?e,>WM-tg)ӥg-*Rc7t3gEOw,pC(#|ΙY]CA7۔⯗˞;_H~_Ho?F B/\z5JKRQߛG)cstk+V~xR >5!RbxԲ #麾0[hv6/ V͘۱#OIҾ=_.Ց EBcҿm~_B诜=tf5: _F[ߡZXi_BF[ߡZTPo#ZWФkJuEf5: OF[ߡZtPo#ZWФoJu f5: ?ҿk~iRb3s _+fkae8ej';>2j|a0K% F@zI]?j5dzeJܤQKxm-݋bPt LP)h;ԼebJﴹĉ"2#KMnbYOFCt + ŷ?o'ԾhO,, ʅ(gշ 'jKʋʱ?@ZB\kO/9%/ A$?t^]2O> uծ 0DHp8?^soLgǵwd__9gޔw5uA5^%Ie"te- N+n?wjp%vw֫Il? 1^Y+XkUu^ygX,zUo?EZnIS{AMu4웯 O웯 ӣuA5IsA5@tVoMo?7_ TEfdfRdfP%gdfW! ]n+r& ^pK N0\vGN>1<Z&zI]?O:կ~ 뚕̷67*lv OJ2]3 /'&N 86בN5j'Ϻ-Q޽C(EQLREPEP\?l5wF˟ѓQax:Glcֵ+].I)5ܢ5i$('xJU۴}BSSϵ:n?l>螿qk!q“"'Mt=,cܭc?i+\%¿I}^5~X|+\?Zl _¿&}3Q!o+rOE$`n"?VßQ пI<`;'JWխ/z+kigd[_g I:W?kW.' ] 4cRҩop=ωCOgUIKp~kP:68djnQIȅ*b[=+W|m?NuQIh,I9ucGEF<`c*wJ\xK:g sJp8xŶ𶡮Exf.?uF{?̉ 1dҽ?š{\1^0IO!Q& \z7sEWi|Vc"<"'o?]ϖ>*~+)ȵ %8W r#Ag亦}ȦT/&g~$xZZ_Aq{,L--P4RHr=$uѲM8t`2=jԖ&0Gu V UT4>x⧃o;utV<5̬c8!zfBoOt_v'zvFXK zJGOtOˢjcXJJC.@!ᕀr9xi?qb0Ӗtt3O~LJO3u Vh<Q^ث!5k谭aY;C_i83_g95^%٢S'JU7QH$,*վXC)ªz#(SzIYT| |SZu!(ͅ'1R|]o6LҒ_˸Ws戈 P` ;wZS8.s¯' 9`ڕ-:)JXw-$ifAw%L2c_}'M6 +g!X~璥2G[}Nm^lUѕԕeea ygTмUT I2k$7SwfUJ`d>1ռka[/4me:z?Ÿ$?\7SfAs*dAǔxIvWƽ7QYvnIm| p d&-o#+P$? ?d|5񞙭ͪhibIeMۣdgz?8 c:Ś}R,IQ1*@Ʋ#FGcJcW|;[ KIxZN=v!Mwӣa Ƨ^)~_5u BAĭ{us3*5mVAM6p$QK1¨$I$:\>$8@aH!FԐCyʐA 2=9: |-fxZ0x4#DžT^KV [ʸWcLClTH OZCS1I0fo/sdc< dqKoi?;kW&J."14aR@`2jvIeʹSٽ|elE:t; }84f (Q(J1@y3_i/r^Ga2fXo-p9ьh.hfqݿ%m˳x9D;1ٹ'$sҔ=gQŽܖ]\M2S*LH zD5("<O{^wC'ˁOP|mrcĜ}C^-,u?\Zj,KAmsEn#n-e7h Ѵkֺmqx`&qhp1*@8_J天e T^ wo!P]%ʺ-;Z^^xnZ\p.啎Xcv%&uo<y{᧌KouxYpvffޠ( |'WQX>qce5vQ$DxÊAygv> /ĒDGmw7/|Ei5 SK]C%؜!pH x3Mm[v3RG4@,nXx/J-0˱pi6i\Q¨P^m⏋k-u ]Y؋Y$Y#qnϗR6Ǯ=a-wvr$Q` ߐ+W4=jQաE }>)yX ݸ@QX-ĺŽͽww,Ypbb Չ3/l׵+-Ɩ2E4#d\V驦MډdErr6|Ԗ @ {xFGҮnni`/slR8t`|7oX}?T|mf 麆k(l fd+ 3G &Mx~ho|1{ w< mqq(P (9A~^4|R|wjM2jV6o!]8y .O77>2j> ⇰4~[Ϡivd#0E!eBw4Uμ7~[[-Jd튉!r(8c攝&Ig Ld6f}Q,5 Mb{XQ;wn1<\> endobj 130 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig6.jpg) >> endobj 131 0 obj << /Type /Annot /Subtype /Link /A 132 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 386.7262 260.2500 517.2262 ] >> endobj 132 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig7.jpg) >> endobj 133 0 obj << /Type /Annot /Subtype /Link /A 134 0 R /Border [0 0 0] /H /I /Rect [ 538.8660 309.8363 549.7080 319.7569 ] >> endobj 134 0 obj << /Type /Action >> endobj 135 0 obj << /Type /Annot /Subtype /Link /A 136 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 -101.3093 260.2500 56.9407 ] >> endobj 136 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig8.jpg) >> endobj 137 0 obj << /Type /Annot /Subtype /Link /A 138 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 600.9405 260.2500 735.9405 ] >> endobj 138 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig6.jpg) >> endobj 139 0 obj << /Type /Annot /Subtype /Link /A 140 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 386.7262 260.2500 517.2262 ] >> endobj 140 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig7.jpg) >> endobj 141 0 obj << /Type /Annot /Subtype /Link /A 142 0 R /Border [0 0 0] /H /I /Rect [ 538.8660 309.8363 549.7080 319.7569 ] >> endobj 142 0 obj << /Type /Action >> endobj 143 0 obj << /Type /Annot /Subtype /Link /A 144 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 -101.3093 260.2500 56.9407 ] >> endobj 144 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig8.jpg) >> endobj 145 0 obj << /Type /Page /Parent 3 0 R /Annots [ 147 0 R 150 0 R 153 0 R 155 0 R 157 0 R 159 0 R 161 0 R 163 0 R 165 0 R ] /Contents 146 0 R >> endobj 146 0 obj << /Length 15844 >> stream q 15.000 30.512 577.500 746.488 re W n 0.965 0.965 0.965 rg 26.250 747.845 555.000 29.155 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 747.845 m 581.250 747.845 l 581.250 748.595 l 26.250 748.595 l f q 35.250 759.095 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 767.476 Td /F4 9.8 Tf [(Fig. 8: Distribution of ambulatory patients with and without steroids by age.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 536.440 555.000 203.905 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 740.345 m 581.250 740.345 l 581.250 739.595 l 26.250 739.595 l f 26.250 536.441 m 581.250 536.441 l 581.250 537.191 l 26.250 537.191 l f q 225.000 0 0 159.000 35.250 571.595 cm /I23 Do Q q 35.250 547.690 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 556.071 Td /F4 9.8 Tf [(Fig. 9: Distribution of non-ambulatory patients with and without steroids by age.)] TJ ET Q BT 26.250 519.417 Td /F4 9.8 Tf [(Genetic Mutation Status)] TJ ET BT 26.250 500.012 Td /F1 9.8 Tf [(Dystrophinopathies are caused by a variety of types of mutations in the dystrophin gene \(exonic deletions and duplications, a )] TJ ET BT 26.250 488.107 Td /F1 9.8 Tf [(range of smaller mutations within exons, as well as rare deletions to non-coding regions\). Molecular genetic testing for )] TJ ET BT 26.250 476.202 Td /F1 9.8 Tf [(Duchenne/Becker has experienced vast improvements in the past decade, and is currently a recommended aspect of )] TJ ET BT 26.250 464.298 Td /F1 9.8 Tf [(confirming a diagnosis of muscular dystrophy \()] TJ ET 0.267 0.267 0.267 rg BT 227.275 464.298 Td /F1 9.8 Tf [([1])] TJ ET 0.271 0.267 0.267 rg BT 238.118 464.298 Td /F1 9.8 Tf [(\). In the registry questionnaire, participants may enter the type and location of )] TJ ET BT 26.250 452.393 Td /F1 9.8 Tf [(the causative mutation. This information is curated by the DuchenneConnect Coordinator. We encourage all participants to )] TJ ET BT 26.250 440.488 Td /F1 9.8 Tf [(submit a copy of their genetic testing report, which is reviewed by the Coordinators and results are entered into the registry )] TJ ET BT 26.250 428.583 Td /F1 9.8 Tf [(using the standard nomenclature, according to the NCBI Reference Sequence \(NM_004006.2\). Of 1756 participants, 1,432 )] TJ ET BT 26.250 416.679 Td /F1 9.8 Tf [(\(82%\) indicated they had genetic testing, and 234 \(14%\) indicate they have not had or were unsure if they have had genetic )] TJ ET BT 26.250 404.774 Td /F1 9.8 Tf [(testing. Ninety participants \(5%\) did not indicate whether they had genetic testing. Among 682 who submitted results, the )] TJ ET BT 26.250 392.869 Td /F1 9.8 Tf [(DuchenneConnect Coordinator determined that 34% \(232\) warrant additional testing to further identify or interpret the results. Of )] TJ ET BT 26.250 380.964 Td /F1 9.8 Tf [(988 participants who described the mutation, 35% \(354\) have not submitted a copy of the test report to DuchenneConnect. For )] TJ ET BT 26.250 369.060 Td /F1 9.8 Tf [(the Duchenne group, 74% \(612\) of participants report that results of genetic testing described a deletion one or more exon in )] TJ ET BT 26.250 357.155 Td /F1 9.8 Tf [(size, whereas in Becker 63% \(34\) report a deletion one or more exon in size. Duplications one or more exon in size are reported )] TJ ET BT 26.250 345.250 Td /F1 9.8 Tf [(by 10% \(79\) of participants with Duchenne and 11% \(6\) with Becker. See Table 3 for a summary of mutation status by )] TJ ET BT 26.250 333.345 Td /F1 9.8 Tf [(diagnosis. Participants who have not had comprehensive genetic testing \(i.e., testing able to identify less common types of )] TJ ET BT 26.250 321.441 Td /F1 9.8 Tf [(mutations\) may lead to an over-representation of more commonly detectable mutation types.)] TJ ET q 450.000 0 0 139.500 26.250 172.060 cm /I24 Do Q BT 26.250 155.036 Td /F4 9.8 Tf [(Table 3. Types of gene mutations by diagnosis \(n=912\). Key: Deletion & Duplication refer to mutations of one or more )] TJ ET BT 26.250 143.131 Td /F4 9.8 Tf [(exons in size typically detected by array, MLPA or similar technologies. All other mutation types refer to smaller )] TJ ET BT 26.250 131.226 Td /F4 9.8 Tf [(mutations typically identified by sequence analysis or similar technologies. In/del refers to co-localized insertion and )] TJ ET BT 26.250 119.322 Td /F4 9.8 Tf [(deletion of base pairs.)] TJ ET BT 26.250 99.917 Td /F4 9.8 Tf [(Pulmonary Status)] TJ ET BT 26.250 80.512 Td /F1 9.8 Tf [(Individuals with DBMD experience progressive deterioration of respiratory muscle strength resulting in complications such as )] TJ ET BT 26.250 68.607 Td /F1 9.8 Tf [(insufficient cough, hypoventilation, and ultimately respiratory failure \()] TJ ET 0.267 0.267 0.267 rg BT 321.577 68.607 Td /F1 9.8 Tf [([2])] TJ ET 0.271 0.267 0.267 rg BT 332.419 68.607 Td /F1 9.8 Tf [(\), and thus tracking of pulmonary status is a core )] TJ ET BT 26.250 56.703 Td /F1 9.8 Tf [(component to care. Of 1552 patient participants, 554 \(36%\) report they have had a forced vital capacity test \(a minimum )] TJ ET BT 26.250 44.798 Td /F1 9.8 Tf [(assessment of pulmonary function\), 826 \(53%\) have not had a forced vital capacity test, and 172 \(11%\) are unsure whether the )] TJ ET Q q 15.000 30.512 577.500 746.488 re W n 0.965 0.965 0.965 rg 26.250 747.845 555.000 29.155 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 747.845 m 581.250 747.845 l 581.250 748.595 l 26.250 748.595 l f q 35.250 759.095 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 767.476 Td /F4 9.8 Tf [(Fig. 8: Distribution of ambulatory patients with and without steroids by age.