Comments on: Modeling the Impact of Interventions on an Epidemic of Ebola in Sierra Leone and Liberia Sat, 27 Oct 2018 04:18:43 +0000 hourly 1 By: Christian L. Althaus Wed, 12 Nov 2014 11:53:57 +0000 Thanks for clarifying some of our concerns in this update of the manuscript. However, I still think that there are some inconsistencies in your model.

After consulting the study by Legrand et al. and your paper again, I agree that the weighting of the transition rates is consistent and correct. The difference is that the study by Legrand defines a case fatality ratio delta that is then used to compute the scaling factors delta_1 and delta_2. In your manuscript, you call delta_1 and delta_2 case fatality rate and this might not be correct. From the ordinary differential equations, one can directly calculate the case fatality rate for the hospitalized as gamma_DH*delta_2/(gamma_DH*delta_2 + gamma_IH*(1-delta_2)). For the parameters from Sierra Leone, that would be 88% and not 75%.

If you model your system as shown in Figure 2 of the Appendix, delta_2 indeed corresponds to the case fatality rate in hospitals. In this case, you should change your ordinary differential equations to match the model scheme in Figure 2 of the Appendix.

By: PLOS Currents Thu, 06 Nov 2014 22:14:47 +0000 The authors updated this article in response to readers comments on the previous edition. The changes made are:
– Changed one symbol (iota) to theta_1 in order to be more consistent with Legrand et al and slightly changed the wording of this parameter’s meaning.
– Corrected a typo in the compartmental flow diagram.
– Added the appendix, which is a technical note on the model equations addressing some comments from readers of the article.