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 536.440 555.000 203.905 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 740.345 m 581.250 740.345 l 581.250 739.595 l 26.250 739.595 l f 26.250 536.441 m 581.250 536.441 l 581.250 537.191 l 26.250 537.191 l f q 225.000 0 0 159.000 35.250 571.595 cm /I23 Do Q q 35.250 547.690 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 556.071 Td /F4 9.8 Tf [(Fig. 9: Distribution of non-ambulatory patients with and without steroids by age.)] TJ ET Q BT 26.250 519.417 Td /F4 9.8 Tf [(Genetic Mutation Status)] TJ ET BT 26.250 500.012 Td /F1 9.8 Tf [(Dystrophinopathies are caused by a variety of types of mutations in the dystrophin gene \(exonic deletions and duplications, a )] TJ ET BT 26.250 488.107 Td /F1 9.8 Tf [(range of smaller mutations within exons, as well as rare deletions to non-coding regions\). Molecular genetic testing for )] TJ ET BT 26.250 476.202 Td /F1 9.8 Tf [(Duchenne/Becker has experienced vast improvements in the past decade, and is currently a recommended aspect of )] TJ ET BT 26.250 464.298 Td /F1 9.8 Tf [(confirming a diagnosis of muscular dystrophy \()] TJ ET 0.267 0.267 0.267 rg BT 227.275 464.298 Td /F1 9.8 Tf [([1])] TJ ET 0.271 0.267 0.267 rg BT 238.118 464.298 Td /F1 9.8 Tf [(\). In the registry questionnaire, participants may enter the type and location of )] TJ ET BT 26.250 452.393 Td /F1 9.8 Tf [(the causative mutation. This information is curated by the DuchenneConnect Coordinator. We encourage all participants to )] TJ ET BT 26.250 440.488 Td /F1 9.8 Tf [(submit a copy of their genetic testing report, which is reviewed by the Coordinators and results are entered into the registry )] TJ ET BT 26.250 428.583 Td /F1 9.8 Tf [(using the standard nomenclature, according to the NCBI Reference Sequence \(NM_004006.2\). Of 1756 participants, 1,432 )] TJ ET BT 26.250 416.679 Td /F1 9.8 Tf [(\(82%\) indicated they had genetic testing, and 234 \(14%\) indicate they have not had or were unsure if they have had genetic )] TJ ET BT 26.250 404.774 Td /F1 9.8 Tf [(testing. Ninety participants \(5%\) did not indicate whether they had genetic testing. Among 682 who submitted results, the )] TJ ET BT 26.250 392.869 Td /F1 9.8 Tf [(DuchenneConnect Coordinator determined that 34% \(232\) warrant additional testing to further identify or interpret the results. Of )] TJ ET BT 26.250 380.964 Td /F1 9.8 Tf [(988 participants who described the mutation, 35% \(354\) have not submitted a copy of the test report to DuchenneConnect. For )] TJ ET BT 26.250 369.060 Td /F1 9.8 Tf [(the Duchenne group, 74% \(612\) of participants report that results of genetic testing described a deletion one or more exon in )] TJ ET BT 26.250 357.155 Td /F1 9.8 Tf [(size, whereas in Becker 63% \(34\) report a deletion one or more exon in size. Duplications one or more exon in size are reported )] TJ ET BT 26.250 345.250 Td /F1 9.8 Tf [(by 10% \(79\) of participants with Duchenne and 11% \(6\) with Becker. See Table 3 for a summary of mutation status by )] TJ ET BT 26.250 333.345 Td /F1 9.8 Tf [(diagnosis. Participants who have not had comprehensive genetic testing \(i.e., testing able to identify less common types of )] TJ ET BT 26.250 321.441 Td /F1 9.8 Tf [(mutations\) may lead to an over-representation of more commonly detectable mutation types.)] TJ ET q 450.000 0 0 139.500 26.250 172.060 cm /I24 Do Q BT 26.250 155.036 Td /F4 9.8 Tf [(Table 3. Types of gene mutations by diagnosis \(n=912\). Key: Deletion & Duplication refer to mutations of one or more )] TJ ET BT 26.250 143.131 Td /F4 9.8 Tf [(exons in size typically detected by array, MLPA or similar technologies. All other mutation types refer to smaller )] TJ ET BT 26.250 131.226 Td /F4 9.8 Tf [(mutations typically identified by sequence analysis or similar technologies. In/del refers to co-localized insertion and )] TJ ET BT 26.250 119.322 Td /F4 9.8 Tf [(deletion of base pairs.)] TJ ET BT 26.250 99.917 Td /F4 9.8 Tf [(Pulmonary Status)] TJ ET BT 26.250 80.512 Td /F1 9.8 Tf [(Individuals with DBMD experience progressive deterioration of respiratory muscle strength resulting in complications such as )] TJ ET BT 26.250 68.607 Td /F1 9.8 Tf [(insufficient cough, hypoventilation, and ultimately respiratory failure \()] TJ ET 0.267 0.267 0.267 rg BT 321.577 68.607 Td /F1 9.8 Tf [([2])] TJ ET 0.271 0.267 0.267 rg BT 332.419 68.607 Td /F1 9.8 Tf [(\), and thus tracking of pulmonary status is a core )] TJ ET BT 26.250 56.703 Td /F1 9.8 Tf [(component to care. Of 1552 patient participants, 554 \(36%\) report they have had a forced vital capacity test \(a minimum )] TJ ET BT 26.250 44.798 Td /F1 9.8 Tf [(assessment of pulmonary function\), 826 \(53%\) have not had a forced vital capacity test, and 172 \(11%\) are unsure whether the )] TJ ET Q q 15.000 30.512 577.500 746.488 re W n 0.965 0.965 0.965 rg 26.250 747.845 555.000 29.155 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 747.845 m 581.250 747.845 l 581.250 748.595 l 26.250 748.595 l f q 35.250 759.095 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 767.476 Td /F4 9.8 Tf [(Fig. 8: Distribution of ambulatory patients with and without steroids by age.)] TJ ET Q 0.965 0.965 0.965 rg 26.250 536.440 555.000 203.905 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 740.345 m 581.250 740.345 l 581.250 739.595 l 26.250 739.595 l f 26.250 536.441 m 581.250 536.441 l 581.250 537.191 l 26.250 537.191 l f q 225.000 0 0 159.000 35.250 571.595 cm /I23 Do Q q 35.250 547.690 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 556.071 Td /F4 9.8 Tf [(Fig. 9: Distribution of non-ambulatory patients with and without steroids by age.)] TJ ET Q BT 26.250 519.417 Td /F4 9.8 Tf [(Genetic Mutation Status)] TJ ET BT 26.250 500.012 Td /F1 9.8 Tf [(Dystrophinopathies are caused by a variety of types of mutations in the dystrophin gene \(exonic deletions and duplications, a )] TJ ET BT 26.250 488.107 Td /F1 9.8 Tf [(range of smaller mutations within exons, as well as rare deletions to non-coding regions\). Molecular genetic testing for )] TJ ET BT 26.250 476.202 Td /F1 9.8 Tf [(Duchenne/Becker has experienced vast improvements in the past decade, and is currently a recommended aspect of )] TJ ET BT 26.250 464.298 Td /F1 9.8 Tf [(confirming a diagnosis of muscular dystrophy \()] TJ ET 0.267 0.267 0.267 rg BT 227.275 464.298 Td /F1 9.8 Tf [([1])] TJ ET 0.271 0.267 0.267 rg BT 238.118 464.298 Td /F1 9.8 Tf [(\). In the registry questionnaire, participants may enter the type and location of )] TJ ET BT 26.250 452.393 Td /F1 9.8 Tf [(the causative mutation. This information is curated by the DuchenneConnect Coordinator. We encourage all participants to )] TJ ET BT 26.250 440.488 Td /F1 9.8 Tf [(submit a copy of their genetic testing report, which is reviewed by the Coordinators and results are entered into the registry )] TJ ET BT 26.250 428.583 Td /F1 9.8 Tf [(using the standard nomenclature, according to the NCBI Reference Sequence \(NM_004006.2\). Of 1756 participants, 1,432 )] TJ ET BT 26.250 416.679 Td /F1 9.8 Tf [(\(82%\) indicated they had genetic testing, and 234 \(14%\) indicate they have not had or were unsure if they have had genetic )] TJ ET BT 26.250 404.774 Td /F1 9.8 Tf [(testing. Ninety participants \(5%\) did not indicate whether they had genetic testing. Among 682 who submitted results, the )] TJ ET BT 26.250 392.869 Td /F1 9.8 Tf [(DuchenneConnect Coordinator determined that 34% \(232\) warrant additional testing to further identify or interpret the results. Of )] TJ ET BT 26.250 380.964 Td /F1 9.8 Tf [(988 participants who described the mutation, 35% \(354\) have not submitted a copy of the test report to DuchenneConnect. For )] TJ ET BT 26.250 369.060 Td /F1 9.8 Tf [(the Duchenne group, 74% \(612\) of participants report that results of genetic testing described a deletion one or more exon in )] TJ ET BT 26.250 357.155 Td /F1 9.8 Tf [(size, whereas in Becker 63% \(34\) report a deletion one or more exon in size. Duplications one or more exon in size are reported )] TJ ET BT 26.250 345.250 Td /F1 9.8 Tf [(by 10% \(79\) of participants with Duchenne and 11% \(6\) with Becker. See Table 3 for a summary of mutation status by )] TJ ET BT 26.250 333.345 Td /F1 9.8 Tf [(diagnosis. Participants who have not had comprehensive genetic testing \(i.e., testing able to identify less common types of )] TJ ET BT 26.250 321.441 Td /F1 9.8 Tf [(mutations\) may lead to an over-representation of more commonly detectable mutation types.)] TJ ET q 450.000 0 0 139.500 26.250 172.060 cm /I24 Do Q BT 26.250 155.036 Td /F4 9.8 Tf [(Table 3. Types of gene mutations by diagnosis \(n=912\). Key: Deletion & Duplication refer to mutations of one or more )] TJ ET BT 26.250 143.131 Td /F4 9.8 Tf [(exons in size typically detected by array, MLPA or similar technologies. All other mutation types refer to smaller )] TJ ET BT 26.250 131.226 Td /F4 9.8 Tf [(mutations typically identified by sequence analysis or similar technologies. In/del refers to co-localized insertion and )] TJ ET BT 26.250 119.322 Td /F4 9.8 Tf [(deletion of base pairs.)] TJ ET BT 26.250 99.917 Td /F4 9.8 Tf [(Pulmonary Status)] TJ ET BT 26.250 80.512 Td /F1 9.8 Tf [(Individuals with DBMD experience progressive deterioration of respiratory muscle strength resulting in complications such as )] TJ ET BT 26.250 68.607 Td /F1 9.8 Tf [(insufficient cough, hypoventilation, and ultimately respiratory failure \()] TJ ET 0.267 0.267 0.267 rg BT 321.577 68.607 Td /F1 9.8 Tf [([2])] TJ ET 0.271 0.267 0.267 rg BT 332.419 68.607 Td /F1 9.8 Tf [(\), and thus tracking of pulmonary status is a core )] TJ ET BT 26.250 56.703 Td /F1 9.8 Tf [(component to care. Of 1552 patient participants, 554 \(36%\) report they have had a forced vital capacity test \(a minimum )] TJ ET BT 26.250 44.798 Td /F1 9.8 Tf [(assessment of pulmonary function\), 826 \(53%\) have not had a forced vital capacity test, and 172 \(11%\) are unsure whether the )] TJ ET Q q 225.000 0 0 159.000 35.250 571.595 cm /I23 Do Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(6)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Muscular Dystrophy)] TJ ET Q endstream endobj 147 0 obj << /Type /Annot /Subtype /Link /A 148 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 571.5952 260.2500 730.5952 ] >> endobj 148 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig9.jpg) >> endobj 149 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 212 /ColorSpace /DeviceRGB /Filter /DCTDecode /BitsPerComponent 8 /Length 13746>> stream JFIF;CREATOR: gd-jpeg v1.0 (using IJG JPEG v62), quality = 90 C     C   ," }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?R(( -@(2SW:? qt[J5]FoX==-l.ד,wL"}c}gB/KE>{ llg8b'$-Կlo Tolt&%air/IgTm Hln[?m߈~5泤XR1i۴bz 2*2usf} Yml؈invׂxW$8[~ `,$k H6ZO#Mc+I3Կm}/H]ۣy"kYn#9*O k~+_=FT뺴{^!i1+:A<`hnoi^h,=sH-.l̝fv@?e;'+&"$'ݻ=q^{ny$>g W6f#C"HB5oUxBJ$g;8唶rD1dl$r@^>bn;]q%e˨;!{BZHsn=^Wȷj =w4{ \O4>tr2hHr l׉ IF_kwMZ2+Ό۝ *V>uo߄Gm_im%jC͊ ILN] ǃ7gck 1k/6 U,{)̂$Ѥ7W( 95mY@׶ M+EDյ;]GQyH u )faz?(|AfEjz3G|I-mu%K0{Rd+JH"_(5]+L𶠷wq][.p,HI#2k5MV;HnuN8rZK Ilt^c'㍏[.tҵI4mnV*o2ȤrA NQGJ(J)h\4M:"m)8ޙgyiA+f̷77sFuEH*% :`€}Fk`~E؟I:ۙ6NXGI>M 6X%!m" ~tQ\w&:l= 4~xR/ h[\ KK89 pFCs޳1ghUM =?>og{-ڤ$y$t|;ڼ?l ς<ӅHד5 @?3G&:l=ki^慧\in Vk[K(PsȪxV:<|i+-Fh`w&:l= 4e/ ZxsI%І$Dۑ槹~yusuqiܫ$Ki<2z_Lu_{?1ghN^úMۑx}OªFWU]pgVW>xK?-gF{+/3[/.$f&xВʹg4Lu_{?1gh~&/ i>д4[EI ;1sDtM>AIL,"ͮKgoɸNg'5 @?3G&:M <-[OmaźM[ I U*0fO1,]۪3"U$V@1&1ghUM ׿ |#WE#HV9]DibW7u³^\IRy#$@ AY 4c&Wzo]6|1 rsZio _}m*kw-VQMk0\øySY? 4c&a YLK]z}ORsq.<`1CA糟T4Jk&k%ݤrP;OOLu_{?1ghR~-sAQ:$ϙݎxO|Ik6w~ӱ{<6җg2( ˑ~rj/Lu_{?1ghM?'?Oz ̖!dvSMhWgpH8r M{ %2\F:$f!]T0kxu-MSNE0si˳k%Y7T9g'p7s]q^0Cj?l-CȠHpR2SΔ\Qm,^4 $!]E,nRDae#G+OԿo] ZWL6#$Vyُ$bOָItm>Ri y!Vcѣg92(sJeP@?O'@8ҿg;2(F#KZ? t #hZl dNU`PT+ 2e<v_}]gm#);%@;z׹i 2+Mz/<]8+_o:m m]ncT0浾 67$Ǖ"OQҿg;2+ΓCҊsJ]Q@?O ZsIeQ@?O +?'G#O,?€4(GtY:? t Тg;2(BwIeP<;?OLQG|cx'5T[THdn4*g!DPIF-AxR;K|}JTy;|2y  z/,c& /o$Uhf;gÿ[7u iWe77F rYL}(€8RG@_i:0sN)w+PX(R?Rٿ#]x+6 )A1JF8ʲ 5ħ~_7hJ( ( =( >%ȏ!-t|KWCBZ~l)G#՟qA}I#՟qA}^WQO!W_ "Ρ__u,**#@z8K^W:.Z& Z}8_IREJz(z*;YmvnsԵԵԠQҒ-%-QI@ EPE%-s_Mg4cD;G[wECN(^i> j|KݝՆ.m9pC$e] ?IB WPο X-5˵Y6p~?^Ԯ3E,/0Jŗj"`?G^TL Yuf3[@H984u 5]Ny.-K($dyd[BCC(DH*(*&?Ŧ&Ko-a*FH <ahP? KM'[ۉn'h򑥚V*r,N;ҠԵ9UA+kΓ?u/B4O zt]/ Т3Om=o?:.h +oyta[[(; zt]s{x<=uf_:51/D}_ k 2elKod7GVs\Ue`*ǯx{]8+co:EE^=/F jt+oyu󗌡[}\Kb͍ǩ$ӤW̾8_3FOEVQ[:1)ٽug zt]Oi:*}TU; zt]VF@ga[[ zt]h@V¶?Zm=o?:.+oyuEga[[ hV[3uCCh隅ޛp!wMrF ߵr߲7}~ں^7rNS"\.N3һ#n}4mmsj D𷅵Y52KL}NV[T0CN[i*[n'Q:|ksڼb8!l3yjwEݍ7`W᎑Cf4 AO b&mO1K}0'+f Ӆޙ$<%^&3,K"mf ː#8Ȯ9uusY;.bJĠ;k@ G_J(O8אbYDl͕),$RD6هlYC)$8`\IU rG^+?u/B5·zuV'mI0[,< dP0QNsR˩jm3{6D J>}A6 @>Vwo&h -hg}m~u&1r1 pFB+*aJrJ[#KZa߅o5~ YD`Tdnf~Rٟ%]N_McO|Aac" 3ׯ3x'^0ݵjTFE?WȊ?fש|zs>,xuy14!=ztrn3ܠ\s|G C赯?'gT$a]߱+ٵ/ w2yPK# Ȥ=|\6s=^WQ >܅WݭxOWkxZ̫tW_ k_\|zG#~lZI% _"|D:E|C~"6 "Go־}!yW_ ?yg%\/|k+&sa<7rKn$1ƤgkLEjtu%dٛinvھR1%SS^JVhZ\ylz9|q"f^-|m a.u ><"?W~]Aj=[$A>ѷQ5-wJ1@ţRR#Z~!. ֆhK2%vsſGח9ל3xSSuuh"wD90;GzO?vvmͯ[i`]I\c_Z ~ =sCj+5]dh%v1~"\kotKx""<͇{p=4MrX Rg2JOlzjɿtgkέ]4aִPwfn|Jm#-vęQq Cto1Gݏ*~ 46E[;_n?yg?b+j_7 ,qez?7> ׵+Sޛ=}B[FxW13k\8ϼ#$]4hxjz\.e<9i e2ڬ pq3\~X򭎒2Bʀ )KެAE%-QE%(@58:1[eA)%rz;՘bX"HB" 0Gzd2V *1hb>dӎ80ʑ§ӭU9Nಠ`=)GBf1B?ұhvVlok.P4q*3d{YtcYfaشjX-/fy]Jq־V?H\Qptk8lLk(4Xd}TFr-%I^y0YОڪZ^Gi)6H!G*G;XӨx}+G :ܽkW)eQWay®)xQ> \-}^m< 7W "30Yൄ IdUI:5\_`==WbfNq~ Zq0H,-uK"4GTۮqL%fX,#e.#H`1a0R}ΥZj71QXԎmVUHd qaFbG}?2<Gӓ0iEP 9z}+;w> endobj 151 0 obj << /Type /Action /S /URI /URI (http://@references) >> endobj 152 0 obj << /Type /XObject /Subtype /Image /Width 600 /Height 186 /ColorSpace /DeviceRGB /Filter /DCTDecode /BitsPerComponent 8 /Length 30207>> stream JFIF;CREATOR: gd-jpeg v1.0 (using IJG JPEG v62), quality = 90 C     C   X" }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?|/υti,n( $&OE}/+K?&?Z_Q[VUU%i3Q_GWº+oTeOGWU> _Ke (⏫TXTx7}/(Q_(/AOGWU _Ke (⏫TXTx7}/(Q_𮳊0(/AOOWU _Ke 8bTXTx7/(Q4_𮳊8+;9?U _Ke ?Tx7}/+>KP}bQ_GXº(⏫TXOO icݗ+?o}mt n)&Vhem|Q]?xCVI}>V5 rh%M iW:shtDtm֓XӘKT gqo쁤[AIu9tҶVbT|f4@:mۼL??߻kjІ4RjϩηncXAyTWT>joZ*hڧp ӿ޼u~~>y}gi p_A89]~6_>EKyoOv)l2d߽fv C^3E.DFfp7A*+gRO2S^Z ^-<5Kp1It]&iLc)kSp#p`a;5]¾9eozvF)c;>`L߶{--HiWV|6Gn+nڛGFIӭΝ*kEӨx:Lzt=E=iF ۀA^κf`VѮ%1B'a2)ۿ&c펽Wǟ.Kf5eC(F+JXu{>boX,/g:K 6msV~ɶ- .lnYHl!;H'{eui骴cGOe*(MC|^ӭzVsK*8uk@{ K֔A7`uNWۂI晪t%~M3^bQ/^:BXg鬬,fwCi [1xscqaշ`̳E˪.6ݱ*:~ U)jo~ʖ> :Ld2_;yseoxӴ .Qio T<"|{ѭ5k[]VX.?#''^uoG[Z[mct#r&6qIBE9i4V78*뮧1~nR[EAgK> rG3h5dmDne"]8G#pH=5ǭ?V!L/yX.1̘#=}M ݛ-?Q[^UY]cʏcd\VQּVi=-Q\VVjOCf.tRcq ޴f,ZM[Ѩ 72N2Fk<7ZUԮdxaye(VbrN~ut3i3A5:,\,wgAO'ob9:i_?UuKiL`1v,a}gkx:AX5; x(I^G ΍7c=:lVҺ [fV"嶞Oq>;+M-u}t\άO##v85[8c/LD 6"p I!1U9Yi6Y WdLq908_?B=k|++I>(X\_k\i) xUbAPG|]&EƵ}qy%6U\aTeǎ3dZ)?Ors{Fg4FWTp/ONq3s1?f:F{]S#t,a`ogu M8ZEiAoY7n39:#P,$ePn;cS21FXh%C9r%W5^ww׀(;K.cXmg*0}o~@@𾑥]4 rNjbUWy''8澂>0z4-:AtԦe\\AHR;+>(XXK ̶isGlFR0)j)ʬ(ʒM-9E*CBʺ+vV,yǹYr2 w8y_n`y# &W8J?:Ci7i5'%(,NF= &ɣغi.bbZIw9fpC9bF9RF#X9*|Ϙᘡf? %FWFrߑv߳wmwq Bq*id$uvq?UӵYu}徝-bnwdОO&57W:,h< sWeeO)'gU~:V}BQ W:c Pvn~hVZ]qkx4tK"㖉kqዙl54g- I 8oF _Ke ?T7}/+XT7}/(S_bTXT7}/(S_bTXT7}/(S_bTXT7}/(S_bTXTx7}/(S_bTXT7}/(S_bTXT7}/(S_`Qz_ʃ*Я2|BbQz_ʃ*Я2|BbQz_ʃ*`/کWU\Թvw1|"n^赭WxA-m޻hSC~^\QIA>\QIFG RdzёG, F)2=hȣ}#֌Z>Ag\QLZ2=haqE&G RdQG,ŢLZ>Af.("Y#֌ R#֌Z.ϰdR PI'i2=h@}ȥϽ/Y\RfZ{4niÚ9ȣ#֍{ b#֌ZA )2=hϽ }sj`c^gތb3F}݅`#>ԁ1Kz3G9_aiތџz>Aџz3IiVgތӻ_!hϽbIz3G, I3F}ahϽ}>gޏYLZ3G, E&}ȣbIz3Z>AgZ)3F}ahϽ`zQF29juNǍc&*T&(Qm!Fq+G_%i?=_52I$+c G89#iGnUGS|{8Oih{AO&C!0M?#hCA&5.7~.l?b__%i? $Mh?ӿ?&\ox̓G'4 K4K=Ŀ ']"4 wGˍ9/?b__%i? $Mh?ӿ?&.7~#_%i??b_ wG@M;#ir{lK8Oih{AO&D4i G"4ˍ9{AO&_?']!t w4~#ҿiqY?CK>^ '^࿅<ᵾ$#nbmӎ1.qcaac,`7̨FT*y֧QӜ⭦X|<>e|?-7IK|> '_Q?=y]h&kZb(.ҿْW,yrx7߳/^M: ->S4qwEV8'k08j+zo>i{AO&ike-XԚd\I5aM Aq <\ƧYkƙo JM+湚6PFtSԨcR72*Tx4 K4K=Ŀ ']! O=#h;B&5ˍh7+_%i??b_NH? $M̓G'4 K4K=Ŀ ']"4 wGˍ9{AO&ikCA&4NH9q6%'4ڼ '@Gm']'DӸ#kO_fMbLp@h9qӥrWb0*Zӧ~H?{[Y??᥾K5$?΋@ fmQhWo2pwd;t3cCuiWos$Wv-@19@'8Ȭ>kj#eϗ/v~-/Ig쵧j#_GRHwC$gorxuh𭕍}\[j,Ij"&vL~<sJy#^1/I -4M}k=VƸY ůy9ϗFRFkվZkViZ-kb`~`0AȭR\*4"*o<[_%i??b_oJɡX#m##?п $Mv:J/a̓W'4 K4K=Ŀ ']"4 wGˍ\?p1/I /4Mwh?ӿ?&D4i G.7~${AO&ikCA&4!NH9q6%'4 K4K=Ŀ ']"4 wGˍ9/?b__%i? $Mh?ӿ?&.7~#_%i??b_ wG@M;#ir{lK8Oih{AO&D4i G"4ˍ9{AO&ikCA&4!NH\_%i??b_ wG@M;#h?yK=Ŀ 'G4 K5!NH? $M_%i??b_ wG@M;#h?yK=Ŀ 'G4 K5!NH? $M_%i??b_ wG@M;#h?p1/I /4Mw?ӿ?&C/i G.7~+_%i??b_ wv@M;ch36%'4 K4K=Ŀ ']!4 Gˍ9{AO&ik?A&4OH9q6_pj:O𢻯C>mO}>GErUxA\tLoNOxAֶ^#ƭIzVAKI׵-b(Q@ E+v)(`-fx_Y嶂卢@YA :=ΞxI$n|e$;q\+Q[[屁9Wv#E Hep݈\Ӎ9pMg.e?Ŀ e/_6;H Lvu< ic1A`1w\kڔ2H@ڽK~&5XZA5Үlcd.~#ǵzXZst_ˈN G^Ni1-^ƈP("@r(G\Z1H4pqU|SN%ƪfQ8b2f8rƓөg8ƑѴߏ'jRkah"yB0^Eo9P xds$,6ӷyx_:`!+=KĞ!Wu#Y0KR!-"S\D)ad)_sY4ZǘCv]i$b,6So~cNo[iafVlĘ{1C ؐ3wuY6=:e\Fd`dt&6RuHێ1k zTok9.C'$7K!d޸g^(ktƌ]ϋeMfV6MF91/B26'@B5#ʕI.j\QIkC!qE&(Qj-8^۠)i3FiqE&i7 㨣&ihKIi7)=GbJ(RQK@RgHaqRfI3@ I4j.(KEŨRmq )4/2'Q`+B^u}FQ>Gxcr$"?tT'f+2t(W>y x-'F2HRq;Oҫa9ZV_iFK>Kt+!݁0yk'Atn>f]7-w$(MkΎg+*lx5x8qF1]GĴїw@XSMeR](Ox\yzk|$7=8lEph9䪓h?&?Z7$j寇DeH/hԩqWG 'гr~f'~/YZ4Iw+=~K+M <`sck|)?iIS6WͨsD<gTE焒՘HU|P#ׅ<ʬjKqj]B8Hr(~z,&t>ׅ]\ m'G$dkaӭDoo(..'ƣ ,REYfU:y7ou_Ki;O$.ЎX+݂ R8=xR[+mFxVr+ lڋ_[Y-[GBDK /iIb$qG_o)<,=ē[l)g-zpٟ4%W^37][Zo}<1y$eWjeT2f-H4KYݡ4.*fÿ~*n ^8|$ JH_Qz>As]~ n/$ԠKcnXk*S~Qq* M3aEi|=w%$m(:Ȼyi_|Y:_XGl֖l>l- NAF1׵{׀~)^ds`f۶$F]CdWu Z׮|<6XK`ڱ$|܂\uN |D.oOԭI0eRc+;W{-FUӦpH!P8$WаxGs$Y}F- | 9?|+M*c:6 [5T:INQ3)^);Wxo"AѮνmgI4VS8*d 2:V2~W<;q?il/b r[`kzfyWhadgSL"K~[n%}&VsZW]f}&HmdYG2r:l( &(QP$6U<ݹ9sW^-;vaޑEf-sJKLNXƣMy+KN+授aZg|,n 6YEpv%ur ng=í>ydiXWǁ6|d`w~,wW:YycA?:%ENg_|.%w<}c,7 X_[Y]F .28'G_Z -;1"%y|# m<b'E5CO|0d oH9jcQn5N5ްg)uk0M<HGwo/-<9_i؈%2E Kp$fX2y@[g|_P7'pҟm-wG歟[H^?YEsͥQęl.P^#̪[Sgc I⋉\&#J%BO/'7F9zw-dH^n7)am cOx%w?Vvd  +(3|'(o|XK멡{gVqm ϝ<Yi?<22(ٔJ2]ˎ~l\)BUpG}Fa{Kkta"5E),cy5^q, #uC &߷W櫃i/e%5 o جcEYqzO??şZVf YB'CnEria*7i'ᆬ|UC.蓮mץ[Yk[_/-t%݆$##׬'oO໫7𧕩td[beif'*5k៌61Z=죿KcMf2A+ɖeZKݜ~v$V3~zFѾqE2I&̆==+'}3|Yeh H"(M ) H#y( xdWbz9a'̽]9 {K}]>oq$<.wY Fv.c9 '>?`ەL M13@n9o>0鉥-l'i|52\CkN.hqm^-oŷ7VH$"COCW Юx~ר{&'Zߋ+ԭbA?txU^G (^/.SF&YBs7˕@K̫6nY]ZŠ<&C&vl`\o+*BU uq"6=z'[gwUJI]IJGf7Wmq#JUoHY]\i/S {8P/|+ zCK+ =plng[M5R4QEdT-0K:ױ#t=<E5퉈@x2*ojk់O[JmԦ#DL,6<ל*5ꎧVh~x\hm.@c9'jݷ/AK5J&%0sc9׊;_62;3iDw+!R _8\ j;|a %ڴOn\e'ixVmYl'PϟΈ45`e 霨±ŸJ4G-*zGWZo0iim%i<5YJf! @5ooSϔ (Rz3KsӥuP\~QQ2/<ukV16Jο5mbͅ55/}:MR8!Y'pC ܅_ | Kt "<ͨ[6/o =_5 {`d wfQVUa@nTX̧ԋMJ. -3ōgctA|b[v]Fc8>$ |W,ǣO#ِ&TJH?1+5kOTw\ VIԅI1;[+( y +bKk6JêEDBŖl KwծKџ:¿5ozb[w@(|9w纼FI1**X98\׸A?<$.v[A!8lr=G[Zw[9`t"U&6n.Jo6B>JI^'6-siGnwE >[oZYIBJuf;X_YoE55(_Jkǖ>ƢncG $<c{Pp6v+DRčs$pO~%]6Pm"--Bd8oI `z;_&$-SMkii5jPAncly j_x{.jd kXXij;;&p fVg^~_/M|K-_gZ5.0'oB9q^Ke8\W5x_PZ y]aY69fUAu7 L%%HQ+\種Dp.cI??½ Yr|Y4=B+Ɵ^Vy:um>:Jl$^;skU} _ge+l:GrȈ39t nO>Ydzӷ/Ă ZiᯗiU3`j'kڍ+JMv(ه%.Lo1bL A4Uɭ_AK$a*b9$]u 1EҠ$d5-y'_oq[jPhuܼolaweV"BC84ii3^0*$[#xBFo5 Ft {KPQzRS$uRח7c=:GL}^-RNȤSfaKdz?c<,e$]å|ou[uXAbw<%^k4I+qdY۟. ~xxᭅUb[<_\b ;*rPR@ HM;4շa@=M"Hx_4|B֮6m}gODػUbЃ%p+¾)G[ikCAm0g‹kY ipM/v>q VfpiLg1Q>%p?u 7.'7uؑ*/`&03@ D9ǽ|{jWΩ=Z-*\JMo26[UfؾdPٻƷ2G\\d\_%;L#"<Mzւ-G&Susieq-^OLۣiXB@"<-kX5{D`{kAv -m~4BK$,09RV|Ykb-Z|$$H,&CYp[Vn{~JR@@4 &TN9ޏ53k´iv%mle|k;ƚ1 X|@j -]f3*ԕ.ƭ|eS,cmY{) F9^)"ȯ&t?Kj[Gj-E=]/ 2.W;I%FeÔ?|u4fnix\Ll|AX(-]d$lG9jaҼ[O>}Em"΋!dPT9`p0?iǥi8?Nq_skSxwY,zMIBcp֯lTё"uVڏӅ:̆]NXb)b)6$$?)(̃Ln^'tx[PhP8'g1CS*@:}=z04fءҬ"Md) m$GBihv&/"cl팲G5-G?H/PWB I G$(A}=WG$(? ?A}=G?€; dE@H/R~zԵ#y0Q\3zc(> |Ǯ P=)s\X?_Q|4\$(zu o uHG?“ ?f"+z(ǚ ͨ'*XG`\ ˏW(z?€; њ | ?fך | _tfI` =N:S/~_ U(@~hq_Q| ?f\fH/Q  ~ (6W.5-WK|Uހ:)}*L! iG?“ ?f1( K yW@9RG>_j*S _uH:b/H/R~A|8#N JW͌L##g G$AA}=G?—~2 Ml}:}+߾ *#)/>j@dqdQ\ׯt~/[wqc>w cqm(J`,1=s^|puXX6з:[%¹;ՄA=sޗ0o'յd-3OIXeq-Ur@H |g7B5إEk@%+q&%b 3@Þt=UN5{;xtݨ[Ld %;2ɰi?] MK=F n仳-0\4\Wbi mʆE4}?H[;G-.gCw@Y@r2 w) DW}u$1.'3ތT\' CK#ikjFƪc[w oWí^J4I{3|HGS$k Nq_F\ܖ:|t;uxZE~iLz=3Ē,o?,FC~`({M3Fw{$5\3#G*0*]OexwDӅqw?ƨ wMjn-Fq&'Bflho-BJI,n2ʹ I g]Fq-[G׭VQeqt8U<(a>.!G LX*cX|l&4O%ů|\f x6c]mT$Y {Xk) ^p\GwrX28 ڲ>sRIk,DybzA:E!a،}E&q7w@isĺo4GN]rd&WCSa}_9ċ5)~&;T} "!0]PgռVԵ>;vmfv J6ܠmr xL|Y^6 ]f#r>RqҀ:!=J8=G@Rn&qp&T\Z7t-ɸiw  wXZ=cvKq$_(wU93PѴrX Nqr@1۠\.s@Ro&q?:MVGb%ŭC=FX(,p88ZU5m*]ӦC-RDY2G!xn{ׁM4K{^ FqrՓFK=_ᯉ<#iy4z[}`~er1 jm3+4M(9WEN vx{LeefXQbI$I$w"~t? D -_ILxt a9 1|'V#мV%;8OɕU[{S:Η,$1\bkJRIK-ۼWu[{ (w@A|. $Bӂc7}*]~u1]R)GI`>:x^XR'Ew h#,J"I}<_ 7rvokctA]Nïxr K 5"cIUIs N ,I_to sc \gbPM=EM :qyMvs)0kS*MG W #@t飴SU?v'_ Ȑ\!' =+GY)qi:J^ ~\*drnNރ'JkMk;=iZ>[>SnrĐyTMhhѴGQP}Rs#dY2XI |R⛿~toLqI~to;@/GCn .=. aV&8sXZƯxgWn}X{;Dچ% s)f'|=Xa8 ̻b FHބJWۚnkVEWRĠb0G`G ^[q bD"`FAԸ.@ @ǵs|O/|?[ /N8[8v2N9#zAzx PHԌ A?tmUu>VQ[hyN(|dH'Ėڒ{knk/Ȅ;«|2n9;Go hvkeCO+3ɗQ%$&ќ Wo .l5 LR!9,INYvcԚبC SK.88iǨ+xoHU(*FG~ uO<Ҵmsu,4dHVVW-mQkI/fWY^Dޭ1Bvd c%F <-ڛ[=(Lܐ$Xؖ9!06pK|@Vkم_WwɸTJ_ .t羐r29,>ǩ4PπZM~@ or+Ʋ /{ >mJJм-ockgfkX,ck?{IGVRۃ_k/࿙x/kl-WѮo2mH,vY^-\]-{¶!}#r0Z unN~s&&o~אͲM̥<Fy?lfcX/k|AVhoj)>yA7Edd,db[wln\|>]_Yi7o2% VD!:s@e<x/kOJNǂn)MyajwPr`ⵧG.[hZn}VڰY$nYv"(^Kg<x/j%"ȩ>2I8~?zŲ ?lfzP/[/࿙x/j%RŲ Ok/࿙~.|L𶙧jvn4o~+DܙC'* =x/@Ѭ_ׁj[`)cY_3^'O>&ӵZiOKnZKtq&Wh]s௏EuMm -qqcyTпض_3G-_ոW9Ͻ>(bE`_/xr$𬀔H XJA8 tGG:dO|⯋~8NImZhVwؐE2DN!|82FS-~#7w7ZM64KHs@-_g<5ze<4F3Wcΰ_ƌs~44cY|\YM:Dמ hGqMd%NU]ٸ]>|V-޴7k$nkI"x cvd&D| 04ض_3G-_c4Gx/hŲ EPƲ3G5_לz] -[F0Lk&L–%1'OkIzVxte[Z.,emCi &聢`x/id&W$:dx ?ض_3G- \/! Vk}*[00RG#$e<4 |_|.=f]?N濶ӊ;:;Plp_"#Cs䶒'{ġ$b˒)y+bضCX/js?L N$?im2{4,(_x/h5 ?"xU%&ҭ5o.t35+Uebx\O?V?X #[CpBۆh0ñx'o ~CAŲ C`.^41kVv7&Fi=@SX* d?fux?Ls\w?ȣ~{Pc?|'xJm;WUt(vD`C#+C)k~{Q}=( <-ccohLRA*üی˒]snv͓η<)x+FK`h,љW٘;3voG?ȠƊ㿷E";G]Gq"@~gU$Z֛jqRȱœA;Ne%{MKkҕ&dIG/~D}OG?Ƞh:G?ȠƳ =ޕG{Oo0He#Ѓ\? ?E;KQ" 9ߴwK,Ff.v\chƇ| ȴk1fS_1ߜ`N`"W}=?@oc|_@AweD{P;Mb&z徲@;'ǎ'=OW:oFʰyUebd6\(ΆKXmw%m*bp3Wj 5->[FF`8|GSA3apb[v1q >*^PQKE%Rֵ?ú|ڝq<PI 1Wξ4xOQEK#e/V "\(ei\jvj(Qs3c9xZk67 bŚ9ԁ9_}+_jWz՝{e_:k8VJӉIi,b8o>.b<1KKk!G273*c |}F?’^f;Q@׉t-5]8_]ck<$95VϭX]-'Svms^mOsyoFFeT-PRf QA*+ iHaKd WD_1ޘ?0[5jڵSwi: " pGҾiV=b̶#KwH-[hvP\8P OZ|J$ *CK (=hZJ)Ȑ;*FYu4W54ƍať5ˠYZ%02DUd*H`pƀDJXxMmY*jU,ǃcct5jv͌W71^ZK8d~ppGk_*5oeф?:`wp!*,^_|kk5/!D9Ÿ ψ'rrHcE(8R䯿b_@ҵ4kfUY:$=pqnqC%c{&um.P`AlzsҼuSĞ#Ik?^tIuql$2` | ErQH<&VoS/mF @}n]Pt)0B#IzjB ҐWH NSKD0I!qW?Z躖;u}֙37R5aA FNj3^#-d03m`}/LrH3@5cRXdp;?tC=oK[mcoͿld=j#t6MJo KoDag%aL|{ՂCgoW!Өx~}Y_&Im>˿{4- `8q_;z]Cmo"E:*P> ~&@{|/:5xzaDףvd=ߒI ; 9(:.k7? |[yeKmS× m![J3\rpE|5 ~&G.?=]}|2+6/an51ؤr[4l%,&ݸ6s5> xXмujwOn#q{yѳ6ŋ@-~GM.]{7.? ~&G.?=]~Q޿t|A8أA_> o\tC߉qqP҅`p=~:C߉qq ~&@Yh_]{7.??t|A8* ~&G.?=]~gҎt|A8ؠ1E~:C߉qq ~&@Tv_]{7.??t|A8+($W.?=]> o\tFqR ~&G.?=]~Q_> o\tC߉qqQt|A8ت+GM.]{7.?9=+GM.]{7.?t|A8ت;W.?=]> o\tFqO9~:C߉qq ~&@tW.?=]> o\tGZtGM.?b@N8?t|A8غ+GM.]{7.?~:C߉qq ~&@xzLg>5 ~&G.?=]~_> o\tC߉qq].?=]> o\tr9bt|A8ج~ ~&G.?=]~=1_> o\tC߉qqP_sJ+GM.]{7.?{.?=]> o\t)@{W.?=]> o\t'_> o\tC߉qqP;QzOs_> o\tC߉qqV0:+/@>$as( endstream endobj 153 0 obj << /Type /Annot /Subtype /Link /A 154 0 R /Border [0 0 0] /H /I /Rect [ 321.5775 67.7056 332.4195 77.6262 ] >> endobj 154 0 obj << /Type /Action >> endobj 155 0 obj << /Type /Annot /Subtype /Link /A 156 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 571.5952 260.2500 730.5952 ] >> endobj 156 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig9.jpg) >> endobj 157 0 obj << /Type /Annot /Subtype /Link /A 158 0 R /Border [0 0 0] /H /I /Rect [ 227.2755 463.3958 238.1175 473.3165 ] >> endobj 158 0 obj << /Type /Action /S /URI /URI (http://@references) >> endobj 159 0 obj << /Type /Annot /Subtype /Link /A 160 0 R /Border [0 0 0] /H /I /Rect [ 321.5775 67.7056 332.4195 77.6262 ] >> endobj 160 0 obj << /Type /Action >> endobj 161 0 obj << /Type /Annot /Subtype /Link /A 162 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 571.5952 260.2500 730.5952 ] >> endobj 162 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig9.jpg) >> endobj 163 0 obj << /Type /Annot /Subtype /Link /A 164 0 R /Border [0 0 0] /H /I /Rect [ 227.2755 463.3958 238.1175 473.3165 ] >> endobj 164 0 obj << /Type /Action /S /URI /URI (http://@references) >> endobj 165 0 obj << /Type /Annot /Subtype /Link /A 166 0 R /Border [0 0 0] /H /I /Rect [ 321.5775 67.7056 332.4195 77.6262 ] >> endobj 166 0 obj << /Type /Action >> endobj 167 0 obj << /Type /Page /Parent 3 0 R /Annots [ 169 0 R 172 0 R 174 0 R 177 0 R 180 0 R 182 0 R 184 0 R 186 0 R 188 0 R 190 0 R 192 0 R 194 0 R ] /Contents 168 0 R >> endobj 168 0 obj << /Length 12988 >> stream 0.271 0.267 0.267 rg q 15.000 -40.655 577.500 817.655 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(test has been performed.)] TJ ET BT 26.250 748.071 Td /F1 9.8 Tf [(Of 905 patient participants who responded to this item, 203 \(22%\) of participants with Duchenne and 7 \(1%\) of participants with )] TJ ET BT 26.250 736.167 Td /F1 9.8 Tf [(Becker participants report using a breathing device. Additionally, 592 \(65%\) of those with Duchenne and 59 \(7%\) Becker )] TJ ET BT 26.250 724.262 Td /F1 9.8 Tf [(participants report not using a device; 39 patients with an intermediate phenotype do not use a breathing devise. Among )] TJ ET BT 26.250 712.357 Td /F1 9.8 Tf [(devices used, 37% \(79\) use Cough Assist and 36% \(78\) use BiPAP. Figure 10 provides additional detail on use of breathing )] TJ ET BT 26.250 700.452 Td /F1 9.8 Tf [(devices.)] TJ ET 0.965 0.965 0.965 rg 26.250 512.917 555.000 177.655 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 690.572 m 581.250 690.572 l 581.250 689.822 l 26.250 689.822 l f 26.250 512.917 m 581.250 512.917 l 581.250 513.667 l 26.250 513.667 l f q 225.000 0 0 132.750 35.250 548.072 cm /I25 Do Q q 35.250 524.167 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 532.548 Td /F4 9.8 Tf [(Fig. 10: Use of breathing devices reported by participants.)] TJ ET Q BT 26.250 495.893 Td /F4 9.8 Tf [(Cardiac)] TJ ET BT 26.250 476.488 Td /F1 9.8 Tf [(Progressive cardiomyopathy is a major source of morbidity and mortality in DBMD, and there is disease in the myocardium well )] TJ ET BT 26.250 464.583 Td /F1 9.8 Tf [(before the onset of clinical symptoms \()] TJ ET 0.267 0.267 0.267 rg BT 192.605 464.583 Td /F1 9.8 Tf [([2])] TJ ET 0.271 0.267 0.267 rg BT 203.447 464.583 Td /F1 9.8 Tf [(\). Of 1565 respondents, 81% \(1265\) of participants report they do not have )] TJ ET BT 26.250 452.679 Td /F1 9.8 Tf [(cardiomyopathy; this includes 80% \(1100\) of those with Duchenne, 82% \(94\) of those with Becker, and 86% \(71\) of those with )] TJ ET BT 26.250 440.774 Td /F1 9.8 Tf [(an intermediate phenotype. Sixteen percent \(216\) of those with Duchenne, 15% \(17\) of those with Becker, and 10% \(8\) of those )] TJ ET BT 26.250 428.869 Td /F1 9.8 Tf [(with an intermediate phenotype report having cardiomyopathy. The remaining individuals reported not knowing whether they )] TJ ET BT 26.250 416.964 Td /F1 9.8 Tf [(had cardiomyopathy. Figure 11 shows information on age and diagnosis in those who report having cardiomyopathy.)] TJ ET 0.965 0.965 0.965 rg 26.250 209.179 555.000 197.905 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 407.083 m 581.250 407.083 l 581.250 406.333 l 26.250 406.333 l f 26.250 209.179 m 581.250 209.179 l 581.250 209.929 l 26.250 209.929 l f q 225.000 0 0 153.000 35.250 244.333 cm /I26 Do Q q 35.250 220.429 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 228.810 Td /F4 9.8 Tf [(Fig. 11: Participants reporting a diagnosis of cardiomyopathy, grouped by ages and diagnosis.)] TJ ET Q BT 26.250 192.155 Td /F1 9.8 Tf [(Of 1581 patient respondents, 1,005 \(60%\) report not taking any cardiac medications. Seven percent \(122\) take CoEnzyme Q10, )] TJ ET BT 26.250 180.250 Td /F1 9.8 Tf [(8% \(140\) take Lisinopril, and 6% \(110\) take Enalapril. Use of other cardiac medications is reported among less than 5% of )] TJ ET BT 26.250 168.345 Td /F1 9.8 Tf [(participants.)] TJ ET BT 26.250 148.941 Td /F4 9.8 Tf [(Supportive Therapies)] TJ ET BT 26.250 129.536 Td /F1 9.8 Tf [(The DuchenneConnect registry collects data regarding participants use of many supportive therapies, including health )] TJ ET BT 26.250 117.631 Td /F1 9.8 Tf [(therapies, rehabilitative therapies, vitamins/supplements/other medications, and alternative/naturopathic therapies. Physical and )] TJ ET BT 26.250 105.726 Td /F1 9.8 Tf [(occupational therapies are among those most frequently used by participants \(34% and 17%, respectively\). See figure 12.)] TJ ET 0.965 0.965 0.965 rg 26.250 -40.655 555.000 136.500 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 95.845 m 581.250 95.845 l 581.250 95.095 l 26.250 95.095 l f q 225.000 0 0 120.750 35.250 -34.655 cm /I27 Do Q q 35.250 -40.655 537.000 0.000 re W n Q Q q 15.000 -40.655 577.500 817.655 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(test has been performed.)] TJ ET BT 26.250 748.071 Td /F1 9.8 Tf [(Of 905 patient participants who responded to this item, 203 \(22%\) of participants with Duchenne and 7 \(1%\) of participants with )] TJ ET BT 26.250 736.167 Td /F1 9.8 Tf [(Becker participants report using a breathing device. Additionally, 592 \(65%\) of those with Duchenne and 59 \(7%\) Becker )] TJ ET BT 26.250 724.262 Td /F1 9.8 Tf [(participants report not using a device; 39 patients with an intermediate phenotype do not use a breathing devise. Among )] TJ ET BT 26.250 712.357 Td /F1 9.8 Tf [(devices used, 37% \(79\) use Cough Assist and 36% \(78\) use BiPAP. Figure 10 provides additional detail on use of breathing )] TJ ET BT 26.250 700.452 Td /F1 9.8 Tf [(devices.)] TJ ET 0.965 0.965 0.965 rg 26.250 512.917 555.000 177.655 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 690.572 m 581.250 690.572 l 581.250 689.822 l 26.250 689.822 l f 26.250 512.917 m 581.250 512.917 l 581.250 513.667 l 26.250 513.667 l f q 225.000 0 0 132.750 35.250 548.072 cm /I25 Do Q q 35.250 524.167 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 532.548 Td /F4 9.8 Tf [(Fig. 10: Use of breathing devices reported by participants.)] TJ ET Q BT 26.250 495.893 Td /F4 9.8 Tf [(Cardiac)] TJ ET BT 26.250 476.488 Td /F1 9.8 Tf [(Progressive cardiomyopathy is a major source of morbidity and mortality in DBMD, and there is disease in the myocardium well )] TJ ET BT 26.250 464.583 Td /F1 9.8 Tf [(before the onset of clinical symptoms \()] TJ ET 0.267 0.267 0.267 rg BT 192.605 464.583 Td /F1 9.8 Tf [([2])] TJ ET 0.271 0.267 0.267 rg BT 203.447 464.583 Td /F1 9.8 Tf [(\). Of 1565 respondents, 81% \(1265\) of participants report they do not have )] TJ ET BT 26.250 452.679 Td /F1 9.8 Tf [(cardiomyopathy; this includes 80% \(1100\) of those with Duchenne, 82% \(94\) of those with Becker, and 86% \(71\) of those with )] TJ ET BT 26.250 440.774 Td /F1 9.8 Tf [(an intermediate phenotype. Sixteen percent \(216\) of those with Duchenne, 15% \(17\) of those with Becker, and 10% \(8\) of those )] TJ ET BT 26.250 428.869 Td /F1 9.8 Tf [(with an intermediate phenotype report having cardiomyopathy. The remaining individuals reported not knowing whether they )] TJ ET BT 26.250 416.964 Td /F1 9.8 Tf [(had cardiomyopathy. Figure 11 shows information on age and diagnosis in those who report having cardiomyopathy.)] TJ ET 0.965 0.965 0.965 rg 26.250 209.179 555.000 197.905 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 407.083 m 581.250 407.083 l 581.250 406.333 l 26.250 406.333 l f 26.250 209.179 m 581.250 209.179 l 581.250 209.929 l 26.250 209.929 l f q 225.000 0 0 153.000 35.250 244.333 cm /I26 Do Q q 35.250 220.429 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 228.810 Td /F4 9.8 Tf [(Fig. 11: Participants reporting a diagnosis of cardiomyopathy, grouped by ages and diagnosis.)] TJ ET Q BT 26.250 192.155 Td /F1 9.8 Tf [(Of 1581 patient respondents, 1,005 \(60%\) report not taking any cardiac medications. Seven percent \(122\) take CoEnzyme Q10, )] TJ ET BT 26.250 180.250 Td /F1 9.8 Tf [(8% \(140\) take Lisinopril, and 6% \(110\) take Enalapril. Use of other cardiac medications is reported among less than 5% of )] TJ ET BT 26.250 168.345 Td /F1 9.8 Tf [(participants.)] TJ ET BT 26.250 148.941 Td /F4 9.8 Tf [(Supportive Therapies)] TJ ET BT 26.250 129.536 Td /F1 9.8 Tf [(The DuchenneConnect registry collects data regarding participants use of many supportive therapies, including health )] TJ ET BT 26.250 117.631 Td /F1 9.8 Tf [(therapies, rehabilitative therapies, vitamins/supplements/other medications, and alternative/naturopathic therapies. Physical and )] TJ ET BT 26.250 105.726 Td /F1 9.8 Tf [(occupational therapies are among those most frequently used by participants \(34% and 17%, respectively\). See figure 12.)] TJ ET 0.965 0.965 0.965 rg 26.250 -40.655 555.000 136.500 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 95.845 m 581.250 95.845 l 581.250 95.095 l 26.250 95.095 l f q 225.000 0 0 120.750 35.250 -34.655 cm /I27 Do Q q 35.250 -40.655 537.000 0.000 re W n Q Q q 15.000 -40.655 577.500 817.655 re W n 0.271 0.267 0.267 rg BT 26.250 767.476 Td /F1 9.8 Tf [(test has been performed.)] TJ ET BT 26.250 748.071 Td /F1 9.8 Tf [(Of 905 patient participants who responded to this item, 203 \(22%\) of participants with Duchenne and 7 \(1%\) of participants with )] TJ ET BT 26.250 736.167 Td /F1 9.8 Tf [(Becker participants report using a breathing device. Additionally, 592 \(65%\) of those with Duchenne and 59 \(7%\) Becker )] TJ ET BT 26.250 724.262 Td /F1 9.8 Tf [(participants report not using a device; 39 patients with an intermediate phenotype do not use a breathing devise. Among )] TJ ET BT 26.250 712.357 Td /F1 9.8 Tf [(devices used, 37% \(79\) use Cough Assist and 36% \(78\) use BiPAP. Figure 10 provides additional detail on use of breathing )] TJ ET BT 26.250 700.452 Td /F1 9.8 Tf [(devices.)] TJ ET 0.965 0.965 0.965 rg 26.250 512.917 555.000 177.655 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 690.572 m 581.250 690.572 l 581.250 689.822 l 26.250 689.822 l f 26.250 512.917 m 581.250 512.917 l 581.250 513.667 l 26.250 513.667 l f q 225.000 0 0 132.750 35.250 548.072 cm /I25 Do Q q 35.250 524.167 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 532.548 Td /F4 9.8 Tf [(Fig. 10: Use of breathing devices reported by participants.)] TJ ET Q BT 26.250 495.893 Td /F4 9.8 Tf [(Cardiac)] TJ ET BT 26.250 476.488 Td /F1 9.8 Tf [(Progressive cardiomyopathy is a major source of morbidity and mortality in DBMD, and there is disease in the myocardium well )] TJ ET BT 26.250 464.583 Td /F1 9.8 Tf [(before the onset of clinical symptoms \()] TJ ET 0.267 0.267 0.267 rg BT 192.605 464.583 Td /F1 9.8 Tf [([2])] TJ ET 0.271 0.267 0.267 rg BT 203.447 464.583 Td /F1 9.8 Tf [(\). Of 1565 respondents, 81% \(1265\) of participants report they do not have )] TJ ET BT 26.250 452.679 Td /F1 9.8 Tf [(cardiomyopathy; this includes 80% \(1100\) of those with Duchenne, 82% \(94\) of those with Becker, and 86% \(71\) of those with )] TJ ET BT 26.250 440.774 Td /F1 9.8 Tf [(an intermediate phenotype. Sixteen percent \(216\) of those with Duchenne, 15% \(17\) of those with Becker, and 10% \(8\) of those )] TJ ET BT 26.250 428.869 Td /F1 9.8 Tf [(with an intermediate phenotype report having cardiomyopathy. The remaining individuals reported not knowing whether they )] TJ ET BT 26.250 416.964 Td /F1 9.8 Tf [(had cardiomyopathy. Figure 11 shows information on age and diagnosis in those who report having cardiomyopathy.)] TJ ET 0.965 0.965 0.965 rg 26.250 209.179 555.000 197.905 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 407.083 m 581.250 407.083 l 581.250 406.333 l 26.250 406.333 l f 26.250 209.179 m 581.250 209.179 l 581.250 209.929 l 26.250 209.929 l f q 225.000 0 0 153.000 35.250 244.333 cm /I26 Do Q q 35.250 220.429 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 228.810 Td /F4 9.8 Tf [(Fig. 11: Participants reporting a diagnosis of cardiomyopathy, grouped by ages and diagnosis.)] TJ ET Q BT 26.250 192.155 Td /F1 9.8 Tf [(Of 1581 patient respondents, 1,005 \(60%\) report not taking any cardiac medications. Seven percent \(122\) take CoEnzyme Q10, )] TJ ET BT 26.250 180.250 Td /F1 9.8 Tf [(8% \(140\) take Lisinopril, and 6% \(110\) take Enalapril. Use of other cardiac medications is reported among less than 5% of )] TJ ET BT 26.250 168.345 Td /F1 9.8 Tf [(participants.)] TJ ET BT 26.250 148.941 Td /F4 9.8 Tf [(Supportive Therapies)] TJ ET BT 26.250 129.536 Td /F1 9.8 Tf [(The DuchenneConnect registry collects data regarding participants use of many supportive therapies, including health )] TJ ET BT 26.250 117.631 Td /F1 9.8 Tf [(therapies, rehabilitative therapies, vitamins/supplements/other medications, and alternative/naturopathic therapies. Physical and )] TJ ET BT 26.250 105.726 Td /F1 9.8 Tf [(occupational therapies are among those most frequently used by participants \(34% and 17%, respectively\). See figure 12.)] TJ ET 0.965 0.965 0.965 rg 26.250 -40.655 555.000 136.500 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 95.845 m 581.250 95.845 l 581.250 95.095 l 26.250 95.095 l f q 225.000 0 0 120.750 35.250 -34.655 cm /I27 Do Q q 35.250 -40.655 537.000 0.000 re W n Q Q q 225.000 0 0 132.750 35.250 548.072 cm /I25 Do Q q 225.000 0 0 153.000 35.250 244.333 cm /I26 Do Q q 225.000 0 0 120.750 35.250 -34.655 cm /I27 Do Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(7)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Muscular Dystrophy)] TJ ET Q endstream endobj 169 0 obj << /Type /Annot /Subtype /Link /A 170 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 548.0715 260.2500 680.8215 ] >> endobj 170 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig10.jpg) >> endobj 171 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 177 /ColorSpace /DeviceRGB /Filter /DCTDecode /BitsPerComponent 8 /Length 9710>> stream JFIF;CREATOR: gd-jpeg v1.0 (using IJG JPEG v62), quality = 90 C     C   ," }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?R1@b(? ? 1F(bŠCr⧄1k]!M}_cCtQP.Jҫjz型]:664725P$03Ҁ/\ޏAAuiڌWù}LymT=yբh4O$H0R30H"7~ׁ=k!KxbOdX[G}B!t:[vJc$]EAcY74z<0 qxb33@T( RiZh$u45h2ok eEeAlf>*!xYu85u3oZ@-oe{5;|c+PѨ@A*y'2joJngIR.O!cui%?jm  5eךe#α#0F*̸s#>|7o~0Pުp/{ Fϒg*34f> FI]:7躤-|ЕEnRF#"៍4-[iyuUd`ןdI<~4>? 7:}W6~!/'{g-bmK3c-vZ|)kɣxRr[_y{?2gy9K6Wjg}0k(fMí;TFP#7$o,pI玜צQEQEQEQEQEPEP( )i(bƌ1GG@h(PE-%ZJ3EQKI@Q@RnhaIR);dTpJBJ8(&Df`q9idX̊$`JnHp?@K3P2I8RyɄ;N~~? }f(((jziz}ܑ*Bv46;*%fGEk7kk3Gm&K%۾ip=vl/.w-ݽ]ۧ\m XnYAQIHmt]Oᇈ-4HQ%Hźa.Nˀ2J) *'5Gï[kFlFoiƖ @6wfKb9#bF]_\xmB 9i kμAK=Y81XmkHҜSF&~$4ވB)*0"7G}`K9+&byNhD8;GB8}GWN5 z8sj^]pjp%6a֕phӕY+eV sNRv]]']YX__Ku$?Ba#n\ >qd '+*@sϵ|'_7rSIQ!٫nizŤzF6@<޼K7a]ϠpUJ%Z-xWVP>f\I]Fj^!fW@⾒YV.*>~9s^@~ΉzmL,Wo|\#Ěm7HN\3֧ͻ4g8}h(C^ "hM-eZeKEYcc[ On}=Q0ڵYSMG3}4xH}i{:ַ! 4NωYx_#bjb(Km{[E;Gn\;ȷ ;s r~dJ῁[]?]xRmUdO8'D`BKf}Q_i֦Jh}]Yni%$lɶNG-oSPo*M#r=0hPK 6r_~9{^$ҴJa)H]XX=(PJZ(83U5{y˘m^wBs+g`Aǡy=Zj}y'{-% &⏉tF'7R` cd^e>`[G@T.8LhaiVB>7 h@7!m#mFXm] "y Bq# ־+cQ:-.&'{Hީϗh``Vq~ |S_Mecv";*]HZ)Q_capd꽭ZCQHPO@Š()i)h()H)9֓{d<)e.Kl5C裟’WEk^>l3?9X Vֽ =L 6e}B}Q}(Ҧ?KjLqn#>[U s?J1ȯNt4U9jKSA&=IҪo XWǵ?j~aYxN#]܊88> R? D^YC*>@REg'sȫG߻PCss?M7ng[)ڄXGgiAz̊`df;<AL],2ۂuEƘٶ=alg'k%Gt-=Ÿ{+Ɯ9>F4$%f~muWRFE?_E׋~zc2h`.i%7՟oJQPcyῺpV}ec}=V\MhUy? d5/Gn.4i:ZϨ]s4K2y`ed*d#39+Wkw% bpWg /z^] ߵ~~|p'֝R^2߄_ѽ^ٮ Qunr,-۳ +\{;;m|KD*HʞOJe{l#э|DZќ=MU}n[0eSCamQ[CDsu8:+*o?~%ٞ.-eۅg*uGgFMs;&ެ^*~%%>rhЬ.hI6{ TZsj62QϰYyΛZUN?Ak&gemr3A5 EfSZC,r5m * 0w܎⺇-tۖ>΂!$8 : Xp"h?^K*:ZLo,;Z9ǩ;C :v][\1^xU@n$El(z}v­u?)ӯgҞ v;x"QZth3+[`׈xWWDŽ&_h0\M[]\m$8 b5jri=Ƥֈ>uk}+Hk0yK8[͝4\(|A$Ӽ=sfmo97gb(uB/8ْ} '\wЏS{U}X%(n-mBi+n?5c|4Joƭq-mw62w.RK0><{l g84 |g(ŇK{ȵ1R R_h[= s_i7EylڌږaXp#[@$T-#t58;wzP9PG^AɥGޡC@ KIEQE3@Rմ[-v{+h'RC*Vi=[e<>'Jl9?| Ԥ46 :d5c^xGFe4mF؃ }xX]i}zu2m '?~^.}"]?^'  1|/=^0tY3oo7L7MiY!/%LWH䱱Ѭٴ6xƌ5/Lr m?t"LqJ"@1cҲx>1jolbnՋZLKkKxYHFYI_6k_/;خk>-->`F ~k$2v/|Y'-rg{M[k&av(t17v)wNT؏ju}*+x. Ey $OC^S<1;N{ {v-lٶ$$F!P Uv<hZ4]G\_ IJ0F16TB lcmu1~.cEA,v0}*}ɥТMrUJERoc21gc8>.5/iVsYA&n%[3~*|Ag}sv,Y]#+GO.Jn,mebC# €I8bXmo%m.YnFGZ;J|i-GCx}φ7> endobj 173 0 obj << /Type /Action >> endobj 174 0 obj << /Type /Annot /Subtype /Link /A 175 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 244.3335 260.2500 397.3335 ] >> endobj 175 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig11.jpg) >> endobj 176 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 204 /ColorSpace /DeviceRGB /Filter /DCTDecode /BitsPerComponent 8 /Length 15737>> stream JFIF;CREATOR: gd-jpeg v1.0 (using IJG JPEG v62), quality = 90 C     C   ," }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?QE.(/Z(LfZ;SX{W˚_~6x?<+mx'ȋUG}CIܐxquo۪oM[_]~Ojz H`Em$Er@S8Ko|5o5/w^)<;*[ZȀT0q I`?:NojڱɶC\Hl'Vಌ*b8oRZBZV>4kwd,?i02p0=4,x+PMbXCҭ5{ic\tRCP sܟ |)moUZ[r&Ts"#F,>a_ ^⛛ o^hN5Y-̒>'~߾}KźOPӵ}E,dFR|+3as@X_k_l>[6:ݭZ}k$IIp(+l<5 pj_`vS^mEx֯ dy;=֊O/< ᫓nNI! ۙZ,0;K*Z/]񍇇mqwK%Tfgi;m$Og(xV|8`杭ϭOpm"G Є#'{_/>O}֙M:SOGi1¬T y)O.^ ݬmm\Zl#$>zQL3l4zSὯI< mbG ^P4x+Q\3N>q}S(soSLP, S42:(0X2:W#~ƾ ^rxIBIvg{ xgxu~!|BX_i!`8^5]xuboWё-*Q}FzPȞG¯iZ.ik:u ق4|Z%o_|Uy-cN$ikAlR(lr0kڎ xwMRe0Ea{m]AKc| {(ZJZJ(t(zغb&&T\nOA5nwǿ|]ygiasɦ]#Lm1hg;N]J.la4Fψt c7in_;ck~4o |nnY9 "g%# R5庸ۋ2KЅy,x tMtMtaOOstMtMt{OOstM',M?]&F@,M?G,M?]&h}h@ߧh@ߧk}hOs@,]?P|QŠ~ 2#1]N_ @M&O K7 v Oyl4ɬcy0w+8qڱ<-jtXgmEݻ$GQO=A퉴ȄҶX;31$rI$g8'EE@>,z6뤿M.|Y9z|Y<7F|Y<&?7Pm5Im5I? ??7Pm5Im5IC ҡk!suگ?c*Vۨp4IXvC>.E}oE/Du/a =N+U]+V+[ܩ%]?}apVvMzYKſs8w7_Mk{+ ˜8AJu+j*k{ϳm~MsQ8lO >?Osu'ߤi,]Q$<~I6 WVUmuj˶/G[2^7 Yf8b^۸}xsu4P|j/VO><'?7Pm5Im5IFd G\]A ]'Q ]'Pho mxMsu&#YtG&#Yt@ .o.G3ds]C ]'RH:N F4 :)٦w <L*IՎ|S6r W|H<5XgMC$P6B&dn 3h~i /A,>{o}ᴸh~ٵ[p,f%gH,Noٳ}Bѽ(>KK!`dl @' Aš|+S^w^]P"%@OA &KQZ#Q"czz_\[5io䰖'* pabmoZ׾«[h %-a'J==:FPk@ms>%k@Ѵ{=_-](/ .kŪu@5>|#P)|U/45S&l-eʍ?2-5߭vRRd4E7^}[ȯnzq_%>)BOW~d;W^#F> W˻w]障fAb?FvzO njl?>%&mUft!(Ϋ3/Gi|.o_Z襮h~~!ohhT>g5d_Nh=:翲|KC e>%趏Γo{'Ŀ0ZQ_-](=:6ιkGW`wlh6}k/ . 'ęgvΖNOsC99Ҝu73N#" (FhfU=^;-*Y(yw>í\ȡeaHuq_w>5I5mY21""ᜨY+K h7\i$ۣH6#$`|<}z;MwM{#‘+@cQ 0rAǧ[W#/y:L/%co(eM.;[+hm-cH`@`Vxm|FH'Yꢬ߆ZoSuMKmfa+Ca-1v*kkj5@ncXy"? zw?vGk4x#cNHB|?@M;# Գ?CY>k?NHš \bi PZ(ɻ/h@?k/׋~:]> Mx[{tI4 G~ö~'\=^kmm[WD<'h,3گig3x'g+ԭ:Pme bIㆢH. W(vWMOV[YHajW_vgl"%!'8΋z3WOf~}hc/_%09??ؚwO+o֩^X h%lޖ3xz?ퟡv_ ߗ\xŢ%QJ08'ӿ?𯈿o-.J]VVZK1UVBҭAAް~8gO :ͥ:NGnn6.Ny,=OS|;įX;jj/$⼏|-N@m~2tU%G Fa Ufzg" ݬ4u5Z [=+,_7Ğu/MwYLukdv8"'ӿ?'*qo{qN 6g?p??Ƴ 4('ӿ?&8;?/jYgi Rx| bi PhԳ?y|}ѴP I'jg޻$MN $JOcpG 'J#P: ♓>}NI>$WN: X[pr8Mž%Iwqw'ZHpSOYwdkjg^TQNZ_aܚǪ2@#;i?;{!1?um=Sy0I&i,nB6qΑ1RQ_cWO *W#Sdy;~c)W秉@ȱ fAb>RWVz(5 Y<}Ɯ,w-b7?#c O q!'oF Gԟ |GE%U-t{l/#3^MfkzXѯdIr?+qH?{¿ K^;p' VyzKJ_3?bjqCߠo~E?{% qP98֔?Dq_wG][Z?(UտJ?`~Vsj?*R7"[Udlր?9m n*^K5R KoL_,G_xxQ6<1F%:o_ Xo[_WEۓk$Pd'M)┐:נ|> x@}sRa[[O JeYB V>Aޕ 64JOL"sF营FeO"NPE!i^\8~uy:+1h+?We+3Zmnm{icY"`\" (Up;1ti5zoƨjMOTX L/^ɩj7{IjOi2ZFC3NZP`s5|'ӦxᧆkUl[(.m*2@je7;*a*ҡ D-CѮ, kˬ_^L! zv\'jkŪXלѠC][W)X궗w ,E U_?F?EjVr>̩4Ifk|e_?D}'F>!ԤRU Ugcc-ƻ⾞V2[$.>e#O MR4,]P$5weXh !9U^g +2bG/ǩ|Kg!,mOI_<Ͻ_y~!?/~#լoe~.6C𿟼l۸sfC?g^ɩj#,%]K}=%&G6} !ko۷[We57..*>O^?ï 8lB*3kɿl&m˫^_/C˸@Zo>ݿÿ E&b&l:r+lhXl5;[ɆP kwɔҗ?b}rŬ^)կT~y k~*ږw#Լ{ 2!;O9?^WDikp5[bPzWxvwm֬M:eTIԖ;O?/O ƭx|AGVv, lt__/HS-|i LмgfoY,l.~y־<.2?atSfc Ƭb5{C&|[F2jſX>M#ԾmWW_n]{Z QVHp>閟 ?dO c\W*r^9yL Kg6 \sއV R Rk|G)4:ѨG:?~aלWʥ1>kq2:!rlk&\nAoqsإ(P.4ՓwIlx:&v1#Lx_VRASp>`9=?˴c-VY*nmZ-3~O{A\DԼ9eX1k\;) H{;U//+}GQ(B# '^릻0GN>$}⑻:__-G-)x/cfmgH@cWtJ1ϭ|ozΝc5`JWv6Ϯ;΄UG"T[]<Ό_q.q"/ _K/WpH!KxK*Tt U5/|)4 >Ě1j?12y)ѵ~8,tb[Dw=]Pڵ}*K-lcZZQ}ܳ x9/zaGM/ Ƶ[:GA|+!9vɯ|~֚=+wi.B2X)X:={^UR];3E:!8~./eˋ}.= zPwKF3'{|+?<?i__c ƭ*208ök}#wcN%֮`'Ï6 i_YO{o~Yp\U"ۻG6;Ж]T Wα70D t`}}O Zua?lRWa&ކC*RFz ֵ:[96eHK.A=T5=iF)sL&5lr><(((JL})h)(qT5ĚTvnVs&$dH#A9*CEЬt 5,l [+3m,X3ffbK1bI$I$ӖGlGm3\L\,ĞҮH_Ż:4KN[h_ݘI2d$*(%#=WD״ipEa6|ID  8? |m7f n<+9\_/Mj^0U(7%${B>P*(~']|)t^=)uKX/G"x(tyw,ŰHI^꺦j6wcWBۚ`JGjкӭ䷖hI-lG? wxM :X[O΄eVYyUƅk6%ii\Cm4]U瞻5Vf\DnbSq!$3ӃNP1-ct=H-|1t?Akݗm"bIl^BM2apr^V;+iuZMi)gX #$ESNmAo,'j&.r958!,zKj[XMhGӇQ-w` Hci +-KTDZe $!Tp2I h 4$:vli$$1$&k !4/.|Wz855Zdh\Q:jRJ'}#`QC WSp5K nxYm–cܫX,vcoB0ʪI݂:xH$7:m3L_T0<\/uk.{ S6w1F!rYFT?2|:Vr&F&r4XEج71'=~k inṖ0g]csCcwTa^sY?m& \R"pL<] 4oi^kaI5LYVv ʶ;1^wFZXHԼ9uhfhG][:ĠcfQ0F%rS IKk-e+L/ &і:gtz׋4XZZơ ;B8W=NHRR+5'\%/.mf[tDh7HfH bYE ʰ=6Kh4>c TԒTԒ*jvW ȳUԝ!OA^;/vke}!-I;.t|aa6]x-gt{4̮c@a 6U %YO暺u}i1y>o}?:ρ:u5~A^XIml [>@;R⒖ihERR($EJ(+?Stb{Il-o&ζvH;O (@S&J dϡԔP`z ό?ߋWqPddhuvG9*A b`9'>|;[^6pZUYt_2p%'ዩ*~^x>M( bx+E<5geoz~cG^N'suOÓO2Yéu4`4rG`TWND]TPYy7YQ)QU1]W[]RlfAv`]Y4@'jW-$r8yxV-k]3L}>?]\|_:0=kNXbfK{vFe1#'UcGN{[)- dΥn0,Tn('+uK{VuNAÕ?{w/gf53]l̚ Q? A!KXo />Q<*Cq8&'>߉tK{,/pوJxYaC}׶v@u^r׍y!N\1G-īQ2{xzT:=׋-%&$JH(rz׺~mVo{{Wď bٻug%Osב>OqsmirfuE @䞧5G.(%-b(JR3F)3Kހ QOJb(@QI\QJ  endstream endobj 177 0 obj << /Type /Annot /Subtype /Link /A 178 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 -34.6545 260.2500 86.0955 ] >> endobj 178 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig12.jpg) >> endobj 179 0 obj << /Type /XObject /Subtype /Image /Width 300 /Height 161 /ColorSpace /DeviceRGB /Filter /DCTDecode /BitsPerComponent 8 /Length 9311>> stream JFIF;CREATOR: gd-jpeg v1.0 (using IJG JPEG v62), quality = 90 C     C   ," }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?R(((P(@(iU?N+~ͮYOp-\$-ԗ̙eˑPGB S25֏ϏPpH/3%VRՎm\g 7G gnHmZ^"ˆaYM0*oP ##H+{"̌2T0H%SU/NsxNV7:d #+n3M#Kuan?A_j7%MMbm r0$!D  ׆dXP%Cс| |IWJ/gjriiM3-$wZ@+Lv|w|QZ^fk7WOov%cv,. yXrp)b׏E{*E9$76&2@ hbkK[+4y=:vEiYC|m'<@SX s'#w5O<]wmM6DŽm.52!<_Fy (?+ :y+Ki%*ml6VPߴ?@JX|+~u_571!TI?#S|C z4(ƶJ\pGܫ$$n'Ls@4Q@Q@Q@Q@Q@((Q@(=((4Q@蠐(4$2GL=3C-癚D MX&inRƠ@O4JCY_Y|&Iɥ̊sj+<J4Qg|9{95|=4v++?h4s sj50 K(+?h|9{95| yKeQgMY|&d}S dqO J,G%?ɣcb4Qg|9{96(J,ɣ?̃ϱEcQg|?(M=V?%?ɣ?̃ϱIXY}Rkr\#4s thӢQ@Q@Q@(EQ\OM jV$+IS{cWv+?kUt:/,⾷wk))zn܃jp:V+7L hnJTȟzw)kGmgy.mK7=0|rK^rG>l?>|0Rj3j^sxmiy28{e|6|RQpu)ON[r!609qu9m0fW||/ϋZׇ'h$X!Ӛk-#FG9&*9丬=9Uk#z+G&Mnխpe TN2AMlޙtve8 WNfQE-h(PQE 5Z~?CWS>0\W܋mN[QsވkF7BZ0+@$(r3Lc=4kkqy,n 0$#a> 99qmuoM;iu0A6]2s^s>PV? uiz5=:UT3 A$Lk( c9ET<CK-FIn'쇉ub>\`0H5 Vſڼ?kYGtFeD (SpXs֮|5gWu^->(Y,e.KT͹|fI鞦(3{[[Ym w$z#_qnĉy_´u?p^%y/a{geYK6rAOZ@p@j϶^&:ſ5ջymZIK:l!!TgMzߎ㿛\Lsֹ_ cz>A)xźrZU.;s; ږM}c.k[j.'Db8's'#&URo&{*J1h>c@g?,{ 0յxfKV\ơS+?ax[M'/ F9sGsT*GqSm2K^w ĉ"yWKA :koᯇNcq%ſ.@Tdx3Ԛ ¿1?G, ɤtUu#3Vt4w{d:?*X^IU?  GGR OGQu=OgCEs-C&T GGQu=OgAGzax[M'o4{*ΆaxWM'o4{*Ά`[M#o4{*Ά;!x~X^2 Uuԯ-ngE%&ãPG 9+V̬w :E;ΧQ֊`9x~VB$HT:Ȩ f ($|}1ޥ֌b$W> : 5ziZ-+q&7#S2W;⟅>mm}dH2HvFdh2Ƀ㧅|kǚ/.F,!32*nX2rEOqoHV'PpG$MD)>&&^: x>[[H_M FP+یU/'4mlzLQjeϴv`qqď}7 v/Sn\Zȋ `.qFy+K 3[i)KtrynyNzUA),M42Ffvx 黎Ծ xGX0^DDjrwd#c  wmA" 6)JGv:nfh94bXϬ_} ?UZV_Sg}?bXϬ_ؚ|?ZQ ?USOGؖG&>53T=>j'G0o7&>4aϬ_} ?UZQ:?| Ϭ_ؚ|?ZQ ?US`7%|Ϭ_} ?UZQ:?| a>4aϬ_} ?UZQ:O| Ϭ_ؖ_|=>j'G3T}N}?biG&>53T=>j'G0o7|Ϭ_} ?UϟP?k Z5.~{Uy,vѣ$dیK/O1a[ow:|.|R3Mp:m (9*!7s^>u[E[hTDcc v%~>_:j1G|hnqykcX]2tUIHϛ%bB*Pt eC"2oj=k> ֊(`O&yc0?ԿCi]PS&$(7^emBҮ"] s5˩U I`keV; \㜊2+MbtSrT\E}zё^uidTy|ʰveR%vy} RK%Wn6}qB|?f߁1v-'qN%QL?'=~(?${ vJ F"'qj}:q6qf $s⯅Wc曮ZOm,qH$.Ln1ukRO`|@\xVmS,<1xxZ`@#i{) w3$$llO&4'5xkxqԜl~L)-u?Hs(Ksosrί##>?*bR\9q l-9U/^qkѢwo+)Rxws+>;ڼIQAtfSA:3/tsF1ENsE-%QEQEQAE` 5Z~?CUwS{}u#.Of9{e~VS n6yYAy'<{oBS.(s䮦Mh p֍.ҳ(C |n𝷈/{U5 ڟn}+ ߤN_o?'y/TRc?O(ݩ0 ?@ OWҿG?% ? ~K}R`Xq5 >&]ZTmc1ڽHr3ҽHY7ֶz9ycFb}v,}TpЃZURiy(īGk}";NR7 xʎ*ޅxe&],%Ap9' =88 wȡD*U X|8nWnc+~CBG,-p~7:gk#QK#YIKu E2Nuw.If"[?Y>~[*toKJR-RXp095zm5ˋDIPGD?dOoOߖ  s)<lP3ԁ)9%y/Q(G,- ߤN_HGD?Y>~[+GHG3~A;fX '|??V3~A;f#3d[WM?xV`igX.K*ceKjwm{W bv%tT> ;N4lڝIK[BQE ( QEQEQEf;Q@(6z6Z(EG- !6z_m0X\&yGguGPfRXchR )׭сր>[3}D^{P=p#3|Ϙ=j OFݢhVA[ʛ&=ά?sv(P@Y9|/` Ow ^ihjn->v=Y;gGzRs)Xes/hFђp2} #+WIcሬ> endobj 181 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig10.jpg) >> endobj 182 0 obj << /Type /Annot /Subtype /Link /A 183 0 R /Border [0 0 0] /H /I /Rect [ 192.6045 463.6816 203.4465 473.6022 ] >> endobj 183 0 obj << /Type /Action >> endobj 184 0 obj << /Type /Annot /Subtype /Link /A 185 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 244.3335 260.2500 397.3335 ] >> endobj 185 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig11.jpg) >> endobj 186 0 obj << /Type /Annot /Subtype /Link /A 187 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 -34.6545 260.2500 86.0955 ] >> endobj 187 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig12.jpg) >> endobj 188 0 obj << /Type /Annot /Subtype /Link /A 189 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 548.0715 260.2500 680.8215 ] >> endobj 189 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig10.jpg) >> endobj 190 0 obj << /Type /Annot /Subtype /Link /A 191 0 R /Border [0 0 0] /H /I /Rect [ 192.6045 463.6816 203.4465 473.6022 ] >> endobj 191 0 obj << /Type /Action >> endobj 192 0 obj << /Type /Annot /Subtype /Link /A 193 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 244.3335 260.2500 397.3335 ] >> endobj 193 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig11.jpg) >> endobj 194 0 obj << /Type /Annot /Subtype /Link /A 195 0 R /Border [0 0 0] /H /I /Rect [ 35.2500 -34.6545 260.2500 86.0955 ] >> endobj 195 0 obj << /Type /Action /S /URI /URI (http://currents.plos.org/md/files/2012/04/DuchCon-Fig12.jpg) >> endobj 196 0 obj << /Type /Page /Parent 3 0 R /Contents 197 0 R >> endobj 197 0 obj << /Length 11473 >> stream q 15.000 73.333 577.500 703.667 re W n 0.965 0.965 0.965 rg 26.250 747.845 555.000 29.155 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 747.845 m 581.250 747.845 l 581.250 748.595 l 26.250 748.595 l f q 35.250 759.095 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 767.476 Td /F4 9.8 Tf [(Fig. 12: Most frequently used therapies reported by participants)] TJ ET Q BT 26.250 730.821 Td /F1 9.8 Tf [(Calcium Coenzyme Q10, and vitamin D are among the most common supplements used \(17%, 13%, 21%, respectively\); see )] TJ ET BT 26.250 718.917 Td /F1 9.8 Tf [(table 4.)] TJ ET q 450.000 0 0 189.000 26.250 520.036 cm /I28 Do Q BT 26.250 503.012 Td /F4 9.8 Tf [(Table 4. Use of supplements, vitamins, other medications reported by participants \(participants can choose more than )] TJ ET BT 26.250 491.107 Td /F4 9.8 Tf [(one\).)] TJ ET BT 26.250 454.505 Td /F4 12.0 Tf [(Summary)] TJ ET BT 26.250 434.550 Td /F1 9.8 Tf [(The DuchenneConnect registry holds data about DBMD of interest to academic researchers, clinical investigators, and industry. )] TJ ET BT 26.250 422.646 Td /F1 9.8 Tf [(This includes family history, genetic mutation status, ambulation, corticosteroid use, pulmonary and cardiac function, and )] TJ ET BT 26.250 410.741 Td /F1 9.8 Tf [(supplement use. De-identified data is made available to academic and industry partners to advance our understanding of )] TJ ET BT 26.250 398.836 Td /F1 9.8 Tf [(natural history and facilitate the drug development and clinical trial process. Participants in the registry benefit from educational )] TJ ET BT 26.250 386.931 Td /F1 9.8 Tf [(materials and targeted contacts about relevant clinical trials. Looking forward, a new report of selected registry data will be )] TJ ET BT 26.250 375.027 Td /F1 9.8 Tf [(available biannually through the registry website. Bivariate and multivariate analyses of clinical interest are in process and will )] TJ ET BT 26.250 363.122 Td /F1 9.8 Tf [(be reported in the near future.)] TJ ET BT 26.250 326.519 Td /F4 12.0 Tf [(Competing Interests)] TJ ET BT 26.250 306.565 Td /F1 9.8 Tf [(The authors have declared no competing interests.)] TJ ET BT 26.250 269.963 Td /F4 12.0 Tf [(Acknowledgements)] TJ ET BT 26.250 250.008 Td /F1 9.8 Tf [(The DuchenneConnect team extends its heartfelt gratitude to all the families who have provided information to the registry. )] TJ ET BT 26.250 238.104 Td /F1 9.8 Tf [(Sharing their knowledge and experience empowers families and enables them to directly impact research and advancements in )] TJ ET BT 26.250 226.199 Td /F1 9.8 Tf [(muscular dystrophy.)] TJ ET BT 26.250 197.096 Td /F4 12.0 Tf [(References)] TJ ET BT 26.250 169.642 Td /F1 9.8 Tf [(1.)] TJ ET BT 38.132 169.642 Td /F1 9.8 Tf [(Bushby K, Finkel F, Birnkrant DJ, Case LE, Clemens PR, Cripe L, Kaul A, Kinnett K, McDonald C, Pandya S, Poysky J, )] TJ ET BT 26.250 157.737 Td /F1 9.8 Tf [(Shapiro F, Tomezsko J, Constantin C, for the DMD Care Considerations Working Group. Diagnosis and management of )] TJ ET BT 26.250 145.833 Td /F1 9.8 Tf [(Duchenne muscular dystrophy, part 1: diagnosis, and pharmacological and psychosocial management. Lancet Neurology 2010; )] TJ ET BT 26.250 133.928 Td /F1 9.8 Tf [(9: 77-93.)] TJ ET BT 26.250 114.523 Td /F1 9.8 Tf [(2.)] TJ ET BT 38.132 114.523 Td /F1 9.8 Tf [(Bushby K, Finkel F, Birnkrant DJ, Case LE, Clemens PR, Cripe L, Kaul A, Kinnett K, McDonald C, Pandya S, Poysky J, )] TJ ET BT 26.250 102.618 Td /F1 9.8 Tf [(Shapiro F, Tomezsko J, Constantin C, for the DMD Care Considerations Working Group. Diagnosis and management of )] TJ ET BT 26.250 90.714 Td /F1 9.8 Tf [(Duchenne muscular dystrophy, part 2: implementation of multidisciplinary care. Lancet Neurology 2010; 9: 177-189.)] TJ ET Q q 15.000 73.333 577.500 703.667 re W n 0.965 0.965 0.965 rg 26.250 747.845 555.000 29.155 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 747.845 m 581.250 747.845 l 581.250 748.595 l 26.250 748.595 l f q 35.250 759.095 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 767.476 Td /F4 9.8 Tf [(Fig. 12: Most frequently used therapies reported by participants)] TJ ET Q BT 26.250 730.821 Td /F1 9.8 Tf [(Calcium Coenzyme Q10, and vitamin D are among the most common supplements used \(17%, 13%, 21%, respectively\); see )] TJ ET BT 26.250 718.917 Td /F1 9.8 Tf [(table 4.)] TJ ET q 450.000 0 0 189.000 26.250 520.036 cm /I28 Do Q BT 26.250 503.012 Td /F4 9.8 Tf [(Table 4. Use of supplements, vitamins, other medications reported by participants \(participants can choose more than )] TJ ET BT 26.250 491.107 Td /F4 9.8 Tf [(one\).)] TJ ET BT 26.250 454.505 Td /F4 12.0 Tf [(Summary)] TJ ET BT 26.250 434.550 Td /F1 9.8 Tf [(The DuchenneConnect registry holds data about DBMD of interest to academic researchers, clinical investigators, and industry. )] TJ ET BT 26.250 422.646 Td /F1 9.8 Tf [(This includes family history, genetic mutation status, ambulation, corticosteroid use, pulmonary and cardiac function, and )] TJ ET BT 26.250 410.741 Td /F1 9.8 Tf [(supplement use. De-identified data is made available to academic and industry partners to advance our understanding of )] TJ ET BT 26.250 398.836 Td /F1 9.8 Tf [(natural history and facilitate the drug development and clinical trial process. Participants in the registry benefit from educational )] TJ ET BT 26.250 386.931 Td /F1 9.8 Tf [(materials and targeted contacts about relevant clinical trials. Looking forward, a new report of selected registry data will be )] TJ ET BT 26.250 375.027 Td /F1 9.8 Tf [(available biannually through the registry website. Bivariate and multivariate analyses of clinical interest are in process and will )] TJ ET BT 26.250 363.122 Td /F1 9.8 Tf [(be reported in the near future.)] TJ ET BT 26.250 326.519 Td /F4 12.0 Tf [(Competing Interests)] TJ ET BT 26.250 306.565 Td /F1 9.8 Tf [(The authors have declared no competing interests.)] TJ ET BT 26.250 269.963 Td /F4 12.0 Tf [(Acknowledgements)] TJ ET BT 26.250 250.008 Td /F1 9.8 Tf [(The DuchenneConnect team extends its heartfelt gratitude to all the families who have provided information to the registry. )] TJ ET BT 26.250 238.104 Td /F1 9.8 Tf [(Sharing their knowledge and experience empowers families and enables them to directly impact research and advancements in )] TJ ET BT 26.250 226.199 Td /F1 9.8 Tf [(muscular dystrophy.)] TJ ET BT 26.250 197.096 Td /F4 12.0 Tf [(References)] TJ ET BT 26.250 169.642 Td /F1 9.8 Tf [(1.)] TJ ET BT 38.132 169.642 Td /F1 9.8 Tf [(Bushby K, Finkel F, Birnkrant DJ, Case LE, Clemens PR, Cripe L, Kaul A, Kinnett K, McDonald C, Pandya S, Poysky J, )] TJ ET BT 26.250 157.737 Td /F1 9.8 Tf [(Shapiro F, Tomezsko J, Constantin C, for the DMD Care Considerations Working Group. Diagnosis and management of )] TJ ET BT 26.250 145.833 Td /F1 9.8 Tf [(Duchenne muscular dystrophy, part 1: diagnosis, and pharmacological and psychosocial management. Lancet Neurology 2010; )] TJ ET BT 26.250 133.928 Td /F1 9.8 Tf [(9: 77-93.)] TJ ET BT 26.250 114.523 Td /F1 9.8 Tf [(2.)] TJ ET BT 38.132 114.523 Td /F1 9.8 Tf [(Bushby K, Finkel F, Birnkrant DJ, Case LE, Clemens PR, Cripe L, Kaul A, Kinnett K, McDonald C, Pandya S, Poysky J, )] TJ ET BT 26.250 102.618 Td /F1 9.8 Tf [(Shapiro F, Tomezsko J, Constantin C, for the DMD Care Considerations Working Group. Diagnosis and management of )] TJ ET BT 26.250 90.714 Td /F1 9.8 Tf [(Duchenne muscular dystrophy, part 2: implementation of multidisciplinary care. Lancet Neurology 2010; 9: 177-189.)] TJ ET Q q 15.000 73.333 577.500 703.667 re W n 0.965 0.965 0.965 rg 26.250 747.845 555.000 29.155 re f 0.267 0.267 0.267 rg 0.267 0.267 0.267 RG 26.250 747.845 m 581.250 747.845 l 581.250 748.595 l 26.250 748.595 l f q 35.250 759.095 537.000 17.905 re W n 0.271 0.267 0.267 rg BT 35.250 767.476 Td /F4 9.8 Tf [(Fig. 12: Most frequently used therapies reported by participants)] TJ ET Q BT 26.250 730.821 Td /F1 9.8 Tf [(Calcium Coenzyme Q10, and vitamin D are among the most common supplements used \(17%, 13%, 21%, respectively\); see )] TJ ET BT 26.250 718.917 Td /F1 9.8 Tf [(table 4.)] TJ ET q 450.000 0 0 189.000 26.250 520.036 cm /I28 Do Q BT 26.250 503.012 Td /F4 9.8 Tf [(Table 4. Use of supplements, vitamins, other medications reported by participants \(participants can choose more than )] TJ ET BT 26.250 491.107 Td /F4 9.8 Tf [(one\).)] TJ ET BT 26.250 454.505 Td /F4 12.0 Tf [(Summary)] TJ ET BT 26.250 434.550 Td /F1 9.8 Tf [(The DuchenneConnect registry holds data about DBMD of interest to academic researchers, clinical investigators, and industry. )] TJ ET BT 26.250 422.646 Td /F1 9.8 Tf [(This includes family history, genetic mutation status, ambulation, corticosteroid use, pulmonary and cardiac function, and )] TJ ET BT 26.250 410.741 Td /F1 9.8 Tf [(supplement use. De-identified data is made available to academic and industry partners to advance our understanding of )] TJ ET BT 26.250 398.836 Td /F1 9.8 Tf [(natural history and facilitate the drug development and clinical trial process. Participants in the registry benefit from educational )] TJ ET BT 26.250 386.931 Td /F1 9.8 Tf [(materials and targeted contacts about relevant clinical trials. Looking forward, a new report of selected registry data will be )] TJ ET BT 26.250 375.027 Td /F1 9.8 Tf [(available biannually through the registry website. Bivariate and multivariate analyses of clinical interest are in process and will )] TJ ET BT 26.250 363.122 Td /F1 9.8 Tf [(be reported in the near future.)] TJ ET BT 26.250 326.519 Td /F4 12.0 Tf [(Competing Interests)] TJ ET BT 26.250 306.565 Td /F1 9.8 Tf [(The authors have declared no competing interests.)] TJ ET BT 26.250 269.963 Td /F4 12.0 Tf [(Acknowledgements)] TJ ET BT 26.250 250.008 Td /F1 9.8 Tf [(The DuchenneConnect team extends its heartfelt gratitude to all the families who have provided information to the registry. )] TJ ET BT 26.250 238.104 Td /F1 9.8 Tf [(Sharing their knowledge and experience empowers families and enables them to directly impact research and advancements in )] TJ ET BT 26.250 226.199 Td /F1 9.8 Tf [(muscular dystrophy.)] TJ ET BT 26.250 197.096 Td /F4 12.0 Tf [(References)] TJ ET BT 26.250 169.642 Td /F1 9.8 Tf [(1.)] TJ ET BT 38.132 169.642 Td /F1 9.8 Tf [(Bushby K, Finkel F, Birnkrant DJ, Case LE, Clemens PR, Cripe L, Kaul A, Kinnett K, McDonald C, Pandya S, Poysky J, )] TJ ET BT 26.250 157.737 Td /F1 9.8 Tf [(Shapiro F, Tomezsko J, Constantin C, for the DMD Care Considerations Working Group. Diagnosis and management of )] TJ ET BT 26.250 145.833 Td /F1 9.8 Tf [(Duchenne muscular dystrophy, part 1: diagnosis, and pharmacological and psychosocial management. Lancet Neurology 2010; )] TJ ET BT 26.250 133.928 Td /F1 9.8 Tf [(9: 77-93.)] TJ ET BT 26.250 114.523 Td /F1 9.8 Tf [(2.)] TJ ET BT 38.132 114.523 Td /F1 9.8 Tf [(Bushby K, Finkel F, Birnkrant DJ, Case LE, Clemens PR, Cripe L, Kaul A, Kinnett K, McDonald C, Pandya S, Poysky J, )] TJ ET BT 26.250 102.618 Td /F1 9.8 Tf [(Shapiro F, Tomezsko J, Constantin C, for the DMD Care Considerations Working Group. Diagnosis and management of )] TJ ET BT 26.250 90.714 Td /F1 9.8 Tf [(Duchenne muscular dystrophy, part 2: implementation of multidisciplinary care. Lancet Neurology 2010; 9: 177-189.)] TJ ET Q q 0.000 0.000 0.000 rg BT 291.710 19.825 Td /F1 11.0 Tf [(8)] TJ ET BT 25.000 19.825 Td /F1 11.0 Tf [(PLOS Currents Muscular Dystrophy)] TJ ET Q endstream endobj 198 0 obj << /Type /XObject /Subtype /Image /Width 600 /Height 252 /ColorSpace /DeviceRGB /Filter /DCTDecode /BitsPerComponent 8 /Length 48954>> stream JFIF;CREATOR: gd-jpeg v1.0 (using IJG JPEG v62), quality = 90 C     C   X" }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?_=4K ZIs=RI+9@I8 &$8/P^*p(Ͻn0G?W?Dx{?>gޏp?<B?Q #+Uw4gޏp?<B?Q #+Uw>揪>_~3*Q^⫾{Gpȇ?Dx{?G?WzR@.iS_[?ˆ G(ЯgUH=:Rx\:vpCG?W?Dx{?w͂ph4[_[?G?W?Dx{?>g}W g #+U<B?W#7uG0ȃuˆ G(ЯgU0zA}n<G?W?Dx{?@ҍy(ЯgT<B?Wx9Ma0/?Dx{?*◠G0?vy(ЯgTˆ ^)_U"ˆ G(ЯgU1.iSu/?*G?WIz>D[?G?W?Dx{?@ϹuU"Q^*?Z7{}ngˆ K #+Uw3OA(ЯgTˆ ]}A(ЯgTˆ ]}ϽU"Dx{?G?WhϽU }ng #+U<B?W}zSL?À*Q^⫿9sIuǨ\6[?G?W?Dx{?wN)S?Dx{?G?WISG0/ #+U<B?W~r=#H#_U"À*| U\ޣTÿ5O!]6hn"xna*[*R2zvWkw ?`IsE|sSYX춤aԤ:~}b4NWR6m,R"}1*¿s_z8JW2>B 9\ʌ_Һ.߯<_BBR>S``¬ G*л~Kr?QWW .߯aB?̃;`]_*н~« G(2PE7n##8\UbOH%L/kúNgy> Y!4$xqk'w>#k6W~qklC v۴%ݲk(|+zoŽν =_gZMբX 88<+! xš[ȗx\F@$& @bzW Ȼ~c?jY%m[tH$NÖ j1rU'fʣNp>E3ZQ,-Cm ~Jؿ𯀯o3yaJgϷ͖湓ɪjDMac@:T?!|\gZڢ1  +T?{nvٕ|k<+h亵({Rm\q>@#X,5KkQ5x~_z <_oץӵYZxF)E?WU =_? <^1_^K0;`]_*л~« K4S`F« I eק]}Zc"+ <_B eףN)E?WW .߯aB?̅z`F« G*л~" N ltwG}^fr>>uaB /_߯X>S9L)1¬ H~÷o*zRzN*%𞍦|.ѓ)n/i]¡ EH󁞤dt'>[^е_[q=wW7WT_݈@nNOL~#>tҵOyb/]֫/]il>C Fn#^ )6^I~?^geht<Ί<’KmH//./u:HKy+p_1&{oN+-W˰ -Ay?/JԾxVCn%mL񌱮^SDth|\ͻeh2T *WZ7KHڤ-`o%TS0ryJqZ=S=Vz]E ͎Ln򭃃ۏ>L^ĺ\^ =1N\WVe[J׬M׃b7709dҷ4o^Iy߮M2Q{Ycb_Ky9'6><:{{xM4n8⯙ؓ'tdtx2gtdtxad)$?Γp=$K+zz=:}֩"Aؐ\9=؅Q8 ߅s?%/ ݎHu+Qą;AR*694 ez;./>]0n㶝zƣ%oڣeghr3?ßGL7L5.mnr&۽ez;MofeMwҦ:R2J *wN++ˡKB⍗pV>/>uXۼrFf|@zաrEn2Iu$5@ſ ]k7ZvCn|:1ܜrlkk~'6w/ٵ'" X'N]Ї_taKCcdNۀ$ʮ0,s+"o 5Ms,cE,Eo02\18Rk]K7,N;P҃hWG/'+,e;FJ=kĒq ݪG4XtKLnBqnc4j.t9Z[4Gaʶ8;V0_玵6a7B3s$HXP kG5#\_33|e>̷֚ͅ7(UXFEmܪ޲֞˯~ҭMr%j(¸??&/+,OwVW`-ͽGN<ЁU~&֭4_i֚6]ߝ,SZ1aFP\lsuu6)SC/4RLmެomk% &Yc(3A6g^'[jwVaI"\~z @C]m.<'L&vOsm zCjr;Lj,@մ; p#9 5G3wz>3&ҬXn.<ݾ1ZMSVO6֑kr5h{6p!g9+jxQӍ,M",Z$,%d'* x.5SSp:;m< \hXu=U .5v0;>IQ O5ᏉͷKѬE$7b{~*Tִׄ;y6&Nr{]Oᗊȝ}:JBz:?3w8hse+t8tVz|]^{8+k% ZV]x;IӼv|84NT]J.]I FeU+Rk.>`=x8|LTFm'OQ$ n۳AÞjγ}^/ *kn`ϜuX-@hDQ $13rMD8'JO=OHH_֗x?m{h ΆxH[Nӯ?ʕ{|[,|=uj]Y< w( aYJ9Y{8+(ݛ~ңxG[ O)++{{u u){mmds$5/XT47JV;a%~ARg713ӕW$zN>PvU=*4KY#{4ВlqӥtXݵoN;SsKo9"#y)=@+kSMᖽ=V&9 V!r?(-`U? *x6Ex5K2]$ ~^4KQxBj ijB-#om˖FzSBG?6+Fٶ?lO-T6@-=k㷇e(=_Co 9mEei8݅^3g%x%{ki; YYUn. \|X/84;g𝿇V !mq6+\=/÷Z^.ѥ-f#ŞxQ5pt;m-0ȅ@A"N5K#)|[#>W|n6{[P"xVUuZ0rW$՟4ܤF6ww{OerS4Uo-+FG[%d*683*Hv/:^}OM'җxr]J4 y.b#㲠台23oG]o'lu4[̅H`)8ݸmh񍧋gLnHHW.>A~>xV"ԕ?, O;_26ڲml2r!?Zo q?&G|W#C{EpZKqm̗zO/l2"d@+?^Yrt'JUs"rq'+ub]E?lO½?|z(=NS¼OZQ9{8+/5ye?uv'% {kK)eSދkYeSS{8ro5<ӿ^Y]D]O֥ǽH+/?5?_YǮ\H+/?1꾣k[kG/uMˌ+SSpcj𯬈5? jdRO]) 5!/=uO<}e?U5_j.97XffYĺ^;_59w)B'KOoGh2QR>a9CLgDw7%i-!}+ĒFW6*õq_xbóox;XZ:I7/6GJ|e9kν "Gj[K˧}ܡvhy;zt.c_B4$KP>~ EbI?gZKK(mbR@&/C8#j_i:Zz\/>KO\phpQl^k6^5{+·$"$L67z[> Ҭ짺RԢI$kT OZ?Ś/<3?+n/[7#M2L{޺k_?doZnb}"i..RDvV!m7 =z'o<%?Ñ4ys"告:`;Ȯ22 bMRHyhtDW5oo+Njl4OZVַlfH<"ZY۳+~xľkmS\>2Neꋦ0xeYH Ju Ͷ ~{M-.,%ExIp }s_KerIMr: @_Ti?3WIAwc?)ydS֮b;$NH|<S^˵]n) rHUnm=~f_~ʬD[@?a_گ(>\r,p5O z_Wv85LV<HwbTפ{dO^}i>Z|qZwn-7 f_q=ni+%?7jZ|>H+/=𯬏jgm.iw]~٩k>Y]^3@\\Ar,S֥ye?u𣝇¼OZW_kWW.(ar,S֣v'' u? jiye?5뮦SrDo|knyV3j>8[?h|>H+?1b?TǮis˸{8+/Ǥ?T׮m!Z|/gskX^[P!Mnա?kw֊9"r{k,T(.y¼S_i?5뭤H ~K1Hi<;+osH(i1EO? xΚ|7-NishK ӥO `.t]c:^5|3]\m6q.+ՙ-U>|@!;4O\h:N#ڋ9mY!_*DsZe}WQ+w9Ե}Kwg)'+}R^C;Ya?]bpm[lgd $\$P5{CYurTF0TO |? /φ-m,?ڑC ao2O ~>.h0ie_&j %joLg{q~^ע.?iHRDŜoMԮq^$޾O7ƺu ]xJ/ir]\A,< |T-I$cڋT^o4\,KT56jכƩ:m\ [Y~'VTծEyJ}O~~)Eu75촫fY!.N̻l3& .pN$ee<z>obCNDΗc3&Hjɝ>ob\ߍ~"hv5ifyXcrMt; yƍc:G/ xQY Y-#e;i6:r}(zxjF֢WPrȮrUN|̀9>$Ў j6Vk\2Ewymp #=+goSO4;~(I1Dam4Q|MFOBxbNvci m6#%S‹k|!xnX-jC#Ucϴ]rʥ #^|u{n3&91Osp=k ~,OExKIuK!"8*p۹a*>=:-mR:r)Fl弽VN H}xo5ԶD$+vbۂ޾nm< 1եB<}.ѽDٿs'=u8n\,IR47G} Ab@yR 3L֋4i?#W?Kmi?#WcxƚOaX!i3dm :;x:ƑxVRjk#JA&͙ kڗM H#[ [NwA:ʌ PA㩮}Y־&w7ctk$l @T77u`s@zDR T0Fi֠ĽO2t)'?ߓCj-g-I]wʎ  / 5w:C͍K@, 4^-9hN[+(뉙@ߒr858v/Ş/ܖ~Ѵ J÷:O%ܐ^0v FI ?(g߉7>|+x^Y:u-ֲOkğd(g_ rk:a3;[B*9^#o>0W{- [ N+eGUcgy/Ik^"CZjߢpO1y 9XoxpZ^ݽW᭜[2:Y~8IQ'|yoKPp<  kZx5|HeDJ#!XHp$;wfr=% ֢] D-@:{46hc>1.kRlm2Qmidfx?z77c7Z=~m9"䌀p{|| # |>ڕ0]A\ JY7}ګx06ׇ|Mh|T54=FhN%*"kmwP@0KMZtmo`GKix5XpGQI/?ZͦmHѿ#~U^sKPռ#/,e2Y.+d@5_߃OXm:60=ĎqVp=~ze-KZZ5*W \g>/[Ť:2]dƢ)$!AmSA?y=ɸc?i&,tna5V~:QpD$N0=519MeP [ƏЅJߎƋ-?&VuK__<#WwGm%̩gF RIWw~4gDCour8UI ]'ghkMMe)ipn!r}'|-:v _úKip.dW`Hݍ\wQj͍s*4ȇ;7O@H^^%0𿏵Ago - G,ljC&=hKFo9WS~<6?9WP#5mf/h j[h<^5}sWswJ;^ յ+gC4z:l流"YH8U I9?~:>"YCJ/54w2[Lc7ʄ$L\zQmϨ!;-.>_H5mmk߁_Sk>ѫǃZpy>׿,OOI(d6ӂ*[/+|?[Ԭ ӵ٢gfn)ٜZ%^sїZ֣g{O΢K>Xv&IOΏuhrOt}~x 1&Qyw$I-F=l>1@[LwR>+ ֱ*A$7[pZesғP]S[Q}hcc1i>Rܼb>|#|xX.5mJ 7q64V.$Ök.>9 x}gU+ޥƕ%ЂrD6?LJF\ZGvF}h?~c.5mz #kR=ߪm_֗(:O H/ #>VA[λ ^?GYyON[q݊~5J/֙\hwvr&EgʎI0RA'Y7.e`p ?ZSkxQ׷ҾsoV6ڬ4H9%W> F0kKC05u5 Z-WDhaYcE2 @@Ri{2}PumvZqŮz^qԩqq߷ZxY~/hwW:XiDlF8ߍ~/x+M/zM{}8tXYB X߅OiK]O҃7֛H'q5]v7iA<`WZ%xSⶇ6;oRVVIhE>p-8jITGu<5׋ul`P$9l`lusҗsM}?nȓmuCڑs??l|9?&]h~*^-[C%" 3n㟈~kZ"Vw#\3$+砥Zfؑ9ol£s@sӷS{ g֧?:SX[˨WoaЭ͇\vW,Td^ĺ|k@on\`I#8&(>{{'_?w?kE3W¼nms o}(`- 3ǧ'uhc9a/.0x N>_WײX^ګu.O1l>+կCjZa,L'`=T r0)% WmYkG}i-8۾ 9NOΡO^sӊ7U8ñ7q`յx%'<ԟ۾ kGڐoKPqWZ֛'BXx'񾑵xsh{ t?߱^#YVk^Cml|R9`vy f9C0$cGW4:oquN$dE|{K.XċK ñw9փJu|uyuGO ,mo-|Q$v2^;eH5dɭ\!jZaVmRpwIk d% dt?7^"^x@eޒڥr`!db+*ył˧[YoNJc 8҃s'ֵ"kMG鉫qoۀ Nqc>:k^-<3Y,.kۛ-/WM0,!s@Z˼[};Ӭ4;Slo[Yx4f,``0 7->ԉkhއ/Z=k^^Qe̿2xMඍ85mKzTΪ#|SEr_gY-^DDٗ I.~P@a _ZvT]/X~,|y.o3Zxa4{鮬ךHdhA&[+ ݀@E} $LQTKok1Bom~V _A }ۧgL=)5\+˹'??:wq Zn=Wx?QJN |N_ij7V%Z5lbt7W(w0Hon !@Xs|N7P Q(~xCþ8>]u-t ӚUF:P8>kPjKV7gGo200{/V?m3xz$Լ+ix6sGm1|(Izαkkש.t|l*BOqMTB]7pGg<>Akv}6# :C~3Uxx)_zO?k+t/y0ܑ;Aw&? 7^]~bXl],7ae%A$`fi_ÝVV{/X^wu%w ck.2MVv~ϱͯ|.y5Yu?3) 3hZftiF0鮊]س,I?Zh/sYxN+&Fdb uJw}-0/84  œ9Qb/d O>w'UGׁ4#InEa'eq yJYH#\~h]صXnl,w^Xrvb}3W|ODϝaEçx5 O<5S]hTk B<h5_Z5厌n"EDMv;A^;O{g=u>w'R6Mt we3OtePXReLҼYϦk:1 |F5cҏk.VZ.yBKb T/jDONQK۶3 ly9CyKW ƺP5ɬğeӤ2}H^cK/7ws3R7 Z~TlyYOWJO,z_y#2m݄x߾ѴmTj@_-Dl͌XmQںo|Q'_NnnVP`HSp$㕅uN"ӭği9$Cb|$csj}^˹gsKNҴ:mX}\|Өe/<]%ޝڛY^4v RGE?WmЅ5Y{+jo|X(M,:iryQ>b2p85g~ߏm!'ၷƗlm8 5ou!xkޡGQ`沾2|kAji7z(<ʋW"s:Rݜo*nWյX v <֌~յiW!Kiˢo=Mw7<cheλi:}KIqp@Sw\VRx. _ >GY\t]*=ڇٵ{F.-x 1zo> mgdmgmK.A3:+$}u0֋f#j6I2긎'!o;PT7M{/6;?Ӆ>hb\^@_3sJ=ٱEO6O7|+ӣc#4Wҏo.0 Z_7K4 ǝe'Wk?&p4{w=#³x|NG q6pBv:iگ5i>eFKr9928A]f"B񶟤M{>ʺК0rD9#p'? |~[j.+7˒[B@X㲾TQ'ؤ^0SQ[9O^>#,@㚯˪%Q4Z0ZaӤuMzhm 71ve2Bs< 5|AcŶg&(>Uv1R;"yxZ/l5ֻo%֥iL;\}T$d&t^<-?D {vmâ$p?i=[xqV`'.rI 8ڤ5jhŮ{6Q0P%ؒھG'a/i^~͠Ώtz\e=)xi|>Ff;F^π{s^ 7.<),[6Yl66v Qbgl½*nt_){o ] | O Ҽ&iĢr/$Yw \V}?S3A 8$ԣxo-GmmؾSu;Hϝ'mq5{o w ="2 +byfF6ui:pɦVʭa*HA[foJvݧW {~U? <-Swv-mfVcoɃTuOvh=>tz&d.b?AW_cVpZ3WZ~|u{ 3v^&Ty-'*YYYA mxl׼OmĶ&lFK@E Zs*߲>Oy\/<0&@ˁWG euk³}uqݨ7gGj>|J'mKPΩm2 85!H-V=!h7l$mbo ޠv͓R 41}~=6x/o rNܺ]63ϻOIkN*0.*$ Uu"Rt/^ўԞ3\];ׅ,-i:ԫ+v(Ue== sOԇS $fc}) ;v,q9kᝇsZ}\9)iva<,Sc *,4{a#ȰƱrπO7Vl͎Fɀ=1?#i*?_*ؾ{fNk*vjMM>o$?xmFS|W[G-wQ#pI}JEN/eݏ]?D}_4؋ .|9}=byQs[0.t5W&D?tɴWў`A&r3,t5+~_/пPᏈ>"j0e{iRq{o؟[YA |(J}KGGt}Z&9FpzZۼqMAq? rꎌ/$[K\4MUF X184KڵH21Nܣ+Ń{}7G#oT;)6\qkL* H?ޥ6?/3?W?+k7>e}եmPcHy; ̯k+^ǎ?KU5+;[ui;ZϟE"8 MwX4Egi`,kXqub,ISgz'% Iۦ7>OL^\r3Ɨ6z HU6Ђ:~C˱~̚xo̟nC@עׅu+4.`F0Zw'_wk1pjvLl/1H?$D>޺61gNrzUy1ޙ#z.)d Q쯥~ s*LM`čCRw{_*QSw/ּ ?KQG$FzieZO7?/G?_*h孰 W͌\_*X2T==4=0)\6hژK&mE"yϰb~ߨtUUO׬][;'"ۜg3GR=3OKHIJ#@Ishs}g=>/H,YR/O[-'0GZӉe&R$_0{cc;7įw !/MědfeFGp AXUүNH3-$A'y<AZOha ͨj)e_RK`*i[}5\ k,bf`};◲[\~V|v;[Mʷ! A 6X…B3$1Gz\|d^L2n88?57:_*jC79!/~W~HnnoLa+Pvf|:e xKPuil^P0Q3#\ދMKN$.E->T*C@[\?ƙK+[6]0fg?J6JqzO޺#m쏉|߇`.,o7Wx3| i:y#I{yܰ!Wqc4x_aD:Xkx)7 -s_%ѣf4 x#OƺxgV87'I[+ @/Xq:3'fm. ?" X ; Cw,C`U;:_xs¾-WRҴM>{&7 *տؾ$D'Ml?|D˞lcǧ{e=9{ c<-m9 nhhʓ܃}9B+.=oXtˍ'_{ 7y{H[?ח؏Y]m$9"dDicdJ0qj//% +ÜuqGοiv>L_%7ƻuew-OFn+hrE#C!<8rq g-#l[=\~sS-1ujqJMJRKK/ta|l1?i#ڌ{SC>6?nOsca=@nh=?ƒ#_ell0 _n/tsh_Dkt!ߗM]> ^4m1#'mKOmS\^m3LwLq)[&V'u}f/6; H|GJt_YI$'E{D0IO\??a:'GXcit#/ cޒ=#_2X،?LSx ^t{H5EӚzyμuϝtȭPR;Œ`k<-V-Fm&Ӥ=UKM0+#[}' +! qxW<_]gxrQ/f4;Y`IafɍAe'OVt`Ȳt`?ns0菟hokſOI\ǩ^3cNZ[`7TWo5]/I}{Nդumm&;#Ȏ'$K(bs_iK  ~7cR5n,9>ߕc嵏?9b{-KğE+a\]5nцl&yrJ80?xú.Mo5K&0XdG#(x~bc Ya;!҇Kr}9⯉C.Ο?4gfi6en >13XujKk?x\ӴӞ93ZΉ`޾}ně+2HO[Ba\nQԘ;IOtW~1ͤ 'MApU- ZtzhoVZLjg=ޡmtM܉y$`q h$gd2x"WAV?nxnFÃ:U {[#ZK) + iKw r1_E?aˢxAed29`wI,#3Dy, ųZ\x̶۷hʓ3|~!2/Bx%&61M8t~6@lF'~xoǨ\<5:Z}\@ I%@Qp:^|?Ǐ?,<%MK̴V.k-uKiUB6Ѱ5> VȱOmą;=w}\V<Y|Diqyĉ 0Lb6' Ź&cCP>c>h^!ecE8"ugM9_o),5[?|%mQaCp\WZ+\E;q >01wamcfH!Gyoj23ֈ1Ȭ}C;vhć‹ +KheR^@VW s:WQ߇0|+<]r #MFA,r$ @Gq]>|;v˩]DdE&߄D]Br!lV|י'x^ eO-ĬYw.Fg'څ ~u94لsZpTb2ջ uMkKn|Audt'cmr-#[߇΁=Y4[BћR?0;jXs.x7.)3aǢm޵nJ +a'|i^h% GNYhV cڹKRiXx,mW$G Ѻ4R8@<C׶$ZOv !b>Y7#7ׇci^ MBJdkoZr6ҹW5똯%q/2/Эwyv NJ~8 OKt_ Y-.扯Ҁk#_ƏKt_ YBatk:.?U,-e 5STF5躵Z,NcxUgG|Lix"_NӼI<Ɯ=Ͷ\оދ0GB>CP{ubG+ؕtQ1[!_񦿊6V'L֋0G(x^ZCWoY^;ۥ 1de2,95-mºviәt1$w1w p ]֑c7[բR{]fNХեḐ',Wu?qo{{\ :اȮǚ^[3%Ȥck7'o\t9~~'ִ!'5"i>^jWzSF X|mQ,AF-5mm4 0ܠ|_{ize.ggbt֏K|yfϽ9&Dg,ǾYƾ/=hװǤImΝx!1 \O[j[hz7߆7' +Nc \Ch$M1xt$;rU{|L2𮕭5Ɯ5 d[Ky+ xyKMi,ռ]xn^VYVdSѹ+7#ޝ-j9,tDM(}gcvf.hkJ>.ѿ-ei;K] q=^\8\RfW?>k_Ƌ>9]'|1{ڦojQ@eœO3#`]8oS9n?tKEԴ4]K|"Y nqqTy/ xŖ> ƺƏ{erK.'#T CQxXPZcp! FI)˰q9d4Z*UR1_K4_ YB+1s&O YY$*8W=GkY'v>lE#B@atrڗCmSNP yB3O$Sv@P79둎|L=MR6:ơ=@]w8@|)^AkKE㲳V;2d4@۰34+>&'kweݥKs]OL-.̏Sqo>.=@< .mKa@8 ?7Kxе+Ch^#V`PF Vl֛{Ko7Yc7[nf(]i5y?EI.qyGu$Y q7xC-$wծ-RQ̗ 1ގVֿj-n DеY"ƵilI.- (.A |I}hxjY]YKt#~wM^]K<+\iΉ}rao,(U ap^,Pܤk&Z$Iw VVbZ~? #˝^R+(~ݬZ9VU8FsfV3t^M}CM~=V]-!X(^-ŀت+6  o+KۿM2WñxDŽ%^>S[imY $19`֌?7O;եki̖os"fmH8 ~x_> et2Qmesf72G\)|y&W:imƉ,2rL$Ww׭u+lsWJܥ͔q%09=tZ "|I35GOGi?ö>Kh-l bJ!y P6l KT. w-]j=3kqUlJ3茜Ws]-}K]U_g*Lr9CMLm'I 2,FA:u_(|GPY=|Ũ̪c׊?o|Vӭ]7Hׯ>ӣZ[JJ8 Ls\h\+ϊ>h/4+=M^5E6 gMvg?ýgw,cz R܋{G|+G5JBvRho٢1(4_?I3J٢1) $`?RP[] ďmL 56}y>\ӏ(qq8=35Oˣ;J\a"Z]A3y2)>< gԠ#]Y2/+.VEGWxs׉4߉Vig.tri@"y3>c#WirX׵xo+[B3]H!T9UU,2ǜRrQH6D> D9)9$9[gxxs k,dh$@^ztR#Ҩk uk%JFv3+Ap|m~m[.L\(lp2Oq޺岏M6[S|5+En+H`;[+> 7QܶDMI.Xsj~Bnq]xt+Gɞ1 sWUNrNjSe4{}B1)\PFF3*mhV' }_jVݾM{=S5EwpZD&q=1}22=k?|u68_G:cAf\iw<2AA#E\|oGOu=$x'#{|qԛD)=z[X01 cߎ/)c䈉?FN9<+?? 6^Fim5SFS.:DNi׵O3*nzzCS~h z3?.WvMGX Co cGT>IforASq%{j$c4)9jҾ0x?[iqkwٴR(aIOKWrs6m<ݽ"cϯjM3zeAݝH㌩ޫjcy\>c(?ҝxFp U}%oN[V[Ev@{'jcvq;WCLG ⟅\u;goiK1KČF-j|9 m'uĶ//0vBkh?xfNx^=']ڥQm'u%M Z[rB!hqo4J#U# /?«P]i^L746`00 W:Q"]"|9)Lg?¦$Üq=㫰'" ڦXYM;F 'h/&q{8-!NE+Fd=<\ݠs[|%}jV,kn+mVA&8=/|Gx–Zn|mm:mPֆ?*6'u:jȫW;89mOW"ifbmZ903NR ~P@sᧁL?JUjh?|e3F@3q4{Iw|oZk'o1\ XmWPkpxp:- lH㸚&VKˆX)˾͟+2ʚܖNjyG],[y-)G#/qgRsA+i.(O _x«x&I??W}Y.?ܣK{(˱?s/>.vQi.T#+cn1xqo}>?vQ%8>?Ue͌ ).>SCX|A?i.Q9a;);\/:R/i.E_ w#cws!x»j(W$N#+ Cu૛KwaNNG܏jg%K:q}kK$ϼYTA.3!x»uE N!|8 jp=@*S+۸]FG<:qg<rNId?;c-oRKOJGҟ\cfpğ\1$ͼ_j?Wm)6'^'x/oܮs\x3H2E.yw8[OH.0ǼHۼ]F_'j?i.Q8+x.G…L[1WmE.yw+Gn@/\߈»jC֟r]( o!w =zU@O?s 鴏_گ'J=\/Mjq(۟vQ%~O 'c nF3~vRONP8٢HܒѾ@vQ'ܟguA+q{(G ?x— vQe=NWycnP}qxº}GZZ^]Dx =<+K=t8+ <_G W=R7j=Ӌ8+D;xSn ZuMWMlR8A.qw)?_G:WnV8i>T8x֦/ GcWmE |ks.FjRݣE(sH(QQVEo:F>yYZ5ϋxI~BzEuZvW: qg<ЃкA_kGூ'qjuJSyux41i^ Cž1x5f-k|dE7"H#;GqI#!\k]"~!?P>qϋP:q4H,ik8cVqētV=6}.㽒;OHNL@B9&'GVW/RҶp~{0nBr?kpNҹ##OV O7NV8KdUVppH\dT!į ρ䲸Ewԍ,w<14*:W4SZi{ڎu't"@JnSV\* 8tOxėզ _4wlE7m 灶|Mu _{JcM6ۥKb-> m^n<+ej֚݉XdApAZW 6g@|>cCo}xZD3=%RX8_pjwkO|Qtiu{iYgVf]lhffQ{G~gQKy?1V;uTsG_ '>d>g ؀n̗gdr0yj?ށYkk袒| d_sQME^7ZݝJ5r&s cFx> IjSԭ4 |<5X/-oh6"@ZӣeA*iytgqq yOmwEw{j7Zw"Xh7L!XDד5Z]6pX:kv4v&tC7Sٶ %Cd X1=)&4I?6k;J$]o@,ab{tHU2sFHdUK?hzW}Vs{! G 0pkUZ?粖{}h!Sr^c k_ e>`uhWQҞugfUWd,}h)+;KKMD$YϖrW=xqV:ZKs ww- +˴ArqҵGQǽ|B ?X\Ox(Y2#-8OZuą}6u-Rʏ/2^eqH56k"ӵ=;<#7{u$ A&Tp4':48C#]$Vw|KFִ4D1lzO|n> |D^m_QR ΍8hQ s򱐒E{ť]<ci=oQU#)s4dQ'hɠ sEGIhɠ zZ>|' 9Z I/o-K]ZEUJ~VZdž4 OF%)퓪61)@m!2@SE5[ʡ5pX)H냊^v6Kv1=Ae3)~fwW;V< 5@zpeAc?EyEsLju_?;|;`;E^Ŧ?F)84N*6zf;O"۽&D,nέp fIVQN((q ȱ f-4.iO"uG{8ܳ nLRk\'Ugt˞* kwp4Mi'(4rD/"%=;R]Ϧ*Rqiw,[Ϟ(]~ǧ?G{8ܲ|[Ϟ*P4cG#s)>H4[д'Afq-7o'U=CEKuӿE\'U9";˹gw|'G%O"qGrDW}k??.N_0=(],]Ϟ)-N[0(q KӿE4] sO"J=BIomrEbO'Rr]=;U~(ҎHrvfo'N]'?cA[8wg{}4m(]=;Un(Wqx\ O$'?%=;UlQG$Bct~Ŧz'Afl'U^.Ku.zw]$鿌[F#҇N#mCDc[7jɎNR[y?O-הlu^[.X܏P.Nź =8|Er7)\xFͷ}Fd7)fp28ɥi04h =dPH8sG,'#>/ɴӀk+/:Rk? @xVUUp~^E}ލJ) 4k @={iF1AsJ4.N]Ϟ*|q\i6nQr]yO"qGrD..Nz=4TQG$Bgw|m)?.N_Q>r9x{w^g_BRhsݘ1$U9{>N֬nRn\Hw9ں)%ІdUo5 .DYl.bóU·\q+nZGfK{q}U# n zUt Xv2HZ^wsjɵ^Mmk3H㑑: @+uIO:?,[6g-ab2If%usQ5/|5o,п4Th.P (8,<kb+XdInI#`yքG3رE-Q@(9u==7aZL ៌O{;M7\I{=,bpqygYΛkPY,{[]<4sG=(/DuR);zSsKG,AVEy Z\x%Chͤ3I#mHJčs[rً֊[rmm&nXpzRNutRg"韥 JȮD|R6՝W$ [wzַS:T5;'\qe OJwd$4Śnźq1q+t%1AirZfp듊xLIQhEf (RGdgx]sGos}!"A 0>Vt4]VHX.ݐ8Y&#M+w斛#=i (4R.è[ q_Lj:Ɵijjd,5t nZ}ݦ)\60\Bm,n0@nrq*)6h7S{K~ Htm&IWV,I''xAg,g-ƕaw\K4{rJ>`95_Y:fluKh":>T|Y/i'SƢYLo'](vx51TXek "Ӵm: YSB]ݸdI4`I# aioaojj ڕ)69$H͜dthpOr>0^t{{Ck\*7),L|9}ؾH^$HsW}դ%S;KE!FS 㿋Z?iyej7"M"Ů49q3U4RYӭ[;XCe`931|%0/j_8e-OT?#Y͟&DDj.\;n8~&(?Ox7P S:i|'KMֵyyqkO&yIgu3DFJ62>}Si߉S 6χ,=7&{>[qTk~_x[Dt~-tkFͩ^^%7Tqo׿5 >}C?K=72۝pNI^6"➅Z50[A(UiK1>^>׋ 3{%(.\~vO.','V];_-%7 P]F9'e_tt tHŞxd}bHOf^~j@,uJ?׏_.?"SWKKERԼ)ui{=[]xs,weϷ#*x^ٯp]W gZ ->o)1{ ]>&xJ?xJj7\ё^U&E7"P| MaȔ{_ }UF@)/?A5)/?]=Ww4rēq^Y.E3"R LaȔ} o?KRi{ws.YT+# {1V|]XiZDZau9oPWD `gx@?<]L%/ o;DJ \>:g]_S|_%kS|_%?jBsUu+IoXyhH8u5>ׁ)?׏vOڮƊky|7yHunޏ Yl' ׇv@&g6PA8>穃)X^UvI&x?<\DuS%M<>:]O?e6nSrϵp+.[ g^ͩ"ӯ%N]cP0T5 cJg;D]?<]"Ts:UŶg 8U& (cNjd;{ח MaȔkaȕt2OGWs^3f>#wZ?t{R`vޝ3 y2x@=3wi1ѦMPѱބu5Z_Y.Ϯl?M{?S<]%CCUwi|-HFdL/|^| pfxJ553%O: xg}kށg]ҧ׵3J J]Cegsl_A ߃~?DC힙s$7׿J^v#ziwWMaȔ MaȔ깣?5_kS|_%kS|_%/kr8y7<kkuH]hu;o2Ly\T?S<_%zJN} Pk'@o KGQpne!@'mvI&E7"Uf4s Ȥq^Y&E7"R LaȔo"j:_/6h-nU)=ku!'ohXlEٺck3bn Wn:]=~&xJ?O~vP/So/zO|(au7`v.A{@ޟ<]ǽ"Q.E3"U{U؟fo'8N7T>Y6O^k4&M/dy7@[˷F?,{XM)X endstream endobj xref 0 199 0000000000 65535 f 0000000008 00000 n 0000000073 00000 n 0000000119 00000 n 0000000724 00000 n 0000000761 00000 n 0000000951 00000 n 0000001194 00000 n 0000021106 00000 n 0000021213 00000 n 0000021321 00000 n 0000021432 00000 n 0000021545 00000 n 0000021665 00000 n 0000022053 00000 n 0000026410 00000 n 0000026537 00000 n 0000026657 00000 n 0000026784 00000 n 0000026917 00000 n 0000027043 00000 n 0000027144 00000 n 0000027272 00000 n 0000027371 00000 n 0000027499 00000 n 0000027597 00000 n 0000027725 00000 n 0000027795 00000 n 0000027923 00000 n 0000028007 00000 n 0000028135 00000 n 0000028217 00000 n 0000028344 00000 n 0000028464 00000 n 0000028591 00000 n 0000028724 00000 n 0000028850 00000 n 0000028951 00000 n 0000029079 00000 n 0000029178 00000 n 0000029306 00000 n 0000029404 00000 n 0000029532 00000 n 0000029602 00000 n 0000029730 00000 n 0000029814 00000 n 0000029942 00000 n 0000030024 00000 n 0000030151 00000 n 0000030271 00000 n 0000030398 00000 n 0000030531 00000 n 0000030657 00000 n 0000030758 00000 n 0000030886 00000 n 0000030985 00000 n 0000031113 00000 n 0000031211 00000 n 0000031339 00000 n 0000031409 00000 n 0000031537 00000 n 0000031621 00000 n 0000031749 00000 n 0000031831 00000 n 0000031929 00000 n 0000040277 00000 n 0000041303 00000 n 0000100225 00000 n 0000100352 00000 n 0000100462 00000 n 0000109909 00000 n 0000110935 00000 n 0000169857 00000 n 0000169984 00000 n 0000170094 00000 n 0000171120 00000 n 0000230042 00000 n 0000230169 00000 n 0000230279 00000 n 0000230398 00000 n 0000238402 00000 n 0000238529 00000 n 0000238639 00000 n 0000254312 00000 n 0000254439 00000 n 0000254549 00000 n 0000269216 00000 n 0000270002 00000 n 0000356156 00000 n 0000356283 00000 n 0000356393 00000 n 0000356520 00000 n 0000356630 00000 n 0000357416 00000 n 0000443570 00000 n 0000443697 00000 n 0000443807 00000 n 0000443934 00000 n 0000444044 00000 n 0000444830 00000 n 0000530984 00000 n 0000531111 00000 n 0000544475 00000 n 0000544604 00000 n 0000544715 00000 n 0000564918 00000 n 0000565047 00000 n 0000565158 00000 n 0000577838 00000 n 0000577967 00000 n 0000578078 00000 n 0000578207 00000 n 0000578318 00000 n 0000578447 00000 n 0000578558 00000 n 0000578687 00000 n 0000578798 00000 n 0000578973 00000 n 0000600615 00000 n 0000600744 00000 n 0000600855 00000 n 0000611293 00000 n 0000611422 00000 n 0000611533 00000 n 0000624833 00000 n 0000624963 00000 n 0000625000 00000 n 0000625129 00000 n 0000625240 00000 n 0000640009 00000 n 0000640138 00000 n 0000640249 00000 n 0000640378 00000 n 0000640489 00000 n 0000640619 00000 n 0000640656 00000 n 0000640785 00000 n 0000640896 00000 n 0000641025 00000 n 0000641136 00000 n 0000641265 00000 n 0000641376 00000 n 0000641506 00000 n 0000641543 00000 n 0000641672 00000 n 0000641783 00000 n 0000641934 00000 n 0000657833 00000 n 0000657962 00000 n 0000658073 00000 n 0000671989 00000 n 0000672119 00000 n 0000672190 00000 n 0000702567 00000 n 0000702695 00000 n 0000702732 00000 n 0000702861 00000 n 0000702972 00000 n 0000703102 00000 n 0000703173 00000 n 0000703301 00000 n 0000703338 00000 n 0000703467 00000 n 0000703578 00000 n 0000703708 00000 n 0000703779 00000 n 0000703907 00000 n 0000703944 00000 n 0000704119 00000 n 0000717162 00000 n 0000717291 00000 n 0000717403 00000 n 0000727282 00000 n 0000727412 00000 n 0000727449 00000 n 0000727578 00000 n 0000727690 00000 n 0000743597 00000 n 0000743725 00000 n 0000743837 00000 n 0000753317 00000 n 0000753446 00000 n 0000753558 00000 n 0000753688 00000 n 0000753725 00000 n 0000753854 00000 n 0000753966 00000 n 0000754094 00000 n 0000754206 00000 n 0000754335 00000 n 0000754447 00000 n 0000754577 00000 n 0000754614 00000 n 0000754743 00000 n 0000754855 00000 n 0000754983 00000 n 0000755095 00000 n 0000755162 00000 n 0000766690 00000 n trailer << /Size 199 /Root 1 0 R /Info 5 0 R >> startxref 815814 %%EOF